GO:0042789

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Name mRNA transcription from RNA polymerase II promoter
Categary Process
Go Slim No
Go Link GO:0042789
Unique Molecular Interactions 123
Total Molecular Interactions 166
Total Single Events 1215
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for mRNA transcription from RNA polymerase II promoter. They are ordered first by their pain relevance and then by number of times they were reported for mRNA transcription from RNA polymerase II promoter. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT118568 Binding of Ddit3 and Atf6 1 0.33 0.85 0.66
2 INT100369 HIF1A Positive_regulation of Positive_regulation of VEGFA 1 0.29 0.99 0.62
3 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46
4 INT285935 IL6 Positive_regulation of Gene_expression of POU5F1 1 0.14 2.68 0.37
5 INT198647 TNF Positive_regulation of HIF1A 1 0.03 2.97 0.34
6 INT318678 Atf4 Positive_regulation of Gene_expression of Ddit3 1 0.53 0.77 0.23
7 INT254349 Positive_regulation of Binding of EPAS1 and HIF1A 1 0.00 0.92 0.23
8 INT162850 ISYNA1 Positive_regulation of Localization of HIF1A 1 0.05 0.25 0.21
9 INT305003 HIF1A Regulation of SERPINE1 1 0.11 2.3 0.19
10 INT318682 Atf4 Positive_regulation of Ddit3 1 0.73 1.71 0.18
11 INT318677 Xbp1 Positive_regulation of Ddit3 1 0.73 1.72 0.18
12 INT198649 Binding of HIF1A and MIF 1 0.01 1.53 0.18
13 INT318680 Binding of Cebpg and Ddit3 1 0.39 1.73 0.18
14 INT130690 Gene_expression of HSPA5 Negative_regulation of Positive_regulation of DDIT3 1 0.21 0.58 0.17
15 INT143440 HIF1A Positive_regulation of Gene_expression of VEGFA 1 0.52 0.45 0.17
16 INT181898 Binding of ROS1 and Positive_regulation of HIF1A 1 0.02 0.82 0.15
17 INT181897 ROS1 Negative_regulation of HIF1A 1 0.03 0.83 0.15
18 INT156833 Binding of MED1 and TRPV6 1 0.32 0 0.15
19 INT156837 Binding of CYP24A1 and MED1 1 0.47 0 0.15
20 INT181895 ROS1 Positive_regulation of HIF1A 1 0.03 0.78 0.15
21 INT181894 ROS1 Regulation of HIF1A 1 0.02 0.82 0.13
22 INT198671 HIF1A Regulation of Positive_regulation of Epo 1 0.00 1.37 0.13
23 INT147362 Mapk9 Positive_regulation of Ddit3 1 0.57 0.76 0.12
24 INT305002 Binding of HIF1A and SERPINE1 1 0.07 1.17 0.11
25 INT199583 HIF1A Positive_regulation of Gene_expression of Vhl 1 0.26 1.39 0.11
26 INT312305 Binding of HIF1A and Positive_regulation of Transcription of VEGFA 1 0.17 2.8 0.1
27 INT102244 IL36RN Positive_regulation of Binding of HIF1A 1 0.06 1.07 0.1
28 INT102245 TNF Positive_regulation of Binding of HIF1A 1 0.18 1.09 0.1
29 INT102248 INS Positive_regulation of Binding of HIF1A 1 0.13 0.96 0.1
30 INT294455 KLK4 Negative_regulation of HIF1A 1 0.01 0 0.1
31 INT102246 Binding of HIF1A and INS 1 0.07 0.96 0.1
32 INT173061 Binding of HIF1A and LILRA3 1 0.03 1.24 0.09
33 INT173062 Binding of HIF1A and VHLL 1 0.04 1.26 0.09
34 INT173057 Positive_regulation of HIF1A Positive_regulation of Gene_expression of VEGFA 1 0.24 1.49 0.08
35 INT192863 Binding of Ddit3 and Esr1 1 0.09 0.67 0.08
36 INT178081 Negative_regulation of EDN1 Positive_regulation of HIF1A 1 0.04 1.18 0.08
37 INT178078 Positive_regulation of Binding of DBP and HIF1A 1 0.00 1 0.08
38 INT178080 EDN1 Positive_regulation of HIF1A 1 0.05 1.05 0.08
39 INT215879 Ddit3 Regulation of Regulation of Atf4 1 0.26 0.29 0.07
40 INT178103 Binding of DBP and HIF1A 1 0.00 0.99 0.07
41 INT215874 Positive_regulation of Eif2ak3 Positive_regulation of Positive_regulation of Ddit3 1 0.47 0.31 0.07
42 INT355432 Gene_expression of Pdia3 Negative_regulation of Ddit3 1 0.04 1.29 0.06
43 INT225490 Med1 Positive_regulation of Ppara 1 0.12 0.26 0.06
44 INT355431 Binding of Pdia3 and Positive_regulation of Gene_expression of Ddit3 1 0.04 1.14 0.06
45 INT355433 Gene_expression of Pdia3 Negative_regulation of Transcription of Ddit3 1 0.03 1.79 0.06
46 INT355434 Binding of Pdia3 and Positive_regulation of Transcription of Ddit3 1 0.04 1.14 0.06
47 INT215873 Ddit3 Regulation of Eif2ak3 1 0.39 0.2 0.06
48 INT355438 Gene_expression of Pdia3 Negative_regulation of Gene_expression of Ddit3 1 0.05 4.79 0.06
49 INT282552 POU5F1 Positive_regulation of FGF4 1 0.29 0.29 0.05
50 INT215871 Atf4 Regulation of Ddit3 1 0.26 0.43 0.04
51 INT102247 Binding of EPO and HIF1A 1 0.41 0.65 0.04
52 INT173060 Negative_regulation of VHLL Positive_regulation of Positive_regulation of HIF1A 1 0.04 0.66 0.04
53 INT282555 POU5F1 Positive_regulation of Positive_regulation of MAPK1 1 0.11 0.28 0.04
54 INT261393 Binding of Nsdhl and Med1 1 0.02 1 0.04
55 INT282556 POU5F1 Positive_regulation of GOPC 1 0.06 0.06 0.04
56 INT252818 PPP2R4 Regulation of Positive_regulation of DDIT3 1 0.04 3.07 0.04
57 INT285936 IL17A Positive_regulation of Gene_expression of POU5F1 1 0.10 0.34 0.04
58 INT282561 POU5F1 Positive_regulation of Gene_expression of NANOG 1 0.11 0.26 0.04
59 INT355430 Pdia3 Regulation of Gene_expression of Ddit3 1 0.04 1 0.03
60 INT282543 KDM4C Regulation of POU5F1 1 0.06 0.08 0.03
61 INT282542 KDM3A Regulation of POU5F1 1 0.06 0.08 0.03
62 INT355441 VEGFA Positive_regulation of Gene_expression of Ddit3 1 0.05 0.43 0.03
63 INT316773 Esr1 Positive_regulation of Ddit3 1 0.02 0.41 0.03
64 INT282553 POU5F1 Positive_regulation of REXO1 1 0.21 0.1 0.03
65 INT219423 Binding of AHR and ARNT 4 0.24 0.46 0
66 INT225585 Regulation of Binding of Med1 and Tpr 1 0.00 0.07 0
67 INT189554 Binding of HIF1A and Positive_regulation of EGLN1 1 0.04 0.86 0
68 INT143438 HIF1A Regulation of Gene_expression of VEGFA 1 0.69 0.13 0
69 INT315543 NARFL Regulation of Gene_expression of HIF1A 1 0.01 0.63 0
70 INT219418 ARNT Positive_regulation of Localization of AHR 1 0.25 0 0
71 INT316774 Hsp90b1 Positive_regulation of Localization of Ddit3 1 0.12 0.17 0
72 INT282559 NANOG Regulation of POU5F1 1 0.14 0.45 0
73 INT355437 Negative_regulation of Pdia3 Positive_regulation of Gene_expression of Ddit3 1 0.04 0.47 0
74 INT282554 Binding of POU5F1 and SOX2 1 0.19 0.1 0
75 INT316770 Hsp90b1 Positive_regulation of Ddit3 1 0.12 0.17 0
76 INT177262 Binding of MED1 and SV2A 1 0.23 0 0
77 INT140607 PMEL Positive_regulation of Gene_expression of DDIT3 1 0.01 0.75 0
78 INT252842 ENOPH1 Positive_regulation of Gene_expression of Ddit3 1 0.06 2.42 0
79 INT282551 SOX2 Regulation of POU5F1 1 0.24 0.45 0
80 INT241307 Positive_regulation of HIF1A Positive_regulation of Positive_regulation of EPO 1 0.12 0.64 0
81 INT290478 Mitf Positive_regulation of HIF1A 1 0.57 0.61 0
82 INT282541 SOX2 Regulation of Transcription of POU5F1 1 0.24 0.05 0
83 INT189552 EGLN1 Positive_regulation of HIF1A 1 0.05 0.98 0
84 INT355436 Pdia3 Regulation of Transcription of Ddit3 1 0.04 0.59 0
85 INT282558 POU5F1 Positive_regulation of MAPK1 1 0.16 0.26 0
86 INT225481 Binding of Med1 and Acp5 1 0.16 0 0
87 INT282607 POU5F1 Positive_regulation of Mdk 1 0.08 0.26 0
88 INT285946 IL6 Regulation of POU5F1 1 0.05 0.12 0
89 INT337352 Binding of ARNT and HIF1A 1 0.14 0.61 0
90 INT119045 HIF1A Regulation of Regulation of TP53 1 0.09 1.06 0
91 INT177286 Binding of CXADR and MED1 1 0.27 0 0
92 INT119046 HIF1A Regulation of TP53 1 0.05 1.06 0
93 INT219505 ARNT Positive_regulation of Positive_regulation of Ppib 1 0.50 0 0
94 INT316772 Calr Positive_regulation of Ddit3 1 0.10 0.12 0
95 INT225541 Binding of Med1 and Tpr 1 0.00 0.07 0
96 INT282549 POU5F1 Regulation of Transcription of SOX2 1 0.32 0.05 0
97 INT316771 Calr Positive_regulation of Localization of Ddit3 1 0.10 0.12 0
98 INT143439 Positive_regulation of HIF1A Regulation of Gene_expression of VEGFA 1 0.30 0.13 0
99 INT282539 POU5F1 Regulation of Gene_expression of NANOG 1 0.17 0 0
100 INT252792 ENOPH1 Positive_regulation of Gene_expression of DDIT3 1 0.03 2.42 0
101 INT177280 Binding of MED1 and FAUP1 1 0.01 0 0
102 INT290479 Binding of HIF1A and Mitf 1 0.30 1.29 0
103 INT174720 Ddit3 Regulation of Gtf3a 1 0.01 0.35 0
104 INT119044 HIF1A Regulation of TCEAL1 1 0.02 1.06 0
105 INT313884 XRCC1 Positive_regulation of Localization of HIF1A 1 0.00 0.65 0
106 INT119047 HIF1A Regulation of Regulation of TCEAL1 1 0.08 1.06 0
107 INT345487 HIF1A Positive_regulation of PMAIP1 1 0.27 1.23 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for mRNA transcription from RNA polymerase II promoter. They are ordered first by their pain relevance and then by number of times they were reported in mRNA transcription from RNA polymerase II promoter. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66
2 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4
3 INT128159 Positive_regulation of DDIT3 29 0.67 29.5 8.99
4 INT128161 Gene_expression of DDIT3 20 0.75 17.14 5.13
5 INT116150 Positive_regulation of Ddit3 26 0.67 22.58 5.01
6 INT154527 Gene_expression of POU5F1 180 0.78 34.01 4.34
7 INT118565 Gene_expression of Ddit3 35 0.75 23.62 4.32
8 INT142483 Positive_regulation of Gene_expression of DDIT3 15 0.67 11.39 3.47
9 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05
10 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88
11 INT100381 Positive_regulation of Positive_regulation of HIF1A 12 0.49 12.05 2.17
12 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13
13 INT96881 Gene_expression of ARNT 8 0.50 3.27 1.98
14 INT141166 Positive_regulation of Gene_expression of Ddit3 15 0.56 10.32 1.92
15 INT173419 Gene_expression of Ddit3 16 0.75 23.31 1.87
16 INT119048 Negative_regulation of Gene_expression of HIF1A 10 0.57 9.23 1.5
17 INT143443 Localization of HIF1A 14 0.78 10.93 1.49
18 INT282590 Positive_regulation of Gene_expression of POU5F1 40 0.70 8.42 1.32
19 INT128160 Regulation of DDIT3 3 0.57 2.45 1.29
20 INT165800 Positive_regulation of Ddit3 17 0.67 11.69 1.21
21 INT116144 Positive_regulation of Positive_regulation of Ddit3 2 0.41 2.95 1.2
22 INT282572 Positive_regulation of POU5F1 24 0.70 5.8 1.13
23 INT102249 Binding of HIF1A 39 0.36 30.47 1.04
24 INT152407 Negative_regulation of Gene_expression of DDIT3 3 0.40 0.87 1.02
25 INT152408 Binding of DDIT3 3 0.35 2.06 1
26 INT116140 Localization of Ddit3 2 0.57 1.94 0.96
27 INT155352 Phosphorylation of HIF1A 3 0.79 3.34 0.83
28 INT100378 Protein_catabolism of HIF1A 7 0.96 5.05 0.8
29 INT169731 Negative_regulation of Localization of HIF1A 1 0.57 0.57 0.73
30 INT100380 Negative_regulation of Positive_regulation of HIF1A 2 0.57 1.6 0.72
31 INT282599 Regulation of Gene_expression of POU5F1 10 0.62 4.89 0.71
32 INT318666 Negative_regulation of Ddit3 1 0.56 6.86 0.7
33 INT118564 Regulation of Gene_expression of Ddit3 1 0.55 0.89 0.68
34 INT128795 Regulation of Positive_regulation of HIF1A 2 0.61 0.95 0.67
35 INT318667 Negative_regulation of Gene_expression of Ddit3 6 0.56 3.16 0.65
36 INT100382 Positive_regulation of Protein_catabolism of HIF1A 2 0.45 1.75 0.64
37 INT100377 Negative_regulation of Protein_catabolism of HIF1A 1 0.57 0.9 0.63
38 INT112363 Regulation of Gene_expression of HIF1A 6 0.60 2.28 0.61
39 INT155353 Positive_regulation of Phosphorylation of HIF1A 1 0.49 2.58 0.61
40 INT128162 Negative_regulation of Positive_regulation of DDIT3 4 0.41 4.54 0.53
41 INT230634 Negative_regulation of POU5F1 10 0.43 1.03 0.46
42 INT157308 Regulation of Gene_expression of DDIT3 1 0.44 0.45 0.46
43 INT173418 Transcription of Ddit3 6 0.65 7.91 0.41
44 INT96870 Transcription of ARNT 1 0.44 0.81 0.4
45 INT145045 Gene_expression of Med1 29 0.65 5.37 0.39
46 INT233917 Gene_expression of MED1 2 0.20 0.17 0.38
47 INT202373 Transcription of Ddit3 6 0.62 5.52 0.29
48 INT173105 Transcription of HIF1A 6 0.67 4.47 0.28
49 INT106734 Phosphorylation of MED1 4 0.74 1.65 0.28
50 INT282571 Negative_regulation of Positive_regulation of POU5F1 1 0.38 0 0.28
51 INT154749 Negative_regulation of Gene_expression of Ddit3 2 0.41 1.15 0.27
52 INT215850 Regulation of Ddit3 5 0.50 6.15 0.25
53 INT252833 Positive_regulation of Gene_expression of Ddit3 4 0.67 7.58 0.25
54 INT96872 Positive_regulation of ARNT 2 0.32 1.82 0.23
55 INT157020 Negative_regulation of DDIT3 2 0.42 2.39 0.23
56 INT96878 Positive_regulation of Gene_expression of ARNT 1 0.32 0.44 0.23
57 INT96880 Positive_regulation of Transcription of ARNT 1 0.30 0.44 0.23
58 INT173103 Positive_regulation of Transcription of HIF1A 3 0.49 2.11 0.21
59 INT96874 Regulation of Transcription of ARNT 1 0.29 0.38 0.18
60 INT282576 Negative_regulation of Gene_expression of POU5F1 12 0.43 2.79 0.16
61 INT157019 Regulation of Positive_regulation of DDIT3 2 0.26 2.1 0.16
62 INT106730 Regulation of Phosphorylation of MED1 2 0.24 0.7 0.16
63 INT157021 Positive_regulation of Positive_regulation of DDIT3 2 0.49 1.78 0.16
64 INT215885 Transcription of DDIT3 3 0.69 2.57 0.13
65 INT215886 Positive_regulation of Transcription of DDIT3 2 0.49 2.32 0.13
66 INT106731 Negative_regulation of Phosphorylation of MED1 1 0.02 0.96 0.12
67 INT278790 Binding of POU5F1 8 0.43 0.67 0.11
68 INT143825 Regulation of Ddit3 3 0.58 2.03 0.11
69 INT105392 Positive_regulation of Binding of HIF1A 5 0.45 3.83 0.1
70 INT173416 Localization of Ddit3 2 0.71 0.98 0.08
71 INT173421 Positive_regulation of Transcription of Ddit3 2 0.47 0.7 0.08
72 INT327269 Regulation of Transcription of Ddit3 1 0.06 1.24 0.08
73 INT174717 Negative_regulation of Transcription of Ddit3 1 0.32 0.5 0.08
74 INT174709 Positive_regulation of Positive_regulation of Ddit3 1 0.38 0.85 0.08
75 INT263568 Negative_regulation of Positive_regulation of Ddit3 1 0.47 0.98 0.08
76 INT173420 Regulation of Gene_expression of Ddit3 2 0.37 0.84 0.07
77 INT278785 Positive_regulation of Binding of POU5F1 2 0.45 0.19 0.07
78 INT156864 Positive_regulation of Phosphorylation of MED1 1 0.45 0 0.07
79 INT143444 Positive_regulation of Localization of HIF1A 3 0.45 1.26 0.06
80 INT279378 Negative_regulation of Ddit3 2 0.30 1.35 0.06
81 INT216377 Transcription of POU5F1 9 0.69 0.58 0.05
82 INT282603 Positive_regulation of Positive_regulation of POU5F1 1 0.45 0 0.05
83 INT155174 Regulation of Regulation of HIF1A 3 0.24 1.57 0.04
84 INT316762 Binding of Ddit3 1 0.11 0.14 0.04
85 INT173079 Positive_regulation of Regulation of HIF1A 1 0.26 0.64 0.04
86 INT105389 Negative_regulation of Binding of HIF1A 4 0.42 3.2 0.03
87 INT215856 Positive_regulation of Transcription of Ddit3 2 0.60 2.12 0.03
88 INT282944 Negative_regulation of Negative_regulation of POU5F1 1 0.11 0 0.03
89 INT282605 Regulation of POU5F1 4 0.55 0.4 0
90 INT219493 Binding of ARNT 3 0.23 1.4 0
91 INT282585 Localization of POU5F1 3 0.67 0.08 0
92 INT307189 Localization of Med1 3 0.53 0.32 0
93 INT219456 Localization of ARNT 2 0.48 0.61 0
94 INT225400 Positive_regulation of Gene_expression of Med1 2 0.35 0.82 0
95 INT189607 Regulation of Binding of HIF1A 2 0.06 1.49 0
96 INT225358 Negative_regulation of Gene_expression of Med1 2 0.30 1.16 0
97 INT177336 Positive_regulation of Binding of MED1 1 0.24 0 0
98 INT278808 Regulation of Binding of POU5F1 1 0.01 0 0
99 INT307197 Negative_regulation of Med1 1 0.30 0.7 0
100 INT309646 Negative_regulation of Transcription of POU5F1 1 0.43 0 0
101 INT307188 Transcription of Med1 1 0.48 0.7 0
102 INT281337 Regulation of ARNT 1 0.05 0.59 0
103 INT189594 Negative_regulation of Transcription of HIF1A 1 0.05 0.94 0
104 INT225389 Regulation of Binding of Med1 1 0.17 0.07 0
105 INT177320 Binding of MED1 1 0.25 0 0
106 INT225457 Binding of Med1 1 0.35 0.28 0
107 INT239375 Localization of DDIT3 1 0.38 0.79 0
108 INT294842 Positive_regulation of Negative_regulation of POU5F1 1 0.41 0.49 0
109 INT341851 Positive_regulation of MED1 1 0.01 0.5 0
110 INT189606 Regulation of Transcription of HIF1A 1 0.06 0.46 0
111 INT281335 Negative_regulation of ARNT 1 0.02 0.31 0
112 INT334482 Regulation of Gene_expression of Med1 1 0.17 0.1 0
113 INT239374 Positive_regulation of Localization of DDIT3 1 0.25 0.8 0
114 INT334481 Negative_regulation of Localization of Med1 1 0.16 0.09 0
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