GO:0043161

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Name proteasomal ubiquitin-dependent protein catabolic process
Categary Process
Go Slim No
Go Link GO:0043161
Unique Molecular Interactions 160
Total Molecular Interactions 227
Total Single Events 1475
Pain Genes Associated 31

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for proteasomal ubiquitin-dependent protein catabolic process. They are ordered first by their pain relevance and then by number of times they were reported for proteasomal ubiquitin-dependent protein catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT51497 Cck Negative_regulation of Localization of Trim13 1 0.34 0 4.53
2 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
3 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
4 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
5 INT227493 Binding of TCEA1 and SIRT2 1 0.01 1.55 1.93
6 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
7 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
8 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
9 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
10 INT94367 Binding of ARRB1 and TP53INP2 1 0.25 0 1.3
11 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
12 INT57824 Binding of Trim13 and Slc25a2 1 0.01 0.08 1.19
13 INT20929 Binding of Trim13 and Vas1 1 0.10 0 1.18
14 INT57823 Binding of Trim13 and Atxn2l 1 0.00 0.08 1.17
15 INT59203 ecs Positive_regulation of Negative_regulation of Ube2d3 1 0.00 1.93 1.15
16 INT12684 Binding of Bcar3 and Trim13 1 0.03 0 1.08
17 INT146097 Positive_regulation of Binding of Rgs9 and Arrb2 1 0.28 0 1.04
18 INT146098 Binding of Rgs9 and Arrb2 1 0.19 0 1.03
19 INT143916 Arrb2 Regulation of Rbm39 1 0.04 0.18 1
20 INT244133 DDB1 Positive_regulation of Gene_expression of IL6 1 0.01 1.91 0.99
21 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98
22 INT111632 Arrb2 Negative_regulation of Regulation of Rbm39 1 0.03 0 0.96
23 INT81329 Binding of ARRB1 and OPRK1 1 0.05 0.1 0.93
24 INT323698 Gene_expression of MIR146A Regulation of FAF1 1 0.16 1.82 0.86
25 INT46540 TRIM13 Positive_regulation of GPANK1 1 0.05 0 0.83
26 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
27 INT77393 Binding of ARRB1 and OPRM1 1 0.15 0 0.82
28 INT139745 Positive_regulation of Binding of Oprm1 and Arrb2 1 0.28 0.14 0.81
29 INT85686 Binding of Arrb1 and Arrb2 1 0.14 0.09 0.79
30 INT94366 Binding of ARRB1 and OPRD1 1 0.11 0 0.67
31 INT59202 ecs Positive_regulation of Ube2d3 1 0.00 0.98 0.59
32 INT77394 Binding of ARRB1 and GIPC1 1 0.01 0 0.56
33 INT72387 Trim13 Regulation of Phosphorylation of Shc1 1 0.32 0.09 0.54
34 INT240192 RBX1 Negative_regulation of BDNF 1 0.08 0.13 0.52
35 INT81330 ARRB1 Regulation of OPRK1 1 0.04 0.09 0.47
36 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
37 INT227495 Regulation of Binding of TCEA1 and SIRT2 1 0.01 0.45 0.45
38 INT167619 Protein_catabolism of Ppp2cb Positive_regulation of App 1 0.00 0.88 0.44
39 INT240193 RBX1 Positive_regulation of Gene_expression of BDNF 1 0.10 0 0.43
40 INT275849 PES1 Positive_regulation of Gene_expression of TNFAIP1 1 0.01 1.28 0.42
41 INT116678 Binding of ARRB1 and Oxtr 1 0.13 0.15 0.38
42 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
43 INT143914 Binding of Rbm39 and Arrb2 1 0.03 0.07 0.37
44 INT107726 BIRC2 Regulation of ASIP 1 0.03 0.24 0.35
45 INT170719 Binding of Grm5 and Siah1a 1 0.01 1.1 0.28
46 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
47 INT224135 Binding of ARRB2 and Adora2b 1 0.14 0.07 0.23
48 INT323699 MIR146A Regulation of Gene_expression of FAF1 1 0.22 0.93 0.23
49 INT168828 Binding of DDB1 and UBR1 1 0.00 0.67 0.19
50 INT170721 Siah1a Regulation of Negative_regulation of Grm2 1 0.22 0 0.18
51 INT323711 FAF1 Regulation of MIR146A 1 0.10 0.87 0.18
52 INT334263 Rnf216 Positive_regulation of Protein_catabolism of Tlr4 1 0.00 0.18 0.18
53 INT323706 Binding of FAF1 and MIR146A 1 0.13 0.87 0.18
54 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
55 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
56 INT224136 ARRB2 Positive_regulation of Adora2b 1 0.19 0 0.16
57 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
58 INT170724 Binding of Grm8 and Siah1a 1 0.19 0.11 0.15
59 INT224132 ARRB2 Negative_regulation of Positive_regulation of Adora2b 1 0.14 0.28 0.15
60 INT226204 Nfkb1 Positive_regulation of Gene_expression of Trim63 1 0.04 0.65 0.14
61 INT117913 CREM Positive_regulation of Negative_regulation of BIRC2 1 0.15 0.81 0.14
62 INT226208 Nfkb1 Positive_regulation of Protein_catabolism of Trim63 1 0.04 0.66 0.14
63 INT209645 AR Regulation of STUB1 1 0.04 0.93 0.13
64 INT324831 Binding of TRIM63 and Ticam1 1 0.01 0.09 0.12
65 INT117911 MAPK1 Regulation of Positive_regulation of BIRC2 1 0.04 0.9 0.12
66 INT231118 Tlr4 Positive_regulation of Gene_expression of Trim63 1 0.20 0.67 0.11
67 INT168829 Binding of DDB1 and TRPC4AP 1 0.02 0.34 0.1
68 INT323700 MIR146A Regulation of FAF1 1 0.22 0.69 0.09
69 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
70 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
71 INT190529 IFNA1 Positive_regulation of Transcription of TRIM63 1 0.00 0.39 0.08
72 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
73 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
74 INT243309 TNFAIP1 Positive_regulation of Localization of TNF 1 0.07 0.71 0.08
75 INT243313 TNFAIP1 Positive_regulation of TNF 1 0.31 0.71 0.08
76 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
77 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
78 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
79 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
80 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
81 INT170722 Siah1a Regulation of Gene_expression of Grm8 1 0.24 0 0.07
82 INT298258 Binding of Runx3 and Stub1 1 0.11 0.18 0.06
83 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
84 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
85 INT274715 TBL1XR1 Positive_regulation of TIMP1 1 0.00 0.26 0.04
86 INT213815 Binding of Tfeb and Stub1 1 0.13 0.09 0.04
87 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
88 INT244132 DDB1 Regulation of Transcription of NOD1 1 0.01 0.09 0.03
89 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
90 INT184134 Binding of Cish and Rbx1 1 0.10 0 0.03
91 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
92 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
93 INT180040 Binding of D7Cwr3P and Sirt1 1 0.00 0 0
94 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
95 INT281609 Foxo3 Positive_regulation of Transcription of Trim63 1 0.29 0 0
96 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0
97 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
98 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0
99 INT313117 Binding of Stub1 and Carf 1 0.10 0 0
100 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
101 INT170723 Binding of Calm2 and Siah1a 1 0.24 0 0
102 INT289534 Sirt1 Regulation of Regulation of Pomc 1 0.04 0.15 0
103 INT170718 Siah1a Regulation of Grm8 1 0.24 0 0
104 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0
105 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
106 INT289518 Arc Regulation of Sirt1 1 0.10 0.56 0
107 INT274716 TBL1XR1 Positive_regulation of Gene_expression of MMP1 1 0.02 0.45 0
108 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
109 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
110 INT305986 Binding of Nfe2l2 and Cul3 1 0.39 0.44 0
111 INT289517 Sirt1 Regulation of Prkag1 1 0.02 0.08 0
112 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
113 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
114 INT283062 ERCC8 Positive_regulation of CFH 1 0.02 1.88 0
115 INT348537 TNF Positive_regulation of Gene_expression of BIRC2 1 0.03 0.23 0
116 INT243635 Positive_regulation of Binding of Nfatc2 and Stub1 1 0.09 0 0
117 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
118 INT289598 Binding of Sirt1 and Sirt1 1 0.41 1.15 0
119 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0
120 INT289519 Sirt1 Regulation of Rps6kb1 1 0.25 0.13 0
121 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0
122 INT289523 Binding of Foxo1 and Positive_regulation of Sirt1 1 0.36 0.13 0
123 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
124 INT314132 Sirt1 Positive_regulation of Ppargc1a 1 0.50 2.3 0
125 INT299451 Foxl2 Negative_regulation of Gene_expression of Sirt1 1 0.25 0.32 0
126 INT289531 Acsm3 Positive_regulation of Sirt1 1 0.01 0.27 0
127 INT303160 Binding of Trim3 and Trim9 1 0.21 0 0
128 INT243628 Binding of Nfatc2 and Stub1 1 0.06 0 0
129 INT283061 Binding of ERCC8 and LDLR 1 0.00 0.44 0
130 INT323708 Binding of CASP8 and FAF1 1 0.07 0.73 0
131 INT281608 Foxo4 Positive_regulation of Transcription of Trim63 1 0.27 0 0
132 INT323705 Binding of FAS and FAF1 1 0.42 1.46 0
133 INT286773 Binding of Tusc2 and TRIM63 1 0.02 0.34 0
134 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
135 INT217315 Binding of UBE2I and ERVW-1 1 0.01 1.56 0
136 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
137 INT233117 Binding of SIRT2 and PAMR1 1 0.00 0 0
138 INT233118 Binding of SIRT2 and AICDA 1 0.00 0.21 0
139 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0
140 INT289535 Negative_regulation of Sirt1 Negative_regulation of Binding of Foxo1 1 0.29 0.14 0
141 INT289529 Lep Regulation of Sirt1 1 0.28 0.19 0
142 INT281607 Foxo1 Positive_regulation of Transcription of Trim63 1 0.27 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for proteasomal ubiquitin-dependent protein catabolic process. They are ordered first by their pain relevance and then by number of times they were reported in proteasomal ubiquitin-dependent protein catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15102 Gene_expression of Trim13 18 0.67 0.43 15.49
2 INT94981 Gene_expression of Arrb2 12 0.70 2.11 11.75
3 INT1567 Binding of TRIM13 10 0.47 0.24 9.16
4 INT21438 Binding of Trim13 10 0.47 0.26 8.76
5 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36
6 INT77404 Gene_expression of ARRB1 19 0.62 1.53 7.22
7 INT100079 Positive_regulation of Gene_expression of Arrb2 7 0.63 2.26 6.77
8 INT77408 Binding of ARRB1 11 0.36 0.31 6.51
9 INT94979 Regulation of Arrb2 6 0.54 0.51 6.45
10 INT80447 Negative_regulation of ARRB2 5 0.39 3.12 6.3
11 INT94986 Positive_regulation of Arrb2 5 0.61 1.3 6.24
12 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
13 INT85685 Gene_expression of Arrb2 5 0.74 0.66 5.13
14 INT85681 Negative_regulation of Arrb2 5 0.47 0.79 4.71
15 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
16 INT108935 Transcription of Arrb2 5 0.59 0.5 4.38
17 INT51494 Localization of Trim13 1 0.60 0 4.36
18 INT92797 Regulation of Arrb2 4 0.44 0.81 4.28
19 INT94985 Regulation of Gene_expression of Arrb2 2 0.40 0.43 4.2
20 INT2677 Regulation of Trim13 3 0.44 0.5 3.91
21 INT85679 Binding of Arrb2 4 0.39 0.79 3.82
22 INT51495 Positive_regulation of Trim13 3 0.41 0.08 3.81
23 INT94983 Negative_regulation of Arrb2 2 0.52 0.26 3.47
24 INT24160 Gene_expression of TRIM13 7 0.65 1.42 3.46
25 INT85682 Positive_regulation of Arrb2 4 0.46 0.22 3.05
26 INT80880 Gene_expression of ARRB2 4 0.65 3.51 2.71
27 INT106833 Positive_regulation of ARRB1 4 0.39 1.21 2.71
28 INT32923 Negative_regulation of Binding of TRIM13 2 0.57 0 2.38
29 INT170712 Gene_expression of Siah1a 1 0.77 2.33 2.33
30 INT108937 Negative_regulation of Transcription of Arrb2 1 0.38 0.31 2.31
31 INT77396 Regulation of ARRB1 6 0.35 2.04 2.22
32 INT30385 Protein_catabolism of Trim13 2 0.97 0 2.22
33 INT51496 Negative_regulation of Localization of Trim13 1 0.32 0 2.18
34 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
35 INT108939 Regulation of Transcription of Arrb2 1 0.24 0.19 2.1
36 INT77410 Positive_regulation of Gene_expression of ARRB1 3 0.55 0.21 1.98
37 INT275860 Negative_regulation of Localization of TNFAIP1 1 0.03 4.41 1.91
38 INT3911 Gene_expression of TNFAIP1 29 0.65 21.68 1.85
39 INT180134 Gene_expression of SIRT2 70 0.11 6.95 1.84
40 INT80885 Positive_regulation of Gene_expression of ARRB2 3 0.49 1.36 1.82
41 INT45064 Protein_catabolism of TRIM13 6 0.86 0 1.8
42 INT113539 Positive_regulation of Binding of ARRB1 1 0.02 0.11 1.72
43 INT125844 Positive_regulation of Gene_expression of Arrb2 2 0.48 0.45 1.66
44 INT41820 Positive_regulation of TRIM13 3 0.49 0.46 1.65
45 INT117915 Gene_expression of BIRC2 8 0.63 6.74 1.59
46 INT66942 Negative_regulation of Protein_catabolism of Trim13 1 0.50 0 1.58
47 INT72377 Phosphorylation of Trim13 1 0.79 0.27 1.57
48 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
49 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
50 INT158184 Localization of ARRB2 2 0.52 1.3 1.47
51 INT108936 Positive_regulation of Positive_regulation of Arrb2 1 0.41 0.25 1.4
52 INT243339 Localization of TNFAIP1 4 0.41 3.7 1.39
53 INT100275 Gene_expression of TBL1XR1 19 0.25 6.99 1.33
54 INT158183 Positive_regulation of Negative_regulation of ARRB2 1 0.35 1.13 1.33
55 INT77398 Negative_regulation of ARRB1 1 0.47 0 1.31
56 INT106830 Positive_regulation of Positive_regulation of ARRB1 1 0.16 0.13 1.28
57 INT59200 Negative_regulation of Ube2d3 3 0.13 2.37 1.23
58 INT106832 Localization of ARRB1 2 0.22 0.3 1.21
59 INT116537 Binding of ARRB2 1 0.34 0.3 1.19
60 INT302068 Phosphorylation of Arrb2 1 0.01 0.27 1.19
61 INT77411 Regulation of Gene_expression of ARRB1 3 0.36 0.61 1.12
62 INT60135 Negative_regulation of Protein_catabolism of TRIM13 1 0.30 0 1.1
63 INT46734 Positive_regulation of Stub1 6 0.16 1.44 1.09
64 INT106835 Positive_regulation of Localization of ARRB1 1 0.15 0.11 1.04
65 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
66 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
67 INT108943 Positive_regulation of Negative_regulation of Arrb2 1 0.61 0.06 0.97
68 INT60140 Localization of TRIM13 1 0.53 0 0.94
69 INT180136 Localization of SIRT2 15 0.12 1.42 0.88
70 INT32948 Negative_regulation of Binding of Trim13 1 0.41 0 0.86
71 INT41819 Regulation of TRIM13 2 0.44 0.2 0.85
72 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
73 INT323735 Regulation of FAF1 1 0.21 1.69 0.8
74 INT85678 Binding of Arrb1 1 0.20 0.09 0.78
75 INT181326 Binding of TNFAIP1 2 0.29 0.81 0.74
76 INT29924 Negative_regulation of Gene_expression of Trim13 1 0.34 0 0.74
77 INT323724 Gene_expression of FAF1 9 0.61 6.92 0.73
78 INT180139 Protein_catabolism of SIRT2 11 0.14 1.1 0.72
79 INT116081 Negative_regulation of Binding of ARRB1 1 0.41 0 0.72
80 INT77406 Negative_regulation of Negative_regulation of ARRB1 1 0.47 0 0.71
81 INT77401 Regulation of Regulation of ARRB1 1 0.25 0 0.69
82 INT274725 Regulation of TBL1XR1 5 0.11 2.08 0.64
83 INT230410 Negative_regulation of Gene_expression of TNFAIP1 3 0.16 3.67 0.63
84 INT196939 Gene_expression of Stub1 10 0.18 1.67 0.59
85 INT170695 Binding of Siah1a 1 0.48 1.19 0.59
86 INT147679 Binding of Arrb2 1 0.24 0.22 0.58
87 INT33731 Negative_regulation of TRIM13 1 0.41 0.26 0.55
88 INT181325 Positive_regulation of TNFAIP1 4 0.36 4.64 0.52
89 INT117926 Positive_regulation of Gene_expression of BIRC2 1 0.48 3.25 0.52
90 INT240206 Negative_regulation of RBX1 1 0.08 0.15 0.51
91 INT72378 Positive_regulation of Phosphorylation of Trim13 1 0.49 0.08 0.51
92 INT226164 Gene_expression of Trim63 5 0.68 4.77 0.49
93 INT89258 Localization of STUB1 3 0.14 0.67 0.49
94 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
95 INT209013 Regulation of Stub1 1 0.06 0.29 0.46
96 INT274724 Positive_regulation of TBL1XR1 5 0.12 2.74 0.45
97 INT117919 Negative_regulation of BIRC2 4 0.30 3.72 0.45
98 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
99 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
100 INT167616 Protein_catabolism of Ppp2cb 1 0.02 0.87 0.42
101 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
102 INT180142 Negative_regulation of SIRT2 10 0.07 0.19 0.41
103 INT180138 Negative_regulation of Gene_expression of SIRT2 2 0.07 0.19 0.41
104 INT168112 Phosphorylation of Arrb2 1 0.00 0 0.41
105 INT40183 Regulation of Binding of Trim13 1 0.44 0 0.41
106 INT216873 Binding of TBL1XR1 3 0.36 4.44 0.4
107 INT244151 Localization of DDB1 1 0.02 0.05 0.4
108 INT203081 Gene_expression of Trim63 2 0.56 1.53 0.39
109 INT156120 Localization of Arrb1 1 0.00 0 0.38
110 INT117923 Positive_regulation of BIRC2 1 0.48 2.5 0.38
111 INT150812 Regulation of Regulation of Arrb2 1 0.26 0 0.38
112 INT156119 Positive_regulation of Localization of Arrb1 1 0.00 0 0.38
113 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
114 INT144854 Gene_expression of STUB1 10 0.13 2.03 0.31
115 INT226170 Positive_regulation of Gene_expression of Trim63 5 0.44 3.96 0.31
116 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
117 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
118 INT323743 Positive_regulation of Gene_expression of FAF1 1 0.55 3.05 0.29
119 INT203067 Positive_regulation of Gene_expression of Trim63 2 0.50 0.92 0.28
120 INT180144 Binding of SIRT2 57 0.06 1.29 0.27
121 INT144855 Positive_regulation of STUB1 3 0.08 0.59 0.26
122 INT274742 Localization of TBL1XR1 2 0.24 1.4 0.26
123 INT100277 Positive_regulation of Gene_expression of TBL1XR1 5 0.19 1.9 0.25
124 INT142864 Positive_regulation of Phosphorylation of ARRB1 1 0.01 0 0.25
125 INT170714 Regulation of Gene_expression of Siah1a 1 0.61 0.71 0.25
126 INT142865 Phosphorylation of ARRB1 1 0.01 0 0.25
127 INT203471 Localization of Stub1 1 0.23 0.5 0.21
128 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
129 INT329047 Positive_regulation of TRIM63 1 0.06 1.27 0.2
130 INT226171 Protein_catabolism of Trim63 1 0.24 1.85 0.19
131 INT224095 Phosphorylation of ARRB2 1 0.61 0.13 0.19
132 INT20828 Positive_regulation of Negative_regulation of TNFAIP1 1 0.36 0.1 0.19
133 INT175663 Positive_regulation of SIRT2 56 0.14 3.58 0.17
134 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
135 INT233124 Positive_regulation of Gene_expression of SIRT2 17 0.04 0.16 0.14
136 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
137 INT334236 Positive_regulation of Rnf216 1 0.00 0.78 0.14
138 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
139 INT170700 Positive_regulation of Gene_expression of Siah1a 1 0.50 0.36 0.13
140 INT281604 Negative_regulation of Gene_expression of Trim63 1 0.42 0.65 0.13
141 INT324792 Regulation of TRIM63 1 0.03 0.09 0.12
142 INT170710 Negative_regulation of Siah1a 1 0.43 0.1 0.12
143 INT226183 Negative_regulation of Gene_expression of Trim63 1 0.12 0.68 0.12
144 INT281585 Binding of Trim63 1 0.27 0.59 0.12
145 INT181323 Regulation of TNFAIP1 4 0.35 0.92 0.11
146 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
147 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
148 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
149 INT170701 Negative_regulation of Localization of Siah1a 1 0.42 0 0.11
150 INT170696 Localization of Siah1a 1 0.74 0 0.11
151 INT170699 Positive_regulation of Siah1a 1 0.50 0.08 0.1
152 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
153 INT244174 Positive_regulation of DDB1 1 0.01 0.41 0.09
154 INT184167 Binding of STUB1 5 0.07 0.72 0.08
155 INT243617 Binding of Stub1 3 0.09 0.16 0.08
156 INT334248 Regulation of Rnf216 1 0.00 0.62 0.08
157 INT264170 Binding of BIRC2 1 0.01 1.19 0.08
158 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
159 INT256136 Negative_regulation of Binding of Sirt1 1 0.30 0.5 0.07
160 INT244138 Transcription of DDB1 1 0.02 0 0.06
161 INT170698 Regulation of Siah1a 1 0.45 0.36 0.06
162 INT299170 Positive_regulation of Localization of TBL1XR1 1 0.16 0.87 0.06
163 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
164 INT170704 Negative_regulation of Binding of Siah1a 1 0.42 0 0.06
165 INT256137 Positive_regulation of Regulation of Sirt1 1 0.36 0.32 0.05
166 INT281595 Regulation of Binding of Trim63 1 0.33 0.32 0.05
167 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
168 INT190625 Transcription of TRIM63 1 0.02 0.27 0.05
169 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
170 INT256129 Negative_regulation of Gene_expression of Sirt1 1 0.31 0.4 0.05
171 INT226168 Regulation of Protein_catabolism of Trim63 1 0.12 0.56 0.05
172 INT222291 Positive_regulation of Trim63 3 0.50 0.94 0.04
173 INT281601 Regulation of Trim63 1 0.14 0.17 0.04
174 INT322590 Regulation of BIRC2 1 0.11 1.76 0.04
175 INT281592 Regulation of Gene_expression of Trim63 1 0.33 0.17 0.04
176 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
177 INT270038 Positive_regulation of Positive_regulation of Sirt1 2 0.43 0.44 0.03
178 INT246622 Phosphorylation of Sirt1 2 0.74 0.56 0.03
179 INT323733 Binding of FAF1 1 0.29 0.05 0.03
180 INT182999 Negative_regulation of Gene_expression of STUB1 1 0.08 0.31 0.03
181 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
182 INT204349 Regulation of SIRT1 8 0.61 1.99 0
183 INT256134 Localization of Sirt1 5 0.50 2.99 0
184 INT233125 Positive_regulation of Positive_regulation of SIRT2 4 0.04 0 0
185 INT204353 Transcription of SIRT1 3 0.68 0.67 0
186 INT180140 Regulation of SIRT2 3 0.04 0 0
187 INT244139 Gene_expression of DDB1 3 0.02 0.45 0
188 INT222292 Transcription of Trim63 3 0.52 0.32 0
189 INT233126 Regulation of Gene_expression of SIRT2 2 0.03 0 0
190 INT79864 Positive_regulation of Protein_catabolism of TRIM13 2 0.31 0 0
191 INT180146 Positive_regulation of Binding of SIRT2 2 0.08 0 0
192 INT200277 Positive_regulation of Gene_expression of Stub1 2 0.06 0 0
193 INT196230 Regulation of STUB1 2 0.05 0.8 0
194 INT181322 Positive_regulation of Gene_expression of TNFAIP1 2 0.39 3.28 0
195 INT222294 Positive_regulation of Transcription of Trim63 2 0.36 0.17 0
196 INT217331 Binding of UBE2I 1 0.12 2.88 0
197 INT209699 Negative_regulation of STUB1 1 0.07 0.41 0
198 INT281593 Regulation of Positive_regulation of Trim63 1 0.33 0 0
199 INT303351 Binding of Rbx1 1 0.18 0 0
200 INT233120 Regulation of Binding of SIRT2 1 0.03 0 0
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