GO:0042826

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Name histone deacetylase binding
Categary Function
Go Slim No
Go Link GO:0042826
Unique Molecular Interactions 677
Total Molecular Interactions 829
Total Single Events 6201
Pain Genes Associated 66

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for histone deacetylase binding. They are ordered first by their pain relevance and then by number of times they were reported for histone deacetylase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT94204 NCOR2 Regulation of Gene_expression of SP5 1 0.02 2.15 3.12
2 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
3 INT227493 Binding of TCEA1 and SIRT2 1 0.01 1.55 1.93
4 INT351281 AP1M2 Regulation of NCOR2 1 0.00 0.85 1.9
5 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
6 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
7 INT148090 Binding of CALCA and NCOR2 1 0.00 0.65 1.71
8 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
9 INT21570 Binding of Cck and Mapk8 1 0.06 0 1.6
10 INT149632 Binding of HK1 and NCOR2 1 0.01 0.13 1.58
11 INT27932 Binding of CCK and NCOR2 1 0.01 0.91 1.47
12 INT157540 Binding of SP1 and YY1 1 0.41 2.55 1.42
13 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
14 INT168865 Cd38 Regulation of Wdtc1 1 0.03 0.12 1.35
15 INT148778 Binding of Usf1 and Rtn1 1 0.40 0.85 1.3
16 INT148775 Binding of Calca and Usf1 1 0.43 0.85 1.29
17 INT281373 Tcf21 Regulation of Fig4 1 0.03 0.67 1.2
18 INT281379 Tcf21 Regulation of FSCN1 1 0.01 0.66 1.19
19 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
20 INT167429 Negative_regulation of Mapk8 Negative_regulation of RYBP 1 0.01 1.11 1.09
21 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
22 INT223875 Negative_regulation of Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.31 0 1.07
23 INT119887 Binding of Atf4 and Usf1 1 0.21 0.15 1.05
24 INT119888 Binding of Creb1 and Usf1 1 0.18 0.15 1.05
25 INT134970 Positive_regulation of Binding of OPRK1 and SP1 1 0.00 0 1.05
26 INT134969 Binding of OPRK1 and SP1 1 0.00 0 1.04
27 INT54737 PPBP Regulation of NCOR2 1 0.01 0.15 1.01
28 INT316128 TCF21 Negative_regulation of Gene_expression of HLA-DRA 1 0.07 0.13 0.99
29 INT148772 Usf1 Regulation of Calca 1 0.40 0.69 0.95
30 INT77254 Binding of gr and Sp1 1 0.04 0.4 0.9
31 INT103611 Mdk Negative_regulation of Phosphorylation of Sp1 1 0.01 0.28 0.88
32 INT239533 Binding of MTNR1A and NCOR2 1 0.01 0.53 0.87
33 INT292987 SGCG Positive_regulation of NCOR2 1 0.00 0.29 0.87
34 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
35 INT97913 NCOR2 Regulation of ABAT 1 0.00 0 0.85
36 INT222024 Mapk8 Regulation of Mapk14 2 0.17 0.83 0.79
37 INT158684 MAPK8 Positive_regulation of Gene_expression of BCL2L11 1 0.51 0.44 0.78
38 INT306259 HDAC9 Negative_regulation of Gene_expression of TNF 1 0.21 0.89 0.78
39 INT152234 Mapk8 Positive_regulation of Localization of Nfkb1 1 0.33 0.26 0.78
40 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
41 INT306258 HDAC4 Negative_regulation of Gene_expression of TNF 1 0.09 0.89 0.78
42 INT56895 Binding of GNRH1 and NCOR2 1 0.02 0 0.76
43 INT98179 Aap Positive_regulation of Mapk8 1 0.01 0.75 0.74
44 INT168420 Positive_regulation of Mapk8 Positive_regulation of Phosphorylation of Jun 1 0.30 0.88 0.74
45 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 0.23 0.46 0.74
46 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
47 INT157539 Binding of SP1 and Regulation of Gene_expression of OPRM1 1 0.36 1.2 0.72
48 INT223873 Mapk8 Regulation of Positive_regulation of Ltp 1 0.24 0 0.71
49 INT98956 Positive_regulation of Binding of NR5A2 and SP1 1 0.00 0 0.7
50 INT207542 Sp1 Regulation of Oprm1 1 0.15 0.06 0.7
51 INT98958 Binding of NR5A2 and SP1 1 0.00 0 0.7
52 INT68561 Binding of Gli3 and Ust 1 0.01 0.68 0.68
53 INT223869 Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.20 0 0.68
54 INT207547 Sp1 Regulation of Qsox1 1 0.05 0.06 0.67
55 INT110458 Binding of Atf2 and Mapk8 1 0.35 0 0.66
56 INT330046 Mapk8 Negative_regulation of Prkcg 1 0.13 0.4 0.66
57 INT158685 ROS1 Regulation of Positive_regulation of MAPK8 1 0.21 0.39 0.64
58 INT100030 TNF Positive_regulation of Mapk8 1 0.12 1.57 0.63
59 INT169295 PTPLA Positive_regulation of MAPK8 1 0.10 0.15 0.63
60 INT123416 Gene_expression of Sp1 Positive_regulation of Oprm1 1 0.60 0 0.63
61 INT148780 Binding of Usf2 and Usf1 1 0.40 0.41 0.62
62 INT100369 HIF1A Positive_regulation of Positive_regulation of VEGFA 1 0.29 0.99 0.62
63 INT98953 Positive_regulation of Binding of SP1 and CFHR4 1 0.00 0 0.62
64 INT98954 Binding of SP1 and CFHR4 1 0.00 0 0.61
65 INT128812 Mapk8 Negative_regulation of Gene_expression of Nos2 1 0.19 0.37 0.61
66 INT148779 Usf1 Negative_regulation of Calca 1 0.44 0.4 0.59
67 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58
68 INT278689 TNF Positive_regulation of MAPK8 1 0.04 0.79 0.56
69 INT81267 Negative_regulation of Binding of MLN and NCOR2 1 0.02 0.28 0.56
70 INT222246 Binding of Ccr2 and Tcf21 1 0.29 0.67 0.55
71 INT222249 Positive_regulation of Binding of Ccr2 and Tcf21 1 0.39 0.67 0.55
72 INT281124 Tcf21 Positive_regulation of Binding of Ddc 1 0.04 1.21 0.54
73 INT281129 Tcf21 Positive_regulation of Binding of Cd4 1 0.04 1.21 0.54
74 INT281152 Tcf21 Positive_regulation of Binding of ITIH4 1 0.03 1.21 0.54
75 INT200913 Dio1 Positive_regulation of Mapk8 1 0.00 0 0.53
76 INT281131 Tcf21 Positive_regulation of Rent1 1 0.00 1.19 0.53
77 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
78 INT172248 Binding of KNG1 and NCOR2 1 0.02 0.19 0.52
79 INT281374 Tcf21 Positive_regulation of Gene_expression of Sds 1 0.03 0 0.51
80 INT81265 Binding of MLN and NCOR2 1 0.02 0.23 0.51
81 INT304578 Negative_regulation of HDAC9 Positive_regulation of Gene_expression of Bdnf 1 0.06 0.9 0.49
82 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
83 INT135176 Myst2 Regulation of Gene_expression of Hif1a 1 0.24 0.47 0.47
84 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46
85 INT70183 Binding of PRCP and NCOR2 1 0.04 0.08 0.46
86 INT254225 Mapk14 Positive_regulation of Mapk8 1 0.02 0.87 0.46
87 INT254198 Mapk1 Positive_regulation of Mapk8 1 0.01 0.87 0.46
88 INT227495 Regulation of Binding of TCEA1 and SIRT2 1 0.01 0.45 0.45
89 INT172238 Binding of NPBWR2 and NCOR2 1 0.01 0.27 0.44
90 INT135178 Myst2 Regulation of Hif1a 1 0.24 0.44 0.44
91 INT278950 MAPK8 Negative_regulation of Localization of EPHB2 1 0.25 0.47 0.43
92 INT264476 Il1a Positive_regulation of Gene_expression of Mapk8 1 0.04 0 0.43
93 INT172247 Binding of NCOR2 and QRFPR 1 0.01 0.12 0.43
94 INT116931 OPRK1 Regulation of MAPK8 1 0.31 0.07 0.43
95 INT264475 Il1a Positive_regulation of Mapk8 1 0.04 0 0.43
96 INT292634 IL4 Positive_regulation of Gene_expression of FOXP3 1 0.10 0.42 0.43
97 INT76154 Binding of NCOR2 and Negative_regulation of Localization of PLOD1 1 0.02 0 0.42
98 INT76153 Binding of NCOR2 and Negative_regulation of Localization of LHB 1 0.00 0 0.42
99 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
100 INT319312 Socs4 Positive_regulation of Mapk8 1 0.05 0.68 0.41
101 INT89332 Binding of SP1 and SP3 1 0.30 0.76 0.39
102 INT282820 Binding of TACR1 and NCOR2 1 0.00 0.88 0.39
103 INT339511 Binding of Tlr4 and Traf6 1 0.05 0.12 0.38
104 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38
105 INT179938 Negative_regulation of Mapk8 Negative_regulation of TNF 1 0.02 1.09 0.37
106 INT339506 Binding of Irak1 and Traf6 1 0.03 0.12 0.37
107 INT187233 Positive_regulation of Mapk8 Positive_regulation of Jun 1 0.12 0.92 0.37
108 INT264480 Il1a Positive_regulation of Phosphorylation of Mapk8 1 0.04 0 0.37
109 INT309120 Edc4 Negative_regulation of Positive_regulation of Mapk8 1 0.01 1.03 0.36
110 INT167558 Gene_expression of Sp1 Positive_regulation of Oprm1 1 0.03 0.07 0.36
111 INT308653 Proc Regulation of Gene_expression of Mapk8 1 0.00 1.48 0.36
112 INT200333 Binding of Rest and Sp1 1 0.24 0.07 0.35
113 INT200316 Sp1 Regulation of Gene_expression of Rest 1 0.31 0 0.35
114 INT330106 Racgap1 Positive_regulation of Positive_regulation of Mapk8 1 0.01 1.32 0.35
115 INT198647 TNF Positive_regulation of HIF1A 1 0.03 2.97 0.34
116 INT333893 Negative_regulation of HDAC9 Negative_regulation of Gene_expression of TNF 1 0.09 1.03 0.34
117 INT330105 Rac1 Positive_regulation of Mapk8 1 0.15 1.47 0.34
118 INT324690 Binding of Traf6 and Ticam1 2 0.07 0.23 0.33
119 INT75643 NCOR2 Positive_regulation of Positive_regulation of EIF2B3 1 0.00 0 0.33
120 INT330103 Rac1 Positive_regulation of Positive_regulation of Mapk8 1 0.14 1.24 0.32
121 INT108637 Binding of MC1R and NCOR2 1 0.00 0.1 0.32
122 INT203089 Binding of Il1a and Traf6 1 0.04 0.66 0.32
123 INT348016 Binding of Mapk8 and Mapk8ip3 1 0.04 2.09 0.32
124 INT203086 Positive_regulation of Binding of Il1a and Traf6 1 0.06 0.67 0.32
125 INT222251 Negative_regulation of Binding of Cxcl10 and Tcf21 1 0.23 0.34 0.32
126 INT110461 Binding of Mapk8 and Gtf3a 1 0.03 0 0.32
127 INT222247 Binding of Cxcl10 and Tcf21 1 0.20 0.34 0.32
128 INT282421 Mapk8 Negative_regulation of Ins1 1 0.06 2.48 0.31
129 INT253153 TNF Positive_regulation of Mapk8 1 0.18 0.61 0.31
130 INT167983 Mapk8 Negative_regulation of gr 1 0.02 0.5 0.31
131 INT253155 TNF Positive_regulation of Positive_regulation of Mapk8 1 0.19 0.62 0.31
132 INT200351 Sp1 Positive_regulation of Gene_expression of Rest 1 0.34 0.07 0.3
133 INT281127 Tcf21 Positive_regulation of Gene_expression of Cxcr4 1 0.08 0.42 0.3
134 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
135 INT56250 Binding of NBN and NCOR2 1 0.00 0 0.3
136 INT112795 Positive_regulation of CASP1 Positive_regulation of MAPK8 1 0.02 0.16 0.3
137 INT112803 CASP1 Positive_regulation of MAPK8 1 0.02 0.16 0.29
138 INT159964 Tnf Positive_regulation of Phosphorylation of Mapk8 1 0.11 0.94 0.29
139 INT226505 Il1rl1 Positive_regulation of Mapk8 1 0.04 0.4 0.29
140 INT226509 Il1rl1 Positive_regulation of Gene_expression of Mapk8 1 0.05 0.4 0.29
141 INT309122 Edc4 Positive_regulation of Phosphorylation of Mapk8 1 0.02 0.73 0.28
142 INT237679 IRF6 Positive_regulation of MAPK8 1 0.00 0.56 0.28
143 INT323710 TRAF6 Regulation of MIR146A 1 0.06 0.55 0.28
144 INT312894 Binding of Gsk3b and Positive_regulation of Gene_expression of Hdac6 1 0.08 1.3 0.27
145 INT172240 Binding of GPR37 and NCOR2 1 0.01 0 0.27
146 INT132368 Mapk8 Positive_regulation of Nfkb1 1 0.17 0.11 0.27
147 INT96789 Binding of SP1 and NR2F2 1 0.24 0.27 0.27
148 INT132369 Mapk8 Positive_regulation of Positive_regulation of Nfkb1 1 0.18 0.12 0.27
149 INT346957 HDAC9 Positive_regulation of Gene_expression of GSR 1 0.03 1.28 0.27
150 INT96787 SP1 Positive_regulation of GDF15 1 0.08 0.27 0.27
151 INT132366 Lgals1 Positive_regulation of Mapk8 1 0.38 0.13 0.27
152 INT132370 Mapk8 Positive_regulation of Ephb1 1 0.15 0.12 0.27
153 INT125515 SP1 Regulation of GDF15 1 0.14 0.47 0.26
154 INT179928 Binding of Ephb1 and Mapk8 1 0.11 0.91 0.26
155 INT169837 Sp1 Positive_regulation of Gene_expression of Kcnq3 1 0.04 0.08 0.26
156 INT171907 MAPK8 Positive_regulation of Gene_expression of MAPK14 1 0.06 0.77 0.26
157 INT126886 Protein_catabolism of SP1 Negative_regulation of Gene_expression of VEGFA 1 0.03 0.49 0.26
158 INT277613 Binding of HDAC9 and Runx2 1 0.02 0.59 0.26
159 INT169836 Sp1 Positive_regulation of Gene_expression of Kcnq2 1 0.05 0.08 0.26
160 INT171913 MAPK8 Positive_regulation of MAPK9 1 0.07 0.78 0.26
161 INT279278 NCOR2 Regulation of CDCP1 1 0.00 5.41 0.25
162 INT317773 Positive_regulation of GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
163 INT317775 GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
164 INT317771 GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
165 INT186783 Binding of ESR1 and NRIP1 1 0.31 0.79 0.25
166 INT260739 Mapk14 Regulation of Positive_regulation of Sp1 1 0.01 1.06 0.25
167 INT317776 Positive_regulation of GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
168 INT330053 Binding of Ros1 and Mapk8 1 0.02 0.88 0.24
169 INT333892 TNF Positive_regulation of Gene_expression of HDAC1 1 0.09 0.46 0.23
170 INT95741 Creb1 Regulation of Mapk8 1 0.39 0 0.23
171 INT292554 MAP3K5 Positive_regulation of MAPK8 1 0.08 0 0.23
172 INT97691 Binding of REST and HDAC9 1 0.26 0.09 0.23
173 INT254349 Positive_regulation of Binding of EPAS1 and HIF1A 1 0.00 0.92 0.23
174 INT309124 Dlat Negative_regulation of Positive_regulation of Mapk8 1 0.02 0.27 0.22
175 INT309116 Edc4 Negative_regulation of Mapk8 1 0.01 0.43 0.22
176 INT221781 Camk4 Positive_regulation of Mef2d 1 0.28 0.14 0.22
177 INT112802 IL4I1 Positive_regulation of Positive_regulation of MAPK8 1 0.04 0 0.22
178 INT162850 ISYNA1 Positive_regulation of Localization of HIF1A 1 0.05 0.25 0.21
179 INT88191 Binding of NCOR2 and ZAK 1 0.00 0.17 0.21
180 INT223828 Binding of GSTP1 and MAPK8 1 0.06 1.8 0.21
181 INT52459 Binding of SUCLA2 and HEY2 1 0.01 0.09 0.21
182 INT330051 Mapk8 Positive_regulation of Bcl2l11 1 0.13 0.46 0.21
183 INT189196 RASGRP1 Positive_regulation of SP1 1 0.05 0.63 0.21
184 INT45934 PKN1 Regulation of NOTCH2NL 1 0.01 0 0.2
185 INT297545 Pou3f3 Regulation of Hes1 1 0.05 0.41 0.2
186 INT45933 PKN1 Regulation of PKN3 1 0.05 0 0.2
187 INT186782 Binding of RARB and NRIP1 1 0.03 0.49 0.2
188 INT239536 Binding of CXCR2 and NCOR2 1 0.00 0 0.2
189 INT186781 Binding of NRIP1 and GOPC 1 0.05 0.49 0.2
190 INT131718 Mapk8 Regulation of Penk 1 0.46 0.16 0.2
191 INT266414 Binding of HMGB1 and Mapk8 1 0.03 0.91 0.2
192 INT301282 Tnfsf11 Positive_regulation of Traf6 1 0.10 0.65 0.2
193 INT136462 Negative_regulation of Ptgs1 Negative_regulation of Gene_expression of Sp1 1 0.01 0.65 0.19
194 INT179935 Binding of Jun and Mapk8 1 0.04 0.61 0.19
195 INT264189 HR Positive_regulation of Gene_expression of IL10 1 0.00 1.48 0.19
196 INT286965 Binding of STAT3 and FOXP3 1 0.27 1.84 0.19
197 INT209934 IL1B Positive_regulation of MAPK8 1 0.06 0.37 0.19
198 INT305003 HIF1A Regulation of SERPINE1 1 0.11 2.3 0.19
199 INT222023 Gpx3 Regulation of Mapk8 1 0.01 1.43 0.18
200 INT299370 Binding of Mapk8 and Life1 1 0.04 0.73 0.18

Single Events

The table below shows the top 100 pain related interactions that have been reported for histone deacetylase binding. They are ordered first by their pain relevance and then by number of times they were reported in histone deacetylase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
2 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98
3 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52
4 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2
5 INT6855 Binding of NCOR2 71 0.41 15.64 28.96
6 INT27933 Gene_expression of NCOR2 65 0.72 31.35 24.23
7 INT35716 Positive_regulation of NCOR2 45 0.60 18 23.54
8 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25
9 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9
10 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
11 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24
12 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86
13 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
14 INT41558 Localization of Sp1 9 0.48 0.56 14.9
15 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66
16 INT40478 Negative_regulation of NCOR2 23 0.48 12.77 14.56
17 INT95738 Positive_regulation of Phosphorylation of Mapk8 40 0.70 23.46 13.88
18 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
19 INT24082 Negative_regulation of Sp1 13 0.40 1.19 13.11
20 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65
21 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44
22 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4
23 INT145695 Regulation of Mapk8 26 0.62 14.67 9.83
24 INT215353 Gene_expression of Tcf21 16 0.59 9.71 9.49
25 INT155944 Gene_expression of Foxp3 66 0.66 24.37 9.12
26 INT111998 Positive_regulation of Positive_regulation of Mapk8 23 0.69 9.33 8.97
27 INT104481 Regulation of Mapk8 21 0.50 13.87 8.41
28 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4
29 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37
30 INT96912 Positive_regulation of Phosphorylation of Mapk8 29 0.69 18.33 8.14
31 INT29229 Regulation of NCOR2 20 0.42 5.75 8.08
32 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
33 INT99071 Positive_regulation of Gene_expression of Mapk8 16 0.55 9.87 7.58
34 INT48555 Binding of SP1 30 0.46 11.38 6.53
35 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36
36 INT135170 Positive_regulation of Hif1a 86 0.67 99.4 6.07
37 INT333909 Positive_regulation of Gene_expression of HDAC1 1 0.44 14.15 5.9
38 INT41604 Negative_regulation of Localization of Sp1 2 0.30 0.32 5.86
39 INT112713 Gene_expression of Hif1a 24 0.75 20.48 5.45
40 INT135172 Gene_expression of Hif1a 56 0.76 46.49 5.44
41 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42
42 INT128922 Negative_regulation of Gene_expression of Mapk8 6 0.34 3.93 5.36
43 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23
44 INT135291 Positive_regulation of Positive_regulation of Mapk8 24 0.64 19.37 5.16
45 INT97692 Positive_regulation of HDAC9 17 0.45 14.88 5.11
46 INT131717 Positive_regulation of Gene_expression of Mapk8 18 0.55 14.25 5.02
47 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93
48 INT72834 Negative_regulation of Tcf21 10 0.58 5.8 4.84
49 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28
50 INT112704 Positive_regulation of Hif1a 25 0.67 21.49 4.23
51 INT109935 Positive_regulation of Phosphorylation of MAPK8 35 0.68 13.13 4.18
52 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06
53 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94
54 INT123411 Gene_expression of Sp1 15 0.69 4.2 3.79
55 INT22566 Positive_regulation of Tcf21 8 0.65 3.06 3.75
56 INT21569 Binding of Mapk8 8 0.48 5.55 3.44
57 INT41559 Positive_regulation of Sp1 7 0.45 2.65 3.24
58 INT163529 Negative_regulation of Positive_regulation of Mapk8 14 0.43 8.37 3.2
59 INT137532 Negative_regulation of HEY2 1 0.31 1.69 3.18
60 INT123409 Binding of Sp1 20 0.39 3.18 3.15
61 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05
62 INT110755 Negative_regulation of Positive_regulation of Mapk8 15 0.46 9.91 2.98
63 INT103607 Binding of Sp1 7 0.42 1.26 2.92
64 INT281367 Regulation of Gene_expression of Tcf21 1 0.09 1.39 2.89
65 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88
66 INT93213 Phosphorylation of Sp1 5 0.67 0.93 2.84
67 INT95735 Regulation of Phosphorylation of Mapk8 7 0.50 1.88 2.69
68 INT134756 Positive_regulation of Gene_expression of Hif1a 8 0.50 11.14 2.68
69 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
70 INT95739 Negative_regulation of Phosphorylation of Mapk8 11 0.42 6.77 2.61
71 INT24902 Gene_expression of SP1 17 0.71 8.11 2.58
72 INT17039 Regulation of Hr 11 0.27 5.22 2.58
73 INT188344 Positive_regulation of Gene_expression of Foxp3 10 0.36 5.97 2.56
74 INT23998 Positive_regulation of Sp1 4 0.40 0.51 2.56
75 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48
76 INT29228 Negative_regulation of Binding of NCOR2 4 0.02 0.62 2.47
77 INT17037 Negative_regulation of Hr 11 0.22 11.81 2.46
78 INT281369 Negative_regulation of Gene_expression of Tcf21 1 0.08 1.4 2.44
79 INT103609 Transcription of Sp1 1 0.11 0.97 2.42
80 INT79917 Positive_regulation of Cir1 7 0.67 0 2.2
81 INT133648 Regulation of HDAC9 14 0.60 10.01 2.18
82 INT100381 Positive_regulation of Positive_regulation of HIF1A 12 0.49 12.05 2.17
83 INT109908 Localization of MAPK8 10 0.73 3.86 2.14
84 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13
85 INT103608 Negative_regulation of Binding of Sp1 4 0.35 0.69 2.1
86 INT87028 Positive_regulation of Positive_regulation of NCOR2 4 0.01 0.92 2.09
87 INT156270 Regulation of Positive_regulation of Mapk8 3 0.41 2.31 2.08
88 INT41495 Regulation of Sp1 7 0.42 2.96 2.05
89 INT41557 Gene_expression of Sp1 5 0.68 1.17 2.04
90 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02
91 INT90004 Gene_expression of TCF21 4 0.65 2.48 2.02
92 INT119803 Localization of Cir1 12 0.70 3.39 2
93 INT152696 Negative_regulation of Negative_regulation of Mapk8 1 0.32 0.35 2
94 INT221431 Negative_regulation of FOXP3 8 0.40 9.92 1.98
95 INT109313 Binding of Mapk8 6 0.48 1.78 1.98
96 INT96916 Negative_regulation of Phosphorylation of Mapk8 16 0.52 9.68 1.97
97 INT48850 Gene_expression of PKN1 16 0.52 1.93 1.92
98 INT180134 Gene_expression of SIRT2 70 0.11 6.95 1.84
99 INT191154 Binding of HDAC9 20 0.36 14.12 1.83
100 INT164864 Positive_regulation of Negative_regulation of Mapk8 1 0.31 1.33 1.82
101 INT277591 Gene_expression of Hdac4 22 0.77 7.77 1.79
102 INT24906 Negative_regulation of SP1 8 0.40 4.48 1.77
103 INT299365 Transcription of Mapk8 9 0.72 5.91 1.75
104 INT221426 Positive_regulation of Gene_expression of FOXP3 9 0.48 5.98 1.72
105 INT316162 Localization of TCF21 1 0.18 0.28 1.71
106 INT54738 Negative_regulation of Negative_regulation of NCOR2 2 0.37 1.01 1.7
107 INT122597 Transcription of Hif1a 5 0.69 5.56 1.63
108 INT168714 Negative_regulation of Binding of Mapk8 1 0.36 0.18 1.62
109 INT153723 Negative_regulation of Gene_expression of Hif1a 2 0.41 1.25 1.58
110 INT41605 Positive_regulation of Localization of Sp1 1 0.05 0 1.58
111 INT139009 Positive_regulation of Localization of Cir1 10 0.44 2.98 1.55
112 INT135171 Positive_regulation of Gene_expression of Hif1a 15 0.68 16.95 1.51
113 INT119048 Negative_regulation of Gene_expression of HIF1A 10 0.57 9.23 1.5
114 INT143443 Localization of HIF1A 14 0.78 10.93 1.49
115 INT167872 Negative_regulation of Gene_expression of Foxp3 8 0.50 4.14 1.46
116 INT140245 Binding of Gli3 3 0.36 2.65 1.46
117 INT168863 Regulation of Wdtc1 3 0.08 1.88 1.45
118 INT79918 Gene_expression of Cir1 2 0.65 0 1.45
119 INT54996 Regulation of KAT2B 1 0.19 0.38 1.45
120 INT332792 Positive_regulation of Gene_expression of HDAC9 5 0.45 4.61 1.44
121 INT222228 Positive_regulation of Gene_expression of Tcf21 4 0.38 0.84 1.39
122 INT123414 Transcription of Sp1 5 0.48 2.2 1.38
123 INT110485 Binding of Tcf21 2 0.36 0.76 1.37
124 INT333914 Transcription of HDAC1 1 0.34 3.04 1.37
125 INT190880 Binding of Ncor2 11 0.27 2.24 1.34
126 INT232785 Localization of Hif1a 8 0.46 10.37 1.33
127 INT119880 Binding of Usf1 5 0.20 2.55 1.28
128 INT94692 Positive_regulation of Gene_expression of Sp1 3 0.17 0.39 1.28
129 INT24000 Regulation of Sp1 2 0.22 1.25 1.27
130 INT125079 Negative_regulation of Gene_expression of MAPK8 9 0.39 4.87 1.25
131 INT277581 Positive_regulation of Hdac4 4 0.50 1.47 1.25
132 INT258053 Positive_regulation of Negative_regulation of HDAC9 8 0.27 7.37 1.23
133 INT316154 Positive_regulation of TCF21 4 0.17 1.22 1.23
134 INT154048 Negative_regulation of Gene_expression of Mapk8 5 0.43 4.43 1.22
135 INT298979 Gene_expression of Traf6 5 0.31 1.75 1.21
136 INT48554 Positive_regulation of SP1 12 0.49 3.64 1.2
137 INT137860 Positive_regulation of Hr 2 0.14 3.9 1.16
138 INT229562 Negative_regulation of Foxp3 6 0.36 3.7 1.14
139 INT93216 Negative_regulation of Phosphorylation of Sp1 2 0.14 0.4 1.13
140 INT260447 Binding of HDAC1 8 0.23 4.47 1.12
141 INT148765 Gene_expression of Usf1 1 0.77 0.72 1.12
142 INT332771 Phosphorylation of Tcf21 1 0.09 0.21 1.07
143 INT332772 Positive_regulation of Phosphorylation of Tcf21 1 0.06 0.21 1.07
144 INT102249 Binding of HIF1A 39 0.36 30.47 1.04
145 INT333907 Positive_regulation of HDAC1 4 0.32 3.07 1.03
146 INT234473 Gene_expression of HDAC4 8 0.18 6.28 0.99
147 INT211548 Gene_expression of Lpin1 9 0.76 12.83 0.96
148 INT123408 Positive_regulation of Gene_expression of Sp1 2 0.62 0.9 0.96
149 INT123407 Negative_regulation of Binding of Sp1 6 0.47 0.72 0.93
150 INT200272 Localization of Sp1 3 0.57 0.06 0.93
151 INT169235 Negative_regulation of USF1 4 0.37 2.69 0.91
152 INT102677 Negative_regulation of TCF21 2 0.41 0.22 0.89
153 INT180136 Localization of SIRT2 15 0.12 1.42 0.88
154 INT277586 Negative_regulation of Mef2c 36 0.59 11.03 0.86
155 INT200900 Localization of Mapk8 9 0.40 5.76 0.84
156 INT221427 Positive_regulation of FOXP3 6 0.45 2.74 0.83
157 INT155352 Phosphorylation of HIF1A 3 0.79 3.34 0.83
158 INT123410 Negative_regulation of Gene_expression of Sp1 3 0.38 1.01 0.82
159 INT157492 Transcription of Foxp3 4 0.61 1.69 0.81
160 INT100378 Protein_catabolism of HIF1A 7 0.96 5.05 0.8
161 INT81269 Negative_regulation of Positive_regulation of NCOR2 1 0.02 0.54 0.8
162 INT135169 Binding of Hif1a 22 0.47 12.48 0.79
163 INT29230 Regulation of Binding of NCOR2 2 0.08 0 0.79
164 INT48851 Positive_regulation of Gene_expression of PKN1 2 0.27 0.67 0.78
165 INT182293 Binding of MAPK8 11 0.34 4.6 0.77
166 INT165104 Negative_regulation of Negative_regulation of Mapk8 5 0.43 4.21 0.77
167 INT150251 Transcription of FOXP3 7 0.61 0.43 0.76
168 INT165105 Localization of Mapk8 7 0.69 4.45 0.76
169 INT84726 Gene_expression of NKX3-1 4 0.75 2.1 0.75
170 INT70423 Binding of HDAC3 1 0.01 0.36 0.75
171 INT284955 Localization of HDAC1 2 0.47 1.71 0.74
172 INT164489 Regulation of Gene_expression of Mapk8 2 0.44 0.65 0.74
173 INT169731 Negative_regulation of Localization of HIF1A 1 0.57 0.57 0.73
174 INT180139 Protein_catabolism of SIRT2 11 0.14 1.1 0.72
175 INT184694 Gene_expression of Usf1 10 0.55 4.27 0.72
176 INT237709 Negative_regulation of Negative_regulation of MAPK8 6 0.25 2.09 0.72
177 INT100380 Negative_regulation of Positive_regulation of HIF1A 2 0.57 1.6 0.72
178 INT179481 Positive_regulation of Wdtc1 8 0.67 7.11 0.71
179 INT251303 Binding of HR 14 0.47 3.87 0.7
180 INT221428 Negative_regulation of Negative_regulation of FOXP3 1 0.35 1.97 0.7
181 INT68560 Regulation of Gli3 3 0.18 1.51 0.68
182 INT202361 Gene_expression of Mef2c 28 0.78 5.53 0.67
183 INT128795 Regulation of Positive_regulation of HIF1A 2 0.61 0.95 0.67
184 INT98967 Localization of SP1 2 0.60 0.15 0.66
185 INT233837 Negative_regulation of Hif1a 9 0.26 12.72 0.65
186 INT24905 Negative_regulation of Gene_expression of SP1 4 0.39 2.05 0.65
187 INT112708 Negative_regulation of Hif1a 5 0.38 2.7 0.64
188 INT186790 Regulation of NRIP1 4 0.45 6.68 0.64
189 INT100382 Positive_regulation of Protein_catabolism of HIF1A 2 0.45 1.75 0.64
190 INT264709 Gene_expression of Hes1 24 0.76 7.04 0.63
191 INT297286 Positive_regulation of Foxp3 7 0.58 3.05 0.63
192 INT177936 Positive_regulation of Negative_regulation of MAPK8 3 0.50 2.1 0.63
193 INT312882 Negative_regulation of Hdac6 1 0.52 1.86 0.63
194 INT100377 Negative_regulation of Protein_catabolism of HIF1A 1 0.57 0.9 0.63
195 INT136465 Regulation of Hif1a 5 0.39 7.05 0.62
196 INT188799 Positive_regulation of Protein_catabolism of Traf6 2 0.19 1.98 0.62
197 INT17038 Negative_regulation of Regulation of Hr 1 0.05 0.17 0.62
198 INT148385 Positive_regulation of HEY2 1 0.38 1.09 0.62
199 INT112363 Regulation of Gene_expression of HIF1A 6 0.60 2.28 0.61
200 INT155353 Positive_regulation of Phosphorylation of HIF1A 1 0.49 2.58 0.61
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