GO:0042866

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Name pyruvate biosynthetic process
Categary Process
Go Slim No
Go Link GO:0042866
Unique Molecular Interactions 67
Total Molecular Interactions 97
Total Single Events 488
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for pyruvate biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for pyruvate biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT281382 FSCN1 Positive_regulation of Sds 1 0.02 0.84 1.33
2 INT147033 Positive_regulation of Binding of Sds and Accn3 1 0.13 0.73 1.23
3 INT147032 Binding of Sds and Accn3 1 0.09 0.73 1.22
4 INT98908 Binding of NTRK1 and PKLR 1 0.41 1.95 1.18
5 INT98906 Positive_regulation of Binding of NTRK1 and PKLR 1 0.56 1.95 1.18
6 INT199392 Pklr Positive_regulation of Prok2 1 0.34 1.3 0.91
7 INT199391 Pklr Positive_regulation of Prokr1 1 0.31 1.28 0.87
8 INT80793 Prkcg Regulation of Pkm2 1 0.29 0.2 0.83
9 INT288323 Glyr1 Regulation of Sds 1 0.05 0.2 0.72
10 INT288326 Sds Positive_regulation of Glyr1 1 0.10 0.12 0.68
11 INT199390 Pklr Regulation of Positive_regulation of Prokr1 1 0.18 0.89 0.68
12 INT288324 Sds Positive_regulation of Gene_expression of Glyr1 1 0.10 0.12 0.68
13 INT146375 Sds Negative_regulation of Positive_regulation of Cysltr1 1 0.02 0.32 0.67
14 INT281374 Tcf21 Positive_regulation of Gene_expression of Sds 1 0.03 0 0.51
15 INT326472 AGXT Negative_regulation of PGAP1 1 0.00 0.05 0.39
16 INT233513 Pklr Negative_regulation of Localization of Il10 1 0.04 1.12 0.39
17 INT265015 Pgr Positive_regulation of Sds 1 0.04 0.49 0.37
18 INT110834 Binding of AGXT and SPTLC2 2 0.27 0.71 0.36
19 INT288325 Binding of Glyr1 and Sds 1 0.07 0 0.3
20 INT63988 Cntf Regulation of Positive_regulation of Sds 1 0.22 0 0.28
21 INT233515 Pklr Positive_regulation of Gene_expression of Tnf 1 0.05 1.12 0.27
22 INT157211 Binding of AGXT and WNK1 1 0.07 0.68 0.22
23 INT157213 Binding of AGXT and SGCG 1 0.30 0.68 0.22
24 INT76865 Lmo4 Positive_regulation of Sds 1 0.02 0.38 0.2
25 INT76866 Negative_regulation of Lmo4 Positive_regulation of Sds 1 0.02 0.38 0.2
26 INT178704 GOPC Positive_regulation of Srr 1 0.02 0 0.16
27 INT178703 Regulation of GOPC Positive_regulation of Srr 1 0.02 0 0.16
28 INT190246 TARBP2 Positive_regulation of PKLR 1 0.01 0.41 0.1
29 INT292328 Binding of Sds and Mb 1 0.11 0.24 0.1
30 INT251389 Binding of Gabbr1 and Sds 1 0.23 0.32 0.1
31 INT283352 Binding of Srr and Bsn 1 0.14 0 0.08
32 INT233521 Binding of Pklr and Prokr1 1 0.17 0.44 0.07
33 INT145622 Binding of PKLR and UGT1A3 1 0.01 0 0.06
34 INT145623 Binding of PKLR and UGT2B4 1 0.02 0 0.06
35 INT145626 Binding of PKLR and UGT1A1 1 0.02 0 0.06
36 INT145621 Binding of PKLR and UGT2B7 1 0.02 0 0.06
37 INT145624 Binding of PKLR and UGT1A9 1 0.02 0 0.06
38 INT145625 Binding of PKLR and UGT2B17 1 0.01 0 0.06
39 INT292334 Binding of Sds and Fig4 1 0.02 0.07 0.05
40 INT204387 Binding of Napa and Sds 1 0.00 0 0.05
41 INT190247 TARBP2 Negative_regulation of PKLR 1 0.01 0.2 0.05
42 INT329849 PPARA Regulation of AGXT 1 0.03 0.06 0.04
43 INT283344 Regulation of Binding of Srr and Bsn 1 0.08 0 0.04
44 INT329848 PPARA Regulation of Localization of AGXT 1 0.03 0.06 0.04
45 INT226813 Binding of Srr and Positive_regulation of IFN1@ 1 0.33 0.82 0.03
46 INT283360 Binding of Ctbp2 and Srr 1 0.10 0 0.03
47 INT283346 Binding of Srr and Kif3a 1 0.17 0 0
48 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
49 INT283358 Binding of Srr and Erc1 1 0.00 0.07 0
50 INT283349 Srr Positive_regulation of Gene_expression of Erc1 1 0.26 0 0
51 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
52 INT283353 Srr Positive_regulation of Rims2 1 0.14 0 0
53 INT292329 Binding of Sds and LOC360919 1 0.01 0.08 0
54 INT347353 Binding of Ldha and Sds 1 0.12 0.07 0
55 INT283357 Srr Positive_regulation of Rims1 1 0.12 0 0
56 INT283350 Srr Positive_regulation of Gene_expression of Rims2 1 0.14 0 0
57 INT283356 Srr Positive_regulation of Gene_expression of Rims1 1 0.12 0 0
58 INT232364 Bgn Negative_regulation of Agxt 1 0.02 0.65 0
59 INT110836 Binding of AGXT and SPTLC1 1 0.30 0.11 0
60 INT283351 Binding of Srr and Fig4 1 0.04 0 0
61 INT347352 Negative_regulation of Binding of Ldha and Sds 1 0.14 0.07 0
62 INT283355 Srr Positive_regulation of Erc1 1 0.11 0 0
63 INT283343 Binding of Srr and Pclo 1 0.05 0 0
64 INT283347 Binding of Srr and Ctbp1 1 0.13 0 0
65 INT301639 Positive_regulation of Mlxipl Positive_regulation of Gene_expression of Pklr 1 0.03 0.52 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for pyruvate biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in pyruvate biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT19948 Gene_expression of Sds 34 0.63 14.69 15.44
2 INT3969 Positive_regulation of Sds 27 0.69 7.52 12.31
3 INT53685 Regulation of Sds 10 0.39 5.39 7.22
4 INT29845 Positive_regulation of Sds 11 0.62 3.69 6.63
5 INT93387 Gene_expression of Sds 9 0.65 2.58 5.72
6 INT1317 Negative_regulation of Sds 23 0.48 6.97 5.03
7 INT35990 Negative_regulation of Sds 8 0.49 4.47 4.96
8 INT131176 Gene_expression of Srr 8 0.64 3.29 4.81
9 INT35992 Regulation of Sds 7 0.52 1.14 4.04
10 INT131178 Positive_regulation of Srr 4 0.56 4.78 3.91
11 INT35634 Positive_regulation of Gene_expression of Sds 10 0.37 3.23 3.69
12 INT153108 Transcription of Srr 4 0.57 1.41 2.38
13 INT281368 Regulation of Gene_expression of Sds 3 0.13 1.66 2.31
14 INT131177 Regulation of Gene_expression of Srr 3 0.51 0.4 2.22
15 INT265010 Negative_regulation of Gene_expression of Sds 4 0.20 1.07 1.69
16 INT131179 Positive_regulation of Gene_expression of Srr 4 0.57 0.87 1.63
17 INT110838 Regulation of AGXT 5 0.46 2.21 1.28
18 INT153106 Regulation of Transcription of Srr 1 0.37 0 1.25
19 INT76864 Negative_regulation of Positive_regulation of Sds 2 0.43 0.62 1.21
20 INT86670 Negative_regulation of AGXT 6 0.57 2.24 1.18
21 INT153111 Positive_regulation of Transcription of Srr 2 0.41 1.41 1.15
22 INT126706 Transcription of Sds 3 0.36 0.59 1.14
23 INT251387 Binding of Sds 1 0.27 0.46 1.12
24 INT72526 Regulation of Regulation of Sds 1 0.26 0.78 1.1
25 INT229787 Gene_expression of AGXT 4 0.16 0.94 1.08
26 INT60286 Gene_expression of PKLR 5 0.65 2.14 1.04
27 INT120408 Localization of PKLR 1 0.01 0.8 0.99
28 INT171406 Gene_expression of Pklr 3 0.65 2.75 0.86
29 INT152919 Localization of Sds 2 0.42 0.69 0.83
30 INT92862 Positive_regulation of Pklr 1 0.02 0.06 0.83
31 INT157073 Positive_regulation of PKLR 6 0.36 5.48 0.69
32 INT91744 Positive_regulation of Positive_regulation of Sds 1 0.22 0.17 0.59
33 INT265007 Positive_regulation of Phosphorylation of Sds 1 0.30 0.52 0.54
34 INT60289 Negative_regulation of PKLR 5 0.21 1.75 0.53
35 INT265009 Phosphorylation of Sds 1 0.36 0.51 0.53
36 INT152918 Transcription of Sds 1 0.33 0.49 0.53
37 INT120399 Positive_regulation of Phosphorylation of PKLR 1 0.01 0.44 0.53
38 INT120389 Phosphorylation of PKLR 2 0.11 1.81 0.51
39 INT63985 Negative_regulation of Negative_regulation of Sds 2 0.40 0.8 0.48
40 INT265005 Localization of Sds 4 0.35 1.15 0.47
41 INT196697 Binding of Srr 13 0.22 8.01 0.45
42 INT265008 Regulation of Transcription of Sds 1 0.20 0.23 0.44
43 INT186121 Gene_expression of Agxt 6 0.65 2.77 0.39
44 INT41270 Localization of Srr 4 0.68 2.08 0.39
45 INT60287 Regulation of PKLR 1 0.15 0.32 0.35
46 INT140349 Positive_regulation of Localization of Pklr 1 0.01 0.38 0.33
47 INT140352 Localization of Pklr 1 0.02 0.38 0.33
48 INT178687 Regulation of Srr 2 0.19 0.07 0.32
49 INT19360 Positive_regulation of AGXT 2 0.69 1.4 0.32
50 INT326486 Negative_regulation of Gene_expression of AGXT 2 0.08 0.41 0.32
51 INT74709 Positive_regulation of Agxt 1 0.12 0.62 0.29
52 INT121077 Binding of Sds 20 0.25 1.41 0.28
53 INT60288 Regulation of Gene_expression of PKLR 1 0.15 0.32 0.28
54 INT63987 Regulation of Positive_regulation of Sds 1 0.41 0 0.28
55 INT226794 Gene_expression of Srr 4 0.40 0.52 0.24
56 INT229790 Regulation of Gene_expression of AGXT 1 0.11 0.47 0.24
57 INT320582 Localization of Agxt 1 0.07 0 0.23
58 INT100440 Negative_regulation of Positive_regulation of AGXT 1 0.02 0.23 0.23
59 INT125877 Binding of PKLR 2 0.04 0.26 0.22
60 INT157220 Negative_regulation of Binding of AGXT 1 0.28 0.7 0.19
61 INT157217 Binding of AGXT 1 0.23 0.69 0.19
62 INT320579 Negative_regulation of Agxt 1 0.04 0 0.12
63 INT320580 Negative_regulation of Gene_expression of Agxt 1 0.04 0.1 0.11
64 INT226797 Positive_regulation of Srr 3 0.30 1.05 0.08
65 INT226796 Transcription of Srr 1 0.41 0.22 0.08
66 INT226798 Negative_regulation of Binding of Srr 1 0.25 0.32 0.08
67 INT225962 Regulation of Srr 1 0.02 0.22 0.07
68 INT251378 Negative_regulation of Binding of Sds 1 0.24 0 0.07
69 INT288314 Regulation of Gene_expression of Sds 1 0.28 0 0.06
70 INT226795 Negative_regulation of Srr 2 0.25 0.94 0.04
71 INT290912 Positive_regulation of Pkm2 1 0.10 0.14 0.04
72 INT329885 Positive_regulation of Localization of AGXT 1 0.05 0.06 0.04
73 INT329891 Localization of AGXT 1 0.07 0.06 0.04
74 INT290924 Negative_regulation of Gene_expression of Pkm2 1 0.06 0.08 0.03
75 INT290921 Gene_expression of Pkm2 1 0.10 0.08 0.03
76 INT232361 Positive_regulation of Gene_expression of Agxt 3 0.49 0.11 0
77 INT82996 Transcription of PKLR 2 0.51 0.6 0
78 INT283337 Phosphorylation of Srr 1 0.37 0 0
79 INT347351 Negative_regulation of Binding of Sds 1 0.20 0.07 0
80 INT330341 Positive_regulation of Gene_expression of PKLR 1 0.08 1.13 0
81 INT345394 Binding of Srr 1 0.27 0 0
82 INT290919 Regulation of Pkm2 1 0.04 0 0
83 INT328748 Positive_regulation of Binding of Sds 1 0.25 0.16 0
84 INT268247 Regulation of Binding of Srr 1 0.14 0.91 0
85 INT319097 Negative_regulation of Transcription of PKLR 1 0.05 0.24 0
86 INT288318 Positive_regulation of Gene_expression of Sds 1 0.36 0 0
87 INT301550 Positive_regulation of Gene_expression of Pklr 1 0.13 0.51 0
88 INT319098 Protein_catabolism of PKLR 1 0.13 0.49 0
89 INT290925 Negative_regulation of Pkm2 1 0.06 0 0
90 INT293467 Regulation of Gene_expression of Agxt 1 0.04 0 0
91 INT330349 Negative_regulation of Gene_expression of PKLR 1 0.07 1.23 0
92 INT292351 Regulation of Binding of Sds 1 0.13 0 0
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