GO:0043303

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Name mast cell degranulation
Categary Process
Go Slim No
Go Link GO:0043303
Unique Molecular Interactions 88
Total Molecular Interactions 114
Total Single Events 687
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for mast cell degranulation. They are ordered first by their pain relevance and then by number of times they were reported for mast cell degranulation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT71069 Oprl1 Regulation of Gene_expression of Tac4 1 0.03 0.13 3.64
2 INT14576 Tac4 Regulation of Penk 1 0.07 0 1.77
3 INT167528 Ppt1 Negative_regulation of Gene_expression of Tac4 1 0.06 0.49 1.39
4 INT70803 Ngf Regulation of Tac4 1 0.06 0.39 0.93
5 INT294906 Binding of Pax3 and Tac4 1 0.01 1.15 0.71
6 INT190178 PIK3CG Regulation of MMP12 1 0.09 0 0.65
7 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64
8 INT117707 Oprm1 Positive_regulation of PIK3CG 1 0.00 0.08 0.6
9 INT337326 PIK3CD Positive_regulation of Localization of ITPR3 1 0.02 0 0.43
10 INT337325 PIK3CD Positive_regulation of Phosphorylation of IL2RG 1 0.00 0 0.43
11 INT337324 PIK3CD Positive_regulation of Gene_expression of ITPR3 1 0.02 0 0.43
12 INT114597 Positive_regulation of Trib3 Regulation of Gene_expression of Tac4 1 0.01 0.09 0.4
13 INT145283 Msr1 Negative_regulation of Tac4 1 0.00 0 0.29
14 INT303948 LEPR Positive_regulation of PIK3CG 1 0.02 0.22 0.28
15 INT121581 Negative_regulation of PIK3CG Positive_regulation of GDF15 1 0.36 0.59 0.24
16 INT55828 Bdnf Negative_regulation of Negative_regulation of Tac4 1 0.09 0 0.21
17 INT298196 EGFR Positive_regulation of PIK3CD 1 0.04 0.65 0.18
18 INT121580 PIK3CG Regulation of Gene_expression of GDF15 1 0.48 0.4 0.18
19 INT265892 IGF1 Positive_regulation of PIK3CG 1 0.18 1.96 0.16
20 INT204790 Binding of Lat2 and Mthfd1 1 0.05 0.85 0.16
21 INT203591 Positive_regulation of PIK3CG Positive_regulation of Protein_catabolism of LAMB2 1 0.00 0.46 0.14
22 INT275983 Binding of Lat and Lcp2 1 0.23 0.41 0.13
23 INT335460 FPR1 Positive_regulation of PIK3CD 1 0.17 0 0.13
24 INT129091 Binding of PIK3CG and Lyn 1 0.00 0.47 0.12
25 INT129073 Binding of GRP and PIK3CG 1 0.00 0.49 0.12
26 INT50903 Ppt1 Regulation of Tac4 1 0.18 0 0.11
27 INT50901 Ppt1 Regulation of Transcription of Tac4 1 0.18 0 0.11
28 INT343855 Binding of MYD88 and PIK3CG 1 0.03 0.26 0.1
29 INT224021 PIK3CG Negative_regulation of EPHB2 1 0.03 0.5 0.09
30 INT328435 PIK3CD Positive_regulation of Gene_expression of VEGFA 1 0.23 0.64 0.09
31 INT348168 Thbs1 Positive_regulation of PIK3CD 1 0.00 0.65 0.07
32 INT302164 PTEN Regulation of PIK3CD 1 0.16 1.13 0.06
33 INT252338 Binding of Cd28 and Lat 1 0.30 0 0.06
34 INT252335 Regulation of Binding of Cd28 and Lat 1 0.37 0 0.06
35 INT328438 PRB4 Negative_regulation of PIK3CD 1 0.06 0.29 0.05
36 INT332286 PIK3CD Positive_regulation of MTOR 1 0.14 0.73 0.03
37 INT328436 PRB4 Negative_regulation of Gene_expression of PIK3CD 1 0.07 0.24 0.03
38 INT328430 PRB4 Regulation of Positive_regulation of PIK3CD 1 0.06 0.4 0.03
39 INT332284 IRS1 Regulation of PIK3CD 1 0.15 0.72 0.03
40 INT321402 Binding of NPHS1 and PIK3CD 1 0.02 0.73 0.03
41 INT265880 IGF1 Regulation of PIK3CG 1 0.10 1.23 0.03
42 INT332288 Positive_regulation of IRS1 Regulation of PIK3CD 1 0.07 0.73 0.03
43 INT176131 Binding of AKT1 and PIK3CG 2 0.15 1.08 0
44 INT342094 Binding of Lat and Ie 1 0.05 1.9 0
45 INT201767 Igf1 Positive_regulation of PIK3CG 1 0.00 0.84 0
46 INT221621 Binding of Lat and Fer 1 0.02 0 0
47 INT342095 Regulation of Binding of Lat and Ie 1 0.07 2.03 0
48 INT322849 Binding of PIK3CD and PDCD10 1 0.16 0 0
49 INT336033 PIK3CG Regulation of AKT1 1 0.03 0.43 0
50 INT328431 PIK3CD Negative_regulation of Gene_expression of VEGFA 1 0.22 0.29 0
51 INT304022 Binding of PIK3CG and TP53 1 0.10 0.72 0
52 INT176137 Negative_regulation of Binding of AKT1 and PIK3CG 1 0.17 0.25 0
53 INT354122 MIR126 Regulation of PIK3CG 1 0.03 2.01 0
54 INT194698 Binding of ZAP70 and LAT 1 0.04 0 0
55 INT322844 Binding of KDR and PIK3CD 1 0.04 0 0
56 INT320712 Binding of NRAS and PIK3CD 1 0.21 1.66 0
57 INT304018 Regulation of Binding of PIK3CG and TP53 1 0.12 0.73 0
58 INT262759 PIK3CG Positive_regulation of MTOR 1 0.38 0.54 0
59 INT275974 Binding of Grb2 and Lat 1 0.33 0 0
60 INT225903 Binding of GAB1 and PIK3CG 1 0.01 0.13 0
61 INT201773 Binding of BCL2L1 and Positive_regulation of Negative_regulation of PIK3CG 1 0.01 0.3 0
62 INT194711 LAT Positive_regulation of Binding of VAV1 1 0.03 0 0
63 INT225876 PIK3CG Positive_regulation of Ilk 1 0.00 0 0
64 INT234970 Binding of Jup and Lat 1 0.01 0 0
65 INT293806 AR Positive_regulation of PIK3CG 1 0.06 0.12 0
66 INT304015 Binding of PIK3CA and PIK3CG 1 0.09 0.67 0
67 INT169882 Rap2ip Positive_regulation of Gene_expression of MILR1 1 0.00 0.11 0
68 INT287269 Binding of ERBB3 and PIK3CG 1 0.11 0.74 0
69 INT194692 Binding of VAV1 and LAT 1 0.02 0 0
70 INT293802 PTEN Regulation of PIK3CG 1 0.03 0.07 0
71 INT328427 PIK3CD Negative_regulation of Phosphorylation of AKT1 1 0.09 0.29 0
72 INT322848 VEGFA Positive_regulation of PIK3CD 1 0.09 0 0
73 INT322843 Positive_regulation of PIK3CD Positive_regulation of Positive_regulation of RHOA 1 0.03 0 0
74 INT320715 NRAS Positive_regulation of PIK3CD 1 0.27 1.66 0
75 INT275977 Lcp2 Positive_regulation of Lat 1 0.30 0 0
76 INT304026 Binding of PIK3CG and PTEN 1 0.11 0.62 0
77 INT223579 PTEN Negative_regulation of PIK3CG 1 0.18 0.56 0
78 INT275982 Grap2 Positive_regulation of Lat 1 0.33 0 0
79 INT234974 Binding of Lat and Dsp 1 0.00 0 0
80 INT293816 Binding of AR and PIK3CG 1 0.03 0.27 0
81 INT225894 Binding of MET and PIK3CG 1 0.00 0.13 0
82 INT201759 Ngf Positive_regulation of PIK3CG 1 0.01 0.84 0
83 INT262753 Binding of MTOR and PIK3CG 1 0.20 0.82 0
84 INT223578 INS Positive_regulation of PIK3CG 1 0.05 0.87 0
85 INT223576 PIK3CG Regulation of MTOR 1 0.15 0.37 0
86 INT275971 Binding of Lat and Grap2 1 0.24 0 0
87 INT223580 Positive_regulation of PIK3CG Regulation of MTOR 1 0.25 0.42 0
88 INT275981 Grb2 Positive_regulation of Lat 1 0.35 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for mast cell degranulation. They are ordered first by their pain relevance and then by number of times they were reported in mast cell degranulation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4887 Gene_expression of Tac4 70 0.77 11.66 40.97
2 INT11979 Transcription of Tac4 42 0.52 4.48 20.95
3 INT11977 Positive_regulation of Tac4 26 0.69 3.91 17.15
4 INT4895 Positive_regulation of Gene_expression of Tac4 16 0.69 2.46 11.51
5 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25
6 INT120401 Positive_regulation of PIK3CD 33 0.45 14.89 7.37
7 INT31361 Regulation of Gene_expression of Tac4 15 0.57 1.07 7.31
8 INT11976 Positive_regulation of Transcription of Tac4 11 0.44 1.57 6.44
9 INT118274 Positive_regulation of Positive_regulation of PIK3CG 8 0.64 4.81 4.62
10 INT50630 Negative_regulation of Tac4 14 0.58 0.34 4.45
11 INT110343 Negative_regulation of PIK3CD 22 0.40 5.84 4.2
12 INT86919 Negative_regulation of PIK3CG 40 0.57 21.16 3.97
13 INT52493 Positive_regulation of Positive_regulation of Tac4 3 0.13 0.45 3.21
14 INT50636 Regulation of Tac4 9 0.53 0.33 3.1
15 INT53069 Regulation of Transcription of Tac4 4 0.23 0.49 2.36
16 INT264967 Positive_regulation of Positive_regulation of PIK3CD 4 0.18 1.97 2.13
17 INT66117 Negative_regulation of MILR1 4 0.37 1.34 2.12
18 INT31360 Negative_regulation of Positive_regulation of Tac4 2 0.55 0 1.81
19 INT60027 Negative_regulation of Gene_expression of Tac4 4 0.58 0.26 1.67
20 INT243799 Gene_expression of PIK3CD 15 0.45 6.63 1.5
21 INT110747 Gene_expression of Tac4 3 0.74 0.42 1.44
22 INT50897 Negative_regulation of Transcription of Tac4 3 0.43 0 1.25
23 INT264969 Localization of PIK3CD 5 0.50 0.64 1.13
24 INT155696 Gene_expression of PIK3CG 16 0.65 8.54 1.02
25 INT60028 Localization of Tac4 2 0.33 0 0.83
26 INT108204 Regulation of PIK3CG 9 0.12 4.16 0.75
27 INT56910 Regulation of Negative_regulation of Tac4 2 0.39 0.24 0.75
28 INT11978 Regulation of Positive_regulation of Tac4 1 0.28 0.46 0.72
29 INT169880 Gene_expression of MILR1 2 0.03 0.41 0.66
30 INT190187 Regulation of Gene_expression of PIK3CG 1 0.13 0 0.65
31 INT64028 Negative_regulation of Negative_regulation of Tac4 2 0.43 0.17 0.64
32 INT264964 Positive_regulation of Localization of PIK3CD 1 0.13 0.05 0.62
33 INT50632 Positive_regulation of Negative_regulation of Tac4 2 0.34 0.1 0.57
34 INT294898 Negative_regulation of Binding of Tac4 1 0.02 1.58 0.57
35 INT294900 Binding of Tac4 1 0.02 1.58 0.55
36 INT150815 Positive_regulation of Lat2 1 0.05 1.61 0.55
37 INT150816 Positive_regulation of Positive_regulation of Lat2 1 0.05 1.62 0.55
38 INT132781 Phosphorylation of PIK3CG 8 0.52 4.83 0.53
39 INT154565 Regulation of Positive_regulation of PIK3CD 2 0.09 1.59 0.45
40 INT98072 Gene_expression of LAT 5 0.68 5.37 0.44
41 INT337345 Regulation of Gene_expression of PIK3CD 1 0.20 0 0.43
42 INT199011 Binding of Lat 11 0.32 6.03 0.42
43 INT337344 Negative_regulation of Negative_regulation of PIK3CD 1 0.19 0 0.4
44 INT132780 Positive_regulation of Phosphorylation of PIK3CG 1 0.01 0.37 0.4
45 INT151632 Binding of Tac4 1 0.02 0.41 0.4
46 INT275954 Regulation of Lat 4 0.54 0.75 0.37
47 INT125798 Localization of MILR1 2 0.14 0.77 0.33
48 INT278559 Regulation of Tac4 1 0.26 0.14 0.26
49 INT187543 Localization of Lat2 2 0.73 0.35 0.24
50 INT176145 Positive_regulation of Gene_expression of PIK3CG 3 0.20 1.36 0.22
51 INT233110 Regulation of Localization of MILR1 1 0.02 0.32 0.19
52 INT270152 Positive_regulation of Lat 6 0.44 11.1 0.16
53 INT302261 Regulation of PIK3CD 7 0.29 5.34 0.15
54 INT47893 Positive_regulation of MILR1 2 0.21 0.06 0.15
55 INT243793 Phosphorylation of PIK3CD 5 0.42 1.74 0.13
56 INT278555 Regulation of Gene_expression of Tac4 1 0.26 0 0.13
57 INT270171 Positive_regulation of Positive_regulation of Lat 2 0.32 1.91 0.12
58 INT204784 Gene_expression of Lat2 6 0.65 2.18 0.11
59 INT278554 Negative_regulation of Gene_expression of Tac4 1 0.41 0 0.09
60 INT98071 Localization of LAT 1 0.62 0.63 0.09
61 INT262775 Negative_regulation of Phosphorylation of PIK3CG 1 0.28 1.1 0.09
62 INT328448 Negative_regulation of Gene_expression of PIK3CD 1 0.21 0.84 0.08
63 INT230866 Negative_regulation of Gene_expression of PIK3CG 2 0.28 1.37 0.07
64 INT275923 Gene_expression of Lat 6 0.59 13.31 0.05
65 INT275933 Negative_regulation of Lat 1 0.51 0.07 0.04
66 INT341853 Negative_regulation of Negative_regulation of PIK3CG 1 0.14 0.85 0.04
67 INT254585 Binding of Lat2 1 0.07 0.44 0.04
68 INT194775 Positive_regulation of Positive_regulation of LAT 1 0.10 0 0.04
69 INT201693 Negative_regulation of Positive_regulation of PIK3CG 1 0.05 1.04 0.04
70 INT176162 Binding of PIK3CG 5 0.15 1.3 0.03
71 INT349238 Negative_regulation of LAT 1 0.23 0.11 0.03
72 INT194788 Positive_regulation of LAT 1 0.10 0 0.03
73 INT320732 Binding of PIK3CD 3 0.20 1.66 0
74 INT176151 Regulation of Negative_regulation of PIK3CG 2 0.28 0.92 0
75 INT275949 Negative_regulation of Positive_regulation of Lat 2 0.37 2.34 0
76 INT221574 Transcription of Lat 2 0.44 1.3 0
77 INT342086 Regulation of Positive_regulation of Lat 1 0.29 1.99 0
78 INT342092 Regulation of Transcription of Lat 1 0.29 0.6 0
79 INT342076 Localization of Lat 1 0.47 2.56 0
80 INT275930 Positive_regulation of Protein_catabolism of Lat 1 0.44 0.12 0
81 INT342083 Negative_regulation of Binding of Lat 1 0.27 0.78 0
82 INT275948 Regulation of Protein_catabolism of Lat 1 0.39 0.12 0
83 INT311855 Regulation of Negative_regulation of PIK3CD 1 0.04 0.28 0
84 INT342088 Negative_regulation of Localization of Lat 1 0.27 1.61 0
85 INT275934 Regulation of Binding of Lat 1 0.34 0 0
86 INT349232 Positive_regulation of Gene_expression of LAT 1 0.27 0.99 0
87 INT342080 Positive_regulation of Transcription of Lat 1 0.32 0.32 0
88 INT349231 Negative_regulation of Gene_expression of LAT 1 0.23 0.58 0
89 INT193985 Regulation of Phosphorylation of PIK3CG 1 0.03 0.32 0
90 INT317150 Positive_regulation of Gene_expression of Lat2 1 0.49 0.34 0
91 INT342081 Positive_regulation of Localization of Lat 1 0.32 0.56 0
92 INT342084 Negative_regulation of Transcription of Lat 1 0.27 0.72 0
93 INT176159 Regulation of Positive_regulation of PIK3CG 1 0.18 0.21 0
94 INT265697 Negative_regulation of Gene_expression of Lat2 1 0.14 0.17 0
95 INT342077 Positive_regulation of Gene_expression of Lat 1 0.32 3.58 0
96 INT275958 Protein_catabolism of Lat 1 0.77 0.12 0
97 INT169879 Regulation of MILR1 1 0.02 0.33 0
98 INT278553 Transcription of Tac4 1 0.51 0 0
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