GO:0043235

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Name receptor complex
Categary Component
Go Slim No
Go Link GO:0043235
Unique Molecular Interactions 406
Total Molecular Interactions 669
Total Single Events 5466
Pain Genes Associated 48

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for receptor complex. They are ordered first by their pain relevance and then by number of times they were reported for receptor complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT166590 Binding of RAMP1 and DCLK3 2 0.37 0.39 4.8
2 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
3 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
4 INT166592 Binding of CALCA and RAMP1 2 0.35 0.33 2.91
5 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
6 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
7 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
8 INT148935 Ramp1 Regulation of Calca 1 0.27 0.69 1.56
9 INT69562 Positive_regulation of AP2M1 Positive_regulation of Regulation of Adrb3 1 0.01 0.19 1.24
10 INT197231 Grik1 Regulation of Gabrg1 1 0.19 0.13 1.22
11 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
12 INT222516 Binding of Calcrl and Ramp1 5 0.17 0.11 1.12
13 INT107938 POMC Positive_regulation of Gene_expression of TGFBR2 1 0.42 1.09 1.07
14 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
15 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
16 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
17 INT127263 Adra2a Regulation of Gene_expression of Jun 1 0.07 1.1 0.95
18 INT45279 Binding of CSF2 and GHR 1 0.05 0.07 0.93
19 INT28921 Adra2a Positive_regulation of Localization of Prl 1 0.24 0 0.9
20 INT43796 Binding of CDS1 and Adra2a 1 0.06 0 0.86
21 INT42865 Binding of Adrb2 and Man2a2 1 0.23 1.03 0.85
22 INT42864 Regulation of Binding of Adrb2 and Man2a2 1 0.28 1.03 0.85
23 INT107937 POMC Regulation of Gene_expression of TGFBR2 1 0.28 0.82 0.81
24 INT73775 Binding of GH1 and GHR 4 0.35 0.68 0.8
25 INT63544 Adra2a Regulation of Nisch 1 0.18 0 0.79
26 INT141963 Binding of CALCRL and RAMP1 2 0.43 0.81 0.78
27 INT346133 RAMP2 Regulation of ADM 1 0.13 2.06 0.78
28 INT161951 Positive_regulation of TGFBR1 Positive_regulation of Gene_expression of Ngf 1 0.27 0.99 0.76
29 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
30 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
31 INT73776 Regulation of Binding of GH1 and GHR 2 0.26 0.16 0.75
32 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
33 INT84283 Binding of Adra2a and Htr1f 1 0.16 0.15 0.74
34 INT284306 Tlr4 Positive_regulation of Adrb3 1 0.00 1.19 0.74
35 INT284307 Mir155 Regulation of Adrb3 1 0.00 3.44 0.73
36 INT142507 Binding of Calca and Ramp1 1 0.31 0.48 0.73
37 INT161950 TGFBR1 Negative_regulation of Localization of Ngf 1 0.23 1.01 0.72
38 INT197234 Grik1 Positive_regulation of Localization of Gabrg1 1 0.15 0.82 0.71
39 INT20688 Adra2a Regulation of Localization of Gh1 1 0.26 0.37 0.7
40 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
41 INT231533 IL4 Positive_regulation of LRP5 1 0.00 0.87 0.67
42 INT132152 Adra2a Regulation of Localization of Abat 1 0.03 0 0.66
43 INT153921 Positive_regulation of Adra2a Regulation of Ednrb 1 0.01 0 0.66
44 INT197238 Grik1 Regulation of Gene_expression of Gabrg1 1 0.17 0.13 0.64
45 INT17187 Binding of Adra2a and Fabp6 1 0.16 0.69 0.61
46 INT197239 Grik1 Regulation of Localization of Gabrg1 1 0.10 0.56 0.61
47 INT17186 Positive_regulation of Binding of Adra2a and Fabp6 1 0.21 0.69 0.61
48 INT201294 Negative_regulation of Grik1 Negative_regulation of Gabrg1 1 0.30 0 0.6
49 INT57246 Crh Positive_regulation of Positive_regulation of Caprin2 1 0.01 0.55 0.6
50 INT202160 Binding of ARSD and CSF1R 1 0.16 1.69 0.59
51 INT41250 Binding of Adra2a and Eef1a1 1 0.06 0.4 0.56
52 INT195773 Binding of Cd74 and Mif 2 0.25 2.78 0.55
53 INT176343 CHI3L1 Positive_regulation of Localization of CSF1 1 0.23 1.86 0.55
54 INT202157 Binding of CSF1R and SLC6A4 1 0.08 0.9 0.54
55 INT176342 CSF1 Positive_regulation of Localization of CSF2 1 0.26 1.84 0.54
56 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
57 INT155406 Binding of Adrb2 and Ngf 1 0.05 0.39 0.53
58 INT3218 Adrb2 Positive_regulation of Localization of Ins1 1 0.10 0 0.52
59 INT302644 ARSA Positive_regulation of Gene_expression of TGFBR1 1 0.04 0.29 0.51
60 INT346205 Binding of CD74 and TPPP 1 0.02 0.87 0.51
61 INT66188 Binding of ADRB2 and CDSN 1 0.01 0 0.51
62 INT302647 ARSA Positive_regulation of TGFBR1 1 0.03 0.29 0.51
63 INT7851 Man2a2 Positive_regulation of Adra2a 1 0.13 0 0.49
64 INT146113 Binding of Adra2a and Lrp1 1 0.01 1.07 0.48
65 INT141964 Binding of ADM and RAMP1 1 0.30 2.63 0.47
66 INT138424 Binding of RAMP1 and Calca 1 0.01 0.08 0.47
67 INT26448 Adra2a Regulation of Positive_regulation of Npy 1 0.06 0 0.46
68 INT195774 Binding of MIF and Cd74 1 0.02 1.15 0.46
69 INT35167 Adrb2 Positive_regulation of Trh 1 0.05 0 0.45
70 INT86380 Adra2a Regulation of Gene_expression of Tnf 1 0.15 0.79 0.44
71 INT194405 DCLK3 Positive_regulation of Gene_expression of RAMP1 1 0.16 0.09 0.43
72 INT56576 Adra2a Positive_regulation of Localization of Gnrh1 1 0.44 0 0.43
73 INT55395 Binding of Htr1a and Adra2a 1 0.42 0 0.43
74 INT92744 Binding of ADRB2 and NF2 1 0.00 0.1 0.41
75 INT75488 Binding of TGFB1 and Tgfbr1 1 0.23 0.78 0.41
76 INT75489 Binding of SGCG and Tgfbr2 1 0.23 0.83 0.41
77 INT75487 Binding of TGFB1 and Tgfbr2 1 0.31 0.83 0.41
78 INT34987 Adra2a Positive_regulation of Localization of Gnrhr 1 0.43 0 0.4
79 INT223474 Binding of Grik1 and P2rx3 1 0.03 0.36 0.4
80 INT70663 Adrb3 Regulation of Cck 1 0.14 0 0.4
81 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39
82 INT163831 ERBB2 Positive_regulation of CCND1 1 0.03 0.82 0.38
83 INT70656 Adra2a Regulation of Gene_expression of Npy 1 0.23 0 0.38
84 INT298588 IL1B Regulation of Gene_expression of CSF1 1 0.35 0.59 0.36
85 INT174459 IL8 Positive_regulation of Gene_expression of Cd74 1 0.00 0.61 0.35
86 INT67030 Negative_regulation of Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
87 INT67028 Adra2a Negative_regulation of Nts 1 0.06 0.64 0.33
88 INT67029 Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
89 INT263974 Binding of ADRB2 and NR4A3 1 0.01 0.5 0.32
90 INT31182 Adra2a Regulation of Localization of Gh 1 0.01 0.35 0.32
91 INT263978 Binding of ADRB2 and TNFAIP3 1 0.01 0.5 0.32
92 INT138423 Binding of RAMP3 and Calca 1 0.01 0 0.32
93 INT153924 Msr1 Regulation of Adrb3 1 0.02 0.24 0.32
94 INT263979 Binding of ADRB2 and ATF3 1 0.01 0.5 0.32
95 INT342457 CSF1 Negative_regulation of Gene_expression of CCR4 1 0.00 0.93 0.31
96 INT326090 Binding of Erbb2 and Mmp2 1 0.09 1.39 0.31
97 INT119333 Binding of Ramp2 and Positive_regulation of Gpr182 1 0.18 0.13 0.3
98 INT119332 Binding of Ramp3 and Positive_regulation of Gpr182 1 0.18 0.13 0.3
99 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29
100 INT194406 Binding of RAMP1 and RPL34P34 1 0.00 0 0.29
101 INT355038 NRP1 Negative_regulation of CKAP4 1 0.02 1.23 0.29
102 INT144434 Gene_expression of Erbb2 Positive_regulation of ras 1 0.16 0.6 0.28
103 INT177978 Binding of CSF1R and SNRNP70 1 0.02 1.49 0.28
104 INT342458 CSF1 Positive_regulation of Gene_expression of CCL2 1 0.17 0.84 0.27
105 INT177977 RUNX1 Regulation of CSF1R 1 0.14 1 0.27
106 INT95061 Binding of Adra2a and ADHD1 1 0.02 0.8 0.27
107 INT311918 Insrr Negative_regulation of Tgfbr1 1 0.00 0.87 0.26
108 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26
109 INT42635 Adra2a Positive_regulation of epi 1 0.00 0 0.26
110 INT197235 Binding of Grik1 and Kars 1 0.32 0.1 0.25
111 INT84607 Oprl1 Regulation of Adrb3 1 0.19 0.25 0.24
112 INT284297 Mir155 Positive_regulation of Adrb3 1 0.01 0.51 0.24
113 INT290376 Binding of CSF1R and MEFV 1 0.29 0.31 0.24
114 INT55641 Binding of CHRM1 and Adra2a 1 0.00 0 0.24
115 INT284299 Adrb3 Positive_regulation of Gene_expression of Mir155 1 0.01 0.51 0.24
116 INT89469 Fk Positive_regulation of Gene_expression of Lhcgr 1 0.01 0 0.24
117 INT311911 Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
118 INT34499 ADRB3 Positive_regulation of ADCY1 1 0.07 0.19 0.23
119 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
120 INT89470 CGA Regulation of Gene_expression of Lhcgr 1 0.00 0 0.23
121 INT89468 Fk Regulation of Gene_expression of Lhcgr 1 0.01 0 0.23
122 INT29099 Binding of ADRB2 and PPAP2A 1 0.03 0.77 0.22
123 INT32735 ADRA2A Regulation of RTCA 1 0.07 0 0.22
124 INT291352 Positive_regulation of CXCL12 Positive_regulation of ERBB2 1 0.17 0.88 0.22
125 INT194404 Binding of RAMP2 and DCLK3 1 0.07 0 0.22
126 INT144433 Gene_expression of Erbb2 Positive_regulation of Positive_regulation of Mapk3 1 0.41 0.56 0.21
127 INT335888 Lrp5 Negative_regulation of Gene_expression of Tph1 1 0.22 0.15 0.21
128 INT143618 Msr1 Positive_regulation of Adrb3 1 0.16 0.85 0.2
129 INT142578 Binding of CSF1 and Crp 1 0.01 1.2 0.2
130 INT203850 Binding of Tradd and Lna1 1 0.10 0.4 0.2
131 INT351086 Negative_regulation of ERBB2 Positive_regulation of Gene_expression of ESR1 1 0.10 0.75 0.19
132 INT355365 CSF1 Positive_regulation of Tnfsf11 1 0.03 1.49 0.19
133 INT251665 LRP5 Negative_regulation of Ache 1 0.31 0.39 0.19
134 INT355366 Regulation of CSF1 Positive_regulation of Tnfsf11 1 0.02 1.5 0.19
135 INT172246 TAS2R14 Positive_regulation of Gene_expression of RAMP1 1 0.01 0.07 0.18
136 INT351088 Negative_regulation of ERBB2 Positive_regulation of FOXO3 1 0.17 0.66 0.18
137 INT40819 Binding of ADRB3 and AGPAT1 1 0.24 0 0.18
138 INT222300 Binding of ERBB2 and PGR 2 0.34 1.89 0.17
139 INT172251 CALCRL Positive_regulation of Gene_expression of RAMP1 1 0.04 0.07 0.17
140 INT349659 PYCARD Positive_regulation of ADRB2 1 0.06 0.19 0.17
141 INT172232 CALCRL Positive_regulation of Gene_expression of NRP1 1 0.02 0.07 0.17
142 INT115610 Binding of ERBB2 and KLF1 1 0.02 2.12 0.17
143 INT172237 TAS2R14 Positive_regulation of Gene_expression of NRP1 1 0.01 0.07 0.17
144 INT293712 Binding of Adra2a and Atl1 1 0.06 0.83 0.15
145 INT128705 Binding of Adrb2 and Ahsg 1 0.00 0.23 0.15
146 INT174892 Binding of ADRB3 and ENPP3 1 0.04 0.4 0.14
147 INT95103 TGFBR2 Positive_regulation of CD34 1 0.11 0.61 0.14
148 INT95104 TGFBR2 Positive_regulation of BCL2 1 0.08 0.61 0.14
149 INT103425 Binding of Adra2a and Cyth2 1 0.00 0 0.14
150 INT109082 Adra2a Regulation of Nppa 1 0.21 0.56 0.14
151 INT43495 Cd74 Regulation of Gene_expression of Ifng 1 0.47 0 0.14
152 INT175398 Binding of ERBB2 and VEGFA 2 0.16 1.34 0.13
153 INT298052 Binding of Cd74 and Vip 1 0.00 1.05 0.13
154 INT87839 Binding of Cd74 and Dcn 1 0.36 0.21 0.13
155 INT235775 Binding of Tnfrsf1a and Tradd 3 0.31 3 0.12
156 INT200326 Hdac1 Negative_regulation of Lhcgr 1 0.03 0 0.12
157 INT284298 Adrb3 Regulation of Mir155 1 0.00 0.24 0.12
158 INT252632 Binding of Casp3 and Tradd 1 0.11 0.68 0.12
159 INT200318 Hdac1 Negative_regulation of Transcription of Lhcgr 1 0.03 0 0.12
160 INT200346 Hdac2 Negative_regulation of Lhcgr 1 0.04 0 0.12
161 INT279799 ATP6V0A2 Regulation of ERBB3 1 0.00 1.77 0.12
162 INT200347 Hdac2 Negative_regulation of Transcription of Lhcgr 1 0.04 0 0.12
163 INT254227 Binding of Ripk1 and Ticam1 3 0.07 0.18 0.11
164 INT177980 CSF1R Regulation of PXN 1 0.07 0.48 0.11
165 INT50533 Binding of ADRB3 and Positive_regulation of Gene_expression of CA3 1 0.11 0.61 0.1
166 INT17394 Adra2a Positive_regulation of GNAI1 1 0.02 0.37 0.1
167 INT341826 Binding of ERBB2 and TNC 1 0.18 0.63 0.09
168 INT94411 Positive_regulation of ADRB3 Negative_regulation of Gene_expression of TNF 1 0.19 0.15 0.09
169 INT33806 IL2 Regulation of ADRB3 1 0.28 0.08 0.09
170 INT232557 Erbb2 Positive_regulation of Esr1 1 0.23 0.26 0.09
171 INT250661 Binding of EGF and ERBB2 2 0.11 0.82 0.08
172 INT251569 Binding of Ripk1 and Traf2 1 0.12 0.67 0.08
173 INT66171 Negative_regulation of Adra2a Negative_regulation of Positive_regulation of Pnmt 1 0.38 0 0.08
174 INT309904 Binding of ERBB2 and TXK 1 0.01 0.23 0.08
175 INT311917 Gene_expression of Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.31 0.08
176 INT284310 Mir155 Negative_regulation of Adrb3 1 0.00 0.55 0.08
177 INT337084 Negative_regulation of Binding of Cd74 and Mif 1 0.29 1.64 0.08
178 INT251566 Binding of Ripk1 and Gtf3a 1 0.00 0.67 0.08
179 INT339111 Binding of ERBB2 and JUP 1 0.38 0.62 0.07
180 INT66166 Negative_regulation of Binding of Pnmt and Adra2a 1 0.38 0 0.07
181 INT293813 ERBB2 Positive_regulation of Positive_regulation of AR 1 0.09 0.45 0.07
182 INT66167 Negative_regulation of Pnmt Negative_regulation of Adra2a 1 0.38 0 0.07
183 INT66172 Binding of Pnmt and Adra2a 1 0.33 0 0.07
184 INT311915 Tgfbr1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
185 INT127722 CSF1 Positive_regulation of TNFSF11 1 0.08 0.26 0.06
186 INT339101 ERBB2 Positive_regulation of TGFA 1 0.33 0.68 0.06
187 INT222479 Binding of Ramp1 and Rxfp2 1 0.01 0 0.06
188 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06
189 INT339099 ERBB2 Positive_regulation of IGF2R 1 0.33 0.67 0.06
190 INT339105 ERBB2 Positive_regulation of EGFR 1 0.37 0.68 0.06
191 INT127723 CSF1 Positive_regulation of TRAT1 1 0.01 0.26 0.06
192 INT339110 ERBB2 Positive_regulation of GATA6 1 0.31 0.67 0.06
193 INT235547 CSF1 Positive_regulation of Gene_expression of Csf2 1 0.00 0.52 0.05
194 INT222559 Binding of Ramp3 and Ramp1 1 0.02 0 0.05
195 INT222485 Binding of Iapp and Ramp1 1 0.09 0 0.05
196 INT173051 Binding of VEGFA and NRP1 16 0.44 1.29 0.04
197 INT213903 Binding of EGFR and ERBB2 10 0.37 5.03 0.04
198 INT173056 Binding of NRP2 and NRP1 2 0.24 0.61 0.04
199 INT265771 NRP1 Positive_regulation of VEGFA 1 0.46 0 0.04
200 INT213901 EGFR Positive_regulation of ERBB2 1 0.52 0.41 0.04

Single Events

The table below shows the top 100 pain related interactions that have been reported for receptor complex. They are ordered first by their pain relevance and then by number of times they were reported in receptor complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
2 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
3 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
4 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
5 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
6 INT3030 Gene_expression of Adra2a 37 0.68 5.58 19.76
7 INT124670 Gene_expression of Grik1 53 0.77 4.83 19.13
8 INT14114 Binding of Adra2a 30 0.48 4.24 18.53
9 INT12875 Regulation of Adra2a 26 0.45 7.51 17.35
10 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
11 INT197210 Positive_regulation of Grik1 24 0.69 3.15 16.24
12 INT5674 Gene_expression of Adra2a 34 0.77 6.14 15.13
13 INT663 Negative_regulation of Adrb3 55 0.59 15.95 14.68
14 INT110 Regulation of Adrb3 33 0.60 8.09 13.84
15 INT46619 Gene_expression of CSF1 80 0.73 36.63 12.94
16 INT102448 Gene_expression of RAMP1 23 0.75 4.62 10.9
17 INT8188 Positive_regulation of Adrb3 27 0.68 7.32 10.44
18 INT12455 Negative_regulation of Adra2a 30 0.54 5.63 10.14
19 INT17283 Positive_regulation of CSF1 37 0.59 24.16 10.01
20 INT29411 Positive_regulation of ADRB2 13 0.65 5.42 8.78
21 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66
22 INT298 Negative_regulation of ADRB3 23 0.59 6.82 7.56
23 INT7883 Binding of ADRB2 18 0.47 5.49 7.37
24 INT6576 Localization of Adra2a 11 0.71 1.49 7.18
25 INT21138 Binding of ADRA2A 16 0.48 5.57 6.8
26 INT197216 Localization of Grik1 9 0.80 0.39 6.78
27 INT120200 Binding of RAMP1 6 0.47 0.72 6.16
28 INT1243 Regulation of ADRB2 16 0.54 1.84 5.66
29 INT9895 Binding of GHR 18 0.36 4.8 5.65
30 INT152433 Binding of CSF1R 6 0.33 10.97 5.54
31 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23
32 INT13885 Positive_regulation of Adrb2 9 0.49 1.11 5.12
33 INT13650 Positive_regulation of Gene_expression of Adra2a 6 0.50 0.69 4.94
34 INT7716 Positive_regulation of Positive_regulation of Adra2a 9 0.68 0.8 4.69
35 INT109248 Gene_expression of Ramp1 8 0.72 2.45 4.69
36 INT197219 Positive_regulation of Gene_expression of Grik1 5 0.69 0.83 4.67
37 INT24930 Binding of Adrb2 6 0.26 4.18 4.44
38 INT197230 Regulation of Positive_regulation of Grik1 4 0.45 0 4.42
39 INT144428 Positive_regulation of Gene_expression of Erbb2 41 0.69 41.4 4.13
40 INT95512 Transcription of Ghr 24 0.69 3.1 4.12
41 INT4104 Gene_expression of ADRB3 19 0.78 2.68 4.12
42 INT253970 Positive_regulation of Cd74 3 0.48 8.16 4.09
43 INT484 Negative_regulation of ADRB2 13 0.59 2.85 3.94
44 INT109 Binding of ADRB3 17 0.47 3.02 3.84
45 INT152254 Gene_expression of CSF1R 16 0.75 12.93 3.81
46 INT102452 Gene_expression of RAMP2 6 0.69 7.11 3.77
47 INT75485 Gene_expression of Tgfbr2 10 0.57 10.98 3.76
48 INT131969 Regulation of Grik1 6 0.61 0.57 3.69
49 INT46621 Positive_regulation of Gene_expression of CSF1 17 0.47 10.53 3.59
50 INT6882 Binding of Adrb2 5 0.47 1.97 3.55
51 INT40368 Positive_regulation of LRP5 5 0.49 3.19 3.51
52 INT197207 Negative_regulation of Grik1 5 0.43 1.91 3.5
53 INT187168 Binding of Cd74 13 0.27 11.2 3.44
54 INT16626 Positive_regulation of Adrb2 10 0.30 2.41 3.4
55 INT75484 Gene_expression of Tgfbr1 21 0.64 13.36 3.15
56 INT27100 Binding of Adrb3 10 0.47 3.44 3.07
57 INT17389 Negative_regulation of Positive_regulation of Adra2a 6 0.58 0.99 3.06
58 INT59905 Gene_expression of Ghr 29 0.63 9.25 2.97
59 INT41474 Gene_expression of ADRB2 10 0.75 1.56 2.94
60 INT177993 Localization of CSF1R 4 0.73 7.49 2.94
61 INT46620 Positive_regulation of Positive_regulation of CSF1 1 0.12 2.9 2.94
62 INT7931 Positive_regulation of Protein_catabolism of Adra2a 1 0.70 0 2.9
63 INT31923 Positive_regulation of Positive_regulation of Adra2a 7 0.44 1.88 2.89
64 INT148934 Binding of Ramp1 4 0.36 0.94 2.89
65 INT167039 Gene_expression of Cd74 24 0.40 17.12 2.84
66 INT8095 Gene_expression of ERBB3 47 0.77 24.85 2.82
67 INT33480 Gene_expression of Adrb2 4 0.66 1.96 2.77
68 INT95105 Gene_expression of TGFBR2 15 0.64 16.36 2.74
69 INT178002 Positive_regulation of CSF1R 2 0.37 6.52 2.74
70 INT142502 Gene_expression of Ramp1 5 0.67 2.23 2.72
71 INT31451 Negative_regulation of Gene_expression of Adra2a 4 0.43 1.03 2.72
72 INT243350 Binding of CD74 2 0.11 4.86 2.72
73 INT43212 Regulation of Gene_expression of Adra2a 4 0.45 0.24 2.48
74 INT514 Gene_expression of Adrb2 3 0.53 0.23 2.46
75 INT18202 Localization of Adrb3 7 0.80 2.76 2.44
76 INT12456 Negative_regulation of Positive_regulation of Adra2a 4 0.37 1.35 2.42
77 INT22019 Regulation of GHR 9 0.62 2.56 2.39
78 INT57244 Positive_regulation of Caprin2 5 0.13 3.44 2.39
79 INT9764 Gene_expression of Adrb3 10 0.62 4.14 2.33
80 INT16286 Positive_regulation of GHR 8 0.60 4.04 2.31
81 INT67352 Transcription of Ghr 8 0.61 1.55 2.3
82 INT53587 Positive_regulation of Binding of Adra2a 1 0.12 0 2.26
83 INT3531 Regulation of Adrb2 7 0.44 1.48 2.25
84 INT30372 Regulation of ADRB3 8 0.60 0.57 2.24
85 INT34500 Positive_regulation of ADRB3 12 0.58 2.59 2.16
86 INT70725 Negative_regulation of Binding of ADRB2 3 0.57 0.4 2.14
87 INT34196 Regulation of Binding of Adra2a 2 0.45 0 2.12
88 INT95510 Regulation of Ghr 1 0.45 0.21 2.07
89 INT31262 Positive_regulation of Binding of Adra2a 4 0.10 1.02 2.04
90 INT4643 Negative_regulation of GHR 10 0.45 3.01 2
91 INT194414 Positive_regulation of Gene_expression of RAMP1 4 0.60 0.57 1.89
92 INT23426 Regulation of ADRA2A 8 0.48 1.81 1.88
93 INT253975 Binding of Cd74 4 0.27 4.57 1.88
94 INT40832 Localization of ADRB2 5 0.73 2.21 1.81
95 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8
96 INT197209 Positive_regulation of Positive_regulation of Grik1 4 0.50 0.36 1.74
97 INT113676 Gene_expression of NRP1 22 0.72 10.81 1.71
98 INT141967 Gene_expression of RAMP3 4 0.69 3.35 1.69
99 INT21788 Positive_regulation of ERBB2 49 0.66 28.88 1.68
100 INT75316 Gene_expression of Ghr 6 0.78 1.24 1.68
101 INT89467 Gene_expression of Lhcgr 9 0.36 1.59 1.62
102 INT127724 Localization of CSF1 12 0.73 9.35 1.56
103 INT43482 Regulation of Binding of ADRB3 4 0.60 1.06 1.54
104 INT43327 Positive_regulation of ADRA2A 3 0.46 1.54 1.53
105 INT131968 Transcription of Grik1 3 0.51 1.44 1.51
106 INT28300 Gene_expression of GHR 10 0.78 4.29 1.5
107 INT52962 Binding of ERBB2 77 0.47 50.03 1.49
108 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48
109 INT7780 Positive_regulation of Negative_regulation of Adra2a 2 0.50 0.09 1.48
110 INT148933 Localization of Ramp1 1 0.77 0.75 1.48
111 INT168537 Negative_regulation of Gene_expression of Grik1 3 0.57 0.11 1.44
112 INT7932 Protein_catabolism of Adra2a 1 1.00 0 1.44
113 INT67348 Negative_regulation of Ghr 8 0.40 2.84 1.43
114 INT53632 Regulation of Negative_regulation of Adra2a 1 0.23 0.08 1.41
115 INT271443 Regulation of Cd74 1 0.33 2.73 1.4
116 INT5466 Positive_regulation of Negative_regulation of ADRB3 2 0.44 0.17 1.39
117 INT78363 Negative_regulation of Adrb3 2 0.19 3.32 1.38
118 INT29262 Negative_regulation of Binding of Adra2a 4 0.40 0.25 1.37
119 INT166595 Positive_regulation of Binding of RAMP1 2 0.45 0.18 1.36
120 INT96838 Negative_regulation of Gene_expression of ERBB2 25 0.57 15.83 1.34
121 INT75315 Regulation of Ghr 4 0.22 1.5 1.34
122 INT95815 Regulation of Positive_regulation of Adra2a 4 0.45 1.45 1.32
123 INT197224 Negative_regulation of Localization of Grik1 2 0.37 0 1.29
124 INT68471 Negative_regulation of Positive_regulation of Adrb3 1 0.42 0.14 1.29
125 INT7847 Positive_regulation of Localization of Adra2a 2 0.40 0.22 1.28
126 INT57245 Negative_regulation of Positive_regulation of Caprin2 1 0.01 1.03 1.27
127 INT142503 Positive_regulation of Gene_expression of Ramp1 1 0.43 0.83 1.26
128 INT202161 Negative_regulation of CSF1R 3 0.31 3.36 1.22
129 INT79489 Transcription of Adra2a 2 0.61 2.38 1.22
130 INT187835 Gene_expression of Tradd 5 0.53 3.3 1.2
131 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
132 INT310164 Negative_regulation of Gene_expression of Tgfbr1 9 0.40 6.11 1.17
133 INT125676 Positive_regulation of Phosphorylation of Grik1 1 0.01 0 1.17
134 INT161486 Regulation of Ramp1 2 0.61 1.64 1.16
135 INT95511 Negative_regulation of Transcription of Ghr 1 0.43 0 1.15
136 INT62496 Binding of CSF1 6 0.36 4.55 1.14
137 INT110394 Regulation of CSF1R 3 0.38 2.49 1.12
138 INT41475 Positive_regulation of Localization of ADRB2 2 0.49 0.18 1.12
139 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
140 INT61512 Regulation of Binding of GHR 2 0.05 0.89 1.1
141 INT194413 Positive_regulation of RAMP1 1 0.36 0.07 1.08
142 INT293487 Regulation of Gene_expression of Erbb2 4 0.61 3.4 1.06
143 INT284269 Positive_regulation of Negative_regulation of Adrb3 1 0.01 2.42 1.06
144 INT78362 Gene_expression of Adrb3 2 0.67 3.28 1.02
145 INT49796 Positive_regulation of Binding of Adrb2 1 0.00 0 1.02
146 INT52186 Positive_regulation of Positive_regulation of ADRB2 1 0.14 0 1.02
147 INT49795 Negative_regulation of Binding of Adrb2 1 0.00 0 1.02
148 INT12976 Negative_regulation of ADRA2A 4 0.50 0.16 1.01
149 INT95514 Negative_regulation of Ghr 3 0.36 1.3 0.99
150 INT223967 Regulation of Gene_expression of RAMP1 1 0.39 0.5 0.97
151 INT138548 Negative_regulation of Gene_expression of Adrb2 1 0.41 0.85 0.96
152 INT20687 Positive_regulation of Regulation of Adra2a 1 0.35 1.07 0.95
153 INT213917 Negative_regulation of Phosphorylation of ERBB2 9 0.54 8.68 0.91
154 INT95507 Negative_regulation of Gene_expression of Ghr 3 0.33 0.49 0.91
155 INT18801 Negative_regulation of Negative_regulation of Adra2a 2 0.43 0 0.91
156 INT119324 Positive_regulation of Gene_expression of Ramp1 3 0.53 0.94 0.89
157 INT116058 Gene_expression of Cd74 2 0.56 0.55 0.89
158 INT201276 Negative_regulation of Positive_regulation of Grik1 1 0.34 0.3 0.89
159 INT265313 Positive_regulation of Tgfbr1 8 0.66 2.95 0.87
160 INT14976 Negative_regulation of Adrb2 3 0.24 0.75 0.86
161 INT70726 Positive_regulation of Negative_regulation of ADRB2 1 0.49 0.2 0.86
162 INT216456 Positive_regulation of Ghr 6 0.41 4.96 0.85
163 INT42863 Regulation of Adrb2 1 0.11 1.02 0.85
164 INT42862 Regulation of Binding of Adrb2 1 0.15 1.03 0.85
165 INT88718 Negative_regulation of Erbb2 11 0.58 12.98 0.84
166 INT149291 Negative_regulation of NRP1 5 0.40 2.64 0.84
167 INT107939 Regulation of TGFBR2 1 0.37 0.98 0.84
168 INT71649 Localization of ERBB2 23 0.78 13.63 0.83
169 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
170 INT176588 Phosphorylation of ERBB2 27 0.78 16.37 0.81
171 INT72334 Negative_regulation of LRP5 7 0.35 1.71 0.81
172 INT174420 Positive_regulation of Gene_expression of Cd74 3 0.20 1.92 0.81
173 INT174194 Negative_regulation of Gene_expression of CSF1 3 0.33 2.05 0.8
174 INT1852 Localization of ADRB3 3 0.75 1.02 0.79
175 INT14770 Localization of Adra2a 2 0.60 0.1 0.78
176 INT33481 Positive_regulation of Gene_expression of Adrb2 2 0.48 0.38 0.78
177 INT149298 Protein_catabolism of NRP1 2 0.82 1.52 0.77
178 INT161947 Positive_regulation of TGFBR1 2 0.52 1.6 0.76
179 INT18836 Localization of ADRA2A 2 0.38 0.33 0.76
180 INT159982 Negative_regulation of ERBB3 11 0.26 8.44 0.75
181 INT72628 Regulation of CSF1 7 0.25 1.95 0.75
182 INT245584 Positive_regulation of Gene_expression of Ghr 5 0.41 3.46 0.75
183 INT119331 Gene_expression of Ramp2 2 0.60 0.19 0.75
184 INT81396 Regulation of Gene_expression of ERBB2 14 0.43 10.73 0.74
185 INT40369 Gene_expression of LRP5 8 0.55 5.63 0.74
186 INT31778 Negative_regulation of Adrb2 2 0.07 1.34 0.72
187 INT197222 Regulation of Localization of Grik1 1 0.39 0 0.72
188 INT139205 Binding of NRP1 27 0.45 4.34 0.71
189 INT11102 Negative_regulation of Regulation of Adra2a 2 0.42 1.5 0.71
190 INT9980 Positive_regulation of Positive_regulation of Adrb3 2 0.43 0.91 0.71
191 INT197206 Regulation of Gene_expression of Grik1 2 0.39 0.13 0.71
192 INT73783 Regulation of Gene_expression of GHR 1 0.45 0 0.7
193 INT265800 Localization of NRP1 14 0.75 3.66 0.69
194 INT18201 Positive_regulation of Localization of Adrb3 2 0.11 1.2 0.69
195 INT231558 Regulation of LRP5 2 0.24 1.02 0.68
196 INT67452 Positive_regulation of Regulation of ADRB2 1 0.41 0.26 0.68
197 INT33317 Negative_regulation of RIPK1 1 0.31 0.05 0.67
198 INT7609 Regulation of Positive_regulation of Adra2a 3 0.32 0.59 0.66
199 INT203826 Negative_regulation of Tradd 1 0.29 1.46 0.65
200 INT202163 Negative_regulation of Localization of CSF1R 1 0.31 1.76 0.63
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