GO:0042609

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Name CD4 receptor binding
Categary Function
Go Slim No
Go Link GO:0042609
Unique Molecular Interactions 34
Total Molecular Interactions 41
Total Single Events 241
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for CD4 receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for CD4 receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT144449 Plscr1 Positive_regulation of Gene_expression of Nqo1 1 0.15 0.18 0.8
2 INT325259 Il33 Positive_regulation of Gene_expression of Spg21 1 0.07 1.23 0.53
3 INT160445 Tpsab1 Positive_regulation of Gene_expression of SPG21 1 0.48 0.96 0.48
4 INT325269 Il33 Positive_regulation of Spg21 1 0.05 1.11 0.48
5 INT312814 TNF Positive_regulation of Spg21 1 0.00 0.6 0.45
6 INT181451 Lck Regulation of Mbp 1 0.08 1.43 0.34
7 INT325266 Positive_regulation of Spg21 Positive_regulation of Il33 1 0.05 0.75 0.32
8 INT100725 TNF Positive_regulation of Localization of SPG21 1 0.28 0.66 0.31
9 INT107007 SPG21 Positive_regulation of NR1I2 1 0.39 0.39 0.22
10 INT207142 Spg21 Positive_regulation of Par2 1 0.02 0.48 0.17
11 INT213807 Mitf Positive_regulation of Spg21 1 0.05 1.2 0.15
12 INT213811 Tfe3 Positive_regulation of Spg21 1 0.05 1.21 0.15
13 INT107002 PAR1 Positive_regulation of SPG21 1 0.24 0.29 0.14
14 INT106995 PRSS1 Positive_regulation of SPG21 1 0.04 0.29 0.14
15 INT107006 PARD3 Positive_regulation of SPG21 1 0.24 0.29 0.14
16 INT106996 PAR4 Positive_regulation of SPG21 1 0.29 0.29 0.14
17 INT325268 Il1rl1 Positive_regulation of Gene_expression of Spg21 1 0.05 0.41 0.12
18 INT338420 Il9 Positive_regulation of Gene_expression of Spg21 1 0.01 0.31 0.07
19 INT221639 Fyn Positive_regulation of Phosphorylation of Cdk5 1 0.14 0.28 0.03
20 INT221624 Binding of Fyn and Plxna1 1 0.01 0.29 0.03
21 INT259935 CSK Positive_regulation of Negative_regulation of LCK 1 0.09 0.57 0.03
22 INT221640 Sema3a Positive_regulation of Phosphorylation of Fyn 1 0.16 0.29 0.03
23 INT221651 Binding of Fyn and Plxna2 1 0.01 0.29 0.03
24 INT221623 Fyn Regulation of Fes 1 0.14 0.2 0.03
25 INT259940 CSK Positive_regulation of Phosphorylation of LCK 1 0.09 0.51 0.03
26 INT329729 Binding of LCK and Fyn 1 0.00 0.21 0.03
27 INT221613 Binding of Cdk5 and Fyn 1 0.10 0.29 0.03
28 INT221617 Fyn Positive_regulation of Cdk5 1 0.13 0.28 0.03
29 INT298848 Binding of SPG21 and RILP 1 0.10 0.21 0
30 INT228118 Binding of Fyn and Vav1 1 0.11 0.21 0
31 INT303987 Binding of LEPR and Fyn 1 0.02 0.62 0
32 INT275190 Localization of CD4 Positive_regulation of Positive_regulation of LCK 1 0.10 0.99 0
33 INT221645 Fyn Regulation of Phosphorylation of Fer 1 0.12 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for CD4 receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in CD4 receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT181488 Positive_regulation of Spg21 13 0.12 15.52 10.03
2 INT63365 Gene_expression of Spg21 21 0.65 12.9 7.37
3 INT181489 Localization of Spg21 16 0.12 10.89 6.84
4 INT213769 Binding of Spg21 18 0.03 7.96 6.77
5 INT229912 Phosphorylation of Fyn 5 0.42 2.57 3.78
6 INT161310 Negative_regulation of LCK 17 0.42 8.75 2.74
7 INT74064 Gene_expression of SPG21 9 0.75 4.14 2.45
8 INT130476 Phosphorylation of Fyn 8 0.80 2.99 2.44
9 INT122671 Positive_regulation of LCK 4 0.13 2.69 2.14
10 INT50740 Positive_regulation of SPG21 18 0.67 8.3 1.65
11 INT114270 Gene_expression of Plscr1 6 0.47 1.33 1.49
12 INT122672 Regulation of Positive_regulation of LCK 1 0.06 1.15 1.44
13 INT130477 Negative_regulation of Fyn 3 0.29 1.59 1.14
14 INT248588 Gene_expression of LCK 9 0.28 4.9 0.98
15 INT123948 Positive_regulation of Plscr1 4 0.42 1.02 0.93
16 INT61042 Localization of SPG21 5 0.78 1.42 0.89
17 INT114275 Regulation of Gene_expression of Plscr1 2 0.24 0.51 0.85
18 INT146940 Gene_expression of Fyn 2 0.52 2.76 0.83
19 INT161311 Positive_regulation of Negative_regulation of LCK 2 0.45 0.74 0.83
20 INT146942 Gene_expression of Lck 1 0.46 1.3 0.83
21 INT316686 Negative_regulation of Spg21 2 0.05 3.34 0.8
22 INT122670 Negative_regulation of Positive_regulation of LCK 1 0.06 0.58 0.72
23 INT213782 Regulation of Spg21 2 0.03 1.41 0.66
24 INT329708 Transcription of LCK 1 0.04 1.54 0.63
25 INT249509 Gene_expression of Fyn 2 0.35 1.79 0.56
26 INT213776 Positive_regulation of Gene_expression of Spg21 1 0.05 0.95 0.45
27 INT312831 Negative_regulation of Lck 3 0.13 2.46 0.36
28 INT329707 Negative_regulation of Transcription of LCK 1 0.04 0.9 0.35
29 INT207132 Negative_regulation of Positive_regulation of Spg21 1 0.02 0.7 0.35
30 INT249525 Positive_regulation of Gene_expression of Fyn 1 0.21 0.23 0.34
31 INT181413 Regulation of Lck 2 0.36 2.54 0.33
32 INT249523 Regulation of Localization of Fyn 1 0.19 0.22 0.32
33 INT249516 Negative_regulation of Gene_expression of Fyn 1 0.18 0.23 0.32
34 INT249510 Localization of Fyn 1 0.32 0.22 0.29
35 INT123954 Transcription of Plscr1 1 0.28 0.09 0.27
36 INT123957 Regulation of Plscr1 1 0.11 0.09 0.27
37 INT123953 Regulation of Transcription of Plscr1 1 0.14 0.09 0.27
38 INT270161 Positive_regulation of Phosphorylation of Lck 1 0.13 0.23 0.23
39 INT278159 Regulation of LCK 1 0.04 0.98 0.22
40 INT278161 Localization of LCK 1 0.27 0.98 0.22
41 INT338874 Binding of Fyn 1 0.08 0.53 0.19
42 INT327722 Positive_regulation of Localization of Spg21 1 0.05 0.85 0.17
43 INT81881 Negative_regulation of SPG21 1 0.41 0.41 0.13
44 INT278162 Negative_regulation of Gene_expression of LCK 1 0.15 0.64 0.12
45 INT275204 Binding of LCK 2 0.12 1.19 0.11
46 INT270159 Positive_regulation of Lck 1 0.09 0.12 0.11
47 INT270153 Phosphorylation of Lck 1 0.15 0.11 0.11
48 INT114500 Transcription of SPG21 1 0.52 0.35 0.1
49 INT199074 Positive_regulation of Fyn 1 0.18 0.05 0.07
50 INT259943 Phosphorylation of LCK 1 0.33 1.02 0.06
51 INT270639 Binding of Lck 2 0.30 1.21 0.05
52 INT325232 Regulation of Gene_expression of Spg21 1 0.04 0.33 0.05
53 INT149789 Positive_regulation of Phosphorylation of Fyn 2 0.67 0.31 0.04
54 INT259944 Positive_regulation of Phosphorylation of LCK 1 0.18 0.56 0.03
55 INT329716 Negative_regulation of Fyn 1 0.03 0.21 0.03
56 INT133452 Positive_regulation of Gene_expression of SPG21 1 0.45 0.17 0
57 INT133451 Positive_regulation of Positive_regulation of SPG21 1 0.49 0.19 0
58 INT275212 Positive_regulation of Gene_expression of LCK 1 0.14 0.97 0
59 INT160042 Regulation of Gene_expression of SPG21 1 0.44 0.16 0
60 INT155831 Transcription of Spg21 1 0.52 0 0
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