GO:0042824

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Name MHC class I peptide loading complex
Categary Component
Go Slim No
Go Link GO:0042824
Unique Molecular Interactions 35
Total Molecular Interactions 45
Total Single Events 330
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for MHC class I peptide loading complex. They are ordered first by their pain relevance and then by number of times they were reported for MHC class I peptide loading complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT129881 Binding of Calr and Cbll1 1 0.00 0.58 0.84
2 INT316673 Binding of CALR and LRP1 1 0.39 1.89 0.74
3 INT318981 Binding of CALR and GOPC 1 0.03 0.77 0.64
4 INT316675 Binding of CALR and SFTPD 1 0.35 0.96 0.37
5 INT39594 TPO Positive_regulation of CALR 1 0.30 0.91 0.32
6 INT318980 Binding of CALR and Positive_regulation of Localization of GOPC 1 0.04 0.32 0.24
7 INT354114 Binding of CALR and SST 1 0.01 0.1 0.16
8 INT317243 Npy Positive_regulation of Tap2 1 0.08 0 0.1
9 INT317260 Pyy Positive_regulation of Tap2 1 0.09 0 0.1
10 INT192860 Binding of Calr and Esr1 1 0.06 0.67 0.08
11 INT317257 Binding of Tap2 and Pyy 1 0.06 0 0.05
12 INT317242 Binding of Tap2 and Npy 1 0.05 0 0.05
13 INT335702 Esr1 Regulation of Calr 1 0.03 0 0.04
14 INT181168 Binding of CD79A and TAPBP 1 0.10 0.7 0.04
15 INT335703 Esr1 Regulation of Localization of Calr 1 0.03 0 0.04
16 INT225027 Binding of TAPBP and TRERF1 1 0.33 0 0.04
17 INT181169 TAPBP Negative_regulation of MALT1 1 0.00 0.48 0
18 INT181167 TAPBP Negative_regulation of CD79A 1 0.11 0.48 0
19 INT336994 CALR Negative_regulation of ESR1 1 0.04 0 0
20 INT335705 Binding of ITGA4 and Calr 1 0.01 0.43 0
21 INT351732 SSD Regulation of CALR 1 0.01 2.95 0
22 INT307306 Gene_expression of COMP Positive_regulation of CALR 1 0.27 0.99 0
23 INT307305 Gene_expression of COMP Positive_regulation of Positive_regulation of CALR 1 0.27 0.41 0
24 INT333928 Binding of CALR and ESR1 1 0.09 0.09 0
25 INT351733 CALR Positive_regulation of ROS1 1 0.03 0.3 0
26 INT351730 CALR Positive_regulation of Positive_regulation of ROS1 1 0.02 0.72 0
27 INT181165 TAPBP Regulation of Gene_expression of CD79A 1 0.07 0.35 0
28 INT189109 Tap1 Regulation of Tap2 1 0.27 0.29 0
29 INT316772 Calr Positive_regulation of Ddit3 1 0.10 0.12 0
30 INT333931 Binding of CALR and PDIA3 1 0.18 0.18 0
31 INT307309 Binding of CALR and EREG 1 0.00 0.83 0
32 INT316771 Calr Positive_regulation of Localization of Ddit3 1 0.10 0.12 0
33 INT279131 LTF Positive_regulation of CALR 1 0.03 2.39 0
34 INT307310 Binding of CALR and COMP 1 0.28 0.82 0
35 INT189103 Binding of Tap1 and Tap2 1 0.21 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for MHC class I peptide loading complex. They are ordered first by their pain relevance and then by number of times they were reported in MHC class I peptide loading complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT54555 Negative_regulation of CALR 10 0.41 4.41 2.4
2 INT93753 Positive_regulation of Tap2 1 0.57 1.31 2.21
3 INT70526 Binding of CALR 11 0.35 7.09 1.97
4 INT21941 Regulation of CALR 7 0.53 3.88 1.96
5 INT98687 Gene_expression of Calr 38 0.61 7.03 1.59
6 INT66118 Binding of Calr 4 0.46 1.46 1.26
7 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25
8 INT132531 Positive_regulation of TAPBP 8 0.49 2.84 1.09
9 INT21940 Positive_regulation of CALR 15 0.40 17.42 0.95
10 INT122101 Negative_regulation of Tap2 4 0.25 0.36 0.82
11 INT132528 Gene_expression of TAPBP 17 0.65 5.93 0.69
12 INT78257 Transcription of Tap2 1 0.28 0.59 0.62
13 INT177557 Positive_regulation of Calr 12 0.48 5.47 0.61
14 INT162801 Localization of CALR 7 0.73 8.69 0.6
15 INT11458 Binding of Tap2 3 0.39 2.51 0.57
16 INT78254 Gene_expression of Tap2 4 0.54 2.59 0.56
17 INT139674 Regulation of TAPBP 2 0.44 1.34 0.46
18 INT78256 Regulation of Gene_expression of Tap2 2 0.28 0.38 0.32
19 INT195871 Positive_regulation of Gene_expression of CALR 9 0.29 3 0.27
20 INT318982 Positive_regulation of Binding of CALR 1 0.09 0.32 0.24
21 INT222087 Regulation of Calr 3 0.42 0.56 0.22
22 INT117251 Positive_regulation of Localization of TAPBP 1 0.40 0.8 0.22
23 INT117250 Localization of TAPBP 1 0.61 0.8 0.22
24 INT335675 Localization of Calr 1 0.63 1.23 0.2
25 INT132529 Binding of TAPBP 8 0.47 1.43 0.18
26 INT177555 Regulation of Gene_expression of Calr 3 0.28 0.82 0.16
27 INT177554 Positive_regulation of Gene_expression of Calr 3 0.37 1.08 0.14
28 INT335686 Regulation of Localization of Calr 1 0.48 0.12 0.12
29 INT192855 Transcription of Calr 1 0.11 0.99 0.08
30 INT172369 Negative_regulation of Gene_expression of TAPBP 1 0.09 0.25 0.07
31 INT354146 Regulation of Gene_expression of CALR 1 0.04 0.73 0.07
32 INT181175 Negative_regulation of TAPBP 1 0.35 0.81 0.05
33 INT316766 Negative_regulation of Calr 2 0.40 0.71 0.03
34 INT242969 Protein_catabolism of Calr 2 0.68 0.94 0.03
35 INT353546 Positive_regulation of Localization of CALR 1 0.05 0.49 0.03
36 INT307326 Negative_regulation of Gene_expression of CALR 3 0.25 1.78 0
37 INT273277 Phosphorylation of Calr 2 0.56 0.82 0
38 INT132530 Positive_regulation of Binding of TAPBP 1 0.67 0.08 0
39 INT335676 Positive_regulation of Localization of Calr 1 0.48 0 0
40 INT335682 Negative_regulation of Positive_regulation of Calr 1 0.29 0 0
41 INT189094 Positive_regulation of Gene_expression of Tap2 1 0.37 0.14 0
42 INT307324 Positive_regulation of Positive_regulation of CALR 1 0.25 0.36 0
43 INT189099 Localization of Tap2 1 0.39 0.33 0
44 INT335679 Negative_regulation of Gene_expression of Calr 1 0.29 0 0
45 INT335685 Negative_regulation of Localization of Calr 1 0.29 0 0
46 INT307331 Negative_regulation of Positive_regulation of CALR 1 0.29 0.36 0
47 INT132527 Positive_regulation of Gene_expression of TAPBP 1 0.49 0.84 0
48 INT335678 Regulation of Binding of Calr 1 0.35 0 0
49 INT307332 Negative_regulation of Localization of CALR 1 0.29 0.72 0
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