GO:0042738

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Name exogenous drug catabolic process
Categary Process
Go Slim No
Go Link GO:0042738
Unique Molecular Interactions 334
Total Molecular Interactions 420
Total Single Events 4276
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for exogenous drug catabolic process. They are ordered first by their pain relevance and then by number of times they were reported for exogenous drug catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
2 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
3 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
4 INT129903 Nr1i2 Regulation of Cyp3a11 1 0.64 1.26 1.9
5 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
6 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
7 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
8 INT315284 PRKG1 Positive_regulation of Nos1 1 0.33 0.85 1.56
9 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
10 INT123899 Binding of CYP3A4 and UGT2B7 1 0.52 0 1.46
11 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
12 INT132465 Ltf Positive_regulation of Nos1 1 0.35 0.05 1.24
13 INT69504 Binding of Nos1 and Gatm 1 0.05 0 1.13
14 INT142572 D5Pas1 Negative_regulation of Nos1 2 0.02 0.14 1.11
15 INT317527 Binding of Hint1 and Nos1 1 0.27 0.1 1.11
16 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09
17 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08
18 INT132464 Ltf Negative_regulation of Positive_regulation of Nos1 1 0.33 0 1.03
19 INT119914 Olr1714 Negative_regulation of Nos1 1 0.02 0.47 1.01
20 INT317555 Nos1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
21 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
22 INT317530 Negative_regulation of Binding of Nos1 and Oprm1 1 0.21 0.06 0.9
23 INT56273 RYBP Negative_regulation of Cyp1a2 1 0.01 0.17 0.9
24 INT28194 Nppb Positive_regulation of CYP2B6 1 0.50 0.05 0.88
25 INT136540 Binding of CYP2C9 and Ugt1a6a 1 0.27 0.81 0.86
26 INT120825 Adcyap1 Positive_regulation of Localization of Nos1 1 0.26 0.62 0.85
27 INT155761 Binding of Nos1 and Tjp1 1 0.13 1.01 0.82
28 INT155760 Binding of Nos1 and Dlg4 1 0.13 1.01 0.82
29 INT28185 CYP2B6 Positive_regulation of Positive_regulation of RYBP 1 0.29 0 0.82
30 INT56275 RYBP Positive_regulation of Negative_regulation of Cyp1a2 1 0.01 0.17 0.81
31 INT102630 Cyp3a62 Negative_regulation of Cyp1a2 1 0.40 0 0.81
32 INT92372 CYP2B6 Positive_regulation of Binding of RYBP 1 0.17 0.09 0.81
33 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8
34 INT100783 Binding of CYP2B6 and CYP3A4 2 0.17 2 0.77
35 INT56272 Cyp2e1 Positive_regulation of Cyp1a2 1 0.52 0.17 0.77
36 INT90120 Jun Positive_regulation of Gene_expression of Nos1 1 0.38 0.39 0.76
37 INT28187 CYP2B6 Positive_regulation of RYBP 1 0.31 0.35 0.76
38 INT90117 Jun Regulation of Gene_expression of Nos1 1 0.21 0.39 0.76
39 INT90125 Nfkb1 Regulation of Gene_expression of Nos1 1 0.17 0.39 0.76
40 INT90116 Nfkb1 Positive_regulation of Gene_expression of Nos1 1 0.32 0.39 0.76
41 INT90959 PPIG Regulation of CYP2C9 1 0.43 0 0.75
42 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
43 INT92370 Binding of CYP2B6 and CYP2D6 1 0.21 0 0.73
44 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
45 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7
46 INT106154 Calca Positive_regulation of Nos1 1 0.29 0.2 0.68
47 INT347962 Cpox Negative_regulation of Positive_regulation of Nos1 1 0.02 0.59 0.67
48 INT220032 Nos1 Positive_regulation of Nos3 1 0.32 0.45 0.66
49 INT220035 Nos1 Positive_regulation of Nos2 1 0.29 0.45 0.66
50 INT118824 OPA1 Positive_regulation of Gene_expression of Nos1 2 0.03 0.24 0.65
51 INT78663 Dlst Regulation of Nos1 1 0.19 0.91 0.65
52 INT135471 Binding of CYP2B6 and UGT2B7 1 0.49 0 0.63
53 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63
54 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62
55 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59
56 INT102671 Cyp1a2 Regulation of RYBP 1 0.00 0 0.58
57 INT102666 Cyp2e1 Regulation of Cyp1a2 1 0.20 0 0.58
58 INT142571 Pnoc Positive_regulation of Nos1 1 0.52 0.06 0.57
59 INT73920 Binding of CCNT1 and CYP2B6 1 0.19 0.17 0.56
60 INT335514 NR1I2 Regulation of Gene_expression of ABCB1 1 0.66 2.42 0.54
61 INT123896 CYP2B6 Regulation of UGT2B7 1 0.42 0 0.53
62 INT97425 Prkcg Regulation of Regulation of Nos1 1 0.06 0 0.53
63 INT162503 AHR Regulation of CYP1A2 3 0.61 0.18 0.5
64 INT317537 Oprm1 Positive_regulation of Phosphorylation of Nos1 1 0.16 0 0.5
65 INT121944 Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.78 0.43 0.49
66 INT90121 Nos1 Regulation of Fos 1 0.27 0.25 0.49
67 INT92803 Binding of CYP1A2 and VKORC1 1 0.31 0.12 0.48
68 INT92804 Positive_regulation of Binding of CYP1A2 and VKORC1 1 0.41 0.12 0.48
69 INT92801 Binding of CYP2B6 and GRHPR 1 0.03 0.1 0.47
70 INT257220 Binding of Nos1 and Flvcr2 1 0.00 0.17 0.47
71 INT149690 M1 Negative_regulation of CYP2C8 1 0.19 0.05 0.46
72 INT123897 Binding of CYP3A4 and SLC35A2 1 0.39 0 0.45
73 INT262220 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Abcc2 1 0.14 0.25 0.44
74 INT159349 Zfp956 Negative_regulation of Nos1 1 0.03 0.61 0.43
75 INT115915 AHR Regulation of Gene_expression of CYP2B6 1 0.06 0.36 0.43
76 INT111410 Nos1 Regulation of Vip 1 0.00 0 0.41
77 INT146273 Binding of Nos1 and Rasd1 1 0.34 0.18 0.41
78 INT111409 Nos1 Regulation of Gene_expression of Vip 1 0.01 0 0.41
79 INT123898 CYP3A4 Regulation of UGT2B7 1 0.22 0 0.41
80 INT146272 Binding of Nos1 and Nos1ap 1 0.28 0.2 0.39
81 INT201274 Car2 Regulation of Gene_expression of Nos1 1 0.05 1.15 0.38
82 INT262205 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.33 0.11 0.38
83 INT262153 Binding of Clta and Nr1i2 1 0.05 0.65 0.38
84 INT320591 Ca2 Positive_regulation of Nos1 1 0.07 0.09 0.37
85 INT262182 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp7a1 1 0.23 0.36 0.36
86 INT69468 CYP2B6 Positive_regulation of Localization of CYP3A 1 0.25 0 0.36
87 INT262189 Binding of Nr1i2 and Nr1h4 1 0.14 0.18 0.36
88 INT69469 CYP2E1 Positive_regulation of CYP2B6 1 0.36 0 0.36
89 INT106998 PAR4 Positive_regulation of NR1I2 1 0.22 0.67 0.35
90 INT159903 Binding of CYP2C8 and CYP2C9 1 0.42 0.22 0.35
91 INT105768 Binding of Nos1 and Nqo1 1 0.00 0.26 0.34
92 INT144448 Nqo1 Regulation of Nos1 1 0.11 0.09 0.34
93 INT301665 CYP2C9 Regulation of Binding of Ppara 1 0.26 1.79 0.34
94 INT144450 Regulation of Nqo1 Regulation of Nos1 1 0.11 0.1 0.34
95 INT262218 Nr1h4 Regulation of Nr1i2 1 0.10 0.15 0.34
96 INT78664 Negative_regulation of Nos1 Negative_regulation of Cebpz 1 0.30 0.43 0.32
97 INT132984 CYP3A4 Positive_regulation of Gene_expression of PPP4C 1 0.44 0 0.3
98 INT304497 Mknk1 Positive_regulation of Nos1 1 0.19 0.53 0.3
99 INT304504 Mapk1 Positive_regulation of Nos1 1 0.29 0.93 0.3
100 INT118239 Binding of CCKAR and CYP2B6 1 0.32 0.19 0.29
101 INT262208 Clta Positive_regulation of Nr1i2 1 0.09 0.59 0.29
102 INT317533 Akt1 Positive_regulation of Nos1 1 0.43 0 0.28
103 INT262144 Nr1h4 Positive_regulation of Positive_regulation of Nr1i2 1 0.19 0.19 0.27
104 INT262194 Rhof Positive_regulation of Nr1i2 1 0.15 0.64 0.27
105 INT262164 Positive_regulation of Rhof Positive_regulation of Nr1i2 1 0.11 0.65 0.27
106 INT114230 NR1I2 Positive_regulation of Positive_regulation of CYP2C9 1 0.13 0.61 0.27
107 INT130678 CYP2C9 Regulation of Cyp1a2 1 0.06 0 0.26
108 INT242763 Olr1746 Negative_regulation of Nos1 1 0.02 0.97 0.26
109 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26
110 INT130677 CYP2C9 Regulation of Binding of Ugt2b7 1 0.18 0 0.26
111 INT262329 TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26
112 INT262330 Positive_regulation of TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26
113 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26
114 INT162501 NEUROD1 Regulation of CYP1A2 2 0.22 0.09 0.25
115 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25
116 INT130663 Cyp1a2 Regulation of Binding of Ugt2b7 1 0.12 0 0.25
117 INT262202 Nr1i2 Regulation of Abcc2 1 0.19 0.12 0.25
118 INT262200 Nr1i2 Regulation of Sult2a1 1 0.31 0.12 0.25
119 INT262167 Binding of Nr1i2 and Nr0b2 1 0.15 0.11 0.25
120 INT126227 Hsp90aa1 Positive_regulation of Nos1 1 0.03 0.73 0.25
121 INT328707 Trat1 Negative_regulation of Nos1 1 0.02 2.32 0.24
122 INT262229 Binding of CYP3A4 and Casr 1 0.03 0.37 0.24
123 INT262179 Nr1i2 Regulation of Gene_expression of Nr0b2 1 0.09 0.07 0.24
124 INT257223 Ltp Positive_regulation of Gene_expression of Nos1 1 0.03 0.07 0.24
125 INT53544 Binding of CYP2B6 and HRH1 1 0.28 0 0.23
126 INT201273 Nos2 Regulation of Nos1 1 0.17 0.99 0.23
127 INT115729 Binding of CYP3A7 and CYP3A4 1 0.44 0.05 0.23
128 INT351318 Binding of CYP2C19 and Cyp1a2 1 0.01 0.28 0.22
129 INT159351 Negative_regulation of Binding of Nos1 and Nos2 1 0.27 0.34 0.22
130 INT106993 CEL Positive_regulation of NR1I2 1 0.39 0.39 0.22
131 INT107007 SPG21 Positive_regulation of NR1I2 1 0.39 0.39 0.22
132 INT106991 TPSD1 Positive_regulation of NR1I2 1 0.07 0.39 0.22
133 INT159348 Binding of Nos1 and Nos2 1 0.23 0.29 0.22
134 INT262178 Binding of Nr1i2 and Abcb1b 1 0.07 1.68 0.21
135 INT318039 CDIPT Positive_regulation of CYP3A4 1 0.06 0.06 0.2
136 INT262210 Negative_regulation of Nr1i2 Negative_regulation of Positive_regulation of Cyp3a11 1 0.31 0.4 0.2
137 INT262224 Sfn Negative_regulation of Transcription of CYP3A4 1 0.06 0.58 0.2
138 INT257218 Camk1 Negative_regulation of Nos1 1 0.04 0.09 0.19
139 INT188922 Binding of Pc and Nr1i2 1 0.11 0 0.19
140 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18
141 INT330985 CYP2C9 Positive_regulation of Gene_expression of CYP2C19 1 0.34 0 0.18
142 INT222661 IFNA1 Positive_regulation of Gene_expression of Nos1 1 0.01 0.25 0.18
143 INT151895 Binding of CYP3A4 and GBE1 1 0.01 0.24 0.18
144 INT261631 Binding of CYP2A6 and CYP2B6 1 0.18 0.32 0.18
145 INT326460 NR1I2 Regulation of Cyp4f18 1 0.01 0.72 0.18
146 INT85828 CYP3A4 Negative_regulation of CYP2D6 1 0.47 0.06 0.16
147 INT304503 Map2k1 Positive_regulation of Nos1 1 0.07 0.66 0.16
148 INT151894 NR1I2 Positive_regulation of CYP3A4 1 0.19 0.23 0.16
149 INT71383 Vip Positive_regulation of Nos1 1 0.01 0.09 0.16
150 INT278614 NR1I2 Regulation of Gene_expression of SULT2A1 1 0.11 0.11 0.15
151 INT257230 Binding of CALM1 and Nos1 1 0.00 0 0.15
152 INT273561 Binding of CYP1A1 and CYP3A4 1 0.02 0.12 0.15
153 INT304496 Mknk1 Positive_regulation of Gene_expression of Nos1 1 0.19 0.18 0.15
154 INT78662 Dlst Positive_regulation of Gene_expression of Nos1 1 0.20 0.17 0.14
155 INT262231 Sfn Negative_regulation of Gene_expression of CYP3A4 1 0.06 0.26 0.14
156 INT262232 Nr1i2 Positive_regulation of Gene_expression of CYP3A4 1 0.17 0.26 0.14
157 INT343027 Binding of CYP3A4 and Azi1 1 0.02 0.75 0.14
158 INT281194 Casr Positive_regulation of Positive_regulation of Nr1i2 1 0.27 0 0.13
159 INT262228 Nr1i2 Positive_regulation of Transcription of CYP3A4 1 0.17 0.27 0.13
160 INT106997 PARD3 Positive_regulation of NR1I2 1 0.19 0.28 0.13
161 INT262193 Binding of Nr1i2 and Sfn 1 0.15 0.26 0.13
162 INT107000 PRSS1 Positive_regulation of NR1I2 1 0.08 0.28 0.13
163 INT281193 Nr1i2 Positive_regulation of Positive_regulation of Casr 1 0.27 0 0.13
164 INT125549 Binding of CYP2B6 and FGFR1 1 0.00 0.07 0.13
165 INT107009 PAR1 Positive_regulation of NR1I2 1 0.18 0.28 0.13
166 INT262197 Nr1i2 Positive_regulation of Insig1 2 0.23 0 0.12
167 INT262185 Positive_regulation of Binding of Ncoa1 and Nr1i2 1 0.04 0.56 0.12
168 INT262226 Positive_regulation of Nr1i2 Positive_regulation of CYP3A4 1 0.17 0.68 0.12
169 INT262148 Positive_regulation of Nr1i2 Positive_regulation of Abcb1b 1 0.09 0.69 0.12
170 INT262206 Sfn Negative_regulation of Nr1i2 1 0.17 0.28 0.12
171 INT195896 Egf Positive_regulation of Nos1 1 0.10 0.57 0.12
172 INT97081 CYP3A4 Regulation of HAGH 1 0.02 0 0.11
173 INT262146 Binding of Ncoa1 and Nr1i2 1 0.03 0.56 0.11
174 INT304502 Mknk1 Positive_regulation of Phosphorylation of Nos1 1 0.19 0.16 0.11
175 INT262207 Binding of Nr1i2 and Ep300 1 0.14 1.08 0.11
176 INT155221 Binding of CYP3A4 and PNPLA4 1 0.09 0 0.1
177 INT262141 Edcs1 Positive_regulation of Nr1i2 1 0.02 0 0.1
178 INT339533 VEGFA Positive_regulation of Gene_expression of CYP2C8 1 0.09 0.57 0.09
179 INT264085 CYP2C19 Regulation of CYP3A4 1 0.02 0 0.09
180 INT160159 Gene_expression of CYP2C9 Positive_regulation of HSP90B2P 1 0.13 0.53 0.09
181 INT264103 Cyp2e1 Regulation of CYP2C9 1 0.04 0 0.09
182 INT264106 Cyp1a2 Regulation of CYP2D6 1 0.06 0 0.09
183 INT162507 Gtf3a Regulation of CYP1A2 1 0.00 0.09 0.09
184 INT264104 Cyp1a2 Regulation of CYP2C9 1 0.04 0 0.09
185 INT264083 CYP2C19 Regulation of CYP2D6 1 0.05 0 0.09
186 INT177296 Binding of CXADR and CYP3A4 1 0.30 0 0.09
187 INT262163 Positive_regulation of Binding of Nr1i2 and Plec 1 0.04 0.31 0.09
188 INT264084 CYP2C19 Regulation of CYP2C9 1 0.03 0 0.09
189 INT262142 Edcs1 Regulation of Nr1i2 1 0.01 0 0.09
190 INT264102 Cyp1a2 Regulation of CYP3A4 1 0.03 0 0.09
191 INT301144 Nos1 Regulation of Gene_expression of TNF 1 0.11 0.55 0.09
192 INT264105 Cyp2e1 Regulation of CYP3A4 1 0.02 0 0.09
193 INT262157 Binding of Nr1i2 and Plec 1 0.03 0.3 0.09
194 INT99476 Binding of CYP3A4 and ABCB1 2 0.28 0 0.08
195 INT197644 NR1I2 Negative_regulation of Positive_regulation of CYP3A 1 0.02 0.47 0.08
196 INT197650 NR1I2 Negative_regulation of Positive_regulation of CYP2A 1 0.02 0.47 0.08
197 INT197652 NR1I2 Positive_regulation of Positive_regulation of CYP2A 1 0.02 0.47 0.08
198 INT262216 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Vdr 1 0.29 0.44 0.08
199 INT177265 Binding of CYP3A4 and NR1H4 1 0.03 0 0.08
200 INT262176 Nr1i2 Regulation of Regulation of Casr 1 0.11 0.17 0.07

Single Events

The table below shows the top 100 pain related interactions that have been reported for exogenous drug catabolic process. They are ordered first by their pain relevance and then by number of times they were reported in exogenous drug catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76
2 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71
3 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61
4 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87
5 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64
6 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
7 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05
8 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39
9 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78
10 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27
11 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83
12 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
13 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
14 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6
15 INT74688 Regulation of Nos1 55 0.62 22.16 25.3
16 INT49172 Regulation of Nos1 43 0.52 27.53 23.66
17 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22
18 INT74059 Positive_regulation of Gene_expression of Nos1 55 0.70 11.5 21.39
19 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79
20 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
21 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35
22 INT114025 Transcription of Nos1 20 0.70 16.48 15.63
23 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39
24 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82
25 INT64112 Regulation of Gene_expression of Nos1 22 0.62 21.45 14.76
26 INT80251 Binding of Nos1 21 0.30 8.24 11.31
27 INT71189 Gene_expression of Cyp1a2 24 0.78 11.39 11.12
28 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66
29 INT90114 Regulation of Gene_expression of Nos1 18 0.62 6.38 10.52
30 INT110017 Phosphorylation of Nos1 12 0.60 1.64 10.3
31 INT47860 Negative_regulation of Cyp1a2 20 0.57 6.06 10
32 INT68372 Regulation of CYP2C9 28 0.62 5.64 9.53
33 INT66819 Binding of CYP2C9 41 0.48 8.23 8.76
34 INT121943 Positive_regulation of Nr1i2 64 0.68 19.22 8.39
35 INT61599 Positive_regulation of CYP2C9 43 0.69 11.1 8.33
36 INT84672 Negative_regulation of Positive_regulation of Nos1 12 0.48 3.76 8.27
37 INT114023 Positive_regulation of Transcription of Nos1 7 0.60 5.35 8.06
38 INT71381 Localization of Nos1 33 0.79 11.46 8.05
39 INT17867 Positive_regulation of Cyp1a2 39 0.69 2.58 7.57
40 INT57922 Gene_expression of CYP2C9 65 0.78 22.24 7.53
41 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92
42 INT92741 Positive_regulation of Positive_regulation of Nos1 8 0.47 1.44 6.58
43 INT2039 Regulation of CYP2B6 30 0.60 7.75 6.43
44 INT69499 Binding of Nos1 15 0.36 2.56 6.23
45 INT93658 Transcription of Nos1 16 0.72 6.85 6.16
46 INT129901 Gene_expression of Nr1i2 60 0.73 22.44 6.04
47 INT64111 Negative_regulation of Gene_expression of Nos1 22 0.57 8.96 6.02
48 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92
49 INT257199 Positive_regulation of Phosphorylation of Nos1 2 0.45 0.68 5.78
50 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73
51 INT84673 Localization of Nos1 19 0.80 5.01 5.62
52 INT18772 Positive_regulation of Gene_expression of CYP2B6 14 0.49 2.93 5.4
53 INT65135 Binding of CYP2C19 17 0.48 1.82 5.2
54 INT49292 Positive_regulation of Cyp1a2 17 0.69 6.16 4.96
55 INT110549 Negative_regulation of CYP2C8 15 0.59 0.54 4.78
56 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75
57 INT61245 Positive_regulation of Cyp2b2 9 0.64 0.41 4.7
58 INT114718 Positive_regulation of Gene_expression of CYP3A4 17 0.49 4.69 4.69
59 INT65514 Gene_expression of Cyp1a2 25 0.77 6.12 4.6
60 INT65881 Gene_expression of CYP2C19 21 0.76 1.19 4.57
61 INT89925 Gene_expression of NR1I2 22 0.75 9.63 4.21
62 INT158593 Negative_regulation of Negative_regulation of CYP3A4 5 0.43 1.16 4.01
63 INT121942 Binding of Nr1i2 2 0.45 15.69 3.66
64 INT134875 Phosphorylation of Nos1 5 0.70 1.21 3.44
65 INT71199 Positive_regulation of Gene_expression of Cyp1a2 4 0.69 1.41 3.36
66 INT142568 Negative_regulation of Positive_regulation of Nos1 2 0.37 0.25 3.3
67 INT71195 Transcription of Cyp1a2 6 0.53 2.41 3.24
68 INT107011 Positive_regulation of NR1I2 14 0.49 8.85 3.11
69 INT100785 Protein_catabolism of CYP3A4 7 1.00 0.76 3.01
70 INT145710 Localization of CYP2C9 9 0.75 1.66 2.89
71 INT136982 Positive_regulation of Positive_regulation of Nr1i2 3 0.65 4.66 2.89
72 INT87822 Binding of Cyp1a2 8 0.47 0.84 2.72
73 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71
74 INT49169 Regulation of Negative_regulation of Nos1 3 0.45 4.67 2.7
75 INT126498 Positive_regulation of Negative_regulation of Cyp1a2 2 0.41 1.21 2.64
76 INT108608 Positive_regulation of Positive_regulation of Nos1 8 0.49 1.66 2.58
77 INT62653 Positive_regulation of CYP2C19 8 0.54 1.23 2.41
78 INT101342 Negative_regulation of CYP2A6 11 0.53 3.68 2.39
79 INT113081 Negative_regulation of Gene_expression of Cyp1a2 6 0.58 1.68 2.39
80 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38
81 INT80391 Negative_regulation of Cyp2b2 4 0.54 0.12 2.36
82 INT56337 Regulation of Cyp1a2 8 0.27 1.09 2.33
83 INT129902 Regulation of Nr1i2 16 0.58 6.3 2.31
84 INT144792 Negative_regulation of Transcription of Nos1 2 0.43 1.74 2.27
85 INT125377 Localization of CYP2B6 5 0.78 0.59 2.23
86 INT89701 Binding of CYP2A6 4 0.36 0.92 2.23
87 INT20332 Positive_regulation of Positive_regulation of CYP1A2 4 0.69 0.68 2.17
88 INT110016 Negative_regulation of Phosphorylation of Nos1 3 0.28 0.47 2.16
89 INT121884 Regulation of Binding of Nos1 2 0.33 1.63 2.15
90 INT117898 Positive_regulation of Protein_catabolism of CYP3A4 1 0.67 0 2.08
91 INT149263 Regulation of Negative_regulation of CYP3A4 4 0.44 1 2.03
92 INT53390 Negative_regulation of Positive_regulation of Cyp1a2 2 0.35 0 2.03
93 INT70878 Gene_expression of CYP2A6 17 0.75 4.25 2.02
94 INT65424 Positive_regulation of Gene_expression of CYP1A2 6 0.70 2.01 2.01
95 INT8766 Positive_regulation of Positive_regulation of CYP2B6 5 0.49 3.41 1.97
96 INT101410 Negative_regulation of Positive_regulation of CYP2C9 5 0.42 0.23 1.96
97 INT95797 Positive_regulation of CYP2C8 8 0.50 0.55 1.94
98 INT65880 Gene_expression of CYP2C8 25 0.77 9.49 1.92
99 INT154727 Regulation of Cyp2b2 2 0.25 0 1.76
100 INT113806 Transcription of CYP2B6 7 0.67 1.75 1.73
101 INT64559 Positive_regulation of Negative_regulation of Nos1 2 0.41 1.58 1.68
102 INT97418 Regulation of Regulation of Nos1 2 0.41 0.94 1.68
103 INT53546 Negative_regulation of Binding of CYP2B6 5 0.43 0.24 1.67
104 INT67704 Negative_regulation of Negative_regulation of CYP2B6 3 0.41 1.69 1.66
105 INT262127 Negative_regulation of Gene_expression of Nr1i2 1 0.55 6.92 1.57
106 INT87095 Positive_regulation of Gene_expression of CYP2C19 3 0.48 0 1.5
107 INT4402 Positive_regulation of Binding of CYP2B6 3 0.49 0.33 1.35
108 INT110550 Regulation of CYP2C8 3 0.45 1.59 1.34
109 INT136981 Positive_regulation of Gene_expression of Nr1i2 2 0.65 3.63 1.34
110 INT83822 Protein_catabolism of CYP2C9 3 0.46 1.16 1.31
111 INT115938 Negative_regulation of Negative_regulation of Nos1 2 0.36 0.27 1.31
112 INT71281 Positive_regulation of Gene_expression of CYP2C9 13 0.62 5.11 1.3
113 INT50031 Negative_regulation of Gene_expression of CYP2B6 5 0.57 2.37 1.29
114 INT117897 Negative_regulation of Protein_catabolism of CYP3A4 1 0.55 0 1.28
115 INT331006 Positive_regulation of Localization of CYP2C9 1 0.34 0.13 1.17
116 INT94396 Regulation of Cyp1a2 4 0.60 0.37 1.15
117 INT144393 Negative_regulation of Negative_regulation of Nos1 2 0.32 0.96 1.15
118 INT72558 Regulation of CYP2C19 6 0.54 1.97 1.14
119 INT134955 Positive_regulation of Transcription of Cyp1a2 2 0.38 0.52 1.14
120 INT262114 Negative_regulation of Nr1i2 1 0.55 4.72 1.12
121 INT108609 Regulation of Localization of Nos1 3 0.45 0 1.06
122 INT125541 Transcription of CYP3A4 7 0.69 2.14 1.02
123 INT89847 Positive_regulation of Localization of Nos1 10 0.49 2.45 1.01
124 INT130996 Positive_regulation of Regulation of CYP2C9 1 0.34 0 1
125 INT79635 Localization of Cyp1a2 2 0.74 0.26 0.97
126 INT158439 Transcription of Nr1i2 2 0.23 0.17 0.93
127 INT134879 Negative_regulation of Phosphorylation of Nos1 1 0.50 0.27 0.93
128 INT61241 Gene_expression of Cyp2b2 1 0.56 0 0.92
129 INT283514 Localization of NR1I2 2 0.74 3.15 0.87
130 INT130671 Regulation of Gene_expression of Cyp1a2 2 0.43 1.27 0.87
131 INT157981 Binding of Cyp2b2 1 0.44 0 0.86
132 INT157982 Positive_regulation of Gene_expression of Cyp2b2 1 0.43 0 0.85
133 INT166416 Positive_regulation of Negative_regulation of CYP2B6 1 0.49 0.8 0.83
134 INT130750 Negative_regulation of Localization of CYP2B6 1 0.41 0 0.82
135 INT77927 Negative_regulation of Gene_expression of Cyp1a2 3 0.42 1.23 0.78
136 INT157282 Localization of CYP1A2 5 0.75 0.54 0.76
137 INT17868 Localization of Cyp1a2 3 0.75 0.05 0.75
138 INT93574 Protein_catabolism of CYP2B6 3 0.96 0.16 0.75
139 INT94193 Transcription of Cyp1a2 4 0.65 1.29 0.74
140 INT94550 Negative_regulation of Gene_expression of CYP2C19 2 0.38 0 0.74
141 INT17865 Regulation of Positive_regulation of Cyp1a2 2 0.45 0 0.74
142 INT216258 Positive_regulation of Regulation of Nos1 2 0.40 1.45 0.74
143 INT144390 Positive_regulation of Negative_regulation of CYP2C9 4 0.49 2.03 0.72
144 INT136980 Negative_regulation of Positive_regulation of Nr1i2 1 0.48 0.33 0.72
145 INT145711 Regulation of Positive_regulation of CYP2C9 1 0.45 0.64 0.71
146 INT92547 Regulation of Localization of Nos1 2 0.43 0.61 0.7
147 INT331008 Positive_regulation of Localization of CYP1A2 1 0.42 0.06 0.7
148 INT351280 Negative_regulation of Negative_regulation of CYP1A2 1 0.27 0.53 0.69
149 INT71188 Binding of Cyp1a2 5 0.44 0.58 0.68
150 INT97192 Regulation of Transcription of Nos1 1 0.55 1.94 0.68
151 INT201270 Regulation of Positive_regulation of Nos1 2 0.38 2.27 0.63
152 INT187379 Positive_regulation of Transcription of CYP2B6 1 0.02 0.25 0.63
153 INT149654 Negative_regulation of NR1I2 2 0.41 1.19 0.59
154 INT144447 Regulation of Regulation of Nos1 1 0.43 0.1 0.59
155 INT117903 Positive_regulation of Protein_catabolism of CYP2B6 1 0.49 0 0.56
156 INT112279 Regulation of Positive_regulation of Nos1 3 0.39 1.07 0.54
157 INT145099 Regulation of Transcription of Nos1 3 0.44 1.24 0.53
158 INT199410 Negative_regulation of Binding of CYP3A4 4 0.43 0.96 0.5
159 INT92549 Negative_regulation of Localization of Nos1 1 0.37 0.26 0.5
160 INT330997 Regulation of Positive_regulation of CYP2C19 1 0.35 0.3 0.47
161 INT135306 Binding of CYP2C8 10 0.46 4.37 0.46
162 INT206949 Regulation of Nr1i2 3 0.57 2.5 0.45
163 INT135131 Regulation of Gene_expression of CYP3A4 8 0.59 4.32 0.44
164 INT130669 Regulation of Gene_expression of CYP2C9 2 0.25 0.69 0.44
165 INT57326 Regulation of Positive_regulation of CYP2B6 4 0.44 2.08 0.43
166 INT199409 Positive_regulation of Negative_regulation of CYP3A4 7 0.50 2.54 0.41
167 INT104414 Negative_regulation of Transcription of Nos1 1 0.42 0.96 0.38
168 INT262054 Regulation of Gene_expression of Nr1i2 1 0.42 1.45 0.36
169 INT84396 Positive_regulation of Positive_regulation of Cyp1a2 2 0.24 0.22 0.34
170 INT155222 Positive_regulation of Transcription of CYP3A4 2 0.50 0.13 0.34
171 INT273509 Positive_regulation of Gene_expression of Cyp1a2 2 0.14 1.2 0.33
172 INT120670 Negative_regulation of Negative_regulation of CYP2C8 1 0.43 0 0.31
173 INT120669 Negative_regulation of Positive_regulation of CYP2C8 1 0.43 0 0.31
174 INT135133 Binding of NR1I2 7 0.42 1.7 0.29
175 INT158581 Negative_regulation of Positive_regulation of CYP3A4 7 0.43 1.83 0.29
176 INT120320 Positive_regulation of Transcription of Nos1 3 0.46 0.58 0.29
177 INT144387 Positive_regulation of Negative_regulation of CYP1A2 2 0.39 0.64 0.28
178 INT107757 Regulation of Negative_regulation of Nos1 2 0.39 0 0.27
179 INT160135 Negative_regulation of Binding of CYP2C9 2 0.43 0.05 0.27
180 INT262086 Negative_regulation of Binding of Nr1i2 1 0.40 0.62 0.27
181 INT238516 Regulation of Regulation of CYP2B6 1 0.05 0.73 0.27
182 INT112278 Positive_regulation of Regulation of Nos1 4 0.38 0.99 0.25
183 INT166936 Positive_regulation of Gene_expression of NR1I2 2 0.43 0.22 0.25
184 INT105900 Regulation of Binding of Nos1 1 0.35 0.52 0.22
185 INT17861 Positive_regulation of Localization of Cyp1a2 2 0.50 0.05 0.21
186 INT206952 Positive_regulation of Nr1i2 2 0.43 0.88 0.21
187 INT133634 Positive_regulation of Negative_regulation of Nos1 1 0.47 0.57 0.2
188 INT85595 Positive_regulation of CYP2A6 5 0.67 1.02 0.17
189 INT144389 Positive_regulation of Negative_regulation of CYP2C19 2 0.43 0.37 0.17
190 INT222905 Regulation of CYP2A6 2 0.32 0.8 0.17
191 INT344067 Negative_regulation of Binding of CYP2A6 1 0.19 0.05 0.17
192 INT257203 Regulation of Phosphorylation of Nos1 1 0.15 0 0.17
193 INT344068 Negative_regulation of Binding of CYP1A2 1 0.15 0.05 0.17
194 INT85594 Regulation of Gene_expression of CYP2C19 1 0.24 0.06 0.16
195 INT345946 Negative_regulation of Localization of CYP3A4 1 0.09 0.56 0.16
196 INT314338 Positive_regulation of Transcription of Cyp1a2 1 0.13 0.38 0.14
197 INT262092 Regulation of Binding of Nr1i2 1 0.42 0 0.14
198 INT142509 Regulation of NR1I2 1 0.24 0 0.14
199 INT231567 Negative_regulation of Gene_expression of CYP1A2 2 0.36 0.06 0.13
200 INT262094 Regulation of Positive_regulation of Nr1i2 2 0.42 0.52 0.13
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