GO:0043120

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Name tumor necrosis factor binding
Categary Function
Go Slim No
Go Link GO:0043120
Unique Molecular Interactions 63
Total Molecular Interactions 93
Total Single Events 709
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for tumor necrosis factor binding. They are ordered first by their pain relevance and then by number of times they were reported for tumor necrosis factor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
2 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
3 INT155460 Tnfrsf1a Positive_regulation of Positive_regulation of Nfkb1 1 0.42 2.39 1.82
4 INT155459 Tnfrsf1a Positive_regulation of Nfkb1 1 0.42 2.45 1.63
5 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
6 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
7 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
8 INT277831 Binding of TNFRSF1A and NPEPPS 1 0.01 1.1 0.87
9 INT289658 Tnfrsf1a Positive_regulation of Mcpt1 1 0.02 0.76 0.81
10 INT308176 TNF Regulation of Tnfrsf1a 1 0.05 1.19 0.75
11 INT275285 Ros1 Positive_regulation of Tnfrsf1a 1 0.27 1.06 0.72
12 INT155457 Tnfrsf1a Positive_regulation of Mapk14 1 0.20 1.17 0.67
13 INT155458 Tnfrsf1a Regulation of Gene_expression of Il6 1 0.22 1.11 0.63
14 INT106074 IL1B Positive_regulation of Gene_expression of A2M 1 0.03 0.75 0.49
15 INT106072 NFKB1 Positive_regulation of Gene_expression of A2M 1 0.19 0.75 0.49
16 INT275286 Ros1 Regulation of Positive_regulation of Tnfrsf1a 1 0.16 0.55 0.49
17 INT252634 Binding of TNF and Tnfrsf1a 4 0.02 2.4 0.46
18 INT327995 Positive_regulation of TRPV1 Positive_regulation of Tnfrsf1a 1 0.16 0.63 0.46
19 INT289661 Tnfrsf1a Positive_regulation of TNF 1 0.01 1.2 0.37
20 INT227904 TNFRSF1A Regulation of TNF 1 0.01 0.41 0.36
21 INT77791 fut10 Regulation of Regulation of Tnfrsf1a 1 0.02 0.85 0.36
22 INT190683 Binding of A2M and INS 4 0.11 4.97 0.32
23 INT77792 fut10 Negative_regulation of Positive_regulation of Tnfrsf1a 1 0.04 0.82 0.32
24 INT275284 Tnfrsf1a Positive_regulation of Gene_expression of Trpv1 1 0.54 0.36 0.32
25 INT140474 Tnfrsf1a Positive_regulation of PECAM1 1 0.00 1.18 0.3
26 INT94849 A2M Negative_regulation of Gene_expression of COL7A1 1 0.01 0.27 0.28
27 INT158265 Olr1745 Negative_regulation of Gene_expression of Ltb 1 0.01 0.52 0.27
28 INT41950 Ptger1 Positive_regulation of Localization of A2m 1 0.19 0.46 0.24
29 INT41949 Ptger1 Positive_regulation of Gene_expression of A2m 1 0.19 0.46 0.24
30 INT277995 TNF Positive_regulation of Gene_expression of Tnfrsf1a 1 0.03 1.48 0.22
31 INT277996 TNF Positive_regulation of Tnfrsf1a 1 0.03 1.48 0.22
32 INT60523 Binding of IL1B and TNFRSF1A 1 0.25 1.73 0.21
33 INT139336 Il1b Regulation of Tnfrsf1a 1 0.27 1.3 0.14
34 INT139338 Cts8 Regulation of Tnfrsf1a 1 0.05 1.3 0.14
35 INT139346 Cts8 Regulation of Gene_expression of Tnfrsf1a 1 0.05 1.3 0.14
36 INT139347 Il1b Regulation of Gene_expression of Tnfrsf1a 1 0.27 1.3 0.14
37 INT94850 A2M Negative_regulation of Gene_expression of PIP 1 0.01 0.14 0.14
38 INT252631 Binding of Casp3 and Tnfrsf1a 1 0.10 0.69 0.13
39 INT141881 Binding of MECOM and Tnfrsf1a 1 0.00 1.17 0.13
40 INT235775 Binding of Tnfrsf1a and Tradd 3 0.31 3 0.12
41 INT352488 Binding of EPO and TNFRSF1A 1 0.14 0.18 0.12
42 INT289660 Tnfrsf1a Negative_regulation of Transcription of Flt4 1 0.03 0.62 0.12
43 INT289657 Tnfrsf1a Negative_regulation of Gene_expression of Flt4 1 0.03 0.63 0.12
44 INT251568 Tnfrsf1b Positive_regulation of Tnfrsf1a 1 0.31 0.37 0.11
45 INT220114 Tnfrsf1a Positive_regulation of Esr1 1 0.14 1.14 0.1
46 INT190684 Binding of A2M and IGF1 1 0.16 1.54 0.1
47 INT220116 Tnfrsf1a Negative_regulation of TNF 1 0.06 0.56 0.09
48 INT251583 Binding of TNF and Positive_regulation of Tnfrsf1a 1 0.46 0 0.06
49 INT252768 TNF Regulation of Tnfrsf1a 1 0.01 1.02 0.04
50 INT349287 A2m Negative_regulation of Prtn3 1 0.00 0.4 0.03
51 INT292560 Binding of TNFRSF1A and TRAF2 1 0.08 0.09 0
52 INT351952 Sag Positive_regulation of Gene_expression of Tnfrsf1a 1 0.17 1.11 0
53 INT186344 Binding of Tnfrsf1a and Tnfrsf1b 1 0.20 0.48 0
54 INT127731 Binding of A2m and Mif 1 0.19 0 0
55 INT347413 Tlr4 Regulation of Gene_expression of Tnfrsf1a 1 0.01 0.12 0
56 INT292566 Binding of TNFRSF1A and MADD 1 0.05 0.09 0
57 INT292562 Binding of TNFRSF1A and TRADD 1 0.11 0.09 0
58 INT292559 Binding of TNFRSF1A and FADD 1 0.05 0.09 0
59 INT292564 Binding of TNFRSF1A and RIPK1 1 0.06 0.09 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for tumor necrosis factor binding. They are ordered first by their pain relevance and then by number of times they were reported in tumor necrosis factor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT86062 Positive_regulation of Tnfrsf1a 51 0.69 40.69 26.2
2 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03
3 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09
4 INT12114 Positive_regulation of Tnfrsf1a 46 0.69 36.26 22.54
5 INT77790 Positive_regulation of Gene_expression of Tnfrsf1a 16 0.67 15.88 8.5
6 INT275265 Negative_regulation of Positive_regulation of Tnfrsf1a 1 0.56 4.41 6.35
7 INT275272 Positive_regulation of Positive_regulation of Tnfrsf1a 8 0.48 6.44 5.97
8 INT15132 Gene_expression of TNFRSF1A 33 0.75 20.09 5.93
9 INT94118 Localization of Tnfrsf1a 9 0.72 7.24 5.81
10 INT105538 Negative_regulation of Tnfrsf1a 16 0.56 12.51 5.61
11 INT111520 Regulation of Tnfrsf1a 10 0.61 7.25 5.41
12 INT93739 Positive_regulation of Gene_expression of Tnfrsf1a 11 0.66 11.17 4.44
13 INT118230 Binding of Tnfrsf1a 15 0.42 7.63 4.39
14 INT187836 Binding of Tnfrsf1a 19 0.46 18.08 4.33
15 INT41942 Gene_expression of A2m 9 0.36 9.98 3.96
16 INT77786 Negative_regulation of Tnfrsf1a 5 0.56 5.03 3.58
17 INT77788 Regulation of Tnfrsf1a 14 0.57 11.24 3.53
18 INT96700 Positive_regulation of Positive_regulation of Tnfrsf1a 6 0.69 3.93 3.42
19 INT52899 Positive_regulation of TNFRSF1A 16 0.46 19.04 3.34
20 INT10141 Gene_expression of A2M 11 0.35 9.37 2.75
21 INT699 Positive_regulation of A2M 16 0.66 10.49 2.5
22 INT275279 Positive_regulation of Localization of Tnfrsf1a 3 0.48 1.13 2.17
23 INT23352 Negative_regulation of A2M 10 0.33 8.35 2.16
24 INT183381 Transcription of Tnfrsf1a 3 0.46 2.08 1.83
25 INT148705 Binding of TNFRSF1A 8 0.38 5.19 1.81
26 INT41639 Positive_regulation of A2m 7 0.46 4.52 1.74
27 INT3249 Regulation of A2M 7 0.39 3.29 1.61
28 INT60528 Negative_regulation of TNFRSF1A 6 0.42 4.86 1.45
29 INT107924 Localization of Tnfrsf1a 5 0.70 3.86 1.37
30 INT77785 Negative_regulation of Gene_expression of Tnfrsf1a 4 0.56 3.1 1.35
31 INT251554 Negative_regulation of Gene_expression of Tnfrsf1a 2 0.41 1.8 1.32
32 INT41944 Positive_regulation of Gene_expression of A2m 2 0.23 2.56 1.29
33 INT77782 Negative_regulation of Positive_regulation of Tnfrsf1a 3 0.41 1.21 1.16
34 INT41947 Regulation of A2m 2 0.29 1.08 1.14
35 INT275264 Negative_regulation of Localization of Tnfrsf1a 1 0.41 0.6 1.13
36 INT265004 Positive_regulation of Binding of Tnfrsf1a 1 0.36 1.23 1.1
37 INT33475 Gene_expression of Ltb 4 0.58 2.45 1.09
38 INT86931 Gene_expression of A2m 3 0.16 4.81 1.04
39 INT275270 Regulation of Localization of Tnfrsf1a 1 0.43 0.47 1.04
40 INT122647 Transcription of Tnfrsf1a 5 0.60 2.63 1.02
41 INT139333 Regulation of Gene_expression of Tnfrsf1a 3 0.40 5.41 0.98
42 INT41946 Localization of A2m 1 0.38 1.81 0.89
43 INT275266 Regulation of Gene_expression of Tnfrsf1a 2 0.44 5.44 0.8
44 INT98131 Regulation of TNFRSF1A 5 0.31 5.28 0.76
45 INT41943 Positive_regulation of Positive_regulation of A2m 2 0.22 1.19 0.74
46 INT41945 Negative_regulation of A2m 2 0.27 0.35 0.68
47 INT189322 Binding of A2M 7 0.29 12.1 0.66
48 INT257406 Localization of TNFRSF1A 3 0.46 2.6 0.55
49 INT167366 Positive_regulation of A2m 1 0.02 0.43 0.49
50 INT275268 Positive_regulation of Regulation of Tnfrsf1a 1 0.48 0.54 0.48
51 INT158263 Negative_regulation of Gene_expression of Ltb 2 0.29 1.2 0.47
52 INT29293 Positive_regulation of Ltb 2 0.14 0.66 0.41
53 INT158947 Positive_regulation of Gene_expression of Ltb 1 0.47 1.38 0.41
54 INT253242 Positive_regulation of Transcription of Tnfrsf1a 2 0.44 0.77 0.38
55 INT288336 Positive_regulation of Gene_expression of A2m 1 0.12 1.73 0.37
56 INT77783 Regulation of Positive_regulation of Tnfrsf1a 1 0.44 0.85 0.36
57 INT48772 Localization of A2M 3 0.78 2.83 0.35
58 INT202106 Positive_regulation of Gene_expression of TNFRSF1A 3 0.22 1.17 0.31
59 INT46524 Negative_regulation of Gene_expression of A2M 2 0.02 1.45 0.23
60 INT41948 Negative_regulation of Localization of A2m 1 0.20 0.46 0.23
61 INT114896 Negative_regulation of Positive_regulation of TNFRSF1A 1 0.17 0.83 0.23
62 INT269999 Regulation of Gene_expression of TNFRSF1A 2 0.44 0.53 0.17
63 INT3248 Positive_regulation of Positive_regulation of A2M 1 0.46 0.25 0.17
64 INT23708 Regulation of Regulation of A2M 1 0.02 0.68 0.17
65 INT167367 Binding of A2m 1 0.01 0.13 0.15
66 INT340783 Transcription of TNFRSF1A 1 0.17 0.37 0.13
67 INT340784 Positive_regulation of Transcription of TNFRSF1A 1 0.17 0.37 0.13
68 INT251547 Positive_regulation of Binding of Tnfrsf1a 1 0.38 0.37 0.11
69 INT193490 Negative_regulation of Gene_expression of A2m 1 0.06 0.56 0.1
70 INT220109 Protein_catabolism of Tnfrsf1a 1 0.63 0.39 0.08
71 INT98128 Positive_regulation of Regulation of TNFRSF1A 2 0.30 1.95 0.07
72 INT220108 Positive_regulation of Negative_regulation of Tnfrsf1a 1 0.45 0.47 0.06
73 INT183380 Positive_regulation of Transcription of Tnfrsf1a 1 0.26 0.15 0.05
74 INT292575 Phosphorylation of TNFRSF1A 1 0.39 0.2 0.04
75 INT199219 Negative_regulation of Positive_regulation of A2M 1 0.29 1.94 0.03
76 INT292583 Negative_regulation of Binding of TNFRSF1A 1 0.21 0.15 0
77 INT292594 Negative_regulation of Gene_expression of TNFRSF1A 1 0.20 0.06 0
78 INT236257 Regulation of Gene_expression of A2m 1 0.14 0 0
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