GO:0043004

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Name cytoplasmic sequestering of CFTR protein
Categary Process
Go Slim No
Go Link GO:0043004
Unique Molecular Interactions 201
Total Molecular Interactions 261
Total Single Events 2503
Pain Genes Associated 1

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cytoplasmic sequestering of CFTR protein. They are ordered first by their pain relevance and then by number of times they were reported for cytoplasmic sequestering of CFTR protein. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT221181 Binding of GOPC and Flna 1 0.03 0.06 2.08
2 INT336556 SLC6A3 Positive_regulation of Gene_expression of GOPC 1 0.08 1.87 1.76
3 INT266771 Binding of NGF and GOPC 1 0.05 3.23 1.43
4 INT220751 EGF Regulation of GOPC 1 0.08 0 1.18
5 INT220753 Negative_regulation of EGF Regulation of GOPC 1 0.08 0 1.18
6 INT336559 SLC6A3 Positive_regulation of GOPC 1 0.08 1 1.15
7 INT266742 GOPC Regulation of Positive_regulation of ACR 1 0.02 0.36 1.05
8 INT306823 Binding of E2F4 and GOPC 1 0.06 0.23 0.91
9 INT269455 Binding of RAB5A and GOPC 1 0.08 0 0.82
10 INT293011 GPM6A Regulation of GOPC 1 0.00 0 0.81
11 INT269454 Positive_regulation of Binding of GOPC and HHIP 1 0.01 0 0.73
12 INT220746 EGF Positive_regulation of Gene_expression of GOPC 1 0.13 0 0.72
13 INT264946 Binding of FPR1 and GOPC 1 0.08 0.21 0.64
14 INT318981 Binding of CALR and GOPC 1 0.03 0.77 0.64
15 INT264952 Binding of GOPC and BOC 1 0.05 0.22 0.64
16 INT336557 SLC6A3 Positive_regulation of Binding of GOPC 1 0.08 0.5 0.58
17 INT351581 Binding of ALB and GOPC 1 0.11 0 0.55
18 INT352891 Binding of ROS1 and GOPC 1 0.09 1.34 0.53
19 INT269449 Positive_regulation of Binding of RAB5A and GOPC 1 0.11 0 0.53
20 INT269442 Binding of GOPC and HHIP 1 0.01 0 0.52
21 INT264945 GOPC Positive_regulation of Positive_regulation of FPR1 1 0.10 0.2 0.44
22 INT356199 GOPC Positive_regulation of Acot7 1 0.04 0.33 0.4
23 INT338085 Binding of PYCARD and GOPC 1 0.05 0 0.39
24 INT219684 Binding of MMP12 and GOPC 1 0.09 3.11 0.38
25 INT219683 Binding of CEL and GOPC 1 0.04 3.11 0.38
26 INT293201 GOPC Positive_regulation of Gene_expression of IFN1@ 1 0.14 0.18 0.36
27 INT250252 Binding of SLC1A2 and GOPC 1 0.05 0.44 0.35
28 INT250242 Binding of AQP4 and GOPC 1 0.06 0.39 0.35
29 INT250254 Binding of SLC1A3 and GOPC 1 0.02 0.44 0.35
30 INT306822 Binding of E2F2 and GOPC 1 0.05 0.53 0.35
31 INT224822 Binding of ENOX1 and GOPC 1 0.00 0.34 0.34
32 INT344923 Binding of CEBPZ and GOPC 1 0.06 0.24 0.33
33 INT264804 Binding of CNNM2 and GOPC 1 0.00 0.18 0.3
34 INT187110 Binding of TIMP2 and GOPC 1 0.07 0.64 0.29
35 INT266766 Binding of PGR and GOPC 1 0.00 1.08 0.29
36 INT187147 Positive_regulation of Binding of CXCL10 and GOPC 1 0.08 0.53 0.28
37 INT291201 Regulation of INS Positive_regulation of GOPC 1 0.00 0.35 0.28
38 INT352894 Negative_regulation of Binding of ROS1 and GOPC 1 0.08 0.67 0.28
39 INT291200 INS Positive_regulation of GOPC 1 0.01 0.3 0.28
40 INT187143 Binding of CXCL10 and GOPC 1 0.06 0.53 0.28
41 INT352895 Positive_regulation of Binding of ROS1 and GOPC 1 0.08 0.68 0.26
42 INT270277 Binding of NPBWR1 and GOPC 1 0.07 0 0.25
43 INT318980 Binding of CALR and Positive_regulation of Localization of GOPC 1 0.04 0.32 0.24
44 INT184403 Positive_regulation of GOPC Regulation of Gene_expression of KRT20 1 0.00 1.21 0.24
45 INT188195 GOPC Positive_regulation of MAPK1 2 0.21 0.32 0.22
46 INT249665 Binding of GOPC and PSS 1 0.02 3.13 0.21
47 INT186781 Binding of NRIP1 and GOPC 1 0.05 0.49 0.2
48 INT313648 ISYNA1 Regulation of GOPC 1 0.02 0.08 0.2
49 INT236338 Negative_regulation of Binding of PCSK1 and GOPC 1 0.06 0.19 0.2
50 INT293056 Binding of ANXA5 and GOPC 1 0.06 0.51 0.19
51 INT299113 Binding of INPP5K and GOPC 1 0.18 2.69 0.19
52 INT229634 GOPC Positive_regulation of GAST 1 0.09 0.47 0.19
53 INT179158 ATM Regulation of Gene_expression of GOPC 1 0.01 0 0.18
54 INT229042 GOPC Regulation of IL32 1 0.03 1.22 0.17
55 INT294110 Binding of CALCRL and GOPC 1 0.00 0 0.17
56 INT236339 Binding of PCSK1 and GOPC 1 0.05 0.14 0.17
57 INT229039 GOPC Regulation of Gene_expression of IL32 1 0.03 1.18 0.17
58 INT191337 Binding of IDO1 and GOPC 1 0.01 0.65 0.16
59 INT257986 Binding of PTGER2 and GOPC 1 0.04 0.42 0.16
60 INT191336 Binding of TSPO and GOPC 1 0.01 0.65 0.16
61 INT178704 GOPC Positive_regulation of Srr 1 0.02 0 0.16
62 INT178703 Regulation of GOPC Positive_regulation of Srr 1 0.02 0 0.16
63 INT254497 GOPC Regulation of Transcription of HNF4A 1 0.02 0.72 0.16
64 INT249833 Binding of CHI3L1 and GOPC 1 0.06 1.11 0.15
65 INT264868 Binding of COL1A2 and GOPC 1 0.02 0.3 0.15
66 INT238331 PDGFA Regulation of Gene_expression of GOPC 1 0.04 0 0.14
67 INT238330 Binding of PDGFA and Regulation of Gene_expression of GOPC 1 0.06 0 0.14
68 INT272024 Gene_expression of GOPC Positive_regulation of Localization of COL7A1 1 0.10 0.86 0.14
69 INT238338 Binding of EGF and Regulation of Gene_expression of GOPC 1 0.05 0 0.14
70 INT238341 GOPC Regulation of Transcription of ADAMTS1 1 0.04 0 0.14
71 INT238337 EGF Regulation of Gene_expression of GOPC 1 0.03 0 0.14
72 INT340109 GOPC Positive_regulation of Ltp 1 0.01 0.19 0.14
73 INT238334 GOPC Regulation of Transcription of ADAMTS5 1 0.04 0 0.14
74 INT246364 GOPC Regulation of SETBP1 1 0.02 0.98 0.13
75 INT299553 GOPC Positive_regulation of Stat3 1 0.02 0 0.13
76 INT181929 GOPC Regulation of Gene_expression of TIMP1 1 0.00 0 0.12
77 INT223482 CRP Positive_regulation of GOPC 1 0.08 0.8 0.1
78 INT313486 GOPC Positive_regulation of P2RX1 1 0.13 0 0.1
79 INT249183 Binding of ITPR3 and GOPC 2 0.01 0.26 0.09
80 INT243465 Binding of GH1 and GOPC 1 0.02 0.99 0.09
81 INT274470 Binding of IL12A and GOPC 1 0.02 0.6 0.09
82 INT201446 GOPC Positive_regulation of Slc6a3 1 0.03 0.07 0.08
83 INT254496 Binding of HNF4A and GOPC 1 0.10 0.34 0.08
84 INT210364 Binding of FUT1 and GOPC 1 0.01 0.53 0.08
85 INT254498 Binding of SREBF1 and GOPC 1 0.05 0.34 0.08
86 INT254495 Binding of PPARA and GOPC 1 0.04 0.34 0.08
87 INT249166 Phosphorylation of NCF1 Positive_regulation of Localization of GOPC 1 0.03 0.06 0.08
88 INT353666 Gene_expression of CD209 Negative_regulation of GOPC 1 0.06 0.67 0.08
89 INT352358 CD86 Positive_regulation of GOPC 1 0.30 0.13 0.07
90 INT266662 TIMP1 Regulation of Gene_expression of GOPC 1 0.06 0.11 0.06
91 INT328426 PRB4 Positive_regulation of GOPC 1 0.03 0.55 0.05
92 INT203638 Binding of MR1 and GOPC 1 0.04 1.43 0.05
93 INT347072 GOPC Positive_regulation of Gene_expression of IL6 1 0.01 0.38 0.04
94 INT266445 Binding of HEY1 and GOPC 1 0.00 2.92 0.04
95 INT170668 GOPC Regulation of CRP 1 0.07 0.32 0.04
96 INT282556 POU5F1 Positive_regulation of GOPC 1 0.06 0.06 0.04
97 INT266452 Binding of Acot1 and GOPC 1 0.02 1.23 0.04
98 INT170666 GOPC Regulation of ANGPTL5 1 0.06 0.32 0.04
99 INT296712 Binding of H2-K1 and GOPC 1 0.00 0.41 0.04
100 INT309727 Binding of C2 and GOPC 1 0.03 0 0.04
101 INT281652 GOPC Positive_regulation of C3 1 0.22 0.22 0.04
102 INT257992 PTGER2 Negative_regulation of GOPC 1 0.04 0 0.03
103 INT185651 GOPC Positive_regulation of AR 1 0.03 0.06 0.03
104 INT316218 GOPC Positive_regulation of BDKRB2 1 0.08 0.71 0.03
105 INT291786 GOPC Negative_regulation of Gene_expression of Gnat3 1 0.01 0 0.03
106 INT237155 LGALS4 Regulation of Gene_expression of GOPC 1 0.05 0 0.03
107 INT192914 Binding of ESR1 and GOPC 2 0.02 0.61 0
108 INT309744 Binding of GOPC and TRPV4 1 0.09 0 0
109 INT308122 Binding of F13A1 and GOPC 1 0.01 0.25 0
110 INT200642 GOPC Regulation of AKT1 1 0.14 0.2 0
111 INT292679 GOPC Positive_regulation of HSP90AA1 1 0.01 0.1 0
112 INT210829 Binding of POMC and GOPC 1 0.06 0.15 0
113 INT238823 LTF Positive_regulation of GOPC 1 0.01 0.29 0
114 INT306114 GOPC Regulation of Gene_expression of FGF7 1 0.05 0.45 0
115 INT313293 Binding of KEAP1 and GOPC 1 0.04 0.24 0
116 INT329568 GOPC Positive_regulation of Phosphorylation of MAPK1 1 0.04 0.79 0
117 INT269578 GOPC Positive_regulation of Phosphorylation of PTGIR 1 0.01 0 0
118 INT267261 GOPC Regulation of BMI1 1 0.06 0.75 0
119 INT278761 Binding of KBTBD10 and GOPC 1 0.14 0 0
120 INT177283 Binding of CXADR and GOPC 1 0.16 0 0
121 INT339800 P2RX1 Regulation of Negative_regulation of GOPC 1 0.04 0 0
122 INT278763 Binding of HOXA9 and GOPC 1 0.14 0 0
123 INT288002 Binding of COL2A1 and GOPC 1 0.12 0 0
124 INT224023 Binding of GOPC and P2RY12 1 0.02 0.69 0
125 INT278186 Binding of TP53 and GOPC 1 0.02 0.85 0
126 INT170587 GOPC Regulation of Gene_expression of ICAM1 1 0.13 0 0
127 INT298868 Binding of RAB7A and GOPC 1 0.07 1.64 0
128 INT313304 Binding of SQSTM1 and GOPC 1 0.04 0.24 0
129 INT241266 DNMT3B Positive_regulation of Gene_expression of GOPC 1 0.05 0.68 0
130 INT249666 Binding of CD81 and GOPC 1 0.06 1.31 0
131 INT298301 Binding of BDNF and GOPC 1 0.03 0.47 0
132 INT269549 Regulation of GOPC Positive_regulation of RHOA 1 0.09 0 0
133 INT327970 GOPC Regulation of Gene_expression of BAD 1 0.08 0.6 0
134 INT198007 MTOR Regulation of Gene_expression of GOPC 1 0.08 1.33 0
135 INT349954 ARMC9 Regulation of GOPC 1 0.00 0 0
136 INT293814 Negative_regulation of ERBB2 Negative_regulation of Gene_expression of GOPC 1 0.02 0 0
137 INT309749 Binding of CA2 and GOPC 1 0.03 0 0
138 INT177290 GOPC Positive_regulation of CYP3A4 1 0.15 0 0
139 INT214890 GOPC Positive_regulation of CDKN1A 1 0.06 0.57 0
140 INT264978 Binding of BAG3 and GOPC 1 0.18 0.38 0
141 INT269571 Positive_regulation of GOPC Positive_regulation of RHOA 1 0.10 0 0
142 INT241259 DNMT3B Positive_regulation of GOPC 1 0.05 0.68 0
143 INT293412 GOPC Regulation of Localization of VEGFA 1 0.04 0.61 0
144 INT308124 GOPC Regulation of F13A1 1 0.01 0.25 0
145 INT265743 Binding of VEGFA and GOPC 1 0.15 0 0
146 INT269580 TMPO Positive_regulation of GOPC 1 0.05 0 0
147 INT175192 Binding of NUP62 and GOPC 1 0.03 0 0
148 INT170459 Binding of CD1A and GOPC 1 0.07 0.1 0
149 INT184196 GOPC Negative_regulation of HYAL1 1 0.02 0 0
150 INT269555 GOPC Positive_regulation of RHOA 1 0.10 0 0
151 INT236017 GOPC Positive_regulation of MAPK8 1 0.09 0.17 0
152 INT265758 GOPC Positive_regulation of Gene_expression of FLT1 1 0.14 0 0
153 INT235018 Binding of DSP and GOPC 1 0.02 0.19 0
154 INT185652 Binding of AR and GOPC 1 0.03 0 0
155 INT269594 GOPC Positive_regulation of Phosphorylation of CFL1 1 0.04 0 0
156 INT331883 Binding of MAGEA4 and GOPC 1 0.03 0 0
157 INT265765 Binding of NRP1 and GOPC 1 0.13 0 0
158 INT221957 Binding of UTS2R and GOPC 1 0.02 0.08 0
159 INT191540 Binding of ABCA3 and GOPC 1 0.03 0.12 0
160 INT249175 Binding of CISH and GOPC 1 0.01 0.26 0
161 INT210286 Binding of ELAVL4 and GOPC 1 0.06 0.87 0
162 INT313946 Binding of PEE1 and GOPC 1 0.07 0.44 0
163 INT286593 Binding of Pkd1 and GOPC 1 0.02 1.13 0
164 INT236010 GOPC Positive_regulation of AKT1 1 0.03 0.17 0
165 INT269562 GOPC Positive_regulation of Gene_expression of EPHA3 1 0.03 0 0
166 INT292510 Mlph Regulation of Gene_expression of GOPC 1 0.00 0.41 0
167 INT313303 Negative_regulation of SQSTM1 Positive_regulation of GOPC 1 0.05 0.39 0
168 INT292725 GOPC Positive_regulation of Protein_catabolism of Akt1 1 0.01 0.1 0
169 INT306566 Binding of IGHE and GOPC 1 0.06 0.18 0
170 INT327975 GOPC Regulation of Gene_expression of BAX 1 0.15 0.6 0
171 INT229043 Gene_expression of GOPC Negative_regulation of Gene_expression of IL32 1 0.02 0 0
172 INT230415 GOPC Regulation of MSLN 1 0.03 0.09 0
173 INT210287 Binding of CD8A and GOPC 1 0.07 0.87 0
174 INT265770 Binding of KDR and GOPC 1 0.10 0 0
175 INT269576 Negative_regulation of GOPC Positive_regulation of RHOA 1 0.08 0 0
176 INT238820 LTF Positive_regulation of Localization of GOPC 1 0.01 0.29 0
177 INT241269 DNMT1 Positive_regulation of Gene_expression of GOPC 1 0.04 0.68 0
178 INT293413 GOPC Regulation of Localization of IL11 1 0.03 0.6 0
179 INT271767 GOPC Regulation of MUC1 1 0.02 0 0
180 INT265766 GOPC Positive_regulation of Gene_expression of VEGFA 1 0.16 0 0
181 INT191258 Binding of LRPAP1 and GOPC 1 0.01 0 0
182 INT327974 GOPC Regulation of Gene_expression of BCL2 1 0.13 0.6 0
183 INT208639 Binding of NCAM1 and GOPC 1 0.12 0.28 0
184 INT309753 Binding of CALM3 and GOPC 1 0.04 0 0
185 INT241254 DNMT1 Positive_regulation of GOPC 1 0.04 0.68 0
186 INT278774 Binding of PLN and GOPC 1 0.14 0 0
187 INT320958 Binding of KRT31 and GOPC 1 0.01 0.52 0
188 INT252908 Binding of PTTG3P and GOPC 1 0.01 0.08 0
189 INT282544 GOPC Regulation of REXO1 1 0.03 0 0
190 INT269563 GOPC Positive_regulation of Gene_expression of TMPO 1 0.05 0 0
191 INT234797 AVP Regulation of GOPC 1 0.01 0.65 0
192 INT308123 Regulation of Binding of F13A1 and GOPC 1 0.00 0.25 0
193 INT184211 GOPC Negative_regulation of Gene_expression of ADAMTS5 1 0.07 0 0
194 INT231520 Binding of PAX7 and GOPC 1 0.09 0.98 0
195 INT224025 Binding of WDTC1 and GOPC 1 0.00 0.69 0
196 INT265774 Binding of FLT1 and GOPC 1 0.12 0 0
197 INT317778 Binding of ADRB2 and GOPC 1 0.10 0.69 0
198 INT177762 GOPC Negative_regulation of Gene_expression of CHKB 1 0.11 0.08 0
199 INT251928 GOPC Regulation of Gene_expression of ALPP 1 0.06 0 0
200 INT265769 GOPC Positive_regulation of Gene_expression of KL 1 0.08 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cytoplasmic sequestering of CFTR protein. They are ordered first by their pain relevance and then by number of times they were reported in cytoplasmic sequestering of CFTR protein. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6
2 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75
3 INT15610 Localization of GOPC 223 0.65 68.26 28.7
4 INT105021 Binding of GOPC 187 0.40 60.39 20.38
5 INT171666 Regulation of GOPC 117 0.39 40.41 15.47
6 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41
7 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68
8 INT178754 Positive_regulation of Localization of GOPC 32 0.43 10.1 4.73
9 INT170604 Negative_regulation of Gene_expression of GOPC 50 0.35 12.71 4.51
10 INT170606 Regulation of Gene_expression of GOPC 31 0.37 6.08 3.31
11 INT180971 Protein_catabolism of GOPC 21 0.77 6.15 2.98
12 INT169987 Transcription of GOPC 45 0.60 21.88 2.61
13 INT174979 Phosphorylation of GOPC 45 0.51 10.11 2.28
14 INT230716 Regulation of Binding of GOPC 2 0.10 0.26 1.59
15 INT181003 Negative_regulation of Localization of GOPC 11 0.30 1.93 1.22
16 INT188396 Positive_regulation of Positive_regulation of GOPC 13 0.42 1.78 1.21
17 INT180183 Regulation of Positive_regulation of GOPC 4 0.26 1.47 0.96
18 INT184418 Negative_regulation of Positive_regulation of GOPC 15 0.26 5.47 0.87
19 INT209108 Positive_regulation of Negative_regulation of GOPC 6 0.33 1.72 0.51
20 INT192587 Negative_regulation of Protein_catabolism of GOPC 4 0.22 1.15 0.41
21 INT188228 Positive_regulation of Phosphorylation of GOPC 7 0.29 0.72 0.4
22 INT171922 Positive_regulation of Binding of GOPC 5 0.44 1.31 0.34
23 INT180182 Negative_regulation of Negative_regulation of GOPC 2 0.25 1.58 0.24
24 INT178840 Regulation of Localization of GOPC 5 0.25 0.78 0.14
25 INT185720 Positive_regulation of Transcription of GOPC 1 0.06 0.23 0.12
26 INT246199 Negative_regulation of Phosphorylation of GOPC 10 0.18 2.18 0.11
27 INT237839 Negative_regulation of Transcription of GOPC 4 0.37 0.29 0.05
28 INT180973 Positive_regulation of Protein_catabolism of GOPC 1 0.17 0.67 0.03
29 INT175216 Negative_regulation of Binding of GOPC 5 0.10 2.05 0
30 INT277160 Positive_regulation of Regulation of GOPC 2 0.10 0.86 0
31 INT299728 Regulation of Transcription of GOPC 1 0.38 0 0
32 INT292476 Regulation of Phosphorylation of GOPC 1 0.04 0.63 0
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