GO:0043202

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Name lysosomal lumen
Categary Component
Go Slim No
Go Link GO:0043202
Unique Molecular Interactions 78
Total Molecular Interactions 97
Total Single Events 937
Pain Genes Associated 20

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for lysosomal lumen. They are ordered first by their pain relevance and then by number of times they were reported for lysosomal lumen. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76
2 INT30134 Binding of TPP1 and S100A9 1 0.13 0.74 1.69
3 INT115271 Neu1 Positive_regulation of Coq10a 1 0.01 0.41 1.35
4 INT91813 Binding of FAS and FASLG 4 0.23 9.89 0.99
5 INT124742 ARSA Positive_regulation of Localization of CSF2 1 0.10 0.15 0.91
6 INT130769 FASLG Negative_regulation of Binding of FAS 1 0.10 0.66 0.86
7 INT124743 ARSA Negative_regulation of PTGER2 1 0.03 0.15 0.85
8 INT124744 ARSA Negative_regulation of Gene_expression of PTGER2 1 0.03 0.15 0.85
9 INT44503 Cubn Positive_regulation of Prl 1 0.18 0 0.74
10 INT302642 Binding of ARSA and TGFB1 1 0.05 0.28 0.68
11 INT94075 ARSA Negative_regulation of Gene_expression of IL4 1 0.28 0.26 0.62
12 INT302645 ARSA Positive_regulation of Gene_expression of TGFB1 1 0.08 0.28 0.55
13 INT544 Binding of ALB and GC 1 0.13 0 0.55
14 INT88024 Ifng Positive_regulation of Gene_expression of Faslg 2 0.50 1.19 0.53
15 INT302644 ARSA Positive_regulation of Gene_expression of TGFBR1 1 0.04 0.29 0.51
16 INT302647 ARSA Positive_regulation of TGFBR1 1 0.03 0.29 0.51
17 INT122107 Plbd2 Negative_regulation of Cdh2 1 0.03 0.42 0.5
18 INT302643 ARSA Positive_regulation of Localization of TGFB1 1 0.08 0.12 0.49
19 INT65007 DAK Negative_regulation of CTSA 1 0.03 0.35 0.48
20 INT254347 FASLG Negative_regulation of Gene_expression of CHI3L1 1 0.13 0.92 0.42
21 INT254350 FASLG Negative_regulation of Gene_expression of VEGFA 1 0.06 0.92 0.42
22 INT38269 Binding of TCN1 and CUBN 1 0.00 0.28 0.4
23 INT273893 ARSA Positive_regulation of HSD11B1 1 0.00 0.61 0.4
24 INT355018 Binding of FAS and Faslg 1 0.12 1.34 0.37
25 INT176373 IL18 Regulation of FASLG 1 0.41 0.4 0.35
26 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34
27 INT94073 ARSA Negative_regulation of Transcription of IL4 1 0.20 0.16 0.31
28 INT94076 ARSA Negative_regulation of Gene_expression of IL2 1 0.13 0.09 0.3
29 INT94072 ARSA Regulation of Gene_expression of IL2 1 0.07 0.09 0.29
30 INT45196 Cubn Negative_regulation of Prl 1 0.05 0 0.27
31 INT94074 ARSA Regulation of Gene_expression of IK 1 0.01 0.06 0.27
32 INT245920 Binding of GLA and TRPV1 1 0.09 0.36 0.26
33 INT173358 Gnaq Positive_regulation of SMPD1 1 0.01 0.13 0.23
34 INT60909 TPP1 Positive_regulation of Gh1 1 0.00 0 0.22
35 INT88022 Tnf Positive_regulation of Gene_expression of Faslg 1 0.26 0.76 0.2
36 INT287723 Oxt Regulation of Gene_expression of Plbd2 1 0.01 0.13 0.17
37 INT175328 FASLG Positive_regulation of FAS 1 0.01 0.9 0.17
38 INT91812 Binding of FASLG and TP53 1 0.04 1.1 0.16
39 INT234720 Cxcl1 Positive_regulation of Gene_expression of Faslg 1 0.08 0.2 0.16
40 INT234719 Cxcl1 Regulation of Gene_expression of Faslg 1 0.08 0.2 0.15
41 INT347807 GLA Positive_regulation of Positive_regulation of A4GALT 1 0.05 1.57 0.13
42 INT192330 UBR7 Negative_regulation of Positive_regulation of PDGFRB 1 0.01 0.54 0.12
43 INT60906 Positive_regulation of GH1 Negative_regulation of TPP1 1 0.00 0 0.1
44 INT60905 GH1 Negative_regulation of TPP1 1 0.00 0 0.1
45 INT277090 VEGFA Positive_regulation of Negative_regulation of Faslg 1 0.02 1.67 0.09
46 INT91810 Binding of FASLG and TNF 1 0.05 0.92 0.08
47 INT244639 AGK Negative_regulation of PDGFRB 1 0.01 0.69 0.08
48 INT163473 Binding of GM2A and GRDX 1 0.27 0.35 0.08
49 INT102886 Binding of GBE1 and CTSA 1 0.00 0 0.07
50 INT298006 CHDM Positive_regulation of Gene_expression of PDGFRB 1 0.16 1.08 0.07
51 INT192329 UBR7 Negative_regulation of Phosphorylation of PDGFRB 1 0.01 0.06 0.07
52 INT335712 Binding of FASLG and CD8A 1 0.18 0.9 0.06
53 INT279291 PDGFA Positive_regulation of PDGFRB 1 0.16 1.02 0.06
54 INT335715 Binding of FASLG and CD4 1 0.22 0.9 0.06
55 INT249416 Binding of Scarb2 and Napa 1 0.02 0 0.05
56 INT279287 PDGFRB Regulation of CDCP1 1 0.01 0.98 0.05
57 INT186185 Binding of SCARB1 and SCARB2 1 0.22 0.58 0.05
58 INT14440 Binding of GLB1 and NEU1 1 0.00 0.09 0.05
59 INT186192 Binding of SCARB2 and TBP 1 0.02 0.58 0.05
60 INT186183 Binding of SCARB2 and SASH3 1 0.00 0.49 0.04
61 INT292092 Binding of PDGFRB and TXK 1 0.05 1.53 0.04
62 INT292079 Negative_regulation of Binding of PDGFRB and TXK 1 0.06 1.54 0.04
63 INT245922 Binding of GLA and FIBP 1 0.00 0 0.03
64 INT210154 TXN Regulation of Gene_expression of FASLG 1 0.09 0.23 0.03
65 INT245917 Binding of GLA and ABCC1 1 0.05 0 0.03
66 INT279277 PDGFB Positive_regulation of PDGFRB 1 0.14 0.52 0.03
67 INT279241 Binding of ELF3 and GLA 1 0.20 0.53 0
68 INT245925 GLA Regulation of TRPV1 1 0.07 0 0
69 INT106380 ARSA Regulation of Gene_expression of BAX 1 0.06 0.12 0
70 INT204927 Binding of LGMN and IL33 1 0.00 0.52 0
71 INT279242 Negative_regulation of Binding of GLA and SH3GL3 1 0.08 1.22 0
72 INT279240 Binding of GLA and SH3GL3 1 0.07 1.21 0
73 INT292091 MIR1200 Negative_regulation of PDGFRB 1 0.01 1.24 0
74 INT279283 TXK Regulation of PDGFRB 1 0.06 0.68 0
75 INT295426 Binding of KIT and PDGFRB 1 0.24 0.4 0
76 INT254044 Binding of BGLAP and NEU4 1 0.04 0.29 0
77 INT314679 NEU1 Negative_regulation of TP53 1 0.12 1.23 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for lysosomal lumen. They are ordered first by their pain relevance and then by number of times they were reported in lysosomal lumen. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8249 Positive_regulation of Cubn 15 0.66 4.05 9.35
2 INT13893 Negative_regulation of Cubn 9 0.36 1.78 9.24
3 INT86851 Gene_expression of Faslg 45 0.75 24.42 9.21
4 INT95133 Gene_expression of FASLG 38 0.75 44.09 7.51
5 INT57562 Gene_expression of GLA 52 0.77 24.62 6.14
6 INT3550 Negative_regulation of GLA 52 0.59 33.93 5.26
7 INT171033 Localization of SMPD1 15 0.16 11.92 5.16
8 INT171019 Gene_expression of SMPD1 26 0.27 12.08 5.08
9 INT88019 Positive_regulation of Gene_expression of Faslg 16 0.67 11.31 5.05
10 INT1701 Localization of Neu1 11 0.69 6.36 4.18
11 INT18822 Regulation of Cubn 4 0.27 0.17 3.74
12 INT545 Binding of GC 15 0.45 10.74 3.47
13 INT27446 Negative_regulation of CTSA 11 0.57 5.58 3.08
14 INT171013 Regulation of SMPD1 4 0.11 4.84 2.74
15 INT39266 Negative_regulation of Localization of Neu1 6 0.30 4.66 2.6
16 INT171032 Positive_regulation of SMPD1 9 0.12 8.94 2.52
17 INT88572 Positive_regulation of Plbd2 4 0.03 0.37 2.43
18 INT95136 Binding of FASLG 6 0.33 8.01 2.41
19 INT137960 Positive_regulation of FASLG 8 0.67 6.5 2.34
20 INT93395 Transcription of Faslg 6 0.51 5.64 2.26
21 INT163545 Gene_expression of PDGFRB 39 0.78 25.5 2.2
22 INT30137 Negative_regulation of TPP1 5 0.37 0.96 2.2
23 INT195191 Gene_expression of Cubn 2 0.06 0 2.17
24 INT88016 Negative_regulation of Gene_expression of Faslg 5 0.54 2.18 1.93
25 INT73359 Gene_expression of GLB1 8 0.75 3.18 1.92
26 INT102147 Negative_regulation of Faslg 5 0.19 4.56 1.92
27 INT41633 Positive_regulation of Positive_regulation of Cubn 2 0.48 0.1 1.89
28 INT2606 Localization of NEU1 10 0.41 4.6 1.82
29 INT130775 Regulation of FASLG 4 0.30 5.8 1.82
30 INT37758 Gene_expression of GC 10 0.75 7.09 1.75
31 INT30138 Binding of TPP1 1 0.16 0.74 1.69
32 INT93394 Positive_regulation of Transcription of Faslg 1 0.24 3.57 1.57
33 INT302658 Binding of ARSA 1 0.07 0.92 1.53
34 INT99097 Positive_regulation of GLB1 7 0.49 3.45 1.52
35 INT137819 Binding of Faslg 3 0.09 1.78 1.51
36 INT236434 Localization of Plbd2 1 0.01 0 1.49
37 INT88015 Positive_regulation of Faslg 5 0.65 5.73 1.44
38 INT20233 Negative_regulation of SMPD1 8 0.51 4.19 1.4
39 INT27459 Negative_regulation of Plbd2 2 0.06 0.08 1.38
40 INT287718 Gene_expression of Plbd2 1 0.03 0.36 1.38
41 INT8339 Negative_regulation of GC 12 0.57 4.9 1.37
42 INT135551 Positive_regulation of Gene_expression of FASLG 2 0.67 6.71 1.26
43 INT130774 Transcription of FASLG 5 0.67 2.02 1.22
44 INT257952 Positive_regulation of CUBN 1 0.07 0.61 1.22
45 INT44498 Localization of Cubn 2 0.34 0.38 1.19
46 INT36179 Regulation of GLA 11 0.44 6.56 1.12
47 INT41333 Negative_regulation of Positive_regulation of Cubn 2 0.15 0.47 1.12
48 INT124317 Regulation of Gene_expression of FASLG 2 0.23 1.54 1.1
49 INT35104 Positive_regulation of GC 6 0.11 4.99 1.08
50 INT171038 Positive_regulation of Localization of SMPD1 2 0.08 1.8 0.99
51 INT142495 Regulation of LGMN 2 0.14 0.13 0.91
52 INT104298 Negative_regulation of ARSA 2 0.28 0.56 0.89
53 INT2607 Negative_regulation of Localization of NEU1 3 0.30 1.52 0.88
54 INT130770 Positive_regulation of Transcription of FASLG 1 0.22 0.68 0.87
55 INT57560 Positive_regulation of GLA 14 0.54 5.01 0.83
56 INT171030 Positive_regulation of Gene_expression of SMPD1 2 0.09 0.92 0.82
57 INT96649 Gene_expression of ARSA 5 0.65 2.82 0.8
58 INT86852 Regulation of Faslg 3 0.42 1.67 0.79
59 INT302660 Positive_regulation of Gene_expression of ARSA 1 0.10 0.88 0.77
60 INT44500 Regulation of Localization of Cubn 1 0.20 0 0.75
61 INT164756 Negative_regulation of PDGFRB 32 0.57 21.69 0.72
62 INT171024 Negative_regulation of Localization of SMPD1 1 0.07 1.29 0.72
63 INT72654 Regulation of Localization of Neu1 1 0.02 0.34 0.72
64 INT257951 Localization of CUBN 1 0.07 0 0.71
65 INT20316 Regulation of Neu1 1 0.05 0.19 0.7
66 INT257948 Binding of CUBN 1 0.05 0 0.7
67 INT2384 Regulation of CTSA 4 0.44 2.22 0.69
68 INT164258 Positive_regulation of Gene_expression of GLA 6 0.47 0.55 0.65
69 INT95135 Negative_regulation of Gene_expression of FASLG 4 0.20 2.99 0.64
70 INT13894 Regulation of Negative_regulation of Cubn 1 0.13 0.09 0.63
71 INT124269 Binding of Cubn 1 0.28 0.2 0.59
72 INT45208 Regulation of NEU1 2 0.10 3.79 0.58
73 INT43158 Regulation of TPP1 1 0.23 0 0.55
74 INT97860 Gene_expression of CTSA 8 0.43 2.22 0.54
75 INT171043 Negative_regulation of Gene_expression of SMPD1 2 0.08 1.15 0.53
76 INT73164 Negative_regulation of Gene_expression of GC 1 0.41 0.06 0.52
77 INT14450 Binding of NEU1 7 0.14 5.1 0.5
78 INT128569 Regulation of Positive_regulation of Cubn 1 0.09 0 0.49
79 INT104297 Regulation of ARSA 1 0.18 1.05 0.49
80 INT73200 Positive_regulation of PDGFRB 10 0.67 9.67 0.48
81 INT85659 Gene_expression of TPP1 2 0.53 1.84 0.48
82 INT45878 Gene_expression of NEU1 14 0.65 7.28 0.47
83 INT142484 Positive_regulation of Gene_expression of GLB1 1 0.49 2.33 0.45
84 INT27457 Transcription of Plbd2 1 0.11 0 0.45
85 INT2610 Positive_regulation of Localization of NEU1 2 0.12 0.7 0.44
86 INT302661 Negative_regulation of Negative_regulation of ARSA 1 0.08 0.13 0.44
87 INT192342 Phosphorylation of PDGFRB 11 0.80 1.68 0.43
88 INT323752 Negative_regulation of FASLG 2 0.18 2.36 0.43
89 INT94173 Positive_regulation of CTSA 3 0.53 3.22 0.4
90 INT192344 Negative_regulation of Phosphorylation of PDGFRB 4 0.54 1.26 0.38
91 INT88021 Regulation of Gene_expression of Faslg 4 0.60 2.6 0.38
92 INT95132 Negative_regulation of Binding of FASLG 1 0.18 0.63 0.38
93 INT302663 Positive_regulation of ARSA 1 0.10 0.36 0.38
94 INT55784 Negative_regulation of Neu1 4 0.24 1.93 0.33
95 INT312038 Positive_regulation of Gene_expression of CTSA 1 0.04 0.72 0.32
96 INT312033 Transcription of CTSA 1 0.05 0.72 0.32
97 INT204930 Gene_expression of LGMN 1 0.07 0.48 0.31
98 INT173329 Protein_catabolism of SMPD1 1 0.13 0 0.31
99 INT11647 Regulation of GC 5 0.60 2.12 0.3
100 INT192348 Positive_regulation of Gene_expression of PDGFRB 5 0.64 3.57 0.3
101 INT83288 Negative_regulation of NEU4 12 0.51 3.58 0.28
102 INT287721 Regulation of Plbd2 1 0.01 0 0.27
103 INT78047 Negative_regulation of GLB1 2 0.51 1.3 0.25
104 INT74441 Positive_regulation of Negative_regulation of GLA 1 0.50 1.33 0.25
105 INT279296 Localization of PDGFRB 4 0.54 2.71 0.24
106 INT210070 Localization of GLA 1 0.70 1.96 0.24
107 INT3525 Protein_catabolism of NEU1 2 0.58 0.62 0.23
108 INT88018 Positive_regulation of Positive_regulation of Faslg 1 0.47 0.75 0.23
109 INT117050 Binding of GLA 8 0.47 2.41 0.22
110 INT45210 Regulation of Localization of NEU1 1 0.06 0.15 0.22
111 INT94547 Localization of Faslg 1 0.76 0.71 0.21
112 INT46296 Regulation of Negative_regulation of CTSA 1 0.40 0.17 0.17
113 INT171035 Binding of SMPD1 1 0.06 1.57 0.17
114 INT102892 Localization of CTSA 1 0.14 0 0.16
115 INT46192 Gene_expression of Neu1 1 0.03 0.42 0.16
116 INT46193 Positive_regulation of Gene_expression of Neu1 1 0.02 0.42 0.16
117 INT182865 Localization of ARSA 1 0.24 1.27 0.15
118 INT192339 Positive_regulation of Positive_regulation of PDGFRB 2 0.46 1.02 0.14
119 INT173347 Regulation of Gene_expression of SMPD1 1 0.07 0.48 0.14
120 INT186197 Gene_expression of SCARB2 7 0.40 2.93 0.13
121 INT57561 Regulation of Gene_expression of GLA 2 0.60 0.49 0.13
122 INT352180 Negative_regulation of Gene_expression of GLA 1 0.42 1.06 0.13
123 INT101932 Negative_regulation of Gene_expression of TPP1 1 0.40 0.53 0.12
124 INT210059 Negative_regulation of Localization of GLA 1 0.40 0.77 0.12
125 INT113367 Positive_regulation of Binding of GC 1 0.05 1 0.12
126 INT221134 Positive_regulation of NEU1 1 0.19 2.51 0.11
127 INT94176 Negative_regulation of NEU1 1 0.11 1.09 0.11
128 INT84944 Regulation of Negative_regulation of GC 1 0.44 1 0.1
129 INT57210 Positive_regulation of Regulation of GLB1 1 0.05 0.63 0.1
130 INT57211 Regulation of GLB1 1 0.07 0.63 0.1
131 INT20232 Negative_regulation of Negative_regulation of SMPD1 1 0.37 0.55 0.1
132 INT97861 Negative_regulation of Gene_expression of CTSA 3 0.13 1.11 0.09
133 INT287722 Negative_regulation of Gene_expression of Plbd2 1 0.02 0 0.09
134 INT192341 Negative_regulation of Gene_expression of PDGFRB 3 0.40 0.85 0.08
135 INT155113 Positive_regulation of Gene_expression of NEU1 1 0.29 0.45 0.08
136 INT163475 Binding of GM2A 1 0.28 0.3 0.08
137 INT192338 Positive_regulation of Phosphorylation of PDGFRB 4 0.45 0.48 0.07
138 INT94177 Positive_regulation of Positive_regulation of CTSA 1 0.38 0.76 0.06
139 INT160942 Negative_regulation of Negative_regulation of GLA 1 0.41 0.39 0.06
140 INT221135 Regulation of Binding of NEU1 1 0.17 0.61 0.06
141 INT250476 Negative_regulation of Transcription of FASLG 1 0.22 0.76 0.06
142 INT223616 Binding of PDGFRB 3 0.32 2.33 0.05
143 INT14443 Binding of GLB1 2 0.36 0.09 0.05
144 INT186202 Binding of SCARB2 1 0.19 0.58 0.05
145 INT287719 Binding of Plbd2 1 0.02 0 0.05
146 INT186200 Negative_regulation of Gene_expression of SCARB2 2 0.22 1.02 0.04
147 INT186194 Protein_catabolism of SCARB2 1 0.34 0.5 0.04
148 INT186193 Negative_regulation of Protein_catabolism of SCARB2 1 0.22 0.5 0.04
149 INT192340 Regulation of PDGFRB 4 0.45 3.83 0.03
150 INT210071 Positive_regulation of Transcription of GLA 2 0.54 0.67 0.03
151 INT210062 Transcription of GLA 2 0.56 0.67 0.03
152 INT226091 Negative_regulation of Binding of GC 1 0.02 0.29 0.03
153 INT279297 Positive_regulation of Localization of PDGFRB 1 0.36 0.5 0.03
154 INT287720 Regulation of Gene_expression of Plbd2 1 0.02 0 0.03
155 INT245940 Regulation of Positive_regulation of GLA 1 0.11 0.4 0.03
156 INT204931 Binding of LGMN 2 0.27 1.64 0
157 INT336195 Negative_regulation of Negative_regulation of PDGFRB 1 0.03 0.19 0
158 INT354644 Gene_expression of CUBN 1 0.65 0.32 0
159 INT300175 Positive_regulation of NEU4 1 0.01 0.48 0
160 INT210195 Regulation of Transcription of FASLG 1 0.08 0 0
161 INT338265 Positive_regulation of Binding of PDGFRB 1 0.25 1.38 0
162 INT241801 Binding of CTSA 1 0.13 0.15 0
163 INT129970 Negative_regulation of Binding of GLA 1 0.41 0.41 0
164 INT328279 Positive_regulation of Regulation of PDGFRB 1 0.37 0.74 0
165 INT200104 Regulation of Gene_expression of PDGFRB 1 0.18 0.29 0
166 INT300176 Localization of NEU4 1 0.01 0.47 0
167 INT292121 Regulation of Regulation of PDGFRB 1 0.22 0.93 0
168 INT259709 Negative_regulation of SCARB2 1 0.03 1.2 0
169 INT247407 Gene_expression of NEU4 1 0.20 0.22 0
170 INT83289 Binding of NEU4 1 0.02 0.1 0
171 INT300168 Binding of Neu1 1 0.07 0.27 0
172 INT292128 Positive_regulation of Negative_regulation of PDGFRB 1 0.25 1.08 0
173 INT186203 Transcription of SCARB2 1 0.36 0.57 0
174 INT345468 Localization of SCARB2 1 0.73 0 0
175 INT352685 Positive_regulation of Gene_expression of SCARB2 1 0.11 0.51 0
176 INT113297 Positive_regulation of Neu1 1 0.00 0.67 0
177 INT345466 Positive_regulation of Localization of SCARB2 1 0.49 0 0
178 INT328277 Negative_regulation of Positive_regulation of PDGFRB 1 0.36 1.64 0
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