GO:0042745

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Name circadian sleep/wake cycle
Categary Process
Go Slim No
Go Link GO:0042745
Unique Molecular Interactions 47
Total Molecular Interactions 69
Total Single Events 1642
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for circadian sleep/wake cycle. They are ordered first by their pain relevance and then by number of times they were reported for circadian sleep/wake cycle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
2 INT335405 Binding of Arntl and Npas2 1 0.28 1.82 1.61
3 INT63939 Vta1 Positive_regulation of Th 1 0.14 0 1.61
4 INT40887 Penk Regulation of Th 1 0.04 0 1.53
5 INT106070 Positive_regulation of Oprl1 Positive_regulation of TH 1 0.13 0.15 1.36
6 INT60989 Ngf Regulation of Th 1 0.17 0 1.34
7 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
8 INT98832 Th Regulation of Dbh 1 0.32 0.53 1.2
9 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17
10 INT141246 Trib3 Regulation of Gene_expression of Th 1 0.02 0.17 1.17
11 INT60990 Bdnf Negative_regulation of Th 1 0.15 0 1.17
12 INT106069 TH Positive_regulation of Th 1 0.07 0.16 1.14
13 INT88446 Uncx Positive_regulation of Th 1 0.13 0 1.1
14 INT31547 Binding of Th and Vip 1 0.31 0 1.08
15 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
16 INT31548 Binding of Th and Dbh 1 0.35 0 0.98
17 INT335403 Binding of Hspg2 and Npas2 1 0.04 0.93 0.82
18 INT63940 Negative_regulation of Vta1 Positive_regulation of Th 1 0.13 0 0.81
19 INT7958 LOC686180 Positive_regulation of Gene_expression of Th 1 0.02 0 0.64
20 INT7957 Calca Positive_regulation of Gene_expression of Th 1 0.39 0 0.47
21 INT121837 Sct Positive_regulation of Th 1 0.23 0.06 0.43
22 INT139487 Oprm1 Positive_regulation of Th 1 0.26 0.1 0.42
23 INT7625 Man2a2 Regulation of Th 1 0.01 0.07 0.4
24 INT31794 Hps6 Positive_regulation of Th 1 0.03 0 0.38
25 INT173476 Th Regulation of Gene_expression of Bcar1 1 0.10 0 0.34
26 INT34855 Negative_regulation of Maoa Negative_regulation of Th 1 0.17 0 0.34
27 INT173478 Th Regulation of Localization of Ins1 1 0.13 0 0.34
28 INT153019 nct Positive_regulation of Transcription of Th 1 0.19 0.61 0.32
29 INT153020 nct Positive_regulation of Gene_expression of Th 1 0.19 0.61 0.32
30 INT55404 Binding of ENG and Th 1 0.02 0 0.3
31 INT314484 TH Positive_regulation of RLS 1 0.01 1.66 0.29
32 INT78484 Binding of DBH and TH 1 0.09 0 0.28
33 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25
34 INT329432 Binding of CCR6 and TH 1 0.00 0.47 0.23
35 INT329431 Binding of CCL20 and TH 1 0.00 0.47 0.23
36 INT61987 Th Regulation of Penk 1 0.46 0 0.2
37 INT88450 Uncx Regulation of Gene_expression of Th 1 0.06 0 0.17
38 INT261456 Sftpd Positive_regulation of Gene_expression of Th 1 0.10 0.77 0.13
39 INT292968 Fto Regulation of Gene_expression of Th 1 0.30 1.11 0
40 INT292970 Fto Regulation of Th 1 0.18 0.48 0
41 INT127058 Vta1 Negative_regulation of Positive_regulation of Th 1 0.33 0 0
42 INT49943 Binding of Th and Pdx1 1 0.02 0.17 0
43 INT300164 Npas2 Positive_regulation of Transcription of Per1 1 0.13 0.23 0
44 INT163744 Binding of Th and Gfra4 1 0.09 0 0
45 INT178982 Binding of Clock and Npas2 1 0.14 0.08 0
46 INT178983 Binding of Npas2 and Arntl2 1 0.02 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for circadian sleep/wake cycle. They are ordered first by their pain relevance and then by number of times they were reported in circadian sleep/wake cycle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4740 Gene_expression of Th 298 0.78 61.27 154.03
2 INT218 Positive_regulation of Th 245 0.70 40.5 120.1
3 INT7327 Regulation of Th 164 0.62 29.67 110.14
4 INT217 Negative_regulation of Th 134 0.59 26.83 62.63
5 INT350 Localization of Th 79 0.80 10.26 41.17
6 INT7326 Transcription of Th 83 0.72 13.5 35.33
7 INT6558 Positive_regulation of Gene_expression of Th 56 0.70 9.64 30.89
8 INT7956 Regulation of Gene_expression of Th 44 0.61 8.26 29.31
9 INT4781 Gene_expression of TH 68 0.73 26.92 24.01
10 INT26719 Negative_regulation of Gene_expression of Th 38 0.58 11.87 22.78
11 INT13643 Phosphorylation of Th 20 0.82 1.9 20.97
12 INT13716 Positive_regulation of TH 33 0.68 19.11 16
13 INT31368 Positive_regulation of Positive_regulation of Th 19 0.51 2.2 12.68
14 INT141 Binding of Th 21 0.48 3.53 11.04
15 INT48496 Regulation of Transcription of Th 16 0.54 2.29 10.02
16 INT26643 Negative_regulation of Positive_regulation of Th 12 0.59 1.26 7.74
17 INT7624 Positive_regulation of Regulation of Th 7 0.50 2.41 7
18 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88
19 INT3506 Localization of TH 12 0.81 0.78 6.66
20 INT7569 Positive_regulation of Transcription of Th 19 0.70 2.6 6.17
21 INT30317 Regulation of TH 14 0.43 7.27 5.38
22 INT7623 Regulation of Regulation of Th 11 0.44 1.31 5.16
23 INT40620 Regulation of Positive_regulation of Th 9 0.45 2.45 4.69
24 INT30165 Positive_regulation of Phosphorylation of Th 8 0.56 0.75 4.22
25 INT77823 Negative_regulation of Negative_regulation of Th 9 0.59 1.56 3.79
26 INT30166 Regulation of Phosphorylation of Th 4 0.50 0.52 3.33
27 INT4782 Positive_regulation of Gene_expression of TH 12 0.47 7.36 2.95
28 INT106066 Negative_regulation of Positive_regulation of TH 1 0.18 0.22 2.6
29 INT106068 Positive_regulation of Positive_regulation of TH 1 0.21 0.22 2.59
30 INT4704 Positive_regulation of Negative_regulation of Th 4 0.50 0.06 2.56
31 INT13644 Negative_regulation of Phosphorylation of Th 2 0.43 0.06 2.51
32 INT15210 Negative_regulation of Transcription of Th 9 0.59 0.47 2.37
33 INT15209 Negative_regulation of Regulation of Th 6 0.51 1.64 2.16
34 INT1834 Positive_regulation of Binding of Th 1 0.46 0 1.91
35 INT314510 Protein_catabolism of TH 1 0.10 3.28 1.86
36 INT3505 Binding of TH 5 0.39 2.6 1.8
37 INT145545 Transcription of TH 3 0.67 1.48 1.64
38 INT128315 Gene_expression of Npas2 3 0.74 0.57 1.39
39 INT128320 Regulation of Gene_expression of Npas2 1 0.43 0.18 1.38
40 INT26760 Negative_regulation of Localization of Th 2 0.40 0.09 1.14
41 INT89670 Negative_regulation of Binding of Th 2 0.43 0.28 1.12
42 INT208792 Negative_regulation of Gene_expression of TH 6 0.35 1.11 0.94
43 INT208789 Negative_regulation of Localization of TH 2 0.25 0 0.89
44 INT335369 Gene_expression of Npas2 1 0.54 0.92 0.86
45 INT335378 Negative_regulation of Gene_expression of Npas2 1 0.40 0.92 0.86
46 INT53309 Regulation of Localization of Th 1 0.39 0 0.84
47 INT122934 Negative_regulation of Regulation of TH 1 0.03 0.56 0.63
48 INT13929 Protein_catabolism of Th 3 1.00 0 0.58
49 INT314505 Positive_regulation of Protein_catabolism of TH 1 0.05 1.07 0.56
50 INT314499 Negative_regulation of Protein_catabolism of TH 1 0.04 1.06 0.54
51 INT111304 Regulation of Gene_expression of TH 2 0.17 0.57 0.44
52 INT314511 Positive_regulation of Binding of TH 1 0.04 0.68 0.38
53 INT40588 Regulation of Negative_regulation of Th 1 0.16 0.26 0.26
54 INT343976 Negative_regulation of Negative_regulation of TH 1 0.23 0.19 0.23
55 INT237448 Negative_regulation of Binding of TH 1 0.30 0.29 0.22
56 INT140716 Negative_regulation of Protein_catabolism of Th 1 0.59 0 0.19
57 INT140717 Positive_regulation of Protein_catabolism of Th 1 0.47 0 0.19
58 INT314508 Regulation of Positive_regulation of TH 1 0.04 0.92 0.08
59 INT300154 Transcription of Npas2 1 0.23 0.23 0
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