GO:0042977

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Name activation of JAK2 kinase activity
Categary Process
Go Slim No
Go Link GO:0042977
Unique Molecular Interactions 82
Total Molecular Interactions 97
Total Single Events 608
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of JAK2 kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for activation of JAK2 kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
2 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
3 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
4 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
5 INT45279 Binding of CSF2 and GHR 1 0.05 0.07 0.93
6 INT73775 Binding of GH1 and GHR 4 0.35 0.68 0.8
7 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
8 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
9 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
10 INT73776 Regulation of Binding of GH1 and GHR 2 0.26 0.16 0.75
11 INT263977 PROC Negative_regulation of JAK2 1 0.00 0.93 0.47
12 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
13 INT134045 Jak2 Regulation of Stat3 1 0.26 0.13 0.47
14 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
15 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
16 INT134050 Positive_regulation of Jak2 Regulation of Stat3 1 0.44 0.13 0.47
17 INT151890 Binding of PRLR and Adarb1 1 0.00 0 0.45
18 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
19 INT328828 Binding of Jak2 and Jak1 1 0.24 0 0.38
20 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
21 INT328820 Binding of Il6 and Jak2 1 0.09 0 0.38
22 INT303994 Il6 Positive_regulation of JAK2 1 0.03 0.41 0.37
23 INT231535 Binding of JAK2 and SOAT1 1 0.01 0.3 0.35
24 INT184084 Jak2 Positive_regulation of Stat1 1 0.33 0.3 0.33
25 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
26 INT62616 Regulation of Binding of PRLR and ST14 1 0.00 0 0.31
27 INT62615 Binding of PRLR and ST14 1 0.00 0 0.31
28 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
29 INT25907 Binding of PRLR and Cish 1 0.00 0 0.23
30 INT151884 Binding of PRLR and YY1 1 0.01 0 0.23
31 INT240536 Il12a Positive_regulation of Jak2 1 0.10 0.74 0.21
32 INT68510 Binding of ATM and PRLR 1 0.01 0 0.19
33 INT188358 Binding of Csf2 and Positive_regulation of Jak2 1 0.34 0.19 0.11
34 INT169340 Binding of UGT8 and Jak2 1 0.36 0.15 0.11
35 INT273374 Binding of JAK2 and STAT3 1 0.24 0 0.07
36 INT273368 Negative_regulation of Binding of JAK2 and STAT3 1 0.28 0 0.07
37 INT242480 Ciapin1 Positive_regulation of Gene_expression of Jak2 1 0.27 1.05 0.07
38 INT273371 JAK2 Regulation of Protein_catabolism of SOCS1 1 0.01 0 0.06
39 INT200807 Jak2 Positive_regulation of Mvd 1 0.18 3.46 0.06
40 INT325769 Binding of EPOR and Positive_regulation of Phosphorylation of JAK2 1 0.66 0 0.06
41 INT273365 JAK2 Regulation of SOCS1 1 0.01 0 0.06
42 INT238117 Positive_regulation of STAT3 Positive_regulation of Gene_expression of JAK2 1 0.11 0 0.05
43 INT238116 STAT3 Positive_regulation of Gene_expression of JAK2 1 0.16 0 0.05
44 INT268798 Binding of Gh and Ghr 1 0.26 1.18 0.04
45 INT200821 Binding of Jak2 and Mvd 1 0.14 0.68 0.04
46 INT200813 Jak2 Positive_regulation of Akt1 1 0.26 1.46 0.03
47 INT253578 Csnk2a2 Negative_regulation of Jak2 1 0.09 0 0.03
48 INT253573 Binding of Jak2 and Pik3r1 1 0.06 0 0.03
49 INT200816 Jak2 Positive_regulation of Binding of Mvd 1 0.19 1.51 0.03
50 INT200810 Jak2 Positive_regulation of Src 1 0.29 1.46 0.03
51 INT249597 Jak2 Positive_regulation of Phosphorylation of Stat1 1 0.20 0.13 0.03
52 INT253575 Binding of Jak2 and Pik3r2 1 0.00 0 0.03
53 INT200815 Binding of Epo and Jak2 1 0.36 0.98 0.03
54 INT265881 GHRH Positive_regulation of GHR 1 0.05 0.05 0.03
55 INT200822 Akt1 Regulation of Jak2 1 0.25 1.48 0.03
56 INT340502 Agtr1a Negative_regulation of Phosphorylation of Jak2 1 0.12 2.32 0
57 INT253366 Il6 Positive_regulation of Phosphorylation of Jak2 1 0.31 0.2 0
58 INT173769 Dlat Regulation of Ghr 1 0.04 0 0
59 INT200819 Epo Positive_regulation of Gene_expression of Jak2 1 0.49 0.91 0
60 INT300081 Binding of JAK2 and TYK2 1 0.09 1.13 0
61 INT216465 Gh Positive_regulation of Ghr 1 0.26 0.23 0
62 INT247003 Binding of Ghr and Gh1 1 0.00 0 0
63 INT350503 Binding of HSP90AA1 and JAK2 1 0.06 1.39 0
64 INT312304 Binding of JAK2 and VEGFA 1 0.30 0.82 0
65 INT241535 Abl1 Regulation of Positive_regulation of Jak2 1 0.10 0.53 0
66 INT198026 JAK2 Positive_regulation of HCC 1 0.19 1.35 0
67 INT350505 Negative_regulation of Binding of HSP90AA1 and JAK2 1 0.07 1.5 0
68 INT350504 ABL1 Negative_regulation of JAK2 1 0.20 2.18 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of JAK2 kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in activation of JAK2 kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT12367 Binding of PRLR 17 0.03 2.05 9.69
2 INT9895 Binding of GHR 18 0.36 4.8 5.65
3 INT13313 Regulation of PRLR 7 0.07 1.65 4.77
4 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
5 INT95512 Transcription of Ghr 24 0.69 3.1 4.12
6 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
7 INT18825 Gene_expression of PRLR 8 0.40 2 3.47
8 INT20082 Positive_regulation of PRLR 6 0.29 4.27 3.03
9 INT59905 Gene_expression of Ghr 29 0.63 9.25 2.97
10 INT25646 Negative_regulation of PRLR 5 0.08 0.08 2.62
11 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
12 INT113339 Binding of JAK2 6 0.40 5.31 2.4
13 INT22019 Regulation of GHR 9 0.62 2.56 2.39
14 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
15 INT34266 Negative_regulation of Binding of PRLR 3 0.01 0 2.35
16 INT16286 Positive_regulation of GHR 8 0.60 4.04 2.31
17 INT67352 Transcription of Ghr 8 0.61 1.55 2.3
18 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16
19 INT95510 Regulation of Ghr 1 0.45 0.21 2.07
20 INT4643 Negative_regulation of GHR 10 0.45 3.01 2
21 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
22 INT75316 Gene_expression of Ghr 6 0.78 1.24 1.68
23 INT113340 Phosphorylation of JAK2 17 0.78 5.69 1.6
24 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
25 INT28300 Gene_expression of GHR 10 0.78 4.29 1.5
26 INT67348 Negative_regulation of Ghr 8 0.40 2.84 1.43
27 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
28 INT75315 Regulation of Ghr 4 0.22 1.5 1.34
29 INT95511 Negative_regulation of Transcription of Ghr 1 0.43 0 1.15
30 INT20080 Localization of PRLR 2 0.03 0.42 1.12
31 INT61512 Regulation of Binding of GHR 2 0.05 0.89 1.1
32 INT205912 Negative_regulation of Gene_expression of Jak2 8 0.42 5.1 1.04
33 INT95514 Negative_regulation of Ghr 3 0.36 1.3 0.99
34 INT198049 Positive_regulation of JAK2 16 0.58 5.35 0.96
35 INT169336 Binding of Jak2 2 0.42 1.31 0.93
36 INT134040 Regulation of Jak2 3 0.41 1.07 0.92
37 INT95507 Negative_regulation of Gene_expression of Ghr 3 0.33 0.49 0.91
38 INT184027 Phosphorylation of Jak2 6 0.82 2.58 0.87
39 INT134037 Positive_regulation of Phosphorylation of Jak2 1 0.46 0.25 0.86
40 INT216456 Positive_regulation of Ghr 6 0.41 4.96 0.85
41 INT238201 Gene_expression of JAK2 9 0.70 7.09 0.81
42 INT237408 Positive_regulation of Positive_regulation of Jak2 1 0.28 1.56 0.79
43 INT245584 Positive_regulation of Gene_expression of Ghr 5 0.41 3.46 0.75
44 INT113342 Positive_regulation of Phosphorylation of JAK2 2 0.66 2.58 0.72
45 INT73783 Regulation of Gene_expression of GHR 1 0.45 0 0.7
46 INT95506 Negative_regulation of Transcription of Ghr 1 0.15 0 0.6
47 INT95508 Negative_regulation of Gene_expression of Ghr 1 0.59 0 0.56
48 INT95375 Regulation of Transcription of PRLR 1 0.00 0 0.49
49 INT95377 Regulation of Gene_expression of PRLR 1 0.00 0 0.49
50 INT95376 Transcription of PRLR 1 0.00 0 0.49
51 INT184062 Binding of Jak2 5 0.37 3.13 0.47
52 INT205890 Transcription of Jak2 1 0.41 0.22 0.43
53 INT145854 Gene_expression of Jak2 4 0.67 3.08 0.41
54 INT173752 Positive_regulation of Ghr 3 0.57 2.21 0.41
55 INT107462 Localization of Jak2 2 0.60 0.78 0.4
56 INT82331 Positive_regulation of Positive_regulation of GHR 1 0.00 0.06 0.4
57 INT229697 Negative_regulation of Phosphorylation of Jak2 1 0.15 0.54 0.39
58 INT200786 Positive_regulation of Gene_expression of Jak2 9 0.69 6.03 0.35
59 INT28299 Negative_regulation of Gene_expression of GHR 1 0.03 0.1 0.35
60 INT205910 Negative_regulation of Positive_regulation of Jak2 1 0.33 0.26 0.35
61 INT67350 Binding of Ghr 9 0.43 1.83 0.28
62 INT20081 Positive_regulation of Localization of PRLR 1 0.03 0.07 0.27
63 INT303972 Positive_regulation of Gene_expression of JAK2 2 0.63 1.3 0.24
64 INT67349 Localization of Ghr 6 0.66 2.53 0.23
65 INT67351 Positive_regulation of Localization of Ghr 2 0.44 0.78 0.23
66 INT62617 Positive_regulation of Positive_regulation of PRLR 1 0.01 0 0.19
67 INT328811 Negative_regulation of Localization of Jak2 1 0.34 0.13 0.17
68 INT200802 Regulation of Jak2 5 0.61 2.86 0.16
69 INT75314 Regulation of Gene_expression of Ghr 3 0.26 0.42 0.15
70 INT220367 Regulation of Positive_regulation of Ghr 1 0.44 0.45 0.14
71 INT22020 Regulation of Positive_regulation of GHR 1 0.39 1.03 0.14
72 INT268793 Protein_catabolism of Ghr 1 0.69 0.54 0.12
73 INT278143 Positive_regulation of Negative_regulation of Jak2 1 0.16 0.54 0.11
74 INT245586 Phosphorylation of Ghr 1 0.44 0.35 0.1
75 INT312354 Regulation of Gene_expression of JAK2 1 0.25 1.17 0.1
76 INT200792 Regulation of Gene_expression of Jak2 5 0.61 5.69 0.09
77 INT173756 Positive_regulation of Transcription of Ghr 3 0.36 0.83 0.09
78 INT268791 Positive_regulation of Protein_catabolism of Ghr 1 0.39 0.29 0.09
79 INT184018 Negative_regulation of Protein_catabolism of Jak2 1 0.36 1.76 0.08
80 INT184023 Protein_catabolism of Jak2 1 0.61 1.75 0.08
81 INT200180 Negative_regulation of Localization of Ghr 3 0.35 0.89 0.07
82 INT310747 Regulation of JAK2 2 0.33 1.58 0.05
83 INT238202 Negative_regulation of Localization of JAK2 1 0.09 0 0.05
84 INT238200 Localization of JAK2 1 0.16 0 0.05
85 INT184168 Localization of GHR 1 0.08 0.34 0.05
86 INT356345 Negative_regulation of Negative_regulation of Ghr 1 0.35 0.24 0.04
87 INT238199 Positive_regulation of Positive_regulation of JAK2 1 0.10 0 0.03
88 INT319565 Positive_regulation of Gene_expression of GHR 1 0.25 0.4 0
89 INT173755 Binding of Ghr 1 0.14 0 0
90 INT181205 Negative_regulation of Binding of GHR 1 0.07 0.2 0
91 INT238196 Negative_regulation of Binding of JAK2 1 0.09 0 0
92 INT75317 Regulation of Gene_expression of Ghr 1 0.03 0.26 0
93 INT202420 Transcription of Jak2 1 0.56 0.91 0
94 INT350506 Protein_catabolism of JAK2 1 0.48 1.55 0
95 INT320539 Negative_regulation of Phosphorylation of JAK2 1 0.26 0.46 0
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