GO:0042787

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Name protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Categary Process
Go Slim No
Go Link GO:0042787
Unique Molecular Interactions 95
Total Molecular Interactions 152
Total Single Events 562
Pain Genes Associated 19

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein ubiquitination involved in ubiquitin-dependent protein catabolic process. They are ordered first by their pain relevance and then by number of times they were reported for protein ubiquitination involved in ubiquitin-dependent protein catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT244133 DDB1 Positive_regulation of Gene_expression of IL6 1 0.01 1.91 0.99
2 INT141911 Arih2 Regulation of Positive_regulation of Cpox 1 0.01 1.19 0.76
3 INT141910 Arih2 Regulation of Cpox 1 0.01 1.19 0.76
4 INT114676 Mdm2 Negative_regulation of p53-ps 1 0.10 0.26 0.48
5 INT95404 Map3k1 Positive_regulation of Phosphorylation of Ephb1 1 0.12 0.16 0.46
6 INT95408 Map3k1 Positive_regulation of Ephb1 1 0.12 0.16 0.46
7 INT168699 Binding of Nedd4 and Tyr 1 0.02 0.45 0.46
8 INT354704 Binding of MAP3K1 and Pick1 1 0.00 0.76 0.41
9 INT255934 Tauph Positive_regulation of Map3k1 1 0.00 0.1 0.32
10 INT255946 MAPK14 Positive_regulation of Map3k1 1 0.04 0.1 0.32
11 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
12 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
13 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
14 INT274932 Binding of Insrr and Map3k1 1 0.00 0 0.28
15 INT170719 Binding of Grm5 and Siah1a 1 0.01 1.1 0.28
16 INT274947 Binding of Map3k1 and Grip1 1 0.00 0 0.27
17 INT168828 Binding of DDB1 and UBR1 1 0.00 0.67 0.19
18 INT170721 Siah1a Regulation of Negative_regulation of Grm2 1 0.22 0 0.18
19 INT168700 Positive_regulation of Binding of Nedd4 and Tyr 1 0.03 0.19 0.17
20 INT170724 Binding of Grm8 and Siah1a 1 0.19 0.11 0.15
21 INT177916 PRKG1 Positive_regulation of Positive_regulation of MAP3K1 1 0.05 1.07 0.14
22 INT280488 Bdnf Positive_regulation of Gene_expression of Map3k1 1 0.01 1.49 0.11
23 INT328143 Gabrb3 Positive_regulation of Ube3a 1 0.56 0.99 0.11
24 INT328146 Gabrb3 Negative_regulation of Ube3a 1 0.48 0.99 0.11
25 INT168829 Binding of DDB1 and TRPC4AP 1 0.02 0.34 0.1
26 INT92389 ALK Positive_regulation of Gene_expression of Map3k1 1 0.01 1.14 0.09
27 INT232559 Map3k1 Positive_regulation of Esr1 1 0.19 0.26 0.09
28 INT224985 Binding of Ube3a and Snord116 1 0.34 0.45 0.08
29 INT328150 H2-Q13 Positive_regulation of Gene_expression of Ube3a 1 0.55 1.23 0.07
30 INT170722 Siah1a Regulation of Gene_expression of Grm8 1 0.24 0 0.07
31 INT328148 H2-Q13 Positive_regulation of Ube3a 1 0.55 1.23 0.07
32 INT193790 ITIH4 Regulation of Gene_expression of MDM2 1 0.06 0.45 0.07
33 INT231834 Trip12 Positive_regulation of Positive_regulation of Cel 1 0.00 0.75 0.05
34 INT342726 Binding of Laptm5 and Park2 1 0.03 0.64 0.04
35 INT250025 Map3k1 Positive_regulation of Regulation of Bcl2 1 0.01 1.1 0.04
36 INT244132 DDB1 Regulation of Transcription of NOD1 1 0.01 0.09 0.03
37 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03
38 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0
39 INT317301 Binding of Park2 and Park7 1 0.36 0.62 0
40 INT342725 Pink1 Positive_regulation of Phosphorylation of Park2 1 0.29 0.62 0
41 INT314746 Akt1 Positive_regulation of Phosphorylation of MDM2 1 0.32 1.16 0
42 INT215413 ITC1 Negative_regulation of MAP3K1 1 0.04 0.23 0
43 INT347162 MDM2 Negative_regulation of TP53 1 0.02 1.09 0
44 INT348521 TRAF2 Positive_regulation of MAP3K1 1 0.03 0.46 0
45 INT320714 Gene_expression of MDM2 Negative_regulation of TP53 1 0.16 0.88 0
46 INT333030 Binding of Itch and Trpv4 1 0.14 0 0
47 INT304028 MDM2 Regulation of TP53 1 0.19 1.11 0
48 INT306256 MDM2 Negative_regulation of Positive_regulation of TP53 1 0.23 0.44 0
49 INT170723 Binding of Calm2 and Siah1a 1 0.24 0 0
50 INT317300 Binding of Park2 and Pink1 1 0.48 1.23 0
51 INT329013 Binding of LITAF and Nedd4 1 0.15 1.4 0
52 INT273886 Binding of Dll1 and Trip12 1 0.34 0.1 0
53 INT170718 Siah1a Regulation of Grm8 1 0.24 0 0
54 INT342727 Pink1 Positive_regulation of Park2 1 0.29 0.62 0
55 INT333046 Binding of Trpv4 and ITCH 1 0.39 0 0
56 INT348689 Fgf2 Regulation of Map3k1 1 0.09 0 0
57 INT352617 Mdm2 Positive_regulation of Positive_regulation of Trp53 1 0.20 2.56 0
58 INT333450 ATM Positive_regulation of Negative_regulation of MDM2 1 0.18 0 0
59 INT317302 Binding of Park2 and Mul1 1 0.01 0.62 0
60 INT272000 Binding of Skp2 and Hecw1 1 0.01 0.11 0
61 INT333033 Binding of Itch and Laptm5 1 0.01 0 0
62 INT329012 Binding of MPZ and Nedd4 1 0.03 0.7 0
63 INT208152 Binding of CDK4 and MDM2 1 0.01 1.11 0
64 INT294523 Binding of MDM2 and PDB1 1 0.40 0.1 0
65 INT250152 Binding of APOE and UBE4B 1 0.21 1.2 0
66 INT333458 ATM Positive_regulation of MDM2 1 0.25 0 0
67 INT215416 MAP3K1 Regulation of MAPK9 1 0.14 0.64 0
68 INT325285 COMP Positive_regulation of UBR5 1 0.00 2.9 0
69 INT352614 Negative_regulation of Binding of Mdm2 and Trp53 1 0.19 1.16 0
70 INT215412 Binding of MAP3K1 and ITC1 1 0.03 0 0
71 INT294527 Binding of MDM2 and p53 1 0.40 0.1 0
72 INT294524 Binding of MDM2 and TNF 1 0.03 0.1 0
73 INT294522 Binding of IL2 and MDM2 1 0.40 0.2 0
74 INT259051 Binding of TP53 and UBE3A 1 0.01 3.48 0
75 INT214922 Binding of MDM2 and TP53 1 0.08 1.55 0
76 INT215415 MAP3K1 Regulation of MAPK8 1 0.62 0.64 0
77 INT333031 Binding of Itch and Mul1 1 0.02 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein ubiquitination involved in ubiquitin-dependent protein catabolic process. They are ordered first by their pain relevance and then by number of times they were reported in protein ubiquitination involved in ubiquitin-dependent protein catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
2 INT114675 Positive_regulation of Gene_expression of Mdm2 1 0.70 1.98 7.9
3 INT159121 Positive_regulation of Map3k1 10 0.45 8.79 2.6
4 INT170712 Gene_expression of Siah1a 1 0.77 2.33 2.33
5 INT95400 Negative_regulation of Map3k1 3 0.15 0.78 1.92
6 INT224975 Gene_expression of Ube3a 5 0.76 7.18 1.69
7 INT71788 Gene_expression of MAP3K1 13 0.70 4.9 1.66
8 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55
9 INT114671 Positive_regulation of Mdm2 1 0.61 0.5 1.38
10 INT50785 Gene_expression of Map3k1 6 0.44 4.22 1.32
11 INT114673 Regulation of Gene_expression of Mdm2 1 0.62 0.23 1.02
12 INT71784 Positive_regulation of Gene_expression of MAP3K1 4 0.34 4.8 0.82
13 INT50784 Positive_regulation of Gene_expression of Map3k1 2 0.06 0.94 0.8
14 INT177933 Positive_regulation of MAP3K1 6 0.42 4.13 0.76
15 INT170695 Binding of Siah1a 1 0.48 1.19 0.59
16 INT111602 Negative_regulation of Gene_expression of MAP3K1 1 0.06 0.58 0.58
17 INT95401 Phosphorylation of Map3k1 1 0.21 0.16 0.46
18 INT244151 Localization of DDB1 1 0.02 0.05 0.4
19 INT168697 Binding of Nedd4 1 0.26 0.48 0.38
20 INT172957 Negative_regulation of Mdm2 4 0.14 4.28 0.3
21 INT102721 Negative_regulation of MAP3K1 2 0.53 8.03 0.3
22 INT224979 Negative_regulation of Ube3a 2 0.57 3.18 0.29
23 INT170714 Regulation of Gene_expression of Siah1a 1 0.61 0.71 0.25
24 INT177941 Phosphorylation of MAP3K1 2 0.20 1.31 0.24
25 INT167250 Regulation of Gene_expression of MDM2 1 0.06 0.86 0.21
26 INT168693 Negative_regulation of Binding of Nedd4 1 0.31 0.29 0.21
27 INT168696 Positive_regulation of Binding of Nedd4 1 0.34 0.29 0.21
28 INT98785 Negative_regulation of Gene_expression of Map3k1 1 0.03 0.69 0.21
29 INT88744 Positive_regulation of Gene_expression of MDM2 9 0.43 7.82 0.2
30 INT172958 Positive_regulation of Mdm2 4 0.56 2.43 0.19
31 INT328135 Negative_regulation of Gene_expression of Ube3a 1 0.42 0.9 0.19
32 INT34862 Gene_expression of UBE4B 7 0.50 4.65 0.18
33 INT126733 Regulation of MDM2 2 0.36 0.73 0.16
34 INT154200 Binding of Map3k1 1 0.06 0.32 0.16
35 INT328136 Transcription of Ube3a 1 0.67 0 0.16
36 INT217993 Positive_regulation of Ube3a 1 0.41 0.62 0.16
37 INT113346 Binding of MDM2 10 0.35 5.73 0.15
38 INT266010 Localization of Mdm2 2 0.75 2.64 0.15
39 INT204054 Negative_regulation of Negative_regulation of Mdm2 2 0.14 2.23 0.15
40 INT286764 Regulation of Localization of Mdm2 1 0.14 1.38 0.15
41 INT286748 Regulation of Mdm2 1 0.14 1.37 0.15
42 INT231822 Positive_regulation of Trip12 1 0.01 0.32 0.14
43 INT175517 Gene_expression of Mdm2 18 0.78 16.28 0.13
44 INT170700 Positive_regulation of Gene_expression of Siah1a 1 0.50 0.36 0.13
45 INT170710 Negative_regulation of Siah1a 1 0.43 0.1 0.12
46 INT170701 Negative_regulation of Localization of Siah1a 1 0.42 0 0.11
47 INT170696 Localization of Siah1a 1 0.74 0 0.11
48 INT170699 Positive_regulation of Siah1a 1 0.50 0.08 0.1
49 INT259063 Binding of UBE3A 2 0.36 1.15 0.09
50 INT173169 Regulation of MAP3K1 2 0.41 1.81 0.09
51 INT114041 Regulation of Arih2 1 0.34 0.25 0.09
52 INT92387 Gene_expression of Map3k1 1 0.02 1.13 0.09
53 INT244174 Positive_regulation of DDB1 1 0.01 0.41 0.09
54 INT308642 Localization of UBE4B 1 0.06 0.32 0.09
55 INT321381 Localization of Arih2 1 0.08 1.63 0.08
56 INT151835 Positive_regulation of UBE4B 1 0.48 0.68 0.08
57 INT342696 Gene_expression of Park2 1 0.65 1.19 0.08
58 INT224950 Regulation of Gene_expression of Ube3a 1 0.25 0.68 0.07
59 INT244138 Transcription of DDB1 1 0.02 0 0.06
60 INT170698 Regulation of Siah1a 1 0.45 0.36 0.06
61 INT170704 Negative_regulation of Binding of Siah1a 1 0.42 0 0.06
62 INT250022 Regulation of Map3k1 2 0.18 1.02 0.04
63 INT319263 Localization of Ube3a 2 0.73 1.09 0.04
64 INT317299 Binding of Park2 1 0.36 0.61 0.04
65 INT287282 Regulation of Binding of MDM2 1 0.04 0.63 0.04
66 INT176240 Phosphorylation of Mdm2 2 0.22 1.28 0.03
67 INT176252 Positive_regulation of Phosphorylation of Mdm2 1 0.14 0.42 0.03
68 INT126734 Positive_regulation of MDM2 8 0.49 5.56 0
69 INT244259 Gene_expression of UBE3A 4 0.78 1.91 0
70 INT266011 Positive_regulation of Gene_expression of Mdm2 3 0.47 4.61 0
71 INT244139 Gene_expression of DDB1 3 0.02 0.45 0
72 INT186224 Binding of UBE4B 3 0.22 0.32 0
73 INT260276 Negative_regulation of MDM2 2 0.42 0.62 0
74 INT276357 Protein_catabolism of MDM2 2 0.32 1.18 0
75 INT224970 Regulation of Ube3a 2 0.44 0.31 0
76 INT276370 Phosphorylation of MDM2 2 0.50 1.99 0
77 INT202475 Positive_regulation of Positive_regulation of Map3k1 2 0.33 1.54 0
78 INT342695 Phosphorylation of Park2 1 0.79 0.62 0
79 INT294536 Localization of MDM2 1 0.73 0.09 0
80 INT273854 Gene_expression of Trip12 1 0.63 0.08 0
81 INT273863 Binding of Trip12 1 0.39 0.1 0
82 INT215426 Negative_regulation of Negative_regulation of MAP3K1 1 0.39 0.32 0
83 INT121497 Transcription of MDM2 1 0.54 0.12 0
84 INT189990 Negative_regulation of Map3k1 1 0.01 1.48 0
85 INT235473 Negative_regulation of Gene_expression of MDM2 1 0.18 0.99 0
86 INT244258 Negative_regulation of Gene_expression of UBE3A 1 0.59 0.82 0
87 INT170691 Protein_catabolism of Siah1a 1 0.88 0.34 0
88 INT217339 Protein_catabolism of UBE3A 1 0.14 1.79 0
89 INT328129 Binding of Ube3a 1 0.32 0.15 0
90 INT333019 Binding of Itch 1 0.13 0 0
91 INT333617 Transcription of MAP3K1 1 0.23 0.09 0
92 INT215425 Positive_regulation of Negative_regulation of MAP3K1 1 0.45 0.78 0
93 INT333021 Negative_regulation of Positive_regulation of Itch 1 0.14 0 0
94 INT328131 Positive_regulation of Gene_expression of Ube3a 1 0.49 0.29 0
95 INT328134 Protein_catabolism of Ube3a 1 0.86 0 0
96 INT126986 Gene_expression of UBR5 1 0.26 0 0
97 INT276343 Regulation of Phosphorylation of MDM2 1 0.14 0.85 0
98 INT250156 Negative_regulation of Gene_expression of UBE4B 1 0.29 0.43 0
99 INT276359 Positive_regulation of Protein_catabolism of MDM2 1 0.15 1.79 0
100 INT273859 Negative_regulation of Gene_expression of Trip12 1 0.48 0.08 0
101 INT215419 Regulation of Localization of MAP3K1 1 0.41 0.22 0
102 INT276366 Positive_regulation of Phosphorylation of MDM2 1 0.15 0.85 0
103 INT170688 Regulation of Protein_catabolism of Siah1a 1 0.23 0.17 0
104 INT113347 Negative_regulation of Binding of MDM2 1 0.25 0.13 0
105 INT215423 Localization of MAP3K1 1 0.68 0.22 0
106 INT244260 Negative_regulation of UBE3A 1 0.59 0.86 0
107 INT333024 Positive_regulation of Itch 1 0.17 0 0
108 INT325286 Positive_regulation of UBR5 1 0.02 2.37 0
109 INT333621 Positive_regulation of Transcription of MAP3K1 1 0.16 0.09 0
110 INT215428 Binding of MAP3K1 1 0.44 0.05 0
111 INT202470 Negative_regulation of Positive_regulation of Map3k1 1 0.38 0.62 0
112 INT276365 Negative_regulation of Protein_catabolism of MDM2 1 0.14 0.86 0
113 INT266009 Negative_regulation of Gene_expression of Mdm2 1 0.43 1.03 0
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