GO:0043124

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Name negative regulation of I-kappaB kinase/NF-kappaB cascade
Categary Process
Go Slim No
Go Link GO:0043124
Unique Molecular Interactions 302
Total Molecular Interactions 412
Total Single Events 3145
Pain Genes Associated 21

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of I-kappaB kinase/NF-kappaB cascade. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of I-kappaB kinase/NF-kappaB cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81
2 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
3 INT83428 Binding of ADIPOQ and FRTS 3 0.18 2.02 1.19
4 INT139330 Binding of SGCG and Stat1 1 0.37 0.75 0.94
5 INT167947 Binding of STAT1 and Oprm1 1 0.00 0 0.86
6 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
7 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78
8 INT83424 Binding of CD40LG and ADIPOQ 2 0.13 1 0.59
9 INT83426 ADIPOQ Negative_regulation of Binding of CD40LG 2 0.21 1 0.59
10 INT184100 Il6 Positive_regulation of Stat1 1 0.16 0.68 0.58
11 INT54304 Il1rl1 Regulation of Regulation of Pdyn 1 0.04 0.23 0.54
12 INT164902 Binding of IL1RL1 and IL33 4 0.37 1.2 0.53
13 INT310531 IL6 Regulation of Regulation of ADIPOQ 1 0.19 0.73 0.52
14 INT121821 Binding of STAT1 and Olr1583 1 0.00 0.21 0.51
15 INT138927 Ifng Positive_regulation of Gene_expression of Stat1 1 0.29 0.7 0.49
16 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
17 INT83423 ADIPOQ Negative_regulation of Binding of IGHG3 1 0.02 0.31 0.42
18 INT108732 Gene_expression of Gstp1 Positive_regulation of Gene_expression of Mgst1 1 0.44 0.58 0.41
19 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4
20 INT296945 ADIPOQ Negative_regulation of TNF 1 0.03 1.13 0.4
21 INT223829 Binding of GSTM1 and GSTP1 2 0.41 2.78 0.39
22 INT180442 Acot1 Positive_regulation of Rhoa 1 0.08 1.03 0.38
23 INT240617 Binding of APOB and ADIPOQ 1 0.04 3.62 0.38
24 INT240616 Binding of SHBG and ADIPOQ 1 0.31 4.43 0.37
25 INT315400 IFNA1 Positive_regulation of Phosphorylation of Stat1 1 0.02 0.4 0.33
26 INT207184 Binding of Adipoq and Lep 1 0.25 2.45 0.33
27 INT184084 Jak2 Positive_regulation of Stat1 1 0.33 0.3 0.33
28 INT184110 Jak1 Positive_regulation of Stat1 1 0.32 0.3 0.33
29 INT263978 Binding of ADRB2 and TNFAIP3 1 0.01 0.5 0.32
30 INT315392 IFNA1 Positive_regulation of Stat1 1 0.02 0.4 0.3
31 INT226512 Il1rl1 Positive_regulation of Jun 1 0.12 0.34 0.29
32 INT226505 Il1rl1 Positive_regulation of Mapk8 1 0.04 0.4 0.29
33 INT226509 Il1rl1 Positive_regulation of Gene_expression of Mapk8 1 0.05 0.4 0.29
34 INT240626 Binding of ADIPOQ and Hdlcl1 1 0.02 3.27 0.28
35 INT332246 Ros1 Positive_regulation of Stat1 1 0.02 0.46 0.27
36 INT253563 Csnk2a2 Regulation of Phosphorylation of Stat1 1 0.16 0.58 0.24
37 INT140376 TGM1 Positive_regulation of Rhoa 1 0.01 0 0.24
38 INT334390 ADIPOQ Positive_regulation of Localization of INS 1 0.09 1.3 0.23
39 INT328621 Gene_expression of Il1rl1 Positive_regulation of Cfp 1 0.00 0.06 0.23
40 INT163760 Ifng Positive_regulation of Phosphorylation of Stat1 1 0.12 0.08 0.23
41 INT179492 Binding of Ins1 and Adipoq 1 0.16 1.16 0.23
42 INT138929 Ifng Positive_regulation of Stat1 1 0.29 0.28 0.23
43 INT138926 Regulation of Ifng Positive_regulation of Stat1 1 0.17 0.28 0.23
44 INT138931 Ifng Positive_regulation of Positive_regulation of Stat1 1 0.31 0.28 0.23
45 INT186351 Binding of Gast and Stat1 3 0.16 2.77 0.22
46 INT249760 Positive_regulation of Cnr1 Negative_regulation of Gene_expression of Adipoq 1 0.20 0.81 0.22
47 INT260397 Positive_regulation of Hmox1 Positive_regulation of Gene_expression of Adipoq 1 0.37 0.78 0.22
48 INT306178 Rhoa Positive_regulation of Rock2 2 0.40 1.04 0.21
49 INT94338 IFNG Positive_regulation of Phosphorylation of Stat1 1 0.01 0.26 0.21
50 INT94339 IFNG Positive_regulation of Localization of Stat1 1 0.01 0.26 0.21
51 INT181765 WISP3 Regulation of Gene_expression of RHOC 1 0.49 1.46 0.21
52 INT223828 Binding of GSTP1 and MAPK8 1 0.06 1.8 0.21
53 INT242996 Adipoq Negative_regulation of Transcription of Cd68 1 0.22 0.6 0.21
54 INT242994 Adipoq Negative_regulation of Spp1 1 0.19 0.59 0.21
55 INT332304 Binding of Il6 and Adipoq 1 0.03 0.4 0.2
56 INT145886 Binding of CXCL1 and Adipoq 1 0.00 0.77 0.2
57 INT352518 Binding of FAT1 and Adipoq 1 0.01 2.79 0.2
58 INT217665 ADIPOQ Positive_regulation of INS 2 0.06 1.8 0.19
59 INT180435 Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
60 INT260394 Positive_regulation of Hmox1 Positive_regulation of Adipoq 1 0.37 0.78 0.19
61 INT180444 Positive_regulation of Acot1 Positive_regulation of Rhoa 1 0.08 0.43 0.19
62 INT180437 Positive_regulation of Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
63 INT139015 STAT1 Negative_regulation of Gene_expression of PTGS2 1 0.01 0.36 0.19
64 INT332251 Il13 Positive_regulation of Stat1 1 0.14 1.4 0.18
65 INT334394 ADIPOQ Negative_regulation of Gene_expression of Tnf 1 0.37 1.06 0.18
66 INT207186 Binding of Adipoq and Bmi1 1 0.01 1.65 0.18
67 INT63443 Binding of Pomc and Il1rl1 1 0.04 0.06 0.18
68 INT164908 Binding of IL1RAP and IL1RL1 1 0.08 0.1 0.18
69 INT140095 Stat1 Positive_regulation of Positive_regulation of Ifng 1 0.52 0.42 0.18
70 INT228168 Adipoq Positive_regulation of Prkag1 2 0.05 1.08 0.17
71 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
72 INT314078 Peo1 Negative_regulation of Stat1 1 0.31 1.23 0.17
73 INT355566 IL1RL1 Positive_regulation of Gene_expression of NOS2 1 0.00 0.27 0.17
74 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
75 INT226527 Il1rl1 Positive_regulation of Gene_expression of IK 1 0.00 0.42 0.15
76 INT226507 Il1rl1 Positive_regulation of Gene_expression of Jun 1 0.13 0.2 0.15
77 INT343848 Positive_regulation of TLR4 Positive_regulation of STAT1 1 0.17 0.16 0.15
78 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
79 INT226518 Il1rl1 Positive_regulation of MAPK14 1 0.04 0.2 0.15
80 INT240622 Binding of ADIPOQ and Etv3 1 0.04 1.32 0.15
81 INT295273 STAT1 Regulation of Transcription of Hp 1 0.00 0.63 0.15
82 INT305371 Binding of IL1RL1 and MRI1 1 0.09 0.95 0.15
83 INT314069 Gopc Negative_regulation of Stat1 1 0.14 0.95 0.15
84 INT343835 TLR4 Positive_regulation of STAT1 1 0.17 0.11 0.15
85 INT226520 Il1rl1 Positive_regulation of Gene_expression of MAPK14 1 0.03 0.2 0.15
86 INT157275 Binding of PRKAA1 and Adipoq 1 0.01 1.13 0.15
87 INT295272 STAT1 Regulation of Hp 1 0.00 0.63 0.14
88 INT249598 Stat1 Positive_regulation of Gene_expression of Cd40 1 0.41 0.46 0.14
89 INT157273 Adipoq Positive_regulation of PRKAA1 1 0.03 1.16 0.14
90 INT332243 Pdgfa Positive_regulation of Stat1 1 0.06 0.52 0.14
91 INT226516 Il1rl1 Positive_regulation of Phosphorylation of Jun 1 0.02 0.19 0.14
92 INT343861 Binding of IFN1@ and STAT1 1 0.00 0.13 0.14
93 INT186372 Binding of Irf1 and Stat1 1 0.04 2.06 0.14
94 INT295271 STAT1 Regulation of Gbp2 1 0.00 0.63 0.14
95 INT180447 Binding of Rhoa and Car2 1 0.17 0.56 0.13
96 INT241454 Rgnef Positive_regulation of Positive_regulation of Rhoa 1 0.04 0.11 0.13
97 INT325272 Il1rl1 Positive_regulation of Gene_expression of TNF 1 0.02 0.41 0.12
98 INT270663 Adipoq Positive_regulation of Il6 1 0.02 1.05 0.12
99 INT325268 Il1rl1 Positive_regulation of Gene_expression of Spg21 1 0.05 0.41 0.12
100 INT179493 Adipoq Positive_regulation of Ins1 1 0.20 0.99 0.12
101 INT270669 Adipoq Positive_regulation of IL8 1 0.01 1.06 0.12
102 INT150532 LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
103 INT326387 Binding of PROC and Rhoa 1 0.00 0.59 0.12
104 INT150533 Positive_regulation of LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
105 INT241446 Rgnef Positive_regulation of Rhoa 1 0.04 0.1 0.12
106 INT270665 Adipoq Positive_regulation of Ccl2 1 0.07 1.06 0.12
107 INT164746 Binding of LEP and Adipoq 1 0.07 0.69 0.12
108 INT228175 RNU1-1 Regulation of Adipoq 1 0.11 0.78 0.12
109 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11
110 INT257467 Fat1 Regulation of Gene_expression of Adipoq 1 0.08 0.56 0.11
111 INT240624 Binding of ADIPOQ and Hdl1 1 0.02 0.85 0.1
112 INT223827 MAPK8 Positive_regulation of Gene_expression of GSTP1 1 0.12 0.88 0.1
113 INT262996 ADIPOQ Regulation of INS 1 0.13 1.25 0.1
114 INT310275 Negative_regulation of Binding of Adipoq and Ins1 1 0.19 1.14 0.09
115 INT180449 Rhoa Regulation of Positive_regulation of Car2 1 0.13 0 0.09
116 INT157276 PPARG Positive_regulation of Adipoq 1 0.29 1.09 0.09
117 INT208300 IGIP Positive_regulation of Stat1 1 0.07 0.42 0.09
118 INT25285 CBS Negative_regulation of Localization of IL1RL1 1 0.05 0 0.09
119 INT157274 Adipoq Positive_regulation of ADIPOR1 1 0.00 1.2 0.09
120 INT180443 Rhoa Regulation of Negative_regulation of Mlc1 1 0.04 0 0.09
121 INT315383 Adcyap1 Regulation of Stat1 1 0.10 0.07 0.09
122 INT204902 Negative_regulation of Tlr4 Positive_regulation of Stat1 1 0.23 0.09 0.09
123 INT204879 Tlr4 Positive_regulation of Stat1 1 0.25 0.09 0.09
124 INT310274 Binding of Adipoq and Ins1 1 0.21 1.14 0.09
125 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
126 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
127 INT314075 Peo1 Regulation of Positive_regulation of Stat1 1 0.37 0.43 0.08
128 INT226515 Binding of Il1rl1 and Il33 1 0.02 0.36 0.08
129 INT228174 RNU1-1 Positive_regulation of Gene_expression of Adipoq 1 0.12 0.55 0.08
130 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
131 INT271284 Binding of IFNA1 and Stat1 1 0.07 0.7 0.08
132 INT257466 Psd Negative_regulation of Gene_expression of Adipoq 1 0.22 0.66 0.08
133 INT267154 ADIPOQ Regulation of Positive_regulation of SUGT1 1 0.03 1.18 0.08
134 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
135 INT314064 Gopc Negative_regulation of Positive_regulation of Stat1 1 0.12 0.57 0.08
136 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
137 INT278164 GSTM1 Positive_regulation of Transcription of GSTP1 1 0.57 0.94 0.07
138 INT352517 Binding of INS and Adipoq 1 0.09 1.32 0.07
139 INT186369 Negative_regulation of Binding of Gast and Stat1 1 0.04 1.04 0.07
140 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
141 INT262997 Binding of HSD11B1 and ADIPOQ 1 0.54 2.82 0.07
142 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
143 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
144 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
145 INT260392 Hmox1 Positive_regulation of Adipoq 1 0.32 0.65 0.07
146 INT312645 Binding of DNAJA3 and Musk 1 0.08 0.96 0.07
147 INT303997 IL1RL1 Positive_regulation of Lep 1 0.01 0.2 0.07
148 INT204891 Tlr4 Negative_regulation of Stat1 1 0.10 0.09 0.07
149 INT336380 Gene_expression of Adipoq Positive_regulation of Ppara 1 0.06 1.77 0.07
150 INT186366 Binding of Stat1 and Stat6 1 0.12 1.04 0.07
151 INT140813 Binding of Retn and Adipoq 1 0.03 1.18 0.06
152 INT326377 Ezr Positive_regulation of Positive_regulation of Rhoa 1 0.05 0.16 0.06
153 INT326378 Binding of Rhoa and Ezr 1 0.04 0.17 0.06
154 INT223825 GSTP1 Negative_regulation of MAPK8 1 0.11 1.53 0.06
155 INT183863 RHOC Positive_regulation of Gene_expression of MAPK1 1 0.25 0.26 0.05
156 INT326384 Slc9a3r2 Positive_regulation of Positive_regulation of Rhoa 1 0.03 0.16 0.05
157 INT267157 LEP Positive_regulation of ADIPOQ 1 0.10 0.51 0.05
158 INT325256 Chchd8 Regulation of Il1rl1 1 0.00 0.33 0.05
159 INT183851 RHOC Positive_regulation of MAPK1 1 0.34 0.26 0.05
160 INT183859 RHOC Positive_regulation of IFI44 1 0.18 0.26 0.05
161 INT217666 ADIPOQ Regulation of Gene_expression of INS 1 0.03 1.99 0.05
162 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
163 INT228169 Gm2733 Regulation of Adipoq 1 0.00 0.51 0.05
164 INT279902 Binding of GCLM and CARD8 1 0.28 0.82 0.05
165 INT183850 RHOC Positive_regulation of Gene_expression of IFI44 1 0.13 0.26 0.05
166 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
167 INT228591 Adipoq Positive_regulation of Phosphorylation of Prkaa2 1 0.31 0.61 0.04
168 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
169 INT180438 Positive_regulation of Rhoa Positive_regulation of Car2 1 0.22 0.48 0.03
170 INT314067 Stat1 Regulation of Nos2 1 0.13 0.2 0.03
171 INT236590 Binding of Adipoq and Ncoa2 1 0.15 0.2 0.03
172 INT183858 Negative_regulation of RHOC Positive_regulation of MAPK1 1 0.26 0.17 0.03
173 INT243636 Stat1 Positive_regulation of Gene_expression of Twist1 1 0.46 0.05 0.03
174 INT236587 Binding of Adipoq and Ncoa1 1 0.17 0.2 0.03
175 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
176 INT314077 Peo1 Negative_regulation of Positive_regulation of Stat1 1 0.31 0.33 0.03
177 INT249597 Jak2 Positive_regulation of Phosphorylation of Stat1 1 0.20 0.13 0.03
178 INT314370 Adipoq Positive_regulation of Tnfrsf11a 1 0.04 1.26 0.03
179 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
180 INT314071 Stat1 Regulation of Cxcl10 1 0.26 0.2 0.03
181 INT241450 Binding of Rhoa and Dpysl3 1 0.02 0 0.03
182 INT236592 Positive_regulation of Binding of Adipoq and Ncoa2 1 0.19 0.2 0.03
183 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
184 INT288829 Binding of Rhoa and Rac1 2 0.21 1.88 0
185 INT326383 Binding of Rhoa and Gopc 2 0.04 0.89 0
186 INT180040 Binding of D7Cwr3P and Sirt1 1 0.00 0 0
187 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
188 INT280543 Binding of GAST and STAT1 1 0.05 0.58 0
189 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0
190 INT285996 Binding of ACAT1 and IL1RL1 1 0.00 0 0
191 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0
192 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
193 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0
194 INT227305 Zbp1 Regulation of Gene_expression of Adipoq 1 0.21 1.27 0
195 INT180446 Rhoa Regulation of Gene_expression of Car2 1 0.21 0.17 0
196 INT334472 Gopc Regulation of Positive_regulation of Rhoa 1 0.02 0.3 0
197 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
198 INT164907 IFNG Positive_regulation of Gene_expression of IL1RL1 1 0.31 0.11 0
199 INT312642 DNAJA3 Positive_regulation of Musk 1 0.08 0.37 0
200 INT204323 Binding of ADIPOQ and Negative_regulation of Gene_expression of ROS1 1 0.08 0.12 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of I-kappaB kinase/NF-kappaB cascade. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of I-kappaB kinase/NF-kappaB cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11854 Gene_expression of Il1rl1 57 0.77 30.19 38.25
2 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58
3 INT11855 Positive_regulation of Gene_expression of Il1rl1 19 0.69 12.22 14.57
4 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46
5 INT117502 Positive_regulation of Adipoq 70 0.63 40.43 12.03
6 INT146197 Positive_regulation of Rhoa 60 0.68 34.12 12.02
7 INT65638 Negative_regulation of Gene_expression of Il1rl1 12 0.58 7.86 11.7
8 INT125136 Regulation of Adipoq 24 0.56 16.82 7.23
9 INT138922 Positive_regulation of Stat1 57 0.69 28.35 7.2
10 INT87432 Regulation of Gene_expression of Il1rl1 6 0.58 4.5 6.62
11 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2
12 INT146043 Positive_regulation of Gene_expression of Adipoq 39 0.67 29.93 6.12
13 INT163756 Phosphorylation of Stat1 45 0.82 14.51 6.11
14 INT138915 Gene_expression of Stat1 144 0.77 69.53 5.85
15 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
16 INT118870 Positive_regulation of STAT1 36 0.67 26.18 5.46
17 INT117499 Negative_regulation of Adipoq 28 0.56 24.15 5.07
18 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
19 INT109861 Gene_expression of Rhoa 11 0.78 5.67 4.02
20 INT83431 Binding of ADIPOQ 35 0.48 33.63 3.83
21 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67
22 INT28021 Positive_regulation of Adipoq 42 0.67 30.79 3.58
23 INT15299 Gene_expression of IL1RL1 37 0.69 10.09 3.43
24 INT146194 Negative_regulation of Rhoa 21 0.42 11.05 3.22
25 INT184060 Negative_regulation of Stat1 28 0.58 17.44 3.19
26 INT117501 Positive_regulation of Gene_expression of Adipoq 24 0.63 12.99 3.1
27 INT146191 Gene_expression of Rhoa 32 0.67 17.63 2.92
28 INT94327 Phosphorylation of Stat1 9 0.80 2.06 2.8
29 INT119839 Gene_expression of STAT1 17 0.75 8.36 2.7
30 INT45014 Regulation of IL1RL1 12 0.14 1.87 2.67
31 INT204340 Localization of ADIPOQ 20 0.75 25.18 2.64
32 INT26974 Negative_regulation of Adipoq 27 0.52 26.01 2.59
33 INT111451 Regulation of ADIPOQ 24 0.56 18.81 2.47
34 INT140363 Negative_regulation of Rhoa 7 0.58 2.49 2.47
35 INT146196 Localization of Rhoa 6 0.78 4.68 2.3
36 INT131850 Gene_expression of RHOC 17 0.72 29.06 2.28
37 INT122561 Negative_regulation of Gene_expression of Adipoq 12 0.56 14.02 2.26
38 INT135451 Positive_regulation of Positive_regulation of Adipoq 3 0.40 2.06 2.24
39 INT52601 Positive_regulation of Il1rl1 12 0.66 1.34 2.22
40 INT146192 Positive_regulation of Positive_regulation of Rhoa 8 0.60 8.15 2.17
41 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
42 INT25286 Localization of IL1RL1 7 0.56 3.17 2.07
43 INT138029 Binding of Adipoq 10 0.40 6.81 2.04
44 INT134633 Localization of Adipoq 9 0.60 6.39 2.03
45 INT142461 Positive_regulation of Positive_regulation of Stat1 7 0.54 5.06 1.94
46 INT126626 Positive_regulation of Rhoa 14 0.69 4.43 1.87
47 INT146193 Negative_regulation of Positive_regulation of Rhoa 3 0.42 3 1.84
48 INT135077 Binding of GSTP1 11 0.48 7.03 1.8
49 INT119837 Positive_regulation of Gene_expression of STAT1 6 0.49 3.66 1.73
50 INT227273 Localization of Adipoq 22 0.72 18.04 1.72
51 INT138917 Positive_regulation of Gene_expression of Stat1 63 0.69 36.76 1.71
52 INT186309 Binding of Stat1 18 0.48 5.31 1.58
53 INT140089 Positive_regulation of Stat1 5 0.68 3.42 1.58
54 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
55 INT146190 Negative_regulation of Localization of Rhoa 4 0.42 1.64 1.5
56 INT186064 Phosphorylation of STAT1 19 0.59 7.14 1.48
57 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
58 INT188241 Negative_regulation of ADIPOQ 16 0.43 22.16 1.47
59 INT28681 Gene_expression of Il1rl1 4 0.55 3.04 1.46
60 INT139326 Gene_expression of Stat1 6 0.76 2.49 1.41
61 INT121820 Binding of STAT1 9 0.46 2.54 1.4
62 INT131848 Positive_regulation of Gene_expression of RHOC 9 0.64 15.43 1.36
63 INT136574 Regulation of TNFAIP3 2 0.11 1.33 1.3
64 INT111859 Regulation of Rhoa 3 0.61 0.23 1.22
65 INT227275 Negative_regulation of Gene_expression of Adipoq 19 0.53 19.51 1.15
66 INT121814 Regulation of STAT1 3 0.43 0.83 1.15
67 INT213277 Positive_regulation of Gene_expression of ADIPOQ 14 0.50 17.7 1.14
68 INT178262 Transcription of Stat1 4 0.59 4.73 1.12
69 INT28493 Positive_regulation of IL1RL1 10 0.47 3.44 1.11
70 INT139325 Positive_regulation of Gene_expression of Stat1 3 0.68 1.18 1.1
71 INT163755 Positive_regulation of Phosphorylation of Stat1 4 0.60 1.87 1.09
72 INT139324 Positive_regulation of Phosphorylation of Stat1 3 0.44 1 1.09
73 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
74 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
75 INT180423 Positive_regulation of Gene_expression of Rhoa 7 0.40 6.22 0.98
76 INT139019 Negative_regulation of STAT1 10 0.57 5.04 0.97
77 INT156976 Gene_expression of TNFAIP3 4 0.65 5.25 0.93
78 INT160140 Regulation of Binding of Adipoq 1 0.37 0.87 0.92
79 INT128424 Transcription of STAT1 5 0.37 3.28 0.9
80 INT199483 Transcription of Stat1 2 0.43 1.14 0.89
81 INT163758 Regulation of Stat1 17 0.54 5.23 0.87
82 INT7552 Negative_regulation of IL1RL1 12 0.42 1.68 0.87
83 INT63442 Localization of Il1rl1 2 0.12 0.05 0.87
84 INT227270 Regulation of Gene_expression of Adipoq 5 0.55 7.35 0.85
85 INT146195 Positive_regulation of Localization of Rhoa 4 0.45 2.67 0.84
86 INT347182 Negative_regulation of TNFAIP3 3 0.23 5.6 0.84
87 INT151927 Regulation of Gene_expression of Adipoq 3 0.43 3.32 0.81
88 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
89 INT231380 Negative_regulation of Phosphorylation of Rhoa 1 0.13 1.28 0.79
90 INT142013 Positive_regulation of Regulation of Adipoq 1 0.03 0.65 0.78
91 INT28020 Binding of Adipoq 10 0.36 11.49 0.77
92 INT112386 Positive_regulation of Gene_expression of IL1RL1 4 0.47 2.72 0.77
93 INT28682 Negative_regulation of Gene_expression of Il1rl1 2 0.42 0.31 0.75
94 INT174553 Localization of Stat1 17 0.80 6.62 0.73
95 INT231369 Phosphorylation of Rhoa 1 0.25 1.22 0.73
96 INT148756 Regulation of Adipoq 10 0.60 7.83 0.67
97 INT128422 Positive_regulation of Positive_regulation of STAT1 5 0.35 4.24 0.67
98 INT164916 Binding of IL1RL1 9 0.33 1.84 0.66
99 INT129006 Negative_regulation of Gstp1 1 0.34 1.85 0.65
100 INT264003 Positive_regulation of Transcription of TNFAIP3 1 0.38 1.01 0.65
101 INT178250 Positive_regulation of Transcription of Stat1 2 0.43 2.72 0.64
102 INT263996 Transcription of TNFAIP3 1 0.39 0.99 0.64
103 INT278714 Regulation of Phosphorylation of STAT1 1 0.21 0.81 0.62
104 INT118310 Negative_regulation of Positive_regulation of Adipoq 2 0.34 2.47 0.61
105 INT179488 Positive_regulation of Transcription of Adipoq 3 0.37 0.5 0.6
106 INT316940 Positive_regulation of Phosphorylation of Rhoa 1 0.41 0.41 0.58
107 INT316931 Phosphorylation of Rhoa 1 0.48 0.41 0.57
108 INT140368 Positive_regulation of Positive_regulation of Rhoa 3 0.69 0.2 0.56
109 INT106022 Negative_regulation of GSTP1 5 0.59 2.12 0.55
110 INT180420 Negative_regulation of Gene_expression of Rhoa 3 0.37 1.65 0.55
111 INT180422 Regulation of Gene_expression of Rhoa 2 0.39 0.6 0.55
112 INT120762 Regulation of GSTP1 2 0.45 3.66 0.54
113 INT232453 Negative_regulation of DNAJA3 1 0.41 0 0.54
114 INT82749 Negative_regulation of Gene_expression of IL1RL1 4 0.40 2 0.52
115 INT227272 Transcription of Adipoq 8 0.64 8.29 0.49
116 INT138919 Regulation of Gene_expression of Stat1 4 0.60 4.58 0.49
117 INT83430 Positive_regulation of Binding of ADIPOQ 2 0.21 0.85 0.49
118 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
119 INT95328 Gene_expression of Gstp1 11 0.61 8.59 0.48
120 INT94328 Localization of Stat1 4 0.31 0.86 0.48
121 INT138914 Regulation of Positive_regulation of Stat1 3 0.45 1.02 0.48
122 INT186279 Negative_regulation of Binding of Stat1 3 0.42 0.96 0.45
123 INT140373 Binding of Rhoa 3 0.48 0.28 0.45
124 INT83434 Negative_regulation of Binding of ADIPOQ 1 0.39 1.14 0.45
125 INT328807 Positive_regulation of Positive_regulation of Stat1 1 0.24 0.08 0.45
126 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
127 INT129429 Negative_regulation of Stat1 2 0.41 1.09 0.44
128 INT245262 Negative_regulation of Gene_expression of Stat1 9 0.42 2.87 0.42
129 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
130 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
131 INT131851 Positive_regulation of RHOC 3 0.57 9.44 0.41
132 INT308980 Positive_regulation of Negative_regulation of Adipoq 3 0.33 2.3 0.4
133 INT138910 Negative_regulation of Positive_regulation of Stat1 3 0.57 0.81 0.39
134 INT328813 Negative_regulation of Phosphorylation of Stat1 1 0.21 0 0.37
135 INT80742 Regulation of Il1rl1 1 0.08 0.09 0.37
136 INT325423 Localization of Gstp1 1 0.06 0.85 0.37
137 INT310250 Regulation of TLE1 1 0.00 0.68 0.37
138 INT325425 Positive_regulation of Localization of Gstp1 1 0.04 0.9 0.37
139 INT87406 Gene_expression of GSTP1 16 0.77 11.37 0.35
140 INT164919 Transcription of IL1RL1 2 0.64 2.74 0.35
141 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
142 INT131849 Negative_regulation of RHOC 4 0.54 6.46 0.34
143 INT144474 Protein_catabolism of Gstp1 1 0.06 0.57 0.33
144 INT179491 Transcription of Adipoq 4 0.51 0.98 0.32
145 INT199762 Positive_regulation of Gstp1 2 0.55 2.02 0.32
146 INT206142 Localization of STAT1 7 0.78 3.09 0.31
147 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
148 INT226389 Localization of Il1rl1 2 0.53 0.93 0.31
149 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
150 INT189833 Negative_regulation of Phosphorylation of Stat1 4 0.51 1.1 0.3
151 INT227268 Negative_regulation of Transcription of Adipoq 4 0.52 4.93 0.3
152 INT189834 Regulation of Phosphorylation of Stat1 3 0.36 0.72 0.3
153 INT121817 Positive_regulation of Binding of STAT1 2 0.67 0.49 0.3
154 INT122401 Binding of Stat1 1 0.07 0.81 0.28
155 INT319433 Positive_regulation of Localization of IL1RL1 1 0.35 1.39 0.26
156 INT140371 Positive_regulation of Negative_regulation of Rhoa 1 0.46 0 0.26
157 INT226397 Positive_regulation of Il1rl1 2 0.31 1.04 0.25
158 INT278169 Regulation of Regulation of GSTP1 1 0.45 1.1 0.25
159 INT109859 Localization of Rhoa 3 0.54 1.09 0.24
160 INT289343 Regulation of Gene_expression of Rhoa 1 0.13 0.28 0.23
161 INT140365 Negative_regulation of Protein_catabolism of Rhoa 1 0.43 0 0.23
162 INT140358 Negative_regulation of Positive_regulation of Rhoa 1 0.43 0 0.23
163 INT289342 Negative_regulation of Gene_expression of Rhoa 1 0.20 0.28 0.23
164 INT289353 Positive_regulation of Gene_expression of Rhoa 1 0.23 0.28 0.23
165 INT180415 Regulation of Rhoa 7 0.53 3.92 0.22
166 INT94329 Positive_regulation of Localization of Stat1 1 0.02 0.26 0.22
167 INT140359 Positive_regulation of Protein_catabolism of Rhoa 1 0.69 0 0.22
168 INT140369 Protein_catabolism of Rhoa 1 0.99 0 0.22
169 INT253941 Positive_regulation of Localization of Adipoq 5 0.24 2.59 0.21
170 INT314061 Regulation of Negative_regulation of Stat1 1 0.23 0.79 0.21
171 INT180418 Binding of Rhoa 16 0.32 7.05 0.2
172 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
173 INT120761 Positive_regulation of GSTP1 3 0.50 3.4 0.19
174 INT121819 Regulation of Binding of STAT1 1 0.59 0.05 0.19
175 INT150529 Positive_regulation of Negative_regulation of Adipoq 2 0.37 1.76 0.18
176 INT271262 Negative_regulation of Negative_regulation of Stat1 2 0.42 1.4 0.18
177 INT197872 Regulation of Regulation of Adipoq 3 0.35 1.11 0.17
178 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
179 INT188215 Negative_regulation of Phosphorylation of STAT1 2 0.31 0.48 0.17
180 INT140361 Regulation of Positive_regulation of Rhoa 1 0.45 0 0.17
181 INT325238 Negative_regulation of Il1rl1 1 0.27 0.55 0.17
182 INT28026 Positive_regulation of Binding of Adipoq 1 0.27 0 0.17
183 INT137455 Protein_catabolism of ADIPOQ 1 0.66 0.25 0.17
184 INT228162 Negative_regulation of Localization of Adipoq 1 0.38 1.29 0.17
185 INT308978 Negative_regulation of Regulation of Adipoq 1 0.28 0.92 0.17
186 INT263001 Regulation of Gene_expression of ADIPOQ 5 0.45 3.77 0.16
187 INT325252 Positive_regulation of Gene_expression of Il1rl1 1 0.36 0.43 0.15
188 INT163262 Transcription of ADIPOQ 5 0.52 2.81 0.14
189 INT231559 Negative_regulation of Gene_expression of STAT1 2 0.06 0.36 0.14
190 INT319410 Positive_regulation of Transcription of IL1RL1 1 0.48 1.49 0.14
191 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
192 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
193 INT278171 Positive_regulation of Transcription of GSTP1 1 0.50 1.86 0.13
194 INT116052 Phosphorylation of Il1rl1 1 0.05 0.1 0.13
195 INT262999 Negative_regulation of Gene_expression of ADIPOQ 7 0.43 9.52 0.12
196 INT131847 Negative_regulation of Gene_expression of RHOC 2 0.39 1.38 0.12
197 INT131852 Positive_regulation of Negative_regulation of RHOC 1 0.46 1.12 0.12
198 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
199 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
200 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
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