GO:0042981

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Name regulation of apoptotic process
Categary Process
Go Slim No
Go Link GO:0042981
Unique Molecular Interactions 3460
Total Molecular Interactions 4640
Total Single Events 39198
Pain Genes Associated 215

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of apoptotic process. They are ordered first by their pain relevance and then by number of times they were reported for regulation of apoptotic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT79759 Ngf Regulation of Il6 1 0.60 4.62 5.62
3 INT164362 Binding of NLRP1 and VTA1 1 0.15 2.37 4.67
4 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
5 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
6 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
7 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
8 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
9 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
10 INT161164 Prkcg Regulation of Phosphorylation of Creb1 3 0.41 0.62 3.11
11 INT309150 Edc4 Positive_regulation of Creb1 1 0.03 3.46 3.09
12 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
13 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2 0.06 2.01 2.85
14 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
15 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
16 INT154188 Il6 Positive_regulation of Gene_expression of Atf3 1 0.76 3.07 2.71
17 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
18 INT294909 Pax3 Positive_regulation of Gene_expression of Il6 1 0.09 5.43 2.51
19 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
20 INT156622 Umod Regulation of Phosphorylation of Creb1 1 0.05 0.33 2.27
21 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
22 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
23 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
24 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
25 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
26 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
27 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
28 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
29 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 0.00 2.11 2.08
30 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
31 INT158964 FosB Negative_regulation of Creb1 1 0.21 0 2.07
32 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
33 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
34 INT70043 IL6 Regulation of IL10 3 0.18 3.59 2.01
35 INT124133 Camk2a Regulation of Phosphorylation of Creb1 1 0.46 0 2
36 INT164784 Il6 Positive_regulation of Gene_expression of Cx3cr1 1 0.47 2.37 1.98
37 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
38 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
39 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 0.28 1.93 1.93
40 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91
41 INT186435 Prkcg Regulation of Creb1 1 0.44 0.45 1.9
42 INT186432 Prkaca Regulation of Creb1 1 0.14 0.45 1.9
43 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
44 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
45 INT155460 Tnfrsf1a Positive_regulation of Positive_regulation of Nfkb1 1 0.42 2.39 1.82
46 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
47 INT165183 Ifnb1 Positive_regulation of P2rx4 1 0.04 1.73 1.73
48 INT139190 Binding of Fadd and Fas 4 0.38 2.65 1.71
49 INT186433 Trib3 Regulation of Phosphorylation of Creb1 1 0.03 0.32 1.71
50 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
51 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
52 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 0.52 6.58 1.68
53 INT155459 Tnfrsf1a Positive_regulation of Nfkb1 1 0.42 2.45 1.63
54 INT131574 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Creb1 1 0.41 0.33 1.58
55 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
56 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
57 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56
58 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55
59 INT135276 Gt(pU21)50Imeg Negative_regulation of Gene_expression of Il6 1 0.02 0.52 1.52
60 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
61 INT121747 Prkcg Negative_regulation of Positive_regulation of Creb1 1 0.16 0.2 1.5
62 INT126718 Binding of Il6 and Il6r 3 0.09 2.33 1.49
63 INT121741 Prkaca Negative_regulation of Positive_regulation of Creb1 1 0.10 0.2 1.49
64 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
65 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
66 INT150885 Il6 Regulation of Il10 1 0.22 1.74 1.47
67 INT73650 Binding of Pim3 and Creb1 1 0.03 2.48 1.47
68 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
69 INT155371 VIP Positive_regulation of Localization of IL6 1 0.64 3.37 1.44
70 INT236365 Binding of CD40LG and IL6 3 0.20 4.16 1.42
71 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4
72 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
73 INT168724 Creb1 Negative_regulation of Gene_expression of Calca 1 0.46 1.09 1.38
74 INT168721 Positive_regulation of Creb1 Positive_regulation of Calca 1 0.53 1.07 1.37
75 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36
76 INT106850 P2ry2 Positive_regulation of Phosphorylation of Creb1 2 0.49 0.73 1.36
77 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 0.16 4.47 1.35
78 INT168722 Creb1 Positive_regulation of Calca 1 0.73 1.05 1.35
79 INT158079 Binding of Esr1 and Gper 1 0.31 0.97 1.35
80 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
81 INT222182 Binding of ESR1 and HLA-DRB2 1 0.00 3.1 1.35
82 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
83 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32
84 INT71395 Ugt2a2 Regulation of Bcl2a1a 1 0.00 0.1 1.32
85 INT182096 Positive_regulation of Binding of Il6 and Il1 2 0.09 4.26 1.31
86 INT150890 Binding of Esr1 and Esr2 2 0.52 2.06 1.31
87 INT131886 Creb1 Positive_regulation of Gene_expression of Prkcg 1 0.03 0 1.31
88 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
89 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
90 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
91 INT162482 Binding of Agt and Vta1 1 0.23 0 1.27
92 INT124767 Creb1 Regulation of Oprm1 1 0.45 0 1.26
93 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
94 INT155663 Positive_regulation of P2rx4 Positive_regulation of Localization of Bdnf 1 0.42 0.84 1.25
95 INT121190 KCNMA1 Positive_regulation of Gene_expression of IL6 1 0.03 0.54 1.24
96 INT136250 Phosphorylation of Tff3 Regulation of Creb1 1 0.02 0.18 1.24
97 INT283426 Binding of Lcn2 and Nt5e 1 0.08 5.8 1.24
98 INT136256 Creb1 Regulation of SGCG 1 0.26 0.18 1.23
99 INT136258 Creb1 Regulation of GRIA1 1 0.26 0.18 1.23
100 INT121189 KCNMA1 Positive_regulation of IL6 1 0.04 0.54 1.23
101 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22
102 INT256298 Binding of Creb1 and Ephb1 1 0.16 1.27 1.22
103 INT70033 IL6 Regulation of PRF1 1 0.03 1.42 1.21
104 INT164365 Positive_regulation of Binding of NLRP1 and VTA1 1 0.14 0.6 1.21
105 INT70047 IL6 Regulation of Negative_regulation of PRF1 1 0.03 1.42 1.21
106 INT70029 IL6 Regulation of Negative_regulation of IL10 1 0.05 1.42 1.21
107 INT98832 Th Regulation of Dbh 1 0.32 0.53 1.2
108 INT256297 Binding of Creb1 and Insrr 1 0.00 1.22 1.19
109 INT256295 Binding of Creb1 and Grin2b 1 0.11 1.21 1.19
110 INT124435 Gene_expression of Chrna9 Positive_regulation of Phosphorylation of Creb1 1 0.11 0.6 1.17
111 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16
112 INT189017 Binding of Pax3 and Lmna 1 0.14 0.42 1.16
113 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
114 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15
115 INT94490 Il6 Positive_regulation of Gene_expression of Avp 1 0.33 1.97 1.15
116 INT94508 Il6 Positive_regulation of Gene_expression of AVP 1 0.42 1.96 1.14
117 INT294911 Pax3 Positive_regulation of Il6 1 0.06 1.78 1.14
118 INT76199 CASP1 Positive_regulation of CEL 1 0.06 0.32 1.14
119 INT68157 Alox5 Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.13
120 INT68154 Mthfs Positive_regulation of Pdpk1 1 0.01 0.63 1.12
121 INT94496 Il6 Positive_regulation of Gene_expression of Crh 1 0.29 1.94 1.12
122 INT68158 Pla2g1b Positive_regulation of Pdpk1 1 0.05 0.63 1.12
123 INT68159 Pla2g1b Positive_regulation of Positive_regulation of Pdpk1 1 0.05 0.64 1.12
124 INT68163 Mthfs Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.12
125 INT68165 Alox5 Positive_regulation of Pdpk1 1 0.01 0.63 1.12
126 INT294710 CRP Positive_regulation of Gene_expression of IL6 1 0.63 1.9 1.12
127 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11
128 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11
129 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
130 INT109374 Ppp1cc Negative_regulation of Ppp2r1a 1 0.24 0 1.11
131 INT99691 Pdpk1 Positive_regulation of Positive_regulation of VEGFA 1 0.01 0.72 1.11
132 INT108546 BCL2L10 Regulation of MAPKAPK5 1 0.03 1.22 1.1
133 INT223157 Abat Negative_regulation of Localization of Il6 1 0.05 1.13 1.1
134 INT2457 Agt Positive_regulation of Localization of Avp 5 0.59 0.2 1.09
135 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
136 INT31549 Binding of Dbh and Vip 1 0.32 0 1.08
137 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
138 INT156462 Creb1 Regulation of Ephb1 1 0.29 0 1.07
139 INT329959 Binding of TRAF1 and HEPACAM 1 0.03 2.25 1.06
140 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
141 INT119888 Binding of Creb1 and Usf1 1 0.18 0.15 1.05
142 INT120316 Ghrh Regulation of Il6 1 0.11 0.95 1.05
143 INT120310 Ghrh Regulation of Positive_regulation of Il6 1 0.18 0.95 1.05
144 INT74027 Creb1 Regulation of Jun 4 0.27 1.04 1.02
145 INT61617 PTGER2 Regulation of Gene_expression of IL6 3 0.11 1.13 1.02
146 INT87025 ZAK Positive_regulation of Gene_expression of IL6 2 0.11 1.59 1.02
147 INT98555 Oprm1 Positive_regulation of Casp8 1 0.51 0.36 1.02
148 INT218310 IL6 Positive_regulation of Localization of CRP 1 0.29 3.33 1.02
149 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
150 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
151 INT79602 Binding of PSMA5 and Oprd1 2 0.19 1.05 1.01
152 INT174910 Binding of LBP and IFIH1 1 0.04 1.01 1.01
153 INT278946 IL6 Regulation of Gene_expression of IL8 1 0.20 1.9 1
154 INT91813 Binding of FAS and FASLG 4 0.23 9.89 0.99
155 INT142202 FL Positive_regulation of Bcl2 1 0.05 0.39 0.99
156 INT86181 SFTPA1 Positive_regulation of IL6 1 0.07 0.32 0.99
157 INT244133 DDB1 Positive_regulation of Gene_expression of IL6 1 0.01 1.91 0.99
158 INT31548 Binding of Th and Dbh 1 0.35 0 0.98
159 INT317836 Binding of Fibp and Pycard 1 0.00 2.68 0.98
160 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
161 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
162 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
163 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
164 INT278292 Binding of CRP and ESR1 6 0.09 10.92 0.96
165 INT133617 Fas Positive_regulation of Fadd 1 0.48 0.07 0.96
166 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
167 INT289173 PYCARD Regulation of MFGE8 1 0.05 0 0.96
168 INT29366 Mnt Positive_regulation of Localization of Penk 1 0.01 0 0.96
169 INT272984 Il6 Positive_regulation of Gene_expression of Itgam 1 0.24 0.78 0.96
170 INT163390 Il6 Positive_regulation of Gene_expression of Crp 2 0.03 3.42 0.95
171 INT274899 Positive_regulation of P2rx4 Positive_regulation of Localization of Gtf3a 1 0.02 1.67 0.95
172 INT141373 Ier3 Positive_regulation of CREM 1 0.00 0 0.95
173 INT299988 IL6 Positive_regulation of Localization of IL8 1 0.05 0.81 0.94
174 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
175 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
176 INT73467 PTPLA Positive_regulation of Transcription of Myc 1 0.29 0.97 0.94
177 INT285418 IRF6 Positive_regulation of Localization of IL6 3 0.05 0.66 0.93
178 INT153685 Binding of Bcl2l11 and Gtpbp4 1 0.08 0.76 0.93
179 INT107335 Pdpk1 Positive_regulation of Regulation of Sigmar1 1 0.02 0 0.93
180 INT134785 Il2rb Regulation of Gene_expression of IL6 1 0.00 1.16 0.92
181 INT186431 Trib3 Regulation of Creb1 1 0.03 0.23 0.92
182 INT134784 Il2rb Regulation of IL6 1 0.00 1.16 0.92
183 INT138602 Negative_regulation of BCL2L2 Positive_regulation of F2 1 0.00 0.67 0.92
184 INT252879 Creb1 Positive_regulation of Gene_expression of Tacr1 1 0.03 0.24 0.91
185 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
186 INT12050 Agt Positive_regulation of Localization of Oxt 1 0.29 0 0.91
187 INT112765 Binding of Nfkb1 and Bcl2 1 0.00 1.37 0.91
188 INT138601 BCL2L2 Positive_regulation of F2 1 0.00 0.66 0.91
189 INT36999 Binding of HLA-DRB2 and TNFRSF25 1 0.05 3.46 0.91
190 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
191 INT78062 Il1a Positive_regulation of Localization of Il6 3 0.24 0.48 0.9
192 INT219037 Creb1 Positive_regulation of Transcription of Bdnf 2 0.43 1.07 0.9
193 INT64717 Pomc Positive_regulation of Il6 1 0.13 0.19 0.9
194 INT77253 Binding of gr and Creb1 1 0.03 0.4 0.9
195 INT309140 Dlat Positive_regulation of Creb1 1 0.06 1.1 0.9
196 INT108647 Binding of Grin2a and Camk1d 1 0.33 0.78 0.9
197 INT91270 Oprd1 Regulation of Gene_expression of Il6 1 0.00 0 0.89
198 INT142128 Nrgn Regulation of Creb1 1 0.38 0.25 0.89
199 INT159962 Rock2 Regulation of Localization of Il6 1 0.09 2.7 0.88
200 INT91273 Mtr Positive_regulation of Localization of Il6 1 0.17 0 0.88

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of apoptotic process. They are ordered first by their pain relevance and then by number of times they were reported in regulation of apoptotic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22
2 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57
3 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57
4 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97
5 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59
6 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38
7 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132
8 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28
9 INT11011 Positive_regulation of Phosphorylation of Creb1 190 0.70 49.25 112.01
10 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96
11 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3
12 INT12082 Localization of IL6 365 0.81 241.78 105.78
13 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26
14 INT19511 Localization of Il6 212 0.81 118.17 67.67
15 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34
16 INT11937 Localization of Il6 228 0.81 139.83 64.39
17 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
18 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6
19 INT10706 Regulation of Il6 150 0.62 93.23 62.34
20 INT102020 Gene_expression of Creb1 190 0.78 57.31 59.77
21 INT82055 Positive_regulation of Creb1 176 0.70 60.2 58.39
22 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87
23 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
24 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78
25 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15
26 INT1232 Positive_regulation of Pdpk1 78 0.42 24.33 50.17
27 INT9210 Regulation of IL6 166 0.62 125.61 49.95
28 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81
29 INT88617 Positive_regulation of Gene_expression of Creb1 90 0.69 51.69 44.29
30 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67
31 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24
32 INT18992 Negative_regulation of Pdpk1 53 0.42 19.02 40.95
33 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38
34 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38
35 INT385 Gene_expression of Agt 182 0.78 63.62 37.91
36 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
37 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53
38 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08
39 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
40 INT11013 Negative_regulation of Phosphorylation of Creb1 55 0.59 18.74 34.66
41 INT16714 Regulation of Creb1 64 0.62 22.23 33.56
42 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58
43 INT9655 Regulation of Il6 98 0.62 70.92 31.95
44 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
45 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07
46 INT1158 Regulation of Agt 106 0.61 29.4 30.29
47 INT57379 Positive_regulation of Phosphorylation of Creb1 79 0.69 28.24 30.25
48 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52
49 INT86437 Binding of IL6 154 0.48 121.22 29.3
50 INT11010 Regulation of Phosphorylation of Creb1 52 0.62 7.26 29.04
51 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
52 INT1166 Negative_regulation of Dbh 56 0.59 12.54 28.26
53 INT37296 Binding of Esr1 117 0.43 62.51 27.33
54 INT20462 Binding of ESR1 210 0.44 102.7 26.34
55 INT86062 Positive_regulation of Tnfrsf1a 51 0.69 40.69 26.2
56 INT86789 Gene_expression of P2rx4 46 0.77 30.66 25.68
57 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64
58 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48
59 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27
60 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03
61 INT102021 Positive_regulation of Gene_expression of Creb1 66 0.70 24.04 23.28
62 INT61160 Negative_regulation of Gene_expression of Creb1 37 0.59 17.95 23.17
63 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09
64 INT12114 Positive_regulation of Tnfrsf1a 46 0.69 36.26 22.54
65 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52
66 INT106175 Positive_regulation of Positive_regulation of Creb1 37 0.70 13.89 22.46
67 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
68 INT83797 Gene_expression of Bcl2l1 124 0.77 94.55 22.39
69 INT3382 Positive_regulation of Dbh 33 0.70 11.64 21.67
70 INT112427 Positive_regulation of P2rx4 27 0.68 26.29 21.31
71 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94
72 INT51474 Binding of Il6 55 0.48 44.99 20.52
73 INT61159 Regulation of Gene_expression of Creb1 46 0.62 24.07 20.52
74 INT48769 Regulation of Pdpk1 20 0.35 9.78 20.36
75 INT49985 Transcription of Il6 62 0.72 40.13 20.29
76 INT14436 Gene_expression of Dbh 42 0.72 9.9 19.85
77 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
78 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01
79 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98
80 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97
81 INT2960 Regulation of Dbh 32 0.47 10.32 18.94
82 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
83 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25
84 INT62577 Negative_regulation of Creb1 55 0.59 19.68 18.1
85 INT61158 Negative_regulation of Creb1 33 0.59 11.54 18.06
86 INT151747 Positive_regulation of PSMD2 26 0.68 17.48 17.89
87 INT61626 Transcription of IL6 73 0.72 42.04 17.86
88 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71
89 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52
90 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
91 INT17237 Regulation of Esr1 74 0.43 49.09 17.25
92 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
93 INT102023 Regulation of Creb1 51 0.62 16.29 16.71
94 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
95 INT164366 Localization of NLRP1 26 0.71 5.9 16.54
96 INT4073 Localization of Dbh 28 0.81 6.06 16.37
97 INT2066 Localization of Agt 56 0.80 9.95 16.25
98 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2
99 INT50932 Positive_regulation of Positive_regulation of Il6 36 0.69 24.9 16.12
100 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
101 INT92354 Localization of ESR1 77 0.75 33.04 15.51
102 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15
103 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99
104 INT49376 Negative_regulation of Localization of Il6 37 0.59 12.66 14.99
105 INT127046 Gene_expression of P2RX7 65 0.78 34.28 14.76
106 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36
107 INT26733 Gene_expression of Pdpk1 17 0.48 5.74 13.91
108 INT55256 Negative_regulation of Localization of Il6 38 0.58 16.12 13.67
109 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
110 INT3623 Negative_regulation of CTSB 49 0.55 27.39 13.52
111 INT107248 Negative_regulation of Gene_expression of Creb1 26 0.58 9.24 13.41
112 INT2038 Localization of Esr1 104 0.79 40.12 13.27
113 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18
114 INT16713 Binding of Creb1 53 0.48 20.24 13.06
115 INT54763 Binding of Il6 82 0.48 63.27 12.89
116 INT55255 Positive_regulation of Localization of Il6 48 0.69 24.88 12.76
117 INT4199 Binding of Agt 76 0.48 21.06 12.66
118 INT12084 Regulation of Localization of IL6 36 0.61 20.32 12.34
119 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18
120 INT21160 Gene_expression of Sell 28 0.64 19.37 12.18
121 INT145425 Positive_regulation of NLRP1 19 0.47 6.93 12.09
122 INT122053 Positive_regulation of P2rx4 16 0.69 13.02 11.98
123 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63
124 INT50933 Transcription of Il6 38 0.72 24.31 11.58
125 INT20603 Positive_regulation of TNFRSF10B 40 0.67 32.61 11.44
126 INT5630 Localization of Pdpk1 10 0.45 5.21 11.36
127 INT49396 Negative_regulation of Positive_regulation of Il6 29 0.59 16.39 11.31
128 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67
129 INT62576 Transcription of Creb1 34 0.69 16.97 10.6
130 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59
131 INT109280 Negative_regulation of Phosphorylation of Creb1 29 0.59 11.81 10.37
132 INT98329 Gene_expression of P2RX4 23 0.75 13.13 10.25
133 INT7411 Localization of FGFR3 40 0.78 4.77 10.24
134 INT99505 Gene_expression of Bcl2l1 42 0.77 33.12 10.15
135 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08
136 INT137980 Positive_regulation of P2RX7 30 0.67 22.49 10
137 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
138 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
139 INT112428 Positive_regulation of Gene_expression of P2rx4 12 0.68 12.67 9.57
140 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51
141 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4
142 INT168991 Negative_regulation of P2rx4 9 0.43 12.77 9.39
143 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37
144 INT71174 Gene_expression of CASP1 44 0.75 30.3 9.37
145 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28
146 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22
147 INT54588 Positive_regulation of CREB1 38 0.67 12.01 9.18
148 INT109279 Regulation of Phosphorylation of Creb1 14 0.62 4.06 8.96
149 INT3622 Regulation of CTSB 34 0.58 16.08 8.76
150 INT386 Positive_regulation of Gene_expression of Agt 37 0.70 15.92 8.73
151 INT87434 Gene_expression of Sell 38 0.77 21.95 8.51
152 INT80034 Positive_regulation of Gene_expression of FAS 32 0.67 30.34 8.51
153 INT77790 Positive_regulation of Gene_expression of Tnfrsf1a 16 0.67 15.88 8.5
154 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
155 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37
156 INT93673 Transcription of Creb1 19 0.66 9.27 8.26
157 INT136177 Gene_expression of P2rx4 8 0.75 6.74 8.05
158 INT5401 Gene_expression of DBH 17 0.78 1.92 8.01
159 INT15687 Regulation of ESR1 91 0.60 40.42 7.95
160 INT87271 Positive_regulation of Phosphorylation of CREB1 27 0.66 12.87 7.91
161 INT104013 Negative_regulation of Gene_expression of Pdpk1 4 0.31 2.36 7.89
162 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86
163 INT97516 Binding of PYCARD 46 0.36 7.06 7.85
164 INT47546 Binding of Dbh 11 0.44 5.69 7.84
165 INT73595 Positive_regulation of BAX 61 0.61 56.97 7.82
166 INT87139 Negative_regulation of Positive_regulation of Il6 18 0.59 10.65 7.76
167 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71
168 INT69033 Negative_regulation of Casp1 21 0.58 13.15 7.52
169 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
170 INT38503 Positive_regulation of Ripk2 11 0.67 2.9 7.47
171 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41
172 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36
173 INT102107 Negative_regulation of Gene_expression of Bax 30 0.57 29.48 7.33
174 INT116619 Positive_regulation of Positive_regulation of Creb1 25 0.69 8.32 7.3
175 INT86867 Regulation of CREB1 15 0.46 4.95 7.28
176 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
177 INT145299 Negative_regulation of Jak3 25 0.48 17.66 7.13
178 INT106330 Regulation of Positive_regulation of Creb1 11 0.56 5.57 7.06
179 INT76120 Gene_expression of Ptprc 102 0.59 30.42 7.02
180 INT111377 Positive_regulation of Ifih1 16 0.60 11.22 6.99
181 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94
182 INT102749 Positive_regulation of Positive_regulation of CASP3 32 0.67 26.07 6.93
183 INT71824 Phosphorylation of Pdpk1 14 0.38 4.9 6.86
184 INT1766 Negative_regulation of PYCARD 25 0.37 6.54 6.76
185 INT114642 Negative_regulation of Positive_regulation of Creb1 12 0.57 2.32 6.75
186 INT16344 Gene_expression of CASP4 11 0.74 4.64 6.75
187 INT110987 Transcription of ESR1 45 0.71 24.16 6.72
188 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71
189 INT112430 Negative_regulation of P2rx4 9 0.57 8.4 6.63
190 INT21161 Positive_regulation of Sell 11 0.58 8.64 6.57
191 INT13385 Gene_expression of Bad 60 0.76 41.86 6.52
192 INT108585 Positive_regulation of Gene_expression of CASP3 35 0.70 28.37 6.45
193 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41
194 INT13406 Negative_regulation of CASP1 25 0.57 10.61 6.36
195 INT275265 Negative_regulation of Positive_regulation of Tnfrsf1a 1 0.56 4.41 6.35
196 INT22901 Negative_regulation of Gene_expression of Esr1 30 0.42 20.92 6.29
197 INT90077 Gene_expression of Casp1 29 0.76 20.79 6.26
198 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25
199 INT38595 Localization of BCAR1 8 0.73 2.9 6.25
200 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
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