GO:0042975

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Name peroxisome proliferator activated receptor binding
Categary Function
Go Slim No
Go Link GO:0042975
Unique Molecular Interactions 85
Total Molecular Interactions 121
Total Single Events 468
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for peroxisome proliferator activated receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for peroxisome proliferator activated receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT114929 Positive_regulation of Binding of Oprm1 and Crebbp 1 0.06 0.14 1.28
2 INT114925 Binding of Oprm1 and Crebbp 1 0.06 0.14 1.27
3 INT262165 Nr0b2 Negative_regulation of Nr5a2 1 0.02 0.5 0.92
4 INT141362 EP300 Negative_regulation of Transcription of IL2 1 0.17 0 0.56
5 INT167651 Binding of Oprd1 and Ep300 1 0.02 0.09 0.55
6 INT167652 Binding of Ep300 and Ngf 1 0.09 0.06 0.51
7 INT167655 Binding of Polr2f and Ep300 1 0.01 0.06 0.51
8 INT114676 Mdm2 Negative_regulation of p53-ps 1 0.10 0.26 0.48
9 INT319718 Binding of Crebbp and Creb1 1 0.10 1.68 0.48
10 INT195552 Binding of Rela and Ep300 1 0.03 0.2 0.45
11 INT195554 Binding of Nfkb1 and Ep300 1 0.08 0.2 0.45
12 INT321293 Binding of Nr1h4 and Nr0b2 1 0.18 0.31 0.43
13 INT262186 Nr0b2 Positive_regulation of Negative_regulation of Cyp7a1 1 0.12 0.28 0.4
14 INT319729 Binding of Rela and Crebbp 1 0.02 0.88 0.37
15 INT182837 Binding of Creb1 and Crebbp 1 0.12 0.57 0.32
16 INT321288 Fig4 Positive_regulation of Nr0b2 1 0.15 0.47 0.27
17 INT262167 Binding of Nr1i2 and Nr0b2 1 0.15 0.11 0.25
18 INT256656 Binding of EP300 and HHIP 1 0.22 0 0.24
19 INT262179 Nr1i2 Regulation of Gene_expression of Nr0b2 1 0.09 0.07 0.24
20 INT325529 Binding of Stat3 and Ep300 1 0.01 0.22 0.19
21 INT325531 Positive_regulation of Binding of Stat3 and Ep300 1 0.02 0.22 0.19
22 INT321290 Positive_regulation of Nr1h4 Positive_regulation of Nr0b2 1 0.20 0.2 0.18
23 INT119265 Binding of CREBBP and PPM1E 1 0.01 0.46 0.17
24 INT119267 Binding of EP300 and PPM1E 1 0.01 0.46 0.17
25 INT194811 Binding of Crebbp and Nfatc1 1 0.00 0.07 0.16
26 INT194826 Binding of CREB1 and Crebbp 1 0.02 0.07 0.16
27 INT156833 Binding of MED1 and TRPV6 1 0.32 0 0.15
28 INT156837 Binding of CYP24A1 and MED1 1 0.47 0 0.15
29 INT287878 Binding of CREB1 and CREBBP 2 0.01 0.16 0.12
30 INT319726 Crebbp Positive_regulation of Binding of Rela 1 0.02 0.37 0.12
31 INT319731 Ep300 Positive_regulation of Binding of Rela 1 0.01 0.37 0.12
32 INT319727 Binding of Crebbp and Ep300 1 0.02 0.36 0.11
33 INT319728 Positive_regulation of Binding of Crebbp and Ep300 1 0.03 0.36 0.11
34 INT262207 Binding of Nr1i2 and Ep300 1 0.14 1.08 0.11
35 INT321299 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Nr0b2 1 0.02 0.31 0.1
36 INT287880 Binding of CREB1 and EP300 1 0.01 0 0.08
37 INT283721 Binding of Lpin1 and Id2 1 0.38 0.18 0.08
38 INT223536 Binding of HAND1 and Hmga1 1 0.26 0.57 0.07
39 INT223531 Binding of Hmga1 and Tcf3 1 0.26 0.57 0.07
40 INT119268 CDKN1A Regulation of CREBBP 1 0.21 0.44 0.07
41 INT119266 CDKN1A Regulation of EP300 1 0.47 0.44 0.07
42 INT225490 Med1 Positive_regulation of Ppara 1 0.12 0.26 0.06
43 INT321295 Negative_regulation of Fig4 Positive_regulation of Nr0b2 1 0.09 0.13 0.06
44 INT321284 Regulation of Fig4 Positive_regulation of Nr0b2 1 0.06 0.13 0.06
45 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06
46 INT229329 NR0B2 Negative_regulation of Nr1h2 1 0.03 0.58 0.05
47 INT229293 Positive_regulation of FXR1 Positive_regulation of Gene_expression of NR0B2 1 0.02 0.59 0.04
48 INT261393 Binding of Nsdhl and Med1 1 0.02 1 0.04
49 INT225569 Binding of Ncoa6 and Ep300 1 0.18 0.63 0.04
50 INT248700 Binding of Nr0b2 and Rxrb 1 0.01 0.29 0.03
51 INT321287 Positive_regulation of Fig4 Positive_regulation of Nr0b2 1 0.10 0.07 0.03
52 INT248699 Mapk8 Positive_regulation of Nr0b2 1 0.01 0.3 0.03
53 INT248701 Binding of Nr1i2 and Nr0b2 1 0.02 0.28 0.03
54 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0
55 INT225585 Regulation of Binding of Med1 and Tpr 1 0.00 0.07 0
56 INT225562 Binding of Srcs4 and Ep300 1 0.02 0 0
57 INT283715 Lpin1 Regulation of 4930579C15Rik 1 0.35 0.74 0
58 INT243106 Binding of Crebbp and Src 1 0.05 0.52 0
59 INT177262 Binding of MED1 and SV2A 1 0.23 0 0
60 INT287875 EP300 Negative_regulation of HDAC9 1 0.04 0.51 0
61 INT287882 Binding of CREBBP and HNF4A 1 0.01 0.85 0
62 INT172604 Binding of EP300 and TP53 1 0.00 0 0
63 INT243107 Binding of Src and Ep300 1 0.06 0.17 0
64 INT352617 Mdm2 Positive_regulation of Positive_regulation of Trp53 1 0.20 2.56 0
65 INT172606 EP300 Positive_regulation of CREBBP 1 0.00 0.07 0
66 INT235165 Atxn3 Regulation of Transcription of Crebbp 1 0.02 0.3 0
67 INT211570 Kit Regulation of Gene_expression of Lpin1 1 0.27 0.12 0
68 INT225619 Binding of TARBP2 and Ep300 1 0.02 0 0
69 INT225481 Binding of Med1 and Acp5 1 0.16 0 0
70 INT177286 Binding of CXADR and MED1 1 0.27 0 0
71 INT223523 Positive_regulation of Hmga1 Positive_regulation of Erv4 1 0.21 0.95 0
72 INT211577 Vldlr Regulation of Gene_expression of Lpin1 1 0.27 0.12 0
73 INT172605 Positive_regulation of Binding of EP300 and TP53 1 0.00 0 0
74 INT332963 Atp6v1e1 Negative_regulation of Binding of Crebbp 1 0.08 0 0
75 INT352614 Negative_regulation of Binding of Mdm2 and Trp53 1 0.19 1.16 0
76 INT225541 Binding of Med1 and Tpr 1 0.00 0.07 0
77 INT243111 Binding of Crebbp and Ep300 1 0.16 0.17 0
78 INT225543 Binding of D0Nrs1 and Ep300 1 0.01 0 0
79 INT225563 Binding of Tpr and Ep300 1 0.00 0 0
80 INT177280 Binding of MED1 and FAUP1 1 0.01 0 0
81 INT225622 Binding of STL and Ep300 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for peroxisome proliferator activated receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in peroxisome proliferator activated receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
2 INT152668 Negative_regulation of EP300 13 0.38 7.78 9.03
3 INT114675 Positive_regulation of Gene_expression of Mdm2 1 0.70 1.98 7.9
4 INT2213 Regulation of EP300 10 0.54 4.72 4.5
5 INT41878 Positive_regulation of EP300 13 0.61 5.24 3.95
6 INT171511 Gene_expression of EP300 14 0.53 4.17 2.29
7 INT26123 Regulation of Ep300 6 0.23 1.22 2.03
8 INT171514 Binding of EP300 13 0.32 4.32 2.01
9 INT26124 Negative_regulation of Ep300 5 0.37 1.25 1.94
10 INT248677 Positive_regulation of Nr0b2 3 0.42 4.49 1.91
11 INT172622 Localization of EP300 8 0.65 2.56 1.72
12 INT114671 Positive_regulation of Mdm2 1 0.61 0.5 1.38
13 INT319724 Binding of Crebbp 1 0.16 4.19 1.34
14 INT70821 Positive_regulation of Ep300 4 0.25 1.47 1.2
15 INT168167 Gene_expression of Hmga1 3 0.60 3.48 1.09
16 INT114673 Regulation of Gene_expression of Mdm2 1 0.62 0.23 1.02
17 INT167650 Binding of Ep300 1 0.09 0.14 1
18 INT211548 Gene_expression of Lpin1 9 0.76 12.83 0.96
19 INT117880 Negative_regulation of Crebbp 3 0.38 0.69 0.94
20 INT114922 Phosphorylation of Crebbp 2 0.21 0.92 0.94
21 INT262043 Gene_expression of Nr0b2 4 0.23 0.99 0.81
22 INT114956 Gene_expression of CREBBP 5 0.31 1.56 0.75
23 INT74097 Gene_expression of Ep300 6 0.52 1.89 0.73
24 INT114955 Positive_regulation of Gene_expression of CREBBP 2 0.23 0.24 0.61
25 INT182835 Phosphorylation of Crebbp 2 0.26 0.78 0.54
26 INT117879 Regulation of Crebbp 1 0.24 0 0.54
27 INT182836 Positive_regulation of Crebbp 2 0.21 0.76 0.53
28 INT321339 Binding of Nr0b2 1 0.22 0.72 0.53
29 INT321321 Negative_regulation of Positive_regulation of Nr0b2 1 0.26 0.45 0.49
30 INT262076 Positive_regulation of Gene_expression of Nr0b2 1 0.20 0.26 0.46
31 INT321303 Positive_regulation of Positive_regulation of Nr0b2 1 0.42 1.22 0.45
32 INT262049 Binding of Nr0b2 1 0.14 0.25 0.45
33 INT203478 Gene_expression of Crebbp 3 0.46 2.15 0.44
34 INT319725 Positive_regulation of Binding of Crebbp 1 0.17 1.12 0.4
35 INT145045 Gene_expression of Med1 29 0.65 5.37 0.39
36 INT233917 Gene_expression of MED1 2 0.20 0.17 0.38
37 INT187587 Binding of Ep300 11 0.35 2.37 0.34
38 INT321343 Transcription of Nr0b2 1 0.43 0.69 0.32
39 INT172957 Negative_regulation of Mdm2 4 0.14 4.28 0.3
40 INT321346 Positive_regulation of Localization of Nr0b2 1 0.30 0.25 0.3
41 INT321305 Localization of Nr0b2 1 0.45 0.25 0.29
42 INT106734 Phosphorylation of MED1 4 0.74 1.65 0.28
43 INT321324 Regulation of Nr0b2 1 0.27 0.63 0.28
44 INT319719 Negative_regulation of Binding of Crebbp 1 0.14 0.51 0.26
45 INT325492 Regulation of Ep300 1 0.04 0.29 0.24
46 INT221770 Positive_regulation of Phosphorylation of Crebbp 1 0.14 0.21 0.23
47 INT283693 Transcription of Lpin1 1 0.67 1.31 0.22
48 INT36479 Binding of NR0B2 2 0.36 3.5 0.21
49 INT212787 Negative_regulation of Binding of EP300 1 0.13 0.53 0.2
50 INT256666 Regulation of Gene_expression of EP300 1 0.14 0.07 0.2
51 INT256661 Regulation of Positive_regulation of EP300 1 0.23 0.07 0.2
52 INT172958 Positive_regulation of Mdm2 4 0.56 2.43 0.19
53 INT325490 Positive_regulation of Ep300 1 0.03 0.22 0.19
54 INT248684 Gene_expression of Nr0b2 4 0.41 1.26 0.17
55 INT321353 Negative_regulation of Transcription of Nr0b2 1 0.26 0.39 0.17
56 INT229301 Gene_expression of NR0B2 3 0.18 3.49 0.16
57 INT106730 Regulation of Phosphorylation of MED1 2 0.24 0.7 0.16
58 INT266010 Localization of Mdm2 2 0.75 2.64 0.15
59 INT204054 Negative_regulation of Negative_regulation of Mdm2 2 0.14 2.23 0.15
60 INT286764 Regulation of Localization of Mdm2 1 0.14 1.38 0.15
61 INT286748 Regulation of Mdm2 1 0.14 1.37 0.15
62 INT298653 Positive_regulation of Binding of EP300 1 0.11 0.8 0.15
63 INT152666 Negative_regulation of CREBBP 2 0.06 0.52 0.14
64 INT175517 Gene_expression of Mdm2 18 0.78 16.28 0.13
65 INT223502 Binding of Hmga1 1 0.27 0.96 0.13
66 INT223509 Positive_regulation of Gene_expression of Hmga1 1 0.38 0.96 0.13
67 INT211536 Binding of Lpin1 2 0.46 1.06 0.12
68 INT106731 Negative_regulation of Phosphorylation of MED1 1 0.02 0.96 0.12
69 INT319722 Positive_regulation of Crebbp 1 0.17 0.62 0.12
70 INT36480 Localization of NR0B2 1 0.73 0.78 0.12
71 INT319723 Protein_catabolism of Crebbp 1 0.30 0.56 0.12
72 INT321333 Regulation of Positive_regulation of Nr0b2 1 0.24 0.25 0.12
73 INT319721 Gene_expression of Crebbp 2 0.23 0.76 0.11
74 INT248679 Positive_regulation of Gene_expression of Nr0b2 3 0.30 0.82 0.1
75 INT229318 Positive_regulation of Gene_expression of NR0B2 1 0.12 1.17 0.09
76 INT171528 Binding of CREBBP 3 0.07 0.47 0.08
77 INT156864 Positive_regulation of Phosphorylation of MED1 1 0.45 0 0.07
78 INT283679 Positive_regulation of Lpin1 1 0.48 0.57 0.07
79 INT229311 Negative_regulation of NR0B2 1 0.14 0.58 0.05
80 INT283677 Localization of Lpin1 1 0.32 0.37 0.05
81 INT292252 Phosphorylation of EP300 1 0.20 0.55 0.05
82 INT319060 Localization of Crebbp 2 0.73 0 0.04
83 INT211538 Negative_regulation of Lpin1 1 0.57 1.28 0.04
84 INT321347 Negative_regulation of Gene_expression of Nr0b2 1 0.26 0.16 0.04
85 INT176240 Phosphorylation of Mdm2 2 0.22 1.28 0.03
86 INT203460 Negative_regulation of Gene_expression of Crebbp 2 0.25 0.73 0.03
87 INT243077 Regulation of Crebbp 1 0.27 0.13 0.03
88 INT176252 Positive_regulation of Phosphorylation of Mdm2 1 0.14 0.42 0.03
89 INT203462 Negative_regulation of Crebbp 1 0.02 0.62 0.03
90 INT243085 Positive_regulation of Gene_expression of Crebbp 1 0.30 0.14 0.03
91 INT187585 Binding of Crebbp 6 0.36 0.11 0
92 INT266011 Positive_regulation of Gene_expression of Mdm2 3 0.47 4.61 0
93 INT307189 Localization of Med1 3 0.53 0.32 0
94 INT235154 Transcription of Ep300 2 0.24 1.38 0
95 INT225400 Positive_regulation of Gene_expression of Med1 2 0.35 0.82 0
96 INT172620 Localization of CREBBP 2 0.09 0.06 0
97 INT225358 Negative_regulation of Gene_expression of Med1 2 0.30 1.16 0
98 INT337420 Negative_regulation of Localization of Crebbp 1 0.41 0 0
99 INT177336 Positive_regulation of Binding of MED1 1 0.24 0 0
100 INT340511 Localization of Crebbp 1 0.26 0 0
101 INT222914 Negative_regulation of Gene_expression of EP300 1 0.02 0.05 0
102 INT307197 Negative_regulation of Med1 1 0.30 0.7 0
103 INT307188 Transcription of Med1 1 0.48 0.7 0
104 INT337421 Negative_regulation of Binding of Crebbp 1 0.41 0 0
105 INT276802 Negative_regulation of Gene_expression of CREBBP 1 0.03 0 0
106 INT340512 Positive_regulation of Gene_expression of Crebbp 1 0.17 0 0
107 INT225389 Regulation of Binding of Med1 1 0.17 0.07 0
108 INT177320 Binding of MED1 1 0.25 0 0
109 INT225457 Binding of Med1 1 0.35 0.28 0
110 INT211543 Regulation of Lpin1 1 0.60 0.28 0
111 INT235158 Transcription of Crebbp 1 0.05 0.29 0
112 INT223519 Positive_regulation of Hmga1 1 0.35 0.87 0
113 INT341851 Positive_regulation of MED1 1 0.01 0.5 0
114 INT334482 Regulation of Gene_expression of Med1 1 0.17 0.1 0
115 INT332952 Positive_regulation of Binding of Crebbp 1 0.35 0 0
116 INT248674 Regulation of Gene_expression of Nr0b2 1 0.09 0.23 0
117 INT211562 Positive_regulation of Gene_expression of Lpin1 1 0.49 0.27 0
118 INT211545 Negative_regulation of Gene_expression of Lpin1 1 0.42 0.38 0
119 INT334481 Negative_regulation of Localization of Med1 1 0.16 0.09 0
120 INT266009 Negative_regulation of Gene_expression of Mdm2 1 0.43 1.03 0
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