GO:0042427

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Name serotonin biosynthetic process
Categary Process
Go Slim No
Go Link GO:0042427
Unique Molecular Interactions 39
Total Molecular Interactions 42
Total Single Events 490
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for serotonin biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for serotonin biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT60827 Ddc Positive_regulation of Localization of Abat 1 0.12 0.34 0.94
2 INT60828 Ddc Positive_regulation of Abat 1 0.13 0.34 0.93
3 INT272039 Ddc Positive_regulation of Gene_expression of Aanat 1 0.00 0.26 0.87
4 INT189303 Atp6v1e1 Positive_regulation of Gene_expression of TPH1 1 0.01 0.16 0.73
5 INT99937 Ddc Regulation of Transcription of Qrfp 1 0.02 0 0.69
6 INT326586 SLC18A2 Negative_regulation of DDC 1 0.28 0.91 0.66
7 INT50634 Ddc Regulation of Gene_expression of Glul 1 0.02 0 0.65
8 INT127057 Ddc Positive_regulation of Gene_expression of Slc1a2 1 0.01 0.06 0.63
9 INT113146 Ddc Positive_regulation of Gene_expression of Nr4a1 1 0.06 0.1 0.63
10 INT127056 Ddc Positive_regulation of Transcription of Drd3 1 0.10 0.06 0.63
11 INT160156 Tph2 Regulation of Htr1a 1 0.30 0.75 0.56
12 INT281124 Tcf21 Positive_regulation of Binding of Ddc 1 0.04 1.21 0.54
13 INT56733 Ddc Positive_regulation of Localization of GLUL 1 0.00 0 0.54
14 INT93740 Ddc Positive_regulation of Tnf 1 0.00 1.45 0.5
15 INT64639 Slc1a1 Positive_regulation of Ddc 1 0.30 0.3 0.38
16 INT50635 Ddc Regulation of Gene_expression of Penk 1 0.03 0 0.38
17 INT281155 Binding of ITIH4 and Ddc 1 0.09 1.27 0.37
18 INT352821 Tph2 Regulation of Tst 1 0.31 0.46 0.36
19 INT326587 GYPA Regulation of DDC 1 0.08 0.83 0.33
20 INT126097 Ddc Positive_regulation of Egr1 1 0.08 0 0.32
21 INT1757 DDC Regulation of Localization of GH1 1 0.01 0 0.31
22 INT353979 Ddc Positive_regulation of Pet1 1 0.49 0 0.26
23 INT325767 Negative_regulation of Omd Positive_regulation of Ddc 1 0.01 0.38 0.25
24 INT138088 Ddc Regulation of Transcription of Nr4a1 1 0.02 0.16 0.24
25 INT336561 Binding of DDC and DIO2 1 0.04 0.27 0.24
26 INT164 Ddc Negative_regulation of Prl 1 0.06 0 0.23
27 INT335888 Lrp5 Negative_regulation of Gene_expression of Tph1 1 0.22 0.15 0.21
28 INT208763 Binding of CSF2 and TPH1 1 0.07 0.65 0.19
29 INT342744 Ddc Regulation of Trh 1 0.02 0.37 0.18
30 INT157097 Ddc Positive_regulation of Drd3 1 0.30 0.88 0.16
31 INT99084 Ddc Positive_regulation of Pdyn 2 0.15 0.87 0.14
32 INT99085 Ddc Positive_regulation of Transcription of Pdyn 1 0.15 0.31 0.11
33 INT325766 Binding of Ddc and Omd 1 0.01 0.59 0.04
34 INT105726 Ddc Positive_regulation of Gene_expression of Pdyn 1 0.04 0.62 0.04
35 INT281125 Binding of Ddc and Cd4 1 0.09 0.37 0.03
36 INT129864 Ddc Positive_regulation of Gene_expression of Fosb 1 0.02 0.13 0
37 INT258614 Positive_regulation of Binding of Foxn1 and Tph2 1 0.46 0.06 0
38 INT258615 Binding of Foxn1 and Tph2 1 0.44 0.06 0
39 INT145555 Ddc Positive_regulation of Phosphorylation of Mapk1 1 0.03 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for serotonin biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in serotonin biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT67 Negative_regulation of Ddc 66 0.59 15.34 28.96
2 INT6230 Localization of Ddc 40 0.79 13.11 20.88
3 INT149015 Gene_expression of Tph2 20 0.78 9.45 10.4
4 INT9027 Positive_regulation of Ddc 24 0.66 6.04 10.19
5 INT115296 Gene_expression of TPH1 18 0.77 7.46 10.18
6 INT53062 Gene_expression of Ddc 31 0.77 11.59 9.63
7 INT220 Negative_regulation of Ddc 16 0.59 2.94 8.66
8 INT47811 Positive_regulation of Localization of Ddc 11 0.69 4 7.6
9 INT4284 Regulation of Ddc 17 0.43 8.17 7.31
10 INT167457 Negative_regulation of Gene_expression of Tph2 5 0.57 2.27 5.9
11 INT144735 Gene_expression of DDC 8 0.75 3.21 5.31
12 INT126659 Gene_expression of Tph1 22 0.78 2.04 4.04
13 INT149795 Gene_expression of Ddc 8 0.73 1.5 3.06
14 INT137301 Negative_regulation of Gene_expression of TPH1 5 0.12 1.49 2.98
15 INT47812 Negative_regulation of Localization of Ddc 5 0.51 1.99 2.8
16 INT16406 Positive_regulation of Negative_regulation of Ddc 6 0.67 0.53 2.6
17 INT248419 Negative_regulation of Tph2 11 0.59 6.32 2.59
18 INT115298 Regulation of Gene_expression of TPH1 1 0.22 2.36 2.33
19 INT61011 Regulation of TPH1 4 0.22 1.17 2.09
20 INT14360 Positive_regulation of DDC 7 0.70 2.97 2.02
21 INT157095 Binding of Ddc 5 0.27 4.6 2
22 INT243846 Localization of DDC 3 0.63 0.66 1.99
23 INT248418 Localization of Tph2 5 0.75 2.45 1.45
24 INT126660 Positive_regulation of Gene_expression of Tph1 5 0.50 0.07 1.43
25 INT82676 Negative_regulation of Gene_expression of Ddc 4 0.55 0.55 1.43
26 INT333291 Positive_regulation of Gene_expression of DDC 1 0.49 0.13 1.35
27 INT121136 Negative_regulation of DDC 4 0.57 2.98 1.32
28 INT4480 Positive_regulation of Ddc 3 0.39 0.53 1.3
29 INT122745 Negative_regulation of TPH1 6 0.59 2.94 1.2
30 INT115294 Regulation of Regulation of TPH1 2 0.10 1 0.98
31 INT248421 Regulation of Tph1 1 0.27 0.89 0.87
32 INT344348 Transcription of Tph2 1 0.71 0.98 0.87
33 INT86036 Negative_regulation of Positive_regulation of Ddc 2 0.35 0.42 0.8
34 INT344349 Positive_regulation of Gene_expression of Tph2 1 0.46 0.77 0.8
35 INT208774 Positive_regulation of TPH1 2 0.50 0.71 0.78
36 INT344350 Positive_regulation of Tph2 1 0.69 0.82 0.78
37 INT149014 Negative_regulation of Tph1 5 0.58 1.43 0.74
38 INT87728 Regulation of Gene_expression of Ddc 4 0.25 1.1 0.71
39 INT258710 Regulation of Negative_regulation of Ddc 2 0.25 1.28 0.66
40 INT149013 Positive_regulation of Tph1 3 0.47 1.1 0.65
41 INT232442 Negative_regulation of Gene_expression of DDC 1 0.05 1.44 0.58
42 INT61009 Negative_regulation of Regulation of TPH1 1 0.00 0 0.5
43 INT144737 Regulation of Gene_expression of DDC 1 0.06 0 0.49
44 INT258772 Regulation of DDC 1 0.36 0.05 0.4
45 INT353976 Negative_regulation of Negative_regulation of Tph2 1 0.42 0 0.35
46 INT248415 Binding of Tph2 9 0.44 3.88 0.34
47 INT332750 Regulation of Gene_expression of Tph1 1 0.11 0 0.33
48 INT325303 Binding of DDC 3 0.30 1.04 0.28
49 INT268069 Regulation of Tph2 1 0.44 0.26 0.28
50 INT353977 Regulation of Gene_expression of Tph2 1 0.26 0 0.24
51 INT258091 Localization of Ddc 1 0.08 0.12 0.22
52 INT342740 Positive_regulation of Binding of Ddc 1 0.03 0.1 0.22
53 INT149796 Regulation of Gene_expression of Ddc 2 0.42 0.09 0.21
54 INT335879 Negative_regulation of Gene_expression of Tph1 1 0.19 0.15 0.21
55 INT184904 Regulation of Ddc 1 0.24 0.06 0.19
56 INT248417 Binding of Tph1 1 0.37 1.16 0.16
57 INT258692 Transcription of Ddc 1 0.67 0.29 0.14
58 INT248416 Phosphorylation of Tph1 1 0.80 1.04 0.13
59 INT248422 Negative_regulation of Phosphorylation of Tph1 1 0.42 1.04 0.13
60 INT14359 Regulation of Positive_regulation of DDC 1 0.45 0.92 0.12
61 INT325760 Phosphorylation of Ddc 1 0.27 0.06 0.12
62 INT248420 Negative_regulation of Phosphorylation of Tph2 1 0.43 0.99 0.11
63 INT248423 Phosphorylation of Tph2 1 0.81 0.99 0.11
64 INT208775 Binding of TPH1 1 0.37 0.61 0.1
65 INT258696 Negative_regulation of Transcription of Ddc 1 0.55 0.11 0.09
66 INT268076 Positive_regulation of Positive_regulation of Tph1 1 0.28 0.83 0.08
67 INT200429 Positive_regulation of Negative_regulation of TPH1 1 0.01 0.24 0.07
68 INT353974 Negative_regulation of Gene_expression of Ddc 1 0.35 0.21 0.05
69 INT258699 Regulation of Transcription of Ddc 1 0.57 0 0.03
70 INT138234 Transcription of Tph1 1 0.66 0 0
71 INT258702 Positive_regulation of Transcription of Ddc 1 0.43 0.05 0
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