GO:0042445

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Name hormone metabolic process
Categary Process
Go Slim No
Go Link GO:0042445
Unique Molecular Interactions 658
Total Molecular Interactions 960
Total Single Events 6113
Pain Genes Associated 19

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for hormone metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for hormone metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT83169 Binding of Cck and Lep 7 0.42 1.58 2.78
2 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
3 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
4 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36
5 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
6 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
7 INT83170 Lep Regulation of Cck 5 0.43 0.68 1.96
8 INT355251 Cacna1a Regulation of Gene_expression of Gabrg1 1 0.01 0.06 1.86
9 INT355249 Cacna1a Regulation of Gene_expression of Ltp 1 0.04 0.06 1.86
10 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
11 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
12 INT355254 Ltp Regulation of Cacna1a 1 0.04 0 1.58
13 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
14 INT74843 Binding of Cacna1a and Ea2 3 0.13 3.29 1.55
15 INT355250 Ltp Regulation of Positive_regulation of Cacna1a 1 0.04 0 1.39
16 INT355253 Ltp Positive_regulation of Cacna1a 1 0.05 0 1.34
17 INT355252 Binding of Cacna1a and Cnr1 1 0.04 0 1.31
18 INT74841 Binding of Cacna1a and Ea2 2 0.01 2.33 1.27
19 INT162482 Binding of Agt and Vta1 1 0.23 0 1.27
20 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
21 INT2457 Agt Positive_regulation of Localization of Avp 5 0.59 0.2 1.09
22 INT117311 HP Positive_regulation of Lep 1 0.00 1.78 1.01
23 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1
24 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96
25 INT108729 Binding of CACNA1A and Cacna1a 3 0.13 1.21 0.95
26 INT12050 Agt Positive_regulation of Localization of Oxt 1 0.29 0 0.91
27 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
28 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
29 INT69424 Binding of Agt and Oprd1 1 0.14 0 0.84
30 INT34458 AGT Negative_regulation of PENK 1 0.00 0 0.81
31 INT47143 Negative_regulation of Agt Positive_regulation of Avp 1 0.22 0 0.79
32 INT130948 Amt Regulation of Gene_expression of LEP 1 0.00 1.04 0.78
33 INT130949 Amt Regulation of LEP 1 0.00 1.04 0.77
34 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
35 INT214163 Binding of Lep and Nts 1 0.04 0.21 0.74
36 INT39095 Negative_regulation of Agt Positive_regulation of Localization of Ren 1 0.38 0 0.73
37 INT89009 Lep Positive_regulation of Cck 2 0.67 0.43 0.69
38 INT278956 LEP Regulation of Gene_expression of IL8 1 0.30 1.11 0.69
39 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69
40 INT278951 LEP Regulation of Gene_expression of PTGER2 1 0.07 1.11 0.69
41 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68
42 INT141063 Agt Regulation of Agtr1a 1 0.28 1.18 0.68
43 INT278965 LEP Positive_regulation of Gene_expression of NOS2 2 0.29 2.12 0.66
44 INT47145 Penk Negative_regulation of Agt 1 0.06 0 0.66
45 INT162878 Agt Regulation of Ang 1 0.21 1.15 0.66
46 INT31416 Cacna1a Positive_regulation of Gene_expression of Gcg 1 0.03 0 0.65
47 INT113780 AGT Positive_regulation of Positive_regulation of Nfkb1 1 0.00 1.25 0.64
48 INT57421 Oprd1 Regulation of Agt 1 0.29 0 0.62
49 INT61507 Ghrhr Positive_regulation of Localization of Gh1 1 0.41 0 0.61
50 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6
51 INT56116 Agt Positive_regulation of Lhb 1 0.15 0 0.58
52 INT349083 Binding of Lep and Rtn1 1 0.09 1.68 0.57
53 INT56117 Agt Positive_regulation of Positive_regulation of CGA 1 0.00 0 0.56
54 INT91339 Binding of Lep and Cck 1 0.28 0.34 0.56
55 INT113162 Lep Positive_regulation of Positive_regulation of Insrr 1 0.03 0 0.55
56 INT253834 Cck Regulation of Lep 1 0.19 0.23 0.55
57 INT129270 Binding of Wnt4 and Efs 1 0.00 0 0.55
58 INT204087 IL1B Positive_regulation of Gene_expression of LEP 1 0.09 2.6 0.54
59 INT73367 Agt Negative_regulation of Localization of Calca 1 0.43 0.26 0.54
60 INT34459 AGT Negative_regulation of MBTPS1 1 0.01 0 0.54
61 INT214160 Binding of Lep and Mc4r 1 0.29 1.31 0.53
62 INT214143 Binding of Lep and Pomc 1 0.27 1.2 0.53
63 INT132438 Binding of AGT and OXTR 1 0.08 1.03 0.53
64 INT256019 Agt Negative_regulation of Lnpep 1 0.23 1.76 0.53
65 INT19296 AGT Positive_regulation of Localization of AVP 1 0.38 0 0.5
66 INT21315 AGT Positive_regulation of Npy 1 0.03 0.15 0.5
67 INT354986 Cacna1a Regulation of Localization of Mpo 1 0.01 1.15 0.49
68 INT39078 Binding of Agt and Penk 1 0.24 0.42 0.48
69 INT162890 Negative_regulation of Binding of LEP and Tnf 1 0.03 0.49 0.48
70 INT162889 Binding of LEP and Tnf 1 0.03 0.49 0.48
71 INT47144 Negative_regulation of Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
72 INT47146 Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
73 INT39077 Agt Negative_regulation of Prss12 1 0.05 0.44 0.46
74 INT342633 ACE Regulation of Gene_expression of AGT 1 0.01 0.14 0.46
75 INT132509 Binding of LEP and Cck 1 0.13 0.16 0.45
76 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
77 INT151958 Negative_regulation of Agt Positive_regulation of Agtrap 1 0.39 0 0.44
78 INT151959 Agt Positive_regulation of Agtrap 1 0.63 0 0.44
79 INT114341 Agt Positive_regulation of AGT 3 0.01 1.15 0.43
80 INT184543 Agt Positive_regulation of Ccl2 1 0.16 3.18 0.43
81 INT345288 AGT Positive_regulation of Localization of CCL2 1 0.01 1.5 0.43
82 INT36459 Binding of Agt and Positive_regulation of Localization of Avp 1 0.38 0.19 0.43
83 INT345291 AGT Positive_regulation of CCL2 1 0.01 1.39 0.43
84 INT242992 Binding of Agt and Ppara 1 0.20 1.44 0.42
85 INT323880 Binding of BMI1 and LEP 1 0.02 3.97 0.41
86 INT83171 Cck Regulation of Lep 1 0.30 0.09 0.4
87 INT36460 Binding of Agt and Avp 1 0.28 0.16 0.4
88 INT354984 Binding of Cacna1a and Tnf 1 0.01 0.83 0.4
89 INT97395 Lep Positive_regulation of Stat3 1 0.67 0.42 0.4
90 INT275156 Agt Positive_regulation of Rac1 1 0.03 2.89 0.4
91 INT64384 Agt Negative_regulation of Son 1 0.26 0 0.39
92 INT143747 Binding of IL6 and LEP 2 0.04 4.05 0.38
93 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38
94 INT158355 Cacna1a Regulation of Alox5 1 0.01 0.7 0.37
95 INT300488 Binding of CRP and LEP 1 0.46 2.03 0.37
96 INT39092 Agt Negative_regulation of Ren 1 0.39 0 0.37
97 INT226785 Angpt2 Positive_regulation of Localization of Lep 1 0.01 1.65 0.36
98 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 0.16 0.62 0.36
99 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 0.42 0.63 0.36
100 INT53257 CALCRL Negative_regulation of Binding of Agt 1 0.00 0 0.36
101 INT323885 LEP Regulation of Gene_expression of NOS2 1 0.26 1.07 0.35
102 INT44112 Agt Regulation of Penk 1 0.08 0 0.35
103 INT213484 Binding of Lep and Pik3c3 1 0.01 0 0.35
104 INT230786 Binding of AGT and ACE 4 0.15 2.53 0.34
105 INT4638 Binding of Agt and Adarb1 3 0.01 0 0.34
106 INT330122 Agt Positive_regulation of Gene_expression of Agtr1a 1 0.03 0.69 0.34
107 INT354985 Cacna1a Regulation of Nos2 1 0.01 0.73 0.34
108 INT354982 Cacna1a Regulation of Tnf 1 0.00 0.73 0.34
109 INT330119 Agt Positive_regulation of Gene_expression of Bdkrb1 1 0.37 0.63 0.34
110 INT162157 Binding of SGCG and Agt 1 0.33 0.35 0.33
111 INT207184 Binding of Adipoq and Lep 1 0.25 2.45 0.33
112 INT147436 Agt Positive_regulation of Gene_expression of Ros1 1 0.02 0.5 0.33
113 INT323870 LEP Regulation of Gene_expression of MMP13 1 0.21 1.76 0.33
114 INT303993 Lep Positive_regulation of Gene_expression of IL2 1 0.15 0.24 0.33
115 INT242995 Agt Positive_regulation of Spp1 1 0.36 1.82 0.33
116 INT229363 Negative_regulation of Binding of Agt and Agtr1a 2 0.22 0.9 0.32
117 INT44127 Agt Negative_regulation of DSPP 1 0.02 0 0.32
118 INT56115 Agt Regulation of Lhb 1 0.16 0 0.32
119 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31
120 INT105873 Ins1 Negative_regulation of Positive_regulation of Lep 1 0.27 0.67 0.31
121 INT278942 LEP Regulation of IL6 1 0.29 0.61 0.31
122 INT278939 LEP Regulation of IL8 1 0.13 0.61 0.31
123 INT213485 Lep Positive_regulation of Localization of Grin2a 1 0.19 0 0.31
124 INT278969 LEP Regulation of PTGER2 1 0.03 0.6 0.31
125 INT105874 Lep Negative_regulation of Positive_regulation of Ins1 1 0.27 0.67 0.31
126 INT151258 Binding of Cacna1a and FCMTE1 1 0.00 0.57 0.3
127 INT226989 Lias Regulation of Gene_expression of Lep 1 0.10 0.91 0.3
128 INT278961 IL6 Regulation of Gene_expression of LEP 1 0.29 0.89 0.3
129 INT303983 Lep Positive_regulation of CXCL10 1 0.06 0.31 0.29
130 INT333886 Binding of Lep and Positive_regulation of Gene_expression of Nos2 1 0.39 0.73 0.29
131 INT303998 Lep Positive_regulation of Localization of IL1RAPL1 1 0.04 0.31 0.29
132 INT333887 Binding of Lep and Positive_regulation of Gene_expression of Il1 1 0.17 0.73 0.29
133 INT303995 Lep Positive_regulation of PSME1 1 0.09 0.32 0.29
134 INT200631 AGT Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
135 INT288911 AGT Positive_regulation of CYBB 3 0.07 2.96 0.28
136 INT116853 Chdh Regulation of Positive_regulation of Agt 1 0.11 0.19 0.28
137 INT303984 Lep Positive_regulation of Gene_expression of IL8 1 0.06 0.85 0.28
138 INT45541 Agt Positive_regulation of Lnpep 1 0.03 0 0.27
139 INT45545 Agt Positive_regulation of Oxt 1 0.23 0 0.27
140 INT142003 Binding of Cacna1a and Etax2 1 0.00 1.02 0.26
141 INT100531 Cck Positive_regulation of Lep 1 0.70 0.15 0.26
142 INT142004 Binding of Cacna1a and TGM6 1 0.00 1.02 0.26
143 INT126550 Agt Positive_regulation of Gene_expression of Nsfl1c 1 0.39 1.07 0.26
144 INT242991 Agt Positive_regulation of Gene_expression of Spp1 1 0.21 0.66 0.26
145 INT9528 Agt Positive_regulation of Localization of Pomc 2 0.50 0.14 0.25
146 INT228611 Binding of DNMT3B and LEP 1 0.04 0 0.25
147 INT342456 AGT Positive_regulation of Gene_expression of CCL2 1 0.07 0.63 0.25
148 INT218732 Lep Regulation of Gene_expression of Trh 1 0.19 0.18 0.25
149 INT126547 Agt Positive_regulation of Nfkb1 1 0.46 0.99 0.25
150 INT126548 Negative_regulation of Agt Positive_regulation of Nfkb1 1 0.29 0.99 0.25
151 INT297258 Binding of Agt and Agtr2 1 0.23 0.7 0.25
152 INT294514 Safb Positive_regulation of Localization of Hand1 1 0.08 0.38 0.25
153 INT126553 Agt Positive_regulation of Nfkb1 1 0.06 0.99 0.25
154 INT256028 Binding of Agt and Lnpep 1 0.19 1.16 0.24
155 INT41588 Binding of AGT and Lhb 1 0.00 0 0.24
156 INT125748 Binding of LEP and Gh 1 0.00 0.52 0.24
157 INT41589 Binding of AGT and Prl 1 0.00 0 0.24
158 INT126551 Agt Positive_regulation of Gene_expression of Ptgs1 1 0.25 0.92 0.24
159 INT126552 Agt Positive_regulation of Gene_expression of Ptgs2 1 0.32 0.92 0.24
160 INT191492 Binding of AGT and NLRP3 1 0.01 0.35 0.23
161 INT306795 Binding of LEP and SFTPD 1 0.08 1.13 0.23
162 INT303988 Lep Positive_regulation of Gene_expression of ISYNA1 1 0.06 0.55 0.23
163 INT126549 Agt Positive_regulation of Ptgs2 1 0.32 0.9 0.23
164 INT323883 BMI1 Regulation of LEP 1 0.02 2.39 0.23
165 INT102937 Gnrh1 Positive_regulation of Gene_expression of Lep 1 0.50 0 0.22
166 INT110653 Lep Regulation of Localization of Cck 1 0.06 0.22 0.22
167 INT269180 LEP Positive_regulation of Localization of TNF 1 0.01 0.99 0.21
168 INT323873 LEP Regulation of Gene_expression of TIMP2 1 0.31 0.63 0.21
169 INT309513 Binding of Xrcc6 and Htt 1 0.30 3.69 0.21
170 INT207185 Binding of Bmi1 and Lep 1 0.01 1.7 0.21
171 INT222566 Agt Positive_regulation of Localization of Prl 1 0.08 0.23 0.21
172 INT229360 Agt Positive_regulation of Agtr1a 2 0.48 1.26 0.2
173 INT222482 Lep Positive_regulation of Localization of Gh1 1 0.02 1.02 0.2
174 INT304001 Lep Negative_regulation of ICAM3 1 0.07 0.35 0.2
175 INT275159 Agt Positive_regulation of Phosphorylation of Stat3 1 0.04 1.44 0.2
176 INT333889 Lep Regulation of Col7a1 1 0.04 0.41 0.2
177 INT303979 Lep Positive_regulation of ITGB2 1 0.11 0.35 0.2
178 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
179 INT256576 Lep Regulation of Localization of Ins1 1 0.57 2.08 0.2
180 INT303991 Lep Negative_regulation of SELL 1 0.04 0.35 0.2
181 INT249993 Binding of Agt and Igkv4-55 1 0.02 0.49 0.2
182 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19
183 INT217661 LEP Positive_regulation of INS 2 0.25 1.85 0.19
184 INT327814 Rab8a Regulation of Regulation of Lep 1 0.01 0.15 0.19
185 INT327813 Rab8a Regulation of Lep 1 0.01 0.15 0.19
186 INT303964 Lep Positive_regulation of Icam1 1 0.24 0.35 0.19
187 INT333888 Lep Regulation of Localization of GAG 1 0.68 0.38 0.19
188 INT321915 Binding of DAO and Ddo 1 0.07 0 0.19
189 INT321914 Negative_regulation of Binding of Ddo and GRIN3B 1 0.01 0 0.19
190 INT289251 Ptpn11 Regulation of Il6 1 0.09 0.86 0.18
191 INT184540 Agt Regulation of Gene_expression of Ccl2 1 0.08 1.66 0.18
192 INT214170 Binding of DST and Lep 1 0.02 0.17 0.18
193 INT41978 Binding of Agt and Htr1a 1 0.41 0.54 0.18
194 INT303981 Lep Positive_regulation of Localization of CXCL1 1 0.02 0.34 0.18
195 INT229223 Binding of AGT and FAS 1 0.08 0.91 0.17
196 INT36568 AGT Positive_regulation of FBF1 1 0.39 0.5 0.17
197 INT226988 Lias Positive_regulation of Localization of Lep 1 0.08 0.3 0.17
198 INT233904 NLRP3 Positive_regulation of AGT 1 0.06 0.81 0.17
199 INT229224 Positive_regulation of Binding of AGT and FAS 1 0.09 0.92 0.17
200 INT243772 Safb Negative_regulation of Gria1 1 0.23 0.84 0.17

Single Events

The table below shows the top 100 pain related interactions that have been reported for hormone metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in hormone metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31
2 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32
3 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1
4 INT385 Gene_expression of Agt 182 0.78 63.62 37.91
5 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08
6 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
7 INT1158 Regulation of Agt 106 0.61 29.4 30.29
8 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2
9 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12
10 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76
11 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
12 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
13 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22
14 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35
15 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92
16 INT2066 Localization of Agt 56 0.80 9.95 16.25
17 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77
18 INT75908 Regulation of LEP 77 0.60 60.16 15.19
19 INT3962 Regulation of AGT 50 0.62 20.96 13.01
20 INT4199 Binding of Agt 76 0.48 21.06 12.66
21 INT73641 Regulation of Lep 45 0.62 26.2 12.59
22 INT30101 Regulation of Cacna1a 25 0.45 14.38 12.43
23 INT398 Localization of AGT 45 0.78 16.97 11.54
24 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17
25 INT82079 Positive_regulation of Lep 79 0.70 40 11.07
26 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91
27 INT8065 Binding of AGT 54 0.48 20.54 10.85
28 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95
29 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38
30 INT386 Positive_regulation of Gene_expression of Agt 37 0.70 15.92 8.73
31 INT82082 Localization of Lep 63 0.81 26.41 8.56
32 INT75907 Binding of LEP 53 0.46 46.65 8.44
33 INT91821 Binding of Cacna1a 16 0.48 13.1 6.37
34 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14
35 INT5762 Negative_regulation of Gene_expression of Agt 18 0.57 6.09 5.84
36 INT146594 Negative_regulation of Gene_expression of LEP 25 0.42 18.88 5.71
37 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65
38 INT65356 Localization of LEP 46 0.79 41.17 5.43
39 INT91338 Binding of Lep 31 0.48 26.86 5.39
40 INT102935 Regulation of Lep 31 0.60 18.47 5.24
41 INT129508 Localization of Cacna1a 7 0.74 6.47 5.13
42 INT110796 Positive_regulation of Positive_regulation of Cacna1a 1 0.49 0.51 4.84
43 INT97391 Binding of Lep 18 0.48 8.97 4.47
44 INT3332 Protein_catabolism of AGT 23 0.87 3.17 4.39
45 INT82731 Transcription of Cacna1a 5 0.56 3.41 4.27
46 INT163581 Localization of Lep 27 0.79 18.99 4.08
47 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75
48 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72
49 INT82077 Positive_regulation of Gene_expression of Lep 32 0.70 17.9 3.5
50 INT94045 Regulation of Cacna1a 5 0.42 3.56 3.33
51 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03
52 INT85572 Gene_expression of Cacna1a 11 0.66 5.72 3.02
53 INT142940 Positive_regulation of Negative_regulation of Cacna1a 3 0.50 1.65 2.97
54 INT58720 Negative_regulation of SAFB 4 0.50 0.19 2.69
55 INT355244 Negative_regulation of Negative_regulation of Cacna1a 1 0.04 0 2.67
56 INT97443 Positive_regulation of Positive_regulation of LEP 13 0.50 11.91 2.65
57 INT1540 Positive_regulation of SAFB 9 0.43 1.97 2.56
58 INT17857 Negative_regulation of Gene_expression of AGT 25 0.46 21.16 2.45
59 INT148071 Gene_expression of Agt 42 0.74 44.9 2.43
60 INT4270 Negative_regulation of Negative_regulation of Agt 10 0.43 1.08 2.43
61 INT103487 Positive_regulation of Positive_regulation of Lep 9 0.67 4.08 2.38
62 INT27988 Negative_regulation of Positive_regulation of AGT 11 0.42 5.71 2.27
63 INT10201 Positive_regulation of Localization of Agt 8 0.50 0.97 2.21
64 INT82081 Regulation of Gene_expression of Lep 11 0.53 7.78 2.12
65 INT110795 Regulation of Positive_regulation of Cacna1a 2 0.26 0.65 2.07
66 INT12005 Negative_regulation of Localization of Agt 6 0.57 1.49 2.06
67 INT83392 Transcription of Lep 6 0.54 5.07 2.04
68 INT79915 Positive_regulation of Agt 27 0.56 12.97 1.96
69 INT12801 Negative_regulation of Regulation of Agt 4 0.43 1.2 1.96
70 INT43944 Negative_regulation of Positive_regulation of Agt 4 0.42 1.44 1.93
71 INT354979 Positive_regulation of Localization of Cacna1a 2 0.05 0.86 1.79
72 INT355239 Negative_regulation of Positive_regulation of Cacna1a 1 0.04 0 1.79
73 INT15980 Positive_regulation of Positive_regulation of Agt 6 0.50 2.99 1.76
74 INT82083 Negative_regulation of Gene_expression of Lep 12 0.56 8.07 1.75
75 INT294504 Gene_expression of Safb 9 0.41 0.97 1.72
76 INT71327 Localization of Cacna1a 3 0.60 2.51 1.7
77 INT3152 Transcription of Agt 7 0.72 5.09 1.68
78 INT355242 Negative_regulation of Binding of Cacna1a 1 0.04 0.17 1.47
79 INT214115 Regulation of Gene_expression of Lep 9 0.61 7.37 1.44
80 INT355245 Regulation of Localization of Cacna1a 1 0.04 0 1.43
81 INT34768 Negative_regulation of Negative_regulation of AGT 10 0.25 2.79 1.42
82 INT8067 Negative_regulation of Binding of AGT 12 0.25 10.33 1.39
83 INT90740 Negative_regulation of Cacna1a 3 0.23 1.43 1.38
84 INT239215 Binding of Agt 9 0.38 6.75 1.35
85 INT11306 Regulation of Gene_expression of Agt 7 0.45 3.29 1.31
86 INT11241 Transcription of AGT 4 0.52 1.83 1.27
87 INT82727 Positive_regulation of Transcription of Cacna1a 1 0.01 1.07 1.25
88 INT19319 Negative_regulation of Binding of Agt 9 0.42 3.42 1.24
89 INT243771 Negative_regulation of Safb 7 0.26 0.77 1.23
90 INT79916 Negative_regulation of Agt 14 0.47 6 1.22
91 INT47644 Positive_regulation of Localization of AGT 4 0.45 1.24 1.2
92 INT167270 Negative_regulation of Gene_expression of Lep 13 0.55 5.48 1.19
93 INT85571 Positive_regulation of Cacna1a 3 0.50 2.06 1.18
94 INT355243 Negative_regulation of Regulation of Cacna1a 1 0.04 0 1.16
95 INT213465 Transcription of Lep 4 0.68 2.11 1.15
96 INT28594 Positive_regulation of Transcription of Agt 2 0.47 1.3 1.15
97 INT115621 Positive_regulation of Binding of AGT 1 0.02 0 1.15
98 INT253813 Regulation of Negative_regulation of Lep 2 0.45 1.01 1.12
99 INT82084 Positive_regulation of Localization of Lep 11 0.70 4.65 1.11
100 INT108997 Localization of Htt 28 0.77 3.76 1.07
101 INT254875 Positive_regulation of Htt 10 0.47 4.07 0.96
102 INT321650 Negative_regulation of Gene_expression of Cacna1a 2 0.04 0.13 0.95
103 INT94046 Protein_catabolism of Cacna1a 1 0.70 0.83 0.9
104 INT117308 Negative_regulation of Localization of Lep 3 0.59 2.16 0.86
105 INT230806 Positive_regulation of Gene_expression of Agt 11 0.55 16.08 0.83
106 INT333883 Positive_regulation of Positive_regulation of Lep 2 0.46 1.06 0.83
107 INT154886 Gene_expression of Htt 18 0.76 15.51 0.82
108 INT27135 Gene_expression of SAFB 9 0.68 0.96 0.79
109 INT82080 Regulation of Localization of Lep 2 0.45 1.36 0.76
110 INT21943 Positive_regulation of Positive_regulation of AGT 6 0.46 3.29 0.75
111 INT34715 Regulation of Regulation of AGT 2 0.37 0.96 0.75
112 INT156533 Transcription of LEP 9 0.69 4.35 0.74
113 INT213471 Positive_regulation of Localization of Lep 4 0.48 2.65 0.74
114 INT42722 Negative_regulation of Ptpn11 1 0.21 0 0.71
115 INT148074 Regulation of Agt 9 0.49 5.42 0.7
116 INT38735 Protein_catabolism of Agt 7 0.99 2.79 0.7
117 INT160461 Phosphorylation of Agt 1 0.31 0.4 0.7
118 INT160463 Positive_regulation of Phosphorylation of Agt 1 0.19 0.41 0.7
119 INT86127 Positive_regulation of Safb 5 0.50 0.35 0.68
120 INT103336 Transcription of Cacna1a 2 0.69 1.17 0.68
121 INT34769 Regulation of Gene_expression of AGT 3 0.19 1.39 0.67
122 INT101484 Regulation of Positive_regulation of Lep 3 0.45 1.68 0.61
123 INT283070 Localization of Safb 2 0.43 1.21 0.61
124 INT61506 Localization of Ghrhr 1 0.51 0 0.61
125 INT98239 Negative_regulation of Htt 13 0.43 7.84 0.6
126 INT345957 Positive_regulation of Binding of Lep 2 0.38 2.03 0.6
127 INT83391 Negative_regulation of Transcription of Lep 1 0.43 0.34 0.6
128 INT306798 Protein_catabolism of LEP 1 0.65 2.45 0.58
129 INT287206 Regulation of Gene_expression of Htt 6 0.50 3.27 0.57
130 INT215340 Localization of Htt 10 0.61 5.12 0.55
131 INT287204 Protein_catabolism of Htt 6 0.99 2.8 0.53
132 INT40021 Regulation of Binding of Agt 4 0.59 1.53 0.53
133 INT32618 Regulation of Positive_regulation of Agt 2 0.43 0.42 0.52
134 INT119230 Negative_regulation of Htt 5 0.42 2.99 0.5
135 INT47645 Negative_regulation of Localization of AGT 2 0.11 1.09 0.49
136 INT82819 Negative_regulation of Negative_regulation of LEP 3 0.56 2.22 0.46
137 INT99588 Positive_regulation of Binding of Agt 2 0.69 0.23 0.45
138 INT243418 Binding of Htt 14 0.30 5.94 0.44
139 INT165597 Positive_regulation of Htt 8 0.60 4.27 0.44
140 INT305077 Localization of CRHBP 1 0.76 0.28 0.44
141 INT14039 Regulation of Regulation of Agt 1 0.30 0 0.44
142 INT33017 Negative_regulation of Protein_catabolism of AGT 3 0.37 0 0.42
143 INT102934 Positive_regulation of Regulation of Lep 2 0.50 0.55 0.42
144 INT323765 Negative_regulation of Binding of Lep 1 0.37 0.91 0.42
145 INT187726 Positive_regulation of Localization of LEP 5 0.50 5.31 0.41
146 INT132864 Binding of Htt 15 0.46 2.34 0.38
147 INT117096 Gene_expression of Wnt4 2 0.67 4.68 0.38
148 INT287207 Regulation of Protein_catabolism of Htt 3 0.45 1.73 0.35
149 INT95605 Regulation of Binding of AGT 3 0.44 0.2 0.34
150 INT27928 Phosphorylation of AGT 1 0.52 0.15 0.34
151 INT99962 Positive_regulation of Gene_expression of Cacna1a 1 0.01 1.1 0.34
152 INT27929 Negative_regulation of Phosphorylation of AGT 1 0.27 0.15 0.34
153 INT303962 Phosphorylation of Lep 2 0.80 5.2 0.31
154 INT213467 Negative_regulation of Localization of Lep 2 0.40 1.11 0.31
155 INT4636 Positive_regulation of Regulation of Agt 4 0.50 1.3 0.3
156 INT156534 Positive_regulation of Transcription of LEP 1 0.14 0.34 0.3
157 INT43398 Regulation of Localization of Agt 1 0.28 0 0.3
158 INT141781 Positive_regulation of Negative_regulation of LEP 1 0.46 0.37 0.29
159 INT254877 Positive_regulation of Gene_expression of Htt 15 0.64 6.29 0.28
160 INT247097 Binding of CRHBP 3 0.34 0.4 0.28
161 INT294497 Positive_regulation of Localization of Safb 1 0.27 0.32 0.28
162 INT3331 Positive_regulation of Protein_catabolism of AGT 1 0.33 0 0.27
163 INT164617 Protein_catabolism of Agt 2 0.79 5.3 0.25
164 INT356310 Regulation of Safb 1 0.06 0 0.24
165 INT150977 Regulation of Regulation of LEP 3 0.37 2.07 0.23
166 INT239213 Localization of Agt 6 0.64 3.26 0.22
167 INT287205 Regulation of Htt 5 0.45 3.56 0.22
168 INT142417 Positive_regulation of Transcription of Lep 2 0.52 2.63 0.22
169 INT230802 Positive_regulation of Positive_regulation of Agt 2 0.40 0.41 0.2
170 INT289228 Localization of Ptpn11 1 0.15 0.87 0.18
171 INT163816 Phosphorylation of Lep 2 0.63 2.2 0.17
172 INT1770 Positive_regulation of Negative_regulation of Agt 2 0.49 1.09 0.17
173 INT256015 Negative_regulation of Regulation of Agt 1 0.18 0.16 0.17
174 INT333880 Protein_catabolism of Lep 1 0.65 0.34 0.17
175 INT79914 Positive_regulation of Negative_regulation of Agt 1 0.50 0.19 0.17
176 INT157134 Regulation of Localization of LEP 1 0.09 0.5 0.16
177 INT321896 Binding of Ddo 1 0.08 0 0.16
178 INT333882 Regulation of Binding of Lep 1 0.45 0.07 0.16
179 INT204088 Regulation of Negative_regulation of LEP 1 0.59 1.16 0.16
180 INT300489 Negative_regulation of Binding of LEP 1 0.41 1.12 0.15
181 INT278979 Negative_regulation of Positive_regulation of LEP 2 0.40 0.81 0.14
182 INT187723 Regulation of Positive_regulation of LEP 3 0.42 2.29 0.13
183 INT256004 Negative_regulation of Gene_expression of Agt 2 0.34 8.07 0.13
184 INT239214 Positive_regulation of Localization of Agt 2 0.55 1.89 0.13
185 INT323898 Regulation of Phosphorylation of LEP 1 0.42 1.25 0.13
186 INT323895 Phosphorylation of LEP 1 0.76 1.23 0.13
187 INT119156 Positive_regulation of Protein_catabolism of Agt 1 0.49 0 0.13
188 INT214619 Positive_regulation of Negative_regulation of AGT 1 0.04 0.98 0.13
189 INT157241 Negative_regulation of Localization of LEP 5 0.56 2.1 0.12
190 INT184029 Binding of Ptpn11 2 0.19 0.18 0.12
191 INT316643 Negative_regulation of Gene_expression of Safb 1 0.13 0.08 0.12
192 INT163815 Negative_regulation of Negative_regulation of Lep 1 0.43 0.32 0.12
193 INT256008 Regulation of Gene_expression of Agt 4 0.36 5.03 0.11
194 INT226984 Regulation of Transcription of Lep 1 0.27 0.3 0.11
195 INT295368 Localization of Ptpn11 1 0.25 0 0.11
196 INT213470 Positive_regulation of Ptpn11 1 0.05 0.07 0.1
197 INT262892 Gene_expression of Ghrhr 1 0.20 1.93 0.1
198 INT176587 Positive_regulation of Positive_regulation of SAFB 1 0.01 0.25 0.09
199 INT213468 Regulation of Ptpn11 1 0.05 0.08 0.09
200 INT50849 Negative_regulation of Regulation of AGT 2 0.42 1.26 0.08
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