GO:0042446

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Name hormone biosynthetic process
Categary Process
Go Slim No
Go Link GO:0042446
Unique Molecular Interactions 45
Total Molecular Interactions 59
Total Single Events 486
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for hormone biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for hormone biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT349608 Binding of DIO2 and LMOD1 1 0.23 0.41 2.01
2 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
3 INT63490 Negative_regulation of Dio1 Positive_regulation of Rtcd1 1 0.01 0.58 1.51
4 INT63489 Dio1 Positive_regulation of Rtcd1 1 0.01 0.58 1.51
5 INT111760 Dio1 Positive_regulation of Binding of Cpe 1 0.04 0.34 1.44
6 INT111756 Dio1 Positive_regulation of Cpe 1 0.04 0.34 1.42
7 INT353372 Dio1 Positive_regulation of Grin1 1 0.16 0 0.98
8 INT210984 Cfp Positive_regulation of Positive_regulation of Dio1 1 0.07 0.81 0.75
9 INT210980 Cysltr1 Positive_regulation of Positive_regulation of Dio1 1 0.00 0.81 0.75
10 INT200913 Dio1 Positive_regulation of Mapk8 1 0.00 0 0.53
11 INT5112 DIO2 Positive_regulation of Positive_regulation of Gal 1 0.27 0 0.53
12 INT5111 DIO2 Positive_regulation of Drd1a 1 0.04 0 0.53
13 INT151338 Binding of Dio1 and P9Ehs1 1 0.09 0.16 0.52
14 INT228850 Dio1 Positive_regulation of Phosphorylation of Ppp1r1b 1 0.06 0 0.44
15 INT342998 DUOX1 Positive_regulation of ROS1 1 0.23 0.25 0.43
16 INT68526 Binding of ADCY1 and DIO2 1 0.01 0.07 0.41
17 INT50621 Positive_regulation of Dio1 Positive_regulation of Gene_expression of Fos 1 0.43 0 0.37
18 INT39594 TPO Positive_regulation of CALR 1 0.30 0.91 0.32
19 INT326438 Binding of HFE and TAPVR1 1 0.01 0.48 0.29
20 INT33977 DIO2 Regulation of PCDHB17 1 0.00 0.44 0.27
21 INT356094 Binding of App and Tg 1 0.08 0.12 0.26
22 INT34784 DIO2 Regulation of Localization of GHRH 1 0.00 0 0.25
23 INT34785 DIO2 Positive_regulation of Localization of GHRH 1 0.01 0 0.25
24 INT336561 Binding of DDC and DIO2 1 0.04 0.27 0.24
25 INT50620 Dio1 Positive_regulation of Gene_expression of Fos 1 0.43 0 0.22
26 INT266005 Binding of DIO3 and SGCG 1 0.00 0.86 0.22
27 INT356089 Positive_regulation of Binding of Tg and Rab11a 1 0.00 0.07 0.21
28 INT356099 Binding of Tg and Rab11a 1 0.00 0.07 0.21
29 INT244855 Lbx1 Negative_regulation of Dio1 1 0.03 0.09 0.16
30 INT266003 Binding of COL5A2 and DIO3 1 0.01 0.43 0.11
31 INT342288 Binding of CD4 and HFE 1 0.01 1.26 0.08
32 INT319786 Ccbp2 Positive_regulation of Negative_regulation of Dio1 1 0.09 0.94 0.05
33 INT286228 Binding of Tpo and Ceat1 1 0.00 1.28 0.04
34 INT202573 Binding of DIO2 and DRD4 1 0.07 0.09 0.03
35 INT319787 Binding of Dio1 and Ccbp2 1 0.06 0.92 0.03
36 INT276136 Binding of DIO2 and HLA-E 1 0.26 0 0
37 INT215766 Dio1 Regulation of Cdk6 1 0.01 0.05 0
38 INT325900 Binding of Dio1 and Wbp5 1 0.00 0.25 0
39 INT286229 Psmb9 Regulation of Tpo 1 0.07 1.01 0
40 INT215764 Dio1 Regulation of Ces1c 1 0.00 0.05 0
41 INT215768 Dio1 Regulation of Cdk4 1 0.01 0.05 0
42 INT275232 DUOX2 Positive_regulation of ROS1 1 0.10 0.33 0
43 INT325901 Binding of Dio1 and F2 1 0.01 0.63 0
44 INT269770 Binding of DIO2 and NOVA2 1 0.07 0 0
45 INT242858 Binding of HFE and INS 1 0.06 1.64 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for hormone biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in hormone biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT50618 Gene_expression of Dio1 48 0.74 17.37 15.91
2 INT6749 Binding of Dio1 25 0.38 4.41 13.07
3 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61
4 INT27507 Positive_regulation of Dio1 23 0.44 3.43 12.11
5 INT6748 Regulation of Dio1 15 0.45 2.63 11.18
6 INT31780 Binding of DIO2 17 0.36 10.07 10
7 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46
8 INT52465 Negative_regulation of Dio1 17 0.58 4.45 7.76
9 INT29794 Regulation of DIO2 13 0.44 5.02 6.84
10 INT95759 Gene_expression of DIO3 5 0.51 2.55 5.28
11 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51
12 INT27316 Negative_regulation of TPO 7 0.38 7.26 4.42
13 INT202577 Localization of DIO2 9 0.56 1.3 2.97
14 INT90981 Transcription of Dio1 2 0.42 1.44 2.85
15 INT229110 Positive_regulation of Positive_regulation of DIO2 3 0.26 1.08 2.31
16 INT27315 Positive_regulation of TPO 17 0.45 9.84 2.28
17 INT97308 Gene_expression of TPO 15 0.65 13.26 2.12
18 INT167699 Positive_regulation of Positive_regulation of Dio1 2 0.26 1.12 2.04
19 INT122895 Transcription of DIO2 3 0.52 0.91 1.73
20 INT58456 Gene_expression of HFE 10 0.58 7.68 1.65
21 INT143317 Regulation of Gene_expression of Dio1 4 0.26 2.9 1.4
22 INT147345 Localization of Dio1 7 0.50 1.72 1.38
23 INT143233 Positive_regulation of Binding of Dio1 1 0.21 0 1.36
24 INT103272 Positive_regulation of Gene_expression of Dio1 4 0.26 1.66 1.34
25 INT122894 Transcription of DIO3 1 0.52 0.71 1.19
26 INT55699 Regulation of Binding of DIO2 2 0.24 1.91 1.16
27 INT86834 Positive_regulation of Tg 10 0.69 4.9 1.04
28 INT58457 Positive_regulation of HFE 3 0.28 2.75 1.04
29 INT40540 Localization of DIO3 2 0.73 1.11 0.96
30 INT151336 Regulation of Binding of Dio1 2 0.30 0.2 0.9
31 INT7619 Regulation of TPO 3 0.24 3.09 0.89
32 INT7620 Localization of TPO 4 0.26 5.35 0.88
33 INT63486 Negative_regulation of Positive_regulation of Dio1 1 0.19 0.33 0.79
34 INT20993 Negative_regulation of DUOX1 1 0.00 0 0.69
35 INT154706 Gene_expression of Tg 9 0.38 4.95 0.64
36 INT335719 Positive_regulation of Gene_expression of DIO2 3 0.23 0.59 0.61
37 INT257949 Regulation of Gene_expression of DIO2 1 0.15 0.17 0.6
38 INT150155 Binding of TPO 3 0.30 3.98 0.58
39 INT200875 Protein_catabolism of Dio1 1 0.03 0 0.57
40 INT257946 Regulation of Positive_regulation of DIO2 1 0.13 0.45 0.49
41 INT39018 Protein_catabolism of DIO2 1 0.02 0 0.49
42 INT349611 Positive_regulation of Localization of DIO2 1 0.26 0 0.46
43 INT36686 Regulation of Tg 7 0.19 3.12 0.45
44 INT40541 Negative_regulation of Positive_regulation of DIO2 2 0.41 0.86 0.4
45 INT319780 Negative_regulation of Gene_expression of Dio1 2 0.31 1.51 0.4
46 INT347801 Regulation of Regulation of Dio1 1 0.15 0.55 0.39
47 INT228849 Negative_regulation of Binding of Dio1 1 0.06 0 0.36
48 INT77362 Localization of DUOX1 1 0.06 0 0.3
49 INT150594 Negative_regulation of HFE 1 0.00 0 0.2
50 INT286205 Gene_expression of Tpo 1 0.09 2.32 0.18
51 INT107861 Gene_expression of DUOX1 1 0.70 0.17 0.17
52 INT349614 Negative_regulation of Binding of DIO2 1 0.27 0.77 0.16
53 INT286194 Positive_regulation of Gene_expression of Tpo 1 0.07 1.16 0.15
54 INT78367 Positive_regulation of Negative_regulation of Dio1 1 0.50 0.46 0.14
55 INT134732 Protein_catabolism of DUOX1 1 0.00 0 0.13
56 INT242865 Binding of HFE 7 0.42 6.01 0.12
57 INT183042 Localization of HFE 2 0.56 1.35 0.12
58 INT95761 Negative_regulation of DIO3 1 0.25 0.52 0.1
59 INT335654 Negative_regulation of Gene_expression of DIO2 1 0.17 0.72 0.1
60 INT307408 Gene_expression of DUOX2 1 0.23 1.38 0.08
61 INT100859 Negative_regulation of Regulation of TPO 1 0.38 0.38 0.07
62 INT89933 Negative_regulation of Tg 2 0.04 1.78 0.06
63 INT39690 Positive_regulation of DIO3 2 0.02 0.48 0.06
64 INT286191 Negative_regulation of Tpo 1 0.06 1.57 0.05
65 INT183072 Positive_regulation of Localization of HFE 1 0.05 0.2 0.03
66 INT242866 Regulation of HFE 2 0.39 1.84 0
67 INT184567 Binding of Tg 1 0.07 0.27 0
68 INT184569 Regulation of Positive_regulation of Tg 1 0.09 0 0
69 INT293569 Positive_regulation of Gene_expression of TPO 1 0.05 0.37 0
70 INT319778 Regulation of Localization of Dio1 1 0.24 0.29 0
71 INT286195 Regulation of Tpo 1 0.08 0.34 0
72 INT276140 Regulation of Negative_regulation of DIO2 1 0.34 0.07 0
73 INT286207 Positive_regulation of Tpo 1 0.07 0.78 0
74 INT184570 Transcription of Tg 1 0.12 0.08 0
75 INT319783 Positive_regulation of Localization of Dio1 1 0.26 0.24 0
76 INT184568 Regulation of Binding of Tg 1 0.08 0.15 0
77 INT262673 Localization of Tg 1 0.13 0 0
78 INT307412 Binding of DUOX2 1 0.14 0.96 0
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