GO:0043231

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Name intracellular membrane-bounded organelle
Categary Component
Go Slim No
Go Link GO:0043231
Unique Molecular Interactions 1476
Total Molecular Interactions 2101
Total Single Events 18273
Pain Genes Associated 176

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for intracellular membrane-bounded organelle. They are ordered first by their pain relevance and then by number of times they were reported for intracellular membrane-bounded organelle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62
2 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 0.10 2.91 6.54
3 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09
4 INT140935 Binding of Cd40lg and Cd40 1 0.30 6.34 5.61
5 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01
6 INT150457 Binding of Sort1 and Prss12 3 0.21 1.36 2.64
7 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
8 INT81657 Binding of CPOX and PTGS1 5 0.15 1.9 2.37
9 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21
10 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14
11 INT135868 Zfp821 Positive_regulation of Binding of ACAA1 1 0.00 0 2.11
12 INT60867 Binding of G2e3 and Gpm6a 2 0.01 0.1 1.93
13 INT68272 Binding of Oprd1 and G2e3 1 0.00 0.11 1.93
14 INT305741 Binding of Kcnk2 and Sort1 1 0.54 1.01 1.8
15 INT150456 Binding of Sort1 and Nts 3 0.45 0.64 1.79
16 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
17 INT119918 Zfp821 Positive_regulation of Binding of ACAA1 1 0.00 0 1.64
18 INT73116 TYMS Negative_regulation of DNMT3B 1 0.24 0 1.6
19 INT73115 TYMS Negative_regulation of Positive_regulation of DNMT3B 1 0.24 0 1.6
20 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
21 INT298283 Pou4f1 Positive_regulation of Gene_expression of Runx1 1 0.50 1.4 1.48
22 INT172203 Binding of Comt and Maoa 1 0.31 0.98 1.43
23 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42
24 INT139768 Binding of TRPV1 and ICK 1 0.41 1.59 1.42
25 INT202910 Uchl1 Positive_regulation of Gene_expression of Tacr1 1 0.05 1.65 1.42
26 INT139767 ICK Regulation of TRPV1 1 0.30 1.59 1.42
27 INT202912 Uchl1 Positive_regulation of Gene_expression of Ntrk2 1 0.08 1.64 1.42
28 INT128913 Binding of COMT and PENK 1 0.30 0.07 1.41
29 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
30 INT116827 Binding of UCHL1 and TRPV1 1 0.41 0.88 1.39
31 INT168865 Cd38 Regulation of Wdtc1 1 0.03 0.12 1.35
32 INT115272 Neu1 Positive_regulation of Coq10a 1 0.43 0.41 1.35
33 INT115271 Neu1 Positive_regulation of Coq10a 1 0.01 0.41 1.35
34 INT265213 Binding of Ctla4 and Cd86 2 0.13 1.93 1.31
35 INT132412 Negative_regulation of Ngf Negative_regulation of Ptgs1 1 0.01 0.81 1.31
36 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
37 INT192080 Foxm1 Positive_regulation of Cnr1 2 0.14 0.72 1.3
38 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29
39 INT18659 Plat Regulation of ZC3H12D 1 0.02 0.1 1.29
40 INT105295 WAS Regulation of PTGS1 1 0.02 0.13 1.27
41 INT162165 WDTC1 Positive_regulation of PLD2 1 0.50 0 1.25
42 INT202036 CAMK2N2 Negative_regulation of MMP3 1 0.00 0.73 1.24
43 INT103031 Calca Positive_regulation of Ptgs1 2 0.46 0.98 1.22
44 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
45 INT261617 SNRNP70 Regulation of Comt 1 0.01 0.4 1.18
46 INT111221 MMEL1 Negative_regulation of HMOX1 1 0.01 1 1.16
47 INT298272 Runx1 Positive_regulation of Gene_expression of Ntrk3 1 0.52 0.88 1.09
48 INT305734 Binding of Sort1 and Trpv1 1 0.01 0.5 1.08
49 INT168529 APP Regulation of FSIP1 2 0.65 2.26 1.07
50 INT239038 Negative_regulation of Binding of Cd28 and Cd86 3 0.17 1.5 1.05
51 INT131853 CD40 Negative_regulation of Gene_expression of CD40LG 1 0.09 1.54 1.05
52 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03
53 INT153039 Binding of G2e3 and LOC100360318 1 0.00 0 1.01
54 INT298298 Calca Negative_regulation of Gene_expression of Runx1 1 0.19 0.33 1
55 INT298274 Gene_expression of Runx1 Negative_regulation of Calca 1 0.19 0.33 1
56 INT140934 Binding of Cd40 and Ean5 1 0.09 1.03 0.98
57 INT60213 Binding of Ptgs1 and Ptgs2 2 0.37 0.5 0.97
58 INT286798 Binding of Il6st and Cntf 1 0.10 1.34 0.97
59 INT219279 Ctss Positive_regulation of Gene_expression of Fam64a 1 0.06 1.39 0.96
60 INT219273 Fam64a Positive_regulation of Gene_expression of Ctss 1 0.06 1.39 0.96
61 INT61037 Och Positive_regulation of Ptgs1 1 0.00 0 0.95
62 INT351311 Has1 Regulation of Gene_expression of MMP3 1 0.11 1.15 0.95
63 INT149390 Foxm1 Positive_regulation of Trpa1 1 0.28 0.31 0.94
64 INT265649 TBK1 Negative_regulation of COMT 1 0.01 0.61 0.94
65 INT216736 Binding of ADORA2B and ATP6V0A1 2 0.08 0.06 0.93
66 INT153685 Binding of Bcl2l11 and Gtpbp4 1 0.08 0.76 0.93
67 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93
68 INT155259 RUNX1 Negative_regulation of Tnf 1 0.00 1.48 0.93
69 INT159996 Prkcg Regulation of Gene_expression of App 1 0.42 0.32 0.92
70 INT159993 App Regulation of Gene_expression of Bace1 1 0.46 0.32 0.92
71 INT159994 App Regulation of Gene_expression of Prkcg 1 0.42 0.32 0.92
72 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
73 INT63488 Sptan1 Positive_regulation of Rtcd1 1 0.03 0.34 0.91
74 INT119100 Positive_regulation of F2rl1 Positive_regulation of Positive_regulation of Ptgs1 1 0.03 0.56 0.9
75 INT52759 Oprd1 Regulation of Sptan1 1 0.03 0 0.9
76 INT121704 HRAS Negative_regulation of MMP3 1 0.06 0.19 0.89
77 INT52761 Dll1 Regulation of Sptan1 1 0.07 0 0.89
78 INT272144 PTAFR Positive_regulation of HRASLS 1 0.08 1.08 0.89
79 INT165627 Binding of COMT and SLTM 1 0.09 0.86 0.88
80 INT61698 G2e3 Regulation of Localization of Abat 1 0.05 0 0.88
81 INT326455 Runx1 Positive_regulation of Gene_expression of Trpv1 1 0.45 0 0.88
82 INT305742 Binding of Sort1 and Gtf3a 1 0.01 0.64 0.88
83 INT121467 Binding of Avp and Ptafr 1 0.11 0.98 0.88
84 INT298289 Runx1 Negative_regulation of Ntrk2 1 0.60 1.09 0.87
85 INT298295 Runx1 Negative_regulation of Gene_expression of Ntrk1 2 0.38 0.45 0.86
86 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
87 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
88 INT260894 CRH Regulation of Localization of MMP3 1 0.21 0.36 0.85
89 INT342986 PTAFR Positive_regulation of Gene_expression of IL6 1 0.14 0.39 0.84
90 INT282506 ocd Positive_regulation of Gene_expression of Comt 1 0.32 1.26 0.84
91 INT340115 Comt Regulation of Localization of Dusp1 1 0.12 0.83 0.83
92 INT167431 Binding of APP and MYO1C 1 0.23 1.38 0.83
93 INT116108 VEGFA Positive_regulation of SEC23IP 1 0.10 0.3 0.83
94 INT340114 Comt Regulation of Localization of Pain1 1 0.02 0.83 0.83
95 INT340113 Comt Regulation of Bdnf 1 0.21 0.74 0.82
96 INT201241 Positive_regulation of GDI2 Positive_regulation of Regulation of AGFG1 1 0.01 0 0.82
97 INT62176 Binding of PTGS2 and Ptgs1 2 0.00 0.69 0.79
98 INT107917 RETNLB Positive_regulation of Gene_expression of App 1 0.01 1.2 0.79
99 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
100 INT16014 Ptafr Regulation of Ns5atp9 1 0.32 1.17 0.78
101 INT342992 Negative_regulation of PTAFR Negative_regulation of Gene_expression of HIST2H2AA3 1 0.01 0.4 0.78
102 INT308483 Paf Positive_regulation of Gene_expression of Ptafr 1 0.12 1.14 0.78
103 INT104749 Ugt1a1 Regulation of Positive_regulation of G2e3 1 0.00 0.07 0.77
104 INT34241 Dlst Positive_regulation of Positive_regulation of LH 1 0.28 0 0.77
105 INT136795 Spp1 Positive_regulation of Chuk 1 0.11 1.54 0.77
106 INT347368 RYBP Negative_regulation of GSTK1 1 0.00 0 0.77
107 INT308485 Paf Positive_regulation of Ptafr 1 0.12 1.13 0.77
108 INT334833 Binding of Drd2 and Ncs1 1 0.05 1.11 0.76
109 INT31776 Positive_regulation of Gclc Positive_regulation of G6pd 1 0.29 0.19 0.75
110 INT266100 Binding of COMT and SH2B2 1 0.25 1.22 0.74
111 INT327707 Binding of Comt and Drd1a 1 0.18 0.27 0.74
112 INT266108 Binding of COMT and HPS1 1 0.23 1.21 0.74
113 INT327702 Binding of Comt and Drd2 1 0.28 0.27 0.74
114 INT114281 Binding of Oprd1 and Nacc1 1 0.03 0 0.74
115 INT327712 Binding of Comt and Rbm39 1 0.00 0.27 0.74
116 INT119314 Ptgs1 Regulation of Gene_expression of Ptger2 1 0.01 0.6 0.73
117 INT287132 Binding of NT5E and Comt 1 0.03 0.11 0.73
118 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
119 INT101675 Bcl2l11 Regulation of Localization of Ggh 1 0.03 0 0.72
120 INT272147 PTAFR Positive_regulation of CA2 1 0.13 0 0.71
121 INT326457 Runx1 Regulation of Mrgpra3 1 0.37 0.1 0.71
122 INT326456 Runx1 Regulation of Pip4k2b 1 0.09 0.11 0.71
123 INT139069 Binding of CTLA4 and Cd86 3 0.16 0.65 0.7
124 INT261378 Nsdhl Negative_regulation of Gene_expression of Flvcr2 1 0.01 0.34 0.7
125 INT121697 IL4I1 Positive_regulation of Gene_expression of MMP3 1 0.06 0.27 0.7
126 INT99818 IFNG Positive_regulation of Gene_expression of APP 1 0.04 0.82 0.7
127 INT207540 Tfap2a Regulation of Oprm1 1 0.13 0.06 0.7
128 INT135207 Gmeb1 Regulation of Gene_expression of Tfap2a 1 0.07 0.48 0.69
129 INT135206 Ighen Regulation of Gene_expression of Tfap2a 1 0.06 0.48 0.69
130 INT114735 Mtx1 Regulation of Ptgs1 1 0.01 0.31 0.69
131 INT135202 Tfap2a Regulation of Gene_expression of Ighen 1 0.06 0.48 0.69
132 INT135213 Tfap2a Regulation of Gene_expression of Nfkb1 1 0.02 0.48 0.69
133 INT135211 Nfkb1 Regulation of Gene_expression of Tfap2a 1 0.02 0.48 0.69
134 INT135204 Tfap2a Regulation of Gene_expression of Gmeb1 1 0.10 0.48 0.69
135 INT68561 Binding of Gli3 and Ust 1 0.01 0.68 0.68
136 INT207543 Tfap2a Regulation of Qsox1 1 0.04 0.06 0.67
137 INT171825 Binding of Prkcg and Ncs1 1 0.00 0.07 0.66
138 INT171824 Binding of Ncs1 and Aspm 1 0.00 0.07 0.65
139 INT78663 Dlst Regulation of Nos1 1 0.19 0.91 0.65
140 INT137099 Dlst Regulation of Sec22b 1 0.05 0 0.64
141 INT137100 Dlst Regulation of Htr1a 1 0.18 0 0.64
142 INT206206 Binding of Mcf2l and Obfc1 1 0.02 1.11 0.64
143 INT299793 Positive_regulation of Binding of CD86 and CTLA4 1 0.17 1.64 0.63
144 INT2700 Binding of App and Cpe 1 0.00 0 0.63
145 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
146 INT139079 Tnip1 Negative_regulation of Ptch1 1 0.20 0.63 0.62
147 INT118083 Aip Negative_regulation of Phosphorylation of APP 1 0.00 0.75 0.62
148 INT326471 Binding of ATP6V0A1 and IGKV2D-29 1 0.00 0.09 0.62
149 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
150 INT231027 LOC100366054 Negative_regulation of Gene_expression of Pgr 1 0.02 0 0.62
151 INT101320 Negative_regulation of Ptgs1 Positive_regulation of Ptgs2 1 0.03 0.2 0.62
152 INT84771 Positive_regulation of Binding of App and Pag1 1 0.17 0.9 0.62
153 INT55672 Ptgs1 Positive_regulation of Gene_expression of Ik 1 0.03 0.75 0.61
154 INT95435 Il1a Positive_regulation of Positive_regulation of Mmp3 1 0.59 0.25 0.61
155 INT95436 Il1a Positive_regulation of Mmp3 1 0.59 0.25 0.61
156 INT92998 Positive_regulation of SFTPA1 Positive_regulation of Localization of CD40 1 0.15 0.34 0.61
157 INT95433 Mmp3 Regulation of Mmp2 1 0.17 0.24 0.6
158 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
159 INT342981 PTAFR Regulation of SFTPA1 1 0.03 0.38 0.6
160 INT95430 Mmp9 Positive_regulation of Mmp3 1 0.38 0.24 0.6
161 INT272146 PTAFR Positive_regulation of Localization of IL8 3 0.38 0.28 0.59
162 INT120203 Binding of App and Il1 1 0.17 1.28 0.59
163 INT120204 Binding of App and Il1f5 1 0.09 1.28 0.59
164 INT280895 Runx1 Positive_regulation of Gene_expression of Ret 2 0.33 0.2 0.58
165 INT287753 Lpar3 Positive_regulation of Gene_expression of Lpar1 1 0.46 0.39 0.58
166 INT287744 Lpar3 Positive_regulation of Positive_regulation of Lpar1 1 0.46 0.39 0.58
167 INT118001 Csk Regulation of Trpv1 1 0.08 0.09 0.58
168 INT302833 Gene_expression of Mir155 Negative_regulation of Gene_expression of Mmp3 1 0.03 1 0.57
169 INT34239 Dlst Regulation of Positive_regulation of LH 1 0.27 0 0.57
170 INT47284 Binding of Mme and Ctsa 1 0.21 0 0.57
171 INT84770 Binding of App and Pag1 1 0.13 0.89 0.57
172 INT92999 Binding of CD40 and VCAM1 1 0.39 0.33 0.57
173 INT222183 Binding of HDLBP and PLA2G15 1 0.01 0.7 0.57
174 INT347366 RYBP Regulation of Gene_expression of GSTK1 1 0.00 0 0.57
175 INT203105 MMP3 Negative_regulation of Gene_expression of IL10 1 0.06 0.69 0.56
176 INT173557 TIMP1 Negative_regulation of MMP3 1 0.02 0 0.56
177 INT298278 Runx1 Negative_regulation of Gene_expression of Ntrk2 1 0.44 0.8 0.56
178 INT167618 Rho Regulation of App 1 0.17 0.88 0.55
179 INT249624 Negative_regulation of Binding of CD86 and CTLA4 1 0.47 0.57 0.55
180 INT34242 Dlst Regulation of Localization of LH 1 0.43 0 0.55
181 INT167620 Rock2 Regulation of App 1 0.13 0.87 0.55
182 INT190702 CD40 Positive_regulation of Gene_expression of F3 1 0.00 1.4 0.55
183 INT114029 Binding of ALB and Mmp3 1 0.01 0.31 0.55
184 INT114028 Negative_regulation of Binding of ALB and Mmp3 1 0.01 0.31 0.55
185 INT267707 Binding of Tnf and ARID1B 2 0.20 8.2 0.54
186 INT248997 Gabrg1 Positive_regulation of Clock 1 0.37 0 0.54
187 INT248995 Gabrg1 Regulation of Transcription of Clock 1 0.36 0 0.54
188 INT76200 CASP1 Positive_regulation of Gene_expression of PTGS1 1 0.05 0.16 0.54
189 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
190 INT316738 Il1 Positive_regulation of Mmp3 1 0.02 0.63 0.54
191 INT204494 Binding of App and Fmr1 1 0.54 4.39 0.54
192 INT249016 Gabrg1 Positive_regulation of Transcription of Clock 1 0.37 0 0.54
193 INT310701 RPLP0 Regulation of Positive_regulation of PGR 1 0.01 0.49 0.53
194 INT291386 Cntf Regulation of Gene_expression of Gria2 1 0.11 0.13 0.53
195 INT13191 FPR1 Positive_regulation of Localization of GUSB 1 0.31 0 0.53
196 INT231034 Sec22b Positive_regulation of Gene_expression of Pgr 1 0.04 0.09 0.53
197 INT245553 Runx1 Positive_regulation of Gene_expression of Ntrk1 2 0.45 1.41 0.52
198 INT330544 Bcl2l11 Negative_regulation of Prkcg 1 0.03 0.38 0.52
199 INT330553 Bcl2l11 Negative_regulation of Camk2a 1 0.01 0.38 0.52
200 INT8438 Cntf Regulation of TAC1 1 0.20 0.18 0.52

Single Events

The table below shows the top 100 pain related interactions that have been reported for intracellular membrane-bounded organelle. They are ordered first by their pain relevance and then by number of times they were reported in intracellular membrane-bounded organelle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26
2 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6
3 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58
4 INT65500 Gene_expression of App 605 0.78 429.94 98.31
5 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97
6 INT133211 Gene_expression of Runx1 169 0.77 83.4 76.16
7 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5
8 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04
9 INT8465 Regulation of Ptgs1 100 0.57 36.03 44.41
10 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78
11 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49
12 INT29743 Negative_regulation of App 91 0.59 65.56 31.26
13 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18
14 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95
15 INT47712 Positive_regulation of App 135 0.69 101.38 28.94
16 INT10506 Gene_expression of PTAFR 86 0.76 37.57 28.58
17 INT101120 Gene_expression of Comt 63 0.77 34.75 26.13
18 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62
19 INT140193 Gene_expression of Mmp3 58 0.71 49.65 25.4
20 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31
21 INT93717 Gene_expression of Mmp3 85 0.78 33.95 24.89
22 INT44954 Gene_expression of APP 191 0.78 105.86 23.9
23 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5
24 INT21503 Binding of Ptgs1 45 0.48 15.6 22.29
25 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19
26 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7
27 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05
28 INT11625 Localization of App 98 0.78 55.46 20.86
29 INT45840 Positive_regulation of Gene_expression of Ptgs1 35 0.50 16.07 20.49
30 INT519 Negative_regulation of Comt 52 0.59 17.65 20.39
31 INT16794 Binding of App 103 0.48 64.87 19.79
32 INT65502 Regulation of App 77 0.62 52.05 19.44
33 INT135629 Binding of COMT 33 0.48 16.68 19.37
34 INT5160 Localization of PTAFR 61 0.80 42.6 19.16
35 INT16110 Positive_regulation of ZC3H12D 30 0.46 6.27 18.72
36 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86
37 INT96155 Gene_expression of Cd86 134 0.77 50.56 17.13
38 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68
39 INT9197 Binding of PTGS1 44 0.48 18.48 16.26
40 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17
41 INT81486 Localization of MMP3 31 0.81 12.94 15.21
42 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06
43 INT54052 Gene_expression of App 33 0.78 25.08 14.7
44 INT53080 Positive_regulation of Ptgs1 42 0.42 23.58 14.37
45 INT133156 Binding of Cd40 77 0.48 45.92 13.77
46 INT95427 Positive_regulation of Mmp3 39 0.70 15.28 13.36
47 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34
48 INT101147 Gene_expression of Uchl1 31 0.76 14.73 13.22
49 INT101119 Negative_regulation of Comt 19 0.58 8.77 13.09
50 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79
51 INT60865 Gene_expression of G2e3 20 0.73 2.1 12.76
52 INT29745 Binding of APP 47 0.48 26.49 12.4
53 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38
54 INT245517 Positive_regulation of Gene_expression of Runx1 49 0.69 17.7 12.38
55 INT17619 Regulation of COMT 12 0.45 8.46 12.22
56 INT520 Binding of Comt 24 0.48 8.98 12.21
57 INT92686 Gene_expression of Ctgf 51 0.77 34.4 11.93
58 INT133212 Negative_regulation of Runx1 21 0.58 11.16 11.89
59 INT12992 Negative_regulation of Gene_expression of Ptgs1 33 0.42 20.47 11.77
60 INT13303 Positive_regulation of PTAFR 40 0.69 16.27 11.56
61 INT20457 Regulation of Ptgs1 23 0.48 11.63 11.56
62 INT787 Localization of Ptgs1 31 0.80 12.36 11.55
63 INT148639 Gene_expression of Uchl1 30 0.59 16.76 11.54
64 INT58775 Binding of G2e3 10 0.33 0.19 11.52
65 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48
66 INT80756 Gene_expression of CD86 77 0.77 46.68 11.36
67 INT47702 Gene_expression of Sptan1 24 0.76 7.6 11.36
68 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15
69 INT133210 Positive_regulation of Runx1 33 0.69 18.25 10.12
70 INT149818 Gene_expression of Clock 81 0.70 14.15 10.04
71 INT245538 Negative_regulation of Gene_expression of Runx1 20 0.58 11.68 9.97
72 INT19620 Binding of CD86 30 0.47 12.01 9.89
73 INT102987 Regulation of MMP3 23 0.60 9.35 9.54
74 INT41569 Regulation of APP 32 0.62 17.15 9.4
75 INT130497 Gene_expression of Cbs 5 0.77 16.93 9.34
76 INT144736 Negative_regulation of Gene_expression of COMT 13 0.58 6.47 9.28
77 INT37896 Positive_regulation of Gene_expression of PTGS1 37 0.67 17.28 9.27
78 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25
79 INT12991 Negative_regulation of Gene_expression of PTGS1 28 0.41 13.39 8.9
80 INT23264 Negative_regulation of Positive_regulation of Ptgs1 16 0.39 8.47 8.9
81 INT122952 Positive_regulation of COMT 13 0.50 8.1 8.89
82 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85
83 INT52442 Binding of Ptgs1 16 0.35 9.05 8.78
84 INT6573 Regulation of Negative_regulation of Ptgs1 19 0.45 6.16 8.71
85 INT8423 Gene_expression of Cntf 29 0.69 11.69 8.4
86 INT30526 Negative_regulation of PTAFR 15 0.58 8.15 8.19
87 INT308473 Positive_regulation of Ptafr 1 0.58 13.26 7.92
88 INT113671 Negative_regulation of Mmp3 26 0.49 6.33 7.88
89 INT32454 Gene_expression of Ptafr 3 0.65 15.19 7.87
90 INT44537 Positive_regulation of Comt 7 0.69 2.62 7.78
91 INT58774 Negative_regulation of G2e3 8 0.38 0.22 7.75
92 INT20234 Regulation of Gene_expression of Ptgs1 11 0.44 6.55 7.72
93 INT5409 Negative_regulation of G6pd 33 0.57 29.21 7.64
94 INT56031 Positive_regulation of App 25 0.69 13.46 7.37
95 INT261511 Localization of CBS 1 0.02 5.06 7.27
96 INT49751 Negative_regulation of Positive_regulation of PTGS1 12 0.45 4.73 7.23
97 INT101121 Regulation of Comt 19 0.53 10.66 7.22
98 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2
99 INT43727 Negative_regulation of Gene_expression of MMP3 16 0.40 4.81 7.18
100 INT78199 Gene_expression of Neu1 65 0.75 62.88 7.16
101 INT93003 Binding of CD40 28 0.47 20.25 7.13
102 INT55957 Positive_regulation of PRNP 57 0.67 37.87 7.11
103 INT7607 Localization of Nacc1 7 0.81 0 7.09
104 INT144739 Regulation of Gene_expression of COMT 11 0.61 3.07 7.08
105 INT168381 Positive_regulation of Mmp3 24 0.58 19.12 7.03
106 INT159518 Gene_expression of Clock 4 0.35 2.34 6.91
107 INT10505 Gene_expression of Ptafr 18 0.62 10.7 6.83
108 INT11150 Positive_regulation of Dlst 31 0.51 9.01 6.63
109 INT10507 Positive_regulation of Gene_expression of PTAFR 15 0.61 10.24 6.61
110 INT96218 Positive_regulation of Pgr 17 0.68 5.23 6.57
111 INT185691 Positive_regulation of WDTC1 24 0.48 12.57 6.49
112 INT50337 Negative_regulation of Foxm1 24 0.43 11.12 6.48
113 INT68304 Positive_regulation of Nacc1 11 0.70 0.76 6.45
114 INT150825 Binding of Comt 13 0.42 6.65 6.42
115 INT170385 Regulation of Clock 29 0.49 4.95 6.39
116 INT25130 Positive_regulation of Negative_regulation of Ptgs1 14 0.50 5.07 6.29
117 INT169596 Transcription of Runx1 12 0.71 5.55 6.27
118 INT48234 Negative_regulation of Gene_expression of PTAFR 11 0.57 3.97 6.25
119 INT50712 Gene_expression of Comt 13 0.68 6.33 6.23
120 INT245515 Regulation of Runx1 14 0.61 5.07 6.22
121 INT181017 Gene_expression of Ctss 6 0.65 9.82 6.19
122 INT17370 Negative_regulation of Negative_regulation of Ptgs1 16 0.22 6.5 6.12
123 INT140503 Negative_regulation of Gene_expression of Mmp3 7 0.44 5.93 6.08
124 INT48004 Positive_regulation of Negative_regulation of PTGS1 12 0.49 4.07 5.87
125 INT113700 Positive_regulation of Chuk 30 0.41 21.17 5.69
126 INT3731 Negative_regulation of Neu1 17 0.39 8.35 5.67
127 INT104673 Positive_regulation of Obfc1 10 0.41 4.26 5.61
128 INT55513 Binding of Foxm1 19 0.37 2.37 5.54
129 INT5156 Regulation of ZC3H12D 7 0.27 2.64 5.53
130 INT142607 Positive_regulation of Gene_expression of Cd40 41 0.62 13.85 5.51
131 INT69572 Localization of Prnp 96 0.81 38.11 5.45
132 INT35928 Positive_regulation of Baat 12 0.69 12.23 5.43
133 INT50491 Regulation of Gene_expression of PTGS1 17 0.47 6 5.4
134 INT138157 Regulation of Mmp3 12 0.54 6.12 5.36
135 INT59891 Positive_regulation of GSTK1 46 0.67 17.66 5.33
136 INT73117 Positive_regulation of DNMT3B 20 0.47 10.31 5.31
137 INT107173 Phosphorylation of App 20 0.82 12.64 5.3
138 INT12854 Negative_regulation of Gusb 11 0.42 3.25 5.28
139 INT2162 Regulation of Comt 13 0.60 2.9 5.18
140 INT92330 Gene_expression of WDTC1 22 0.47 13.12 5.15
141 INT5411 Positive_regulation of G6pd 20 0.70 4.74 5.11
142 INT107242 Binding of MMP3 14 0.47 12.06 5.11
143 INT86475 Binding of ACAA1 7 0.28 1.83 5.11
144 INT39256 Localization of PTGS1 17 0.74 6.62 5.1
145 INT99823 Positive_regulation of Gene_expression of APP 31 0.70 21.52 5.09
146 INT83735 Gene_expression of Foxm1 41 0.77 22.9 5.07
147 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06
148 INT216754 Binding of ATP6V0A1 5 0.11 0.71 4.98
149 INT86219 Negative_regulation of GSTK1 25 0.41 8.99 4.97
150 INT62675 Gene_expression of Nacc1 7 0.78 0.26 4.94
151 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93
152 INT201653 Gene_expression of Sort1 6 0.75 6.29 4.89
153 INT245536 Regulation of Gene_expression of Runx1 11 0.58 6.22 4.88
154 INT131692 Negative_regulation of Localization of App 9 0.53 4.69 4.82
155 INT102254 Positive_regulation of Gene_expression of Prnp 72 0.70 38.11 4.81
156 INT2871 Positive_regulation of Comt 9 0.50 2.8 4.78
157 INT308479 Transcription of Ptafr 1 0.60 10.05 4.76
158 INT102237 Positive_regulation of Gene_expression of MMP3 22 0.44 7.77 4.71
159 INT50991 Regulation of Nacc1 3 0.05 7.25 4.7
160 INT37652 Positive_regulation of Pgr 29 0.59 9.09 4.67
161 INT89791 Transcription of Mmp3 7 0.33 2.28 4.64
162 INT97847 Regulation of Ptafr 3 0.43 5.41 4.64
163 INT37335 Gene_expression of Nsdhl 45 0.51 24.36 4.58
164 INT101594 Positive_regulation of Cd40 36 0.69 16.14 4.56
165 INT135990 Positive_regulation of Gene_expression of Cd86 34 0.69 12.02 4.53
166 INT78116 Positive_regulation of Gene_expression of App 12 0.70 10.78 4.52
167 INT62500 Transcription of Ptgs1 10 0.56 4.54 4.52
168 INT92682 Positive_regulation of Gene_expression of Ctgf 17 0.69 12.16 4.51
169 INT24412 Localization of WDTC1 18 0.68 12.45 4.5
170 INT10896 Regulation of PTAFR 16 0.61 4.22 4.5
171 INT26787 Localization of Uchl1 10 0.60 5.9 4.48
172 INT4283 Positive_regulation of Cbs 10 0.46 6.85 4.44
173 INT78524 Positive_regulation of Neu1 6 0.67 8.9 4.4
174 INT88947 Positive_regulation of Gene_expression of Pgr 22 0.64 7 4.39
175 INT69570 Binding of Prnp 75 0.48 44.26 4.37
176 INT148901 Binding of Sort1 2 0.39 3.65 4.32
177 INT57645 Gene_expression of GSTK1 54 0.62 21.05 4.2
178 INT58003 Localization of APP 32 0.80 13.75 4.2
179 INT137239 Gene_expression of CASZ1 8 0.71 4.63 4.19
180 INT1701 Localization of Neu1 11 0.69 6.36 4.18
181 INT287726 Gene_expression of Lpar3 10 0.76 3.89 4.13
182 INT172197 Positive_regulation of Gene_expression of Comt 12 0.69 7.61 4.06
183 INT144302 Protein_catabolism of MMP3 7 0.86 7.43 3.98
184 INT220047 Negative_regulation of Gene_expression of Mmp3 4 0.29 5.93 3.95
185 INT99821 Negative_regulation of Gene_expression of APP 20 0.42 15.21 3.94
186 INT54577 Gene_expression of ZC3H12D 4 0.58 1.72 3.9
187 INT61680 Positive_regulation of PVR 23 0.60 23.27 3.86
188 INT54701 Localization of Ptafr 19 0.49 18.68 3.82
189 INT16787 Negative_regulation of ZC3H12D 8 0.42 2.22 3.82
190 INT140186 Positive_regulation of Gene_expression of Mmp3 7 0.55 6.04 3.82
191 INT52755 Positive_regulation of Sptan1 6 0.67 1.57 3.82
192 INT280193 Positive_regulation of Gene_expression of Cbs 1 0.69 6.59 3.81
193 INT146946 Gene_expression of Lyn 16 0.76 8.9 3.75
194 INT123883 Positive_regulation of Gene_expression of Mmp3 16 0.60 4.42 3.74
195 INT73981 Gene_expression of Hspd1 18 0.75 5.69 3.72
196 INT50022 Positive_regulation of G2e3 10 0.42 0.47 3.72
197 INT136106 Gene_expression of DNMT3B 30 0.58 8.43 3.7
198 INT13302 Binding of PTAFR 20 0.48 7.03 3.7
199 INT308474 Positive_regulation of Transcription of Ptafr 1 0.58 7.33 3.66
200 INT173849 Positive_regulation of Localization of MMP3 7 0.49 4.6 3.65
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