GO:0042448

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Name progesterone metabolic process
Categary Process
Go Slim No
Go Link GO:0042448
Unique Molecular Interactions 71
Total Molecular Interactions 88
Total Single Events 1649
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for progesterone metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for progesterone metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT29599 Binding of Cyp21a1 and Adarb1 1 0.01 0 1.38
2 INT117604 AKR1C1 Negative_regulation of Positive_regulation of Mpo 1 0.00 1.45 0.78
3 INT333476 IL12B Positive_regulation of Localization of AFP 1 0.03 0.26 0.57
4 INT116926 Cpox Regulation of AKR1C3 1 0.01 0.28 0.45
5 INT151637 Binding of Cyp21a1 and Ear11 1 0.01 0 0.44
6 INT61660 Binding of CHAT and CYP21A2 1 0.00 0 0.4
7 INT167946 Binding of SRC and Stat5b 1 0.28 0 0.38
8 INT187064 ARSD Negative_regulation of CYP19A1 1 0.22 0.7 0.35
9 INT122169 AKR1C3 Regulation of PPARG 1 0.45 0.26 0.33
10 INT175330 IL6 Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.97 0.32
11 INT222299 Binding of CYP19A1 and AIS 2 0.25 1.65 0.31
12 INT122168 AKR1C1 Regulation of PPARG 1 0.12 0.25 0.31
13 INT156087 Binding of AKR1C3 and Akr1c1 1 0.05 0.31 0.3
14 INT156083 Binding of AKR1C2 and AKR1C3 1 0.05 0.31 0.3
15 INT156084 Binding of PTGS2 and AKR1C3 1 0.02 0.31 0.3
16 INT156082 Binding of PTGS1 and AKR1C3 1 0.01 0.31 0.3
17 INT134927 CYP19A1 Positive_regulation of Gene_expression of MME 1 0.30 1.04 0.28
18 INT134930 MME Positive_regulation of Gene_expression of CYP19A1 1 0.30 1.04 0.28
19 INT199970 CYP19A1 Positive_regulation of Gene_expression of ESR1 1 0.06 0.72 0.25
20 INT145140 Negative_regulation of CPOX Negative_regulation of Gene_expression of CYP19A1 1 0.13 0.47 0.2
21 INT90772 Binding of AKR1C4 and AKR1C1 1 0.39 0.08 0.2
22 INT198382 Binding of AR and SRD5A1 2 0.06 0.84 0.17
23 INT299725 AFP Positive_regulation of Positive_regulation of ACPP 1 0.00 0.78 0.17
24 INT116124 Binding of AFP and HCC 2 0.20 1.72 0.15
25 INT355867 Binding of Afp and HCC 1 0.01 2.25 0.14
26 INT156056 AKR1C1 Negative_regulation of UMOD 1 0.03 0.41 0.1
27 INT184089 Gh Positive_regulation of Stat5b 1 0.13 1.3 0.1
28 INT220394 MRXS5 Positive_regulation of Gene_expression of CYP19A1 1 0.00 0.89 0.09
29 INT41514 Oxt Regulation of AFP 1 0.16 0.09 0.09
30 INT285070 CCL16 Positive_regulation of Gene_expression of CYP19A1 1 0.02 0.69 0.09
31 INT220412 Cpox Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.9 0.09
32 INT261262 AIS Negative_regulation of Cyp19a1 1 0.01 0.2 0.08
33 INT213933 AR Negative_regulation of Cyp19a1 1 0.07 0.79 0.07
34 INT212071 Eno2 Regulation of Localization of Afp 1 0.01 0.52 0.07
35 INT212079 SYP Regulation of Localization of Afp 1 0.10 0.52 0.07
36 INT212077 CHGA Regulation of Localization of Afp 1 0.10 0.52 0.07
37 INT212070 ENO2 Regulation of Localization of AFP 1 0.49 0.52 0.07
38 INT212076 ENO2 Regulation of Localization of Afp 1 0.10 0.52 0.07
39 INT212067 CHGA Regulation of Localization of AFP 1 0.49 0.52 0.07
40 INT212081 Eno2 Regulation of Localization of AFP 1 0.03 0.52 0.07
41 INT212062 SYP Regulation of Localization of AFP 1 0.49 0.52 0.07
42 INT323042 Binding of CYP21A2 and HLA-DOA 1 0.04 1.49 0.06
43 INT187732 Binding of CYP19A1 and Cyp11a1 1 0.01 0.68 0.04
44 INT213262 IL6 Positive_regulation of CYP19A1 1 0.11 1.63 0.03
45 INT187676 Binding of CYP19A1 and SHBG 1 0.01 0.63 0.03
46 INT133804 Binding of CYP2B6 and CYP19A1 3 0.09 2.26 0
47 INT176564 Binding of Cyp17a1 and Cyp19a1 1 0.03 0.33 0
48 INT350120 FSHR Regulation of CYP19A1 1 0.01 3.02 0
49 INT242176 AIS Negative_regulation of CYP19A1 1 0.07 0.69 0
50 INT187674 FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.24 0 0
51 INT20325 Binding of CYP2D6 and CYP21A2 1 0.00 0 0
52 INT20326 Binding of CYP1A2 and CYP21A2 1 0.01 0 0
53 INT242178 CYP19A1 Regulation of Cyp11a1 1 0.01 0.35 0
54 INT255384 Binding of AKR1C2 and DSG1 1 0.01 1.54 0
55 INT176569 Binding of FSHR and Cyp19a1 1 0.04 0.06 0
56 INT355864 EXT1 Positive_regulation of Positive_regulation of Afp 1 0.05 0.93 0
57 INT242179 Cyp11a1 Regulation of CYP19A1 1 0.01 0.7 0
58 INT187670 Gene_expression of FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.16 0 0
59 INT20321 Binding of CYP2E1 and CYP21A2 1 0.00 0 0
60 INT277622 Esr1 Positive_regulation of Gene_expression of Cyp19a1 1 0.03 1.37 0
61 INT355866 Binding of EXT1 and Afp 1 0.04 3.56 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for progesterone metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in progesterone metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21
2 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26
3 INT99495 Gene_expression of SRD5A1 14 0.77 5 9.21
4 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19
5 INT10597 Gene_expression of Cyp19a1 27 0.78 7.48 9.11
6 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34
7 INT8669 Positive_regulation of Afp 66 0.70 58.21 7.67
8 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28
9 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13
10 INT135760 Regulation of Gene_expression of Cyp19a1 2 0.62 1.15 5.81
11 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37
12 INT745 Gene_expression of Afp 65 0.78 52.89 4.24
13 INT108086 Negative_regulation of AKR1C3 17 0.58 7.7 3.99
14 INT99889 Transcription of SRD5A1 5 0.71 1.45 3.74
15 INT10824 Negative_regulation of Cyp19a1 38 0.57 25.18 3.56
16 INT8477 Negative_regulation of AFP 35 0.58 31.52 3.1
17 INT116376 Transcription of Cyp19a1 2 0.40 0.74 3.04
18 INT133809 Negative_regulation of Gene_expression of CYP19A1 9 0.43 7.67 2.99
19 INT113277 Positive_regulation of Gene_expression of CYP19A1 13 0.69 10.23 2.97
20 INT16616 Negative_regulation of SRD5A1 44 0.57 34.81 2.96
21 INT8670 Negative_regulation of Afp 27 0.58 19.85 2.87
22 INT78146 Gene_expression of AKR1C3 24 0.77 5.71 2.77
23 INT60339 Gene_expression of CYP21A2 8 0.66 4.04 2.77
24 INT71048 Transcription of CYP19A1 11 0.72 8.74 2.24
25 INT111113 Binding of CYP19A1 15 0.36 9.17 2.12
26 INT342803 Positive_regulation of Transcription of Cyp19a1 1 0.30 0.33 2.08
27 INT342815 Positive_regulation of Transcription of SRD5A1 1 0.49 0.33 2.04
28 INT81347 Regulation of Cyp19a1 7 0.40 2.1 1.94
29 INT29598 Binding of Cyp21a1 5 0.31 0.09 1.71
30 INT10596 Positive_regulation of Cyp19a1 10 0.42 2.08 1.62
31 INT14971 Regulation of Afp 12 0.44 11.35 1.48
32 INT127889 Regulation of Gene_expression of CYP19A1 11 0.62 6.7 1.41
33 INT10576 Gene_expression of Cyp21a1 7 0.44 1.62 1.32
34 INT160606 Localization of AFP 6 0.74 3.39 1.29
35 INT198387 Regulation of SRD5A1 2 0.60 1.29 1.26
36 INT122171 Negative_regulation of AKR1C1 5 0.59 1.92 1.22
37 INT10574 Positive_regulation of Cyp21a1 5 0.44 0.18 1.09
38 INT24297 Regulation of CYP21A2 3 0.05 1.29 1.09
39 INT71349 Negative_regulation of Cyp21a1 3 0.42 1.7 1.04
40 INT154493 Regulation of Gene_expression of SRD5A1 3 0.45 0.58 1.03
41 INT217950 Positive_regulation of Negative_regulation of CYP21A2 2 0.03 1.34 0.97
42 INT331007 Negative_regulation of Gene_expression of CYP21A2 1 0.02 1.34 0.97
43 INT39357 Binding of Afp 5 0.48 3.58 0.85
44 INT10571 Regulation of Cyp21a1 3 0.26 0 0.85
45 INT167938 Positive_regulation of Phosphorylation of Stat5b 1 0.33 0 0.85
46 INT167942 Binding of Stat5b 1 0.26 0 0.82
47 INT66061 Positive_regulation of Gene_expression of AFP 6 0.70 8.67 0.81
48 INT79344 Binding of Cyp19a1 4 0.33 0.61 0.8
49 INT108085 Positive_regulation of Gene_expression of AKR1C3 2 0.53 0.58 0.75
50 INT138040 Regulation of Gene_expression of CYP21A2 1 0.00 0.58 0.72
51 INT161339 Localization of Cyp19a1 1 0.73 1.32 0.71
52 INT41928 Binding of AFP 9 0.36 7.85 0.7
53 INT14973 Regulation of Gene_expression of AFP 3 0.44 4.16 0.69
54 INT156085 Negative_regulation of AKR1C2 3 0.54 0.79 0.66
55 INT10573 Regulation of Gene_expression of Cyp21a1 1 0.01 0 0.64
56 INT10577 Transcription of Cyp21a1 1 0.01 0 0.64
57 INT115276 Gene_expression of AKR1C1 11 0.77 4.65 0.63
58 INT42098 Regulation of Akr1c1 1 0.37 0 0.6
59 INT171105 Positive_regulation of Positive_regulation of CYP19A1 5 0.39 4.02 0.58
60 INT78999 Binding of AKR1C1 3 0.36 1.75 0.58
61 INT156077 Negative_regulation of Akr1c1 1 0.09 0.74 0.57
62 INT116925 Binding of AKR1C3 2 0.36 0.75 0.56
63 INT353896 Negative_regulation of Phosphorylation of Cyp19a1 1 0.22 0.47 0.55
64 INT353893 Phosphorylation of Cyp19a1 1 0.31 0.46 0.55
65 INT15046 Positive_regulation of Gene_expression of Afp 6 0.46 5.95 0.52
66 INT24029 Regulation of AFP 7 0.44 6.45 0.51
67 INT97664 Binding of AKR1C2 1 0.48 0 0.51
68 INT97663 Localization of AKR1C2 2 0.71 0.43 0.5
69 INT342811 Positive_regulation of Gene_expression of SRD5A1 1 0.45 0.22 0.5
70 INT71046 Localization of CYP19A1 2 0.78 1.38 0.48
71 INT130391 Positive_regulation of AKR1C3 4 0.50 1.7 0.47
72 INT14972 Regulation of Gene_expression of Afp 2 0.45 1.1 0.47
73 INT187717 Regulation of Negative_regulation of CYP19A1 11 0.42 2.85 0.45
74 INT127890 Positive_regulation of Negative_regulation of CYP19A1 6 0.50 1.41 0.45
75 INT105408 Negative_regulation of Gene_expression of AKR1C3 1 0.23 0.56 0.45
76 INT84915 Negative_regulation of Gene_expression of Cyp19a1 2 0.15 1.29 0.42
77 INT167941 Phosphorylation of Stat5b 1 0.58 0 0.42
78 INT122170 Regulation of AKR1C1 1 0.12 0.22 0.42
79 INT181122 Positive_regulation of Gene_expression of Cyp19a1 1 0.02 0.68 0.36
80 INT10569 Regulation of Transcription of Cyp21a1 1 0.01 0 0.35
81 INT209323 Positive_regulation of Transcription of CYP19A1 5 0.32 4.22 0.33
82 INT102992 Regulation of Negative_regulation of SRD5A1 4 0.60 3.59 0.29
83 INT336270 Localization of AKR1C1 1 0.06 1.56 0.29
84 INT168052 Gene_expression of Akr1c1 1 0.40 0 0.28
85 INT154494 Transcription of AKR1C1 4 0.72 0.99 0.27
86 INT44058 Localization of CYP21A2 2 0.74 0.73 0.27
87 INT156076 Negative_regulation of Localization of Akr1c1 1 0.09 0.43 0.27
88 INT156086 Negative_regulation of Localization of AKR1C2 1 0.10 0.43 0.27
89 INT156078 Localization of Akr1c1 1 0.15 0.43 0.27
90 INT126794 Binding of SRD5A1 2 0.36 3.26 0.22
91 INT8478 Negative_regulation of Gene_expression of AFP 3 0.42 2.37 0.19
92 INT93748 Regulation of Positive_regulation of Cyp21a1 1 0.03 0 0.19
93 INT355487 Positive_regulation of Regulation of Afp 1 0.04 1.19 0.19
94 INT175360 Regulation of Transcription of CYP19A1 1 0.04 1 0.19
95 INT167940 Regulation of Stat5b 1 0.43 0 0.19
96 INT50950 Localization of Afp 9 0.50 5.04 0.18
97 INT52943 Positive_regulation of Positive_regulation of Afp 1 0.31 1.11 0.17
98 INT1275 Gene_expression of AKR1C2 1 0.75 2.92 0.16
99 INT153084 Positive_regulation of Gene_expression of AKR1C1 4 0.50 1.56 0.14
100 INT78144 Transcription of AKR1C3 4 0.72 1.21 0.13
101 INT146889 Positive_regulation of CYP21A2 1 0.39 0 0.12
102 INT236875 Localization of SRD5A1 2 0.73 0.8 0.11
103 INT51370 Negative_regulation of Gene_expression of Afp 1 0.18 0.16 0.09
104 INT46801 Negative_regulation of Binding of Cyp21a1 1 0.35 0.09 0.09
105 INT143828 Regulation of AKR1C3 1 0.06 1.32 0.07
106 INT177877 Positive_regulation of AKR1C1 3 0.50 1.13 0.06
107 INT236876 Negative_regulation of Localization of SRD5A1 1 0.41 0.81 0.06
108 INT31482 Regulation of Binding of Cyp21a1 1 0.23 0 0.06
109 INT144158 Negative_regulation of Positive_regulation of AFP 1 0.42 1.66 0.06
110 INT187718 Negative_regulation of Positive_regulation of CYP19A1 1 0.33 0.61 0.05
111 INT178538 Transcription of AKR1C2 3 0.67 1.17 0.03
112 INT187720 Negative_regulation of Negative_regulation of CYP19A1 5 0.34 0.99 0
113 INT178534 Positive_regulation of SRD5A1 2 0.44 1.23 0
114 INT236869 Negative_regulation of Negative_regulation of SRD5A1 2 0.41 2.68 0
115 INT187725 Positive_regulation of Localization of CYP19A1 1 0.39 0.23 0
116 INT323048 Binding of CYP21A2 1 0.37 1.9 0
117 INT213932 Negative_regulation of Negative_regulation of Cyp19a1 1 0.31 0.7 0
118 INT194353 Negative_regulation of Binding of Cyp19a1 1 0.15 0 0
119 INT145141 Negative_regulation of Transcription of CYP19A1 1 0.59 0.3 0
120 INT178540 Regulation of Gene_expression of AKR1C3 1 0.59 0.32 0
121 INT207723 Positive_regulation of Transcription of AKR1C1 1 0.33 0.68 0
122 INT178543 Regulation of Gene_expression of AKR1C1 1 0.43 0.32 0
123 INT187719 Negative_regulation of Localization of CYP19A1 1 0.33 0.78 0
124 INT222306 Negative_regulation of Binding of CYP19A1 1 0.20 1.04 0
125 INT353174 Gene_expression of Stat5b 1 0.48 0 0
126 INT207758 Positive_regulation of AKR1C2 1 0.52 0.67 0
127 INT178546 Negative_regulation of Gene_expression of AKR1C2 1 0.42 0.41 0
128 INT178533 Negative_regulation of Gene_expression of AKR1C1 1 0.41 0.61 0
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