GO:0043293

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Name apoptosome
Categary Component
Go Slim No
Go Link GO:0043293
Unique Molecular Interactions 43
Total Molecular Interactions 45
Total Single Events 412
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for apoptosome. They are ordered first by their pain relevance and then by number of times they were reported for apoptosome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT129694 Binding of Casp3 and Casp9 1 0.35 0.86 0.65
2 INT181675 Positive_regulation of Casp9 Positive_regulation of Casp3 1 0.06 0.51 0.2
3 INT181677 Casp9 Positive_regulation of Casp3 1 0.06 0.5 0.19
4 INT349538 Smcp Positive_regulation of Positive_regulation of Casp9 1 0.04 0.68 0.18
5 INT96417 CYC1 Positive_regulation of Casp9 1 0.02 0.96 0.17
6 INT130921 HMHA1 Positive_regulation of CASP9 1 0.03 1.37 0.14
7 INT130919 HMHA1 Positive_regulation of Protein_catabolism of CASP9 1 0.03 1.37 0.14
8 INT342309 Apaf1 Positive_regulation of Casp9 1 0.02 1.1 0.13
9 INT193697 Apaf1 Positive_regulation of CASP9 1 0.02 1.84 0.12
10 INT302161 AKT1 Negative_regulation of CASP9 1 0.03 0.87 0.11
11 INT302175 BAX Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
12 INT302155 TP53 Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
13 INT265459 Phosphorylation of TP53 Positive_regulation of Localization of CASP9 1 0.17 1.16 0.05
14 INT265454 Phosphorylation of TP53 Positive_regulation of CASP9 1 0.17 1.16 0.05
15 INT265462 CSPG4 Negative_regulation of Positive_regulation of CASP9 1 0.07 1.2 0.04
16 INT265461 CSPG4 Negative_regulation of Gene_expression of CASP9 1 0.06 1.2 0.04
17 INT201770 Binding of CASP9 and Apaf1 1 0.04 0.89 0.03
18 INT220445 Bcl2 Negative_regulation of Positive_regulation of Casp9 1 0.01 1.37 0.03
19 INT342733 Gene_expression of Lrrk2 Positive_regulation of Apaf1 1 0.10 0.74 0.03
20 INT327981 CASP9 Positive_regulation of CASP3 2 0.29 1.34 0
21 INT279798 APAF1 Positive_regulation of CASP3 1 0.01 1 0
22 INT304170 Binding of Apaf1 and Positive_regulation of Casp9 1 0.01 0.51 0
23 INT322559 TNFSF10 Positive_regulation of CASP9 1 0.03 1.79 0
24 INT200647 HDAC4 Positive_regulation of CASP9 1 0.10 0.93 0
25 INT327978 PNLIP Regulation of Regulation of CASP9 1 0.19 0.57 0
26 INT322561 Negative_regulation of TNFSF10 Positive_regulation of CASP9 1 0.03 1.15 0
27 INT348530 CASP10 Positive_regulation of CASP9 1 0.02 0.3 0
28 INT229824 Fos Regulation of Casp9 1 0.07 0.32 0
29 INT336036 Positive_regulation of CASP9 Positive_regulation of CASP3 1 0.05 0.75 0
30 INT178938 Binding of Casp9 and Apaf1 1 0.01 0.74 0
31 INT336037 CASP8 Positive_regulation of Positive_regulation of CASP9 1 0.01 0.59 0
32 INT348536 Positive_regulation of TP63 Positive_regulation of Gene_expression of CASP9 1 0.02 0.55 0
33 INT201769 Akt1 Negative_regulation of Phosphorylation of CASP9 1 0.00 0.82 0
34 INT327979 Positive_regulation of CASP9 Positive_regulation of Gene_expression of CASP3 1 0.07 0.78 0
35 INT318223 BAX Regulation of CASP9 1 0.09 0.18 0
36 INT200646 AKT1 Regulation of CASP9 1 0.10 1.09 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for apoptosome. They are ordered first by their pain relevance and then by number of times they were reported in apoptosome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT88919 Positive_regulation of Casp9 39 0.70 28.64 8.18
2 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33
3 INT116143 Positive_regulation of Casp9 32 0.67 30.34 3.04
4 INT141180 Gene_expression of Apaf1 6 0.74 5.77 2.98
5 INT141183 Gene_expression of Casp9 9 0.75 11.96 2.46
6 INT129280 Gene_expression of Casp9 9 0.68 5.48 2.25
7 INT151467 Localization of CASP9 9 0.73 7.62 2.04
8 INT141191 Positive_regulation of Gene_expression of Apaf1 1 0.48 2.33 1.85
9 INT122488 Protein_catabolism of CASP9 8 0.46 8.64 1.8
10 INT122487 Positive_regulation of Positive_regulation of CASP9 16 0.67 17.88 1.79
11 INT121964 Positive_regulation of Positive_regulation of Casp9 8 0.32 5.52 1.73
12 INT88916 Negative_regulation of Casp9 5 0.33 3.01 1.67
13 INT88920 Negative_regulation of Positive_regulation of Casp9 7 0.59 5.27 1.57
14 INT141184 Negative_regulation of Casp9 5 0.42 5.48 1.15
15 INT141190 Negative_regulation of Transcription of Casp9 1 0.57 1.42 1.15
16 INT141179 Negative_regulation of Apaf1 2 0.41 1.53 1.14
17 INT141178 Transcription of Casp9 1 0.69 1.42 1.14
18 INT141181 Negative_regulation of Transcription of Apaf1 1 0.40 1.42 1.14
19 INT141182 Transcription of Apaf1 1 0.68 1.41 1.14
20 INT122485 Negative_regulation of CASP9 18 0.46 15.78 1.12
21 INT141187 Positive_regulation of Gene_expression of Casp9 3 0.49 4.2 1
22 INT137503 Positive_regulation of Positive_regulation of Casp9 6 0.67 4.66 0.74
23 INT151466 Binding of CASP9 3 0.36 2.44 0.5
24 INT129281 Positive_regulation of Gene_expression of Casp9 1 0.31 0.84 0.48
25 INT137502 Regulation of Positive_regulation of Casp9 1 0.32 0.52 0.32
26 INT286753 Negative_regulation of Positive_regulation of Apaf1 1 0.09 2.82 0.31
27 INT168388 Negative_regulation of Positive_regulation of Casp9 1 0.20 1.43 0.3
28 INT181665 Localization of Apaf1 2 0.49 1.67 0.23
29 INT292751 Negative_regulation of Localization of CASP9 1 0.41 2.11 0.22
30 INT199843 Protein_catabolism of Casp9 6 0.26 4.5 0.18
31 INT116195 Localization of Casp9 4 0.15 4.33 0.18
32 INT141821 Binding of Casp9 2 0.18 0.58 0.18
33 INT141822 Positive_regulation of Binding of Casp9 1 0.24 0.53 0.18
34 INT125101 Gene_expression of CASP9 24 0.35 16.54 0.17
35 INT165361 Positive_regulation of APAF1 4 0.39 4.8 0.16
36 INT175518 Positive_regulation of Apaf1 3 0.15 2.37 0.15
37 INT206938 Regulation of Casp9 5 0.44 3.99 0.12
38 INT330036 Binding of Apaf1 2 0.25 2.06 0.11
39 INT297723 Negative_regulation of Binding of Casp9 1 0.17 1.18 0.11
40 INT297716 Binding of Casp9 1 0.15 1.18 0.11
41 INT165362 Gene_expression of APAF1 5 0.50 4.37 0.08
42 INT165363 Positive_regulation of Positive_regulation of APAF1 1 0.28 1.12 0.08
43 INT193813 Positive_regulation of Phosphorylation of APAF1 1 0.08 0.41 0.07
44 INT193808 Phosphorylation of APAF1 1 0.13 0.4 0.07
45 INT125103 Positive_regulation of Gene_expression of CASP9 5 0.31 2.52 0.06
46 INT265496 Positive_regulation of Localization of CASP9 2 0.25 1.89 0.05
47 INT199855 Positive_regulation of Protein_catabolism of Casp9 2 0.07 1.63 0.05
48 INT190027 Regulation of Apaf1 2 0.16 2.59 0.04
49 INT204291 Gene_expression of Apaf1 3 0.42 3.31 0.03
50 INT201641 Binding of Apaf1 3 0.16 2.36 0.03
51 INT204285 Positive_regulation of Apaf1 2 0.35 1.87 0.03
52 INT204292 Negative_regulation of Apaf1 1 0.18 0.97 0.03
53 INT204288 Negative_regulation of Negative_regulation of Apaf1 1 0.18 0.98 0.03
54 INT204295 Negative_regulation of Gene_expression of Apaf1 1 0.18 0.97 0.03
55 INT216420 Regulation of Gene_expression of Casp9 1 0.03 0.92 0.03
56 INT265492 Negative_regulation of Positive_regulation of CASP9 4 0.57 3.61 0
57 INT310236 Binding of APAF1 3 0.09 2.67 0
58 INT318238 Regulation of CASP9 2 0.25 1.29 0
59 INT200680 Phosphorylation of CASP9 2 0.25 1.33 0
60 INT308398 Positive_regulation of Gene_expression of APAF1 2 0.39 1.8 0
61 INT229834 Localization of Casp9 2 0.20 1.24 0
62 INT300640 Transcription of CASP9 1 0.23 1.11 0
63 INT322583 Positive_regulation of Protein_catabolism of CASP9 1 0.06 1.14 0
64 INT330037 Regulation of Casp9 1 0.03 0.58 0
65 INT190011 Negative_regulation of Gene_expression of Apaf1 1 0.23 0.76 0
66 INT318229 Regulation of Gene_expression of CASP9 1 0.13 0.18 0
67 INT330040 Regulation of Apaf1 1 0.19 0.58 0
68 INT330031 Positive_regulation of Positive_regulation of Apaf1 1 0.35 0.85 0
69 INT200674 Regulation of Positive_regulation of CASP9 1 0.09 1.24 0
70 INT122484 Negative_regulation of Negative_regulation of CASP9 1 0.34 1.03 0
71 INT330032 Negative_regulation of Gene_expression of Casp9 1 0.05 0.38 0
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