GO:0042771

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Name DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
Categary Process
Go Slim No
Go Link GO:0042771
Unique Molecular Interactions 511
Total Molecular Interactions 614
Total Single Events 4541
Pain Genes Associated 22

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis. They are ordered first by their pain relevance and then by number of times they were reported for DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
3 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
4 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
5 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
6 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
7 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
8 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
9 INT64067 Tp63 Negative_regulation of Localization of Gh1 1 0.08 0.07 0.76
10 INT64070 Tp63 Regulation of Ghrh 1 0.04 0.06 0.69
11 INT64068 Tp63 Regulation of Fdft1 1 0.00 0.06 0.69
12 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
13 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
14 INT141362 EP300 Negative_regulation of Transcription of IL2 1 0.17 0 0.56
15 INT167651 Binding of Oprd1 and Ep300 1 0.02 0.09 0.55
16 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
17 INT167652 Binding of Ep300 and Ngf 1 0.09 0.06 0.51
18 INT167655 Binding of Polr2f and Ep300 1 0.01 0.06 0.51
19 INT278105 Negative_regulation of TP63 Negative_regulation of Binding of P2RX7 1 0.00 0 0.51
20 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
21 INT195552 Binding of Rela and Ep300 1 0.03 0.2 0.45
22 INT195554 Binding of Nfkb1 and Ep300 1 0.08 0.2 0.45
23 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
24 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
25 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
26 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
27 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
28 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
29 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
30 INT166952 LYRM4 Positive_regulation of Gene_expression of TP53 1 0.05 0.75 0.28
31 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
32 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
33 INT302837 Binding of TNFRSF10D and Trp53 1 0.01 0.98 0.28
34 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27
35 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
36 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26
37 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26
38 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26
39 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
40 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
41 INT125516 TP53 Regulation of GDF15 1 0.10 0.47 0.26
42 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
43 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
44 INT156879 Gene_expression of TP53 Negative_regulation of Positive_regulation of PDF 1 0.45 0.9 0.24
45 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
46 INT256656 Binding of EP300 and HHIP 1 0.22 0 0.24
47 INT156881 TP53 Positive_regulation of Positive_regulation of PDF 1 0.49 0.89 0.24
48 INT229177 IFRD1 Regulation of TP53 1 0.13 0.68 0.23
49 INT226902 Padi3 Regulation of Trp53 1 0.06 0.69 0.22
50 INT229178 TP53 Regulation of ICAM1 1 0.07 0.9 0.21
51 INT182606 Binding of MSH2 and MSH3 1 0.12 1.4 0.21
52 INT156882 Binding of TP53 and PDF 1 0.39 0.77 0.21
53 INT156880 TP53 Positive_regulation of Gene_expression of PDF 1 0.49 0.75 0.21
54 INT210887 Sst Positive_regulation of Gene_expression of Trp53 1 0.33 0.93 0.2
55 INT325529 Binding of Stat3 and Ep300 1 0.01 0.22 0.19
56 INT325531 Positive_regulation of Binding of Stat3 and Ep300 1 0.02 0.22 0.19
57 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19
58 INT142853 Binding of TP53 and WISP2 1 0.33 1.43 0.19
59 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
60 INT102804 NFKB1 Regulation of TP53 1 0.35 0.77 0.17
61 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
62 INT102803 NFKB1 Regulation of Gene_expression of TP53 1 0.35 0.77 0.17
63 INT119267 Binding of EP300 and PPM1E 1 0.01 0.46 0.17
64 INT91812 Binding of FASLG and TP53 1 0.04 1.1 0.16
65 INT91811 Binding of FAS and TP53 1 0.21 1.1 0.16
66 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
67 INT266377 Binding of S100a11 and Trp53 1 0.02 0.89 0.15
68 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14
69 INT29207 Msh2 Regulation of POMC 1 0.02 0.1 0.14
70 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
71 INT132148 LTF Positive_regulation of TP53 1 0.44 0.56 0.13
72 INT243308 Binding of LAMP2 and BBC3 1 0.08 0.59 0.13
73 INT243319 Binding of ATP6V0A1 and BBC3 1 0.07 0.59 0.13
74 INT103561 Binding of TP53 and Mc1r 1 0.03 1 0.13
75 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13
76 INT319731 Ep300 Positive_regulation of Binding of Rela 1 0.01 0.37 0.12
77 INT83370 Binding of HRAS and TP53 1 0.30 0.59 0.11
78 INT319727 Binding of Crebbp and Ep300 1 0.02 0.36 0.11
79 INT319728 Positive_regulation of Binding of Crebbp and Ep300 1 0.03 0.36 0.11
80 INT262207 Binding of Nr1i2 and Ep300 1 0.14 1.08 0.11
81 INT266386 Binding of S100a1 and Trp53 1 0.03 0.64 0.1
82 INT193782 Binding of TP53 and SDF2L1 1 0.00 0.67 0.1
83 INT262522 Binding of Trp53 and Foxo4 1 0.05 0.7 0.1
84 INT310743 TP53 Regulation of BAX 1 0.09 1.11 0.1
85 INT326126 Binding of S100A1 and TP53 1 0.04 1.34 0.09
86 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09
87 INT302168 YWHAQ Regulation of TP53 1 0.01 0.41 0.09
88 INT265466 CSPG4 Regulation of Phosphorylation of TP53 1 0.09 0.15 0.09
89 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
90 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
91 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
92 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
93 INT287880 Binding of CREB1 and EP300 1 0.01 0 0.08
94 INT266394 Binding of S100a4 and Trp53 1 0.03 0.59 0.08
95 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
96 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
97 INT266390 Binding of S100a6 and Trp53 1 0.04 0.51 0.07
98 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
99 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
100 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
101 INT245296 Trp53 Regulation of Gadd45a 1 0.05 0.43 0.07
102 INT119266 CDKN1A Regulation of EP300 1 0.47 0.44 0.07
103 INT266398 Binding of S100b and Trp53 1 0.06 0.92 0.07
104 INT302143 TP53 Regulation of Positive_regulation of CASP3 1 0.01 0.69 0.06
105 INT317426 Binding of CSF2 and PML 1 0.08 1.25 0.06
106 INT307223 CYLD Positive_regulation of Localization of BCL3 1 0.12 0.51 0.06
107 INT302155 TP53 Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
108 INT307226 CYLD Negative_regulation of Localization of BCL3 1 0.10 0.45 0.06
109 INT204074 Tp53 Positive_regulation of Cdkn1b 1 0.00 0.59 0.06
110 INT140291 ROS1 Positive_regulation of TP53 1 0.52 1.27 0.06
111 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06
112 INT190044 Binding of Msh2 and Msh6 2 0.32 0.77 0.05
113 INT265459 Phosphorylation of TP53 Positive_regulation of Localization of CASP9 1 0.17 1.16 0.05
114 INT352618 Tpt1 Regulation of Trp53 1 0.06 0.54 0.05
115 INT286768 Binding of Trp53 and Tusc2 1 0.07 1.1 0.05
116 INT352621 Gli1 Negative_regulation of Trp53 1 0.32 0.56 0.05
117 INT181601 Binding of TP53 and WT1 1 0.30 0.9 0.05
118 INT265454 Phosphorylation of TP53 Positive_regulation of CASP9 1 0.17 1.16 0.05
119 INT345181 Gpr87 Regulation of Trp53 1 0.01 0.42 0.05
120 INT193788 ITIH4 Regulation of Phosphorylation of TP53 1 0.07 0.45 0.05
121 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
122 INT190050 Binding of Msh2 and Pms2 2 0.32 0.49 0.04
123 INT352612 Trp53 Negative_regulation of Cd44 1 0.24 1.01 0.04
124 INT348022 Binding of Jun and Trp53 1 0.07 0.46 0.04
125 INT172214 BAX Positive_regulation of TP53 1 0.09 0.37 0.04
126 INT329230 Negative_regulation of ATIC Positive_regulation of Trp53 1 0.00 0.58 0.04
127 INT340394 Binding of Bax and Bbc3 1 0.01 0.36 0.04
128 INT329228 ATIC Positive_regulation of Trp53 1 0.01 0.58 0.04
129 INT352619 Bcl2l12 Negative_regulation of Trp53 1 0.27 0.94 0.04
130 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
131 INT352613 Binding of Trp53 and Bcl2l12 1 0.23 0.94 0.04
132 INT225569 Binding of Ncoa6 and Ep300 1 0.18 0.63 0.04
133 INT170457 RASGRP1 Regulation of TP53 1 0.02 0.58 0.04
134 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
135 INT201726 Mapk8 Positive_regulation of Positive_regulation of Trp53 1 0.00 0.41 0.04
136 INT260267 Binding of TFAM and TP53 2 0.37 2.1 0.03
137 INT355036 CKAP4 Regulation of Positive_regulation of TP53 1 0.08 0.4 0.03
138 INT266903 Binding of Sod2 and Trp53 1 0.05 0 0.03
139 INT211873 TP53 Positive_regulation of Transcription of CD40 1 0.03 1.44 0.03
140 INT234625 TP53 Positive_regulation of IGFBP3 1 0.29 0.74 0.03
141 INT352624 Trp53 Negative_regulation of CEL 1 0.01 1.01 0.03
142 INT265464 CSPG4 Regulation of Gene_expression of TP53 1 0.09 0.23 0.03
143 INT338900 MYC Positive_regulation of Gene_expression of TP73 1 0.05 0.27 0.03
144 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
145 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03
146 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
147 INT229098 Binding of TP53 and IER3 1 0.01 1.47 0.03
148 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
149 INT276389 Binding of Trp53 and KRT20 1 0.01 0.97 0.03
150 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
151 INT172716 Binding of BCL3 and NFKB1 1 0.06 0.15 0.03
152 INT314690 TP53 Regulation of Gene_expression of ZBTB7A 1 0.33 0.97 0.03
153 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
154 INT211872 TP53 Positive_regulation of CD40 1 0.03 1.44 0.03
155 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0
156 INT290556 Binding of MLH1 and MSH2 3 0.34 2.74 0
157 INT234178 Binding of BRCA1 and BRCA2 2 0.40 1.52 0
158 INT180040 Binding of D7Cwr3P and Sirt1 1 0.00 0 0
159 INT348532 TP63 Positive_regulation of CASP3 1 0.04 0.55 0
160 INT313597 Binding of BRCA2 and TOX3 1 0.11 0.7 0
161 INT352615 Binding of Mdm4 and Trp53 1 0.30 1.36 0
162 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
163 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0
164 INT315395 Regulation of Binding of IFNA1 and Tp53 1 0.00 0.46 0
165 INT57107 Binding of Msh2 and Nts 1 0.22 0.22 0
166 INT304020 AR Regulation of TP53 1 0.24 1.11 0
167 INT292882 Binding of S100A12 and TP63 1 0.06 0.51 0
168 INT315221 Tpt1 Regulation of Positive_regulation of Trp53 1 0.33 1.04 0
169 INT203901 HIVEP1 Positive_regulation of Gene_expression of TP53 1 0.04 0.86 0
170 INT225562 Binding of Srcs4 and Ep300 1 0.02 0 0
171 INT235649 TP73 Regulation of EFNA1 1 0.09 0.97 0
172 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0
173 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
174 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0
175 INT232006 Binding of Trp53 and Tsp1 1 0.06 0.75 0
176 INT220456 Binding of VCAN and BAG6 1 0.01 3.46 0
177 INT314742 Binding of RAD51 and Brca2 1 0.06 1.05 0
178 INT333685 Binding of Trp53 and Hdac1 1 0.26 0.55 0
179 INT333688 Trp53 Positive_regulation of Bcl2 1 0.45 2.51 0
180 INT234182 Binding of BRCA2 and PALB2 1 0.41 1.43 0
181 INT304022 Binding of PIK3CG and TP53 1 0.10 0.72 0
182 INT333690 Hr Negative_regulation of Transcription of Trp53 1 0.23 0.51 0
183 INT217776 TP53 Regulation of MITF 1 0.00 1.28 0
184 INT334322 Binding of RB1 and TP53 1 0.34 2 0
185 INT342007 Mta1 Regulation of Trp53 1 0.15 0.15 0
186 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
187 INT179095 Myc Positive_regulation of Gene_expression of Trp53 1 0.43 0.83 0
188 INT315397 Binding of IFNA1 and Tp53 1 0.00 0.43 0
189 INT333689 Hr Positive_regulation of Protein_catabolism of Trp53 1 0.25 1.71 0
190 INT345489 TP53 Positive_regulation of PMAIP1 1 0.05 0.6 0
191 INT286044 Wwox Positive_regulation of Tp53 1 0.05 0.63 0
192 INT347162 MDM2 Negative_regulation of TP53 1 0.02 1.09 0
193 INT287875 EP300 Negative_regulation of HDAC9 1 0.04 0.51 0
194 INT235645 TP53 Regulation of EPHA2 1 0.10 0.97 0
195 INT241256 TP53 Regulation of OPCML 1 0.12 1.31 0
196 INT345485 Binding of MCL1 and BBC3 1 0.01 0.79 0
197 INT305542 Binding of Rb1 and Trp53 1 0.00 0.9 0
198 INT352625 Trp53 Regulation of CEL 1 0.00 0.71 0
199 INT320714 Gene_expression of MDM2 Negative_regulation of TP53 1 0.16 0.88 0
200 INT333455 ATM Positive_regulation of TP53 1 0.18 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis. They are ordered first by their pain relevance and then by number of times they were reported in DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
2 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
3 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
4 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
5 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64
6 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
7 INT152668 Negative_regulation of EP300 13 0.38 7.78 9.03
8 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
9 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
10 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
11 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
12 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
13 INT60585 Regulation of TP53 59 0.59 54.55 5.21
14 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
15 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
16 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
17 INT2213 Regulation of EP300 10 0.54 4.72 4.5
18 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
19 INT41878 Positive_regulation of EP300 13 0.61 5.24 3.95
20 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
21 INT12844 Binding of TP63 15 0.47 10.57 3.38
22 INT8103 Binding of TP53 46 0.44 40.2 2.96
23 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
24 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
25 INT55952 Transcription of TP53 16 0.61 12.14 2.36
26 INT171511 Gene_expression of EP300 14 0.53 4.17 2.29
27 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
28 INT26123 Regulation of Ep300 6 0.23 1.22 2.03
29 INT171514 Binding of EP300 13 0.32 4.32 2.01
30 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
31 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
32 INT26124 Negative_regulation of Ep300 5 0.37 1.25 1.94
33 INT65855 Localization of TP53 18 0.76 17.08 1.89
34 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
35 INT172622 Localization of EP300 8 0.65 2.56 1.72
36 INT86909 Negative_regulation of MSH2 9 0.41 12.65 1.7
37 INT97062 Binding of PML 10 0.41 11.63 1.65
38 INT113985 Positive_regulation of TP63 9 0.50 8.79 1.62
39 INT107992 Gene_expression of MSH2 39 0.78 37.09 1.6
40 INT193823 Positive_regulation of Gene_expression of TP63 7 0.18 7.74 1.57
41 INT64233 Regulation of Trp53 35 0.62 27.11 1.53
42 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
43 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
44 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
45 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
46 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
47 INT172953 Binding of Trp53 33 0.37 20.76 1.41
48 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41
49 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
50 INT145221 Binding of Tp53 10 0.37 8.59 1.37
51 INT74443 Positive_regulation of PML 11 0.53 12.52 1.21
52 INT70821 Positive_regulation of Ep300 4 0.25 1.47 1.2
53 INT174156 Localization of Trp53 16 0.72 13.52 1.18
54 INT116436 Negative_regulation of Phosphorylation of TP53 2 0.40 0.94 1.16
55 INT234422 Gene_expression of PML 14 0.75 15.93 1.14
56 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13
57 INT278117 Negative_regulation of TP63 5 0.32 3.38 1.13
58 INT220465 Binding of BAG6 7 0.30 6.41 1.07
59 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
60 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
61 INT97052 Transcription of Trp53 12 0.64 6.52 1.01
62 INT167650 Binding of Ep300 1 0.09 0.14 1
63 INT93356 Negative_regulation of Gene_expression of Trp53 28 0.53 20.61 0.8
64 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
65 INT147433 Gene_expression of BRCA2 7 0.62 7.02 0.79
66 INT44293 Regulation of TP63 6 0.24 2.88 0.76
67 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75
68 INT92142 Binding of MSH2 5 0.46 5.64 0.75
69 INT168245 Positive_regulation of Transcription of Tp53 2 0.70 2.63 0.75
70 INT162470 Negative_regulation of Protein_catabolism of TP53 1 0.32 1.24 0.74
71 INT74097 Gene_expression of Ep300 6 0.52 1.89 0.73
72 INT262726 Localization of PML 6 0.57 7.13 0.72
73 INT25176 Regulation of Msh2 3 0.37 0.48 0.68
74 INT142696 Positive_regulation of BBC3 3 0.67 1.7 0.67
75 INT93358 Negative_regulation of Positive_regulation of Trp53 9 0.41 3.95 0.6
76 INT53950 Phosphorylation of Tp53 8 0.61 9.4 0.6
77 INT154151 Positive_regulation of TP73 5 0.67 5.71 0.52
78 INT25175 Gene_expression of Msh2 2 0.55 0.4 0.52
79 INT146545 Negative_regulation of Gene_expression of MSH2 17 0.56 18.87 0.51
80 INT286035 Negative_regulation of Gene_expression of Tp53 5 0.32 6.2 0.49
81 INT306741 Positive_regulation of Positive_regulation of TP63 2 0.05 1.16 0.49
82 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
83 INT278121 Negative_regulation of Negative_regulation of TP63 1 0.03 0 0.48
84 INT156734 Gene_expression of BBC3 3 0.58 2.41 0.46
85 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
86 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
87 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
88 INT139976 Regulation of Tp53 7 0.44 6.49 0.39
89 INT145220 Negative_regulation of Binding of Tp53 1 0.20 0.75 0.36
90 INT187587 Binding of Ep300 11 0.35 2.37 0.34
91 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
92 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
93 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
94 INT93355 Negative_regulation of Negative_regulation of Trp53 2 0.41 0.92 0.3
95 INT179089 Protein_catabolism of Trp53 8 0.90 6.52 0.29
96 INT336951 Positive_regulation of Binding of PML 1 0.09 2.02 0.28
97 INT166960 Positive_regulation of Negative_regulation of TP53 2 0.25 1.65 0.26
98 INT289317 Positive_regulation of Localization of PML 1 0.23 1.09 0.26
99 INT173223 Negative_regulation of BRCA2 7 0.54 6.79 0.25
100 INT314729 Regulation of Localization of TP53 1 0.30 2.5 0.25
101 INT154150 Regulation of TP73 3 0.15 2.81 0.24
102 INT228124 Positive_regulation of Bbc3 3 0.49 2.29 0.24
103 INT278513 Regulation of Localization of PML 1 0.34 1.73 0.24
104 INT325492 Regulation of Ep300 1 0.04 0.29 0.24
105 INT179088 Positive_regulation of Regulation of Trp53 3 0.38 3.23 0.23
106 INT156886 Positive_regulation of Localization of TP53 1 0.48 0.87 0.23
107 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
108 INT282970 Gene_expression of Bbc3 2 0.02 2.83 0.2
109 INT212787 Negative_regulation of Binding of EP300 1 0.13 0.53 0.2
110 INT256666 Regulation of Gene_expression of EP300 1 0.14 0.07 0.2
111 INT256661 Regulation of Positive_regulation of EP300 1 0.23 0.07 0.2
112 INT154147 Gene_expression of TP73 7 0.34 3.97 0.19
113 INT19359 Binding of BRCA2 5 0.47 2.63 0.19
114 INT325490 Positive_regulation of Ep300 1 0.03 0.22 0.19
115 INT89690 Binding of Brca2 2 0.37 1.8 0.18
116 INT182627 Regulation of MSH2 1 0.26 2.27 0.18
117 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
118 INT300284 Regulation of Phosphorylation of Tp53 1 0.16 1.51 0.17
119 INT337078 Negative_regulation of Localization of Trp53 1 0.20 1.3 0.17
120 INT179086 Positive_regulation of Negative_regulation of Trp53 5 0.50 4.78 0.15
121 INT139201 Localization of TP63 4 0.32 2.56 0.15
122 INT145147 Negative_regulation of Gene_expression of TP63 4 0.42 2.91 0.15
123 INT125081 Positive_regulation of Binding of TP53 2 0.46 1.2 0.15
124 INT207805 Negative_regulation of Phosphorylation of Trp53 2 0.18 0.98 0.15
125 INT298653 Positive_regulation of Binding of EP300 1 0.11 0.8 0.15
126 INT286749 Regulation of Localization of Trp53 1 0.06 1.39 0.15
127 INT154148 Negative_regulation of Gene_expression of TP73 3 0.21 1.89 0.14
128 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
129 INT256864 Gene_expression of Tp63 1 0.14 0.47 0.14
130 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
131 INT282973 Binding of Bbc3 2 0.01 2.87 0.13
132 INT89691 Regulation of Brca2 1 0.23 0.56 0.13
133 INT168244 Regulation of Transcription of Tp53 1 0.33 0.57 0.13
134 INT182623 Localization of MSH2 3 0.77 5.49 0.12
135 INT220472 Gene_expression of BAG6 1 0.11 13.93 0.12
136 INT181745 Positive_regulation of MSH2 4 0.48 5.73 0.11
137 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
138 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
139 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
140 INT307233 Localization of BCL3 1 0.19 0.84 0.11
141 INT146072 Binding of TP73 2 0.12 0.58 0.1
142 INT349072 Positive_regulation of Gene_expression of PML 1 0.13 1.49 0.1
143 INT297456 Protein_catabolism of Tp53 1 0.11 0.72 0.1
144 INT111139 Localization of Tp53 4 0.45 2.4 0.09
145 INT282824 Regulation of PML 3 0.44 2.66 0.09
146 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
147 INT15504 Positive_regulation of Msh2 1 0.33 0.15 0.09
148 INT340388 Negative_regulation of Gene_expression of Bbc3 1 0.01 0.73 0.08
149 INT256854 Regulation of Tp63 1 0.06 0.06 0.08
150 INT136890 Protein_catabolism of TP63 2 0.56 1.17 0.07
151 INT234186 Localization of BRCA2 2 0.69 1.48 0.07
152 INT352605 Regulation of Negative_regulation of Trp53 1 0.45 0.72 0.07
153 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
154 INT256136 Negative_regulation of Binding of Sirt1 1 0.30 0.5 0.07
155 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
156 INT171421 Regulation of Positive_regulation of TP53 1 0.48 0.45 0.05
157 INT265479 Positive_regulation of Localization of BBC3 1 0.49 1.18 0.05
158 INT307236 Negative_regulation of Localization of BCL3 1 0.10 0.33 0.05
159 INT256137 Positive_regulation of Regulation of Sirt1 1 0.36 0.32 0.05
160 INT265489 Localization of BBC3 1 0.73 1.17 0.05
161 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
162 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
163 INT256129 Negative_regulation of Gene_expression of Sirt1 1 0.31 0.4 0.05
164 INT292252 Phosphorylation of EP300 1 0.20 0.55 0.05
165 INT315213 Negative_regulation of Binding of Trp53 1 0.32 0.11 0.05
166 INT311668 Regulation of Regulation of TP53 2 0.36 3.58 0.04
167 INT305536 Positive_regulation of Binding of Trp53 1 0.35 0.32 0.04
168 INT356186 Positive_regulation of Regulation of PML 1 0.49 1.14 0.04
169 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
170 INT270038 Positive_regulation of Positive_regulation of Sirt1 2 0.43 0.44 0.03
171 INT217802 Regulation of Transcription of TP53 2 0.37 0.81 0.03
172 INT246622 Phosphorylation of Sirt1 2 0.74 0.56 0.03
173 INT259061 Negative_regulation of Regulation of TP53 2 0.10 2.23 0.03
174 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
175 INT204349 Regulation of SIRT1 8 0.61 1.99 0
176 INT178927 Regulation of Gene_expression of Tp53 6 0.26 2.23 0
177 INT256134 Localization of Sirt1 5 0.50 2.99 0
178 INT204353 Transcription of SIRT1 3 0.68 0.67 0
179 INT154149 Positive_regulation of Gene_expression of TP73 3 0.18 0.67 0
180 INT333669 Positive_regulation of Transcription of Trp53 3 0.45 2.33 0
181 INT209451 Regulation of Gene_expression of TP63 3 0.16 4.32 0
182 INT250698 Positive_regulation of Transcription of TP53 3 0.18 3.68 0
183 INT235154 Transcription of Ep300 2 0.24 1.38 0
184 INT190020 Gene_expression of Msh2 2 0.69 0.69 0
185 INT167536 Positive_regulation of BRCA2 2 0.49 0.29 0
186 INT113348 Negative_regulation of Binding of TP53 2 0.28 1.49 0
187 INT214913 Positive_regulation of Positive_regulation of Tp53 2 0.08 2.47 0
188 INT217820 Regulation of Negative_regulation of TP53 2 0.37 1.92 0
189 INT234191 Positive_regulation of Localization of BRCA2 1 0.46 0.68 0
190 INT204059 Positive_regulation of Phosphorylation of Tp53 1 0.07 0.76 0
191 INT222914 Negative_regulation of Gene_expression of EP300 1 0.02 0.05 0
192 INT333668 Regulation of Protein_catabolism of Trp53 1 0.24 1.58 0
193 INT206928 Transcription of MSH2 1 0.52 0.4 0
194 INT154146 Regulation of Gene_expression of TP73 1 0.16 0.26 0
195 INT314708 Gene_expression of Brca2 1 0.41 1.75 0
196 INT204361 Negative_regulation of SIRT1 1 0.42 0.18 0
197 INT182625 Positive_regulation of Localization of MSH2 1 0.45 2.47 0
198 INT289569 Transcription of Sirt1 1 0.71 0.25 0
199 INT300686 Regulation of Binding of Sirt1 1 0.44 0.06 0
200 INT154152 Negative_regulation of TP73 1 0.13 0.21 0
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