GO:0043278

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Name response to morphine
Categary Process
Go Slim No
Go Link GO:0043278
Unique Molecular Interactions 1401
Total Molecular Interactions 1936
Total Single Events 19254
Pain Genes Associated 45

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to morphine. They are ordered first by their pain relevance and then by number of times they were reported for response to morphine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
2 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
3 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
4 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
5 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
6 INT143270 Binding of Cnr1 and Gprasp1 4 0.54 0.64 4.18
7 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97
8 INT130625 Prkcg Regulation of Prkaca 1 0.23 1.32 3.87
9 INT115690 Negative_regulation of Prkcg Negative_regulation of Gene_expression of Fos 1 0.47 0.72 3.63
10 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
11 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
12 INT276676 Prkcg Regulation of Nav1 1 0.30 0.82 3.29
13 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
14 INT251146 Binding of Grin1 and Dlg2 1 0.36 1.95 3.16
15 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
16 INT161164 Prkcg Regulation of Phosphorylation of Creb1 3 0.41 0.62 3.11
17 INT101408 Binding of Grin1 and Olr1469 1 0.03 0.86 3.1
18 INT101407 Binding of Grin1 and Spr 1 0.14 0.86 3.09
19 INT276679 Prkcg Positive_regulation of Positive_regulation of Nkx1-1 1 0.07 0.94 3.08
20 INT106338 Positive_regulation of Tacr1 Positive_regulation of Localization of Abat 5 0.34 0 3.01
21 INT102284 Binding of Grin1 and Grin2a 5 0.27 1.79 3.01
22 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
23 INT156381 Binding of Grin1 and Dlg4 1 0.39 0.86 2.9
24 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
25 INT264929 Binding of Cnr1 and Gnaz 1 0.18 1.71 2.89
26 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
27 INT351349 Prkcg Positive_regulation of Binding of Lpar1 1 0.15 2 2.82
28 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79
29 INT351444 Grin1 Positive_regulation of Gria2 1 0.22 1.5 2.64
30 INT121742 Prkcg Positive_regulation of Ephb1 3 0.49 0.99 2.6
31 INT104219 SCD Positive_regulation of Cnr1 1 0.00 2.67 2.54
32 INT143271 Binding of Gprasp1 and Positive_regulation of Negative_regulation of Cnr1 1 0.78 0.16 2.53
33 INT317528 Ppp1r9b Regulation of Grin1 1 0.18 0.2 2.48
34 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
35 INT143272 Binding of CNR1 and Gprasp1 1 0.01 0.17 2.42
36 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
37 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
38 INT198958 Cnr1 Positive_regulation of Kcnj9 1 0.00 0.15 2.24
39 INT317524 Binding of Camk2a and Grin1 1 0.17 0.06 2.21
40 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
41 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
42 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
43 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
44 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
45 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07
46 INT158964 FosB Negative_regulation of Creb1 1 0.21 0 2.07
47 INT117821 Binding of Tacr1 and Cd4 1 0.34 0.86 2.02
48 INT144115 Positive_regulation of Grm5 Positive_regulation of Prkcg 1 0.41 0 2.01
49 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 0.28 1.93 1.93
50 INT107738 Binding of Pld2 and Oprm1 1 0.23 0 1.93
51 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
52 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
53 INT264928 Binding of Cnr1 and Hrh1 1 0.01 1.61 1.92
54 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
55 INT186435 Prkcg Regulation of Creb1 1 0.44 0.45 1.9
56 INT24942 Calca Regulation of TAC1 1 0.13 0.7 1.89
57 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
58 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 0.06 1.02 1.87
59 INT29996 Binding of Oprm1 and Penk 2 0.36 0.4 1.85
60 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
61 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
62 INT276669 Negative_regulation of Prkcg Regulation of Nav1 1 0.21 0.68 1.82
63 INT120732 Prkcg Positive_regulation of Phosphorylation of Grin1 2 0.48 1.04 1.81
64 INT272616 Positive_regulation of Binding of Grin1 and Grin2a 2 0.30 1.36 1.8
65 INT332773 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.04 0.73 1.75
66 INT264922 Binding of Cnr1 and Mors1 1 0.14 0.1 1.71
67 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
68 INT276672 Binding of Prkcg and Nav1 1 0.16 0.18 1.67
69 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
70 INT276680 Binding of Prkcg and Nkx1-1 1 0.05 0.18 1.66
71 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
72 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
73 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
74 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
75 INT23889 Calca Positive_regulation of Localization of Tacr1 1 0.11 0.45 1.65
76 INT169441 TAC1 Positive_regulation of Tac1 1 0.01 1.7 1.64
77 INT147258 Binding of Tac1 and Penk 1 0.35 0 1.64
78 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
79 INT109525 Binding of DMRT1 and Oprm1 1 0.08 0 1.62
80 INT160578 Binding of CALCA and TAC1 1 0.07 0.91 1.61
81 INT131575 Grin1 Negative_regulation of Positive_regulation of Ephb1 1 0.28 0.31 1.58
82 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
83 INT148821 Binding of Oprm1 and Grin1 1 0.05 0.24 1.55
84 INT276671 Prkcg Positive_regulation of Nav1 1 0.23 0.21 1.55
85 INT73016 PDYN Regulation of TAC1 1 0.29 0.34 1.54
86 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
87 INT192081 Igkv11-125 Positive_regulation of Cnr1 1 0.10 0.23 1.51
88 INT121747 Prkcg Negative_regulation of Positive_regulation of Creb1 1 0.16 0.2 1.5
89 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
90 INT72666 Binding of ODT and Oprm1 1 0.03 0.53 1.5
91 INT116094 Binding of TACR1 and TFF2 1 0.06 0 1.47
92 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47
93 INT161865 Mors1 Positive_regulation of Prkcg 1 0.00 0.12 1.47
94 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
95 INT140329 Grin1 Negative_regulation of Ltp 1 0.04 0.64 1.46
96 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
97 INT141673 Oprm1 Positive_regulation of Negative_regulation of Ltp 1 0.13 0 1.46
98 INT141674 Oprm1 Positive_regulation of Ltp 1 0.13 0 1.46
99 INT131039 Binding of Oprm1 and Prf1 1 0.17 0 1.45
100 INT131041 Negative_regulation of Binding of Oprm1 and Prf1 1 0.21 0 1.45
101 INT131040 Binding of Oprm1 and S100a9 1 0.24 0 1.45
102 INT153581 Binding of Oprm1 and Prkcg 1 0.00 0 1.44
103 INT150069 Cnr1 Regulation of Cnr2 2 0.50 0.83 1.42
104 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
105 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
106 INT202910 Uchl1 Positive_regulation of Gene_expression of Tacr1 1 0.05 1.65 1.42
107 INT329451 Binding of Oprd1 and Tacr1 1 0.05 0.23 1.41
108 INT78974 Binding of Prkcg and Prkaca 2 0.31 0.35 1.4
109 INT71543 IFNA1 Negative_regulation of Positive_regulation of TAC1 1 0.20 0.19 1.4
110 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
111 INT293200 Positive_regulation of Grin1 Positive_regulation of Phosphorylation of Grin2b 1 0.24 0.4 1.39
112 INT51160 Binding of TAC1 and Tacr1 2 0.28 0.55 1.38
113 INT139987 Oprm1 Positive_regulation of Localization of Oprl1 1 0.16 0.17 1.35
114 INT15277 Binding of Tac1 and Gal 1 0.39 0.19 1.35
115 INT31772 Ednra Positive_regulation of Nppa 1 0.05 0.13 1.33
116 INT91305 Binding of Npff and Npffr2 2 0.31 0.64 1.32
117 INT131888 gr Positive_regulation of Gene_expression of Prkcg 1 0.00 0 1.32
118 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
119 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
120 INT120929 Prkcg Regulation of Gene_expression of Fos 2 0.50 0.34 1.31
121 INT317519 Grin1 Positive_regulation of Negative_regulation of Oprm1 1 0.14 0 1.31
122 INT355252 Binding of Cacna1a and Cnr1 1 0.04 0 1.31
123 INT198957 Binding of Cnr1 and Mastl 1 0.00 0 1.31
124 INT131886 Creb1 Positive_regulation of Gene_expression of Prkcg 1 0.03 0 1.31
125 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
126 INT192080 Foxm1 Positive_regulation of Cnr1 2 0.14 0.72 1.3
127 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
128 INT49231 TAC1 Negative_regulation of Penk 1 0.00 0 1.3
129 INT95457 Nka1 Positive_regulation of Tacr1 1 0.63 0.29 1.3
130 INT147653 TACR1 Positive_regulation of TRPV1 1 0.02 0.72 1.29
131 INT128310 Oprm1 Positive_regulation of Oprm1 1 0.00 0.1 1.29
132 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28
133 INT89943 Binding of Oprm1 and Il2 1 0.03 0.53 1.28
134 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
135 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27
136 INT64749 Negative_regulation of Binding of Oprm1 and Pck1 1 0.47 0.21 1.27
137 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
138 INT70226 Binding of TAC1 and B3GAT1 4 0.24 4.5 1.26
139 INT126801 Regulation of Binding of Oprm1 and Penk 1 0.34 0.4 1.25
140 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
141 INT76165 IGKV2-30 Positive_regulation of Phosphorylation of Oprm1 1 0.00 0.08 1.22
142 INT76163 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.02 0.08 1.22
143 INT70039 IL1B Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
144 INT70038 IL1B Regulation of PRF1 1 0.05 1.42 1.21
145 INT70031 IL1B Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
146 INT70030 IL1B Regulation of IL10 1 0.07 1.42 1.21
147 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
148 INT210982 Binding of Cnr1 and Cfp 2 0.22 1.27 1.2
149 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2
150 INT63384 Binding of Cnr1 and Insrr 1 0.03 0.24 1.2
151 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
152 INT172500 Ednra Positive_regulation of Coc 1 0.01 1 1.2
153 INT298454 Prkcg Positive_regulation of Phosphorylation of Adarb1 1 0.00 0.41 1.19
154 INT133496 Binding of Oprm1 and Cckbr 1 0.15 0 1.19
155 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18
156 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
157 INT122370 Positive_regulation of Tacr1 Positive_regulation of Ngf 1 0.30 0.17 1.18
158 INT150835 Gper Positive_regulation of Localization of Prkce 1 0.15 0.62 1.18
159 INT85780 Prkaca Regulation of Prkcg 1 0.29 0.47 1.17
160 INT131887 Nr3c1 Regulation of Gene_expression of Prkcg 1 0.01 0 1.17
161 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
162 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
163 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
164 INT212815 WAS Positive_regulation of CNR1 1 0.01 0.62 1.16
165 INT212824 WAS Positive_regulation of Cnr1 1 0.21 0.62 1.16
166 INT94502 Il1b Positive_regulation of Gene_expression of Avp 1 0.28 1.97 1.15
167 INT94509 Il1b Positive_regulation of Gene_expression of AVP 1 0.36 1.96 1.15
168 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
169 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
170 INT122267 Prkcg Positive_regulation of Grin2b 1 0.26 0.61 1.14
171 INT264930 Gnaz Positive_regulation of Negative_regulation of Cnr1 1 0.20 0 1.14
172 INT225104 CNR1 Positive_regulation of Gene_expression of RETNLB 1 0.01 1.41 1.14
173 INT317553 Binding of Car2 and Grin1 1 0.07 0 1.14
174 INT339331 Binding of TACR1 and SFTPA1 1 0.04 0.12 1.14
175 INT122369 Tacr1 Positive_regulation of Ngf 1 0.30 0.16 1.14
176 INT66767 Il1b Positive_regulation of Pla2g10 1 0.05 0.47 1.13
177 INT110671 Binding of Cnr1 and Alox5 1 0.07 0.2 1.13
178 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
179 INT86263 Binding of Tacr3 and Tac2 1 0.16 0.52 1.13
180 INT66907 Il1b Positive_regulation of Localization of Oxt 2 0.78 0.18 1.12
181 INT123454 CNR1 Regulation of Fos 1 0.00 0.06 1.12
182 INT130471 Prkcg Regulation of Regulation of Fos 1 0.45 0.27 1.12
183 INT332776 FSCN1 Positive_regulation of Grin1 1 0.02 0.21 1.12
184 INT123455 CNR1 Regulation of Positive_regulation of Fos 1 0.00 0.06 1.12
185 INT73679 Nkx1-1 Positive_regulation of Tacr3 1 0.22 0.26 1.12
186 INT147660 Positive_regulation of Prkce Positive_regulation of TRPV1 1 0.04 0.69 1.12
187 INT296950 Tacr1 Negative_regulation of Gene_expression of Cck 1 0.30 0.94 1.11
188 INT193328 Grid1 Regulation of Positive_regulation of Prkcg 1 0.00 0.1 1.1
189 INT269191 Binding of Grin1 and Grin3a 2 0.32 1.05 1.09
190 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
191 INT107562 Penk Positive_regulation of Localization of Il1b 1 0.20 0.09 1.09
192 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
193 INT74939 IL1B Positive_regulation of Gene_expression of HGF 1 0.58 0.72 1.09
194 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
195 INT107567 Hps4 Positive_regulation of Localization of Il1b 1 0.01 0.09 1.08
196 INT317561 Binding of Grin1 and Oprm1 1 0.14 0.09 1.08
197 INT96905 Plxna3 Regulation of Regulation of Prkce 1 0.18 0.71 1.07
198 INT107564 Hps4 Regulation of Localization of Il1b 1 0.01 0.1 1.07
199 INT107560 Penk Regulation of Localization of Il1b 1 0.18 0.1 1.07
200 INT77982 Binding of YY1 and Oprm1 2 0.17 0.17 1.06

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to morphine. They are ordered first by their pain relevance and then by number of times they were reported in response to morphine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41
2 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
3 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61
4 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92
5 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47
6 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93
7 INT6042 Binding of Oprm1 248 0.48 31.77 154.34
8 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61
9 INT90910 Phosphorylation of Grin1 150 0.82 68.23 139.24
10 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93
11 INT4824 Positive_regulation of Tacr1 169 0.70 66.1 123.46
12 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38
13 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34
14 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44
15 INT4936 Localization of Tacr1 125 0.80 35.7 107.7
16 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
17 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57
18 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
19 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49
20 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7
21 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63
22 INT4857 Regulation of Tacr1 115 0.62 39.01 84.52
23 INT12536 Localization of Prkcg 101 0.80 36.37 73.81
24 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
25 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
26 INT6849 Localization of IL1B 229 0.81 112.56 69.63
27 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26
28 INT39777 Regulation of Prkcg 90 0.62 31.52 68.17
29 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33
30 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84
31 INT90911 Positive_regulation of Phosphorylation of Grin1 62 0.70 27.45 59.26
32 INT7340 Regulation of Grin1 87 0.62 30.37 57.93
33 INT5017 Negative_regulation of Tacr1 76 0.58 17 57.07
34 INT37219 Gene_expression of TACR1 56 0.78 32.4 54.16
35 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78
36 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21
37 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75
38 INT62630 Positive_regulation of CNR1 86 0.70 40.34 51.51
39 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
40 INT57021 Positive_regulation of Gene_expression of Grin1 62 0.70 24.77 47.31
41 INT4776 Localization of TAC1 82 0.78 16.89 45.21
42 INT63383 Binding of Cnr1 77 0.48 22.28 44.61
43 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
44 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
45 INT16194 Binding of CNR1 82 0.48 20.75 39.59
46 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43
47 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
48 INT4925 Binding of Tacr1 57 0.48 17.39 38.38
49 INT11246 Binding of Grin1 65 0.48 14.53 36.93
50 INT48959 Positive_regulation of Positive_regulation of Prkcg 52 0.70 16.47 36.49
51 INT4843 Gene_expression of Npff 50 0.78 12.92 36.37
52 INT14137 Localization of Oprm1 56 0.81 2.88 36.09
53 INT12608 Regulation of CNR1 62 0.60 24.36 36.02
54 INT8837 Positive_regulation of TAC1 59 0.67 21.94 35.97
55 INT13501 Binding of Drd2 65 0.48 23.76 35.6
56 INT6484 Binding of IL1B 122 0.47 75.84 35.07
57 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76
58 INT4892 Positive_regulation of Gene_expression of Tacr1 56 0.69 25.64 34.69
59 INT12765 Positive_regulation of Phosphorylation of Prkcg 59 0.66 20.16 34.67
60 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52
61 INT21527 Gene_expression of FosB 47 0.78 11.2 34.39
62 INT12537 Positive_regulation of Localization of Prkcg 36 0.70 14.57 33.81
63 INT50308 Binding of Cnr1 61 0.48 14.41 33.52
64 INT48907 Positive_regulation of Gene_expression of Oprm1 53 0.69 8.55 33.52
65 INT51698 Positive_regulation of Gene_expression of Prkcg 44 0.68 14.02 32.9
66 INT4727 Regulation of TAC1 60 0.47 6.74 32.83
67 INT57024 Regulation of Gene_expression of Grin1 32 0.62 9.77 32.6
68 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
69 INT9347 Localization of Il1b 58 0.81 26.13 31.53
70 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
71 INT22239 Negative_regulation of TAC1 52 0.57 12.96 31.41
72 INT9133 Negative_regulation of Positive_regulation of Prkcg 37 0.59 10.95 30.06
73 INT106540 Negative_regulation of Phosphorylation of Grin1 15 0.58 9.32 29.13
74 INT53384 Positive_regulation of FosB 41 0.69 8.43 28.91
75 INT111359 Localization of Cnr1 55 0.81 11.25 27.41
76 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
77 INT75418 Negative_regulation of Cnr1 41 0.59 14.65 27.28
78 INT8881 Regulation of Gene_expression of Tacr1 38 0.61 17.49 27.19
79 INT80470 Negative_regulation of Gene_expression of Grin1 33 0.59 10.22 27.15
80 INT53385 Positive_regulation of Gene_expression of FosB 26 0.70 9.18 26.33
81 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
82 INT11773 Gene_expression of Tac1 56 0.77 10 25.72
83 INT8779 Binding of TAC1 50 0.47 11.19 25.57
84 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
85 INT74377 Regulation of Cnr1 38 0.59 16.93 24.77
86 INT12484 Binding of Drd2 45 0.48 15.17 24.72
87 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
88 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24
89 INT6294 Regulation of Gene_expression of Oprm1 28 0.62 6.77 22.79
90 INT87607 Positive_regulation of Prkcc 25 0.69 6.06 22.78
91 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
92 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21
93 INT49774 Binding of DRD2 48 0.48 17.42 20.73
94 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34
95 INT10442 Negative_regulation of CNR1 47 0.59 20.88 20.2
96 INT4841 Localization of Npff 26 0.80 4.36 19.91
97 INT41494 Negative_regulation of Gene_expression of Tacr1 25 0.58 11.73 19.91
98 INT21105 Phosphorylation of Oprm1 32 0.82 0.83 19.29
99 INT79955 Localization of Cnr1 26 0.81 8.44 19.06
100 INT50420 Transcription of Grin1 30 0.71 13.21 18.28
101 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26
102 INT12360 Regulation of Tac1 31 0.61 5.9 18
103 INT58495 Positive_regulation of Positive_regulation of Oprm1 22 0.49 2.44 17.66
104 INT16155 Positive_regulation of Npff 25 0.70 6.21 17.58
105 INT63928 Negative_regulation of Grin1 51 0.56 11.81 17.57
106 INT6728 Gene_expression of Ednra 43 0.65 13.41 17.38
107 INT36054 Transcription of IL1B 53 0.72 32.64 17.31
108 INT16624 Localization of Grin1 38 0.79 8.46 17.15
109 INT65211 Binding of Prkcg 38 0.48 14.75 16.92
110 INT6043 Negative_regulation of Binding of Oprm1 24 0.57 2.67 16.78
111 INT88356 Negative_regulation of Positive_regulation of Grin1 16 0.58 4.72 16.58
112 INT87932 Positive_regulation of Gene_expression of Cnr1 28 0.69 8.86 16.38
113 INT62629 Localization of CNR1 35 0.76 11.86 16.3
114 INT74545 Negative_regulation of Gene_expression of Prkcg 22 0.42 7.77 16.26
115 INT9525 Regulation of Positive_regulation of Prkcg 20 0.62 7.82 16.18
116 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
117 INT32802 Negative_regulation of Ada 21 0.57 4.03 14.87
118 INT79887 Gene_expression of Prkcc 20 0.78 12.59 14.73
119 INT11980 Positive_regulation of Tac1 27 0.69 6.17 14.5
120 INT25266 Positive_regulation of Localization of IL1B 38 0.69 15.89 14.35
121 INT63854 Regulation of Gene_expression of Prkcg 27 0.56 9.41 14.15
122 INT46582 Binding of Npff 20 0.48 1.49 13.99
123 INT92513 Regulation of Grin1 26 0.59 9.12 13.94
124 INT7342 Positive_regulation of Positive_regulation of Grin1 18 0.50 9.22 13.76
125 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68
126 INT74375 Positive_regulation of Gene_expression of Cnr1 24 0.70 14.25 13.66
127 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63
128 INT4842 Regulation of Npff 13 0.54 4.59 13.62
129 INT68814 Positive_regulation of Transcription of Oprm1 16 0.60 2.72 13.57
130 INT8756 Gene_expression of Tac2 26 0.78 2.64 13.39
131 INT24956 Gene_expression of Tacr3 22 0.74 7.21 13.37
132 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
133 INT119089 Regulation of Phosphorylation of Grin1 17 0.61 3.1 12.82
134 INT49041 Transcription of Tacr1 25 0.72 12.52 12.8
135 INT57580 Positive_regulation of TACR1 18 0.69 9.35 12.47
136 INT69763 Positive_regulation of Positive_regulation of Cnr1 12 0.50 9.05 12.46
137 INT47847 Negative_regulation of Localization of Prkcg 11 0.58 4.02 12.36
138 INT112103 Binding of Grin1 28 0.48 4.21 12.08
139 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
140 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79
141 INT88650 Negative_regulation of Prkce 13 0.57 11.93 11.16
142 INT6044 Regulation of Binding of Oprm1 16 0.61 3.01 11.11
143 INT59766 Positive_regulation of Negative_regulation of Oprm1 9 0.50 1.31 11.08
144 INT8589 Positive_regulation of Positive_regulation of Tacr1 14 0.69 7.85 10.86
145 INT23519 Positive_regulation of Localization of Tacr1 12 0.41 3.84 10.82
146 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
147 INT50196 Transcription of Il1b 25 0.69 19.08 10.43
148 INT71592 Negative_regulation of Gene_expression of Oprm1 11 0.58 4.03 10.37
149 INT91948 Positive_regulation of Prkce 16 0.64 11.36 10.32
150 INT75955 Gene_expression of Drd3 19 0.77 4.39 10.07
151 INT11238 Positive_regulation of ADA 33 0.70 39.7 9.98
152 INT106565 Negative_regulation of Gene_expression of Cnr1 19 0.59 6.98 9.93
153 INT51168 Localization of TACR1 10 0.80 7.66 9.83
154 INT79248 Regulation of Negative_regulation of Prkcg 13 0.44 3.44 9.78
155 INT53547 Binding of TACR1 22 0.48 5.03 9.48
156 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
157 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
158 INT72148 Positive_regulation of Prkce 17 0.68 5.06 9.44
159 INT47845 Regulation of Localization of Prkcg 16 0.62 3.1 9.42
160 INT49483 Regulation of Positive_regulation of Oprm1 8 0.61 2.34 9.4
161 INT71565 Negative_regulation of Prkcc 11 0.54 4.16 9.31
162 INT51837 Negative_regulation of TACR1 17 0.43 6.5 9.12
163 INT10597 Gene_expression of Cyp19a1 27 0.78 7.48 9.11
164 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
165 INT121987 Phosphorylation of Grin1 11 0.80 4.73 8.88
166 INT12358 Regulation of Gene_expression of Tac1 17 0.60 3.34 8.84
167 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
168 INT66213 Localization of RELA 63 0.78 14.71 8.77
169 INT76162 Positive_regulation of Phosphorylation of Oprm1 11 0.69 0.64 8.72
170 INT6727 Positive_regulation of Ednra 27 0.64 18.75 8.71
171 INT81597 Transcription of Npff 10 0.69 5.52 8.53
172 INT18021 Positive_regulation of Binding of Oprm1 16 0.70 2.53 8.38
173 INT81610 Phosphorylation of TACR1 1 0.81 0.76 8.38
174 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34
175 INT4940 Negative_regulation of Localization of Tacr1 8 0.37 4.29 8.25
176 INT30382 Negative_regulation of Ednra 21 0.42 12.06 8.19
177 INT117642 Regulation of Gene_expression of Grin1 18 0.53 7.09 8.08
178 INT77804 Regulation of Ednra 9 0.39 2.71 7.94
179 INT4663 Positive_regulation of Ada 17 0.69 9.48 7.93
180 INT114675 Positive_regulation of Gene_expression of Mdm2 1 0.70 1.98 7.9
181 INT54978 Binding of EDNRA 36 0.41 14.97 7.86
182 INT10444 Positive_regulation of Gene_expression of CNR1 18 0.69 8.69 7.84
183 INT135113 Localization of Grin1 18 0.73 3.73 7.69
184 INT50195 Positive_regulation of Positive_regulation of Il1b 12 0.67 7.41 7.64
185 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
186 INT67170 Gene_expression of Ednra 22 0.65 9.35 7.57
187 INT87976 Regulation of Gene_expression of Cnr1 9 0.58 6.87 7.51
188 INT14548 Localization of Tac1 13 0.78 1.43 7.48
189 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
190 INT110705 Positive_regulation of Positive_regulation of Grin1 11 0.69 4.7 7.33
191 INT99076 Regulation of Gene_expression of FosB 7 0.62 1.34 7.32
192 INT11378 Negative_regulation of Positive_regulation of IL1B 23 0.59 10.28 7.26
193 INT86898 Negative_regulation of Gene_expression of Cnr1 13 0.55 3.33 7.25
194 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
195 INT96969 Positive_regulation of Positive_regulation of CNR1 9 0.48 1.27 7.19
196 INT79247 Negative_regulation of Negative_regulation of Prkcg 11 0.42 1.78 7.13
197 INT110104 Localization of Prkce 17 0.79 3.75 6.92
198 INT16628 Negative_regulation of Positive_regulation of Oprm1 9 0.43 0.89 6.92
199 INT12359 Negative_regulation of Tac1 26 0.58 8.16 6.89
200 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84
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