GO:0042733

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Name embryonic digit morphogenesis
Categary Process
Go Slim No
Go Link GO:0042733
Unique Molecular Interactions 360
Total Molecular Interactions 444
Total Single Events 2999
Pain Genes Associated 39

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for embryonic digit morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported for embryonic digit morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
2 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
3 INT48881 TWIST1 Positive_regulation of Localization of Abat 1 0.02 0.44 1.29
4 INT270053 HOXD12 Positive_regulation of Gene_expression of GAD1 1 0.03 0.68 1.12
5 INT270054 HOXD12 Positive_regulation of Gene_expression of SFTPA1 1 0.01 0.68 1.12
6 INT154236 Binding of TBX3 and Ugt2b7 1 0.41 0.74 1
7 INT275097 Twist1 Regulation of Ltp 1 0.01 0.37 0.96
8 INT142709 Binding of TWIST1 and CEBPZ 2 0.17 1.16 0.95
9 INT141276 Negative_regulation of Il18 Negative_regulation of Gene_expression of Hand2 1 0.25 0.8 0.92
10 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
11 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
12 INT128180 Gna12 Regulation of Regulation of RHOA 1 0.00 0 0.78
13 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
14 INT243626 Twist1 Regulation of Hand1 1 0.15 1.55 0.72
15 INT262574 Gnaq Positive_regulation of Prkca 1 0.00 0.57 0.71
16 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69
17 INT68561 Binding of Gli3 and Ust 1 0.01 0.68 0.68
18 INT224823 CTBS Regulation of SALL1 1 0.14 0.53 0.66
19 INT243639 Twist1 Negative_regulation of Gene_expression of Il2 1 0.24 1.28 0.65
20 INT102864 Prkaca Regulation of Twist1 1 0.48 0.05 0.58
21 INT102364 BRD1 Positive_regulation of Twist1 1 0.00 0 0.47
22 INT117531 Twist1 Regulation of CSAD 1 0.00 0.85 0.47
23 INT338426 Binding of Hand1 and Hand2 2 0.06 2 0.46
24 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46
25 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46
26 INT102862 Prkaca Regulation of Phosphorylation of Twist1 1 0.19 0.1 0.42
27 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
28 INT116936 Positive_regulation of GLI2 Positive_regulation of JUN 1 0.12 0.07 0.41
29 INT152158 NENF Regulation of TWIST1 1 0.01 0.33 0.4
30 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
31 INT173356 Gnaq Positive_regulation of CDK20 1 0.06 0 0.37
32 INT305853 Polk Regulation of Gene_expression of Hand2 1 0.12 0.93 0.35
33 INT168202 Msx1 Negative_regulation of Gene_expression of Mc1r 1 0.21 0.49 0.35
34 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
35 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
36 INT243627 Twist1 Regulation of Gene_expression of Ik 1 0.01 0.13 0.34
37 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34
38 INT266806 Hand2 Regulation of Gene_expression of IL10 1 0.00 1.23 0.32
39 INT241139 Ighg1 Positive_regulation of Hand2 1 0.06 0.65 0.32
40 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
41 INT181433 Hand2 Regulation of Gene_expression of Ccl2 1 0.12 0.68 0.32
42 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
43 INT266804 Hand2 Regulation of Gene_expression of IL13 1 0.00 1.23 0.32
44 INT266805 Hand2 Regulation of Gene_expression of IL4 1 0.00 1.23 0.32
45 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
46 INT243641 Twist1 Positive_regulation of Socs1 1 0.14 0.13 0.31
47 INT243634 Twist1 Regulation of Socs1 1 0.14 0.13 0.31
48 INT253073 Il4 Positive_regulation of Hand2 1 0.10 0.59 0.31
49 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3
50 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3
51 INT243625 Stat4 Positive_regulation of Gene_expression of Twist1 1 0.39 0.75 0.3
52 INT243630 Il12a Positive_regulation of Gene_expression of Twist1 1 0.18 0.69 0.3
53 INT93988 Rab8a Regulation of Hand2 1 0.09 0.78 0.3
54 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
55 INT181442 Ccl2 Positive_regulation of Localization of Hand2 1 0.26 0.63 0.29
56 INT75056 Binding of MC1R and Msx1 1 0.00 0.17 0.29
57 INT191501 NLRP3 Positive_regulation of ECE1 1 0.01 1.09 0.28
58 INT185076 Bpifa2 Positive_regulation of Hand2 1 0.16 0.36 0.28
59 INT278209 Ciita Regulation of Hand2 1 0.36 1.53 0.28
60 INT194821 MAPK1 Regulation of Hand2 1 0.03 1.27 0.28
61 INT162599 Wnt5a Regulation of Gene_expression of IL4I1 1 0.00 0.1 0.28
62 INT191495 NLRP3 Positive_regulation of Protein_catabolism of ECE1 1 0.01 1.09 0.28
63 INT278216 Ciita Regulation of Gene_expression of Hand2 1 0.36 1.53 0.28
64 INT246442 Hand2 Positive_regulation of Gene_expression of Cd79a 1 0.03 0.78 0.27
65 INT305849 Polk Positive_regulation of Gene_expression of Hand2 1 0.08 0.76 0.27
66 INT121830 Binding of Scgb1d2 and Lnp 1 0.02 0.33 0.26
67 INT226537 Hand2 Positive_regulation of IL22 1 0.02 0.86 0.26
68 INT317773 Positive_regulation of GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
69 INT317775 GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
70 INT317771 GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
71 INT168203 Binding of Mc1r and Msx1 1 0.19 0.64 0.25
72 INT275092 Twist1 Regulation of stm 1 0.00 0 0.25
73 INT317776 Positive_regulation of GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
74 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
75 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
76 INT333892 TNF Positive_regulation of Gene_expression of HDAC1 1 0.09 0.46 0.23
77 INT173358 Gnaq Positive_regulation of SMPD1 1 0.01 0.13 0.23
78 INT283948 SALL1 Positive_regulation of Positive_regulation of Ptgfrn 1 0.00 0.21 0.22
79 INT104834 Binding of GLI2 and IGKV2OR2-1 1 0.00 0 0.22
80 INT173357 Gnaq Positive_regulation of PRKCA 1 0.01 0 0.22
81 INT335888 Lrp5 Negative_regulation of Gene_expression of Tph1 1 0.22 0.15 0.21
82 INT72019 Binding of Gnaq and Ptprg 1 0.01 0 0.21
83 INT195212 Binding of CCR4 and Hand2 1 0.03 0.46 0.21
84 INT75057 Binding of POMC and Msx1 2 0.39 0.6 0.2
85 INT226511 Gene_expression of Il25 Positive_regulation of Gene_expression of Hand2 1 0.01 0.95 0.2
86 INT226514 BTPs Negative_regulation of Gene_expression of Hand2 1 0.03 0.22 0.2
87 INT338767 Positive_regulation of Binding of Hand1 and Hand2 1 0.07 0.5 0.2
88 INT226510 BTPs Negative_regulation of Hand2 1 0.03 0.22 0.2
89 INT175464 Hand2 Positive_regulation of Gene_expression of Sftpd 1 0.19 1.05 0.2
90 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
91 INT228737 Rae1 Negative_regulation of Hand2 1 0.08 1.07 0.19
92 INT303937 Positive_regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
93 INT303940 Regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
94 INT316748 IL18 Positive_regulation of Regulation of Hand2 1 0.14 1.11 0.18
95 INT329843 Il4 Regulation of Hand2 1 0.04 0.87 0.18
96 INT303938 Binding of GLI2 and CCL5 1 0.01 0 0.18
97 INT181457 Binding of CCL16 and Hand2 1 0.04 0.92 0.17
98 INT119265 Binding of CREBBP and PPM1E 1 0.01 0.46 0.17
99 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16
100 INT303939 TRAP Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
101 INT219601 Pde4a Negative_regulation of Twist1 1 0.10 0 0.16
102 INT303941 CCL2 Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
103 INT219598 Pde4a Negative_regulation of Gene_expression of Twist1 1 0.10 0 0.16
104 INT104837 IGKV2OR2-1 Negative_regulation of GLI2 1 0.00 0 0.15
105 INT294766 Cerk Regulation of Gene_expression of Hand2 1 0.13 0.32 0.15
106 INT208458 TWIST1 Positive_regulation of Localization of Bdnf 1 0.01 0.19 0.15
107 INT97547 KITLG Negative_regulation of Msx1 1 0.00 0.08 0.15
108 INT97542 Pomc Negative_regulation of Msx1 1 0.13 0.07 0.15
109 INT97545 Gtf3a Negative_regulation of Msx1 1 0.02 0.08 0.15
110 INT161797 Binding of ECE1 and ING1 1 0.01 0.68 0.14
111 INT324898 Ece1 Regulation of Gene_expression of Edn1 1 0.17 0.8 0.14
112 INT347012 Hand2 Positive_regulation of Il4 1 0.01 0 0.14
113 INT161795 Positive_regulation of Binding of ECE1 and ING1 1 0.02 0.68 0.14
114 INT161799 Positive_regulation of Binding of ECE1 and EDN1 1 0.07 0.68 0.14
115 INT347015 Hand2 Regulation of Cd86 1 0.06 0 0.14
116 INT294764 Binding of Hand2 and Cerk 1 0.17 0.31 0.14
117 INT235546 Stat6 Positive_regulation of Positive_regulation of Hand2 1 0.02 0.9 0.14
118 INT347018 Cd80 Regulation of Hand2 1 0.03 0.05 0.13
119 INT323430 Binding of Vhl and Osr1 1 0.02 0.78 0.13
120 INT347007 Cd86 Regulation of Hand2 1 0.06 0.05 0.13
121 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
122 INT301414 Binding of Enpp2 and Twist1 1 0.08 1.26 0.13
123 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13
124 INT323434 Osr1 Regulation of Hif1a 1 0.01 0.79 0.13
125 INT323435 Binding of Osr1 and Gtf3a 1 0.00 0.78 0.13
126 INT323433 Osr1 Regulation of Protein_catabolism of Hif1a 1 0.01 0.8 0.13
127 INT287878 Binding of CREB1 and CREBBP 2 0.01 0.16 0.12
128 INT200326 Hdac1 Negative_regulation of Lhcgr 1 0.03 0 0.12
129 INT200304 Hdac2 Negative_regulation of Rorb 1 0.00 0 0.12
130 INT296080 TGFB1 Regulation of Hand2 1 0.01 1 0.12
131 INT294760 Cerk Positive_regulation of Hand2 1 0.23 0.16 0.12
132 INT214150 Binding of Mc3r and Msx1 1 0.03 0.5 0.12
133 INT200318 Hdac1 Negative_regulation of Transcription of Lhcgr 1 0.03 0 0.12
134 INT200346 Hdac2 Negative_regulation of Lhcgr 1 0.04 0 0.12
135 INT200306 Hdac1 Negative_regulation of Rorb 1 0.00 0 0.12
136 INT200332 Binding of Rcor2 and Hdac1 1 0.15 0.3 0.12
137 INT243642 Binding of Nfatc1 and Twist1 1 0.08 0.23 0.12
138 INT253077 Prok2 Regulation of Gene_expression of Hand2 1 0.10 0.11 0.12
139 INT200347 Hdac2 Negative_regulation of Transcription of Lhcgr 1 0.04 0 0.12
140 INT294758 Regulation of Cerk Positive_regulation of Hand2 1 0.21 0.16 0.12
141 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
142 INT228746 Hspa9 Negative_regulation of Positive_regulation of Hand2 1 0.11 0.31 0.11
143 INT158141 Binding of HOXD13 and SNCA 1 0.54 0.41 0.11
144 INT228760 Rae1 Negative_regulation of Positive_regulation of Hand2 1 0.08 0.31 0.11
145 INT175463 Sftpd Negative_regulation of Gene_expression of Hand2 1 0.17 0.96 0.11
146 INT214152 Binding of Mc4r and Msx1 1 0.03 0.24 0.11
147 INT302287 Twist1 Positive_regulation of Positive_regulation of PTGER2 1 0.03 1.16 0.1
148 INT302288 Twist1 Positive_regulation of PTGER2 1 0.03 1.16 0.1
149 INT233510 Wnt5a Positive_regulation of Gene_expression of Il12a 1 0.03 0.33 0.1
150 INT263495 Hand1 Regulation of Localization of Hand2 1 0.12 0.5 0.09
151 INT263496 Hand2 Regulation of Localization of Hand1 1 0.12 0.5 0.09
152 INT214168 Msx1 Positive_regulation of Gene_expression of DST 1 0.00 0.13 0.09
153 INT201349 Binding of Hand2 and Il4 1 0.17 0.67 0.09
154 INT211960 Wnt5a Positive_regulation of Car2 1 0.13 0.38 0.08
155 INT340505 Binding of Twist1 and Mgat4b 1 0.01 0.45 0.08
156 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
157 INT350909 Binding of Pcsk4 and Twist1 1 0.02 1.91 0.08
158 INT288374 Binding of MLANA and Msx1 1 0.09 0 0.08
159 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08
160 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
161 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08
162 INT268679 Binding of HDAC1 and NCOR2 3 0.17 2.8 0.07
163 INT331790 Binding of gr and Hdac2 1 0.01 0.74 0.07
164 INT331791 Akt1 Negative_regulation of Hdac2 1 0.03 0.8 0.07
165 INT335890 Binding of Dkk1 and Lrp4 1 0.37 0.64 0.07
166 INT331798 Regulation of Binding of gr and Hdac2 1 0.02 0.75 0.07
167 INT335886 Binding of Sost and Lrp4 1 0.28 0.65 0.07
168 INT273372 IL6 Regulation of Regulation of TWIST1 1 0.10 0.1 0.07
169 INT286298 Binding of Hand2 and Negative_regulation of Gene_expression of Il12a 1 0.07 0.3 0.07
170 INT273366 IL6 Regulation of TWIST1 1 0.06 0.1 0.07
171 INT84751 Binding of HRAS and TWIST1 1 0.29 2.6 0.07
172 INT324896 Ece1 Positive_regulation of Negative_regulation of Edn1 1 0.19 0.42 0.07
173 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
174 INT119268 CDKN1A Regulation of CREBBP 1 0.21 0.44 0.07
175 INT268678 Binding of HDAC2 and NCOR2 1 0.18 2.67 0.07
176 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
177 INT312636 Negative_regulation of Binding of Musk and Lrp4 1 0.21 0.32 0.06
178 INT349886 Negative_regulation of Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
179 INT312639 Binding of Musk and Lrp4 1 0.23 0.91 0.06
180 INT262214 Binding of Msx2 and Nr1i2 1 0.19 0.55 0.06
181 INT243637 Il12a Positive_regulation of Transcription of Twist1 1 0.18 0.12 0.06
182 INT312632 Binding of Agrn and Lrp4 1 0.17 0.32 0.06
183 INT227593 Gnaq Negative_regulation of GLUL 1 0.01 0 0.06
184 INT349887 Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
185 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06
186 INT278454 CSF2 Regulation of Hand2 1 0.02 0.66 0.05
187 INT273353 Pde4d Regulation of Gene_expression of Twist1 1 0.26 0.25 0.05
188 INT214146 Msx1 Positive_regulation of Gene_expression of Nucb2 1 0.05 0.19 0.05
189 INT278208 Ciita Negative_regulation of Gene_expression of Hand2 1 0.34 0.7 0.05
190 INT343538 TGFB1 Positive_regulation of Gene_expression of GLI2 1 0.08 0.2 0.05
191 INT243633 Il23a Positive_regulation of Gene_expression of Twist1 1 0.14 0.11 0.05
192 INT210261 Bmp4 Regulation of Gene_expression of Tff3 1 0.64 0 0.05
193 INT268676 Binding of HDAC1 and BCOR 1 0.01 1.31 0.04
194 INT347020 Hand2 Regulation of Gene_expression of Cd86 1 0.08 0.19 0.04
195 INT233849 Twist1 Positive_regulation of Snai2 1 0.07 0.58 0.04
196 INT233852 Twist1 Positive_regulation of Snai1 1 0.02 0.58 0.04
197 INT275090 Twist1 Positive_regulation of Gene_expression of Pde5a 1 0.02 0.62 0.04
198 INT347009 Hand2 Regulation of Gene_expression of Il4 1 0.01 0.19 0.04
199 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
200 INT233851 Twist1 Positive_regulation of Zeb1 1 0.06 0.58 0.04

Single Events

The table below shows the top 100 pain related interactions that have been reported for embryonic digit morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported in embryonic digit morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05
2 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34
3 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22
4 INT112017 Regulation of Hand2 77 0.36 62.23 18.04
5 INT173505 Localization of Hand2 63 0.57 45.32 13.66
6 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32
7 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28
8 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24
9 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47
10 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37
11 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01
12 INT333909 Positive_regulation of Gene_expression of HDAC1 1 0.44 14.15 5.9
13 INT72000 Gene_expression of Gnaq 17 0.75 3.12 5.48
14 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41
15 INT94028 Regulation of Twist1 37 0.44 22.41 5.33
16 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93
17 INT94466 Regulation of Gene_expression of Hand2 14 0.28 7.97 4.46
18 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99
19 INT156131 Binding of Hand2 14 0.25 10.35 3.99
20 INT270065 Positive_regulation of HOXD12 1 0.05 1.11 3.86
21 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4
22 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
23 INT116540 Binding of Twist1 35 0.48 16.32 2.85
24 INT224826 Gene_expression of SALL1 1 0.55 1.94 2.57
25 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48
26 INT32920 Gene_expression of Msx1 19 0.71 4.24 2.42
27 INT55090 Positive_regulation of Wnt7a 13 0.37 2.25 2.2
28 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02
29 INT48880 Positive_regulation of TWIST1 15 0.59 8.6 1.98
30 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
31 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
32 INT112880 Positive_regulation of Gnaq 17 0.49 1.97 1.95
33 INT129239 Positive_regulation of Positive_regulation of Hand2 5 0.43 2.81 1.93
34 INT102861 Phosphorylation of Twist1 6 0.70 0.86 1.81
35 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
36 INT158771 Gene_expression of Lnp 3 0.75 2.65 1.76
37 INT128168 Positive_regulation of Gna12 1 0.01 0 1.76
38 INT90926 Positive_regulation of GLI2 12 0.45 4.99 1.74
39 INT37294 Negative_regulation of Ece1 6 0.54 1.27 1.74
40 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
41 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
42 INT110189 Regulation of Gnaq 3 0.02 0.26 1.63
43 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
44 INT180238 Regulation of Gene_expression of Twist1 13 0.61 4.87 1.59
45 INT71999 Negative_regulation of Gene_expression of Gnaq 3 0.41 0.08 1.56
46 INT128170 Gene_expression of Gna12 1 0.01 0 1.54
47 INT272884 Gene_expression of Hdac2 19 0.43 14.55 1.48
48 INT100672 Transcription of Hand2 9 0.42 2.84 1.47
49 INT140245 Binding of Gli3 3 0.36 2.65 1.46
50 INT102860 Positive_regulation of Phosphorylation of Twist1 1 0.35 0.15 1.42
51 INT10873 Localization of Twist1 21 0.74 10.43 1.37
52 INT333914 Transcription of HDAC1 1 0.34 3.04 1.37
53 INT219579 Negative_regulation of Gene_expression of Twist1 12 0.43 9.07 1.36
54 INT92955 Gene_expression of Ece1 5 0.74 2.2 1.36
55 INT92954 Positive_regulation of Gene_expression of Ece1 2 0.48 2.16 1.32
56 INT95270 Regulation of Ece1 1 0.43 2.08 1.3
57 INT104839 Negative_regulation of GLI2 8 0.35 2.7 1.24
58 INT243621 Transcription of Twist1 13 0.71 4.08 1.23
59 INT110188 Regulation of Gene_expression of Gnaq 2 0.25 0.85 1.22
60 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
61 INT175452 Negative_regulation of Positive_regulation of Hand2 4 0.21 3.78 1.21
62 INT138726 Positive_regulation of Gene_expression of Msx1 5 0.53 1.73 1.2
63 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
64 INT272879 Negative_regulation of Hdac2 8 0.37 5.96 1.17
65 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17
66 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
67 INT87233 Gene_expression of ECE1 12 0.65 3.54 1.12
68 INT260447 Binding of HDAC1 8 0.23 4.47 1.12
69 INT68339 Gene_expression of HDAC2 3 0.51 1.71 1.1
70 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
71 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
72 INT333907 Positive_regulation of HDAC1 4 0.32 3.07 1.03
73 INT72002 Negative_regulation of Gnaq 7 0.35 0.2 1.02
74 INT127647 Regulation of Wnt7a 3 0.07 1.28 1.01
75 INT119674 Localization of GLI2 6 0.52 2.84 0.99
76 INT317791 Localization of HDAC2 2 0.50 2.31 0.99
77 INT182322 Negative_regulation of Gene_expression of GLI2 6 0.11 2.37 0.98
78 INT141475 Negative_regulation of Gene_expression of TWIST1 5 0.41 3.94 0.97
79 INT235516 Positive_regulation of Localization of Hand2 4 0.36 3.04 0.97
80 INT226419 Negative_regulation of Localization of Hand2 4 0.30 3.17 0.96
81 INT64173 Regulation of Gene_expression of GLI2 4 0.37 2.89 0.88
82 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
83 INT297531 Negative_regulation of Ece1 5 0.32 5.49 0.87
84 INT289474 Regulation of GLI2 2 0.06 1.08 0.87
85 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
86 INT112014 Negative_regulation of Regulation of Hand2 3 0.34 2.07 0.86
87 INT128171 Positive_regulation of Gene_expression of Gna12 1 0.01 0 0.85
88 INT110187 Regulation of Regulation of Gnaq 1 0.00 0.07 0.82
89 INT224830 Positive_regulation of Gene_expression of SALL1 1 0.41 0.64 0.81
90 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
91 INT270059 Negative_regulation of Gene_expression of HOXD12 1 0.04 0.48 0.77
92 INT200250 Binding of Hdac2 6 0.22 2.97 0.76
93 INT141915 Positive_regulation of Gene_expression of Gnaq 3 0.19 1.31 0.76
94 INT270061 Gene_expression of HOXD12 1 0.06 0.48 0.76
95 INT114956 Gene_expression of CREBBP 5 0.31 1.56 0.75
96 INT284955 Localization of HDAC1 2 0.47 1.71 0.74
97 INT95617 Regulation of Msx1 2 0.56 1.05 0.73
98 INT104840 Binding of GLI2 6 0.08 1.89 0.72
99 INT272883 Positive_regulation of Gene_expression of Hdac2 5 0.30 4.64 0.7
100 INT128169 Regulation of Gene_expression of Gna12 1 0.01 0 0.7
101 INT272886 Negative_regulation of Gene_expression of Hdac2 4 0.23 4.63 0.69
102 INT68560 Regulation of Gli3 3 0.18 1.51 0.68
103 INT268451 Positive_regulation of Gene_expression of ECE1 3 0.49 1.99 0.67
104 INT271488 Negative_regulation of Negative_regulation of Hand2 3 0.18 2.36 0.67
105 INT75043 Binding of Msx1 6 0.35 2.36 0.65
106 INT28958 Negative_regulation of Wnt7a 3 0.45 0.49 0.65
107 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
108 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
109 INT224827 Regulation of SALL1 2 0.37 3.36 0.62
110 INT114955 Positive_regulation of Gene_expression of CREBBP 2 0.23 0.24 0.61
111 INT243616 Positive_regulation of Transcription of Twist1 6 0.69 2.09 0.6
112 INT150075 Positive_regulation of Gene_expression of WNT5A 2 0.67 2.53 0.59
113 INT132588 Positive_regulation of Negative_regulation of Hand2 1 0.03 0.47 0.58
114 INT32921 Positive_regulation of Msx1 4 0.47 0.99 0.57
115 INT127648 Gene_expression of Wnt7a 2 0.13 1.11 0.56
116 INT88705 Localization of Ece1 2 0.22 2.07 0.55
117 INT112881 Positive_regulation of Positive_regulation of Gnaq 2 0.49 0.86 0.54
118 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
119 INT87230 Localization of ECE1 5 0.80 1.51 0.53
120 INT135062 Transcription of Gli3 1 0.05 0 0.52
121 INT272868 Positive_regulation of Hdac2 3 0.27 2.15 0.5
122 INT177842 Negative_regulation of HDAC1 6 0.31 4.65 0.49
123 INT141919 Positive_regulation of Transcription of Gnaq 1 0.21 1.05 0.49
124 INT141912 Negative_regulation of Transcription of Gnaq 1 0.18 1.07 0.49
125 INT141917 Transcription of Gnaq 1 0.29 1.05 0.49
126 INT121828 Binding of Lnp 2 0.47 0.55 0.48
127 INT121829 Negative_regulation of Lnp 1 0.38 0.49 0.48
128 INT329319 Positive_regulation of Transcription of Ece1 1 0.08 2.64 0.48
129 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
130 INT140436 Binding of TWIST1 5 0.39 2.34 0.47
131 INT206484 Localization of Shh 2 0.75 1.14 0.46
132 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
133 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
134 INT247307 Negative_regulation of Msx1 3 0.22 0.11 0.42
135 INT93926 Gene_expression of Ece1 3 0.27 2.31 0.42
136 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
137 INT85854 Binding of SALL1 5 0.36 1.4 0.41
138 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
139 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
140 INT325217 Regulation of Positive_regulation of Hand2 1 0.21 0.32 0.41
141 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
142 INT324886 Transcription of Ece1 2 0.37 1.95 0.4
143 INT194745 Regulation of Regulation of Hand2 1 0.03 0.95 0.39
144 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
145 INT231199 Positive_regulation of Localization of Twist1 3 0.50 1.45 0.38
146 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
147 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
148 INT226424 Negative_regulation of Transcription of Hand2 1 0.08 0.66 0.37
149 INT196927 Binding of Hdac1 9 0.36 2.31 0.36
150 INT333916 Negative_regulation of HDAC2 2 0.18 1.38 0.36
151 INT198170 Positive_regulation of SALL1 4 0.49 1.5 0.32
152 INT272882 Positive_regulation of Binding of Hdac2 2 0.20 1.12 0.32
153 INT61124 Localization of Ece1 1 0.58 0.08 0.32
154 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
155 INT177856 Negative_regulation of Gene_expression of HDAC2 1 0.19 0.12 0.3
156 INT119675 Positive_regulation of Localization of GLI2 1 0.32 0.43 0.3
157 INT196917 Gene_expression of Hdac1 15 0.71 3.66 0.28
158 INT234407 Positive_regulation of Binding of GLI2 2 0.05 1.33 0.28
159 INT226394 Regulation of Phosphorylation of Hand2 1 0.05 0.97 0.28
160 INT191535 Protein_catabolism of ECE1 1 0.07 1.03 0.28
161 INT297804 Regulation of Lrp5 6 0.60 2.31 0.27
162 INT335875 Regulation of Lrp6 1 0.57 0.43 0.27
163 INT254427 Binding of Lrp5 10 0.48 5.43 0.26
164 INT214128 Negative_regulation of Gene_expression of Msx1 3 0.53 1.25 0.26
165 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
166 INT149315 Binding of Gnaq 2 0.04 0 0.26
167 INT164226 Regulation of TBX3 1 0.23 0.57 0.26
168 INT135061 Protein_catabolism of Gli3 1 0.04 0 0.25
169 INT121475 Regulation of Negative_regulation of Twist1 3 0.14 2.43 0.24
170 INT329320 Positive_regulation of Gene_expression of Ece1 1 0.09 1.31 0.24
171 INT151719 Negative_regulation of Positive_regulation of Ctnnb1 1 0.23 1.9 0.24
172 INT100671 Positive_regulation of Transcription of Hand2 2 0.36 0.81 0.23
173 INT335874 Regulation of Lrp4 1 0.18 0 0.23
174 INT324884 Positive_regulation of Ece1 2 0.37 0.86 0.22
175 INT303943 Protein_catabolism of GLI2 2 0.11 0 0.22
176 INT226390 Phosphorylation of Hand2 1 0.14 0.85 0.22
177 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
178 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21
179 INT263492 Positive_regulation of Regulation of Hand2 3 0.19 4.76 0.21
180 INT312604 Gene_expression of Lrp4 2 0.71 1.48 0.21
181 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
182 INT123265 Negative_regulation of SALL1 3 0.18 0.78 0.19
183 INT324882 Regulation of Transcription of Ece1 1 0.24 0.66 0.19
184 INT135060 Negative_regulation of Transcription of Gli3 1 0.03 0 0.19
185 INT254429 Negative_regulation of Lrp5 4 0.57 1.95 0.18
186 INT284888 Regulation of Transcription of Hand2 1 0.16 0.32 0.18
187 INT120085 Negative_regulation of Gene_expression of Bmp4 5 0.55 0.61 0.17
188 INT135054 Negative_regulation of Negative_regulation of Twist1 2 0.42 0.46 0.17
189 INT99392 Negative_regulation of Localization of Ctnnb1 2 0.59 1.43 0.17
190 INT151721 Negative_regulation of Localization of Ctnnb1 1 0.23 0.96 0.17
191 INT334790 Positive_regulation of Lnp 1 0.42 0.1 0.17
192 INT325506 Positive_regulation of Localization of Ctnnb1 1 0.05 0.28 0.17
193 INT335861 Localization of Lrp6 1 0.69 0.54 0.17
194 INT87231 Binding of ECE1 4 0.37 0.47 0.16
195 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
196 INT182321 Positive_regulation of Gene_expression of GLI2 2 0.28 1.32 0.16
197 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
198 INT55089 Positive_regulation of Positive_regulation of Wnt7a 2 0.27 0.06 0.16
199 INT102354 Localization of TWIST1 3 0.75 0.17 0.15
200 INT266991 Regulation of Hdac2 2 0.07 0.74 0.15
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