GO:0043008

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Name ATP-dependent protein binding
Categary Function
Go Slim No
Go Link GO:0043008
Unique Molecular Interactions 95
Total Molecular Interactions 125
Total Single Events 1771
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ATP-dependent protein binding. They are ordered first by their pain relevance and then by number of times they were reported for ATP-dependent protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT281085 Binding of Gria2 and Nsf 2 0.26 0.4 0.94
2 INT113610 Binding of Nsf and Grip2 1 0.24 0.6 0.63
3 INT281079 Binding of Nsf and Gria3 1 0.19 0.05 0.61
4 INT255287 Binding of Stx1a and Vti1b 1 0.35 0 0.58
5 INT335594 Myo5a Regulation of Hmmr 1 0.00 0.39 0.45
6 INT328184 Positive_regulation of Slc3a1 Positive_regulation of Nsf 1 0.00 0.15 0.43
7 INT328183 Slc3a1 Positive_regulation of Nsf 1 0.00 0.15 0.43
8 INT231303 Binding of Prnp and Helt 1 0.02 3.23 0.41
9 INT231304 Prnp Negative_regulation of Grin2d 2 0.38 0.5 0.4
10 INT100598 PRNP Positive_regulation of Gene_expression of IL6 1 0.40 0.23 0.4
11 INT255285 Binding of Snap25 and Stx1a 1 0.07 0 0.33
12 INT231306 Prnp Regulation of Grin1 1 0.60 0.35 0.31
13 INT191240 SAE1 Regulation of Localization of INS 1 0.08 1.15 0.3
14 INT255291 Binding of Napb and Stx1a 1 0.21 0 0.29
15 INT290847 Regulation of Binding of Stx1a and Fig4 1 0.05 0.26 0.24
16 INT244056 Nsf Regulation of Gabarap 1 0.05 0.09 0.24
17 INT244023 Nsf Regulation of Camk2a 1 0.04 0.09 0.24
18 INT316111 APC Negative_regulation of SAE1 1 0.04 1.21 0.22
19 INT290846 Binding of Stx1a and Fig4 1 0.07 0.26 0.22
20 INT57964 Myo5a Regulation of Negative_regulation of Cyp1a1 1 0.00 0.1 0.2
21 INT316110 Binding of APC and SAE1 1 0.03 1.16 0.2
22 INT231305 Positive_regulation of Binding of Prnp and Helt 1 0.03 1.63 0.19
23 INT287764 Binding of Gria2 and Nsf 1 0.34 0.33 0.18
24 INT191241 SST Regulation of SAE1 1 0.05 0.89 0.18
25 INT272607 Binding of Dnahc8 and Nsf 1 0.02 0.42 0.14
26 INT272605 Binding of Dlg4 and Nsf 1 0.36 0.41 0.14
27 INT134698 Regulation of Prnp Positive_regulation of Nup214 1 0.26 1.18 0.14
28 INT134697 Prnp Positive_regulation of Nup214 1 0.44 1.18 0.13
29 INT125745 Nsf Negative_regulation of Dnahc8 1 0.06 0.33 0.1
30 INT231301 Prnp Regulation of Regulation of Grin1 1 0.26 0.24 0.08
31 INT207310 Pik3r1 Positive_regulation of Prnp 1 0.36 0.65 0.08
32 INT316112 Binding of S100B and SAE1 1 0.05 1.5 0.08
33 INT229539 Cpz Negative_regulation of Localization of Prnp 1 0.05 0.58 0.07
34 INT57965 Myo5a Negative_regulation of Cyp2e1 1 0.01 0.09 0.07
35 INT229538 Cpz Negative_regulation of Positive_regulation of Prnp 1 0.05 0.58 0.07
36 INT250153 Binding of PRNP and IKBKG 1 0.09 2.83 0.06
37 INT231300 Positive_regulation of Grin2b Positive_regulation of Prnp 1 0.39 0.16 0.05
38 INT231299 Prnp Regulation of Grin2d 1 0.28 0 0.05
39 INT244031 Binding of Gabrg2 and Nsf 1 0.04 0.19 0.05
40 INT251944 Binding of GH1 and PRNP 1 0.09 1.14 0.05
41 INT231302 Binding of Grin2d and Prnp 1 0.38 0.11 0.05
42 INT244016 Binding of Nsf and Gabarap 1 0.07 0.19 0.05
43 INT249421 Binding of Stx1a and Vamp2 1 0.10 0 0.04
44 INT249414 Binding of Stx1a and Dcaf12l2 1 0.00 0 0.04
45 INT231311 Prnp Negative_regulation of Helt 1 0.04 0.05 0.03
46 INT231308 Prnp Negative_regulation of Gene_expression of Grin1 1 0.41 0.05 0.03
47 INT231312 Prnp Negative_regulation of Grin1 1 0.42 0.05 0.03
48 INT260518 Binding of Prnp and Gopc 2 0.13 1.06 0
49 INT268647 ATP2B3 Positive_regulation of Prnp 1 0.01 0.57 0
50 INT249417 Binding of Stx1a and Napa 1 0.13 0 0
51 INT335952 Prnp Positive_regulation of can 1 0.17 0.58 0
52 INT218240 Binding of SAE1 and Dync1h1 1 0.00 0.17 0
53 INT268183 Gene_expression of Rab22a Negative_regulation of Gene_expression of Prnp 1 0.28 0.1 0
54 INT249426 Mbp Positive_regulation of Stx1a 1 0.10 0.11 0
55 INT297245 Prnp Positive_regulation of Notch1 1 0.21 0.73 0
56 INT354566 F2 Positive_regulation of PRNP 1 0.00 0.05 0
57 INT260523 Binding of Cnp and Prnp 1 0.33 0.34 0
58 INT240420 Myo5a Positive_regulation of CD4 1 0.06 0.27 0
59 INT193308 Binding of PRNP and TGFB1 1 0.01 0 0
60 INT268192 Gene_expression of Rab22a Positive_regulation of Protein_catabolism of Prnp 1 0.30 0.08 0
61 INT260561 Binding of AFM and PRNP 1 0.22 0 0
62 INT260519 Binding of Prnp and Scarb1 1 0.41 0.21 0
63 INT268191 Rab4a Regulation of Gene_expression of Prnp 1 0.23 0.22 0
64 INT255167 Binding of SAE1 and CERS1 1 0.08 0.72 0
65 INT295044 Klra8 Positive_regulation of Gene_expression of Sae1 1 0.00 2.18 0
66 INT260522 Binding of Myc and Prnp 1 0.30 0.35 0
67 INT335950 Negative_regulation of Prnp Positive_regulation of can 1 0.16 0.59 0
68 INT268197 Gene_expression of Rab22a Regulation of Prnp 1 0.29 0.08 0
69 INT268184 Prnp Regulation of Gene_expression of Rab22a 1 0.34 0.17 0
70 INT281321 STX1A Positive_regulation of Gene_expression of tf 1 0.07 0.96 0
71 INT249408 Mbp Positive_regulation of Localization of Stx1a 1 0.11 0.33 0
72 INT231313 Prnp Positive_regulation of Grin2d 1 0.47 0.16 0
73 INT268201 Tg(CAG-EGFP)D4Nagy Regulation of Prnp 1 0.01 0.22 0
74 INT268198 Prnp Positive_regulation of Erc1 1 0.04 0.26 0
75 INT268194 Erc1 Positive_regulation of Gene_expression of Prnp 1 0.05 0.2 0
76 INT249405 Binding of Mbp and Stx1a 1 0.11 0 0
77 INT344000 PROC Positive_regulation of PRNP 1 0.00 0.07 0
78 INT268190 Gene_expression of Rab22a Negative_regulation of Prnp 1 0.32 0.08 0
79 INT249420 Stx1a Positive_regulation of Binding of Snap25 1 0.13 0 0
80 INT249410 Vamp2 Regulation of Binding of Stx1a 1 0.06 0 0
81 INT268177 Rab4a Regulation of Prnp 1 0.14 0.22 0
82 INT268182 Positive_regulation of Binding of Prnp and Erc1 1 0.06 0.1 0
83 INT182774 Binding of ETV3 and SAE1 1 0.00 1.17 0
84 INT268188 Binding of Prnp and Erc1 1 0.04 0.27 0
85 INT268185 Rab22a Negative_regulation of Gene_expression of Prnp 1 0.32 0.08 0
86 INT268195 Rab22a Negative_regulation of Prnp 1 0.44 0.09 0
87 INT193307 Binding of PDGFA and PRNP 1 0.01 0 0
88 INT268176 Positive_regulation of Erc1 Positive_regulation of Gene_expression of Prnp 1 0.06 0.2 0
89 INT287034 Pgp Regulation of Positive_regulation of Prnp 1 0.13 0.09 0
90 INT131787 Binding of Myo5a and Pon1 1 0.02 0.06 0
91 INT268646 Prnp Positive_regulation of PRNP 1 0.08 0.42 0
92 INT351708 Binding of LMNA and SAE1 1 0.08 0 0
93 INT354482 Binding of PRNP and Prnp 1 0.16 0.88 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ATP-dependent protein binding. They are ordered first by their pain relevance and then by number of times they were reported in ATP-dependent protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5
2 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34
3 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25
4 INT55957 Positive_regulation of PRNP 57 0.67 37.87 7.11
5 INT114993 Binding of Myo5a 15 0.30 11.46 5.48
6 INT69572 Localization of Prnp 96 0.81 38.11 5.45
7 INT125996 Gene_expression of Nsf 7 0.75 1.73 5.3
8 INT102254 Positive_regulation of Gene_expression of Prnp 72 0.70 38.11 4.81
9 INT69570 Binding of Prnp 75 0.48 44.26 4.37
10 INT102255 Regulation of Prnp 35 0.62 18.97 3.25
11 INT160251 Gene_expression of Myo5a 48 0.63 37.14 3.16
12 INT144068 Binding of Nsf 9 0.48 7.67 3.16
13 INT102253 Negative_regulation of Prnp 75 0.59 24.23 2.62
14 INT132271 Positive_regulation of Gene_expression of Nsf 1 0.45 0.51 2.46
15 INT135040 Regulation of Gene_expression of Prnp 30 0.62 10.52 2.45
16 INT132270 Regulation of Gene_expression of Nsf 1 0.44 0.46 2.3
17 INT113608 Positive_regulation of Nsf 2 0.39 1.03 2.22
18 INT167203 Binding of PRNP 25 0.48 20.09 1.84
19 INT125743 Negative_regulation of Nsf 5 0.58 3.07 1.71
20 INT171816 Gene_expression of Stx1a 5 0.20 1.67 1.65
21 INT22785 Negative_regulation of PRNP 12 0.57 5.09 1.57
22 INT311241 Transcription of Myo5a 1 0.50 1.61 1.37
23 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36
24 INT85621 Regulation of PRNP 16 0.60 8.7 1.15
25 INT158140 Regulation of Nsf 3 0.45 2.85 1.09
26 INT157921 Gene_expression of Nsf 3 0.58 2.31 1.09
27 INT204737 Negative_regulation of Gene_expression of Prnp 32 0.59 18.96 1.03
28 INT192785 Regulation of Myo5a 4 0.05 9.05 0.93
29 INT201222 Positive_regulation of STX1A 1 0.45 0.51 0.93
30 INT132269 Transcription of Nsf 1 0.45 0.19 0.89
31 INT132268 Positive_regulation of Transcription of Nsf 1 0.39 0.19 0.89
32 INT171818 Localization of Stx1a 1 0.08 0.22 0.85
33 INT136634 Transcription of Prnp 9 0.72 3.34 0.83
34 INT125989 Negative_regulation of Gene_expression of Nsf 1 0.41 0.06 0.79
35 INT57958 Positive_regulation of Myo5a 9 0.41 7.52 0.77
36 INT166010 Positive_regulation of Nsf 2 0.38 1.76 0.72
37 INT100601 Localization of PRNP 17 0.66 13.61 0.71
38 INT213381 Gene_expression of STX1A 5 0.65 3.41 0.71
39 INT190662 Regulation of Positive_regulation of Prnp 4 0.24 1.15 0.7
40 INT69571 Positive_regulation of Positive_regulation of Prnp 6 0.70 5.88 0.67
41 INT320096 Negative_regulation of SAE1 10 0.12 3.85 0.59
42 INT124164 Protein_catabolism of Prnp 20 1.00 8.58 0.44
43 INT328192 Positive_regulation of Positive_regulation of Nsf 1 0.05 0.15 0.43
44 INT249396 Binding of Stx1a 9 0.15 0.23 0.42
45 INT234083 Gene_expression of Stx1a 10 0.64 1.41 0.41
46 INT182790 Positive_regulation of SAE1 3 0.49 3.18 0.39
47 INT195574 Localization of Myo5a 4 0.34 1.1 0.36
48 INT251949 Negative_regulation of Gene_expression of PRNP 6 0.43 4.16 0.3
49 INT191243 Binding of SAE1 4 0.35 2.88 0.29
50 INT335949 Positive_regulation of Positive_regulation of PRNP 2 0.25 0.82 0.29
51 INT229518 Phosphorylation of Prnp 5 0.69 1.62 0.27
52 INT331055 Positive_regulation of Phosphorylation of Prnp 1 0.07 0.24 0.27
53 INT69568 Positive_regulation of Localization of Prnp 5 0.50 2.43 0.26
54 INT115708 Phosphorylation of PRNP 2 0.71 1.61 0.26
55 INT334791 Binding of Nsf 1 0.12 0.39 0.26
56 INT268171 Negative_regulation of Binding of Prnp 3 0.42 0.82 0.25
57 INT156424 Localization of Nsf 1 0.65 1.01 0.25
58 INT290851 Regulation of Stx1a 1 0.09 0.26 0.24
59 INT225439 Gene_expression of Sae1 4 0.08 9.81 0.21
60 INT240411 Negative_regulation of Binding of Myo5a 1 0.09 0.97 0.21
61 INT64080 Positive_regulation of Stx1a 3 0.08 0 0.2
62 INT328187 Regulation of Nsf 1 0.04 0 0.18
63 INT325414 Regulation of Regulation of PRNP 1 0.26 0.7 0.16
64 INT64081 Regulation of Stx1a 3 0.25 0.07 0.14
65 INT192783 Phosphorylation of Myo5a 1 0.04 2.01 0.12
66 INT290852 Binding of Stx1a 1 0.13 0 0.11
67 INT334306 Positive_regulation of Stx1a 1 0.10 0.65 0.11
68 INT320951 Negative_regulation of Gene_expression of Stx1a 1 0.40 0.56 0.11
69 INT190664 Regulation of Binding of Prnp 3 0.52 4.29 0.1
70 INT207304 Positive_regulation of Protein_catabolism of Prnp 9 0.69 2.08 0.09
71 INT316114 Gene_expression of SAE1 6 0.14 2.95 0.09
72 INT160258 Negative_regulation of Myo5a 3 0.35 3.96 0.09
73 INT293049 Positive_regulation of Localization of PRNP 1 0.07 2.67 0.09
74 INT191244 Localization of SAE1 1 0.12 2.81 0.09
75 INT241393 Regulation of Gene_expression of Sae1 1 0.06 0.68 0.09
76 INT303459 Transcription of PRNP 4 0.69 1.44 0.08
77 INT354480 Regulation of Gene_expression of PRNP 1 0.39 1.96 0.08
78 INT354479 Positive_regulation of Transcription of PRNP 1 0.50 0.4 0.08
79 INT207302 Positive_regulation of Transcription of Prnp 1 0.47 0.71 0.06
80 INT125744 Negative_regulation of Negative_regulation of Nsf 1 0.43 0.27 0.05
81 INT229516 Negative_regulation of Positive_regulation of Prnp 5 0.42 0.95 0.04
82 INT192784 Positive_regulation of Gene_expression of Myo5a 2 0.45 3.39 0.04
83 INT320948 Negative_regulation of Stx1a 1 0.41 0.41 0.04
84 INT229519 Regulation of Localization of Prnp 4 0.61 0.7 0.03
85 INT320098 Negative_regulation of Gene_expression of SAE1 1 0.09 0.65 0.03
86 INT293047 Protein_catabolism of PRNP 1 0.57 2 0.03
87 INT287031 Positive_regulation of Negative_regulation of Prnp 1 0.46 0.16 0.03
88 INT320097 Regulation of Gene_expression of SAE1 1 0.09 0.65 0.03
89 INT268144 Negative_regulation of Localization of Prnp 3 0.37 0.71 0
90 INT243247 Localization of Stx1a 3 0.42 0.53 0
91 INT190666 Positive_regulation of Binding of Prnp 2 0.50 1.87 0
92 INT268161 Regulation of Negative_regulation of Prnp 2 0.39 0.33 0
93 INT225372 Regulation of Sae1 2 0.00 1.47 0
94 INT249387 Positive_regulation of Regulation of Stx1a 1 0.20 0.07 0
95 INT351709 Protein_catabolism of SAE1 1 0.14 0 0
96 INT229517 Regulation of Phosphorylation of Prnp 1 0.39 0.26 0
97 INT316116 Regulation of SAE1 1 0.07 1.22 0
98 INT188131 Negative_regulation of Regulation of PRNP 1 0.41 0.06 0
99 INT293048 Regulation of Protein_catabolism of PRNP 1 0.06 1.01 0
100 INT286005 Positive_regulation of Binding of Myo5a 1 0.41 0.97 0
101 INT249380 Positive_regulation of Phosphorylation of Stx1a 1 0.19 0.07 0
102 INT344005 Regulation of Positive_regulation of PRNP 1 0.20 0.08 0
103 INT240690 Positive_regulation of Binding of PRNP 1 0.07 0.53 0
104 INT286004 Positive_regulation of Positive_regulation of Myo5a 1 0.41 0.58 0
105 INT252138 Binding of STX1A 1 0.35 0 0
106 INT249400 Negative_regulation of Binding of Stx1a 1 0.17 0.08 0
107 INT249375 Phosphorylation of Stx1a 1 0.33 0.07 0
108 INT351712 Regulation of Binding of SAE1 1 0.09 0 0
109 INT315417 Negative_regulation of Transcription of Prnp 1 0.43 0.14 0
110 INT268173 Negative_regulation of Negative_regulation of Prnp 1 0.37 0 0
111 INT222723 Negative_regulation of Localization of PRNP 1 0.05 2.06 0
112 INT268148 Regulation of Protein_catabolism of Prnp 1 0.45 0 0
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