GO:0042923

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Name neuropeptide binding
Categary Function
Go Slim No
Go Link GO:0042923
Unique Molecular Interactions 92
Total Molecular Interactions 124
Total Single Events 885
Pain Genes Associated 19

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for neuropeptide binding. They are ordered first by their pain relevance and then by number of times they were reported for neuropeptide binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT138777 Binding of Galr2 and Galr1 1 0.08 1.18 1.64
2 INT81788 Binding of AGRP and MC4R 4 0.51 0 1.09
3 INT331108 Mc1r Positive_regulation of Mc4r 1 0.44 1.05 1.06
4 INT113743 Mc3r Regulation of Gene_expression of Agrp 1 0.05 0.9 0.98
5 INT337899 Positive_regulation of MC3R Positive_regulation of Gene_expression of Bdnf 1 0.31 0 0.87
6 INT122687 Binding of Galr2 and Th 1 0.13 0.07 0.83
7 INT122688 Binding of Galr1 and Th 1 0.14 0.07 0.83
8 INT78348 Binding of GALR1 and GAL 4 0.41 1.47 0.8
9 INT92974 Creb1 Regulation of Positive_regulation of Galr1 1 0.32 0 0.57
10 INT13978 Grpr Positive_regulation of Localization of Sst 1 0.23 0 0.55
11 INT13981 Gast Positive_regulation of Localization of Grpr 1 0.23 0 0.55
12 INT108021 Binding of Pomc and Mc4r 1 0.00 0.97 0.55
13 INT214160 Binding of Lep and Mc4r 1 0.29 1.31 0.53
14 INT214164 Binding of Mc4r and Pomc 1 0.39 1.31 0.53
15 INT7403 Positive_regulation of Grpr Positive_regulation of Localization of Gast 1 0.09 0 0.53
16 INT150243 POMC Positive_regulation of Mc3r 1 0.05 0.88 0.52
17 INT89187 Agrp Negative_regulation of Mc3r 1 0.33 0 0.51
18 INT89186 Agrp Negative_regulation of Mc4r 1 0.40 0 0.51
19 INT130335 Binding of Mc4r and Nr3c2 1 0.06 1.87 0.5
20 INT355687 Art2b Positive_regulation of Gene_expression of Mc3r 1 0.02 1.01 0.48
21 INT31844 Grpr Regulation of Localization of Prl 1 0.04 0.37 0.47
22 INT32549 Grpr Positive_regulation of Regulation of Nts 1 0.03 0 0.41
23 INT55428 Grpr Positive_regulation of Localization of Calca 1 0.02 0 0.39
24 INT55427 Grpr Positive_regulation of Localization of Glp1r 1 0.02 0 0.38
25 INT214140 Agrp Positive_regulation of Mc3r 1 0.34 0.23 0.37
26 INT214158 Binding of Agrp and Mc3r 1 0.35 0.18 0.37
27 INT214142 Agrp Positive_regulation of Mc4r 1 0.39 0.23 0.37
28 INT214145 Binding of Agrp and Mc4r 1 0.40 0.18 0.37
29 INT31843 Grpr Negative_regulation of Localization of Prl 1 0.03 0.34 0.34
30 INT214157 Positive_regulation of Mc3r Regulation of Npy 1 0.14 0.49 0.33
31 INT75042 Binding of MC2R and MC4R 1 0.00 0.18 0.3
32 INT75041 Binding of MC2R and MC3R 1 0.01 0.18 0.3
33 INT120683 Galr1 Positive_regulation of Gal 1 0.37 0 0.28
34 INT185531 Binding of GRPR and NMBR 1 0.03 0 0.28
35 INT101040 Binding of MC3R and POMC 1 0.30 0.35 0.25
36 INT8325 Grpr Regulation of Localization of LH 1 0.08 0 0.24
37 INT337892 Positive_regulation of Mc4r Positive_regulation of Gene_expression of Nr2f2 1 0.34 0 0.23
38 INT8321 Fshr Regulation of Grpr 1 0.09 0 0.23
39 INT89158 Grpr Positive_regulation of Localization of Insr 1 0.02 0 0.23
40 INT224904 Binding of GALR2 and GAL 1 0.16 0.37 0.22
41 INT146826 Binding of Galr1 and Gtpbp4 1 0.03 0.17 0.22
42 INT79756 Binding of Gal and Galr2 1 0.34 0.07 0.21
43 INT78349 Binding of GALR1 and TUBB 1 0.39 0 0.21
44 INT8315 LH Regulation of Grpr 1 0.13 0 0.2
45 INT8307 Gnrh1 Regulation of Grpr 1 0.07 0 0.2
46 INT8302 Grpr Regulation of Grp 1 0.06 0 0.2
47 INT8310 Grpr Regulation of LH 1 0.08 0 0.2
48 INT273048 Adcyap1 Positive_regulation of Adcyap1r1 1 0.11 1.02 0.19
49 INT8324 Grpr Regulation of Rgn 1 0.00 0 0.19
50 INT210862 Binding of POMC and Mc4r 1 0.34 0.42 0.17
51 INT31842 Grpr Regulation of Prl 1 0.02 0.17 0.17
52 INT328999 POMC Positive_regulation of Mc3r 1 0.16 0 0.16
53 INT329002 POMC Positive_regulation of Mc4r 1 0.13 0 0.16
54 INT349850 Gfra1 Negative_regulation of Adcyap1r1 1 0.15 0.36 0.15
55 INT155084 Kiss1 Positive_regulation of Kiss1r 1 0.66 0.13 0.15
56 INT349851 Gfra3 Negative_regulation of Adcyap1r1 1 0.28 0.31 0.15
57 INT349849 Gfra2 Negative_regulation of Adcyap1r1 1 0.33 0.31 0.15
58 INT324560 Binding of Kiss1r and Kiss1 1 0.35 0 0.14
59 INT111284 AGRP Negative_regulation of MC4R 1 0.46 0 0.14
60 INT349758 Gal Positive_regulation of Galr1 1 0.37 0.44 0.14
61 INT337900 Ins1 Regulation of MC3R 1 0.12 0.07 0.12
62 INT315388 Binding of Adcyap1r1 and Adcyap1 1 0.02 0.5 0.12
63 INT111283 Regulation of Binding of AGRP and MC4R 1 0.48 0 0.12
64 INT214150 Binding of Mc3r and Msx1 1 0.03 0.5 0.12
65 INT111285 Positive_regulation of Binding of AGRP and MC4R 1 0.50 0 0.12
66 INT339251 KISS1R Regulation of GNRH1 1 0.28 0.23 0.12
67 INT214152 Binding of Mc4r and Msx1 1 0.03 0.24 0.11
68 INT214161 Pomc Regulation of Mc4r 1 0.21 0.1 0.09
69 INT329000 Binding of POMC and Mc4r 1 0.19 0 0.08
70 INT160730 Galr2 Regulation of Localization of Ins1 1 0.06 0 0.08
71 INT337898 Positive_regulation of MC3R Regulation of Gene_expression of Nr2f2 1 0.30 0 0.08
72 INT272774 Binding of Mc4r and Fto 1 0.30 0.66 0.08
73 INT83587 Binding of MC4R and Trh 1 0.01 0.19 0.07
74 INT83588 Binding of MC3R and Trh 1 0.28 0.19 0.07
75 INT190750 Adcyap1 Regulation of Positive_regulation of Adcyap1r1 1 0.11 0 0.06
76 INT224906 Binding of GALR2 and B4GALNT2 1 0.11 0 0
77 INT274215 Mc3r Positive_regulation of Gene_expression of Gsr 1 0.14 0.27 0
78 INT310188 Binding of Adcyap1r1 and Smad7 1 0.00 0 0
79 INT312663 DSE Positive_regulation of Regulation of MC4R 1 0.37 0 0
80 INT274216 Mc3r Regulation of Gene_expression of Gsr 1 0.08 0.27 0
81 INT310190 Binding of Adcyap1r1 and Smad6 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for neuropeptide binding. They are ordered first by their pain relevance and then by number of times they were reported in neuropeptide binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT64442 Regulation of Mc4r 6 0.62 5.22 19.09
2 INT64447 Transcription of Mc4r 14 0.61 6.08 15.29
3 INT64445 Gene_expression of Mc4r 17 0.78 5.06 12.91
4 INT89248 Positive_regulation of Galr1 14 0.70 6.99 12.3
5 INT89181 Gene_expression of Mc3r 33 0.77 22.48 11.85
6 INT85017 Positive_regulation of Mc4r 13 0.67 7.56 10.86
7 INT122682 Gene_expression of Galr2 11 0.63 5.06 10.77
8 INT89184 Gene_expression of Mc4r 55 0.77 23.85 10.65
9 INT64449 Negative_regulation of Gene_expression of Mc4r 7 0.58 2 7.86
10 INT51164 Gene_expression of Galr1 12 0.78 6.3 7.3
11 INT64444 Negative_regulation of Mc4r 9 0.58 5.12 6.44
12 INT122680 Positive_regulation of Gene_expression of Galr2 5 0.56 2.75 6.29
13 INT89247 Transcription of Galr1 7 0.72 3.38 5.61
14 INT68860 Gene_expression of Galr2 10 0.76 3.37 5.49
15 INT105609 Negative_regulation of Mc4r 10 0.58 10.4 5.04
16 INT105608 Positive_regulation of Mc3r 9 0.68 8.53 4.83
17 INT64446 Negative_regulation of Transcription of Mc4r 4 0.43 1.01 4.8
18 INT152580 Regulation of Gene_expression of Galr2 1 0.50 2.65 4.63
19 INT64441 Regulation of Transcription of Mc4r 3 0.27 2.93 4.62
20 INT63651 Gene_expression of Adcyap1r1 17 0.77 2.57 4.58
21 INT89251 Positive_regulation of Transcription of Galr1 4 0.50 0.25 4.37
22 INT64448 Gene_expression of Mc3r 7 0.74 3.27 4.3
23 INT111512 Negative_regulation of Galr1 4 0.59 6.45 3.61
24 INT120260 Positive_regulation of Galr2 7 0.69 2.33 3.47
25 INT89252 Regulation of Galr1 4 0.62 4.27 3.31
26 INT66599 Gene_expression of MC4R 16 0.78 12.37 3.12
27 INT51154 Gene_expression of Grpr 10 0.69 1.77 3.12
28 INT210838 Positive_regulation of Mc4r 17 0.53 6.79 3.06
29 INT130028 Positive_regulation of Gene_expression of Mc4r 2 0.45 0.41 2.7
30 INT112393 Positive_regulation of Galr1 8 0.69 2.36 2.58
31 INT122681 Binding of Galr2 3 0.35 0.78 2.56
32 INT112395 Gene_expression of Galr1 8 0.77 1.64 2.51
33 INT152163 Positive_regulation of GALR2 4 0.70 3.69 2.43
34 INT210833 Regulation of Mc4r 4 0.30 1.57 2.38
35 INT92973 Binding of Galr1 2 0.37 0.16 2.35
36 INT89249 Positive_regulation of Positive_regulation of Galr1 2 0.47 0.08 2.35
37 INT133681 Positive_regulation of Gene_expression of Mc3r 5 0.67 5.38 2.19
38 INT13974 Localization of Grpr 6 0.35 1.05 2.14
39 INT214122 Negative_regulation of Mc3r 5 0.43 3.59 2.14
40 INT138776 Positive_regulation of Galr2 3 0.56 2.24 1.86
41 INT101875 Binding of MC4R 6 0.47 0.19 1.73
42 INT7399 Positive_regulation of Grpr 5 0.59 0.35 1.7
43 INT113897 Positive_regulation of Transcription of Mc4r 1 0.45 0 1.7
44 INT193415 Positive_regulation of GALR1 1 0.36 2.27 1.66
45 INT178264 Positive_regulation of Gene_expression of Mc4r 10 0.43 3.52 1.57
46 INT92934 Gene_expression of GRPR 2 0.67 5.13 1.57
47 INT92972 Positive_regulation of Gene_expression of Galr1 2 0.69 0.08 1.46
48 INT214111 Localization of Mc3r 2 0.72 1.81 1.34
49 INT152167 Regulation of GALR2 2 0.44 2.23 1.33
50 INT214131 Regulation of Mc3r 2 0.52 1.43 1.24
51 INT75053 Gene_expression of MC3R 4 0.53 0.41 1.16
52 INT152579 Regulation of Gene_expression of Galr2 1 0.08 0.86 1.13
53 INT125147 Binding of Mc4r 10 0.41 3.55 1.08
54 INT331098 Negative_regulation of Positive_regulation of Mc4r 1 0.32 1.08 1.07
55 INT75846 Positive_regulation of MC4R 7 0.70 5.73 1.05
56 INT274205 Regulation of Gene_expression of Mc3r 2 0.43 1.96 1.03
57 INT335619 Positive_regulation of MC3R 2 0.67 0.42 1.03
58 INT113735 Negative_regulation of Gene_expression of Mc3r 2 0.39 0.9 0.98
59 INT113738 Regulation of Gene_expression of Mc3r 1 0.03 0.9 0.98
60 INT113736 Negative_regulation of Positive_regulation of Mc4r 1 0.08 1.11 0.93
61 INT36584 Binding of Grpr 3 0.32 0.11 0.89
62 INT71970 Positive_regulation of Adcyap1r1 6 0.14 0.49 0.84
63 INT109108 Transcription of Mc3r 2 0.61 0.78 0.82
64 INT193417 Localization of GALR2 1 0.74 0.83 0.8
65 INT111289 Regulation of MC4R 4 0.43 1 0.78
66 INT52373 Positive_regulation of Adcyap1r1 1 0.00 0.3 0.78
67 INT85018 Positive_regulation of Positive_regulation of Mc4r 3 0.24 0.11 0.76
68 INT79754 Binding of Galr2 3 0.48 0.59 0.72
69 INT78351 Gene_expression of GALR1 2 0.77 1.03 0.7
70 INT109580 Positive_regulation of Mc3r 2 0.48 1.09 0.69
71 INT92969 Positive_regulation of Binding of Galr1 1 0.50 0 0.63
72 INT136139 Transcription of Mc4r 4 0.70 1.83 0.62
73 INT92935 Binding of GRPR 2 0.32 1.99 0.62
74 INT77502 Regulation of GALR1 2 0.27 1.03 0.6
75 INT190734 Transcription of Adcyap1r1 1 0.19 0.1 0.6
76 INT60340 Positive_regulation of Gene_expression of Grpr 1 0.05 0.64 0.59
77 INT92970 Regulation of Gene_expression of Galr1 1 0.62 0 0.59
78 INT231014 Negative_regulation of MC4R 4 0.43 5.52 0.58
79 INT95975 Regulation of Galr2 2 0.54 0.42 0.55
80 INT92968 Regulation of Transcription of Galr1 1 0.27 0 0.55
81 INT155080 Gene_expression of Kiss1r 4 0.63 0.69 0.54
82 INT135979 Regulation of Gene_expression of GALR1 1 0.61 0.94 0.53
83 INT210835 Phosphorylation of Mc4r 1 0.51 0.06 0.52
84 INT210837 Localization of Mc4r 5 0.73 0.87 0.51
85 INT349753 Negative_regulation of Transcription of Galr1 1 0.59 1.88 0.51
86 INT172305 Binding of KISS1R 1 0.05 0.3 0.5
87 INT172300 Positive_regulation of KISS1R 1 0.06 0.3 0.49
88 INT131627 Binding of Galr1 3 0.48 0.51 0.47
89 INT355682 Negative_regulation of Positive_regulation of Mc3r 1 0.41 1.04 0.47
90 INT147563 Positive_regulation of Gene_expression of Galr2 1 0.13 0 0.46
91 INT8286 Regulation of Grpr 2 0.14 0.05 0.42
92 INT214095 Binding of Mc3r 1 0.32 0.67 0.41
93 INT2018 Regulation of Adcyap1r1 2 0.44 0.3 0.4
94 INT339257 Gene_expression of KISS1R 1 0.73 0.62 0.38
95 INT126808 Localization of Mc4r 2 0.36 1.13 0.35
96 INT55424 Positive_regulation of Localization of Grpr 1 0.02 0 0.34
97 INT53035 Negative_regulation of Grpr 3 0.43 0.47 0.33
98 INT214121 Regulation of Positive_regulation of Mc3r 1 0.33 0.49 0.33
99 INT190725 Regulation of Gene_expression of Adcyap1r1 1 0.13 0 0.32
100 INT355683 Regulation of Localization of Mc3r 1 0.43 0.3 0.31
101 INT312681 Negative_regulation of Gene_expression of MC4R 1 0.35 0.15 0.31
102 INT214102 Positive_regulation of Transcription of Mc4r 1 0.49 0.4 0.3
103 INT185607 Localization of GRPR 1 0.37 0 0.29
104 INT349756 Regulation of Galr2 1 0.23 1.94 0.26
105 INT63649 Positive_regulation of Gene_expression of Adcyap1r1 1 0.03 0.1 0.26
106 INT2017 Negative_regulation of Regulation of Adcyap1r1 1 0.41 0 0.25
107 INT89157 Negative_regulation of Localization of Grpr 1 0.02 0 0.23
108 INT337877 Positive_regulation of Positive_regulation of Mc4r 1 0.33 0 0.23
109 INT214129 Negative_regulation of Gene_expression of Mc3r 1 0.36 0.21 0.23
110 INT337883 Positive_regulation of Positive_regulation of MC3R 1 0.49 0.37 0.22
111 INT127657 Regulation of Galr1 1 0.60 0.17 0.21
112 INT349752 Positive_regulation of Negative_regulation of Galr1 1 0.50 1.37 0.2
113 INT146825 Negative_regulation of Positive_regulation of Galr2 1 0.42 0.17 0.19
114 INT257502 Binding of MC3R 3 0.36 0.98 0.18
115 INT316205 Negative_regulation of Binding of MC3R 1 0.41 0.89 0.18
116 INT81431 Negative_regulation of Positive_regulation of Grpr 1 0.02 0.07 0.18
117 INT75847 Regulation of Positive_regulation of MC4R 1 0.35 0.83 0.18
118 INT109583 Binding of Mc3r 1 0.34 0.22 0.18
119 INT109579 Binding of Mc4r 1 0.36 0.22 0.18
120 INT155082 Negative_regulation of Kiss1r 1 0.48 0.19 0.17
121 INT279930 Gene_expression of GALR2 3 0.60 0.6 0.16
122 INT316201 Regulation of Transcription of Mc4r 1 0.43 0.64 0.16
123 INT349757 Localization of Galr1 1 0.75 1.15 0.16
124 INT120680 Positive_regulation of Gene_expression of Galr1 1 0.50 0 0.15
125 INT155077 Regulation of Gene_expression of Kiss1r 1 0.50 0.17 0.15
126 INT349755 Negative_regulation of Gene_expression of Galr1 1 0.43 1.26 0.14
127 INT69352 Regulation of Binding of Grpr 1 0.14 0.05 0.14
128 INT111286 Positive_regulation of Binding of MC4R 1 0.47 0 0.13
129 INT210839 Regulation of Positive_regulation of Mc4r 1 0.37 0.2 0.11
130 INT112396 Positive_regulation of Positive_regulation of Galr1 1 0.48 0.16 0.08
131 INT214109 Regulation of Binding of Mc4r 1 0.39 0.78 0.08
132 INT214118 Positive_regulation of Binding of Mc4r 1 0.43 1.01 0.08
133 INT136134 Negative_regulation of Gene_expression of Mc4r 2 0.35 0.64 0.07
134 INT111288 Regulation of Binding of MC4R 1 0.22 0 0.06
135 INT261202 Regulation of MC3R 2 0.05 0.09 0.05
136 INT112394 Transcription of Galr1 1 0.51 0.55 0.05
137 INT214124 Negative_regulation of Binding of Mc4r 1 0.42 0.19 0.05
138 INT214107 Negative_regulation of Binding of Mc3r 1 0.36 0.19 0.05
139 INT335615 Regulation of Regulation of MC3R 1 0.05 0.09 0.05
140 INT335618 Positive_regulation of Gene_expression of MC4R 1 0.13 0.08 0.05
141 INT136138 Regulation of Gene_expression of Mc4r 1 0.25 0.64 0.04
142 INT202858 Regulation of Adcyap1r1 1 0.05 0.06 0.04
143 INT349847 Negative_regulation of Adcyap1r1 1 0.42 0.32 0.04
144 INT316200 Regulation of Negative_regulation of Mc4r 1 0.43 1.05 0.03
145 INT141377 Transcription of MC4R 2 0.65 0.25 0
146 INT224909 Binding of GALR1 1 0.31 0 0
147 INT125148 Positive_regulation of Negative_regulation of Mc4r 1 0.50 0 0
148 INT312671 Regulation of Transcription of MC4R 1 0.43 0.1 0
149 INT312675 Positive_regulation of Positive_regulation of MC4R 1 0.44 0 0
150 INT310175 Binding of Adcyap1r1 1 0.02 0 0
151 INT141376 Transcription of MC3R 1 0.40 0.16 0
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