GO:0043306

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Name positive regulation of mast cell degranulation
Categary Process
Go Slim No
Go Link GO:0043306
Unique Molecular Interactions 110
Total Molecular Interactions 160
Total Single Events 904
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of mast cell degranulation. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of mast cell degranulation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
2 INT107738 Binding of Pld2 and Oprm1 1 0.23 0 1.93
3 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 0.02 0.36 1.5
4 INT356317 Crhr1 Regulation of Gene_expression of Cea 1 0.18 0.65 1.33
5 INT356326 Crhr1 Regulation of Gene_expression of Helt 1 0.01 0.65 1.32
6 INT162165 WDTC1 Positive_regulation of PLD2 1 0.50 0 1.25
7 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
8 INT209088 Binding of Ceacam3 and Crhr1 1 0.34 1.26 1.11
9 INT216736 Binding of ADORA2B and ATP6V0A1 2 0.08 0.06 0.93
10 INT72917 Binding of Crh and Crhr1 4 0.32 0.73 0.91
11 INT194856 Positive_regulation of Adora2b Negative_regulation of Positive_regulation of Mmp13 1 0.01 0.73 0.85
12 INT252455 Binding of Adora2b and SLURP1 1 0.02 0.6 0.81
13 INT107739 Prkcg Negative_regulation of Positive_regulation of Pld2 1 0.46 0 0.79
14 INT162164 ARF6 Regulation of Positive_regulation of PLD2 1 0.60 0 0.74
15 INT290548 Positive_regulation of Crhr1 Positive_regulation of Etf1 1 0.01 0.38 0.72
16 INT107741 Binding of OPRM1 and Pld2 1 0.01 0 0.69
17 INT122190 Binding of Crhr1 and Ucn 4 0.49 0.65 0.67
18 INT134286 PLD2 Regulation of Regulation of EDNRA 1 0.10 0 0.67
19 INT134287 PLD2 Regulation of Regulation of MRGPRX1 1 0.31 0 0.67
20 INT356329 Crhr1 Regulation of Cea 1 0.09 0.31 0.64
21 INT356314 Binding of Crhr1 and ORF61 1 0.00 0 0.63
22 INT160880 Pld2 Positive_regulation of Oprm1 1 0.07 0.08 0.63
23 INT160882 Pld2 Positive_regulation of Gene_expression of Oprm1 1 0.06 0.08 0.63
24 INT308803 Binding of Pld1 and Pld2 1 0.13 1.11 0.59
25 INT356321 Positive_regulation of Crhr1 Positive_regulation of Cea 1 0.19 0.37 0.56
26 INT356322 Positive_regulation of Crhr1 Positive_regulation of ORF61 1 0.00 0 0.54
27 INT130161 IgG-2a Positive_regulation of Gene_expression of Crhr1 1 0.01 0 0.52
28 INT130158 Pomc Regulation of Gene_expression of Crhr1 1 0.20 0 0.52
29 INT130163 Pomc Positive_regulation of Gene_expression of Crhr1 1 0.15 0 0.52
30 INT130159 IgG-2a Regulation of Gene_expression of Crhr1 1 0.01 0 0.52
31 INT205030 Crh Positive_regulation of Crhr1 2 0.54 1.33 0.51
32 INT160881 Positive_regulation of Oprm1 Positive_regulation of Positive_regulation of Pld2 1 0.05 0.08 0.48
33 INT233503 Tlr4 Positive_regulation of Adora2b 1 0.06 0.45 0.47
34 INT216737 Binding of ADORA2B and TCFL5 1 0.03 0.05 0.39
35 INT122189 Binding of Crhr1 and Ucn2 2 0.08 0.27 0.36
36 INT254123 Binding of Adora2b and Rai1 1 0.24 0.75 0.35
37 INT252453 Binding of AR and Adora2b 1 0.05 0 0.35
38 INT59602 Crhr1 Positive_regulation of Localization of LH 1 0.25 0 0.33
39 INT356323 Binding of ac and Crhr1 1 0.01 0 0.32
40 INT241739 Sdhb Regulation of Adora2b 1 0.04 0.63 0.31
41 INT126696 Binding of Crhr1 and Crh 3 0.50 0.44 0.29
42 INT264782 Binding of CRH and CRHR1 1 0.02 0.06 0.28
43 INT215653 Binding of Adora1 and Adora3 1 0.39 0.07 0.27
44 INT280811 Binding of Crhr1 and Ucn3 1 0.08 0.05 0.25
45 INT302818 Gcat Negative_regulation of Syk 1 0.00 0.53 0.24
46 INT252456 IGKV2D-29 Regulation of Gene_expression of Adora2b 1 0.07 0 0.24
47 INT224135 Binding of ARRB2 and Adora2b 1 0.14 0.07 0.23
48 INT224133 Negative_regulation of Adora2b Positive_regulation of ADCY1 1 0.01 0.1 0.2
49 INT224134 Adora2b Positive_regulation of ADCY1 1 0.01 0.1 0.2
50 INT226542 Negative_regulation of Adora2b Positive_regulation of IL19 1 0.08 0.58 0.2
51 INT226525 Adora2b Positive_regulation of IL19 1 0.03 0.58 0.2
52 INT153322 CRH Positive_regulation of Positive_regulation of CRHR1 1 0.31 0.12 0.19
53 INT252454 Negative_regulation of Binding of Adora2b and SLURP1 1 0.02 0.33 0.16
54 INT224136 ARRB2 Positive_regulation of Adora2b 1 0.19 0 0.16
55 INT278373 Myd88 Regulation of Phosphorylation of Syk 1 0.15 0.35 0.15
56 INT224132 ARRB2 Negative_regulation of Positive_regulation of Adora2b 1 0.14 0.28 0.15
57 INT224127 Grk5 Positive_regulation of Phosphorylation of Adora3 1 0.06 0 0.13
58 INT224125 Adrbk2 Positive_regulation of Phosphorylation of Adora3 1 0.04 0 0.13
59 INT317774 CRHR1 Positive_regulation of Localization of POMC 1 0.05 0.55 0.11
60 INT275451 Binding of ZAP70 and Syk 1 0.02 0.12 0.1
61 INT275450 Binding of STAM and Syk 1 0.00 0.12 0.1
62 INT241741 Sdhb Positive_regulation of Transcription of Adora2b 1 0.07 0.28 0.08
63 INT338429 Il9 Positive_regulation of Gene_expression of Fcer1a 1 0.05 0.31 0.07
64 INT202546 Binding of FCER1A and IGHE 1 0.02 0.49 0.04
65 INT205032 Crh Regulation of Crhr1 1 0.21 0.84 0.03
66 INT278404 Syk Positive_regulation of Mapk1 1 0.13 0 0
67 INT278400 Negative_regulation of Syk Negative_regulation of Positive_regulation of Hps5 1 0.16 0 0
68 INT278382 Binding of Syk and Nlrp3 1 0.24 0 0
69 INT278401 Syk Regulation of Positive_regulation of Hps5 1 0.19 0 0
70 INT326898 Positive_regulation of Tcf4 Regulation of PLD2 1 0.26 0.33 0
71 INT278410 Gopc Positive_regulation of Phosphorylation of Syk 1 0.10 0.23 0
72 INT326899 Tcf4 Positive_regulation of PLD2 1 0.28 0.49 0
73 INT222502 Binding of Crhr1 and Ucn2 1 0.01 0.05 0
74 INT326836 Binding of HNF4A and PLD2 1 0.03 0.35 0
75 INT326895 Binding of PLD2 and Tcf4 1 0.27 0.39 0
76 INT278387 Syk Regulation of Positive_regulation of Il1 1 0.06 0 0
77 INT326900 Tcf4 Regulation of PLD2 1 0.15 0.33 0
78 INT326896 Wnt3a Positive_regulation of Transcription of PLD2 1 0.24 0.06 0
79 INT278372 Binding of Syk and Pycard 1 0.06 0 0
80 INT278399 Syk Positive_regulation of Localization of Ctsb 1 0.09 0.28 0
81 INT200817 Akt1 Positive_regulation of Negative_regulation of Fgr 1 0.25 1.02 0
82 INT278405 Tlr4 Positive_regulation of Syk 1 0.06 0 0
83 INT209444 Stam Positive_regulation of Syk 1 0.01 0.26 0
84 INT278392 Syk Regulation of Positive_regulation of Ctsb 1 0.06 0 0
85 INT326901 Binding of PLD2 and Pld1 1 0.28 0.46 0
86 INT327809 Binding of ADORA2B and IL8 1 0.03 0.3 0
87 INT278396 Msu Positive_regulation of Phosphorylation of Syk 1 0.25 0.27 0
88 INT154173 Binding of SIPA1 and SYK 1 0.16 0.46 0
89 INT278380 Syk Positive_regulation of Pik3r1 1 0.13 0 0
90 INT326897 Tcf4 Positive_regulation of Gene_expression of PLD2 1 0.26 0.41 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of mast cell degranulation. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of mast cell degranulation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT125947 Gene_expression of Adora2b 57 0.75 23.69 17
2 INT9751 Localization of Crhr1 26 0.78 10.47 15.69
3 INT216751 Gene_expression of ADORA2B 36 0.60 3.42 15.6
4 INT194850 Positive_regulation of Adora2b 43 0.61 20.57 13.89
5 INT104039 Positive_regulation of Crhr1 15 0.70 8.34 10.99
6 INT7572 Regulation of Crhr1 8 0.45 5.6 8.93
7 INT7570 Transcription of Crhr1 7 0.66 6.6 7.6
8 INT74326 Gene_expression of Crhr1 25 0.66 9.7 7.48
9 INT216752 Binding of ADORA2B 17 0.36 0.76 7.36
10 INT80161 Positive_regulation of Crhr1 13 0.67 9.66 7.33
11 INT9753 Positive_regulation of Localization of Crhr1 8 0.49 1.72 6.55
12 INT107737 Positive_regulation of Pld2 11 0.67 0.33 6.45
13 INT134290 Positive_regulation of PLD2 10 0.68 3.06 6.44
14 INT85655 Gene_expression of Crhr1 17 0.68 9.34 6.31
15 INT111384 Gene_expression of Adora3 18 0.75 10.53 5.73
16 INT216840 Binding of Adora2b 3 0.47 5.23 4.85
17 INT18245 Negative_regulation of Localization of Crhr1 4 0.17 0.28 4.81
18 INT7568 Negative_regulation of Crhr1 8 0.43 4.63 4.77
19 INT115805 Gene_expression of PLD2 7 0.76 12.49 4.51
20 INT224046 Negative_regulation of Adora2b 9 0.43 4 3.6
21 INT85537 Regulation of Crhr1 4 0.45 1.64 3.53
22 INT12388 Negative_regulation of Crhr1 17 0.59 9.47 3.33
23 INT127336 Positive_regulation of Transcription of Crhr1 3 0.48 3.37 3.19
24 INT115806 Positive_regulation of Gene_expression of PLD2 5 0.57 7.12 3.11
25 INT9752 Regulation of Localization of Crhr1 3 0.44 0.36 2.82
26 INT111385 Negative_regulation of Adora3 7 0.43 3.91 2.8
27 INT224047 Regulation of Adora2b 7 0.27 3.23 2.12
28 INT278340 Gene_expression of Syk 7 0.51 4.92 2.09
29 INT216839 Positive_regulation of Positive_regulation of Adora2b 5 0.45 2.27 2
30 INT52523 Positive_regulation of Adora3 2 0.49 1.39 1.79
31 INT216749 Positive_regulation of ADORA2B 6 0.37 0.89 1.72
32 INT224049 Transcription of Adora2b 6 0.69 5.12 1.67
33 INT216847 Transcription of ADORA2B 1 0.51 0.93 1.55
34 INT205025 Positive_regulation of Positive_regulation of Crhr1 2 0.70 1.22 1.51
35 INT29667 Positive_regulation of CRHR1 6 0.54 1.09 1.5
36 INT93792 Binding of Crhr1 4 0.48 1.32 1.49
37 INT107735 Positive_regulation of Positive_regulation of Pld2 3 0.48 0 1.47
38 INT115807 Negative_regulation of PLD2 3 0.57 0.69 1.43
39 INT112934 Binding of Crhr1 7 0.46 2.69 1.39
40 INT194849 Negative_regulation of Gene_expression of Adora3 2 0.18 2.08 1.29
41 INT107732 Gene_expression of Pld2 1 0.75 0 1.25
42 INT140887 Binding of CRHR1 2 0.34 0.26 1.22
43 INT241724 Localization of Adora2b 2 0.75 1.21 1.14
44 INT224042 Phosphorylation of Adora2b 1 0.29 0.25 1.08
45 INT52524 Regulation of Adora3 3 0.44 1.17 0.96
46 INT275940 Negative_regulation of Syk 3 0.39 2.08 0.95
47 INT217050 Positive_regulation of Gene_expression of Adora2b 3 0.50 1.19 0.92
48 INT162169 Negative_regulation of Positive_regulation of PLD2 1 0.56 0 0.92
49 INT126572 Positive_regulation of SYK 3 0.67 2.98 0.83
50 INT74324 Positive_regulation of Gene_expression of Crhr1 6 0.49 2.91 0.79
51 INT77256 Negative_regulation of Gene_expression of Crhr1 5 0.40 2.52 0.77
52 INT108044 Phosphorylation of Syk 3 0.25 1.39 0.77
53 INT194851 Protein_catabolism of Adora2b 1 0.17 0.6 0.75
54 INT290527 Positive_regulation of Localization of Crhr1 1 0.37 1.4 0.74
55 INT290534 Localization of Crhr1 1 0.56 1.4 0.74
56 INT162170 Regulation of Positive_regulation of PLD2 1 0.26 0 0.74
57 INT107736 Positive_regulation of Gene_expression of Pld2 1 0.67 0 0.74
58 INT117245 Gene_expression of CRHR1 3 0.51 3.45 0.73
59 INT241715 Negative_regulation of Gene_expression of Adora2b 2 0.43 0.48 0.73
60 INT7567 Negative_regulation of Transcription of Crhr1 1 0.37 0.48 0.71
61 INT215602 Localization of Adora3 2 0.73 0.63 0.7
62 INT252430 Negative_regulation of Binding of Adora2b 1 0.26 0.27 0.65
63 INT216750 Positive_regulation of Gene_expression of ADORA2B 1 0.34 0 0.64
64 INT216761 Positive_regulation of Binding of ADORA2B 1 0.34 0 0.63
65 INT134289 Positive_regulation of Positive_regulation of PLD2 2 0.46 0 0.6
66 INT224056 Regulation of Gene_expression of Adora2b 2 0.27 0.12 0.59
67 INT132324 Localization of SYK 2 0.78 1.9 0.59
68 INT7563 Regulation of Transcription of Crhr1 1 0.17 0.59 0.59
69 INT278152 Negative_regulation of Syk 1 0.24 1.93 0.59
70 INT308802 Binding of Pld2 1 0.13 1.11 0.59
71 INT132325 Positive_regulation of Localization of SYK 1 0.49 0.56 0.54
72 INT115803 Regulation of PLD2 1 0.44 0.43 0.53
73 INT154180 Negative_regulation of SYK 3 0.43 4.67 0.5
74 INT356301 Negative_regulation of Positive_regulation of Crhr1 1 0.19 0.44 0.5
75 INT216757 Protein_catabolism of ADORA2B 1 0.67 0 0.5
76 INT302775 Negative_regulation of Gene_expression of Syk 1 0.27 0.84 0.48
77 INT216753 Regulation of Binding of ADORA2B 1 0.18 0 0.48
78 INT154182 Phosphorylation of SYK 6 0.82 5.54 0.43
79 INT216855 Negative_regulation of ADORA2B 1 0.32 0.05 0.43
80 INT224043 Phosphorylation of Adora3 1 0.15 0.2 0.43
81 INT143392 Transcription of Crhr1 1 0.61 0.38 0.43
82 INT154181 Positive_regulation of Phosphorylation of SYK 4 0.70 4.71 0.37
83 INT221086 Negative_regulation of CRHR1 3 0.31 0.71 0.37
84 INT252432 Positive_regulation of Localization of Adora2b 1 0.30 0.06 0.37
85 INT121505 Regulation of Regulation of Crhr1 1 0.43 0.33 0.35
86 INT252431 Negative_regulation of Positive_regulation of Adora2b 1 0.26 0.76 0.35
87 INT154175 Regulation of SYK 2 0.62 1.48 0.34
88 INT153296 Regulation of Gene_expression of Crhr1 2 0.39 0.72 0.34
89 INT215609 Transcription of Adora3 2 0.62 0.35 0.31
90 INT108043 Negative_regulation of Phosphorylation of Syk 1 0.13 0.53 0.31
91 INT154559 Positive_regulation of Syk 2 0.20 0.74 0.3
92 INT308793 Gene_expression of Pld2 9 0.32 0.51 0.27
93 INT247098 Localization of CRHR1 3 0.68 1.45 0.27
94 INT278155 Regulation of Negative_regulation of Syk 1 0.18 0.55 0.26
95 INT303591 Positive_regulation of Gene_expression of Crhr1 2 0.42 0.34 0.25
96 INT252723 Gene_expression of SYK 3 0.25 2.67 0.23
97 INT278154 Regulation of Syk 1 0.05 0.98 0.22
98 INT278147 Localization of Syk 1 0.30 0.98 0.22
99 INT224051 Regulation of Phosphorylation of Adora2b 1 0.09 0.09 0.18
100 INT224055 Negative_regulation of Phosphorylation of Adora2b 1 0.15 0 0.16
101 INT224054 Positive_regulation of Phosphorylation of Adora2b 1 0.17 0 0.16
102 INT275937 Phosphorylation of Syk 3 0.54 1.67 0.15
103 INT154177 Negative_regulation of Phosphorylation of SYK 1 0.43 1.51 0.14
104 INT93793 Positive_regulation of Binding of Crhr1 1 0.48 0.34 0.13
105 INT224050 Negative_regulation of Phosphorylation of Adora3 1 0.10 0.08 0.11
106 INT224044 Regulation of Regulation of Adora3 1 0.06 0.09 0.11
107 INT275411 Binding of Syk 1 0.09 0.12 0.1
108 INT252433 Regulation of Positive_regulation of Adora2b 1 0.44 0 0.09
109 INT199076 Positive_regulation of Syk 3 0.31 0.12 0.07
110 INT133448 Gene_expression of Fcer1a 2 0.17 0.47 0.07
111 INT241734 Regulation of Transcription of Adora3 1 0.39 0.27 0.07
112 INT165757 Positive_regulation of Positive_regulation of Crhr1 1 0.29 0.6 0.07
113 INT241716 Positive_regulation of Transcription of Adora2b 1 0.50 0.28 0.06
114 INT215605 Positive_regulation of Localization of Adora3 1 0.49 0 0.05
115 INT308794 Positive_regulation of Gene_expression of Pld2 2 0.17 0.07 0.04
116 INT278363 Binding of Syk 1 0.32 0.3 0.04
117 INT326879 Binding of PLD2 1 0.31 2.21 0.04
118 INT276348 Positive_regulation of Positive_regulation of SYK 1 0.22 0.66 0.04
119 INT276371 Positive_regulation of Gene_expression of SYK 1 0.22 0.67 0.03
120 INT343071 Negative_regulation of Gene_expression of Pld2 1 0.18 0.1 0
121 INT154178 Binding of SYK 1 0.37 0.46 0
122 INT133447 Positive_regulation of Fcer1a 1 0.01 0.19 0
123 INT278354 Positive_regulation of Phosphorylation of Syk 1 0.31 0.23 0
124 INT275951 Negative_regulation of Phosphorylation of Syk 1 0.34 0.2 0
125 INT133445 Negative_regulation of Gene_expression of Fcer1a 1 0.01 0.16 0
126 INT326876 Transcription of PLD2 1 0.57 0.27 0
127 INT326873 Regulation of Transcription of PLD2 1 0.37 0.22 0
128 INT278348 Positive_regulation of Gene_expression of Syk 1 0.33 0 0
129 INT278326 Regulation of Positive_regulation of Syk 1 0.18 0 0
130 INT200787 Negative_regulation of Fgr 1 0.52 1.01 0
131 INT200794 Gene_expression of Fgr 1 0.54 1.18 0
132 INT205028 Regulation of Gene_expression of Crhr1 1 0.45 0.97 0
133 INT327819 Localization of ADORA2B 1 0.22 0.3 0
134 INT194939 Regulation of Phosphorylation of SYK 1 0.18 0.31 0
135 INT326871 Regulation of Gene_expression of PLD2 1 0.37 1.28 0
136 INT326880 Negative_regulation of Gene_expression of PLD2 1 0.35 1.19 0
137 INT156795 Gene_expression of FCER1A 1 0.31 0 0
138 INT343074 Positive_regulation of Pld2 1 0.17 0 0
139 INT205026 Regulation of Negative_regulation of Crhr1 1 0.45 0.72 0
140 INT278346 Positive_regulation of Negative_regulation of Syk 1 0.33 0 0
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