GO:0043227

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Name membrane-bounded organelle
Categary Component
Go Slim No
Go Link GO:0043227
Unique Molecular Interactions 95
Total Molecular Interactions 117
Total Single Events 1659
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for membrane-bounded organelle. They are ordered first by their pain relevance and then by number of times they were reported for membrane-bounded organelle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
2 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
3 INT261372 Gsk3b Regulation of Gene_expression of Ifi205 1 0.00 0.24 0.58
4 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
5 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
6 INT288545 Gsk3b Negative_regulation of gr 1 0.25 0.38 0.38
7 INT152453 Gsk3b Regulation of Nfkb1 1 0.02 1.68 0.36
8 INT66369 Pomc Regulation of Positive_regulation of Gsk3b 1 0.07 0 0.35
9 INT321366 Gsk3b Regulation of Gene_expression of CYP8B1 1 0.01 0.21 0.33
10 INT342810 Binding of Adarb1 and Gsk3b 1 0.00 0.36 0.3
11 INT325530 Positive_regulation of Gsk3b Negative_regulation of Gene_expression of Wnt2 1 0.03 0.63 0.28
12 INT312894 Binding of Gsk3b and Positive_regulation of Gene_expression of Hdac6 1 0.08 1.3 0.27
13 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
14 INT270433 PLAT Positive_regulation of Positive_regulation of Gsk3b 1 0.04 0.5 0.21
15 INT261401 Binding of Gsk3b and ADHD1 1 0.00 1.62 0.18
16 INT312893 Gsk3b Positive_regulation of Hdac6 1 0.07 0.65 0.13
17 INT263320 Gsk3b Regulation of Uts2r 1 0.02 0.68 0.13
18 INT263318 Akt1 Regulation of Gsk3b 1 0.02 0.75 0.13
19 INT354327 Gsk3b Positive_regulation of Gene_expression of Ide 1 0.17 0.33 0.13
20 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
21 INT268634 Ptpn2 Positive_regulation of Positive_regulation of Gsk3b 1 0.02 1.08 0.11
22 INT289768 Akt1 Regulation of Phosphorylation of Gsk3b 1 0.04 0.45 0.11
23 INT268626 Mpz Positive_regulation of Positive_regulation of Gsk3b 1 0.29 1.08 0.11
24 INT198525 Binding of Kif5b and Ranbp2 1 0.23 0 0.1
25 INT32546 Gsk3b Negative_regulation of Localization of Gnrh1 1 0.05 0 0.1
26 INT32547 Gsk3b Negative_regulation of Localization of LH 1 0.04 0 0.1
27 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
28 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
29 INT268627 Ptpn2 Positive_regulation of Gsk3b 1 0.02 1.7 0.08
30 INT268630 Mpz Positive_regulation of Regulation of Gsk3b 1 0.18 0.57 0.07
31 INT354328 Gsk3b Regulation of Gs 1 0.16 0.84 0.07
32 INT354329 Gsk3b Regulation of Gene_expression of Gs 1 0.16 0.84 0.07
33 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
34 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
35 INT221235 Akt1 Negative_regulation of Gsk3b 1 0.06 0.14 0.06
36 INT193966 AKT1 Negative_regulation of Gsk3b 1 0.05 0.75 0.05
37 INT193969 AKT1 Negative_regulation of Phosphorylation of Gsk3b 1 0.05 0.75 0.05
38 INT181814 Gsk3b Regulation of Gata4 1 0.06 0.37 0.05
39 INT193967 Binding of PSEN1 and Psen1 1 0.41 1.2 0.05
40 INT193970 Binding of PSEN1 and Psen2 1 0.36 2.06 0.05
41 INT193964 Mapk1 Negative_regulation of Gsk3b 1 0.00 0.74 0.05
42 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
43 INT290810 Gsk3b Regulation of Arntl 1 0.15 0 0.04
44 INT331477 PSEN2 Regulation of Gene_expression of Psen1 1 0.00 0.15 0.03
45 INT303092 Gsk3b Positive_regulation of NEUROG2 1 0.01 0.16 0.03
46 INT290808 Gsk3b Positive_regulation of Arntl 1 0.25 0.17 0.03
47 INT234981 Binding of Dsg3 and Negative_regulation of Gsk3b 1 0.07 0.3 0.03
48 INT303083 Rorb Regulation of Gsk3b 1 0.00 0.52 0.03
49 INT331478 Psen1 Regulation of Gene_expression of PSEN2 1 0.00 0.15 0.03
50 INT268629 Mpz Regulation of Phosphorylation of Gsk3b 1 0.26 1.05 0.03
51 INT303079 Gsk3b Positive_regulation of Cebpg 1 0.08 0.16 0.03
52 INT265906 IGF1 Regulation of Gsk3b 1 0.25 1.31 0.03
53 INT337811 Gene_expression of Gsk3b Positive_regulation of Phosphorylation of Akt1 1 0.37 0.37 0.03
54 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
55 INT290811 Binding of Mgst1 and Gsk3b 1 0.05 0 0
56 INT290807 Positive_regulation of Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.14 0 0
57 INT193962 Binding of Psen1 and Ncstn 1 0.13 0.08 0
58 INT334644 Binding of PSEN1 and TTN 1 0.01 0 0
59 INT268628 Mpz Positive_regulation of Phosphorylation of Gsk3b 1 0.25 0.43 0
60 INT268635 Mpz Positive_regulation of Gsk3b 1 0.17 0.43 0
61 INT290809 Binding of Arntl and Gsk3b 1 0.20 0 0
62 INT193955 Binding of Psen1 and Psen2 1 0.37 1.64 0
63 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0
64 INT286331 Binding of Psen1 and Ror1 1 0.27 0 0
65 INT193968 Binding of PSEN1 and Ps 1 0.07 0.66 0
66 INT235077 Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.07 0.53 0
67 INT262712 Psen1 Regulation of Gene_expression of Bace1 1 0.22 0.07 0
68 INT217400 Binding of Psen1 and Bace1 1 0.17 1.43 0
69 INT286337 PSENEN Regulation of Psen1 1 0.07 0.37 0
70 INT193958 Binding of Pld1 and Psen1 1 0.17 0 0
71 INT193953 Binding of Bcl2l1 and Psen1 1 0.07 0.66 0
72 INT193956 Binding of Psen1 and Rab6a 1 0.15 0 0
73 INT281610 Positive_regulation of Akt1 Positive_regulation of Gsk3b 1 0.02 0.12 0
74 INT331479 Binding of PSEN2 and Psen1 1 0.00 0.07 0
75 INT230713 Binding of Prkcd and Gsk3b 1 0.34 0 0
76 INT268632 Mpz Regulation of Gsk3b 1 0.22 0 0
77 INT234221 Negative_regulation of PSEN1 Negative_regulation of Gene_expression of APP 1 0.33 0.32 0
78 INT290806 Gene_expression of Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.14 0 0
79 INT303004 Adm Positive_regulation of Gsk3b 1 0.04 0.97 0
80 INT263319 Binding of Gsk3b and Uts2r 1 0.01 0 0
81 INT334645 Binding of PSEN1 and HM13 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for membrane-bounded organelle. They are ordered first by their pain relevance and then by number of times they were reported in membrane-bounded organelle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
2 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
3 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
4 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28
5 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
6 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
7 INT124370 Positive_regulation of Gene_expression of Gsk3b 47 0.67 24.56 5.4
8 INT135374 Binding of Gsk3b 46 0.48 24.36 4.75
9 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27
10 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21
11 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
12 INT116642 Negative_regulation of Gsk3b 13 0.57 7.16 3.83
13 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53
14 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
15 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07
16 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
17 INT163544 Binding of Psen1 40 0.36 15.28 2.42
18 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
19 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
20 INT204018 Localization of Gsk3b 27 0.71 13.67 1.87
21 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
22 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
23 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
24 INT167283 Negative_regulation of Phosphorylation of Gsk3b 12 0.59 7.94 1.16
25 INT134036 Regulation of Gsk3b 4 0.60 1.42 1.15
26 INT32545 Localization of Gsk3b 9 0.07 2.88 1.11
27 INT208536 Positive_regulation of Positive_regulation of Gsk3b 6 0.30 4.83 1.11
28 INT116646 Regulation of Negative_regulation of Gsk3b 2 0.44 0.39 0.99
29 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
30 INT261360 Binding of Gsk3b 5 0.36 2.85 0.9
31 INT167285 Positive_regulation of Phosphorylation of Gsk3b 17 0.50 5.92 0.82
32 INT156945 Positive_regulation of Negative_regulation of Gsk3b 6 0.38 4.58 0.82
33 INT66365 Positive_regulation of Gene_expression of Gsk3b 2 0.07 0.95 0.81
34 INT237406 Positive_regulation of Binding of Psen1 1 0.29 0 0.8
35 INT116644 Phosphorylation of Gsk3b 4 0.61 0.68 0.78
36 INT204002 Negative_regulation of Gene_expression of Gsk3b 15 0.55 8.57 0.77
37 INT286313 Transcription of Psen1 9 0.70 2.26 0.76
38 INT242137 Negative_regulation of Positive_regulation of Gsk3b 7 0.39 2.99 0.67
39 INT204006 Negative_regulation of Localization of Gsk3b 6 0.40 1.66 0.6
40 INT230679 Positive_regulation of Binding of Gsk3b 3 0.42 1.42 0.58
41 INT217394 Regulation of Binding of PSEN1 1 0.44 1.58 0.53
42 INT208537 Regulation of Gene_expression of Gsk3b 4 0.36 2.15 0.52
43 INT234249 Regulation of PSEN1 6 0.37 2.21 0.43
44 INT288540 Negative_regulation of Binding of Gsk3b 4 0.53 2.12 0.43
45 INT208552 Negative_regulation of Negative_regulation of Gsk3b 3 0.31 1.8 0.43
46 INT234257 Regulation of Gene_expression of PSEN1 6 0.44 1.98 0.42
47 INT235064 Regulation of Positive_regulation of Gsk3b 3 0.41 1.5 0.42
48 INT193856 Localization of Psen1 19 0.73 9.79 0.41
49 INT204012 Regulation of Negative_regulation of Gsk3b 4 0.42 4.51 0.39
50 INT208538 Regulation of Phosphorylation of Gsk3b 3 0.49 4.49 0.38
51 INT177773 Localization of PSEN1 4 0.73 0.89 0.36
52 INT66364 Regulation of Positive_regulation of Gsk3b 1 0.07 0 0.35
53 INT268620 Regulation of Localization of Gsk3b 3 0.35 2.12 0.28
54 INT316045 Negative_regulation of Negative_regulation of Psen1 1 0.42 1.58 0.27
55 INT261676 Negative_regulation of Positive_regulation of PSEN1 1 0.36 1.59 0.25
56 INT345254 Positive_regulation of Localization of Gsk3b 2 0.01 0.91 0.24
57 INT204021 Transcription of Gsk3b 8 0.57 2.75 0.23
58 INT268621 Positive_regulation of Localization of Gsk3b 4 0.40 1.54 0.22
59 INT116647 Positive_regulation of Phosphorylation of Gsk3b 1 0.37 0.18 0.22
60 INT181508 Regulation of Regulation of Psen1 2 0.33 0.51 0.2
61 INT286317 Positive_regulation of Transcription of Psen1 1 0.37 0.32 0.17
62 INT336359 Positive_regulation of Phosphorylation of Psen1 1 0.33 0.4 0.13
63 INT336361 Phosphorylation of Psen1 1 0.54 0.34 0.13
64 INT268617 Negative_regulation of Regulation of Gsk3b 3 0.28 1.84 0.11
65 INT201694 Negative_regulation of Gene_expression of PSEN1 3 0.41 2.31 0.1
66 INT309869 Regulation of Binding of Gsk3b 1 0.12 0.66 0.1
67 INT312871 Positive_regulation of Transcription of Gsk3b 2 0.29 0.15 0.09
68 INT273285 Negative_regulation of Localization of Psen1 1 0.36 0.99 0.09
69 INT193862 Positive_regulation of Positive_regulation of Psen1 3 0.49 0.9 0.08
70 INT193872 Positive_regulation of Localization of Psen1 3 0.49 1.39 0.08
71 INT234926 Protein_catabolism of Gsk3b 2 0.58 1.33 0.08
72 INT234906 Positive_regulation of Protein_catabolism of Gsk3b 2 0.33 1.33 0.08
73 INT261678 Positive_regulation of Positive_regulation of PSEN1 1 0.42 0.62 0.08
74 INT193890 Regulation of Positive_regulation of Psen1 1 0.44 0.66 0.08
75 INT193938 Phosphorylation of PSEN1 5 0.79 1.6 0.07
76 INT193859 Negative_regulation of Binding of Psen1 3 0.42 1.85 0.05
77 INT331406 Negative_regulation of Regulation of Psen1 1 0.04 0.09 0.05
78 INT193865 Protein_catabolism of Psen1 10 0.97 0.37 0.04
79 INT336062 Regulation of Localization of Gsk3b 1 0.03 0.48 0.04
80 INT268625 Regulation of Transcription of Gsk3b 2 0.15 0 0
81 INT286327 Regulation of Binding of Psen1 1 0.33 0.16 0
82 INT234250 Positive_regulation of Negative_regulation of PSEN1 1 0.41 0 0
83 INT193886 Regulation of Protein_catabolism of Psen1 1 0.44 0.06 0
84 INT193934 Positive_regulation of Binding of PSEN1 1 0.49 0.92 0
85 INT331407 Negative_regulation of Transcription of Psen1 1 0.04 0.08 0
86 INT177774 Transcription of PSEN1 1 0.33 0.09 0
87 INT268441 Regulation of Regulation of Gsk3b 1 0.07 0.72 0
88 INT260480 Transcription of Gsk3b 1 0.02 3.08 0
89 INT152449 Regulation of Protein_catabolism of Gsk3b 1 0.12 0.49 0
90 INT193844 Positive_regulation of Protein_catabolism of Psen1 1 0.49 0.05 0
91 INT152451 Regulation of Gene_expression of Gsk3b 1 0.12 0.57 0
92 INT234258 Negative_regulation of Phosphorylation of PSEN1 1 0.35 0.49 0
93 INT152448 Protein_catabolism of Gsk3b 1 0.28 0.49 0
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