GO:0042554

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Name superoxide anion generation
Categary Process
Go Slim No
Go Link GO:0042554
Unique Molecular Interactions 433
Total Molecular Interactions 566
Total Single Events 4773
Pain Genes Associated 27

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for superoxide anion generation. They are ordered first by their pain relevance and then by number of times they were reported for superoxide anion generation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
2 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
3 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
4 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
5 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
6 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
7 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
8 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
9 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
10 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
11 INT130657 Negative_regulation of Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
12 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
13 INT130232 Binding of Cat and Sod1 1 0.35 0.3 0.98
14 INT130231 Positive_regulation of Binding of Cat and Sod1 1 0.46 0.3 0.98
15 INT119276 Negative_regulation of CYBB Negative_regulation of Positive_regulation of ROS1 1 0.09 1.18 0.97
16 INT119275 Negative_regulation of CYBB Negative_regulation of Gene_expression of ROS1 1 0.09 1.18 0.97
17 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
18 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
19 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
20 INT119274 CYBB Positive_regulation of ROS1 1 0.11 1.11 0.88
21 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
22 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
23 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
24 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
25 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
26 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
27 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
28 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
29 INT250959 Binding of HLA-B and SOD1 1 0.05 0.75 0.75
30 INT296097 Acsm3 Negative_regulation of SOD1 1 0.01 1.3 0.72
31 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
32 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
33 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
34 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
35 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
36 INT154766 Nox1 Positive_regulation of Localization of Prkce 1 0.47 0.45 0.66
37 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
38 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
39 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
40 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
41 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
42 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
43 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
44 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
45 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
46 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
47 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
48 INT274625 OPN1MW Positive_regulation of SOD1 1 0.19 0.29 0.5
49 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
50 INT330107 Racgap1 Regulation of Positive_regulation of Nox3 1 0.01 0.87 0.49
51 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
52 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
53 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
54 INT330108 Racgap1 Positive_regulation of Cybb 1 0.03 0.86 0.46
55 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
56 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
57 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
58 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
59 INT241914 SOD1 Positive_regulation of Ros1 1 0.00 0.76 0.44
60 INT342998 DUOX1 Positive_regulation of ROS1 1 0.23 0.25 0.43
61 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
62 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
63 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
64 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
65 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
66 INT250956 Positive_regulation of Binding of HLA-B and SOD1 1 0.07 0.38 0.38
67 INT173704 Binding of PCOS1 and Edn1 1 0.01 0.99 0.37
68 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
69 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
70 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
71 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
72 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
73 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
74 INT183780 INS Negative_regulation of Gene_expression of CYBB 1 0.02 1.74 0.34
75 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
76 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
77 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
78 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
79 INT147445 Pscs Positive_regulation of Gene_expression of CYBB 1 0.02 0.33 0.31
80 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
81 INT269064 Il6 Positive_regulation of Gene_expression of Cybb 1 0.75 0.79 0.31
82 INT71519 Edn1 Positive_regulation of Gene_expression of Adarb1 1 0.02 0.48 0.31
83 INT288911 AGT Positive_regulation of CYBB 3 0.07 2.96 0.28
84 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
85 INT351391 Binding of Sod2 and Gtf3a 1 0.00 0.18 0.27
86 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26
87 INT215273 Siglec1 Regulation of Ncf2 1 0.01 0.73 0.26
88 INT215289 Siglec1 Regulation of Cyba 1 0.01 0.74 0.26
89 INT215280 Siglec1 Regulation of Cybb 1 0.01 0.74 0.26
90 INT269060 Il6 Positive_regulation of Cybb 1 0.75 0.65 0.26
91 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
92 INT178095 EDN1 Positive_regulation of MMP3 1 0.04 0.88 0.24
93 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24
94 INT178085 EDN1 Positive_regulation of MMP7 1 0.06 0.89 0.24
95 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
96 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
97 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
98 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
99 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
100 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24
101 INT308670 Positive_regulation of CYBB Positive_regulation of Gene_expression of Ros1 1 0.00 0.68 0.23
102 INT182272 EDN1 Regulation of Gene_expression of MMP13 1 0.26 0.87 0.22
103 INT91686 Mb Positive_regulation of Edn1 1 0.03 0.29 0.22
104 INT182265 EDN1 Positive_regulation of NOS2 1 0.24 0.56 0.22
105 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21
106 INT239236 Prkca Regulation of CYBB 1 0.00 0.98 0.2
107 INT305508 Binding of Sod1 and Slc17a6 1 0.03 1.1 0.2
108 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
109 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
110 INT305511 Negative_regulation of Binding of Sod1 and Slc17a6 1 0.03 1.1 0.2
111 INT182258 EDN1 Positive_regulation of Positive_regulation of MMP1 1 0.15 0.47 0.19
112 INT199191 Negative_regulation of Sod2 Positive_regulation of Ros1 1 0.08 0 0.19
113 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19
114 INT28562 SOD1 Negative_regulation of Pacs1 1 0.03 2.63 0.19
115 INT219915 Edn1 Regulation of Positive_regulation of Trpv1 1 0.33 0 0.18
116 INT251492 Binding of HSPD1 and SOD1 1 0.02 1.45 0.18
117 INT140096 Gtf3a Positive_regulation of Gene_expression of Edn1 1 0.02 0.44 0.18
118 INT250949 Binding of KIR3DL2 and SOD1 1 0.24 0.55 0.18
119 INT171386 Edn1 Positive_regulation of Mapk1 1 0.05 0.13 0.18
120 INT60778 Edn1 Positive_regulation of EDNRA 1 0.00 0 0.18
121 INT355504 ANGPT2 Positive_regulation of CYBB 1 0.01 0.81 0.18
122 INT261579 Serpinc1 Negative_regulation of Gene_expression of CYBB 1 0.00 1.69 0.18
123 INT284450 Edn1 Positive_regulation of Gene_expression of MMP9 1 0.01 0.3 0.18
124 INT140094 Ifng Regulation of Gene_expression of Edn1 1 0.18 0.44 0.18
125 INT319173 TXN Positive_regulation of Gene_expression of SOD2 1 0.23 0.1 0.18
126 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
127 INT215270 Binding of Ncf1 and Ncf4 1 0.05 0.38 0.17
128 INT215269 Binding of Ncf2 and Ncf4 1 0.02 0.38 0.17
129 INT203759 Binding of EDN1 and TNF 1 0.16 0.71 0.16
130 INT324899 Edn1 Positive_regulation of Positive_regulation of Mmp9 1 0.10 0.66 0.16
131 INT94022 Positive_regulation of Binding of EDN1 and INSRR 1 0.06 0 0.16
132 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
133 INT94021 Binding of EDN1 and EDN2 1 0.26 0 0.16
134 INT94014 Positive_regulation of Binding of EDN1 and EDN3 1 0.36 0 0.16
135 INT324894 Edn1 Positive_regulation of Gene_expression of Mmp3 1 0.07 0.66 0.16
136 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15
137 INT21509 Agt Regulation of Edn1 1 0.53 0 0.15
138 INT328004 Binding of CYBB and Gnb5 1 0.00 1.13 0.15
139 INT182261 EDN1 Regulation of Gene_expression of MMP1 1 0.17 0.7 0.15
140 INT50500 Edn1 Positive_regulation of PTGS1 1 0.00 0.07 0.14
141 INT324898 Ece1 Regulation of Gene_expression of Edn1 1 0.17 0.8 0.14
142 INT161799 Positive_regulation of Binding of ECE1 and EDN1 1 0.07 0.68 0.14
143 INT252575 Rpe Negative_regulation of SOD1 1 0.03 2.39 0.14
144 INT240909 Hmgcr Regulation of Gene_expression of Sod1 1 0.03 0.53 0.14
145 INT269054 Positive_regulation of Il6 Positive_regulation of Cybb 1 0.54 0.3 0.14
146 INT332689 Binding of Edn1 and Ros1 1 0.08 0.71 0.14
147 INT269070 Regulation of Il6 Positive_regulation of Cybb 1 0.29 0.3 0.14
148 INT161798 Positive_regulation of Binding of EDN1 and ING1 1 0.06 0.66 0.13
149 INT161800 Binding of EDN1 and ING1 1 0.05 0.65 0.13
150 INT178083 EDN1 Positive_regulation of Gene_expression of VEGFA 1 0.09 1.8 0.13
151 INT206065 EDN1 Positive_regulation of IL6 1 0.03 0.47 0.12
152 INT178101 EDN1 Negative_regulation of Phosphorylation of BCL2 1 0.03 1 0.12
153 INT77863 EDN1 Positive_regulation of POMC 1 0.50 0.34 0.12
154 INT232787 CYBB Positive_regulation of Positive_regulation of Hif1a 1 0.01 0.66 0.12
155 INT182273 EDN1 Regulation of Gene_expression of BAD 1 0.11 0.73 0.12
156 INT345290 AGT Positive_regulation of NOX1 1 0.00 1.11 0.12
157 INT215283 Tlr4 Positive_regulation of Localization of Ncf1 2 0.05 1.04 0.11
158 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11
159 INT325998 Negative_regulation of Cybb Negative_regulation of Gene_expression of Ros1 1 0.06 1.3 0.11
160 INT266900 Gene_expression of Sod2 Negative_regulation of Gene_expression of Sod1 1 0.11 0.41 0.11
161 INT20123 Gtf2e1 Negative_regulation of CYBB 1 0.00 0 0.1
162 INT182270 EDN1 Positive_regulation of Gene_expression of MMP1 1 0.18 0.55 0.1
163 INT181569 Binding of Edn1 and Mapk8 1 0.09 2.7 0.1
164 INT181570 Binding of Edn1 and Mapk1 1 0.13 2.72 0.1
165 INT165507 CRAT Negative_regulation of Gene_expression of CYBB 1 0.00 0.1 0.1
166 INT6674 Edn1 Positive_regulation of Gene_expression of FOS 1 0.08 0.19 0.1
167 INT139476 Edn1 Positive_regulation of Ednra 1 0.00 1.07 0.1
168 INT20122 Cyp2c22 Negative_regulation of CYBB 1 0.00 0 0.1
169 INT10904 Edn1 Regulation of Localization of Nppb 1 0.22 0.54 0.1
170 INT92956 Edn1 Regulation of Positive_regulation of Nos2 1 0.18 0.17 0.09
171 INT332688 Ros1 Positive_regulation of Binding of Edn1 1 0.10 0.57 0.09
172 INT42224 ABCA1 Positive_regulation of CYBB 1 0.01 0 0.09
173 INT230750 Crp Positive_regulation of Edn1 1 0.10 0.27 0.09
174 INT269069 Binding of Cyba and Cybb 1 0.18 0.18 0.09
175 INT92957 Edn1 Regulation of Gene_expression of Nos2 1 0.18 0.17 0.09
176 INT269056 Positive_regulation of Binding of Cyba and Cybb 1 0.24 0.18 0.09
177 INT174133 Binding of Igfals and Sod1 3 0.19 3 0.08
178 INT242257 Binding of EDN1 and ELF3 1 0.17 0.21 0.08
179 INT55502 NDUFC1 Regulation of Nox1 1 0.00 0 0.08
180 INT303337 Binding of SOD1 and Igfals 1 0.06 1.27 0.08
181 INT181584 Binding of EDNRB and Edn1 1 0.46 0.85 0.08
182 INT181583 Binding of Edn1 and Positive_regulation of NOS1 1 0.02 0.86 0.08
183 INT178100 Gene_expression of EDNRB Positive_regulation of EDN1 1 0.17 1.11 0.08
184 INT113369 Edn1 Regulation of Adarb1 1 0.02 0.14 0.08
185 INT178081 Negative_regulation of EDN1 Positive_regulation of HIF1A 1 0.04 1.18 0.08
186 INT346695 Negative_regulation of SOD1 Positive_regulation of Negative_regulation of Hist3h2a 1 0.00 0.41 0.08
187 INT249162 CYBB Regulation of CA2 1 0.17 0.31 0.08
188 INT178080 EDN1 Positive_regulation of HIF1A 1 0.05 1.05 0.08
189 INT249166 Phosphorylation of NCF1 Positive_regulation of Localization of GOPC 1 0.03 0.06 0.08
190 INT309390 Gene_expression of Sod2 Negative_regulation of Nos3 1 0.31 0.2 0.08
191 INT31986 NTS Positive_regulation of Binding of SOD1 1 0.16 0 0.08
192 INT201736 Nfkb1 Positive_regulation of Transcription of Sod2 1 0.01 0.93 0.08
193 INT302131 Negative_regulation of SOD2 Regulation of BAK1 1 0.09 1.22 0.07
194 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07
195 INT182269 EDN1 Positive_regulation of Localization of MMP1 1 0.17 0.31 0.07
196 INT192908 Edn1 Positive_regulation of Ednra 1 0.21 0.35 0.07
197 INT269063 Gene_expression of Il6 Positive_regulation of Cybb 1 0.47 0.33 0.07
198 INT242258 ELF3 Negative_regulation of EDN1 1 0.15 0.09 0.07
199 INT309941 Edn1 Positive_regulation of Tlr2 1 0.02 1.31 0.07
200 INT302128 SOD2 Regulation of BAK1 1 0.09 1.22 0.07

Single Events

The table below shows the top 100 pain related interactions that have been reported for superoxide anion generation. They are ordered first by their pain relevance and then by number of times they were reported in superoxide anion generation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
2 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
3 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
4 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
5 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
6 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
7 INT5048 Binding of Edn1 55 0.47 18.86 19.16
8 INT9191 Localization of EDN1 94 0.81 57.01 14.78
9 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
10 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
11 INT6365 Localization of Edn1 56 0.81 18.84 13.83
12 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
13 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52
14 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4
15 INT116433 Gene_expression of CYBB 93 0.70 50.44 11.91
16 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
17 INT6361 Localization of Edn1 30 0.81 19.09 9.7
18 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
19 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
20 INT10237 Binding of EDN1 40 0.48 16 8.48
21 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99
22 INT22056 Positive_regulation of CYBB 88 0.68 32.13 7.95
23 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
24 INT124297 Gene_expression of Sod2 112 0.77 65.65 7.64
25 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
26 INT103824 Positive_regulation of SOD2 26 0.70 17.42 7.17
27 INT116428 Gene_expression of Cybb 68 0.76 35.81 7.07
28 INT39282 Negative_regulation of SOD2 27 0.59 16.89 7.03
29 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91
30 INT116434 Positive_regulation of Gene_expression of CYBB 27 0.62 16.24 5.42
31 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
32 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69
33 INT20121 Negative_regulation of CYBB 34 0.54 15.5 4.44
34 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
35 INT79723 Positive_regulation of Sod2 34 0.70 24.61 3.92
36 INT141658 Positive_regulation of Gene_expression of Sod2 51 0.69 35.6 3.71
37 INT99453 Gene_expression of SOD2 25 0.77 13.28 3.6
38 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
39 INT4545 Negative_regulation of Nox1 15 0.53 10.08 3.4
40 INT162835 Positive_regulation of Cybb 38 0.68 16.09 3.02
41 INT53374 Binding of Edn1 17 0.43 11.66 2.98
42 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
43 INT91899 Binding of Sod1 17 0.47 11.56 2.63
44 INT197030 Gene_expression of Ncf1 16 0.78 11.5 2.58
45 INT31989 Binding of SOD1 43 0.47 19.38 2.55
46 INT131498 Gene_expression of Cybb 15 0.40 8.73 2.34
47 INT130230 Positive_regulation of Sod1 3 0.67 1.63 2.3
48 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
49 INT169533 Positive_regulation of Gene_expression of Cybb 16 0.68 8.62 2.14
50 INT109334 Regulation of SOD2 13 0.60 7.48 2.14
51 INT130649 Positive_regulation of Cyba 4 0.36 0.38 2.08
52 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
53 INT130648 Negative_regulation of Positive_regulation of Cyba 1 0.05 0.05 2
54 INT96764 Positive_regulation of Gene_expression of SOD1 36 0.61 16.55 1.99
55 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
56 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
57 INT69222 Positive_regulation of Sod1 15 0.61 8.19 1.87
58 INT143460 Negative_regulation of Cybb 2 0.43 3.12 1.86
59 INT145655 Transcription of Sod1 3 0.42 0.92 1.84
60 INT69221 Negative_regulation of Sod1 14 0.56 10.57 1.83
61 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
62 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
63 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
64 INT116431 Negative_regulation of Gene_expression of CYBB 11 0.39 7.88 1.72
65 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
66 INT174656 Binding of NCF1 5 0.37 6.46 1.65
67 INT27293 Regulation of SOD1 21 0.53 15.73 1.55
68 INT124299 Negative_regulation of Gene_expression of Sod2 15 0.53 13.8 1.51
69 INT178615 Binding of SOD2 12 0.48 6.93 1.51
70 INT91900 Localization of Sod1 12 0.77 6.62 1.51
71 INT152567 Positive_regulation of Gene_expression of CYBA 1 0.17 0.67 1.51
72 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
73 INT152569 Positive_regulation of Gene_expression of NOX1 1 0.31 0.67 1.51
74 INT152563 Gene_expression of CYBA 3 0.33 0.82 1.5
75 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
76 INT152560 Gene_expression of NOX1 3 0.49 0.73 1.49
77 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48
78 INT154763 Gene_expression of Nox1 3 0.67 1.83 1.48
79 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48
80 INT117101 Gene_expression of Sod1 18 0.67 7.93 1.47
81 INT154764 Localization of Nox1 1 0.65 1.07 1.47
82 INT21168 Regulation of CYBB 14 0.53 1.99 1.45
83 INT145658 Negative_regulation of Transcription of Sod1 1 0.34 0.15 1.42
84 INT242902 Gene_expression of NCF1 12 0.78 9.34 1.36
85 INT131497 Positive_regulation of Gene_expression of Cybb 4 0.01 2.09 1.3
86 INT29558 Positive_regulation of Positive_regulation of CYBB 16 0.32 2.33 1.25
87 INT116242 Negative_regulation of Cybb 11 0.57 8.57 1.24
88 INT21167 Regulation of NCF1 3 0.15 0.75 1.24
89 INT117100 Positive_regulation of Gene_expression of Sod1 5 0.60 1.18 1.2
90 INT134061 Transcription of Sod2 5 0.68 3.46 1.19
91 INT199090 Localization of Ncf1 14 0.41 5.14 1.18
92 INT17802 Transcription of Edn1 6 0.24 6.31 1.18
93 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
94 INT128970 Localization of Ncf1 6 0.68 4.25 1.1
95 INT159543 Localization of SOD1 29 0.75 8.62 1.06
96 INT129398 Negative_regulation of Gene_expression of SOD1 22 0.43 7.11 1.02
97 INT69803 Regulation of Localization of Edn1 3 0.62 0.79 0.98
98 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95
99 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95
100 INT49254 Transcription of EDN1 5 0.69 2.42 0.94
101 INT42504 Negative_regulation of Nox1 5 0.43 0.55 0.91
102 INT124300 Negative_regulation of Sod2 17 0.45 12.54 0.9
103 INT152081 Phosphorylation of Edn1 1 0.53 0.39 0.9
104 INT143466 Positive_regulation of Cybb 4 0.34 2.67 0.88
105 INT22057 Negative_regulation of Positive_regulation of CYBB 7 0.52 1.93 0.87
106 INT61591 Negative_regulation of Localization of EDN1 11 0.59 2.09 0.85
107 INT135836 Negative_regulation of Sod1 5 0.25 1.62 0.82
108 INT57433 Positive_regulation of Binding of EDN1 3 0.49 0.62 0.82
109 INT203739 Negative_regulation of NCF1 2 0.27 1.22 0.82
110 INT103823 Positive_regulation of Gene_expression of SOD2 10 0.68 4.69 0.79
111 INT197032 Regulation of Ncf1 3 0.45 2.84 0.79
112 INT199874 Binding of CYBB 6 0.32 4.31 0.77
113 INT61121 Regulation of Regulation of Edn1 1 0.43 0.2 0.75
114 INT199071 Negative_regulation of Gene_expression of Cybb 6 0.55 3.52 0.74
115 INT215261 Negative_regulation of Localization of Ncf1 6 0.30 3.51 0.74
116 INT129630 Regulation of Sod1 6 0.44 4.94 0.73
117 INT143464 Positive_regulation of Positive_regulation of Cybb 2 0.13 1.57 0.73
118 INT28561 Regulation of Gene_expression of SOD1 9 0.61 2.83 0.71
119 INT59970 Positive_regulation of Binding of Edn1 2 0.40 1.11 0.71
120 INT21957 Negative_regulation of Negative_regulation of Edn1 5 0.43 1.34 0.69
121 INT260352 Positive_regulation of Gene_expression of NCF1 1 0.50 3.34 0.69
122 INT20993 Negative_regulation of DUOX1 1 0.00 0 0.69
123 INT130651 Gene_expression of Cyba 2 0.41 0.99 0.68
124 INT130650 Negative_regulation of Gene_expression of Cyba 1 0.05 0.1 0.68
125 INT266894 Positive_regulation of Positive_regulation of Sod2 5 0.41 3.26 0.67
126 INT112173 Regulation of Transcription of SOD2 3 0.60 2.25 0.67
127 INT49252 Positive_regulation of Localization of EDN1 17 0.69 6.55 0.66
128 INT100396 Transcription of Edn1 7 0.69 2.48 0.66
129 INT108857 Transcription of SOD2 5 0.70 3.51 0.66
130 INT66783 Positive_regulation of Negative_regulation of Nox1 1 0.63 0.81 0.66
131 INT49256 Regulation of Positive_regulation of EDN1 2 0.45 2.5 0.65
132 INT270033 Regulation of Gene_expression of Sod2 5 0.45 2.34 0.63
133 INT199875 Localization of CYBB 16 0.72 5.77 0.62
134 INT66903 Positive_regulation of Nox1 3 0.25 1.1 0.62
135 INT147440 Gene_expression of Nox1 3 0.57 1.61 0.6
136 INT111960 Binding of Sod2 4 0.37 2.03 0.59
137 INT108856 Regulation of Gene_expression of SOD2 3 0.44 0.79 0.58
138 INT7153 Positive_regulation of Regulation of Edn1 2 0.35 1.97 0.57
139 INT135715 Negative_regulation of Localization of Edn1 5 0.42 1.7 0.56
140 INT79725 Regulation of Sod2 8 0.61 4.95 0.54
141 INT63910 Regulation of Positive_regulation of Edn1 2 0.43 0.64 0.54
142 INT199096 Phosphorylation of Ncf1 8 0.42 1.55 0.53
143 INT162429 Negative_regulation of Gene_expression of Sod1 6 0.48 2.46 0.53
144 INT131641 Negative_regulation of Negative_regulation of Edn1 1 0.37 0.31 0.52
145 INT181581 Regulation of Positive_regulation of Edn1 4 0.23 3.76 0.51
146 INT249248 Transcription of CYBB 2 0.60 1.05 0.49
147 INT197037 Negative_regulation of Ncf1 1 0.43 1.49 0.49
148 INT27543 Positive_regulation of ALOX12 1 0.09 2.09 0.48
149 INT330084 Positive_regulation of Nox3 1 0.25 0.86 0.48
150 INT55372 Regulation of Localization of Edn1 2 0.38 0.64 0.46
151 INT254539 Regulation of Transcription of CYBB 1 0.39 0.85 0.46
152 INT57434 Regulation of Regulation of EDN1 1 0.40 0.47 0.44
153 INT142324 Gene_expression of Ncf1 19 0.75 10.8 0.41
154 INT199078 Gene_expression of Nox4 3 0.59 3.83 0.41
155 INT199064 Phosphorylation of Ncf2 6 0.48 0.27 0.39
156 INT65962 Negative_regulation of NOX1 1 0.07 0.89 0.39
157 INT81433 Negative_regulation of Positive_regulation of Edn1 4 0.39 0.81 0.38
158 INT124298 Localization of Sod2 8 0.74 3.5 0.37
159 INT187472 Regulation of Gene_expression of Sod1 5 0.53 2.68 0.37
160 INT159542 Localization of SOD2 5 0.80 1.91 0.36
161 INT113368 Regulation of Negative_regulation of Edn1 1 0.45 0.71 0.35
162 INT257334 Gene_expression of Cyba 12 0.53 5.39 0.34
163 INT141013 Regulation of Gene_expression of Edn1 2 0.24 0.55 0.34
164 INT144475 Protein_catabolism of Sod2 1 0.17 0.58 0.33
165 INT235216 Localization of Cybb 7 0.78 4.3 0.31
166 INT199073 Positive_regulation of Ncf1 7 0.27 3.64 0.31
167 INT16368 Protein_catabolism of Edn1 2 0.72 0.18 0.31
168 INT330088 Binding of Cybb 1 0.26 0.7 0.31
169 INT77362 Localization of DUOX1 1 0.06 0 0.3
170 INT129632 Negative_regulation of Transcription of Sod1 1 0.43 0.69 0.28
171 INT129631 Transcription of Sod1 1 0.52 0.69 0.28
172 INT199089 Transcription of Cybb 5 0.67 1.16 0.27
173 INT260350 Negative_regulation of Gene_expression of NCF1 1 0.43 1.47 0.27
174 INT319179 Positive_regulation of Positive_regulation of SOD2 1 0.68 0.51 0.27
175 INT84038 Protein_catabolism of Edn1 2 0.86 0.69 0.26
176 INT199098 Positive_regulation of Positive_regulation of Cybb 2 0.47 0.24 0.26
177 INT199094 Positive_regulation of Phosphorylation of Ncf1 2 0.36 0.55 0.26
178 INT129399 Transcription of SOD1 6 0.66 3.08 0.25
179 INT199079 Localization of Ncf2 3 0.21 1.17 0.25
180 INT257315 Positive_regulation of Gene_expression of Cyba 8 0.47 4.04 0.24
181 INT199085 Binding of Ncf2 3 0.16 0.43 0.24
182 INT199092 Binding of Ncf1 3 0.19 0.43 0.24
183 INT109333 Negative_regulation of Gene_expression of SOD2 2 0.42 0.71 0.24
184 INT254538 Negative_regulation of Localization of CYBB 3 0.37 1.54 0.22
185 INT220727 Regulation of Binding of SOD1 1 0.42 1.46 0.21
186 INT67265 Positive_regulation of Negative_regulation of Edn1 1 0.61 0.05 0.21
187 INT345296 Positive_regulation of Localization of CYBB 1 0.02 0.78 0.21
188 INT238309 Negative_regulation of Gene_expression of Sod1 3 0.38 1.09 0.2
189 INT116432 Positive_regulation of Positive_regulation of SOD1 3 0.40 3.88 0.2
190 INT343013 Positive_regulation of NOX5 1 0.15 2.03 0.2
191 INT156920 Phosphorylation of EDN1 4 0.61 0.66 0.19
192 INT174127 Positive_regulation of Positive_regulation of Sod1 2 0.45 4.9 0.19
193 INT53372 Positive_regulation of Regulation of Edn1 1 0.50 0 0.19
194 INT100397 Regulation of Transcription of Edn1 1 0.00 0.1 0.19
195 INT249259 Regulation of Regulation of CYBB 1 0.17 0.07 0.19
196 INT240279 Negative_regulation of Positive_regulation of SOD1 5 0.43 2.45 0.18
197 INT234591 Gene_expression of Ncf2 3 0.52 0.17 0.18
198 INT269033 Regulation of Gene_expression of Cybb 1 0.42 0.29 0.18
199 INT179450 Positive_regulation of NCF1 5 0.50 1.04 0.17
200 INT254544 Regulation of Gene_expression of CYBB 3 0.39 0.85 0.17
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