GO:0042699

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Name follicle-stimulating hormone signaling pathway
Categary Process
Go Slim No
Go Link GO:0042699
Unique Molecular Interactions 111
Total Molecular Interactions 134
Total Single Events 1142
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for follicle-stimulating hormone signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for follicle-stimulating hormone signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
2 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
3 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
4 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
5 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
6 INT169801 Binding of Adrbk1 and Rapgef3 1 0.34 1.04 1.43
7 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
8 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
9 INT166301 Adrbk1 Positive_regulation of Localization of Trpv1 1 0.45 1.17 1.2
10 INT169802 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Rapgef3 1 0.44 0.75 1.19
11 INT25026 PLOD1 Regulation of FSHR 4 0.19 0.38 1.15
12 INT146496 Snta1 Positive_regulation of Gene_expression of Adrbk1 1 0.13 0.73 1.05
13 INT146097 Positive_regulation of Binding of Rgs9 and Arrb2 1 0.28 0 1.04
14 INT146098 Binding of Rgs9 and Arrb2 1 0.19 0 1.03
15 INT143916 Arrb2 Regulation of Rbm39 1 0.04 0.18 1
16 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98
17 INT111632 Arrb2 Negative_regulation of Regulation of Rbm39 1 0.03 0 0.96
18 INT146495 Snta1 Positive_regulation of Adrbk1 1 0.14 0.68 0.85
19 INT139745 Positive_regulation of Binding of Oprm1 and Arrb2 1 0.28 0.14 0.81
20 INT85686 Binding of Arrb1 and Arrb2 1 0.14 0.09 0.79
21 INT124384 ADRBK1 Negative_regulation of MC1R 1 0.40 0.42 0.77
22 INT140235 ADRBK1 Positive_regulation of Binding of MC1R 1 0.46 0.31 0.68
23 INT140237 Gene_expression of ADRBK1 Positive_regulation of Gene_expression of MC1R 1 0.46 0.31 0.68
24 INT35159 FSHR Regulation of PRL 2 0.34 0 0.6
25 INT60537 Gnrh1 Positive_regulation of Localization of FSHR 1 0.00 0.19 0.6
26 INT166300 Adrbk1 Positive_regulation of Negative_regulation of Gpbar1 1 0.39 0.63 0.58
27 INT54584 GNRH1 Positive_regulation of FSHR 3 0.48 2.02 0.54
28 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
29 INT106392 ADRBK1 Regulation of Negative_regulation of OPRL1 1 0.27 0.06 0.52
30 INT151222 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Adrbk1 1 0.00 0.13 0.51
31 INT151223 Negative_regulation of SIGMAR1 Negative_regulation of Adrbk1 1 0.00 0.13 0.51
32 INT81331 ADRBK1 Regulation of OPRK1 1 0.03 0.09 0.48
33 INT8317 Fshr Regulation of Localization of LH 1 0.29 0 0.48
34 INT39178 NPL Regulation of FSHR 1 0.03 0 0.46
35 INT25027 CRH Negative_regulation of Negative_regulation of FSHR 1 0.25 0 0.42
36 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
37 INT156122 Phosphorylation of Src Positive_regulation of Adrbk1 1 0.01 0 0.37
38 INT143914 Binding of Rbm39 and Arrb2 1 0.03 0.07 0.37
39 INT265145 Calm2 Negative_regulation of Phosphorylation of Adrbk1 1 0.05 0.07 0.35
40 INT12522 Binding of FSHR and POMC 1 0.33 3.89 0.34
41 INT31044 Gnrh1 Negative_regulation of Localization of FSHR 1 0.04 0 0.32
42 INT31040 Ghrh Positive_regulation of Localization of FSHR 1 0.05 0 0.31
43 INT106397 Positive_regulation of OPRL1 Positive_regulation of ADRBK1 1 0.46 0.09 0.31
44 INT102976 Binding of ADRBK1 and Rbm39 1 0.00 0 0.31
45 INT265138 Adrbk1 Positive_regulation of Localization of Chrm1 1 0.07 0 0.31
46 INT31041 Ghrh Positive_regulation of FSHR 1 0.05 0 0.31
47 INT116680 Binding of ADRBK1 and Oxtr 1 0.18 0.14 0.3
48 INT102955 OPRK1 Positive_regulation of Localization of ADRBK1 1 0.13 0 0.3
49 INT35080 CRH Negative_regulation of Localization of FSHR 1 0.03 0 0.29
50 INT44441 GNRH1 Positive_regulation of Localization of FSHR 2 0.15 0.86 0.26
51 INT8303 Fshr Regulation of Localization of Gnrh1 1 0.16 0 0.24
52 INT8299 Fshr Regulation of Grp 1 0.10 0 0.23
53 INT8321 Fshr Regulation of Grpr 1 0.09 0 0.23
54 INT8322 Fshr Regulation of Rgn 1 0.01 0 0.23
55 INT224087 Adrbk1 Negative_regulation of Adora2a 1 0.10 0.13 0.22
56 INT35162 GH1 Regulation of FSHR 1 0.17 0 0.21
57 INT35161 FSHR Regulation of LHB 1 0.18 0 0.21
58 INT35153 FSHR Regulation of GHRH 1 0.04 0 0.21
59 INT35156 FSHR Regulation of PGR 1 0.18 0 0.21
60 INT25052 Crh Regulation of FSHR 1 0.08 0 0.19
61 INT266046 Cstb Regulation of Gene_expression of Adrm1 1 0.00 0.7 0.18
62 INT224094 Adrbk1 Regulation of Negative_regulation of Adora2a 1 0.06 0 0.17
63 INT25054 Crh Negative_regulation of FSHR 1 0.07 0 0.17
64 INT65677 Binding of CGA and FSHR 2 0.25 0.29 0.16
65 INT224092 Adrbk1 Regulation of Grk5 1 0.08 0 0.16
66 INT102975 ADRBK1 Regulation of Localization of Rbm39 1 0.00 0 0.15
67 INT21302 Gnrh1 Positive_regulation of Positive_regulation of Fshr 1 0.25 0 0.15
68 INT102954 Binding of ADRBK1 and OPRK1 1 0.11 0 0.14
69 INT122235 Fshb Regulation of Gene_expression of LH 1 0.14 0 0.12
70 INT122223 Fshb Regulation of Gene_expression of Gnrh1 1 0.23 0 0.12
71 INT122238 Fshb Regulation of Gene_expression of Pomc 1 0.01 0 0.12
72 INT284891 FSHR Positive_regulation of Gene_expression of PLOD1 2 0.03 1.32 0.11
73 INT72849 RT1-EC2 Positive_regulation of Adrbk1 1 0.01 0.33 0.1
74 INT147936 CGA Regulation of Gene_expression of FSHR 1 0.31 0.71 0.1
75 INT72847 Adrbk2 Positive_regulation of Adrbk1 1 0.02 0.33 0.1
76 INT12523 Binding of FSHR and LHB 1 0.11 0.98 0.09
77 INT12520 Binding of FSHR and GANAB 1 0.03 0.97 0.09
78 INT223039 Gene_expression of TFPI Positive_regulation of Gene_expression of ADRBK1 1 0.11 0 0.07
79 INT320440 Binding of Adrm1 and Psmb10 1 0.00 0 0.04
80 INT334918 GNRH1 Positive_regulation of Gene_expression of FSHR 2 0.11 1.27 0.03
81 INT223041 Binding of ADRBK1 and TFPI 1 0.08 0 0.03
82 INT350114 Positive_regulation of GNRH1 Positive_regulation of FSHR 1 0.05 0.86 0.03
83 INT187677 Negative_regulation of FSHR Positive_regulation of DBT 1 0.03 0 0
84 INT350120 FSHR Regulation of CYP19A1 1 0.01 3.02 0
85 INT223037 SLURP1 Positive_regulation of Gene_expression of ADRBK1 1 0.02 0 0
86 INT350117 GNRHR Negative_regulation of Localization of FSHR 1 0.01 1.06 0
87 INT222535 Binding of Gh1 and Fshb 1 0.01 0 0
88 INT187674 FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.24 0 0
89 INT25051 Crh Negative_regulation of Localization of FSHR 1 0.07 0 0
90 INT222423 Binding of Pomc and Fshb 1 0.01 0 0
91 INT350116 FSHR Positive_regulation of Gene_expression of CGA 1 0.01 1.28 0
92 INT284892 AMH Regulation of Localization of FSHR 1 0.01 0.18 0
93 INT356140 Fshb Regulation of FSHR 1 0.04 0.28 0
94 INT44233 Binding of FSHR and TRH 1 0.34 0.9 0
95 INT334917 GNRHR Positive_regulation of Gene_expression of FSHR 1 0.05 0.53 0
96 INT270758 GNRHR Positive_regulation of Localization of FSHR 1 0.08 0.68 0
97 INT222526 Binding of Prl and Fshb 1 0.03 0 0
98 INT176569 Binding of FSHR and Cyp19a1 1 0.04 0.06 0
99 INT295432 FSHR Positive_regulation of PCOS1 1 0.06 1.24 0
100 INT187669 FSHR Positive_regulation of DBT 1 0.03 0 0
101 INT253945 Adrm1 Negative_regulation of Hdl1 1 0.00 1.18 0
102 INT350122 GNRH1 Negative_regulation of Localization of FSHR 1 0.05 0.99 0
103 INT44232 FSHR Regulation of PLOD1 1 0.15 0.9 0
104 INT44229 TRH Regulation of FSHR 1 0.11 0.9 0
105 INT187670 Gene_expression of FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.16 0 0
106 INT44231 Negative_regulation of Binding of FSHR and TRH 1 0.39 0.91 0
107 INT156781 Binding of Esr1 and Fshr 1 0.02 0 0
108 INT295431 FSHR Positive_regulation of CGA 1 0.29 0.27 0
109 INT156780 Esr1 Positive_regulation of Binding of Fshr 1 0.02 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for follicle-stimulating hormone signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in follicle-stimulating hormone signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1644 Regulation of FSHR 77 0.55 15.62 21.49
2 INT50778 Gene_expression of Adrbk1 24 0.77 11.61 20.73
3 INT54708 Gene_expression of Adrbk1 22 0.75 1.06 20.62
4 INT112930 Negative_regulation of Adrbk1 17 0.58 15.04 20.41
5 INT912 Localization of FSHR 91 0.79 23.61 15.58
6 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33
7 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04
8 INT94981 Gene_expression of Arrb2 12 0.70 2.11 11.75
9 INT143098 Negative_regulation of Gene_expression of Adrbk1 9 0.58 8.51 11.37
10 INT54706 Regulation of Adrbk1 11 0.62 0.89 10.69
11 INT54707 Positive_regulation of Adrbk1 14 0.67 0.51 9.51
12 INT1647 Negative_regulation of FSHR 54 0.45 13.44 8.87
13 INT81345 Gene_expression of ADRBK1 21 0.70 2.89 7.9
14 INT98856 Negative_regulation of Gene_expression of Adrbk1 5 0.56 0.43 7.29
15 INT50779 Positive_regulation of Gene_expression of Adrbk1 9 0.56 2.79 7.23
16 INT100079 Positive_regulation of Gene_expression of Arrb2 7 0.63 2.26 6.77
17 INT94979 Regulation of Arrb2 6 0.54 0.51 6.45
18 INT94986 Positive_regulation of Arrb2 5 0.61 1.3 6.24
19 INT4629 Regulation of Fshb 12 0.49 1.93 5.95
20 INT85685 Gene_expression of Arrb2 5 0.74 0.66 5.13
21 INT924 Regulation of Localization of FSHR 15 0.45 1.4 5.07
22 INT923 Positive_regulation of Localization of FSHR 14 0.43 2.48 4.96
23 INT85681 Negative_regulation of Arrb2 5 0.47 0.79 4.71
24 INT108935 Transcription of Arrb2 5 0.59 0.5 4.38
25 INT92797 Regulation of Arrb2 4 0.44 0.81 4.28
26 INT94985 Regulation of Gene_expression of Arrb2 2 0.40 0.43 4.2
27 INT100741 Positive_regulation of ADRBK1 10 0.64 1.01 3.95
28 INT85679 Binding of Arrb2 4 0.39 0.79 3.82
29 INT212563 Gene_expression of Adrm1 26 0.13 11.46 3.58
30 INT94983 Negative_regulation of Arrb2 2 0.52 0.26 3.47
31 INT1646 Negative_regulation of Localization of FSHR 17 0.58 7.36 3.46
32 INT542 Gene_expression of Fshb 14 0.75 5.22 3.24
33 INT54709 Positive_regulation of Gene_expression of Adrbk1 6 0.49 0.18 3.12
34 INT105840 Regulation of Gene_expression of Adrbk1 2 0.44 0.16 3.09
35 INT85682 Positive_regulation of Arrb2 4 0.46 0.22 3.05
36 INT102969 Positive_regulation of Gene_expression of ADRBK1 7 0.46 1.21 2.87
37 INT99592 Regulation of Adrbk1 3 0.61 1.46 2.84
38 INT110503 Negative_regulation of ADRBK1 4 0.53 0.71 2.69
39 INT10070 Negative_regulation of Fshb 13 0.42 3.48 2.5
40 INT94978 Negative_regulation of Adrbk1 6 0.38 0.13 2.47
41 INT221762 Regulation of Gene_expression of Adrm1 4 0.07 4.45 2.42
42 INT108937 Negative_regulation of Transcription of Arrb2 1 0.38 0.31 2.31
43 INT72842 Phosphorylation of Adrbk1 5 0.47 0.58 2.16
44 INT108939 Regulation of Transcription of Arrb2 1 0.24 0.19 2.1
45 INT146491 Binding of Adrbk1 3 0.48 1.58 2.09
46 INT102970 Localization of ADRBK1 4 0.66 0.45 1.85
47 INT183276 Negative_regulation of Adrm1 10 0.04 7.25 1.74
48 INT33496 Positive_regulation of Gene_expression of FSHR 14 0.46 6.05 1.66
49 INT125844 Positive_regulation of Gene_expression of Arrb2 2 0.48 0.45 1.66
50 INT73870 Positive_regulation of Regulation of Adrbk1 1 0.47 0.17 1.66
51 INT7033 Binding of FSHR 19 0.37 6.66 1.52
52 INT94965 Transcription of Adrbk1 2 0.22 0.13 1.52
53 INT1641 Positive_regulation of Negative_regulation of FSHR 3 0.41 1.7 1.43
54 INT108936 Positive_regulation of Positive_regulation of Arrb2 1 0.41 0.25 1.4
55 INT151216 Positive_regulation of Adrbk1 2 0.46 0.9 1.3
56 INT94967 Localization of Adrbk1 2 0.26 0.33 1.21
57 INT25032 Negative_regulation of Gene_expression of FSHR 11 0.39 1.99 1.2
58 INT302068 Phosphorylation of Arrb2 1 0.01 0.27 1.19
59 INT112931 Negative_regulation of Localization of Adrbk1 1 0.37 0 1.13
60 INT112932 Localization of Adrbk1 1 0.69 0 1.12
61 INT106404 Positive_regulation of Positive_regulation of ADRBK1 2 0.41 0.31 1.08
62 INT3725 Localization of Fshb 10 0.68 2.24 1.04
63 INT98849 Binding of Adrbk1 3 0.36 0.18 1.04
64 INT98855 Negative_regulation of Binding of Adrbk1 2 0.41 0.18 1.04
65 INT146492 Positive_regulation of Negative_regulation of Adrbk1 1 0.50 0.74 1
66 INT108943 Positive_regulation of Negative_regulation of Arrb2 1 0.61 0.06 0.97
67 INT111883 Negative_regulation of Transcription of Adrbk1 1 0.33 0 0.93
68 INT111887 Transcription of Adrbk1 1 0.56 0 0.92
69 INT35299 Regulation of Positive_regulation of FSHR 1 0.05 0 0.91
70 INT25030 Negative_regulation of Negative_regulation of FSHR 2 0.25 0 0.79
71 INT85678 Binding of Arrb1 1 0.20 0.09 0.78
72 INT110511 Regulation of ADRBK1 1 0.22 0.22 0.76
73 INT110505 Positive_regulation of Negative_regulation of ADRBK1 1 0.38 0.22 0.76
74 INT54710 Regulation of Regulation of Adrbk1 1 0.37 0 0.69
75 INT34892 Transcription of FSHR 2 0.27 0.08 0.68
76 INT78183 Negative_regulation of Adrm1 8 0.09 3.4 0.65
77 INT212562 Positive_regulation of Adrm1 16 0.10 5.08 0.62
78 INT224102 Negative_regulation of Localization of Adrbk1 1 0.19 0.44 0.61
79 INT147679 Binding of Arrb2 1 0.24 0.22 0.58
80 INT137480 Positive_regulation of Positive_regulation of Adrbk1 1 0.44 0.06 0.55
81 INT126960 Phosphorylation of ADRBK1 2 0.66 0.06 0.52
82 INT34890 Regulation of Transcription of FSHR 1 0.17 0 0.52
83 INT105210 Positive_regulation of Adrm1 7 0.06 4.09 0.5
84 INT116677 Binding of ADRBK1 6 0.44 0.65 0.5
85 INT224110 Positive_regulation of Phosphorylation of Adrbk1 2 0.28 0 0.45
86 INT86728 Negative_regulation of Positive_regulation of Adrbk1 1 0.38 0 0.45
87 INT250468 Positive_regulation of Gene_expression of Adrm1 2 0.04 2.26 0.44
88 INT168112 Phosphorylation of Arrb2 1 0.00 0 0.41
89 INT15621 Positive_regulation of Fshb 2 0.23 0.34 0.4
90 INT156120 Localization of Arrb1 1 0.00 0 0.38
91 INT150812 Regulation of Regulation of Arrb2 1 0.26 0 0.38
92 INT156119 Positive_regulation of Localization of Arrb1 1 0.00 0 0.38
93 INT212565 Regulation of Adrm1 3 0.04 2.41 0.36
94 INT21304 Positive_regulation of Fshr 2 0.40 0.2 0.35
95 INT3726 Regulation of Localization of Fshb 1 0.44 0 0.35
96 INT212564 Negative_regulation of Gene_expression of Adrm1 3 0.05 1.7 0.34
97 INT25047 Positive_regulation of Regulation of FSHR 3 0.31 0.92 0.29
98 INT28069 Binding of Fshb 1 0.11 0.06 0.25
99 INT7977 Regulation of Gene_expression of FSHR 4 0.44 0.79 0.24
100 INT116676 Negative_regulation of Binding of ADRBK1 2 0.53 0.33 0.23
101 INT45939 Negative_regulation of Gene_expression of Fshb 1 0.07 0 0.23
102 INT250467 Localization of Adrm1 2 0.06 0.97 0.19
103 INT250469 Positive_regulation of Localization of Adrm1 2 0.04 0.97 0.19
104 INT186140 Gene_expression of Adrm1 2 0.06 1.01 0.18
105 INT7036 Negative_regulation of Regulation of FSHR 2 0.29 0.14 0.17
106 INT224104 Regulation of Phosphorylation of Adrbk1 1 0.14 0.07 0.17
107 INT21303 Localization of Fshr 1 0.40 0 0.15
108 INT181222 Phosphorylation of Adrbk1 1 0.16 0 0.14
109 INT210482 Regulation of Regulation of FSHR 1 0.03 0.07 0.12
110 INT223056 Regulation of Gene_expression of ADRBK1 1 0.22 0 0.12
111 INT151342 Positive_regulation of Positive_regulation of FSHR 5 0.20 1.79 0.11
112 INT86945 Positive_regulation of Localization of Fshb 2 0.08 0.4 0.11
113 INT212172 Binding of Adrm1 7 0.36 1.38 0.09
114 INT76969 Negative_regulation of Negative_regulation of Fshb 1 0.04 0.72 0.09
115 INT215445 Transcription of Adrm1 2 0.08 0.08 0.05
116 INT222582 Gene_expression of Fshr 1 0.10 0.65 0.03
117 INT10074 Transcription of Fshb 1 0.48 0 0
118 INT161736 Negative_regulation of Gene_expression of Arrb2 1 0.50 0 0
119 INT176565 Protein_catabolism of FSHR 1 0.26 0.13 0
120 INT267790 Binding of Adrm1 1 0.07 0 0
121 INT132329 Regulation of Negative_regulation of FSHR 1 0.13 0.17 0
122 INT317587 Negative_regulation of Negative_regulation of Adrm1 1 0.03 0 0
123 INT223046 Positive_regulation of Localization of ADRBK1 1 0.24 0 0
124 INT161016 Transcription of Fshr 1 0.24 0.28 0
125 INT317588 Regulation of Adrm1 1 0.05 0 0
126 INT181220 Negative_regulation of Binding of Adrbk1 1 0.11 0 0
127 INT156779 Binding of Fshr 1 0.05 0 0
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