GO:0042421

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Name norepinephrine biosynthetic process
Categary Process
Go Slim No
Go Link GO:0042421
Unique Molecular Interactions 178
Total Molecular Interactions 263
Total Single Events 4539
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for norepinephrine biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for norepinephrine biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
2 INT63939 Vta1 Positive_regulation of Th 1 0.14 0 1.61
3 INT40887 Penk Regulation of Th 1 0.04 0 1.53
4 INT106070 Positive_regulation of Oprl1 Positive_regulation of TH 1 0.13 0.15 1.36
5 INT60989 Ngf Regulation of Th 1 0.17 0 1.34
6 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
7 INT98832 Th Regulation of Dbh 1 0.32 0.53 1.2
8 INT90644 Slc6a3 Positive_regulation of Th 1 0.51 0 1.2
9 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17
10 INT141246 Trib3 Regulation of Gene_expression of Th 1 0.02 0.17 1.17
11 INT60990 Bdnf Negative_regulation of Th 1 0.15 0 1.17
12 INT106069 TH Positive_regulation of Th 1 0.07 0.16 1.14
13 INT88446 Uncx Positive_regulation of Th 1 0.13 0 1.1
14 INT44838 Pitpnm1 Negative_regulation of Th 1 0.02 0 1.09
15 INT31549 Binding of Dbh and Vip 1 0.32 0 1.08
16 INT31547 Binding of Th and Vip 1 0.31 0 1.08
17 INT221 Chd7 Negative_regulation of Th 1 0.02 0 1.04
18 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
19 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 1 0.35 0 1.04
20 INT31548 Binding of Th and Dbh 1 0.35 0 0.98
21 INT133071 STAT6 Positive_regulation of Gene_expression of GATA3 1 0.55 0 0.95
22 INT184916 Binding of da and Th 1 0.09 1.22 0.87
23 INT122687 Binding of Galr2 and Th 1 0.13 0.07 0.83
24 INT122688 Binding of Galr1 and Th 1 0.14 0.07 0.83
25 INT122686 Binding of Galr3 and Th 1 0.14 0.07 0.83
26 INT63940 Negative_regulation of Vta1 Positive_regulation of Th 1 0.13 0 0.81
27 INT245350 Abat Regulation of Dbh 1 0.00 0.37 0.8
28 INT184918 da Positive_regulation of Negative_regulation of Th 1 0.14 0.14 0.77
29 INT147278 Negative_regulation of Calca Positive_regulation of Th 1 0.41 0.76 0.74
30 INT147277 Calca Positive_regulation of Th 1 0.48 0.76 0.74
31 INT144367 Gdnf Negative_regulation of Positive_regulation of Th 1 0.11 0.77 0.7
32 INT28975 Ins1 Positive_regulation of Positive_regulation of Dbh 1 0.21 0 0.66
33 INT313435 Syp Regulation of Th 1 0.43 1.6 0.64
34 INT7958 LOC686180 Positive_regulation of Gene_expression of Th 1 0.02 0 0.64
35 INT228852 Th Positive_regulation of Vta1 1 0.04 0 0.53
36 INT139750 Ubqln1 Regulation of Dbh 1 0.00 0 0.52
37 INT228851 Th Positive_regulation of Mtf2 1 0.02 0 0.52
38 INT184922 Negative_regulation of Th Negative_regulation of da 1 0.12 0.18 0.52
39 INT139751 Dbh Regulation of Localization of Prl 1 0.02 0 0.52
40 INT168110 Binding of Cnr1 and Dbh 1 0.04 0.64 0.47
41 INT168111 Dbh Positive_regulation of Cnr1 1 0.05 0.64 0.47
42 INT7957 Calca Positive_regulation of Gene_expression of Th 1 0.39 0 0.47
43 INT249021 Gabrg1 Negative_regulation of Th 1 0.08 0.06 0.44
44 INT157451 Binding of Slc6a3 and Dbh 1 0.04 0.48 0.44
45 INT121837 Sct Positive_regulation of Th 1 0.23 0.06 0.43
46 INT139487 Oprm1 Positive_regulation of Th 1 0.26 0.1 0.42
47 INT147280 Binding of Pecam1 and Th 1 0.29 0.41 0.41
48 INT302871 Negative_regulation of Adora2a Positive_regulation of Phosphorylation of Th 1 0.26 0.12 0.4
49 INT7625 Man2a2 Regulation of Th 1 0.01 0.07 0.4
50 INT34856 Hpd Negative_regulation of Dbh 1 0.00 0 0.39
51 INT31794 Hps6 Positive_regulation of Th 1 0.03 0 0.38
52 INT258762 Binding of Dbh and ADHD1 1 0.08 1.61 0.34
53 INT173476 Th Regulation of Gene_expression of Bcar1 1 0.10 0 0.34
54 INT34855 Negative_regulation of Maoa Negative_regulation of Th 1 0.17 0 0.34
55 INT173478 Th Regulation of Localization of Ins1 1 0.13 0 0.34
56 INT153019 nct Positive_regulation of Transcription of Th 1 0.19 0.61 0.32
57 INT153020 nct Positive_regulation of Gene_expression of Th 1 0.19 0.61 0.32
58 INT290614 Binding of Th and RLS 1 0.21 3.26 0.31
59 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3
60 INT90643 Negative_regulation of Slc6a3 Positive_regulation of Th 1 0.47 0 0.3
61 INT55404 Binding of ENG and Th 1 0.02 0 0.3
62 INT314484 TH Positive_regulation of RLS 1 0.01 1.66 0.29
63 INT42354 Dbh Regulation of Localization of Gh1 1 0.07 0 0.28
64 INT78484 Binding of DBH and TH 1 0.09 0 0.28
65 INT317773 Positive_regulation of GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
66 INT317775 GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
67 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25
68 INT329432 Binding of CCR6 and TH 1 0.00 0.47 0.23
69 INT329431 Binding of CCL20 and TH 1 0.00 0.47 0.23
70 INT61987 Th Regulation of Penk 1 0.46 0 0.2
71 INT281477 Binding of Pten and Th 1 0.28 0.4 0.19
72 INT349504 Ptpn2 Negative_regulation of Th 1 0.23 2 0.19
73 INT313453 Siglec1 Regulation of Th 1 0.02 0.61 0.17
74 INT317322 Snca Regulation of Positive_regulation of Th 1 0.01 0.23 0.17
75 INT88450 Uncx Regulation of Gene_expression of Th 1 0.06 0 0.17
76 INT349503 Ptpn2 Negative_regulation of Gene_expression of Th 1 0.23 0.7 0.16
77 INT194829 Gata3 Positive_regulation of IL13 1 0.01 0.12 0.15
78 INT194835 Gata3 Positive_regulation of IL5 1 0.01 0.12 0.15
79 INT194833 Binding of IL5 and Gata3 1 0.01 0.12 0.15
80 INT194827 Binding of IL13 and Gata3 1 0.01 0.12 0.15
81 INT194360 SNRPD1 Negative_regulation of Dbh 1 0.00 0 0.14
82 INT261456 Sftpd Positive_regulation of Gene_expression of Th 1 0.10 0.77 0.13
83 INT313441 Th Regulation of Siglec1 1 0.02 0.22 0.13
84 INT338428 Il4 Positive_regulation of Gata3 1 0.06 0.75 0.13
85 INT313439 Syp Negative_regulation of Th 1 0.30 0.14 0.13
86 INT197317 Nr4a2 Regulation of Gene_expression of Th 1 0.03 0.07 0.12
87 INT313454 Negative_regulation of Syp Negative_regulation of Th 1 0.30 0.14 0.1
88 INT313442 Th Regulation of Phosphorylation of Syp 1 0.32 0 0.08
89 INT313459 Gene_expression of Syp Negative_regulation of Th 1 0.30 0.49 0.08
90 INT313437 Th Regulation of Phosphorylation of Siglec1 1 0.04 0 0.08
91 INT125208 Pou4f1 Negative_regulation of Gene_expression of Th 1 0.28 0.67 0.07
92 INT125209 Pou4f1 Positive_regulation of Gene_expression of Th 1 0.33 0.67 0.07
93 INT313450 Th Regulation of Syp 1 0.32 0.6 0.06
94 INT242618 Binding of Slc18a3 and Th 1 0.13 0.26 0.05
95 INT193454 Dbh Negative_regulation of Negative_regulation of Ndufaf1 1 0.02 1.22 0.05
96 INT235640 Binding of GATA3 and Mrgpre 1 0.01 0.8 0.04
97 INT313433 53T Regulation of Th 1 0.00 0 0.03
98 INT313448 Gene_expression of Syp Positive_regulation of Th 1 0.28 0 0.03
99 INT313468 Negative_regulation of Syp Regulation of Th 1 0.30 0.3 0.03
100 INT313443 Syp Positive_regulation of Binding of Th 1 0.35 0.31 0
101 INT292968 Fto Regulation of Gene_expression of Th 1 0.30 1.11 0
102 INT313461 Gopc Regulation of Th 1 0.07 0 0
103 INT292970 Fto Regulation of Th 1 0.18 0.48 0
104 INT127058 Vta1 Negative_regulation of Positive_regulation of Th 1 0.33 0 0
105 INT313457 Ppp2ca Regulation of Th 1 0.36 0 0
106 INT49943 Binding of Th and Pdx1 1 0.02 0.17 0
107 INT163744 Binding of Th and Gfra4 1 0.09 0 0
108 INT313438 Mapk1 Regulation of Th 1 0.06 0 0
109 INT313428 Binding of Syp and Th 1 0.25 0.31 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for norepinephrine biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in norepinephrine biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4740 Gene_expression of Th 298 0.78 61.27 154.03
2 INT218 Positive_regulation of Th 245 0.70 40.5 120.1
3 INT7327 Regulation of Th 164 0.62 29.67 110.14
4 INT217 Negative_regulation of Th 134 0.59 26.83 62.63
5 INT350 Localization of Th 79 0.80 10.26 41.17
6 INT30817 Gene_expression of Th 142 0.76 33.56 38.12
7 INT7326 Transcription of Th 83 0.72 13.5 35.33
8 INT6558 Positive_regulation of Gene_expression of Th 56 0.70 9.64 30.89
9 INT7956 Regulation of Gene_expression of Th 44 0.61 8.26 29.31
10 INT1166 Negative_regulation of Dbh 56 0.59 12.54 28.26
11 INT4781 Gene_expression of TH 68 0.73 26.92 24.01
12 INT26719 Negative_regulation of Gene_expression of Th 38 0.58 11.87 22.78
13 INT3382 Positive_regulation of Dbh 33 0.70 11.64 21.67
14 INT13643 Phosphorylation of Th 20 0.82 1.9 20.97
15 INT24240 Positive_regulation of Th 60 0.70 9.92 20.18
16 INT14436 Gene_expression of Dbh 42 0.72 9.9 19.85
17 INT2960 Regulation of Dbh 32 0.47 10.32 18.94
18 INT219 Negative_regulation of Th 55 0.59 20.88 17.09
19 INT4073 Localization of Dbh 28 0.81 6.06 16.37
20 INT24241 Phosphorylation of Th 35 0.81 8.69 16.06
21 INT13716 Positive_regulation of TH 33 0.68 19.11 16
22 INT109264 Positive_regulation of Transcription of Th 17 0.50 4.73 14.33
23 INT31368 Positive_regulation of Positive_regulation of Th 19 0.51 2.2 12.68
24 INT141 Binding of Th 21 0.48 3.53 11.04
25 INT78567 Positive_regulation of Gene_expression of Th 25 0.68 5.32 10.75
26 INT48496 Regulation of Transcription of Th 16 0.54 2.29 10.02
27 INT109265 Transcription of Th 18 0.68 4.5 8.21
28 INT5401 Gene_expression of DBH 17 0.78 1.92 8.01
29 INT47546 Binding of Dbh 11 0.44 5.69 7.84
30 INT26643 Negative_regulation of Positive_regulation of Th 12 0.59 1.26 7.74
31 INT7624 Positive_regulation of Regulation of Th 7 0.50 2.41 7
32 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88
33 INT109266 Negative_regulation of Transcription of Th 9 0.42 2.5 6.85
34 INT66987 Regulation of Th 23 0.61 7.86 6.8
35 INT3506 Localization of TH 12 0.81 0.78 6.66
36 INT7569 Positive_regulation of Transcription of Th 19 0.70 2.6 6.17
37 INT133638 Gene_expression of Dbh 9 0.78 1.23 5.46
38 INT30317 Regulation of TH 14 0.43 7.27 5.38
39 INT7623 Regulation of Regulation of Th 11 0.44 1.31 5.16
40 INT24236 Positive_regulation of Phosphorylation of Th 12 0.61 3.68 4.87
41 INT37151 Localization of Th 13 0.57 3.11 4.82
42 INT40620 Regulation of Positive_regulation of Th 9 0.45 2.45 4.69
43 INT30165 Positive_regulation of Phosphorylation of Th 8 0.56 0.75 4.22
44 INT116011 Positive_regulation of Gata3 5 0.31 3.17 4.21
45 INT202417 Gene_expression of Gata3 16 0.61 7.84 4.12
46 INT77823 Negative_regulation of Negative_regulation of Th 9 0.59 1.56 3.79
47 INT5400 Positive_regulation of DBH 6 0.70 2.02 3.38
48 INT30166 Regulation of Phosphorylation of Th 4 0.50 0.52 3.33
49 INT102901 Regulation of Gene_expression of Th 12 0.60 2.42 3.22
50 INT15253 Binding of DBH 7 0.36 3.21 3.17
51 INT46291 Negative_regulation of Dbh 6 0.56 0.91 3.06
52 INT4782 Positive_regulation of Gene_expression of TH 12 0.47 7.36 2.95
53 INT133080 Gene_expression of GATA3 15 0.61 5.64 2.89
54 INT28376 Regulation of Localization of Dbh 1 0.31 0 2.87
55 INT2958 Transcription of Dbh 4 0.71 2.57 2.64
56 INT202419 Positive_regulation of Gene_expression of Gata3 6 0.52 5.47 2.6
57 INT106066 Negative_regulation of Positive_regulation of TH 1 0.18 0.22 2.6
58 INT106068 Positive_regulation of Positive_regulation of TH 1 0.21 0.22 2.59
59 INT4704 Positive_regulation of Negative_regulation of Th 4 0.50 0.06 2.56
60 INT13644 Negative_regulation of Phosphorylation of Th 2 0.43 0.06 2.51
61 INT2695 Regulation of DBH 5 0.45 1.09 2.48
62 INT184914 Negative_regulation of Gene_expression of Th 15 0.43 9.17 2.46
63 INT28971 Positive_regulation of Gene_expression of Dbh 4 0.47 0.58 2.39
64 INT15210 Negative_regulation of Transcription of Th 9 0.59 0.47 2.37
65 INT15209 Negative_regulation of Regulation of Th 6 0.51 1.64 2.16
66 INT2961 Regulation of Regulation of Dbh 3 0.24 0.95 2.05
67 INT1834 Positive_regulation of Binding of Th 1 0.46 0 1.91
68 INT314510 Protein_catabolism of TH 1 0.10 3.28 1.86
69 INT22087 Negative_regulation of DBH 3 0.59 1.45 1.84
70 INT3505 Binding of TH 5 0.39 2.6 1.8
71 INT145545 Transcription of TH 3 0.67 1.48 1.64
72 INT4074 Negative_regulation of Localization of Dbh 4 0.59 0.61 1.48
73 INT116014 Transcription of Gata3 4 0.63 2.24 1.46
74 INT133637 Negative_regulation of Gene_expression of Dbh 2 0.43 0.25 1.46
75 INT116015 Regulation of Gata3 3 0.22 1.41 1.42
76 INT116008 Binding of Gata3 2 0.34 1.37 1.41
77 INT141233 Negative_regulation of Positive_regulation of Dbh 2 0.42 0.39 1.33
78 INT116016 Positive_regulation of Positive_regulation of Gata3 2 0.21 0.5 1.28
79 INT97869 Negative_regulation of Positive_regulation of Th 3 0.25 0.79 1.23
80 INT38650 Positive_regulation of Negative_regulation of Dbh 3 0.50 0 1.16
81 INT26760 Negative_regulation of Localization of Th 2 0.40 0.09 1.14
82 INT50267 Negative_regulation of Negative_regulation of Th 3 0.42 1.57 1.12
83 INT89670 Negative_regulation of Binding of Th 2 0.43 0.28 1.12
84 INT133079 Positive_regulation of Gene_expression of GATA3 3 0.50 1.03 1.11
85 INT23716 Localization of DBH 1 0.29 0.06 1.11
86 INT28972 Regulation of Gene_expression of Dbh 2 0.42 0.86 1.08
87 INT50812 Regulation of Positive_regulation of Dbh 2 0.45 1.04 1
88 INT208792 Negative_regulation of Gene_expression of TH 6 0.35 1.11 0.94
89 INT198953 Regulation of Regulation of Th 1 0.01 0.1 0.93
90 INT30598 Negative_regulation of Transcription of Dbh 1 0.42 0.35 0.91
91 INT24242 Negative_regulation of Phosphorylation of Th 3 0.38 1.44 0.9
92 INT208789 Negative_regulation of Localization of TH 2 0.25 0 0.89
93 INT50266 Regulation of Negative_regulation of Th 1 0.42 0.94 0.88
94 INT53309 Regulation of Localization of Th 1 0.39 0 0.84
95 INT28974 Negative_regulation of Negative_regulation of Dbh 1 0.40 0 0.78
96 INT133639 Positive_regulation of Gene_expression of Dbh 1 0.50 0 0.75
97 INT2959 Regulation of Transcription of Dbh 2 0.45 1.18 0.73
98 INT116012 Regulation of Positive_regulation of Gata3 1 0.20 0.07 0.71
99 INT116006 Positive_regulation of Transcription of Gata3 1 0.21 0.07 0.7
100 INT116010 Positive_regulation of Binding of Gata3 1 0.31 0.07 0.7
101 INT4072 Positive_regulation of Positive_regulation of Dbh 3 0.50 1.77 0.67
102 INT202416 Negative_regulation of Gata3 2 0.32 1.17 0.64
103 INT17840 Negative_regulation of GATA3 3 0.41 1.96 0.63
104 INT122934 Negative_regulation of Regulation of TH 1 0.03 0.56 0.63
105 INT205470 Positive_regulation of GATA3 4 0.33 2.53 0.61
106 INT290660 Negative_regulation of Gene_expression of Gata3 1 0.25 1.52 0.6
107 INT13929 Protein_catabolism of Th 3 1.00 0 0.58
108 INT226481 Negative_regulation of Gene_expression of GATA3 1 0.06 1.41 0.57
109 INT314505 Positive_regulation of Protein_catabolism of TH 1 0.05 1.07 0.56
110 INT314499 Negative_regulation of Protein_catabolism of TH 1 0.04 1.06 0.54
111 INT144053 Transcription of GATA3 1 0.67 0.89 0.54
112 INT3381 Positive_regulation of Regulation of Dbh 2 0.44 0.37 0.47
113 INT299799 Negative_regulation of Negative_regulation of GATA3 1 0.09 1.32 0.47
114 INT134393 Regulation of Dbh 1 0.44 0.44 0.46
115 INT111304 Regulation of Gene_expression of TH 2 0.17 0.57 0.44
116 INT133179 Transcription of DBH 1 0.70 0.23 0.44
117 INT90640 Positive_regulation of Negative_regulation of Th 2 0.40 0.58 0.39
118 INT47547 Positive_regulation of Binding of Dbh 1 0.47 0 0.39
119 INT314511 Positive_regulation of Binding of TH 1 0.04 0.68 0.38
120 INT349488 Positive_regulation of Localization of Th 1 0.30 0.96 0.34
121 INT277462 Regulation of Positive_regulation of Th 2 0.09 0.23 0.31
122 INT40588 Regulation of Negative_regulation of Th 1 0.16 0.26 0.26
123 INT343976 Negative_regulation of Negative_regulation of TH 1 0.23 0.19 0.23
124 INT237448 Negative_regulation of Binding of TH 1 0.30 0.29 0.22
125 INT13931 Protein_catabolism of Dbh 1 0.58 0 0.2
126 INT140716 Negative_regulation of Protein_catabolism of Th 1 0.59 0 0.19
127 INT140717 Positive_regulation of Protein_catabolism of Th 1 0.47 0 0.19
128 INT111306 Negative_regulation of Gene_expression of Dbh 1 0.25 0.45 0.17
129 INT66986 Binding of Th 6 0.45 1.43 0.16
130 INT194746 Phosphorylation of Gata3 1 0.10 0.08 0.12
131 INT313420 Positive_regulation of Positive_regulation of Th 1 0.33 0.35 0.12
132 INT314508 Regulation of Positive_regulation of TH 1 0.04 0.92 0.08
133 INT313408 Regulation of Phosphorylation of Th 1 0.40 0.74 0.07
134 INT197017 Binding of GATA3 2 0.36 0.94 0.04
135 INT235637 Localization of GATA3 1 0.73 0.55 0
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