GO:0043234

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Name protein complex
Categary Component
Go Slim Yes
Go Link GO:0043234
Unique Molecular Interactions 4562
Total Molecular Interactions 6142
Total Single Events 51680
Pain Genes Associated 387

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein complex. They are ordered first by their pain relevance and then by number of times they were reported for protein complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6
2 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
3 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
4 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
5 INT296484 Binding of Gria2 and GRIP1 1 0.04 4.52 4.59
6 INT259209 Binding of Glul and Flna 1 0.03 0 4.2
7 INT200322 Binding of Rest and Sp3 1 0.39 2.93 3.98
8 INT130625 Prkcg Regulation of Prkaca 1 0.23 1.32 3.87
9 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71
10 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
11 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
12 INT298456 Prkaca Positive_regulation of Phosphorylation of Adarb1 1 0.00 1.86 2.85
13 INT226118 Ghrl Regulation of Prkag1 1 0.08 0.72 2.72
14 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
15 INT87267 Binding of BMP8B and KRIT1 1 0.06 0.16 2.69
16 INT351444 Grin1 Positive_regulation of Gria2 1 0.22 1.5 2.64
17 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
18 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
19 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
20 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
21 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 0.07 1.72 2.46
22 INT156799 Gria1 Regulation of Grm8 1 0.11 1.29 2.45
23 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
24 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
25 INT131257 ITIH4 Positive_regulation of Gene_expression of Nfkbia 1 0.23 1.41 2.3
26 INT321474 Binding of Slc6a2 and Ubqln1 1 0.00 0.8 2.27
27 INT321477 Binding of Ubqln1 and Flvcr2 1 0.00 0.81 2.26
28 INT135035 Binding of Hk1 and Tac1 1 0.35 0.18 2.14
29 INT66157 Binding of ALB and BDP1 1 0.11 0 2.13
30 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
31 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
32 INT190524 Ros1 Positive_regulation of Nfkb1 3 0.02 4.24 2.06
33 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
34 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
35 INT88883 IRF6 Positive_regulation of Nfkb1 1 0.11 0.53 2.01
36 INT104855 Prkaca Regulation of TRPV1 3 0.06 1.52 1.92
37 INT112514 Binding of Prkaca and Trib3 1 0.03 1.18 1.9
38 INT186432 Prkaca Regulation of Creb1 1 0.14 0.45 1.9
39 INT243043 Binding of Mmp9 and Timp1 1 0.05 0.25 1.86
40 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85
41 INT112517 Binding of Ephb1 and Prkaca 3 0.18 0.58 1.85
42 INT81914 Binding of HSF1 and NFKB1 1 0.05 1.54 1.85
43 INT155460 Tnfrsf1a Positive_regulation of Positive_regulation of Nfkb1 1 0.42 2.39 1.82
44 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
45 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75
46 INT332773 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.04 0.73 1.75
47 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
48 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
49 INT139156 Binding of Gria1 and Gria2 1 0.23 0.64 1.72
50 INT139190 Binding of Fadd and Fas 4 0.38 2.65 1.71
51 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
52 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
53 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
54 INT105917 Binding of SLC22A6 and SLC22A8 2 0.31 0.34 1.67
55 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 0.01 0.95 1.67
56 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
57 INT122428 Binding of Ighm and Prkci 1 0.00 0 1.66
58 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
59 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65
60 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
61 INT297489 Ryr2 Regulation of Positive_regulation of Ltp 1 0.05 0.16 1.64
62 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 0.12 0.54 1.63
63 INT155459 Tnfrsf1a Positive_regulation of Nfkb1 1 0.42 2.45 1.63
64 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
65 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
66 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
67 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
68 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58
69 INT168611 Binding of Mmp9 and Ndor1 1 0.29 0.41 1.57
70 INT212660 Nr3c1 Regulation of KCNA1 1 0.00 1.25 1.57
71 INT168608 Binding of Grin2b and Mmp9 1 0.22 0.41 1.57
72 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
73 INT130838 Gfap Positive_regulation of Aqp4 1 0.51 1.9 1.56
74 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
75 INT284785 Gch1 Regulation of Bh4p 1 0.00 1.48 1.54
76 INT256360 Car2 Positive_regulation of Localization of Rela 1 0.14 0 1.51
77 INT229094 Binding of IL1RN and Il1r1 1 0.01 1.9 1.5
78 INT121741 Prkaca Negative_regulation of Positive_regulation of Creb1 1 0.10 0.2 1.49
79 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48
80 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47
81 INT104975 MITF Regulation of Transcription of PRSS1 1 0.68 0.35 1.46
82 INT104972 MITF Regulation of Transcription of TYR 1 0.20 0.35 1.45
83 INT190773 Il4 Negative_regulation of Gene_expression of Ptgs2 1 0.06 1.26 1.45
84 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
85 INT190774 Il4 Negative_regulation of Positive_regulation of Ptgs2 1 0.06 1.26 1.45
86 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
87 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
88 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
89 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
90 INT78974 Binding of Prkcg and Prkaca 2 0.31 0.35 1.4
91 INT262568 Prkaca Regulation of Trpv1 2 0.10 0.65 1.38
92 INT167169 Nfkb1 Regulation of Gene_expression of Crp 1 0.09 1.76 1.38
93 INT87266 Negative_regulation of Binding of BMP8B and KRIT1 1 0.05 0.07 1.37
94 INT122430 Negative_regulation of Binding of Ighm and Prkci 1 0.00 0 1.36
95 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
96 INT158079 Binding of Esr1 and Gper 1 0.31 0.97 1.35
97 INT222182 Binding of ESR1 and HLA-DRB2 1 0.00 3.1 1.35
98 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
99 INT178986 Binding of MMP9 and TIMP1 4 0.47 2.58 1.33
100 INT39950 Binding of ALB and PDYN 1 0.31 0 1.32
101 INT150890 Binding of Esr1 and Esr2 2 0.52 2.06 1.31
102 INT131256 Positive_regulation of Nfkb1 Positive_regulation of Gene_expression of Nfkbia 1 0.38 0.94 1.31
103 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
104 INT124926 Negative_regulation of Prkaca Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3
105 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
106 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
107 INT114929 Positive_regulation of Binding of Oprm1 and Crebbp 1 0.06 0.14 1.28
108 INT161995 Binding of Ctu2 and Fbxo23 1 0.06 0.33 1.28
109 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
110 INT154203 Binding of Pick1 and Grm7 1 0.41 1.64 1.28
111 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
112 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
113 INT100816 PPP1R14C Regulation of Ppp1cc 1 0.08 0 1.27
114 INT114925 Binding of Oprm1 and Crebbp 1 0.06 0.14 1.27
115 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
116 INT121464 Negative_regulation of Oprm1 Positive_regulation of Dnm2 1 0.34 0 1.26
117 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25
118 INT116628 St13 Regulation of Positive_regulation of P9Ehs1 1 0.00 0 1.25
119 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
120 INT202042 CAMK2N2 Negative_regulation of MMP9 1 0.01 0.73 1.25
121 INT121465 Binding of Dnm2 and Oprm1 1 0.23 0 1.24
122 INT202036 CAMK2N2 Negative_regulation of MMP3 1 0.00 0.73 1.24
123 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
124 INT141244 Fos Regulation of Prkaca 1 0.18 0.07 1.24
125 INT195926 Prkaca Positive_regulation of Trpv1 1 0.10 0.44 1.24
126 INT341218 Binding of Eif4e and Eif4ebp1 1 0.19 2.65 1.23
127 INT75229 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.44 0 1.22
128 INT76163 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.02 0.08 1.22
129 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
130 INT285185 Binding of Ca2 and Cd2 1 0.25 0.24 1.21
131 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
132 INT187172 RPS3AP9 Negative_regulation of MMP9 1 0.00 0.89 1.2
133 INT228681 Fkbp4 Negative_regulation of Trib3 1 0.00 0.57 1.2
134 INT281077 Binding of Gria2 and Gria3 2 0.24 0.35 1.19
135 INT162419 Binding of Abpa and Cftr 1 0.04 1.66 1.19
136 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
137 INT321475 Slc6a2 Positive_regulation of Ubqln1 1 0.00 0.38 1.19
138 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
139 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17
140 INT85780 Prkaca Regulation of Prkcg 1 0.29 0.47 1.17
141 INT131887 Nr3c1 Regulation of Gene_expression of Prkcg 1 0.01 0 1.17
142 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
143 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
144 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16
145 INT200312 Rest Regulation of Oprm1 1 0.23 0.27 1.16
146 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
147 INT19535 Binding of ADRA1D and ALB 3 0.42 0.8 1.15
148 INT160653 Binding of P2rx1 and Ptgfr 1 0.28 0.66 1.14
149 INT123387 Binding of Camk2a and Gria2 1 0.13 0.32 1.14
150 INT321473 Binding of Slc6a3 and Ubqln1 1 0.00 0.41 1.13
151 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
152 INT196812 Ppp1r1b Negative_regulation of Ppp1cc 3 0.07 0.13 1.12
153 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
154 INT109374 Ppp1cc Negative_regulation of Ppp2r1a 1 0.24 0 1.11
155 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
156 INT269200 Prkaca Positive_regulation of Phosphorylation of Ceacam3 1 0.03 0.65 1.09
157 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
158 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
159 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
160 INT352468 Calca Positive_regulation of Prkaca 1 0.11 0.8 1.08
161 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
162 INT96906 Plxna3 Regulation of Regulation of Prkaca 1 0.17 0.71 1.08
163 INT296458 Binding of Gria2 and Pick1 3 0.24 1.86 1.07
164 INT161011 Binding of Cpe and St13 2 0.03 0.61 1.07
165 INT83936 Binding of Mtap2 and Penk 1 0.22 0.19 1.07
166 INT296460 Binding of Gria2 and Myo18a 1 0.01 1.49 1.06
167 INT269198 Prkaca Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
168 INT122432 Prkci Regulation of Negative_regulation of Oprd1 1 0.01 0 1.06
169 INT266742 GOPC Regulation of Positive_regulation of ACR 1 0.02 0.36 1.05
170 INT269199 Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.03 0.56 1.05
171 INT126401 ITIH4 Positive_regulation of Gene_expression of Ptgs2 1 0.00 1.05 1.04
172 INT69011 Binding of Cebpb and Nfkb1 1 0.19 0.75 1.04
173 INT139752 Ubqln1 Regulation of Localization of Prl 1 0.05 0 1.04
174 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
175 INT200307 Rest Negative_regulation of Rorb 1 0.00 0.1 1.03
176 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
177 INT88881 Negative_regulation of IRF6 Positive_regulation of Nfkb1 1 0.09 0.27 1.03
178 INT95378 Binding of Jun and Jund 5 0.20 2.06 1.02
179 INT98555 Oprm1 Positive_regulation of Casp8 1 0.51 0.36 1.02
180 INT122429 Prkci Regulation of Gene_expression of Ighm 1 0.00 0 1.02
181 INT122431 Prkci Negative_regulation of Negative_regulation of Ighm 1 0.00 0 1.02
182 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02
183 INT74934 Regulation of IRF6 Positive_regulation of Nfkb1 1 0.01 0.52 1.02
184 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
185 INT122433 Prkci Negative_regulation of Ighm 1 0.00 0 1.02
186 INT240453 Prkcg Positive_regulation of Positive_regulation of Prkaca 1 0.23 0.63 1.01
187 INT144661 Dnm1 Negative_regulation of Binding of Hbegf 1 0.24 0 1.01
188 INT240455 Ephb1 Positive_regulation of Positive_regulation of Prkaca 1 0.22 0.63 1.01
189 INT74933 IRF6 Positive_regulation of Nfkb1 1 0.02 0.52 1.01
190 INT143177 Apcs Negative_regulation of Gene_expression of Fos 1 0.02 0.36 1.01
191 INT88879 Ifng Positive_regulation of Nfkb1 1 0.01 0.26 1.01
192 INT186161 Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.11 1.05 1.01
193 INT320021 Prkaca Regulation of Positive_regulation of Kcnma1 1 0.00 0.54 1
194 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 0.13 0.07 1
195 INT317568 Prkca Regulation of Negative_regulation of Oprm1 1 0.10 0.07 1
196 INT73681 Regulation of KNG1 Positive_regulation of ALB 1 0.30 0.38 0.99
197 INT156510 Nfkb1 Regulation of Positive_regulation of Grin1 1 0.03 0.98 0.98
198 INT130232 Binding of Cat and Sod1 1 0.35 0.3 0.98
199 INT73680 KNG1 Positive_regulation of ALB 1 0.51 0.38 0.98
200 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein complex. They are ordered first by their pain relevance and then by number of times they were reported in protein complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85
2 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
3 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
4 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73
5 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51
6 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06
7 INT52651 Positive_regulation of Prkaca 136 0.67 40.82 99.16
8 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
9 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
10 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54
11 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
12 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37
13 INT49111 Negative_regulation of Prkaca 102 0.59 27.44 71.77
14 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52
15 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34
16 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08
17 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
18 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
19 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6
20 INT546 Binding of ALB 311 0.48 85.98 60.14
21 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81
22 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01
23 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
24 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73
25 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5
26 INT8071 Positive_regulation of Gria1 102 0.70 26.61 53.37
27 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71
28 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05
29 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39
30 INT117598 Regulation of ACR 118 0.26 41.25 48.01
31 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
32 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81
33 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38
34 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02
35 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9
36 INT613 Gene_expression of Alb 268 0.78 149.84 42.78
37 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78
38 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
39 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
40 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
41 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
42 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75
43 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55
44 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48
45 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46
46 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
47 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
48 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45
49 INT64436 Gene_expression of P2rx1 93 0.78 32.69 36.12
50 INT65055 Negative_regulation of Nfkb1 83 0.58 44.85 34.94
51 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
52 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
53 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
54 INT65536 Negative_regulation of Positive_regulation of Nfkb1 77 0.59 38.86 33.33
55 INT234 Binding of Alb 151 0.48 52.34 32.97
56 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
57 INT99610 Localization of MMP9 126 0.79 48.46 32.67
58 INT81530 Gene_expression of Nfkb1 93 0.78 48.58 32.58
59 INT89055 Phosphorylation of Prkaca 60 0.61 13.41 32.49
60 INT114173 Phosphorylation of Gria1 27 0.82 33.73 31.24
61 INT49001 Regulation of Gria1 51 0.56 18.28 31.22
62 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
63 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
64 INT70776 Positive_regulation of P2rx1 62 0.62 32.55 30.75
65 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
66 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04
67 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02
68 INT64918 Gene_expression of Gria2 108 0.74 29.95 29.67
69 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65
70 INT130837 Gene_expression of Aqp4 205 0.78 151.23 29.63
71 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
72 INT56525 Gene_expression of Gria2 74 0.75 23.15 28.6
73 INT87212 Negative_regulation of Positive_regulation of Nfkb1 74 0.57 38.21 28.31
74 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96
75 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
76 INT37296 Binding of Esr1 117 0.43 62.51 27.33
77 INT5923 Negative_regulation of Rtn4 50 0.36 24.19 27.2
78 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7
79 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42
80 INT65537 Positive_regulation of Positive_regulation of Nfkb1 52 0.67 30.6 26.35
81 INT20462 Binding of ESR1 210 0.44 102.7 26.34
82 INT86062 Positive_regulation of Tnfrsf1a 51 0.69 40.69 26.2
83 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85
84 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
85 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
86 INT140193 Gene_expression of Mmp3 58 0.71 49.65 25.4
87 INT93717 Gene_expression of Mmp3 85 0.78 33.95 24.89
88 INT96904 Regulation of Prkaca 33 0.44 10.86 24.51
89 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03
90 INT9155 Gene_expression of Glul 60 0.77 17.97 23.95
91 INT101225 Positive_regulation of Gria2 62 0.64 28.1 23.93
92 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
93 INT66758 Binding of Nfkb1 97 0.48 50.65 23.65
94 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09
95 INT71875 Localization of Nfkb1 92 0.78 48.13 22.94
96 INT76249 Gene_expression of Gria1 67 0.75 15.07 22.78
97 INT12114 Positive_regulation of Tnfrsf1a 46 0.69 36.26 22.54
98 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52
99 INT7678 Localization of Alb 142 0.81 80.93 22.49
100 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
101 INT2911 Positive_regulation of Glul 36 0.70 11.09 22.07
102 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22
103 INT103842 Gene_expression of Cftr 53 0.78 59.59 21.82
104 INT49623 Negative_regulation of Gria1 39 0.59 12.4 21.59
105 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18
106 INT117527 Binding of Prkca 25 0.48 6.43 21.05
107 INT129987 Phosphorylation of Gria1 63 0.80 20.65 21.02
108 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95
109 INT52529 Regulation of Nfkb1 48 0.61 26.2 20.89
110 INT89805 Gene_expression of Prkaca 45 0.77 11.03 20.77
111 INT109650 Gene_expression of Aqp4 87 0.78 51.52 20.72
112 INT69877 Positive_regulation of Positive_regulation of Nfkb1 53 0.68 31.44 20.7
113 INT17848 Binding of PTGS2 70 0.46 32.1 20.6
114 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
115 INT101188 Gene_expression of Rela 81 0.56 23.43 19.15
116 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
117 INT56239 Positive_regulation of Rtn4 20 0.26 14.05 18.8
118 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35
119 INT30197 Positive_regulation of Ubqln1 26 0.08 2.07 18.28
120 INT112017 Regulation of Hand2 77 0.36 62.23 18.04
121 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
122 INT5922 Gene_expression of Rtn4 27 0.48 12.7 17.86
123 INT29709 Positive_regulation of Gene_expression of Gria1 36 0.69 9.43 17.83
124 INT132997 Localization of Mmp9 59 0.80 45.9 17.61
125 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53
126 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52
127 INT17237 Regulation of Esr1 74 0.43 49.09 17.25
128 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1
129 INT95930 Negative_regulation of Gria2 63 0.56 18.37 17.04
130 INT62564 Gene_expression of Syp 40 0.76 15.56 17
131 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
132 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
133 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
134 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17
135 INT62861 Regulation of Gria2 45 0.60 13.35 16.07
136 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
137 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95
138 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
139 INT79458 Localization of Prkca 30 0.81 11.13 15.78
140 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7
141 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
142 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
143 INT92354 Localization of ESR1 77 0.75 33.04 15.51
144 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
145 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
146 INT615 Regulation of Alb 66 0.62 33.43 15.33
147 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31
148 INT1850 Binding of OXA1L 77 0.48 7.61 15.22
149 INT81486 Localization of MMP3 31 0.81 12.94 15.21
150 INT143276 Phosphorylation of Gria2 42 0.80 16.07 15.2
151 INT24798 Negative_regulation of Glul 52 0.55 27.25 15.17
152 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15
153 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07
154 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06
155 INT114172 Positive_regulation of Phosphorylation of Gria1 8 0.63 15.73 14.99
156 INT114510 Positive_regulation of Gria2 36 0.57 14.91 14.85
157 INT93482 Localization of Rela 56 0.78 24.52 14.82
158 INT52696 Positive_regulation of Ptgs2 48 0.70 27.65 14.44
159 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36
160 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
161 INT61864 Regulation of Gene_expression of Gria1 24 0.62 13.27 14.3
162 INT77619 Gene_expression of Prkaca 43 0.75 8.55 14.13
163 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
164 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
165 INT11069 Positive_regulation of Pf4 35 0.68 27.7 13.96
166 INT18773 Localization of ALB 117 0.80 69.18 13.8
167 INT53070 Regulation of Rtn4 15 0.22 9.35 13.77
168 INT111529 Phosphorylation of Mapk3 41 0.80 21.14 13.72
169 INT90942 Regulation of P2rx1 31 0.61 16.61 13.69
170 INT173505 Localization of Hand2 63 0.57 45.32 13.66
171 INT78480 Localization of Nfkb1 39 0.80 23.14 13.64
172 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
173 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
174 INT71879 Negative_regulation of Localization of Nfkb1 30 0.57 21.8 13.48
175 INT95427 Positive_regulation of Mmp3 39 0.70 15.28 13.36
176 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36
177 INT49538 Binding of Gria1 22 0.47 2.66 13.35
178 INT2038 Localization of Esr1 104 0.79 40.12 13.27
179 INT59665 Positive_regulation of Ugt1a6 24 0.69 7.24 13.25
180 INT144646 Positive_regulation of Rela 53 0.67 27.78 13.2
181 INT174838 Localization of INCENP 80 0.64 19.05 12.89
182 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82
183 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82
184 INT84307 Binding of Cftr 31 0.47 26.19 12.8
185 INT195226 Positive_regulation of ACR 23 0.26 7.85 12.62
186 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52
187 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4
188 INT59080 Negative_regulation of Gene_expression of PTGS2 55 0.58 22.92 12.39
189 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
190 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
191 INT104569 Gene_expression of Aqp2 23 0.60 16.56 12.23
192 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18
193 INT111948 Positive_regulation of Gria1 23 0.61 7.55 12.03
194 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
195 INT86698 Gene_expression of Cav1 38 0.78 16.37 11.75
196 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73
197 INT127981 Gene_expression of Trpc1 25 0.77 10.51 11.67
198 INT65057 Regulation of Nfkb1 28 0.47 16.48 11.62
199 INT78970 Positive_regulation of Positive_regulation of Prkaca 14 0.47 3.06 11.49
200 INT105754 Regulation of St13 8 0.28 0.75 11.41
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