GO:0043086

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Name negative regulation of catalytic activity
Categary Process
Go Slim No
Go Link GO:0043086
Unique Molecular Interactions 261
Total Molecular Interactions 350
Total Single Events 2647
Pain Genes Associated 44

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of catalytic activity. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of catalytic activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206764 Binding of AQP4 and Nqo1 8 0.05 13.45 2.84
2 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 0.07 1.72 2.46
3 INT169346 Nxn Negative_regulation of Dynll1 1 0.06 1.22 1.87
4 INT243043 Binding of Mmp9 and Timp1 1 0.05 0.25 1.86
5 INT168865 Cd38 Regulation of Wdtc1 1 0.03 0.12 1.35
6 INT194513 Timp1 Negative_regulation of Cpox 1 0.00 0.9 1.31
7 INT94367 Binding of ARRB1 and TP53INP2 1 0.25 0 1.3
8 INT202041 CAMK2N2 Negative_regulation of PPP1R11 1 0.00 0.74 1.25
9 INT140172 Binding of Nqo1 and IgG 5 0.17 6.68 1.2
10 INT196812 Ppp1r1b Negative_regulation of Ppp1cc 3 0.07 0.13 1.12
11 INT174468 IL7 Positive_regulation of Gene_expression of IL4 1 0.40 1.88 1.02
12 INT81329 Binding of ARRB1 and OPRK1 1 0.05 0.1 0.93
13 INT196834 Prkaca Positive_regulation of Phosphorylation of Ppp1r1b 2 0.15 0 0.87
14 INT112914 Ppp1r1b Negative_regulation of Prkaca 3 0.22 0.13 0.86
15 INT48751 Binding of Nqo1 and Npy 1 0.28 0 0.82
16 INT77393 Binding of ARRB1 and OPRM1 1 0.15 0 0.82
17 INT144449 Plscr1 Positive_regulation of Gene_expression of Nqo1 1 0.15 0.18 0.8
18 INT144451 Napa Positive_regulation of Gene_expression of Nqo1 1 0.07 0.18 0.8
19 INT104749 Ugt1a1 Regulation of Positive_regulation of G2e3 1 0.00 0.07 0.77
20 INT104748 Ugt1a1 Regulation of Positive_regulation of LOC100359830 1 0.01 0.07 0.77
21 INT94366 Binding of ARRB1 and OPRD1 1 0.11 0 0.67
22 INT100806 Ppp1r14a Regulation of Ppp1cc 1 0.05 0 0.65
23 INT239488 Spna1 Negative_regulation of Gene_expression of Timp1 1 0.00 0.94 0.62
24 INT346412 Binding of Tesc and Sv2a 1 0.02 0.6 0.59
25 INT73707 Ngf Regulation of Scgb1a1 1 0.25 0.61 0.58
26 INT239489 Spna1 Negative_regulation of Timp1 1 0.00 0.89 0.57
27 INT166840 Binding of Anxa1 and Nfkb1 1 0.26 0.82 0.56
28 INT77394 Binding of ARRB1 and GIPC1 1 0.01 0 0.56
29 INT112916 Nts Regulation of Phosphorylation of Ppp1r1b 1 0.47 0 0.55
30 INT60481 Binding of Ugt1a1 and UGT1A6 1 0.23 0 0.55
31 INT316736 Il1 Positive_regulation of Timp1 1 0.04 0.63 0.54
32 INT302834 Cd4 Positive_regulation of Gene_expression of Il7 1 0.05 1.02 0.54
33 INT174467 IL7 Positive_regulation of IFNA1 1 0.11 1.53 0.53
34 INT184111 Epo Positive_regulation of Il7 1 0.06 0.26 0.52
35 INT196824 Ppp1r1b Regulation of Prkaca 1 0.10 0 0.51
36 INT184096 Il7 Positive_regulation of Stat5a 1 0.07 0.26 0.51
37 INT93951 Nfkb1 Regulation of Gene_expression of Timp1 1 0.00 0.26 0.51
38 INT196826 Ppp1r1b Regulation of Ppp1cc 1 0.10 0 0.51
39 INT302845 Il7 Positive_regulation of Gene_expression of TNF 1 0.01 0.98 0.49
40 INT302820 Stat3 Regulation of Positive_regulation of Il7 1 0.04 1.03 0.49
41 INT302823 Stat3 Regulation of Gene_expression of Il7 1 0.04 1.03 0.49
42 INT81330 ARRB1 Regulation of OPRK1 1 0.04 0.09 0.47
43 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 0.41 1 0.46
44 INT264137 IFNA1 Positive_regulation of Socs1 1 0.01 0.38 0.46
45 INT319554 Sgk1 Regulation of Cdkn1a 1 0.26 0.09 0.45
46 INT228850 Dio1 Positive_regulation of Phosphorylation of Ppp1r1b 1 0.06 0 0.44
47 INT296237 Anxa1 Regulation of Gene_expression of Trpm8 1 0.03 0.57 0.43
48 INT296231 Anxa1 Regulation of Gene_expression of Trpa1 1 0.03 0.57 0.43
49 INT346416 Binding of Tesc and Svs1 1 0.00 0.07 0.42
50 INT296235 Trpm8 Regulation of Positive_regulation of Anxa1 1 0.03 0.62 0.41
51 INT196821 Phosphorylation of Ppp1r1b Positive_regulation of Prkaca 1 0.09 0 0.41
52 INT264135 Socs1 Positive_regulation of Protein_catabolism of TOLLIP 1 0.00 0.33 0.41
53 INT112919 Nts Negative_regulation of Phosphorylation of Ppp1r1b 1 0.28 0 0.4
54 INT231753 Il7 Positive_regulation of TNF 1 0.03 0.66 0.39
55 INT321860 Timp1 Negative_regulation of Icam1 1 0.22 1.13 0.39
56 INT196829 Ppp1r1b Negative_regulation of Phosphorylation of Ppp1cc 1 0.07 0 0.39
57 INT196796 Ppp1r1b Negative_regulation of Phosphorylation of Trh 1 0.01 0 0.39
58 INT183645 Ppp1r14b Positive_regulation of Macf1 1 0.00 1.23 0.38
59 INT183646 Negative_regulation of Ppp1r14b Positive_regulation of Macf1 1 0.00 1.29 0.38
60 INT116678 Binding of ARRB1 and Oxtr 1 0.13 0.15 0.38
61 INT335994 Timp1 Regulation of Col7a1 1 0.01 0.36 0.37
62 INT285465 IL7 Positive_regulation of TNF 1 0.04 0.67 0.35
63 INT179845 Il11 Positive_regulation of Negative_regulation of Timp1 1 0.14 0 0.35
64 INT105768 Binding of Nos1 and Nqo1 1 0.00 0.26 0.34
65 INT144448 Nqo1 Regulation of Nos1 1 0.11 0.09 0.34
66 INT144450 Regulation of Nqo1 Regulation of Nos1 1 0.11 0.1 0.34
67 INT24127 Cast Positive_regulation of Mme 1 0.15 0 0.33
68 INT235971 Positive_regulation of Binding of Nqo1 and NMO-IgG 1 0.00 1.86 0.32
69 INT243641 Twist1 Positive_regulation of Socs1 1 0.14 0.13 0.31
70 INT220521 Ugt1a6b Positive_regulation of Cdkn1b 1 0.01 2.38 0.31
71 INT174464 IL7 Positive_regulation of IL4 1 0.40 0.61 0.31
72 INT243634 Twist1 Regulation of Socs1 1 0.14 0.13 0.31
73 INT315394 IFNA1 Positive_regulation of Gene_expression of Socs1 1 0.01 0.41 0.31
74 INT196798 Trh Positive_regulation of Phosphorylation of Ppp1r1b 1 0.01 0 0.3
75 INT315398 IFNA1 Positive_regulation of Socs1 1 0.01 0.41 0.3
76 INT287747 Anxa1 Positive_regulation of Lpar1 1 0.04 0 0.29
77 INT319753 Mpo Positive_regulation of Timp1 1 0.14 2.13 0.29
78 INT287748 Positive_regulation of Anxa1 Positive_regulation of Lpar1 1 0.04 0 0.29
79 INT172977 Cdkn1a Negative_regulation of Positive_regulation of Inca1 1 0.00 1.39 0.27
80 INT337113 Ppp1r1b Negative_regulation of Phosphorylation of Cdk5 1 0.11 0.28 0.27
81 INT170560 Binding of Renbp and Narf 1 0.01 1.69 0.27
82 INT348924 Mmp1 Regulation of Gene_expression of Renbp 1 0.03 0.95 0.26
83 INT235959 Nqo1 Positive_regulation of Localization of Aqp4 1 0.02 1.39 0.26
84 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
85 INT206763 Binding of CSF2 and Nqo1 1 0.00 1.7 0.25
86 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
87 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
88 INT162931 TXNRD1 Negative_regulation of Phosphorylation of NQO1 1 0.13 0.5 0.23
89 INT235967 Binding of Ighm and Nqo1 1 0.00 1.45 0.23
90 INT245555 Runx1 Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
91 INT245565 Runx1 Negative_regulation of Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
92 INT276046 Negative_regulation of Prkaca Positive_regulation of Phosphorylation of Ppp1r1b 1 0.15 0.11 0.23
93 INT238802 Binding of Ager and Renbp 6 0.02 6.46 0.22
94 INT302978 Nqo1 Positive_regulation of Smpd2 1 0.01 1.1 0.22
95 INT174465 IL7 Positive_regulation of Gene_expression of TH1L 1 0.21 0.56 0.22
96 INT346409 Negative_regulation of Binding of mn and Tesc 1 0.00 0.29 0.22
97 INT346408 Binding of mn and Tesc 1 0.00 0.29 0.22
98 INT174466 Binding of IL7 and Positive_regulation of Gene_expression of TH1L 1 0.21 0.55 0.22
99 INT174462 IL7 Positive_regulation of TH1L 1 0.20 0.56 0.22
100 INT112912 Nts Positive_regulation of Phosphorylation of Arpp19 1 0.18 0 0.21
101 INT99733 Binding of F13A1 and Ppp1r1a 1 0.00 0.25 0.19
102 INT99735 Binding of PLG and Ppp1r1a 1 0.00 0.24 0.19
103 INT322543 Binding of FOXO3 and Cdkn1b 1 0.08 0.84 0.19
104 INT99731 Binding of Serpinf2 and Ppp1r1a 1 0.00 0.24 0.19
105 INT174472 IL4 Regulation of IL7 1 0.16 0.38 0.19
106 INT79511 Negative_regulation of NOS1 Regulation of Negative_regulation of Nqo1 1 0.05 0.08 0.19
107 INT339510 Tlr4 Positive_regulation of Socs1 1 0.06 0.1 0.18
108 INT112913 Nts Positive_regulation of Phosphorylation of Ppp1r1b 1 0.53 0 0.18
109 INT339252 Positive_regulation of GNRH1 Positive_regulation of Localization of SCG5 1 0.51 0 0.17
110 INT327790 Binding of Nqo1 and Alms1 1 0.00 1.1 0.17
111 INT226367 INCENP Negative_regulation of SOCS1 1 0.01 0.47 0.15
112 INT346414 Thy1 Positive_regulation of Binding of Tesc 1 0.00 0.16 0.15
113 INT339513 Binding of Socs1 and Eif2ak2 1 0.04 0.07 0.15
114 INT279102 Renbp Regulation of Hand1 1 0.02 0.27 0.14
115 INT246018 Timp1 Negative_regulation of Localization of Il1 1 0.01 1.05 0.14
116 INT246019 Timp1 Negative_regulation of Localization of TNF 1 0.23 1.05 0.14
117 INT346410 Binding of Caprin1 and Tesc 1 0.00 0.17 0.14
118 INT235961 Binding of Nqo1 and Aqp4 1 0.02 0.9 0.14
119 INT184122 Binding of Socs1 and Sh2 1 0.14 0 0.14
120 INT296233 Binding of Anxa1 and Trpa1 1 0.03 0.78 0.14
121 INT185455 MUC1 Negative_regulation of Timp1 1 0.06 0.84 0.13
122 INT226378 INCENP Positive_regulation of Transcription of SOCS1 1 0.01 0.41 0.13
123 INT305287 Renbp Regulation of FRTS 1 0.02 0.06 0.13
124 INT246016 Negative_regulation of Timp1 Negative_regulation of Gene_expression of Bcl2 1 0.03 1.07 0.13
125 INT185454 IGHG1 Negative_regulation of Timp1 1 0.04 0.85 0.13
126 INT246017 Timp1 Negative_regulation of Gene_expression of Bcl2 1 0.03 1.07 0.13
127 INT332581 Binding of Nqo1 and MRI1 1 0.01 1.68 0.12
128 INT289402 Negative_regulation of Cd55 Positive_regulation of Gene_expression of Ik 1 0.00 0.58 0.12
129 INT289407 Mthfd1 Negative_regulation of Cd55 1 0.01 0.6 0.12
130 INT289403 Cd55 Positive_regulation of Gene_expression of Ik 1 0.00 0.58 0.12
131 INT276069 Binding of Camk2a and Ppp1r1b 1 0.18 0 0.12
132 INT276057 Binding of Prkaca and Ppp1r1b 1 0.10 0 0.12
133 INT182368 IgG Regulation of Cast 1 0.01 0.99 0.11
134 INT174463 IL7 Regulation of Gene_expression of IFNA1 1 0.04 0.21 0.11
135 INT321863 Timp1 Negative_regulation of Gene_expression of Mcpt1 1 0.25 0.79 0.11
136 INT331562 Binding of Il7 and Trav6-3 1 0.05 0.49 0.11
137 INT185079 Bpifa2 Positive_regulation of Pln 1 0.10 0.33 0.11
138 INT299158 Binding of Lgals3 and Renbp 1 0.00 0.64 0.11
139 INT321861 Timp1 Negative_regulation of Mcpt1 1 0.25 0.79 0.11
140 INT321862 Timp1 Negative_regulation of Il6 1 0.12 0.79 0.11
141 INT203629 IL8 Negative_regulation of Timp1 1 0.05 0 0.1
142 INT15902 PKIA Negative_regulation of Positive_regulation of Prkaca 1 0.10 0 0.1
143 INT203626 IL6 Negative_regulation of Timp1 1 0.12 0 0.1
144 INT203623 Cxcl1 Negative_regulation of Timp1 1 0.01 0 0.1
145 INT339500 Negative_regulation of Socs1 Positive_regulation of Eif2ak2 1 0.05 0.31 0.09
146 INT276815 IL7 Positive_regulation of Gene_expression of Hgs 1 0.03 0.09 0.09
147 INT154914 UGT1A9 Regulation of IGHD6-6 1 0.05 0 0.09
148 INT335772 MIR155 Regulation of SOCS1 1 0.01 0.29 0.09
149 INT308652 Binding of Renbp and Nps 1 0.01 1.38 0.09
150 INT276033 Binding of Ppp1cc and Ppp1r1b 1 0.06 0 0.09
151 INT110855 Pkia Negative_regulation of Egf 1 0.15 1.2 0.08
152 INT188361 Il4 Positive_regulation of Socs1 1 0.14 0.15 0.08
153 INT220514 Ppara Positive_regulation of Gene_expression of Cdkn1b 1 0.08 1 0.08
154 INT184113 Socs1 Negative_regulation of Mthfd1 1 0.08 0.5 0.08
155 INT350708 Foxp3 Regulation of Socs1 1 0.08 0.21 0.07
156 INT184121 Socs1 Regulation of Mthfd1 1 0.05 0.44 0.07
157 INT273363 SOCS3 Regulation of Protein_catabolism of SOCS1 1 0.02 0 0.07
158 INT273364 SOCS3 Regulation of SOCS1 1 0.02 0 0.07
159 INT273371 JAK2 Regulation of Protein_catabolism of SOCS1 1 0.01 0 0.06
160 INT145626 Binding of PKLR and UGT1A1 1 0.02 0 0.06
161 INT242475 Ciapin1 Positive_regulation of Gene_expression of Anxa2 1 0.01 1.13 0.06
162 INT273365 JAK2 Regulation of SOCS1 1 0.01 0 0.06
163 INT145624 Binding of PKLR and UGT1A9 1 0.02 0 0.06
164 INT76862 Dynll1 Positive_regulation of Rb1 1 0.37 0.1 0.06
165 INT270664 Ensa Positive_regulation of Localization of Ins1 1 0.02 0.89 0.05
166 INT355586 Binding of LTBP1 and ANGPTL4 1 0.10 2.15 0.05
167 INT276337 Timp1 Positive_regulation of Il10 1 0.01 0.76 0.05
168 INT355583 Binding of EGFR and ANGPTL4 1 0.12 2.14 0.05
169 INT296236 Anxa1 Positive_regulation of Trpm8 1 0.04 0.09 0.05
170 INT184085 Socs1 Positive_regulation of Protein_catabolism of Insr 1 0.04 0.41 0.05
171 INT270659 Wnk1 Regulation of Napg 1 0.04 1.12 0.04
172 INT235969 Binding of Ighg1 and Nqo1 1 0.01 2.63 0.04
173 INT295263 Tlr4 Positive_regulation of Trib3 1 0.18 0.66 0.04
174 INT276381 Timp1 Positive_regulation of CD44 1 0.07 0.72 0.04
175 INT302981 Nqo1 Positive_regulation of Positive_regulation of Smpd2 1 0.00 0.45 0.04
176 INT296232 Anxa1 Regulation of Trpm8 1 0.03 0.54 0.04
177 INT346418 Sv2a Positive_regulation of Binding of Tesc 1 0.02 0.1 0.04
178 INT328301 GHRH Positive_regulation of SCG5 1 0.24 0.13 0.04
179 INT270661 Regulation of Wnk1 Regulation of Napg 1 0.04 1.13 0.04
180 INT276392 Timp1 Regulation of PTPN6 1 0.02 0.87 0.04
181 INT276385 Timp1 Regulation of CD44 1 0.04 0.87 0.04
182 INT302974 Nqo1 Positive_regulation of Jag2 1 0.00 0.45 0.04
183 INT346407 Negative_regulation of Binding of Tesc and Sv2a 1 0.02 0 0.03
184 INT235968 NMO-IgG Positive_regulation of Nqo1 1 0.00 2.11 0.03
185 INT172832 Binding of ROS1 and Renbp 1 0.00 0.83 0.03
186 INT220512 Cav1 Regulation of Positive_regulation of Cdkn1b 1 0.06 0.85 0.03
187 INT289250 Il6 Positive_regulation of Gene_expression of Timp1 1 0.11 0.64 0.03
188 INT239340 Cand1 Positive_regulation of RCT 1 0.11 1.26 0.03
189 INT278608 PPARA Positive_regulation of UGT1A9 1 0.25 0.29 0.03
190 INT342936 Renbp Positive_regulation of Ros1 1 0.02 1.56 0.03
191 INT276070 Negative_regulation of Pde1b Positive_regulation of Phosphorylation of Ppp1r1b 1 0.24 0 0.03
192 INT233276 Cdkn1a Regulation of Hoxa10 1 0.12 0.26 0
193 INT354097 Timp1 Negative_regulation of Localization of NFKB2 1 0.04 0.94 0
194 INT295045 Akt1 Positive_regulation of Protein_catabolism of Cdkn1b 1 0.09 2.06 0
195 INT47720 Gpr143 Regulation of Nqo1 1 0.01 0 0
196 INT322546 Negative_regulation of PTPN6 Positive_regulation of Gene_expression of Cdkn1b 1 0.03 0.07 0
197 INT277691 Cdkn1a Negative_regulation of Positive_regulation of Casp3 1 0.00 1.01 0
198 INT265848 Binding of HSD11B1 and Cand1 1 0.40 0.85 0
199 INT339499 Socs1 Regulation of Gene_expression of Eif2ak2 1 0.05 0.09 0
200 INT308643 Binding of Proc and Renbp 1 0.00 1.61 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of catalytic activity. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of catalytic activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99
2 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16
3 INT57257 Gene_expression of IL7 69 0.62 50.24 20.36
4 INT112908 Phosphorylation of Ppp1r1b 65 0.77 1.27 16.42
5 INT64563 Gene_expression of UGT1A1 27 0.75 3.31 13.43
6 INT10384 Positive_regulation of Nqo1 62 0.70 14.27 11.08
7 INT41627 Gene_expression of Nqo1 33 0.65 4.58 10.48
8 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84
9 INT62544 Gene_expression of Anxa1 21 0.47 13.56 9.71
10 INT111397 Localization of Timp1 17 0.70 11.67 8.76
11 INT140411 Gene_expression of Nqo1 45 0.60 62.35 8.7
12 INT96068 Positive_regulation of Timp1 30 0.58 23.94 8.17
13 INT57176 Positive_regulation of Dynll1 9 0.49 4.76 7.71
14 INT74099 Negative_regulation of Dynll1 8 0.56 3.43 7.25
15 INT77404 Gene_expression of ARRB1 19 0.62 1.53 7.22
16 INT140170 Binding of Nqo1 24 0.38 36.16 6.79
17 INT77408 Binding of ARRB1 11 0.36 0.31 6.51
18 INT53871 Gene_expression of Socs1 32 0.71 22.83 6.21
19 INT73382 Regulation of Nqo1 13 0.58 1.58 6.16
20 INT59384 Gene_expression of Il7 23 0.75 11.42 5.87
21 INT62270 Positive_regulation of Gene_expression of Cdkn1a 30 0.47 18.73 5.69
22 INT84704 Positive_regulation of Nqo1 18 0.70 18.64 5.65
23 INT60475 Gene_expression of Ugt1a1 17 0.77 4.26 5.62
24 INT138348 Positive_regulation of Phosphorylation of Ppp1r1b 16 0.56 1.4 4.63
25 INT151230 Positive_regulation of IL7 14 0.37 11.89 4.56
26 INT35599 Negative_regulation of Nqo1 25 0.54 4.6 4.42
27 INT74393 Gene_expression of Dynll1 8 0.65 2.64 4.39
28 INT20052 Negative_regulation of UGT1A1 12 0.58 4.51 4.29
29 INT113137 Positive_regulation of Ppp1r1b 14 0.65 0.89 4.21
30 INT102654 Positive_regulation of Pln 10 0.48 3.53 4.19
31 INT84703 Negative_regulation of Nqo1 8 0.38 7.1 4.05
32 INT196736 Gene_expression of Ppp1r1b 24 0.55 2.01 3.99
33 INT174477 Negative_regulation of IL7 11 0.47 10.35 3.69
34 INT39199 Positive_regulation of Ugt1a1 9 0.45 1.78 3.69
35 INT78514 Gene_expression of Cast 6 0.64 4.48 3.69
36 INT69943 Regulation of Gene_expression of Nqo1 3 0.26 0.98 3.56
37 INT169344 Positive_regulation of Gene_expression of Dynll1 3 0.49 2.34 3.48
38 INT93947 Regulation of Gene_expression of Timp1 5 0.25 5.04 3.42
39 INT65120 Regulation of Ugt1a1 3 0.45 1.07 3.29
40 INT62547 Positive_regulation of Gene_expression of Anxa1 5 0.42 4.52 3.27
41 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26
42 INT18744 Localization of Nqo1 7 0.69 1.06 3.19
43 INT112907 Regulation of Phosphorylation of Ppp1r1b 11 0.21 0.06 3.15
44 INT346398 Binding of Tesc 1 0.02 1.88 3.14
45 INT302808 Positive_regulation of Gene_expression of Il7 8 0.15 6.59 3.06
46 INT130603 Binding of Timp1 9 0.35 8.52 3.04
47 INT89229 Positive_regulation of Gene_expression of Nqo1 2 0.06 0.1 2.81
48 INT106833 Positive_regulation of ARRB1 4 0.39 1.21 2.71
49 INT104476 Protein_catabolism of Timp1 6 0.41 5.75 2.61
50 INT175685 Positive_regulation of Gene_expression of Timp1 11 0.57 8.18 2.58
51 INT165726 Positive_regulation of Anxa1 7 0.29 3.16 2.57
52 INT202051 Negative_regulation of PPP1R11 1 0.01 1.6 2.51
53 INT174481 Positive_regulation of Gene_expression of IL7 9 0.56 6.19 2.46
54 INT206760 Localization of Nqo1 8 0.09 15.76 2.4
55 INT88225 Transcription of Ugt1a1 5 0.61 1.51 2.4
56 INT174801 Positive_regulation of Il7 5 0.15 4.76 2.31
57 INT48750 Binding of Nqo1 5 0.29 0.1 2.31
58 INT184054 Negative_regulation of Gene_expression of Socs1 7 0.53 9.18 2.22
59 INT77396 Regulation of ARRB1 6 0.35 2.04 2.22
60 INT249563 Positive_regulation of Trib3 1 0.45 0.94 2.18
61 INT249555 Localization of Trib3 1 0.73 0.94 2.18
62 INT158459 Negative_regulation of Gene_expression of Timp1 8 0.40 4.21 2.16
63 INT57258 Regulation of Gene_expression of IL7 9 0.36 4.28 2.12
64 INT130754 Gene_expression of Cast 21 0.78 11.6 2.08
65 INT99410 Positive_regulation of UGT1A1 10 0.45 2.2 2.07
66 INT173509 Positive_regulation of Localization of Timp1 5 0.41 2.99 2.04
67 INT26415 Regulation of Phosphorylation of PKIA 1 0.01 0.06 2.04
68 INT26417 Phosphorylation of PKIA 1 0.02 0.06 2.04
69 INT79198 Positive_regulation of Positive_regulation of Dynll1 2 0.42 0.99 1.99
70 INT77410 Positive_regulation of Gene_expression of ARRB1 3 0.55 0.21 1.98
71 INT98782 Gene_expression of Cdkn1b 70 0.75 36.43 1.9
72 INT184042 Negative_regulation of Socs1 9 0.46 8.1 1.88
73 INT148944 Transcription of UGT1A1 3 0.59 0.07 1.84
74 INT122300 Negative_regulation of Positive_regulation of Nqo1 2 0.59 1.07 1.84
75 INT102825 Regulation of Timp1 10 0.38 5.49 1.79
76 INT8556 Positive_regulation of NQO1 12 0.70 5.11 1.78
77 INT196784 Regulation of Ppp1r1b 8 0.32 0.3 1.78
78 INT184068 Positive_regulation of Socs1 7 0.51 4.03 1.73
79 INT113539 Positive_regulation of Binding of ARRB1 1 0.02 0.11 1.72
80 INT47714 Regulation of Nqo1 12 0.24 11.12 1.71
81 INT174480 Binding of IL7 3 0.38 4.55 1.69
82 INT108252 Positive_regulation of Renbp 16 0.24 11.66 1.68
83 INT254250 Regulation of Socs1 5 0.06 3.04 1.66
84 INT181963 Regulation of IL7 7 0.49 3.56 1.61
85 INT167288 Regulation of Dynll1 3 0.45 1.22 1.56
86 INT137505 Positive_regulation of Cdkn1b 18 0.67 10.55 1.54
87 INT184052 Localization of Socs1 3 0.59 4.07 1.54
88 INT269828 Transcription of Timp1 3 0.38 5.2 1.53
89 INT181962 Negative_regulation of Gene_expression of IL7 7 0.47 4.51 1.5
90 INT44288 Binding of Ugt1a1 7 0.45 0.54 1.48
91 INT88224 Positive_regulation of Transcription of Ugt1a1 1 0.29 0.54 1.48
92 INT78889 Binding of UGT1A1 10 0.47 3.41 1.47
93 INT168863 Regulation of Wdtc1 3 0.08 1.88 1.45
94 INT197143 Positive_regulation of Renbp 15 0.33 9.41 1.31
95 INT77398 Negative_regulation of ARRB1 1 0.47 0 1.31
96 INT133255 Gene_expression of Anxa2 8 0.41 8.52 1.3
97 INT112904 Negative_regulation of Ppp1r1b 3 0.34 0.1 1.29
98 INT106830 Positive_regulation of Positive_regulation of ARRB1 1 0.16 0.13 1.28
99 INT78517 Regulation of Gene_expression of Cast 2 0.30 1.28 1.25
100 INT113136 Positive_regulation of Positive_regulation of Ppp1r1b 2 0.47 0 1.25
101 INT174482 Localization of IL7 5 0.64 2.84 1.23
102 INT106832 Localization of ARRB1 2 0.22 0.3 1.21
103 INT130755 Positive_regulation of Gene_expression of Cast 4 0.70 4.3 1.18
104 INT130437 Phosphorylation of Nqo1 3 0.25 0.97 1.14
105 INT108246 Regulation of Renbp 5 0.21 4.66 1.12
106 INT77411 Regulation of Gene_expression of ARRB1 3 0.36 0.61 1.12
107 INT128412 Positive_regulation of Cand1 5 0.67 3.58 1.1
108 INT205618 Gene_expression of Renbp 15 0.26 9.26 1.04
109 INT16024 Regulation of Cand1 5 0.60 2.74 1.04
110 INT106835 Positive_regulation of Localization of ARRB1 1 0.15 0.11 1.04
111 INT228871 Negative_regulation of Gene_expression of Anxa1 2 0.03 1.92 1.01
112 INT39198 Negative_regulation of Ugt1a1 7 0.52 1.35 0.92
113 INT316726 Regulation of Localization of Timp1 1 0.15 0.81 0.92
114 INT130438 Negative_regulation of Phosphorylation of Nqo1 1 0.01 0.47 0.91
115 INT60974 Gene_expression of Scgb1a1 34 0.71 7.48 0.9
116 INT137857 Positive_regulation of SCG5 3 0.49 1.01 0.88
117 INT99411 Positive_regulation of UGT1A9 2 0.39 0.65 0.88
118 INT112906 Negative_regulation of Phosphorylation of Ppp1r1b 5 0.55 0 0.86
119 INT184014 Binding of Socs1 2 0.34 0.97 0.84
120 INT295239 Negative_regulation of Anxa1 2 0.02 1.6 0.81
121 INT220498 Negative_regulation of Gene_expression of Cdkn1b 9 0.21 7.48 0.8
122 INT104475 Regulation of Protein_catabolism of Timp1 1 0.00 0.61 0.79
123 INT228844 Regulation of Gene_expression of Ppp1r1b 3 0.32 0.17 0.77
124 INT174803 Localization of Il7 2 0.11 1.67 0.77
125 INT59385 Binding of Il7 3 0.36 0.48 0.76
126 INT231620 Negative_regulation of Gene_expression of Il7 2 0.17 1.61 0.76
127 INT254249 Transcription of Socs1 2 0.29 1.6 0.74
128 INT174794 Negative_regulation of Localization of Il7 1 0.08 1.2 0.74
129 INT125270 Regulation of Binding of Nqo1 1 0.01 0.1 0.74
130 INT174804 Positive_regulation of Localization of Il7 1 0.07 1.18 0.73
131 INT49137 Negative_regulation of Positive_regulation of Nqo1 1 0.14 0.33 0.73
132 INT170546 Gene_expression of Renbp 15 0.32 14.33 0.72
133 INT116081 Negative_regulation of Binding of ARRB1 1 0.41 0 0.72
134 INT179481 Positive_regulation of Wdtc1 8 0.67 7.11 0.71
135 INT77406 Negative_regulation of Negative_regulation of ARRB1 1 0.47 0 0.71
136 INT100802 Binding of Ppp1r14a 1 0.08 0 0.7
137 INT149851 Transcription of Cast 1 0.33 0.35 0.7
138 INT327776 Negative_regulation of Gene_expression of Nqo1 2 0.02 2.39 0.69
139 INT77401 Regulation of Regulation of ARRB1 1 0.25 0 0.69
140 INT149848 Negative_regulation of Cast 1 0.21 0.38 0.68
141 INT149850 Regulation of Cast 1 0.13 0.38 0.67
142 INT190229 Gene_expression of Cd55 7 0.64 5 0.64
143 INT126732 Regulation of Cdkn1a 6 0.39 2.13 0.63
144 INT56207 Positive_regulation of Positive_regulation of Nqo1 7 0.47 1.08 0.62
145 INT184017 Positive_regulation of Gene_expression of Socs1 7 0.63 2.47 0.62
146 INT165542 Gene_expression of Socs1 2 0.32 1.31 0.62
147 INT159283 Negative_regulation of Transcription of Ugt1a1 1 0.38 0.15 0.62
148 INT99673 Localization of Cand1 1 0.73 0.15 0.62
149 INT134951 Gene_expression of NQO1 14 0.78 7.87 0.61
150 INT219793 Negative_regulation of Renbp 5 0.13 3.42 0.61
151 INT110819 Negative_regulation of Pln 4 0.42 1.57 0.6
152 INT130184 Positive_regulation of Regulation of Nqo1 1 0.14 0 0.6
153 INT174106 Binding of Renbp 18 0.24 15.82 0.58
154 INT122410 Transcription of Nqo1 4 0.68 1.42 0.58
155 INT235840 Negative_regulation of Gene_expression of Ppp1r1b 1 0.09 0.19 0.57
156 INT98786 Positive_regulation of Gene_expression of Cdkn1b 21 0.67 8.7 0.56
157 INT196774 Positive_regulation of Gene_expression of Ppp1r1b 4 0.31 0.29 0.56
158 INT36619 Gene_expression of SOCS1 9 0.44 4.83 0.55
159 INT205619 Regulation of Renbp 6 0.17 1.91 0.55
160 INT235515 Positive_regulation of Gene_expression of Renbp 5 0.24 5.19 0.54
161 INT196738 Binding of Ppp1r1b 3 0.26 0.27 0.53
162 INT137412 Negative_regulation of Cast 6 0.49 4.03 0.52
163 INT129635 Positive_regulation of SOCS1 3 0.49 0.92 0.49
164 INT163828 Localization of Cdkn1b 4 0.66 5.2 0.48
165 INT216519 Gene_expression of Wdtc1 4 0.65 4.02 0.47
166 INT180920 Positive_regulation of Positive_regulation of Timp1 2 0.38 1.59 0.46
167 INT302801 Positive_regulation of Positive_regulation of Il7 1 0.10 0.96 0.46
168 INT170554 Binding of Renbp 17 0.17 12.36 0.45
169 INT137504 Positive_regulation of Positive_regulation of Cdkn1b 2 0.45 1.71 0.45
170 INT129636 Transcription of SOCS1 2 0.52 1.29 0.45
171 INT163829 Positive_regulation of Localization of Cdkn1b 2 0.17 0.96 0.45
172 INT133783 Positive_regulation of Gene_expression of Ugt1a1 5 0.46 0.94 0.44
173 INT130436 Positive_regulation of Phosphorylation of Nqo1 1 0.01 0.2 0.44
174 INT110820 Positive_regulation of Negative_regulation of Pln 1 0.45 0 0.44
175 INT68850 Negative_regulation of NQO1 2 0.19 0.19 0.43
176 INT97606 Negative_regulation of Cdkn1a 7 0.43 4.24 0.42
177 INT197561 Localization of ANGPTL4 6 0.42 1.19 0.42
178 INT69808 Gene_expression of PPP1R11 1 0.02 0.32 0.42
179 INT230742 Negative_regulation of Il7 2 0.10 1.96 0.41
180 INT181987 Negative_regulation of Negative_regulation of Timp1 1 0.23 1.39 0.41
181 INT109486 Positive_regulation of Negative_regulation of Dynll1 1 0.48 0 0.41
182 INT237834 Regulation of Il7 4 0.26 0.95 0.4
183 INT131018 Phosphorylation of Cdkn1a 3 0.61 2.06 0.4
184 INT285545 Transcription of IL7 1 0.07 0.6 0.4
185 INT285550 Regulation of Transcription of IL7 1 0.04 0.61 0.4
186 INT185050 Localization of Pln 1 0.29 0.84 0.4
187 INT137410 Positive_regulation of Cast 4 0.70 4.37 0.39
188 INT183627 Negative_regulation of Ppp1r14b 2 0.02 1.98 0.38
189 INT183624 Binding of Ppp1r14b 1 0.02 1.06 0.38
190 INT167696 Positive_regulation of Gene_expression of NQO1 3 0.45 1.22 0.35
191 INT203309 Regulation of Anxa2 1 0.42 1.03 0.35
192 INT60969 Positive_regulation of Scgb1a1 4 0.56 2.6 0.34
193 INT60477 Gene_expression of UGT1A9 2 0.24 0 0.34
194 INT139941 Localization of Ugt1a1 2 0.70 0.21 0.33
195 INT19783 Localization of Wdtc1 2 0.13 1.89 0.33
196 INT68851 Localization of NQO1 2 0.62 0.05 0.33
197 INT131017 Positive_regulation of Positive_regulation of Cdkn1a 5 0.67 1.89 0.32
198 INT60973 Localization of Scgb1a1 5 0.73 1.42 0.32
199 INT315375 Positive_regulation of Gene_expression of Socs1 1 0.21 0.41 0.31
200 INT117968 Regulation of Anxa1 1 0.39 1.36 0.31
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