GO:0043087

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Name regulation of GTPase activity
Categary Process
Go Slim No
Go Link GO:0043087
Unique Molecular Interactions 57
Total Molecular Interactions 66
Total Single Events 451
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of GTPase activity. They are ordered first by their pain relevance and then by number of times they were reported for regulation of GTPase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT315284 PRKG1 Positive_regulation of Nos1 1 0.33 0.85 1.56
2 INT85783 PRKG1 Regulation of Prkcg 1 0.09 0.38 0.9
3 INT221257 Pde5a Positive_regulation of PRKG1 3 0.07 0.19 0.86
4 INT150965 NT5C2 Positive_regulation of PRKG1 1 0.04 0.07 0.62
5 INT296487 PRKG1 Regulation of Phosphorylation of Rbm39 1 0.00 0.27 0.47
6 INT257229 Binding of PRKG1 and Pde5a 1 0.01 0.17 0.41
7 INT85782 Rb1 Regulation of PRKG1 1 0.00 0.38 0.37
8 INT221259 Pde5a Positive_regulation of Localization of PRKG1 1 0.00 0.06 0.37
9 INT304536 Mknk1 Positive_regulation of PRKG1 1 0.03 0.53 0.3
10 INT109016 Negative_regulation of Prkg1 Negative_regulation of Positive_regulation of PRKG1 1 0.06 0.28 0.26
11 INT257231 PRKG1 Negative_regulation of Ltp 1 0.07 0.07 0.2
12 INT257233 PRKG1 Positive_regulation of Phosphorylation of Creb1 1 0.01 0.09 0.2
13 INT202297 Pde5a Positive_regulation of Prkg1 1 0.00 0.13 0.18
14 INT304537 Map2k1 Positive_regulation of PRKG1 1 0.01 0.66 0.16
15 INT304535 Mapk1 Positive_regulation of PRKG1 1 0.05 0.65 0.16
16 INT234801 RAB3GAP1 Regulation of RAB3A 1 0.08 1.64 0.15
17 INT177914 PRKG1 Positive_regulation of Phosphorylation of MAPK8 1 0.02 1.07 0.14
18 INT177911 PRKG1 Positive_regulation of MAPK8 1 0.02 1.07 0.14
19 INT148174 Camk2a Positive_regulation of Positive_regulation of PRKG1 1 0.04 0 0.14
20 INT134400 Positive_regulation of PRKG1 Positive_regulation of Phosphorylation of MAPK8 1 0.30 1.13 0.14
21 INT47351 Binding of Ralbp1 and Ccl4 1 0.11 0.17 0.14
22 INT177916 PRKG1 Positive_regulation of Positive_regulation of MAP3K1 1 0.05 1.07 0.14
23 INT47352 Positive_regulation of Binding of Ralbp1 and Ccl4 1 0.14 0.17 0.14
24 INT135941 Positive_regulation of PDE2A Positive_regulation of Gene_expression of PRKG1 1 0.13 0.8 0.13
25 INT269335 PRKG1 Positive_regulation of Gene_expression of PRKCA 1 0.14 0 0.12
26 INT135943 Positive_regulation of PRKG1 Regulation of PDE2A 1 0.08 0.73 0.1
27 INT98269 PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
28 INT269327 PRKG1 Regulation of Localization of TMPO 1 0.02 0 0.08
29 INT98270 Positive_regulation of PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
30 INT269331 PRKG1 Regulation of ZAK 1 0.03 0 0.07
31 INT269329 Regulation of PRKG1 Regulation of ZAK 1 0.03 0 0.07
32 INT325261 Ralbp1 Positive_regulation of Gene_expression of Il33 1 0.01 0 0.05
33 INT221251 PRKG1 Negative_regulation of Positive_regulation of Ptpn2 1 0.04 0.7 0.05
34 INT221253 PRKG1 Negative_regulation of Ros1 1 0.01 0.69 0.05
35 INT325586 Nppa Positive_regulation of Prkg1 1 0.28 0.16 0.03
36 INT287062 Gopc Positive_regulation of Positive_regulation of Vav1 1 0.18 0.15 0
37 INT316500 INO80B Positive_regulation of RALBP1 1 0.00 0.31 0
38 INT194716 Positive_regulation of Binding of VAV1 and ZAP70 1 0.04 0 0
39 INT199110 Vav1 Positive_regulation of Binding of Sergef 1 0.04 0.23 0
40 INT194711 LAT Positive_regulation of Binding of VAV1 1 0.03 0 0
41 INT294412 Binding of Vav2 and Vav3 1 0.41 0.65 0
42 INT228118 Binding of Fyn and Vav1 1 0.11 0.21 0
43 INT288826 Binding of Rac1 and Vav1 1 0.25 0.68 0
44 INT287061 Chrm2 Positive_regulation of Phosphorylation of Vav1 1 0.14 0.15 0
45 INT288827 Binding of Rasgrf2 and Vav1 1 0.40 0.37 0
46 INT194692 Binding of VAV1 and LAT 1 0.02 0 0
47 INT228115 Gene_expression of Chrm2 Positive_regulation of Phosphorylation of Vav1 1 0.16 0.26 0
48 INT277864 Binding of ERBB2 and Ralbp1 1 0.28 0.57 0
49 INT269588 PRKG1 Positive_regulation of Phosphorylation of TMPO 1 0.11 0 0
50 INT194687 Binding of VAV1 and ZAP70 1 0.03 0 0
51 INT287075 Positive_regulation of Vav1 Positive_regulation of Gene_expression of Prdm1 1 0.14 0.15 0
52 INT268052 Pde5a Positive_regulation of Positive_regulation of PRKG1 1 0.00 0 0
53 INT269550 TMPO Positive_regulation of Phosphorylation of PRKG1 1 0.11 0 0
54 INT194734 ZAP70 Positive_regulation of Binding of VAV1 1 0.05 0 0
55 INT353316 Prkg1 Positive_regulation of Phosphorylation of PRKG1 1 0.00 0.06 0
56 INT336468 Binding of CTS and ADAP1 1 0.02 0.42 0
57 INT269558 Gene_expression of PRKG1 Positive_regulation of Phosphorylation of TMPO 1 0.11 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of GTPase activity. They are ordered first by their pain relevance and then by number of times they were reported in regulation of GTPase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT81210 Positive_regulation of PRKG1 71 0.70 26.83 19.89
2 INT76434 Negative_regulation of PRKG1 25 0.58 10.36 10.81
3 INT89677 Gene_expression of PRKG1 38 0.78 13.98 8.56
4 INT116055 Phosphorylation of PRKG1 33 0.80 2.22 5.58
5 INT76433 Regulation of PRKG1 13 0.34 4.27 4.57
6 INT89678 Positive_regulation of Gene_expression of PRKG1 15 0.70 5.99 3.84
7 INT109015 Positive_regulation of Positive_regulation of PRKG1 5 0.38 2.04 1.87
8 INT116056 Positive_regulation of Phosphorylation of PRKG1 8 0.33 0.27 1.37
9 INT156993 Localization of PRKG1 6 0.35 1.06 1.34
10 INT105865 Regulation of Gene_expression of PRKG1 4 0.12 1.82 1.15
11 INT154197 Positive_regulation of Prkg1 2 0.44 1.32 1.12
12 INT196276 Regulation of Phosphorylation of PRKG1 6 0.27 0 1.06
13 INT149575 Gene_expression of Prkg1 8 0.58 1.87 0.85
14 INT105864 Binding of PRKG1 2 0.36 0.42 0.83
15 INT105866 Negative_regulation of Positive_regulation of PRKG1 3 0.12 0.98 0.64
16 INT269380 Negative_regulation of Gene_expression of PRKG1 3 0.19 1.3 0.56
17 INT221225 Negative_regulation of Negative_regulation of PRKG1 1 0.08 0 0.51
18 INT149578 Localization of Prkg1 1 0.56 0.6 0.41
19 INT221221 Positive_regulation of Localization of PRKG1 2 0.09 0.11 0.37
20 INT154353 Positive_regulation of Phosphorylation of Prkg1 1 0.34 0.66 0.37
21 INT154352 Phosphorylation of Prkg1 1 0.46 0.66 0.37
22 INT194779 Binding of VAV1 2 0.14 1.62 0.36
23 INT263961 Binding of Prkg1 1 0.31 1.31 0.27
24 INT105135 Positive_regulation of Ralbp1 1 0.60 1.49 0.26
25 INT105134 Regulation of Ralbp1 1 0.23 1.5 0.26
26 INT269368 Negative_regulation of Phosphorylation of PRKG1 3 0.20 0 0.25
27 INT304507 Regulation of Positive_regulation of PRKG1 1 0.03 0.47 0.23
28 INT263957 Positive_regulation of Binding of Prkg1 1 0.37 0.14 0.15
29 INT316515 Positive_regulation of RALBP1 28 0.25 10.37 0.14
30 INT188260 Gene_expression of Ralbp1 1 0.02 0.53 0.14
31 INT47350 Binding of Ralbp1 1 0.10 0.17 0.14
32 INT284593 Transcription of Prkg1 1 0.07 0 0.14
33 INT263960 Negative_regulation of Prkg1 1 0.32 0.44 0.12
34 INT316511 Gene_expression of RALBP1 5 0.28 5.24 0.1
35 INT105132 Localization of Ralbp1 2 0.60 0.52 0.09
36 INT105133 Positive_regulation of Localization of Ralbp1 1 0.40 0.47 0.09
37 INT199072 Negative_regulation of Vav1 2 0.58 9.64 0.07
38 INT270629 Gene_expression of Vav3 3 0.78 9.71 0.06
39 INT294404 Transcription of Vav3 1 0.53 0 0.06
40 INT225725 Phosphorylation of RAB3GAP1 1 0.04 0.33 0.06
41 INT225724 Positive_regulation of RAB3GAP1 1 0.03 0.34 0.06
42 INT184012 Protein_catabolism of Vav1 1 0.96 0.34 0.05
43 INT184064 Regulation of Protein_catabolism of Vav1 1 0.26 0.34 0.05
44 INT199080 Localization of Vav1 2 0.66 1.74 0.03
45 INT326159 Positive_regulation of Gene_expression of RALBP1 1 0.25 1.58 0.03
46 INT194792 Regulation of Phosphorylation of VAV1 1 0.09 0 0.03
47 INT199101 Positive_regulation of Localization of Vav1 1 0.18 0.34 0.03
48 INT194796 Phosphorylation of VAV1 1 0.17 0 0.03
49 INT228104 Gene_expression of Vav1 13 0.77 12.18 0
50 INT287041 Binding of Vav1 6 0.37 3.4 0
51 INT199095 Phosphorylation of Vav1 3 0.42 0.6 0
52 INT287052 Positive_regulation of Vav1 2 0.50 3.51 0
53 INT294407 Positive_regulation of Negative_regulation of Vav3 1 0.50 0.73 0
54 INT353315 Negative_regulation of Localization of PRKG1 1 0.03 0.1 0
55 INT336472 Gene_expression of ADAP1 1 0.03 0.08 0
56 INT336471 Binding of ADAP1 1 0.02 0.08 0
57 INT288812 Regulation of Gene_expression of Vav1 1 0.45 3.41 0
58 INT199088 Positive_regulation of Phosphorylation of Vav1 1 0.18 0.25 0
59 INT316514 Regulation of Positive_regulation of RALBP1 1 0.07 0.38 0
60 INT294409 Regulation of Vav3 1 0.45 1.42 0
61 INT294397 Regulation of Binding of Vav3 1 0.45 0.87 0
62 INT288819 Negative_regulation of Transcription of Vav1 1 0.42 1.23 0
63 INT288804 Transcription of Vav1 1 0.68 3.37 0
64 INT336475 Negative_regulation of ADAP1 1 0.02 0.1 0
65 INT263959 Negative_regulation of Positive_regulation of Prkg1 1 0.31 0.14 0
66 INT288803 Positive_regulation of Gene_expression of Vav1 1 0.50 1.05 0
67 INT294403 Localization of Vav3 1 0.80 0.96 0
68 INT316512 Negative_regulation of Gene_expression of RALBP1 1 0.07 0.23 0
69 INT268026 Regulation of Negative_regulation of PRKG1 1 0.04 0 0
70 INT336474 Positive_regulation of Negative_regulation of ADAP1 1 0.02 0.1 0
71 INT194795 Positive_regulation of Phosphorylation of VAV1 1 0.11 0 0
72 INT316509 Positive_regulation of Positive_regulation of RALBP1 1 0.08 0.65 0
73 INT294402 Binding of Vav3 1 0.48 2.43 0
74 INT288814 Regulation of Vav1 1 0.12 1.12 0
75 INT294399 Negative_regulation of Vav3 1 0.59 1.59 0
76 INT338250 Positive_regulation of VAV1 1 0.13 0.38 0
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