GO:0043179

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Name rhythmic excitation
Categary Process
Go Slim No
Go Link GO:0043179
Unique Molecular Interactions 224
Total Molecular Interactions 327
Total Single Events 2485
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for rhythmic excitation. They are ordered first by their pain relevance and then by number of times they were reported for rhythmic excitation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT12140 Ngf Regulation of Chat 1 0.44 1.67 2.18
2 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
3 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
4 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
5 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
6 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
7 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
8 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
9 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
10 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
11 INT12138 Ins1 Negative_regulation of Chat 1 0.27 0.71 1.01
12 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
13 INT56742 LIF Positive_regulation of Chat 1 0.02 0.2 0.98
14 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
15 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
16 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
17 INT251706 Chat Regulation of Gene_expression of Acot1 1 0.06 1.64 0.85
18 INT251708 Chat Regulation of Acot1 1 0.03 1.64 0.84
19 INT140447 Ngf Regulation of Scn9a 1 0.69 0.16 0.84
20 INT12142 Ins1 Regulation of Chat 1 0.24 0.69 0.84
21 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
22 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
23 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
24 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
25 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
26 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
27 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
28 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
29 INT18447 Binding of Ache and Chat 2 0.33 0.33 0.73
30 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
31 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
32 INT68211 Binding of Calca and Chat 1 0.37 0 0.71
33 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
34 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
35 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
36 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
37 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
38 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
39 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
40 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
41 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
42 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
43 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
44 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
45 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
46 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
47 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
48 INT106346 Mtpn Regulation of Chat 1 0.06 0 0.52
49 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
50 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
51 INT12143 Ngf Positive_regulation of Chat 1 0.45 0.29 0.49
52 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
53 INT56736 Cntf Positive_regulation of Chat 1 0.00 0.1 0.49
54 INT56745 CNTF Positive_regulation of Chat 1 0.02 0.1 0.49
55 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
56 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
57 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
58 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
59 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
60 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
61 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
62 INT205567 Regulation of Binding of Fgf1 and Chat 1 0.29 0.28 0.41
63 INT205566 Binding of Fgf1 and Chat 1 0.24 0.28 0.41
64 INT61660 Binding of CHAT and CYP21A2 1 0.00 0 0.4
65 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
66 INT79504 Binding of Gad1 and Chat 1 0.35 0 0.38
67 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
68 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
69 INT79507 Binding of Pvalb and Chat 1 0.06 0 0.38
70 INT173704 Binding of PCOS1 and Edn1 1 0.01 0.99 0.37
71 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
72 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
73 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
74 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
75 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
76 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
77 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
78 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
79 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
80 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
81 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
82 INT71519 Edn1 Positive_regulation of Gene_expression of Adarb1 1 0.02 0.48 0.31
83 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
84 INT22722 Binding of Chat and Hc3 1 0.39 0 0.28
85 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26
86 INT281980 Scn9a Positive_regulation of MDK 1 0.06 0.24 0.26
87 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
88 INT178095 EDN1 Positive_regulation of MMP3 1 0.04 0.88 0.24
89 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24
90 INT178085 EDN1 Positive_regulation of MMP7 1 0.06 0.89 0.24
91 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
92 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
93 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
94 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
95 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
96 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24
97 INT182272 EDN1 Regulation of Gene_expression of MMP13 1 0.26 0.87 0.22
98 INT91686 Mb Positive_regulation of Edn1 1 0.03 0.29 0.22
99 INT182265 EDN1 Positive_regulation of NOS2 1 0.24 0.56 0.22
100 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21
101 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
102 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
103 INT182258 EDN1 Positive_regulation of Positive_regulation of MMP1 1 0.15 0.47 0.19
104 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19
105 INT222543 Il1a Regulation of Chat 1 0.01 0.64 0.19
106 INT219915 Edn1 Regulation of Positive_regulation of Trpv1 1 0.33 0 0.18
107 INT140096 Gtf3a Positive_regulation of Gene_expression of Edn1 1 0.02 0.44 0.18
108 INT171386 Edn1 Positive_regulation of Mapk1 1 0.05 0.13 0.18
109 INT60778 Edn1 Positive_regulation of EDNRA 1 0.00 0 0.18
110 INT284450 Edn1 Positive_regulation of Gene_expression of MMP9 1 0.01 0.3 0.18
111 INT140094 Ifng Regulation of Gene_expression of Edn1 1 0.18 0.44 0.18
112 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
113 INT203759 Binding of EDN1 and TNF 1 0.16 0.71 0.16
114 INT324899 Edn1 Positive_regulation of Positive_regulation of Mmp9 1 0.10 0.66 0.16
115 INT94022 Positive_regulation of Binding of EDN1 and INSRR 1 0.06 0 0.16
116 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
117 INT94021 Binding of EDN1 and EDN2 1 0.26 0 0.16
118 INT94014 Positive_regulation of Binding of EDN1 and EDN3 1 0.36 0 0.16
119 INT324894 Edn1 Positive_regulation of Gene_expression of Mmp3 1 0.07 0.66 0.16
120 INT160929 Chat Positive_regulation of Penk 1 0.35 1.18 0.15
121 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15
122 INT21509 Agt Regulation of Edn1 1 0.53 0 0.15
123 INT182261 EDN1 Regulation of Gene_expression of MMP1 1 0.17 0.7 0.15
124 INT50500 Edn1 Positive_regulation of PTGS1 1 0.00 0.07 0.14
125 INT324898 Ece1 Regulation of Gene_expression of Edn1 1 0.17 0.8 0.14
126 INT161799 Positive_regulation of Binding of ECE1 and EDN1 1 0.07 0.68 0.14
127 INT147863 Binding of CHAT and SLC18A3 1 0.34 0.8 0.14
128 INT332689 Binding of Edn1 and Ros1 1 0.08 0.71 0.14
129 INT347868 Ntf3 Negative_regulation of Negative_regulation of Chat 1 0.03 0.22 0.13
130 INT161798 Positive_regulation of Binding of EDN1 and ING1 1 0.06 0.66 0.13
131 INT161800 Binding of EDN1 and ING1 1 0.05 0.65 0.13
132 INT178083 EDN1 Positive_regulation of Gene_expression of VEGFA 1 0.09 1.8 0.13
133 INT206065 EDN1 Positive_regulation of IL6 1 0.03 0.47 0.12
134 INT178101 EDN1 Negative_regulation of Phosphorylation of BCL2 1 0.03 1 0.12
135 INT77863 EDN1 Positive_regulation of POMC 1 0.50 0.34 0.12
136 INT182273 EDN1 Regulation of Gene_expression of BAD 1 0.11 0.73 0.12
137 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11
138 INT182270 EDN1 Positive_regulation of Gene_expression of MMP1 1 0.18 0.55 0.1
139 INT181569 Binding of Edn1 and Mapk8 1 0.09 2.7 0.1
140 INT181570 Binding of Edn1 and Mapk1 1 0.13 2.72 0.1
141 INT6674 Edn1 Positive_regulation of Gene_expression of FOS 1 0.08 0.19 0.1
142 INT139476 Edn1 Positive_regulation of Ednra 1 0.00 1.07 0.1
143 INT201721 Ngf Regulation of Chat 1 0.02 0.4 0.1
144 INT10904 Edn1 Regulation of Localization of Nppb 1 0.22 0.54 0.1
145 INT92956 Edn1 Regulation of Positive_regulation of Nos2 1 0.18 0.17 0.09
146 INT332688 Ros1 Positive_regulation of Binding of Edn1 1 0.10 0.57 0.09
147 INT230750 Crp Positive_regulation of Edn1 1 0.10 0.27 0.09
148 INT92957 Edn1 Regulation of Gene_expression of Nos2 1 0.18 0.17 0.09
149 INT242257 Binding of EDN1 and ELF3 1 0.17 0.21 0.08
150 INT181584 Binding of EDNRB and Edn1 1 0.46 0.85 0.08
151 INT181583 Binding of Edn1 and Positive_regulation of NOS1 1 0.02 0.86 0.08
152 INT178100 Gene_expression of EDNRB Positive_regulation of EDN1 1 0.17 1.11 0.08
153 INT113369 Edn1 Regulation of Adarb1 1 0.02 0.14 0.08
154 INT178081 Negative_regulation of EDN1 Positive_regulation of HIF1A 1 0.04 1.18 0.08
155 INT251710 Fig4 Regulation of Chat 1 0.03 0.23 0.08
156 INT251705 Fig4 Regulation of Localization of Chat 1 0.05 0.23 0.08
157 INT178080 EDN1 Positive_regulation of HIF1A 1 0.05 1.05 0.08
158 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07
159 INT182269 EDN1 Positive_regulation of Localization of MMP1 1 0.17 0.31 0.07
160 INT192908 Edn1 Positive_regulation of Ednra 1 0.21 0.35 0.07
161 INT242258 ELF3 Negative_regulation of EDN1 1 0.15 0.09 0.07
162 INT309941 Edn1 Positive_regulation of Tlr2 1 0.02 1.31 0.07
163 INT172382 AGT Positive_regulation of Localization of EDN1 1 0.03 0.34 0.07
164 INT182268 Negative_regulation of MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
165 INT192907 Edn1 Positive_regulation of Ednrb 1 0.10 0.35 0.07
166 INT182274 MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
167 INT191219 Edn1 Positive_regulation of Amigo2 1 0.06 1.26 0.07
168 INT324896 Ece1 Positive_regulation of Negative_regulation of Edn1 1 0.19 0.42 0.07
169 INT172381 AVP Positive_regulation of Localization of EDN1 1 0.01 0.34 0.07
170 INT178096 EDN1 Positive_regulation of Gene_expression of EDNRB 1 0.17 1.01 0.07
171 INT181645 Edn1 Positive_regulation of NOS3 1 0.02 0.21 0.07
172 INT178090 EDN1 Positive_regulation of Phosphorylation of GJA1 1 0.09 0.88 0.06
173 INT191216 Binding of Edn1 and Cotl1 1 0.14 0.63 0.05
174 INT182259 EDN1 Positive_regulation of Gene_expression of TIMP1 1 0.01 0.27 0.05
175 INT180668 Edn1 Positive_regulation of Gene_expression of Col1a1 1 0.02 0 0.05
176 INT182264 EDN1 Positive_regulation of Positive_regulation of MAPK14 1 0.26 0.1 0.05
177 INT180667 Edn1 Regulation of Ecm1 1 0.04 0 0.05
178 INT213263 INS Positive_regulation of EDN1 1 0.12 0.54 0.04
179 INT178091 EDN1 Positive_regulation of Gene_expression of PTGER2 1 0.01 0.74 0.04
180 INT353314 Edn1 Positive_regulation of Kalrn 1 0.03 0.21 0.04
181 INT229371 Positive_regulation of Pparg Negative_regulation of Gene_expression of Edn1 1 0.01 0.92 0.04
182 INT178098 EDN1 Positive_regulation of Transcription of VEGFA 1 0.08 0.76 0.04
183 INT332684 Binding of Edn1 and Lep 1 0.09 1.11 0.04
184 INT306514 EDN1 Positive_regulation of EDNRB 1 0.11 0.98 0.04
185 INT353317 Edn1 Positive_regulation of RHOA 1 0.19 0.16 0.04
186 INT178082 EDN1 Positive_regulation of VEGFA 1 0.08 0.77 0.04
187 INT323623 Binding of Adm and Edn1 1 0.04 0.77 0.03
188 INT242601 Gdnf Positive_regulation of Chat 1 0.29 0.15 0.03
189 INT239229 Regulation of Binding of Edn1 and Ednra 1 0.01 0.37 0.03
190 INT321407 EDN1 Positive_regulation of Phosphorylation of IRS1 1 0.06 1.07 0.03
191 INT345298 NLRP3 Positive_regulation of Localization of Edn1 1 0.01 0.94 0.03
192 INT256228 EDNRB Positive_regulation of EDN1 1 0.26 0.62 0.03
193 INT101159 Gene_expression of Bcl2 Positive_regulation of Gene_expression of CHAT 1 0.31 0.96 0.03
194 INT239225 Binding of Edn1 and Ednrb 1 0.02 0.36 0.03
195 INT292081 Binding of EDN1 and NCOR2 1 0.00 0.98 0.03
196 INT242611 Nrtn Positive_regulation of Chat 1 0.26 0.15 0.03
197 INT239228 Regulation of Binding of Edn1 and Ednrb 1 0.02 0.37 0.03
198 INT239224 Positive_regulation of Binding of Edn1 and Ednrb 1 0.02 0.37 0.03
199 INT213030 Hdl1 Regulation of Gene_expression of Edn1 1 0.06 0.88 0
200 INT10901 Edn1 Positive_regulation of Localization of Nppb 1 0.39 0.68 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for rhythmic excitation. They are ordered first by their pain relevance and then by number of times they were reported in rhythmic excitation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
2 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
3 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
4 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
5 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
6 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
7 INT5048 Binding of Edn1 55 0.47 18.86 19.16
8 INT6381 Negative_regulation of Chat 51 0.59 19.68 15.86
9 INT4851 Positive_regulation of Chat 53 0.70 9.21 15.11
10 INT16266 Gene_expression of Chat 80 0.67 16.14 15.01
11 INT11945 Regulation of Chat 38 0.62 7.75 14.97
12 INT9191 Localization of EDN1 94 0.81 57.01 14.78
13 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
14 INT4736 Gene_expression of Chat 67 0.77 17.15 14.24
15 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
16 INT6365 Localization of Edn1 56 0.81 18.84 13.83
17 INT41728 Gene_expression of CHAT 65 0.75 42.19 12.73
18 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
19 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
20 INT6361 Localization of Edn1 30 0.81 19.09 9.7
21 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
22 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
23 INT10237 Binding of EDN1 40 0.48 16 8.48
24 INT15308 Localization of Chat 29 0.81 2.35 8.47
25 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
26 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
27 INT42312 Negative_regulation of Chat 14 0.54 6.13 5.44
28 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
29 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
30 INT48449 Regulation of Chat 11 0.61 4.24 3.64
31 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
32 INT53374 Binding of Edn1 17 0.43 11.66 2.98
33 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
34 INT47386 Negative_regulation of CHAT 5 0.29 1.63 2.61
35 INT11943 Transcription of Chat 10 0.70 1.55 2.36
36 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
37 INT140400 Binding of Scn9a 4 0.36 3.59 2.15
38 INT22282 Positive_regulation of Chat 8 0.67 2.82 2.12
39 INT69690 Gene_expression of Scn9a 6 0.78 2.08 2.09
40 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
41 INT87374 Positive_regulation of CHAT 7 0.67 3.91 1.96
42 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
43 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
44 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
45 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
46 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
47 INT69691 Transcription of Scn9a 2 0.53 1.14 1.68
48 INT222970 Localization of Chat 6 0.73 0.96 1.66
49 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
50 INT222971 Negative_regulation of Negative_regulation of Chat 1 0.38 1.25 1.53
51 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
52 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
53 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48
54 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48
55 INT32900 Negative_regulation of Positive_regulation of Chat 3 0.43 1.91 1.45
56 INT242532 Positive_regulation of Gene_expression of Chat 14 0.50 2.38 1.44
57 INT58452 Positive_regulation of Negative_regulation of Chat 4 0.50 1.99 1.35
58 INT140446 Positive_regulation of Scn9a 2 0.49 0.35 1.19
59 INT17802 Transcription of Edn1 6 0.24 6.31 1.18
60 INT44621 Binding of Chat 5 0.45 0.87 1.15
61 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
62 INT57188 Regulation of Gene_expression of Chat 4 0.45 1.89 1.12
63 INT222968 Negative_regulation of Gene_expression of Chat 8 0.42 1.1 1.1
64 INT227604 Transcription of Chat 4 0.52 1.01 1.08
65 INT57189 Negative_regulation of Gene_expression of Chat 5 0.56 1.35 1.07
66 INT69803 Regulation of Localization of Edn1 3 0.62 0.79 0.98
67 INT30316 Regulation of CHAT 6 0.43 1.95 0.96
68 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95
69 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95
70 INT49254 Transcription of EDN1 5 0.69 2.42 0.94
71 INT152081 Phosphorylation of Edn1 1 0.53 0.39 0.9
72 INT56200 Negative_regulation of Negative_regulation of Chat 3 0.25 1.38 0.88
73 INT193070 Localization of CHAT 3 0.17 1.03 0.86
74 INT61591 Negative_regulation of Localization of EDN1 11 0.59 2.09 0.85
75 INT57433 Positive_regulation of Binding of EDN1 3 0.49 0.62 0.82
76 INT61121 Regulation of Regulation of Edn1 1 0.43 0.2 0.75
77 INT59970 Positive_regulation of Binding of Edn1 2 0.40 1.11 0.71
78 INT21957 Negative_regulation of Negative_regulation of Edn1 5 0.43 1.34 0.69
79 INT100626 Transcription of CHAT 4 0.51 1.94 0.69
80 INT44622 Positive_regulation of Binding of Chat 3 0.39 0.71 0.68
81 INT88188 Negative_regulation of Transcription of Chat 1 0.51 0 0.68
82 INT242541 Regulation of Gene_expression of Chat 3 0.43 0.67 0.67
83 INT49252 Positive_regulation of Localization of EDN1 17 0.69 6.55 0.66
84 INT100396 Transcription of Edn1 7 0.69 2.48 0.66
85 INT49256 Regulation of Positive_regulation of EDN1 2 0.45 2.5 0.65
86 INT140399 Regulation of Scn9a 2 0.45 0.74 0.61
87 INT7153 Positive_regulation of Regulation of Edn1 2 0.35 1.97 0.57
88 INT135715 Negative_regulation of Localization of Edn1 5 0.42 1.7 0.56
89 INT63910 Regulation of Positive_regulation of Edn1 2 0.43 0.64 0.54
90 INT11942 Positive_regulation of Transcription of Chat 2 0.47 0.23 0.54
91 INT131641 Negative_regulation of Negative_regulation of Edn1 1 0.37 0.31 0.52
92 INT181581 Regulation of Positive_regulation of Edn1 4 0.23 3.76 0.51
93 INT106973 Positive_regulation of Gene_expression of CHAT 3 0.44 0.8 0.5
94 INT196398 Protein_catabolism of Chat 1 0.24 2.1 0.47
95 INT55372 Regulation of Localization of Edn1 2 0.38 0.64 0.46
96 INT57434 Regulation of Regulation of EDN1 1 0.40 0.47 0.44
97 INT151622 Positive_regulation of Gene_expression of Scn9a 1 0.43 1.17 0.43
98 INT85761 Positive_regulation of Gene_expression of Chat 5 0.30 1.43 0.39
99 INT81433 Negative_regulation of Positive_regulation of Edn1 4 0.39 0.81 0.38
100 INT113368 Regulation of Negative_regulation of Edn1 1 0.45 0.71 0.35
101 INT141013 Regulation of Gene_expression of Edn1 2 0.24 0.55 0.34
102 INT87388 Negative_regulation of Positive_regulation of CHAT 1 0.42 0.41 0.34
103 INT95831 Regulation of Negative_regulation of Chat 1 0.09 0 0.32
104 INT16368 Protein_catabolism of Edn1 2 0.72 0.18 0.31
105 INT84038 Protein_catabolism of Edn1 2 0.86 0.69 0.26
106 INT109433 Phosphorylation of Chat 1 0.15 0.65 0.24
107 INT218031 Regulation of Transcription of CHAT 1 0.27 0 0.24
108 INT67265 Positive_regulation of Negative_regulation of Edn1 1 0.61 0.05 0.21
109 INT297457 Regulation of Regulation of Chat 1 0.27 0.32 0.21
110 INT156920 Phosphorylation of EDN1 4 0.61 0.66 0.19
111 INT53372 Positive_regulation of Regulation of Edn1 1 0.50 0 0.19
112 INT100397 Regulation of Transcription of Edn1 1 0.00 0.1 0.19
113 INT314791 Binding of Chat 1 0.32 0 0.15
114 INT284152 Regulation of Transcription of EDN1 1 0.32 0.44 0.13
115 INT6362 Negative_regulation of Localization of Edn1 3 0.16 1.92 0.12
116 INT323950 Phosphorylation of Chat 1 0.09 0.93 0.11
117 INT15391 Negative_regulation of Positive_regulation of Edn1 2 0.07 0.1 0.1
118 INT170744 Positive_regulation of Transcription of Edn1 2 0.20 1.3 0.1
119 INT297461 Protein_catabolism of Chat 1 0.39 0.5 0.1
120 INT49257 Positive_regulation of Transcription of EDN1 2 0.46 1.1 0.08
121 INT126441 Negative_regulation of Transcription of Edn1 1 0.40 0.17 0.08
122 INT227603 Negative_regulation of Localization of Chat 1 0.12 0 0.07
123 INT227180 Localization of Scn9a 1 0.31 0 0.05
124 INT159025 Negative_regulation of Localization of Chat 1 0.39 0 0.04
125 INT227182 Regulation of Gene_expression of Scn9a 1 0.17 0 0.04
126 INT226593 Positive_regulation of Positive_regulation of Chat 1 0.20 0.65 0.04
127 INT227602 Negative_regulation of Transcription of Chat 1 0.12 0.18 0
128 INT280682 Positive_regulation of Transcription of Edn1 1 0.34 0 0
129 INT49261 Negative_regulation of Protein_catabolism of EDN1 1 0.58 0 0
130 INT314792 Positive_regulation of Localization of Chat 1 0.43 0 0
131 INT169264 Regulation of Localization of Chat 1 0.21 0.08 0
132 INT181578 Negative_regulation of Phosphorylation of Edn1 1 0.37 0.1 0
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