GO:0042535

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Name positive regulation of tumor necrosis factor biosynthetic process
Categary Process
Go Slim No
Go Link GO:0042535
Unique Molecular Interactions 722
Total Molecular Interactions 1155
Total Single Events 7198
Pain Genes Associated 24

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of tumor necrosis factor biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of tumor necrosis factor biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
2 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
3 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
4 INT91649 Binding of Lbp and SPECC1 1 0.12 2.88 2.78
5 INT212505 Binding of pr and Lbp 1 0.01 4.26 2.62
6 INT67905 Binding of Spn and Fosl1 1 0.24 2.1 2.54
7 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
8 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
9 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
10 INT161224 Ccl2 Positive_regulation of Ccr2 1 0.52 2.09 1.88
11 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
12 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
13 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
14 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
15 INT253863 Binding of LBP and PNP 1 0.13 1.5 1.5
16 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
17 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
18 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
19 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
20 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
21 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
22 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
23 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
24 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
25 INT167426 Tlr4 Positive_regulation of Localization of Gpt 1 0.25 1.26 1.1
26 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
27 INT130657 Negative_regulation of Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
28 INT150794 ZNF398 Positive_regulation of Localization of THBS1 1 0.09 1.02 1.07
29 INT150789 THBS3 Negative_regulation of THBS1 1 0.18 1.01 1.06
30 INT181434 Binding of Ccr2 and Ccl2 1 0.27 6.06 1.04
31 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03
32 INT174910 Binding of LBP and IFIH1 1 0.04 1.01 1.01
33 INT317584 Binding of Lbp and Pgp 1 0.24 1.08 0.99
34 INT167173 Binding of Ccl2 and Ccr2 2 0.30 1.15 0.98
35 INT145163 Tlr4 Positive_regulation of Localization of Nsfl1c 1 0.02 0.43 0.94
36 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
37 INT336017 Vip Regulation of Tlr4 1 0.22 1.23 0.93
38 INT306327 Binding of Ly96 and Tlr4 1 0.10 1.83 0.91
39 INT343909 IgG Positive_regulation of Gene_expression of TLR4 1 0.04 3.49 0.91
40 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9
41 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89
42 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
43 INT168281 Tlr4 Positive_regulation of Phosphorylation of Mapk4 1 0.06 1.05 0.89
44 INT244323 Csf2 Positive_regulation of Gene_expression of Tlr4 1 0.23 1.93 0.85
45 INT343829 TLR1 Positive_regulation of TBCE 1 0.03 0.96 0.85
46 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83
47 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
48 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79
49 INT223753 Tlr4 Positive_regulation of Gene_expression of Il10 4 0.32 1.93 0.78
50 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
51 INT339495 Tlr4 Positive_regulation of Eif2ak2 1 0.21 0.58 0.77
52 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76
53 INT284306 Tlr4 Positive_regulation of Adrb3 1 0.00 1.19 0.74
54 INT317585 Binding of Lbp and Ppap2b 1 0.03 0.78 0.72
55 INT222432 Binding of Tlr4 and Cd14 1 0.02 0.74 0.71
56 INT89936 Tlr4 Positive_regulation of Il6 3 0.49 0.95 0.7
57 INT215098 Tlr4 Positive_regulation of Localization of Il6 3 0.18 1.18 0.69
58 INT280951 Tlr4 Positive_regulation of Localization of S100a8 1 0.01 1.09 0.69
59 INT215093 Tlr4 Positive_regulation of Localization of Hmgb1 1 0.32 2.9 0.68
60 INT306020 Binding of LBP and Tlr4 1 0.13 0.34 0.66
61 INT120144 Negative_regulation of Tlr4 Positive_regulation of Tnf 1 0.18 0.91 0.66
62 INT343851 Positive_regulation of Binding of IRF6 and TLR4 1 0.07 1.96 0.66
63 INT244320 Tlr4 Positive_regulation of Aliq1 3 0.04 4.51 0.64
64 INT281130 Ccl2 Regulation of Gene_expression of Ccr2 1 0.04 1.09 0.64
65 INT281134 Ccl2 Positive_regulation of Gene_expression of Ccr2 1 0.08 1.09 0.64
66 INT281122 Ccl2 Regulation of Ccr2 1 0.04 1.09 0.63
67 INT339393 Tlr4 Positive_regulation of Nfkb1 1 0.24 2.06 0.61
68 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6
69 INT276603 Il10 Positive_regulation of Gene_expression of Tlr4 1 0.12 0.49 0.6
70 INT140264 Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
71 INT140263 Negative_regulation of Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
72 INT275552 Tlr4 Positive_regulation of Gene_expression of Il1 1 0.00 1.28 0.59
73 INT212813 Tlr4 Positive_regulation of Nos2 3 0.34 0.89 0.57
74 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
75 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 0.01 1.17 0.57
76 INT306330 Cd14 Positive_regulation of Gene_expression of Tlr4 1 0.48 0.54 0.57
77 INT146871 Tlr4 Positive_regulation of Gene_expression of ROS1 2 0.00 1.16 0.56
78 INT81303 Tlr4 Positive_regulation of Gene_expression of Hmox1 1 0.03 0.55 0.56
79 INT94745 Tlr4 Positive_regulation of Transcription of Il1b 1 0.15 0.48 0.56
80 INT175323 Tlr4 Positive_regulation of Gene_expression of TLR2 1 0.02 0.31 0.56
81 INT222252 Positive_regulation of Binding of Ccr2 and Fig4 1 0.16 0.67 0.55
82 INT222246 Binding of Ccr2 and Tcf21 1 0.29 0.67 0.55
83 INT222249 Positive_regulation of Binding of Ccr2 and Tcf21 1 0.39 0.67 0.55
84 INT120143 Tlr4 Negative_regulation of Gene_expression of Tnf 1 0.18 0.76 0.55
85 INT222245 Binding of Ccr2 and Fig4 1 0.12 0.67 0.55
86 INT243056 Binding of LBP and Tlr4 1 0.00 1.11 0.55
87 INT310767 Tlr4 Regulation of Gene_expression of S100a8 1 0.02 0.7 0.54
88 INT210934 Gene_expression of Tlr4 Negative_regulation of Ccl2 1 0.47 0.69 0.54
89 INT354367 Binding of FGFR1 and Tlr4 1 0.01 1.23 0.53
90 INT150791 THBS1 Negative_regulation of TIMP2 1 0.17 0.5 0.52
91 INT150796 ZNF398 Positive_regulation of THBS1 1 0.06 0.5 0.52
92 INT150785 THBS1 Negative_regulation of MMP2 1 0.10 0.5 0.52
93 INT179503 Cd14 Regulation of Positive_regulation of Tlr4 1 0.38 0.58 0.52
94 INT343838 EDA Positive_regulation of TLR4 1 0.11 0.87 0.51
95 INT285911 Binding of TLR4 and Cd14 1 0.05 1.13 0.51
96 INT324523 Tlr4 Regulation of Gene_expression of PGE 1 0.23 1.98 0.51
97 INT179507 Tlr4 Positive_regulation of Tlr2 2 0.17 1.07 0.49
98 INT306019 Binding of Tlr4 and LY96 1 0.06 0.91 0.49
99 INT254119 Binding of Bcl2a1a and Tlr4 1 0.01 1.34 0.49
100 INT210160 Binding of TNFRSF8 and TXN 1 0.47 4.16 0.48
101 INT209046 Slc11a1 Positive_regulation of Regulation of Tlr4 1 0.07 0.09 0.48
102 INT244319 Csf2 Positive_regulation of Positive_regulation of Tlr4 1 0.23 1.03 0.48
103 INT322264 Binding of MPZ and TLR4 1 0.18 1.68 0.47
104 INT233527 Tlr4 Positive_regulation of ADORA1 1 0.00 0.45 0.47
105 INT233503 Tlr4 Positive_regulation of Adora2b 1 0.06 0.45 0.47
106 INT284300 Tlr4 Positive_regulation of Gene_expression of Mir155 1 0.18 0.91 0.47
107 INT246938 Binding of Tlr4 and Tlr2 3 0.39 2.88 0.46
108 INT207141 Tlr4 Positive_regulation of Positive_regulation of Pawr 1 0.05 0.79 0.46
109 INT233508 Tlr4 Regulation of Gene_expression of Gpr18 1 0.04 0.45 0.46
110 INT310769 Pam Regulation of Tlr4 1 0.01 0.69 0.46
111 INT349853 Binding of Hspb1 and Jun 1 0.14 2.3 0.45
112 INT281126 Binding of Ccr2 and Cxcr4 1 0.30 0.32 0.44
113 INT69163 Tlr4 Positive_regulation of Ptgs1 1 0.02 0.08 0.44
114 INT230461 Binding of TLR1 and TLR2 3 0.33 2.06 0.43
115 INT212810 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.03 0.74 0.43
116 INT247599 Tlr4 Positive_regulation of Gene_expression of App 1 0.17 0.39 0.42
117 INT181448 Eae1 Positive_regulation of Gene_expression of Ccr2 1 0.04 4.98 0.42
118 INT308696 Binding of Tlr4 and Tlr4 1 0.00 0.34 0.42
119 INT336926 Mir341 Regulation of Tlr4 1 0.02 1.57 0.41
120 INT348790 Binding of MYD88 and Tlr4 1 0.35 1.84 0.4
121 INT238384 Tlr4 Positive_regulation of Prkca 1 0.06 0.81 0.4
122 INT295478 IRF6 Positive_regulation of Positive_regulation of TLR4 2 0.20 0.78 0.39
123 INT222418 Tlr4 Positive_regulation of Gene_expression of Il1a 1 0.00 0.31 0.39
124 INT152238 Mapk14 Positive_regulation of Localization of Tlr4 1 0.29 0.13 0.39
125 INT152237 Mapk1 Positive_regulation of Localization of Tlr4 1 0.33 0.13 0.39
126 INT81300 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.02 0.38 0.39
127 INT260744 Binding of Ecm1 and Tlr2 1 0.00 0.45 0.39
128 INT310697 Tlr4 Positive_regulation of Gene_expression of Ptger2 2 0.03 1.34 0.38
129 INT339504 Binding of Irak1 and Tlr4 1 0.08 0.12 0.38
130 INT204893 Regulation of Tlr4 Positive_regulation of gr 1 0.11 0.9 0.38
131 INT260746 Binding of TLR4 and Ecm1 1 0.02 0.44 0.38
132 INT147969 Binding of Ly86 and Tlr4 1 0.30 0.37 0.38
133 INT260747 Binding of TLR4 and Tlr2 1 0.05 0.44 0.38
134 INT215275 Tlr4 Positive_regulation of Gene_expression of Ros1 1 0.01 1.37 0.38
135 INT339511 Binding of Tlr4 and Traf6 1 0.05 0.12 0.38
136 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38
137 INT188560 Negative_regulation of Binding of IRF6 and TLR4 1 0.04 0.58 0.38
138 INT204905 Tlr4 Positive_regulation of gr 1 0.18 0.9 0.38
139 INT130930 Egr1 Negative_regulation of Positive_regulation of Thbs1 1 0.58 0.64 0.38
140 INT324821 Tlr4 Positive_regulation of Gene_expression of Maob 1 0.07 0.44 0.37
141 INT324813 Tlr4 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
142 INT100091 Tlr4 Regulation of Localization of Tnf 1 0.01 0.42 0.37
143 INT324823 Tlr4 Positive_regulation of Gene_expression of Hmgb1 1 0.21 0.51 0.37
144 INT324818 Hmgb1 Positive_regulation of Gene_expression of Tlr4 1 0.21 0.51 0.37
145 INT163909 CCL2 Positive_regulation of Positive_regulation of Ccr2 1 0.05 0.19 0.36
146 INT110135 Tlr4 Regulation of Localization of Gnrh1 1 0.01 0.2 0.36
147 INT324808 Tlr4 Positive_regulation of Bad 1 0.02 0.43 0.36
148 INT337304 PTAFR Positive_regulation of Gene_expression of TLR4 1 0.62 1.99 0.36
149 INT188563 TLR4 Positive_regulation of Gene_expression of PRF1 1 0.03 0.78 0.36
150 INT174699 Binding of Tlr2 and Tlr3 3 0.14 0.66 0.35
151 INT118743 Tlr4 Positive_regulation of Itgam 1 0.39 0.41 0.35
152 INT163906 CCL2 Positive_regulation of CCR2 1 0.18 0.2 0.35
153 INT110132 Tlr4 Regulation of Localization of LH 1 0.01 0.2 0.35
154 INT163908 CCL2 Positive_regulation of Ccr2 1 0.05 0.2 0.35
155 INT310765 Binding of Pam and Tlr2 1 0.01 0.57 0.35
156 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34
157 INT244324 Csf2 Positive_regulation of Tlr4 1 0.23 0.95 0.34
158 INT288200 Tlr2 Positive_regulation of Pik3r1 1 0.05 0.24 0.33
159 INT110134 Tlr4 Regulation of Regulation of Gnrh1 1 0.01 0.15 0.33
160 INT224691 Positive_regulation of Tlr4 Positive_regulation of Gene_expression of Il15 1 0.01 0.66 0.33
161 INT224681 Tlr2 Positive_regulation of Gene_expression of Il15 1 0.01 0.66 0.33
162 INT285715 Binding of Lbp and Set 1 0.06 0.33 0.33
163 INT285718 Binding of DNMT3B and Lbp 1 0.08 0.33 0.33
164 INT185385 Binding of TLR2 and TLR4 3 0.27 3.63 0.32
165 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
166 INT253766 Binding of Apex1 and Tlr4 1 0.03 0.53 0.32
167 INT295198 Tlr4 Positive_regulation of Gene_expression of Ptger2 1 0.01 0.15 0.32
168 INT322016 Binding of IL1B and TLR4 1 0.05 0.18 0.32
169 INT222441 Tlr4 Positive_regulation of Gene_expression of Tac1 1 0.00 0.39 0.32
170 INT276604 Tlr4 Positive_regulation of Gene_expression of Paf 1 0.22 0.37 0.31
171 INT352055 Negative_regulation of Binding of Spn and Gpr156 1 0.09 0.28 0.31
172 INT276605 Tlr4 Positive_regulation of Gene_expression of Mthfd1 1 0.06 0.37 0.31
173 INT288198 Binding of Tlr4 and Mapk14 1 0.01 0.63 0.31
174 INT185319 Il6 Positive_regulation of Gene_expression of Tlr4 1 0.11 0.36 0.31
175 INT185322 TNF Positive_regulation of Gene_expression of Tlr4 1 0.01 0.36 0.31
176 INT165921 Tlr4 Positive_regulation of Akt1 1 0.16 0.75 0.31
177 INT352054 Binding of Spn and Gpr156 1 0.08 0.28 0.31
178 INT165920 Negative_regulation of Tlr4 Positive_regulation of Akt1 1 0.13 0.75 0.31
179 INT306323 Tlr4 Positive_regulation of Ticam1 3 0.25 0.55 0.3
180 INT324832 Tlr4 Positive_regulation of IFNA1 1 0.05 0.46 0.3
181 INT229600 Tlr4 Positive_regulation of Il1a 1 0.00 0.41 0.3
182 INT223752 Tlr4 Positive_regulation of Il1 1 0.12 0.64 0.3
183 INT178342 Positive_regulation of Tlr4 Positive_regulation of Il6 1 0.13 0.25 0.3
184 INT306319 Cd14 Positive_regulation of Tlr4 1 0.48 0.29 0.3
185 INT168616 Tlr4 Negative_regulation of Localization of Tnf 1 0.33 0.44 0.3
186 INT354368 FGFR1 Positive_regulation of Tlr4 1 0.01 0.16 0.29
187 INT144862 Tlr4 Positive_regulation of PGE 2 0.13 0.35 0.28
188 INT215274 Tlr4 Positive_regulation of Ros1 2 0.02 1.48 0.28
189 INT310696 Tlr4 Positive_regulation of Positive_regulation of Cftr 1 0.16 0.74 0.28
190 INT337293 PTAFR Positive_regulation of Positive_regulation of TLR4 1 0.62 1.43 0.28
191 INT306107 Binding of CCL2 and Ccr2 1 0.06 0 0.28
192 INT339494 Eif2ak2 Positive_regulation of Tlr4 1 0.13 0.18 0.28
193 INT310255 Tlr4 Positive_regulation of Gene_expression of Cd86 2 0.18 0.06 0.27
194 INT276953 Positive_regulation of Tlr2 Positive_regulation of Phosphorylation of Stat3 1 0.38 0.93 0.27
195 INT343832 Positive_regulation of EDA Positive_regulation of TLR4 1 0.11 0.43 0.27
196 INT276979 Positive_regulation of Tlr2 Positive_regulation of Gene_expression of Stat3 1 0.38 0.93 0.27
197 INT295197 Tlr4 Positive_regulation of Ptger2 1 0.01 0.05 0.27
198 INT306018 Binding of Tlr4 and Tlr9 1 0.15 0.92 0.27
199 INT222428 Negative_regulation of Tlr4 Positive_regulation of Il6 1 0.01 0.26 0.27
200 INT222412 Cd14 Negative_regulation of Binding of Tlr4 1 0.02 0.26 0.27

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of tumor necrosis factor biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of tumor necrosis factor biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
2 INT1026 Binding of Lbp 207 0.48 150.96 119.16
3 INT9664 Binding of LBP 127 0.48 94.9 63.42
4 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
5 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
6 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16
7 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05
8 INT9372 Negative_regulation of Lbp 86 0.58 46.54 41.71
9 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
10 INT19759 Gene_expression of LBP 77 0.77 56.44 33.23
11 INT56809 Binding of Tlr4 184 0.48 106.02 31.18
12 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19
13 INT88046 Gene_expression of Ccr2 38 0.76 33.76 28.07
14 INT78251 Positive_regulation of LBP 38 0.69 39.98 26.73
15 INT9088 Negative_regulation of LBP 48 0.58 33.06 25.89
16 INT1030 Localization of Lbp 52 0.74 38.92 24.91
17 INT134651 Binding of TLR4 89 0.48 66.96 23.19
18 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26
19 INT78057 Localization of Tlr4 140 0.77 67.75 21.72
20 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37
21 INT102545 Gene_expression of Ccr2 42 0.78 61.43 19.81
22 INT52179 Regulation of Lbp 39 0.61 25.4 18.32
23 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33
24 INT151434 Positive_regulation of Ccr2 26 0.68 18.34 16.34
25 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49
26 INT107585 Gene_expression of CCR2 35 0.71 26.44 14.75
27 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6
28 INT151120 Negative_regulation of Tlr4 18 0.59 21.09 14.46
29 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62
30 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9
31 INT118742 Positive_regulation of Tlr4 32 0.69 27.55 11.09
32 INT57000 Localization of LBP 21 0.78 11.01 10.01
33 INT161222 Positive_regulation of Ccr2 13 0.55 13.77 8.89
34 INT32624 Regulation of LBP 15 0.60 11.48 8.71
35 INT146991 Positive_regulation of Gene_expression of Tlr4 21 0.69 20.76 8.69
36 INT88047 Positive_regulation of Gene_expression of Ccr2 15 0.60 10.5 8.63
37 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57
38 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41
39 INT73181 Gene_expression of Hspb1 24 0.78 15.84 7.31
40 INT102548 Negative_regulation of Ccr2 14 0.59 19.84 7.22
41 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14
42 INT71496 Positive_regulation of Hspb1 15 0.69 14.7 6.86
43 INT295467 Negative_regulation of Gene_expression of Tlr4 11 0.58 7.94 6.83
44 INT142596 Positive_regulation of Gene_expression of Tlr2 42 0.69 38.41 6.67
45 INT117142 Gene_expression of Thbs1 58 0.72 45.02 6.51
46 INT183910 Negative_regulation of Gene_expression of Lbp 10 0.35 9.78 6.15
47 INT97797 Localization of TLR4 18 0.77 13.78 6
48 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95
49 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69
50 INT168279 Regulation of Tlr4 17 0.54 8.97 5.5
51 INT142595 Negative_regulation of Tlr2 24 0.52 19.17 5.43
52 INT174688 Binding of Tlr2 45 0.42 36.65 5.25
53 INT145767 Negative_regulation of TLR4 18 0.43 11.03 5.25
54 INT145756 Gene_expression of Tlr2 23 0.74 20.77 5.18
55 INT1029 Positive_regulation of Gene_expression of Lbp 17 0.50 11.03 5.18
56 INT157622 Positive_regulation of Localization of Tlr4 34 0.48 22.63 5.09
57 INT11106 Gene_expression of Lbp 10 0.67 10.29 4.52
58 INT23317 Gene_expression of Spn 20 0.48 14.51 4.01
59 INT161221 Positive_regulation of Positive_regulation of Ccr2 3 0.50 4.55 3.98
60 INT186808 Transcription of TLR4 22 0.69 12.77 3.73
61 INT222241 Binding of Ccr2 5 0.42 4.09 3.71
62 INT133733 Positive_regulation of Localization of Lbp 6 0.43 9.19 3.61
63 INT143159 Regulation of Gene_expression of TLR4 28 0.62 15.08 3.54
64 INT11101 Regulation of Gene_expression of Lbp 6 0.61 5.43 3.49
65 INT11107 Binding of Lbp 12 0.42 4.42 3.41
66 INT281144 Regulation of Gene_expression of Ccr2 2 0.44 2.38 3.29
67 INT178711 Protein_catabolism of Tlr4 15 0.84 6.75 3.19
68 INT120067 Positive_regulation of Gene_expression of CCR2 10 0.46 5.13 3.02
69 INT145768 Regulation of TLR4 19 0.45 8.31 2.96
70 INT185315 Transcription of Tlr4 24 0.69 8.65 2.93
71 INT222237 Negative_regulation of Gene_expression of Ccr2 3 0.37 3.39 2.91
72 INT151436 Regulation of Ccr2 4 0.44 2.81 2.82
73 INT24068 Localization of Hspb1 6 0.78 6.11 2.75
74 INT222226 Negative_regulation of Ccr2 6 0.57 3.69 2.66
75 INT100086 Negative_regulation of Localization of Tlr4 15 0.37 5.92 2.47
76 INT137135 Gene_expression of THBS1 28 0.75 11.55 2.45
77 INT86426 Gene_expression of Hspb1 16 0.78 10.86 2.26
78 INT146504 Regulation of Ccr2 5 0.39 3.58 2.21
79 INT204775 Regulation of Tlr2 21 0.41 13.6 2.18
80 INT228889 Protein_catabolism of LBP 4 0.77 5.14 2.13
81 INT62331 Gene_expression of TNFRSF8 26 0.72 17.75 2.08
82 INT222609 Binding of Tlr4 8 0.43 4.03 1.98
83 INT130364 Positive_regulation of Thbs1 7 0.62 7.73 1.97
84 INT326816 Negative_regulation of Positive_regulation of Tlr4 2 0.59 3.96 1.95
85 INT222903 Gene_expression of TLR1 20 0.60 8.77 1.9
86 INT295469 Localization of Tlr4 3 0.75 2.22 1.88
87 INT60337 Positive_regulation of THBS1 8 0.46 4.69 1.83
88 INT166311 Positive_regulation of Gene_expression of LBP 7 0.49 4.15 1.81
89 INT203541 Regulation of Binding of LBP 1 0.39 1.96 1.79
90 INT181341 Binding of Ccr2 8 0.32 6.47 1.77
91 INT301954 Regulation of Negative_regulation of Tlr4 1 0.45 2.46 1.77
92 INT191862 Phosphorylation of Tlr4 17 0.79 6.89 1.74
93 INT228195 Negative_regulation of Gene_expression of Tlr2 14 0.40 12.17 1.74
94 INT65524 Regulation of Spn 8 0.21 3.82 1.7
95 INT92386 Gene_expression of Tnfrsf8 14 0.54 13.55 1.67
96 INT102550 Positive_regulation of Gene_expression of Ccr2 6 0.69 4.53 1.67
97 INT188584 Positive_regulation of Positive_regulation of TLR4 8 0.65 5.98 1.64
98 INT181373 Negative_regulation of Gene_expression of Ccr2 5 0.59 5.92 1.44
99 INT174683 Transcription of Tlr2 12 0.58 5.95 1.4
100 INT24069 Negative_regulation of Localization of Hspb1 3 0.14 3.93 1.3
101 INT221131 Localization of Tlr2 17 0.80 13.82 1.28
102 INT179497 Positive_regulation of Binding of Tlr4 12 0.50 6.49 1.27
103 INT288546 Regulation of Positive_regulation of THBS1 1 0.36 2.65 1.27
104 INT150805 Localization of THBS1 4 0.46 2.88 1.23
105 INT281139 Phosphorylation of Ccr2 2 0.79 1.2 1.18
106 INT281141 Positive_regulation of Phosphorylation of Ccr2 2 0.49 1.2 1.18
107 INT76303 Negative_regulation of Positive_regulation of Hspb1 1 0.42 0.49 1.17
108 INT190804 Positive_regulation of Tlr2 6 0.66 3.7 1.16
109 INT62959 Positive_regulation of CCR2 4 0.61 1.47 1.13
110 INT152225 Regulation of Positive_regulation of Tlr4 8 0.53 2.5 1.12
111 INT222235 Localization of Ccr2 7 0.73 5.32 1.12
112 INT23951 Negative_regulation of Spn 4 0.15 2.17 1.12
113 INT158242 Negative_regulation of Gene_expression of CCR2 3 0.37 2.13 1.12
114 INT180382 Gene_expression of Fcgr3 9 0.34 7.94 1.1
115 INT203729 Binding of Thbs1 1 0.27 3.83 1.1
116 INT130928 Positive_regulation of Gene_expression of Thbs1 7 0.62 5.62 1.08
117 INT151435 Negative_regulation of Positive_regulation of Ccr2 1 0.53 0.7 1.08
118 INT194657 Negative_regulation of CCR2 2 0.29 2.3 1.07
119 INT71498 Binding of Hspb1 7 0.42 7.38 1.05
120 INT71499 Localization of Hspb1 4 0.72 1.38 1.05
121 INT123962 Phosphorylation of Hspb1 8 0.82 2.08 1.04
122 INT99767 Regulation of THBS1 18 0.42 11.51 1.03
123 INT118738 Transcription of Tlr4 4 0.70 1.39 1
124 INT125892 Regulation of Hspb1 2 0.48 4.28 0.98
125 INT158064 Negative_regulation of Gene_expression of LBP 1 0.41 1.54 0.97
126 INT341431 Regulation of Positive_regulation of LBP 1 0.24 1.14 0.96
127 INT24067 Negative_regulation of Hspb1 1 0.11 0.67 0.95
128 INT288493 Positive_regulation of Gene_expression of Tlr2 4 0.66 4.38 0.94
129 INT73091 Binding of TNFRSF8 21 0.44 6.64 0.93
130 INT163869 Regulation of Binding of Lbp 3 0.45 1.07 0.93
131 INT160599 Regulation of Gene_expression of LBP 2 0.44 1.23 0.92
132 INT145760 Binding of Tlr2 5 0.46 3.59 0.89
133 INT295466 Positive_regulation of Regulation of Tlr4 2 0.44 1.33 0.89
134 INT61775 Negative_regulation of Binding of Lbp 1 0.42 0.88 0.88
135 INT168278 Positive_regulation of Phosphorylation of Tlr4 1 0.48 1.05 0.88
136 INT168277 Phosphorylation of Tlr4 1 0.78 1.05 0.88
137 INT220161 Negative_regulation of Binding of LBP 2 0.43 1.35 0.87
138 INT208243 Positive_regulation of Phosphorylation of Tlr4 5 0.31 3.74 0.86
139 INT68228 Positive_regulation of TNFRSF8 5 0.56 6.26 0.84
140 INT351306 Positive_regulation of Localization of LBP 1 0.47 1.82 0.82
141 INT154792 Regulation of Regulation of LBP 1 0.26 0.5 0.81
142 INT161223 Negative_regulation of Positive_regulation of Ccr2 1 0.43 0.83 0.81
143 INT154793 Regulation of Localization of LBP 1 0.44 0.5 0.81
144 INT188582 Positive_regulation of Transcription of TLR4 2 0.50 4.07 0.77
145 INT101084 Positive_regulation of Negative_regulation of Lbp 1 0.43 0.98 0.77
146 INT130363 Localization of Thbs1 9 0.75 4.99 0.76
147 INT148839 Regulation of Gene_expression of CCR2 2 0.26 1.78 0.76
148 INT295465 Regulation of Positive_regulation of Tlr4 2 0.39 1.28 0.75
149 INT151128 Positive_regulation of Negative_regulation of Tlr4 2 0.46 1 0.75
150 INT181711 Positive_regulation of Gene_expression of Fcgr3 2 0.08 1.67 0.74
151 INT224630 Positive_regulation of Positive_regulation of Tlr2 6 0.46 4.14 0.73
152 INT222239 Transcription of Ccr2 2 0.61 1.15 0.73
153 INT140708 Gene_expression of Tlr1 10 0.50 5.24 0.72
154 INT109983 Positive_regulation of Hspb1 7 0.66 6.66 0.72
155 INT254115 Negative_regulation of Phosphorylation of Tlr4 5 0.27 3.91 0.71
156 INT228188 Regulation of Gene_expression of Tlr2 5 0.45 6.96 0.71
157 INT23420 Positive_regulation of Spn 8 0.49 4.81 0.69
158 INT161529 Regulation of Gene_expression of Tlr4 3 0.45 2.7 0.69
159 INT136269 Transcription of CCR2 2 0.61 1.27 0.69
160 INT125890 Negative_regulation of Regulation of Hspb1 2 0.42 1.39 0.69
161 INT186800 Positive_regulation of Binding of TLR4 2 0.47 1.31 0.67
162 INT236785 Regulation of Positive_regulation of TLR4 1 0.32 1.28 0.66
163 INT234928 Phosphorylation of Hspb1 3 0.72 17.04 0.65
164 INT70216 Gene_expression of HSPB1 8 0.78 4.81 0.64
165 INT151891 Negative_regulation of Localization of Lbp 1 0.42 0.8 0.63
166 INT103939 Localization of Spn 1 0.52 1.85 0.6
167 INT252993 Negative_regulation of THBS1 8 0.55 6.93 0.59
168 INT56491 Positive_regulation of Tnfrsf8 4 0.12 3.38 0.59
169 INT117145 Negative_regulation of Gene_expression of Thbs1 11 0.43 5.67 0.57
170 INT236786 Positive_regulation of Localization of TLR4 2 0.45 1.89 0.57
171 INT237075 Gene_expression of Spn 5 0.42 5.18 0.56
172 INT204864 Negative_regulation of Negative_regulation of Tlr4 3 0.30 2.05 0.56
173 INT150808 Negative_regulation of Localization of THBS1 1 0.25 0.5 0.53
174 INT239551 Binding of CCR2 2 0.39 0 0.52
175 INT234597 Negative_regulation of Positive_regulation of Tlr2 2 0.30 2.25 0.52
176 INT222242 Positive_regulation of Transcription of Ccr2 1 0.44 0.66 0.52
177 INT123963 Positive_regulation of Gene_expression of Hspb1 7 0.70 3.39 0.51
178 INT234587 Positive_regulation of Transcription of Tlr2 3 0.36 1.84 0.51
179 INT246926 Negative_regulation of Transcription of Tlr4 3 0.41 1.78 0.49
180 INT236350 Transcription of Ccr2 2 0.72 3.59 0.49
181 INT242887 Positive_regulation of Gene_expression of TLR1 2 0.28 1.87 0.49
182 INT343888 Regulation of Regulation of TLR4 1 0.25 1.34 0.49
183 INT147606 Positive_regulation of TLR1 5 0.67 4.35 0.47
184 INT268576 Positive_regulation of Gene_expression of THBS1 2 0.64 2.26 0.47
185 INT202063 Regulation of Binding of TLR4 2 0.44 2.14 0.47
186 INT272877 Localization of Ccr2 2 0.75 1.68 0.46
187 INT152229 Positive_regulation of Regulation of Tlr4 2 0.40 0.29 0.46
188 INT281147 Regulation of Binding of Ccr2 1 0.39 0.86 0.46
189 INT16245 Binding of Spn 4 0.31 3.83 0.45
190 INT123960 Negative_regulation of Phosphorylation of Hspb1 2 0.43 0.48 0.42
191 INT203728 Regulation of Binding of Thbs1 1 0.33 2.76 0.42
192 INT203726 Regulation of Thbs1 2 0.33 1.41 0.41
193 INT288184 Binding of Tlr1 8 0.29 4.73 0.4
194 INT185313 Regulation of Transcription of Tlr4 3 0.20 0.49 0.39
195 INT230469 Binding of TLR1 6 0.40 1.81 0.38
196 INT178182 Negative_regulation of Binding of Tlr4 3 0.33 2.13 0.38
197 INT55437 Transcription of Lbp 2 0.60 0.48 0.38
198 INT210206 Positive_regulation of Gene_expression of TNFRSF8 1 0.64 2.13 0.38
199 INT123964 Transcription of Hspb1 2 0.53 0.67 0.37
200 INT163905 Positive_regulation of Positive_regulation of Ccr2 1 0.13 0.16 0.37
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