GO:0043123

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Name positive regulation of I-kappaB kinase/NF-kappaB cascade
Categary Process
Go Slim No
Go Link GO:0043123
Unique Molecular Interactions 4221
Total Molecular Interactions 6015
Total Single Events 44330
Pain Genes Associated 167

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of I-kappaB kinase/NF-kappaB cascade. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of I-kappaB kinase/NF-kappaB cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
3 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
4 INT140935 Binding of Cd40lg and Cd40 1 0.30 6.34 5.61
5 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
6 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
7 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
8 INT351352 Binding of Trpv1 and Lpar1 1 0.21 5.86 4.62
9 INT51497 Cck Negative_regulation of Localization of Trim13 1 0.34 0 4.53
10 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
11 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
12 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
13 INT259209 Binding of Glul and Flna 1 0.03 0 4.2
14 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
15 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01
16 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
17 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
18 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
19 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
20 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
21 INT150889 Il1a Regulation of Il10 1 0.22 3.49 2.95
22 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
23 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
24 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
25 INT351349 Prkcg Positive_regulation of Binding of Lpar1 1 0.15 2 2.82
26 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
27 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
28 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
29 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
30 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
31 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
32 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
33 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
34 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
35 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
36 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
37 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
38 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 0.24 0.92 2.2
39 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
40 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
41 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
42 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
43 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
44 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
45 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
46 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
47 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
48 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
49 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
50 INT221181 Binding of GOPC and Flna 1 0.03 0.06 2.08
51 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
52 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
53 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
54 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
55 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
56 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
57 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
58 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
59 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
60 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
61 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 0.06 1.02 1.87
62 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
63 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
64 INT155460 Tnfrsf1a Positive_regulation of Positive_regulation of Nfkb1 1 0.42 2.39 1.82
65 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
66 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
67 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
68 INT119413 SEMA6A Positive_regulation of TNFRSF11A 1 0.10 2.48 1.7
69 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
70 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
71 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
72 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
73 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
74 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
75 INT155459 Tnfrsf1a Positive_regulation of Nfkb1 1 0.42 2.45 1.63
76 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
77 INT167202 TNF Regulation of Gene_expression of Ngf 1 0.10 1.47 1.6
78 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
79 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59
80 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
81 INT130839 Gfap Positive_regulation of S100B 1 0.51 1.9 1.56
82 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
83 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
84 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
85 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
86 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
87 INT167201 Gtf3a Regulation of TNF 1 0.01 1.39 1.52
88 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
89 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
90 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
91 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
92 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1 0.48 1.69 1.5
93 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
94 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
95 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
96 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
97 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42
98 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
99 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 0.03 0 1.39
100 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
101 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
102 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
103 INT259211 Binding of Ppp1r9b and Flna 1 0.06 0 1.33
104 INT264327 IL-17 Positive_regulation of Gene_expression of Tnfsf11 1 0.07 3.19 1.33
105 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
106 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
107 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
108 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
109 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
110 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
111 INT107858 PRSS1 Positive_regulation of F2RL1 6 0.12 4.23 1.29
112 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29
113 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28
114 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
115 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27
116 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
117 INT8409 IL1A Positive_regulation of Positive_regulation of Vip 1 0.01 0.63 1.27
118 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26
119 INT296796 Tbrs1 Positive_regulation of Gene_expression of TNF 1 0.00 1.58 1.26
120 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
121 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
122 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
123 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
124 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
125 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 0.02 0 1.23
126 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
127 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 0.32 2.09 1.22
128 INT70035 TNF Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
129 INT70039 IL1B Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
130 INT70032 TNF Regulation of PRF1 1 0.05 1.42 1.21
131 INT70040 TNF Regulation of Negative_regulation of IL10 1 0.09 1.42 1.21
132 INT70038 IL1B Regulation of PRF1 1 0.05 1.42 1.21
133 INT181490 Tryptase Positive_regulation of F2rl1 1 0.13 1.83 1.21
134 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
135 INT70031 IL1B Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
136 INT70030 IL1B Regulation of IL10 1 0.07 1.42 1.21
137 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
138 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2
139 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2
140 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
141 INT83428 Binding of ADIPOQ and FRTS 3 0.18 2.02 1.19
142 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
143 INT57824 Binding of Trim13 and Slc25a2 1 0.01 0.08 1.19
144 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18
145 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18
146 INT20929 Binding of Trim13 and Vas1 1 0.10 0 1.18
147 INT228680 Fkbp1a Negative_regulation of Trib3 1 0.01 0.56 1.18
148 INT150835 Gper Positive_regulation of Localization of Prkce 1 0.15 0.62 1.18
149 INT57823 Binding of Trim13 and Atxn2l 1 0.00 0.08 1.17
150 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
151 INT111221 MMEL1 Negative_regulation of HMOX1 1 0.01 1 1.16
152 INT353338 F2r Positive_regulation of Localization of Mif 1 0.68 1.25 1.16
153 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
154 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
155 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
156 INT94502 Il1b Positive_regulation of Gene_expression of Avp 1 0.28 1.97 1.15
157 INT94509 Il1b Positive_regulation of Gene_expression of AVP 1 0.36 1.96 1.15
158 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
159 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
160 INT76199 CASP1 Positive_regulation of CEL 1 0.06 0.32 1.14
161 INT66767 Il1b Positive_regulation of Pla2g10 1 0.05 0.47 1.13
162 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
163 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
164 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
165 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
166 INT66907 Il1b Positive_regulation of Localization of Oxt 2 0.78 0.18 1.12
167 INT147660 Positive_regulation of Prkce Positive_regulation of TRPV1 1 0.04 0.69 1.12
168 INT167428 Il1b Positive_regulation of Localization of Gpt 1 0.43 1.31 1.11
169 INT107264 Binding of TNF and NCR3 1 0.30 1.42 1.1
170 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
171 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1
172 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1
173 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
174 INT167426 Tlr4 Positive_regulation of Localization of Gpt 1 0.25 1.26 1.1
175 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
176 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
177 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
178 INT107562 Penk Positive_regulation of Localization of Il1b 1 0.20 0.09 1.09
179 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
180 INT130657 Negative_regulation of Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
181 INT74939 IL1B Positive_regulation of Gene_expression of HGF 1 0.58 0.72 1.09
182 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
183 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
184 INT76396 Il10 Negative_regulation of Il1b 2 0.65 1.89 1.08
185 INT107567 Hps4 Positive_regulation of Localization of Il1b 1 0.01 0.09 1.08
186 INT156238 Binding of F2rl1 and Tnfsf14 1 0.08 2.85 1.08
187 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
188 INT12684 Binding of Bcar3 and Trim13 1 0.03 0 1.08
189 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
190 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07
191 INT96905 Plxna3 Regulation of Regulation of Prkce 1 0.18 0.71 1.07
192 INT107564 Hps4 Regulation of Localization of Il1b 1 0.01 0.1 1.07
193 INT107560 Penk Regulation of Localization of Il1b 1 0.18 0.1 1.07
194 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
195 INT329959 Binding of TRAF1 and HEPACAM 1 0.03 2.25 1.06
196 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
197 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
198 INT131853 CD40 Negative_regulation of Gene_expression of CD40LG 1 0.09 1.54 1.05
199 INT8410 IL1A Positive_regulation of Vip 1 0.02 0.68 1.05
200 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of I-kappaB kinase/NF-kappaB cascade. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of I-kappaB kinase/NF-kappaB cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
3 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
4 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
5 INT6852 Localization of TNF 883 0.81 705.95 270.84
6 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
7 INT6481 Binding of TNF 624 0.48 510.2 214.82
8 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
9 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
10 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
11 INT9660 Regulation of TNF 363 0.62 312.94 139.99
12 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
13 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
14 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
15 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
16 INT10166 Localization of Tnf 237 0.81 153.95 88.64
17 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35
18 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
19 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
20 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
21 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38
22 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
23 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
24 INT6849 Localization of IL1B 229 0.81 112.56 69.63
25 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
26 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
27 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
28 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
29 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
30 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
31 INT221172 Binding of Flna 32 0.42 1.37 51.59
32 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
33 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
34 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
35 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
36 INT13354 Transcription of TNF 108 0.72 85.81 42.32
37 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
38 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48
39 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
40 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
41 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22
42 INT6484 Binding of IL1B 122 0.47 75.84 35.07
43 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
44 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66
45 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23
46 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17
47 INT35406 Localization of Tnf 94 0.81 64.63 31.65
48 INT9347 Localization of Il1b 58 0.81 26.13 31.53
49 INT56809 Binding of Tlr4 184 0.48 106.02 31.18
50 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18
51 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29
52 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19
53 INT94658 Positive_regulation of F2rl1 51 0.70 33.65 27.46
54 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
55 INT5966 Localization of Il1a 50 0.78 22.91 26.54
56 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4
57 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
58 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
59 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73
60 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24
61 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03
62 INT51029 Negative_regulation of Il1b 34 0.57 29.34 23.62
63 INT11746 Positive_regulation of Il1a 65 0.63 42.94 23.54
64 INT134651 Binding of TLR4 89 0.48 66.96 23.19
65 INT12114 Positive_regulation of Tnfrsf1a 46 0.69 36.26 22.54
66 INT48081 Localization of Il1b 46 0.80 21.59 22.4
67 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
68 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03
69 INT78057 Localization of Tlr4 140 0.77 67.75 21.72
70 INT116856 Gene_expression of TNFSF10 110 0.75 115.76 21.48
71 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37
72 INT90849 Gene_expression of F2rl1 55 0.78 31.31 20.65
73 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63
74 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34
75 INT53574 Regulation of Tnf 45 0.62 40.68 19.71
76 INT100732 Gene_expression of F2RL1 55 0.78 38.89 19.45
77 INT66751 Negative_regulation of Localization of Tnf 48 0.59 26 19.36
78 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19
79 INT66755 Transcription of Tnf 45 0.72 37.1 19.11
80 INT5967 Negative_regulation of Il1a 51 0.57 27.09 18.24
81 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86
82 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64
83 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33
84 INT36054 Transcription of IL1B 53 0.72 32.64 17.31
85 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15
86 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75
87 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58
88 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51
89 INT49986 Transcription of Tnf 25 0.72 18.3 16.22
90 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49
91 INT15102 Gene_expression of Trim13 18 0.67 0.43 15.49
92 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17
93 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6
94 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46
95 INT151120 Negative_regulation of Tlr4 18 0.59 21.09 14.46
96 INT108480 Gene_expression of CCL21 53 0.77 37.87 14.42
97 INT25266 Positive_regulation of Localization of IL1B 38 0.69 15.89 14.35
98 INT10173 Binding of Tnf 45 0.48 35.6 14.32
99 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16
100 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01
101 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74
102 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68
103 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63
104 INT142621 Positive_regulation of Gene_expression of CD36 38 0.70 15.18 13.4
105 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31
106 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9
107 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8
108 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71
109 INT58226 Negative_regulation of Gene_expression of Il1b 24 0.57 18.09 12.68
110 INT51028 Regulation of Il1b 28 0.60 21.15 12.47
111 INT60461 Positive_regulation of Gene_expression of Il1a 40 0.61 17.23 12.35
112 INT117502 Positive_regulation of Adipoq 70 0.63 40.43 12.03
113 INT149985 Gene_expression of Tlr9 32 0.75 29.83 11.86
114 INT221167 Gene_expression of Flna 11 0.60 0.69 11.81
115 INT19527 Negative_regulation of Gene_expression of Il1a 26 0.51 15.4 11.58
116 INT20603 Positive_regulation of TNFRSF10B 40 0.67 32.61 11.44
117 INT88650 Negative_regulation of Prkce 13 0.57 11.93 11.16
118 INT118742 Positive_regulation of Tlr4 32 0.69 27.55 11.09
119 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92
120 INT108479 Positive_regulation of CCL21 18 0.67 19.93 10.76
121 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75
122 INT60434 Negative_regulation of Positive_regulation of Tnf 20 0.46 10.01 10.64
123 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53
124 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51
125 INT50196 Transcription of Il1b 25 0.69 19.08 10.43
126 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34
127 INT91948 Positive_regulation of Prkce 16 0.64 11.36 10.32
128 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08
129 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78
130 INT68373 Negative_regulation of FLNA 59 0.57 60.46 9.55
131 INT48078 Regulation of Gene_expression of Il1b 15 0.62 14.78 9.53
132 INT72148 Positive_regulation of Prkce 17 0.68 5.06 9.44
133 INT71174 Gene_expression of CASP1 44 0.75 30.3 9.37
134 INT86851 Gene_expression of Faslg 45 0.75 24.42 9.21
135 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17
136 INT1567 Binding of TRIM13 10 0.47 0.24 9.16
137 INT182137 Gene_expression of TLR9 137 0.78 48.48 9.05
138 INT48860 Regulation of Localization of Tnf 25 0.61 20.68 8.78
139 INT15768 Gene_expression of Il1a 20 0.71 9.31 8.78
140 INT66213 Localization of RELA 63 0.78 14.71 8.77
141 INT21438 Binding of Trim13 10 0.47 0.26 8.76
142 INT146991 Positive_regulation of Gene_expression of Tlr4 21 0.69 20.76 8.69
143 INT53573 Negative_regulation of Localization of Tnf 19 0.59 11.57 8.54
144 INT70848 Gene_expression of Casp1 24 0.77 10.97 8.52
145 INT77790 Positive_regulation of Gene_expression of Tnfrsf1a 16 0.67 15.88 8.5
146 INT209866 Regulation of Gene_expression of CD36 27 0.60 10.04 8.42
147 INT15592 Positive_regulation of F2r 17 0.67 8.66 8.36
148 INT221173 Negative_regulation of Binding of Flna 4 0.33 0.13 8.25
149 INT82450 Negative_regulation of Hmox1 33 0.55 19.07 8.12
150 INT205203 Gene_expression of Lpar1 6 0.39 11.83 8.08
151 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89
152 INT66926 Transcription of Il1b 15 0.69 13.16 7.81
153 INT48077 Positive_regulation of Localization of Il1b 17 0.69 8.8 7.68
154 INT50195 Positive_regulation of Positive_regulation of Il1b 12 0.67 7.41 7.64
155 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58
156 INT19475 Positive_regulation of IL1A 20 0.67 17.99 7.57
157 INT95133 Gene_expression of FASLG 38 0.75 44.09 7.51
158 INT68299 Binding of Tnf 17 0.39 12.55 7.49
159 INT116717 Gene_expression of CCR7 37 0.76 34.1 7.48
160 INT38503 Positive_regulation of Ripk2 11 0.67 2.9 7.47
161 INT119729 Binding of Tnfsf11 31 0.35 24.02 7.45
162 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41
163 INT103791 Positive_regulation of Positive_regulation of F2rl1 10 0.50 11.24 7.41
164 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36
165 INT104207 Positive_regulation of Gene_expression of Tnfsf11 43 0.69 25.8 7.35
166 INT5308 Regulation of Il1a 17 0.44 10.8 7.31
167 INT11378 Negative_regulation of Positive_regulation of IL1B 23 0.59 10.28 7.26
168 INT66752 Positive_regulation of Transcription of Tnf 15 0.68 10.86 7.26
169 INT81293 Positive_regulation of Gene_expression of Hmox1 53 0.70 41.54 7.25
170 INT125136 Regulation of Adipoq 24 0.56 16.82 7.23
171 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16
172 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14
173 INT93003 Binding of CD40 28 0.47 20.25 7.13
174 INT12771 Positive_regulation of IKBKG 27 0.69 5.99 7.02
175 INT110104 Localization of Prkce 17 0.79 3.75 6.92
176 INT112986 Positive_regulation of S100b 19 0.70 17.61 6.86
177 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84
178 INT295467 Negative_regulation of Gene_expression of Tlr4 11 0.58 7.94 6.83
179 INT4431 Negative_regulation of Eda 10 0.46 3.53 6.81
180 INT117299 Localization of S100b 19 0.78 1.58 6.8
181 INT72532 Regulation of Gene_expression of Il1a 13 0.54 4.91 6.71
182 INT207892 Binding of Tlr9 35 0.46 26.66 6.61
183 INT48076 Negative_regulation of Localization of Il1b 10 0.59 3.46 6.58
184 INT87775 Phosphorylation of Gja1 13 0.82 2.75 6.56
185 INT81586 Negative_regulation of Casp1 11 0.57 6.55 6.45
186 INT48954 Positive_regulation of Localization of Il1b 13 0.53 8.16 6.44
187 INT67130 Negative_regulation of Localization of Il1b 7 0.57 1.36 6.42
188 INT171691 Protein_catabolism of Ecm1 31 0.20 11.57 6.38
189 INT205198 Positive_regulation of Lpar1 2 0.35 7.35 6.37
190 INT13406 Negative_regulation of CASP1 25 0.57 10.61 6.36
191 INT118516 Positive_regulation of Positive_regulation of F2RL1 7 0.49 4.63 6.33
192 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31
193 INT23034 Positive_regulation of Il1a 15 0.70 8.75 6.29
194 INT84716 Negative_regulation of Positive_regulation of Il1b 9 0.57 5.34 6.27
195 INT136555 Negative_regulation of Tnfsf11 31 0.55 22.23 6.23
196 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2
197 INT23465 Gene_expression of S100b 31 0.76 15.09 6.2
198 INT146043 Positive_regulation of Gene_expression of Adipoq 39 0.67 29.93 6.12
199 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06
200 INT97797 Localization of TLR4 18 0.77 13.78 6
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