GO:0042769

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Name DNA damage response, detection of DNA damage
Categary Process
Go Slim No
Go Link GO:0042769
Unique Molecular Interactions 56
Total Molecular Interactions 91
Total Single Events 703
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for DNA damage response, detection of DNA damage. They are ordered first by their pain relevance and then by number of times they were reported for DNA damage response, detection of DNA damage. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
2 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
3 INT149684 Negative_regulation of Parp1 Positive_regulation of Oprm1 1 0.51 0 0.65
4 INT149681 Parp1 Regulation of Transcription of Oprm1 1 0.67 0 0.63
5 INT149682 Parp1 Negative_regulation of Oprm1 1 0.47 0 0.6
6 INT149683 Parp1 Negative_regulation of Transcription of Oprm1 1 0.47 0 0.58
7 INT155921 PARP1 Positive_regulation of Gene_expression of IL6 1 0.49 0.44 0.48
8 INT237919 BAX Positive_regulation of Protein_catabolism of PARP1 1 0.03 1.41 0.26
9 INT237925 BCL2 Positive_regulation of Protein_catabolism of PARP1 1 0.02 1.42 0.26
10 INT341378 Positive_regulation of Ros1 Positive_regulation of Parp1 1 0.01 1.08 0.22
11 INT81159 Binding of PARP1 and IgG-2a 1 0.00 1.02 0.21
12 INT287693 Parp1 Positive_regulation of Positive_regulation of Nfkb1 1 0.07 0.54 0.2
13 INT336503 Parp1 Positive_regulation of Tubgcp2 1 0.11 0.52 0.13
14 INT336504 Parp1 Positive_regulation of Mcpt3 1 0.11 0.52 0.13
15 INT336506 Parp1 Positive_regulation of Cxcl2 1 0.16 0.52 0.13
16 INT336505 Parp1 Positive_regulation of Mcpt1 1 0.14 0.52 0.13
17 INT344254 Binding of PARP1 and CASP3 1 0.06 0.94 0.06
18 INT253193 Ros1 Regulation of Parp1 1 0.01 0.57 0.05
19 INT170328 Gene_expression of Ido1 Positive_regulation of Hmga2 1 0.01 0.13 0.04
20 INT322358 Binding of Parp1 and Casp3 1 0.05 1.08 0.04
21 INT261962 Binding of Parp1 and El4 1 0.19 1.33 0.03
22 INT250796 Tlr4 Positive_regulation of Parp1 1 0.14 1 0.03
23 INT225479 Binding of Parp1 and Acsl1 1 0.00 0 0
24 INT196948 Hmga2 Positive_regulation of Hdac1 1 0.36 0.23 0
25 INT207817 Negative_regulation of Parp1 Positive_regulation of Atm 1 0.53 0.2 0
26 INT207815 Parp1 Negative_regulation of Phosphorylation of Atm 1 0.42 0.15 0
27 INT207816 Parp1 Regulation of Positive_regulation of Atm 1 0.51 0.21 0
28 INT155920 PARP1 Regulation of Gene_expression of IL6 1 0.19 0.08 0
29 INT308927 Gtf2i Positive_regulation of Gene_expression of Parp1 1 0.24 0 0
30 INT196959 Hmga2 Positive_regulation of Localization of E2f1 1 0.54 0.24 0
31 INT155926 PARP1 Regulation of Binding of NFKB1 1 0.24 0.16 0
32 INT196940 Positive_regulation of Hmga2 Positive_regulation of E2f1 1 0.50 0.47 0
33 INT325375 Binding of Tp53 and Positive_regulation of Positive_regulation of PARP1 1 0.05 0.59 0
34 INT155916 PARP1 Positive_regulation of Gene_expression of TNF 1 0.42 0 0
35 INT155923 Negative_regulation of PARP1 Negative_regulation of Gene_expression of TNF 1 0.36 0.07 0
36 INT196961 Binding of Hmga2 and Rb1 1 0.48 6.47 0
37 INT225614 Binding of XRCC5 and Parp1 1 0.09 0 0
38 INT341377 Gene_expression of Ros1 Positive_regulation of Parp1 1 0.01 1.03 0
39 INT217151 Gene_expression of MIR98 Negative_regulation of HMGA2 1 0.24 1.08 0
40 INT233020 SFTPA1 Negative_regulation of Parp1 1 0.00 0.58 0
41 INT155919 Gene_expression of PARP1 Positive_regulation of Gene_expression of IL6 1 0.33 0 0
42 INT268600 Mirlet7a-1 Regulation of HMGA2 1 0.01 0.72 0
43 INT196956 Binding of Hmga2 and Hdac1 1 0.25 0.23 0
44 INT322363 TNF Positive_regulation of Positive_regulation of Parp1 1 0.02 1.54 0
45 INT196947 Binding of Rb1 and Positive_regulation of Hmga2 1 0.50 0.3 0
46 INT155922 PARP1 Positive_regulation of Binding of NFKB1 1 0.42 0.06 0
47 INT155924 Binding of PARP1 and NFKB1 1 0.34 0.23 0
48 INT196951 Hmga2 Positive_regulation of E2f1 1 0.50 0.98 0
49 INT207813 Atm Regulation of Gene_expression of Parp1 1 0.44 0.31 0
50 INT196942 Binding of E2f1 and Hmga2 1 0.39 0.87 0
51 INT217142 MIR98 Regulation of Gene_expression of HMGA2 1 0.40 2.22 0
52 INT196953 Hmga2 Negative_regulation of Rb1 1 0.59 0.35 0
53 INT207814 Negative_regulation of Parp1 Positive_regulation of Positive_regulation of Atm 1 0.53 0.08 0
54 INT155925 PARP1 Positive_regulation of NFKB1 1 0.42 0.06 0
55 INT207812 Binding of Parp1 and Atm 1 0.54 0.99 0
56 INT235169 Gene_expression of Dnaja1 Negative_regulation of Binding of Atxn1 1 0.09 0.47 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for DNA damage response, detection of DNA damage. They are ordered first by their pain relevance and then by number of times they were reported in DNA damage response, detection of DNA damage. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49866 Negative_regulation of Parp1 53 0.58 35.37 8.84
2 INT113845 Protein_catabolism of PARP1 54 0.88 43.86 8.77
3 INT123813 Positive_regulation of Parp1 74 0.70 65.36 8.56
4 INT126583 Positive_regulation of PARP1 50 0.68 41.44 7.78
5 INT10992 Gene_expression of PARP1 32 0.76 22.22 3.74
6 INT99348 Negative_regulation of PARP1 38 0.58 30.96 3.36
7 INT155091 Localization of PARP1 15 0.63 13.34 3.15
8 INT34977 Gene_expression of Hmga2 11 0.76 12.39 3.07
9 INT123815 Gene_expression of Parp1 42 0.67 27.82 3.02
10 INT107677 Positive_regulation of Parp1 7 0.45 9.77 3
11 INT107674 Negative_regulation of Parp1 7 0.27 8.91 2.88
12 INT163833 Positive_regulation of Localization of PARP1 7 0.28 7.54 2.14
13 INT155928 Positive_regulation of Gene_expression of PARP1 13 0.68 6.54 2.1
14 INT153800 Positive_regulation of Protein_catabolism of PARP1 18 0.49 16.16 1.89
15 INT10993 Regulation of PARP1 4 0.26 2.04 1.89
16 INT131818 Binding of Parp1 14 0.46 8.74 1.76
17 INT63586 Regulation of Parp1 5 0.43 3.28 1.68
18 INT97053 Transcription of Parp1 3 0.66 2.04 1.43
19 INT175508 Protein_catabolism of Parp1 30 0.85 30 1.09
20 INT123816 Positive_regulation of Gene_expression of Parp1 9 0.50 6.64 1.04
21 INT153125 Negative_regulation of Protein_catabolism of PARP1 8 0.32 6.57 0.98
22 INT34978 Negative_regulation of Gene_expression of Hmga2 2 0.42 1.53 0.95
23 INT147616 Negative_regulation of Positive_regulation of Parp1 3 0.43 2.53 0.84
24 INT157610 Gene_expression of Parp1 4 0.58 2.16 0.77
25 INT88987 Gene_expression of HMGA2 8 0.77 10.46 0.64
26 INT123814 Positive_regulation of Positive_regulation of Parp1 9 0.50 9.32 0.57
27 INT126585 Positive_regulation of Positive_regulation of PARP1 3 0.55 2.84 0.56
28 INT126586 Binding of PARP1 15 0.43 4.96 0.53
29 INT109867 Negative_regulation of Negative_regulation of Parp1 2 0.42 3.37 0.49
30 INT126584 Regulation of Positive_regulation of PARP1 1 0.24 0.78 0.49
31 INT88170 Positive_regulation of HMGA2 2 0.69 2 0.48
32 INT107676 Positive_regulation of Protein_catabolism of Parp1 1 0.10 0.91 0.48
33 INT233013 Positive_regulation of Positive_regulation of Parp1 1 0.23 1.78 0.47
34 INT107675 Negative_regulation of Protein_catabolism of Parp1 1 0.08 0.91 0.47
35 INT107678 Protein_catabolism of Parp1 1 0.19 0.9 0.47
36 INT157609 Regulation of Parp1 2 0.26 1.4 0.43
37 INT10994 Regulation of Gene_expression of PARP1 1 0.01 0.2 0.38
38 INT88167 Negative_regulation of Positive_regulation of HMGA2 1 0.41 0.16 0.35
39 INT186468 Positive_regulation of Protein_catabolism of Parp1 2 0.33 5.05 0.34
40 INT154804 Negative_regulation of Positive_regulation of PARP1 2 0.34 3.88 0.33
41 INT352918 Transcription of PARP1 1 0.25 0.85 0.33
42 INT287690 Negative_regulation of Positive_regulation of Parp1 1 0.20 0.65 0.33
43 INT153126 Negative_regulation of Gene_expression of PARP1 3 0.19 2.09 0.29
44 INT88988 Positive_regulation of Gene_expression of HMGA2 1 0.69 4.05 0.29
45 INT196937 Positive_regulation of Hmga2 3 0.68 2.47 0.28
46 INT169195 Negative_regulation of Localization of PARP1 1 0.27 0.99 0.26
47 INT287683 Regulation of Gene_expression of Parp1 1 0.21 0.64 0.26
48 INT207809 Positive_regulation of Negative_regulation of Parp1 2 0.50 1.01 0.2
49 INT175532 Localization of Parp1 9 0.74 5.73 0.17
50 INT250795 Negative_regulation of Gene_expression of Parp1 4 0.41 5.01 0.15
51 INT199856 Negative_regulation of Protein_catabolism of Parp1 2 0.41 1.46 0.15
52 INT325373 Negative_regulation of Binding of PARP1 1 0.31 0.98 0.15
53 INT253175 Regulation of Positive_regulation of Parp1 2 0.52 0.97 0.08
54 INT170298 Regulation of Gene_expression of Hmga2 1 0.01 0.48 0.08
55 INT175513 Positive_regulation of Localization of Parp1 2 0.23 2.23 0.07
56 INT88990 Binding of HMGA2 1 0.48 0.95 0.07
57 INT170300 Positive_regulation of Gene_expression of Hmga2 2 0.68 4.51 0.06
58 INT170302 Regulation of Hmga2 2 0.44 0.94 0.06
59 INT253176 Regulation of Gene_expression of Parp1 2 0.23 0.61 0.05
60 INT257999 Phosphorylation of PARP1 1 0.12 0.28 0.05
61 INT155929 Positive_regulation of Negative_regulation of PARP1 2 0.49 1.02 0.04
62 INT236481 Negative_regulation of Negative_regulation of PARP1 1 0.15 0.95 0.04
63 INT76371 Protein_catabolism of Hmga2 1 0.02 0.06 0.03
64 INT155927 Positive_regulation of Binding of PARP1 2 0.49 0.32 0
65 INT235153 Negative_regulation of Gene_expression of Dnaja1 1 0.09 0.47 0
66 INT196931 Phosphorylation of Hmga2 1 0.80 0.4 0
67 INT235152 Localization of Dnaja1 1 0.17 0.72 0
68 INT175530 Regulation of Protein_catabolism of Parp1 1 0.09 1.36 0
69 INT196923 Binding of Hmga2 1 0.47 2.5 0
70 INT296561 Positive_regulation of Dnaja1 1 0.43 1.2 0
71 INT300344 Localization of HMGA2 1 0.42 1.75 0
72 INT217195 Negative_regulation of HMGA2 1 0.55 3.54 0
73 INT235143 Gene_expression of Dnaja1 1 0.17 0.47 0
74 INT196932 Negative_regulation of Binding of Hmga2 1 0.42 0.24 0
75 INT196938 Negative_regulation of Hmga2 1 0.42 0.23 0
76 INT235131 Positive_regulation of Gene_expression of Dnaja1 1 0.15 0.47 0
77 INT268581 Regulation of HMGA2 1 0.18 0.72 0
78 INT207802 Regulation of Localization of Parp1 1 0.45 0.35 0
79 INT217225 Negative_regulation of Negative_regulation of HMGA2 1 0.55 2.4 0
80 INT196921 Localization of Hmga2 1 0.74 0.44 0
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