GO:0042737

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Name drug catabolic process
Categary Process
Go Slim No
Go Link GO:0042737
Unique Molecular Interactions 182
Total Molecular Interactions 222
Total Single Events 2735
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for drug catabolic process. They are ordered first by their pain relevance and then by number of times they were reported for drug catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT92369 Binding of CYP2D6 and RYBP 1 0.25 0.15 1.73
2 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
3 INT123899 Binding of CYP3A4 and UGT2B7 1 0.52 0 1.46
4 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
5 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09
6 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08
7 INT154237 Binding of CYP2D6 and Ugt2b7 1 0.41 0.75 1
8 INT56273 RYBP Negative_regulation of Cyp1a2 1 0.01 0.17 0.9
9 INT136540 Binding of CYP2C9 and Ugt1a6a 1 0.27 0.81 0.86
10 INT56275 RYBP Positive_regulation of Negative_regulation of Cyp1a2 1 0.01 0.17 0.81
11 INT102630 Cyp3a62 Negative_regulation of Cyp1a2 1 0.40 0 0.81
12 INT100783 Binding of CYP2B6 and CYP3A4 2 0.17 2 0.77
13 INT56272 Cyp2e1 Positive_regulation of Cyp1a2 1 0.52 0.17 0.77
14 INT90959 PPIG Regulation of CYP2C9 1 0.43 0 0.75
15 INT88921 Positive_regulation of CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
16 INT88922 CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
17 INT92370 Binding of CYP2B6 and CYP2D6 1 0.21 0 0.73
18 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7
19 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63
20 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62
21 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59
22 INT102671 Cyp1a2 Regulation of RYBP 1 0.00 0 0.58
23 INT102666 Cyp2e1 Regulation of Cyp1a2 1 0.20 0 0.58
24 INT162503 AHR Regulation of CYP1A2 3 0.61 0.18 0.5
25 INT92803 Binding of CYP1A2 and VKORC1 1 0.31 0.12 0.48
26 INT92804 Positive_regulation of Binding of CYP1A2 and VKORC1 1 0.41 0.12 0.48
27 INT123897 Binding of CYP3A4 and SLC35A2 1 0.39 0 0.45
28 INT123898 CYP3A4 Regulation of UGT2B7 1 0.22 0 0.41
29 INT159903 Binding of CYP2C8 and CYP2C9 1 0.42 0.22 0.35
30 INT301665 CYP2C9 Regulation of Binding of Ppara 1 0.26 1.79 0.34
31 INT132984 CYP3A4 Positive_regulation of Gene_expression of PPP4C 1 0.44 0 0.3
32 INT169146 CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
33 INT169145 Regulation of CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
34 INT114230 NR1I2 Positive_regulation of Positive_regulation of CYP2C9 1 0.13 0.61 0.27
35 INT130678 CYP2C9 Regulation of Cyp1a2 1 0.06 0 0.26
36 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26
37 INT130677 CYP2C9 Regulation of Binding of Ugt2b7 1 0.18 0 0.26
38 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26
39 INT162501 NEUROD1 Regulation of CYP1A2 2 0.22 0.09 0.25
40 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25
41 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25
42 INT130663 Cyp1a2 Regulation of Binding of Ugt2b7 1 0.12 0 0.25
43 INT262229 Binding of CYP3A4 and Casr 1 0.03 0.37 0.24
44 INT115729 Binding of CYP3A7 and CYP3A4 1 0.44 0.05 0.23
45 INT351318 Binding of CYP2C19 and Cyp1a2 1 0.01 0.28 0.22
46 INT318039 CDIPT Positive_regulation of CYP3A4 1 0.06 0.06 0.2
47 INT262224 Sfn Negative_regulation of Transcription of CYP3A4 1 0.06 0.58 0.2
48 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18
49 INT330985 CYP2C9 Positive_regulation of Gene_expression of CYP2C19 1 0.34 0 0.18
50 INT151895 Binding of CYP3A4 and GBE1 1 0.01 0.24 0.18
51 INT264101 Binding of CYP2D6 and Bche 1 0.07 0.33 0.18
52 INT104379 Gh1 Regulation of CYP2D6 1 0.07 0 0.17
53 INT85828 CYP3A4 Negative_regulation of CYP2D6 1 0.47 0.06 0.16
54 INT151894 NR1I2 Positive_regulation of CYP3A4 1 0.19 0.23 0.16
55 INT273561 Binding of CYP1A1 and CYP3A4 1 0.02 0.12 0.15
56 INT262231 Sfn Negative_regulation of Gene_expression of CYP3A4 1 0.06 0.26 0.14
57 INT262232 Nr1i2 Positive_regulation of Gene_expression of CYP3A4 1 0.17 0.26 0.14
58 INT343027 Binding of CYP3A4 and Azi1 1 0.02 0.75 0.14
59 INT262228 Nr1i2 Positive_regulation of Transcription of CYP3A4 1 0.17 0.27 0.13
60 INT262226 Positive_regulation of Nr1i2 Positive_regulation of CYP3A4 1 0.17 0.68 0.12
61 INT97082 CYP2D6 Regulation of HAGH 1 0.02 0 0.11
62 INT97081 CYP3A4 Regulation of HAGH 1 0.02 0 0.11
63 INT155221 Binding of CYP3A4 and PNPLA4 1 0.09 0 0.1
64 INT264085 CYP2C19 Regulation of CYP3A4 1 0.02 0 0.09
65 INT160159 Gene_expression of CYP2C9 Positive_regulation of HSP90B2P 1 0.13 0.53 0.09
66 INT264103 Cyp2e1 Regulation of CYP2C9 1 0.04 0 0.09
67 INT264106 Cyp1a2 Regulation of CYP2D6 1 0.06 0 0.09
68 INT162507 Gtf3a Regulation of CYP1A2 1 0.00 0.09 0.09
69 INT264104 Cyp1a2 Regulation of CYP2C9 1 0.04 0 0.09
70 INT264083 CYP2C19 Regulation of CYP2D6 1 0.05 0 0.09
71 INT177296 Binding of CXADR and CYP3A4 1 0.30 0 0.09
72 INT264084 CYP2C19 Regulation of CYP2C9 1 0.03 0 0.09
73 INT264102 Cyp1a2 Regulation of CYP3A4 1 0.03 0 0.09
74 INT264107 Cyp2e1 Regulation of CYP2D6 1 0.05 0 0.09
75 INT264105 Cyp2e1 Regulation of CYP3A4 1 0.02 0 0.09
76 INT99476 Binding of CYP3A4 and ABCB1 2 0.28 0 0.08
77 INT219661 Binding of CYP2D6 and CYP2E1 1 0.30 0.22 0.08
78 INT177265 Binding of CYP3A4 and NR1H4 1 0.03 0 0.08
79 INT168368 Binding of Cyp1a2 and Cyp2e1 1 0.37 0.08 0.07
80 INT22567 Cyp1a2 Positive_regulation of Tcf21 1 0.04 0 0.06
81 INT345925 IL6 Negative_regulation of Gene_expression of CYP1A2 1 0.13 0.18 0.06
82 INT264568 Binding of STS and CYP1A2 1 0.20 0.18 0.06
83 INT339695 Binding of CYP3A4 and TRO 1 0.06 0.57 0.05
84 INT319578 CYP3A4 Regulation of ALPPL2 1 0.00 0.56 0.05
85 INT180373 CYP2A6 Regulation of Cyp2d4 1 0.05 2.01 0.05
86 INT180372 CYP2A6 Regulation of Cyp1a2 1 0.03 2.02 0.05
87 INT177274 Binding of CYP3A4 and TNFRSF25 1 0.19 0 0.04
88 INT177273 Binding of CYP3A4 and FAUP1 1 0.02 0 0.04
89 INT339707 TRO Positive_regulation of CYP3A4 1 0.12 0.97 0.04
90 INT199406 Binding of CYP3A4 and PPIB 1 0.40 0 0.04
91 INT285385 Ass1 Positive_regulation of Transcription of Cyp1a2 1 0.00 0.09 0.03
92 INT294894 CYP3A4 Negative_regulation of CYP2C19 1 0.08 0.13 0
93 INT139719 Binding of CYP2C9 and UGT1A6 1 0.19 0.1 0
94 INT96893 Binding of CYP3A4 and Orm2 1 0.07 0 0
95 INT262225 Binding of CYP3A4 and Nr1i2 1 0.13 0 0
96 INT20322 Binding of CYP1A2 and CYP26A1 1 0.00 0 0
97 INT96894 Binding of CYP3A4 and Orm1 1 0.00 0 0
98 INT223283 Binding of CYP2C9 and VKORC1 1 0.31 0.16 0
99 INT135130 Binding of CYP3A4 and NR1I2 1 0.34 0.31 0
100 INT199717 2610029G23Rik Regulation of CYP2D6 1 0.02 0.44 0
101 INT210417 APOB Negative_regulation of CYP2D6 1 0.01 0 0
102 INT294895 CYP3A4 Negative_regulation of CYP2C9 1 0.09 0.13 0
103 INT177290 GOPC Positive_regulation of CYP3A4 1 0.15 0 0
104 INT20325 Binding of CYP2D6 and CYP21A2 1 0.00 0 0
105 INT20326 Binding of CYP1A2 and CYP21A2 1 0.01 0 0
106 INT339700 CYP2B6 Positive_regulation of CYP3A4 1 0.13 0.3 0
107 INT53286 Binding of CYP1A2 and OPN1LW 1 0.03 0 0
108 INT96892 Negative_regulation of Binding of CYP3A4 and Orm2 1 0.08 0 0
109 INT199719 2610029G23Rik Regulation of CYP3A4 1 0.01 0.45 0
110 INT157283 CYP1A2 Positive_regulation of Gm7100 1 0.00 0 0
111 INT20324 Binding of CYP2D6 and CYP26A1 1 0.00 0 0
112 INT262223 Negative_regulation of Nr1i2 Negative_regulation of Gene_expression of CYP3A4 1 0.21 0.48 0
113 INT96895 Negative_regulation of Binding of CYP3A4 and Orm1 1 0.00 0 0
114 INT135129 NR1I2 Regulation of Transcription of CYP3A4 1 0.58 0.6 0
115 INT95055 Binding of CYP1A2 and TXNRD1 1 0.04 0 0
116 INT169147 Binding of CYP2D6 and CYP3A 1 0.17 0 0
117 INT199801 gr Regulation of CYP2C9 1 0.08 0.63 0
118 INT210416 ITGA4 Negative_regulation of CYP2D6 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for drug catabolic process. They are ordered first by their pain relevance and then by number of times they were reported in drug catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
2 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
3 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53
4 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16
5 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
6 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
7 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22
8 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35
9 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
10 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35
11 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39
12 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31
13 INT71189 Gene_expression of Cyp1a2 24 0.78 11.39 11.12
14 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66
15 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21
16 INT47860 Negative_regulation of Cyp1a2 20 0.57 6.06 10
17 INT68372 Regulation of CYP2C9 28 0.62 5.64 9.53
18 INT66819 Binding of CYP2C9 41 0.48 8.23 8.76
19 INT61599 Positive_regulation of CYP2C9 43 0.69 11.1 8.33
20 INT17867 Positive_regulation of Cyp1a2 39 0.69 2.58 7.57
21 INT57922 Gene_expression of CYP2C9 65 0.78 22.24 7.53
22 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92
23 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92
24 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73
25 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31
26 INT230829 Localization of Cyp2d4 3 0.63 0.61 5.18
27 INT49292 Positive_regulation of Cyp1a2 17 0.69 6.16 4.96
28 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75
29 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73
30 INT114718 Positive_regulation of Gene_expression of CYP3A4 17 0.49 4.69 4.69
31 INT65514 Gene_expression of Cyp1a2 25 0.77 6.12 4.6
32 INT60188 Positive_regulation of Cyp2d4 10 0.70 1.04 4.35
33 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09
34 INT158593 Negative_regulation of Negative_regulation of CYP3A4 5 0.43 1.16 4.01
35 INT71199 Positive_regulation of Gene_expression of Cyp1a2 4 0.69 1.41 3.36
36 INT71195 Transcription of Cyp1a2 6 0.53 2.41 3.24
37 INT100785 Protein_catabolism of CYP3A4 7 1.00 0.76 3.01
38 INT145710 Localization of CYP2C9 9 0.75 1.66 2.89
39 INT90960 Positive_regulation of Gene_expression of CYP2D6 9 0.50 2.06 2.76
40 INT87822 Binding of Cyp1a2 8 0.47 0.84 2.72
41 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71
42 INT126498 Positive_regulation of Negative_regulation of Cyp1a2 2 0.41 1.21 2.64
43 INT113081 Negative_regulation of Gene_expression of Cyp1a2 6 0.58 1.68 2.39
44 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38
45 INT180343 Negative_regulation of Negative_regulation of Cyp2d4 2 0.36 0.49 2.38
46 INT56337 Regulation of Cyp1a2 8 0.27 1.09 2.33
47 INT20332 Positive_regulation of Positive_regulation of CYP1A2 4 0.69 0.68 2.17
48 INT143686 Negative_regulation of Gene_expression of CYP2D6 4 0.58 0.83 2.16
49 INT117898 Positive_regulation of Protein_catabolism of CYP3A4 1 0.67 0 2.08
50 INT149263 Regulation of Negative_regulation of CYP3A4 4 0.44 1 2.03
51 INT53390 Negative_regulation of Positive_regulation of Cyp1a2 2 0.35 0 2.03
52 INT65424 Positive_regulation of Gene_expression of CYP1A2 6 0.70 2.01 2.01
53 INT101410 Negative_regulation of Positive_regulation of CYP2C9 5 0.42 0.23 1.96
54 INT303913 Regulation of Regulation of CYP2D6 2 0.37 1.09 1.48
55 INT144738 Regulation of Gene_expression of CYP2D6 3 0.60 0 1.44
56 INT110551 Negative_regulation of Negative_regulation of CYP2D6 3 0.40 0.25 1.38
57 INT83822 Protein_catabolism of CYP2C9 3 0.46 1.16 1.31
58 INT71281 Positive_regulation of Gene_expression of CYP2C9 13 0.62 5.11 1.3
59 INT117897 Negative_regulation of Protein_catabolism of CYP3A4 1 0.55 0 1.28
60 INT145488 Regulation of Cyp2d4 5 0.45 1.1 1.19
61 INT331001 Positive_regulation of Localization of CYP2D6 1 0.48 0.23 1.18
62 INT331006 Positive_regulation of Localization of CYP2C9 1 0.34 0.13 1.17
63 INT94396 Regulation of Cyp1a2 4 0.60 0.37 1.15
64 INT134955 Positive_regulation of Transcription of Cyp1a2 2 0.38 0.52 1.14
65 INT125541 Transcription of CYP3A4 7 0.69 2.14 1.02
66 INT130996 Positive_regulation of Regulation of CYP2C9 1 0.34 0 1
67 INT79635 Localization of Cyp1a2 2 0.74 0.26 0.97
68 INT130671 Regulation of Gene_expression of Cyp1a2 2 0.43 1.27 0.87
69 INT95537 Transcription of CYP2D6 4 0.68 0.2 0.85
70 INT77927 Negative_regulation of Gene_expression of Cyp1a2 3 0.42 1.23 0.78
71 INT157282 Localization of CYP1A2 5 0.75 0.54 0.76
72 INT17868 Localization of Cyp1a2 3 0.75 0.05 0.75
73 INT94193 Transcription of Cyp1a2 4 0.65 1.29 0.74
74 INT17865 Regulation of Positive_regulation of Cyp1a2 2 0.45 0 0.74
75 INT144390 Positive_regulation of Negative_regulation of CYP2C9 4 0.49 2.03 0.72
76 INT145711 Regulation of Positive_regulation of CYP2C9 1 0.45 0.64 0.71
77 INT331008 Positive_regulation of Localization of CYP1A2 1 0.42 0.06 0.7
78 INT351280 Negative_regulation of Negative_regulation of CYP1A2 1 0.27 0.53 0.69
79 INT71188 Binding of Cyp1a2 5 0.44 0.58 0.68
80 INT331002 Negative_regulation of Localization of CYP2D6 1 0.40 0.17 0.6
81 INT142624 Regulation of Negative_regulation of CYP2D6 1 0.27 0 0.51
82 INT199410 Negative_regulation of Binding of CYP3A4 4 0.43 0.96 0.5
83 INT331000 Regulation of Positive_regulation of CYP2D6 1 0.43 0.3 0.47
84 INT135131 Regulation of Gene_expression of CYP3A4 8 0.59 4.32 0.44
85 INT130669 Regulation of Gene_expression of CYP2C9 2 0.25 0.69 0.44
86 INT199409 Positive_regulation of Negative_regulation of CYP3A4 7 0.50 2.54 0.41
87 INT144386 Positive_regulation of Negative_regulation of CYP2D6 3 0.49 1.01 0.4
88 INT84396 Positive_regulation of Positive_regulation of Cyp1a2 2 0.24 0.22 0.34
89 INT155222 Positive_regulation of Transcription of CYP3A4 2 0.50 0.13 0.34
90 INT273509 Positive_regulation of Gene_expression of Cyp1a2 2 0.14 1.2 0.33
91 INT158581 Negative_regulation of Positive_regulation of CYP3A4 7 0.43 1.83 0.29
92 INT144387 Positive_regulation of Negative_regulation of CYP1A2 2 0.39 0.64 0.28
93 INT160135 Negative_regulation of Binding of CYP2C9 2 0.43 0.05 0.27
94 INT347186 Regulation of Negative_regulation of Cyp2d4 1 0.45 0.21 0.25
95 INT17861 Positive_regulation of Localization of Cyp1a2 2 0.50 0.05 0.21
96 INT137622 Protein_catabolism of CYP2D6 2 0.38 0 0.17
97 INT344065 Negative_regulation of Binding of CYP2D6 1 0.15 0.05 0.17
98 INT344068 Negative_regulation of Binding of CYP1A2 1 0.15 0.05 0.17
99 INT345946 Negative_regulation of Localization of CYP3A4 1 0.09 0.56 0.16
100 INT261231 Negative_regulation of Gene_expression of Cyp2d4 2 0.42 0.36 0.14
101 INT314338 Positive_regulation of Transcription of Cyp1a2 1 0.13 0.38 0.14
102 INT231567 Negative_regulation of Gene_expression of CYP1A2 2 0.36 0.06 0.13
103 INT162937 Regulation of Regulation of CYP1A2 1 0.45 0 0.12
104 INT162936 Regulation of Gene_expression of CYP1A2 1 0.45 0 0.12
105 INT113802 Transcription of Cyp2d4 1 0.69 0 0.11
106 INT137619 Protein_catabolism of Cyp1a2 1 0.33 0 0.11
107 INT100094 Regulation of Positive_regulation of CYP3A4 3 0.45 0.31 0.1
108 INT160162 Negative_regulation of Gene_expression of CYP2C9 2 0.41 0.37 0.09
109 INT135458 Negative_regulation of Negative_regulation of Cyp1a2 1 0.35 0.36 0.09
110 INT262138 Positive_regulation of Regulation of CYP3A4 1 0.15 0.06 0.07
111 INT274055 Protein_catabolism of CYP1A2 1 0.47 0 0.06
112 INT73220 Regulation of Gene_expression of Cyp1a2 1 0.62 1.01 0.06
113 INT180329 Positive_regulation of Binding of Cyp2d4 1 0.33 1.97 0.05
114 INT306772 Positive_regulation of Negative_regulation of Cyp1a2 1 0.08 0.06 0.04
115 INT264053 Positive_regulation of Negative_regulation of Cyp2d4 1 0.25 0.18 0.03
116 INT135158 Transcription of CYP2C9 2 0.62 0.38 0
117 INT123100 Positive_regulation of Positive_regulation of CYP3A4 2 0.54 0 0
118 INT303488 Negative_regulation of Positive_regulation of Cyp1a2 1 0.18 0.96 0
119 INT277007 Negative_regulation of Transcription of CYP3A4 1 0.39 0.34 0
120 INT83244 Regulation of Positive_regulation of CYP1A2 1 0.43 1.18 0
121 INT158582 Negative_regulation of Positive_regulation of CYP1A2 1 0.41 0 0
122 INT330999 Negative_regulation of Positive_regulation of CYP2D6 1 0.40 0 0
123 INT213256 Regulation of Negative_regulation of CYP2C9 1 0.05 0.59 0
124 INT169150 Regulation of Binding of CYP2D6 1 0.41 0 0
125 INT277008 Regulation of Transcription of CYP3A4 1 0.41 0.67 0
126 INT180326 Regulation of Gene_expression of Cyp2d4 1 0.18 0.77 0
127 INT167110 Regulation of Binding of CYP1A2 1 0.45 0 0
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