GO:0043325

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Name phosphatidylinositol-3,4-bisphosphate binding
Categary Function
Go Slim No
Go Link GO:0043325
Unique Molecular Interactions 597
Total Molecular Interactions 828
Total Single Events 5518
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for phosphatidylinositol-3,4-bisphosphate binding. They are ordered first by their pain relevance and then by number of times they were reported for phosphatidylinositol-3,4-bisphosphate binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
2 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
3 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
4 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
5 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
6 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
7 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
8 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
9 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
10 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
11 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
12 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
13 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
14 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
15 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
16 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
17 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
18 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
19 INT124918 Binding of PLEK and Maob 1 0.10 1.05 0.98
20 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
21 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
22 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
23 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
24 INT249012 Binding of Akt1 and Gabrg1 1 0.01 0 0.9
25 INT132226 Binding of Akt1 and Pik3cg 1 0.30 0.49 0.9
26 INT199109 Binding of Akt1 and Arhgdia 1 0.02 2.73 0.87
27 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
28 INT317556 Phosphorylation of Gopc Positive_regulation of Akt1 1 0.10 0.08 0.82
29 INT317514 Akt1 Regulation of Localization of Oprm1 1 0.21 0.07 0.82
30 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
31 INT111888 Akt1 Regulation of Regulation of Oprm1 1 0.04 0 0.77
32 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
33 INT335592 Ltp Positive_regulation of Positive_regulation of Akt1 1 0.01 0.19 0.74
34 INT106527 Akt1 Positive_regulation of Jun 1 0.05 0.53 0.74
35 INT259556 PLEK Negative_regulation of Gene_expression of VEGFA 1 0.46 2.15 0.73
36 INT259557 PLEK Negative_regulation of Positive_regulation of VEGFA 1 0.46 2.15 0.73
37 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
38 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
39 INT298728 Akt1 Positive_regulation of Rela 1 0.01 1.03 0.67
40 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
41 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
42 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
43 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
44 INT169293 PTPLA Positive_regulation of AKT1 1 0.10 0.15 0.64
45 INT134047 Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
46 INT134044 Positive_regulation of Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
47 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62
48 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61
49 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61
50 INT139901 Ins1 Positive_regulation of Akt1 9 0.31 4.58 0.6
51 INT248994 Binding of Akt1 and Ptar1 1 0.00 0 0.58
52 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
53 INT302832 Tnfsf10 Positive_regulation of Akt1 1 0.04 1.63 0.56
54 INT201944 CXCL10 Positive_regulation of Phosphorylation of AKT1 1 0.09 0.79 0.55
55 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
56 INT282284 Cpox Positive_regulation of Akt1 1 0.02 0.47 0.54
57 INT282282 Ptger2 Positive_regulation of Akt1 1 0.03 0.47 0.54
58 INT162994 Binding of Akt1 and Trib3 1 0.04 0.09 0.54
59 INT127320 Gpx3 Regulation of Akt1 2 0.00 3.11 0.53
60 INT317523 Oprm1 Positive_regulation of Gene_expression of Akt1 1 0.32 0.05 0.53
61 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
62 INT317574 Oprm1 Positive_regulation of Akt1 1 0.22 0.05 0.52
63 INT97952 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of AKT1 1 0.03 0.72 0.51
64 INT151221 Negative_regulation of SIGMAR1 Negative_regulation of Akt1 1 0.00 0.13 0.51
65 INT97951 ST3GAL3 Positive_regulation of AKT1 1 0.04 0.7 0.5
66 INT102844 Pdc Regulation of Akt1 1 0.03 0 0.49
67 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
68 INT309126 Edc4 Positive_regulation of Akt1 1 0.02 0.99 0.47
69 INT309144 Dlat Positive_regulation of Akt1 1 0.03 0.99 0.47
70 INT276207 Binding of Akt1 and Myo1f 1 0.11 0.05 0.47
71 INT162932 TXNRD1 Negative_regulation of Phosphorylation of AKT1 1 0.14 1.01 0.47
72 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
73 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
74 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 0.41 1 0.46
75 INT139900 Kcne2 Positive_regulation of Akt1 1 0.06 2.95 0.44
76 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
77 INT348785 Ins1 Positive_regulation of Phosphorylation of Akt1 1 0.17 3.5 0.42
78 INT322396 Hist1h1t Positive_regulation of Akt1 1 0.01 0 0.42
79 INT160048 INPPL1 Regulation of Gene_expression of AKT1 1 0.28 0.6 0.42
80 INT322395 Akt1 Regulation of Pik3cb 1 0.08 0 0.42
81 INT121851 AKT1 Regulation of ROS1 1 0.16 0.52 0.41
82 INT122749 Cyp3a23/3a1 Positive_regulation of Phosphorylation of Akt1 1 0.07 0.24 0.41
83 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
84 INT121854 AKT1 Regulation of BID 1 0.17 0.52 0.41
85 INT276216 Binding of Akt1 and Ins1 2 0.03 2.61 0.4
86 INT108197 AKT1 Regulation of JUN 1 0.29 0.25 0.4
87 INT231842 Pcdh8 Positive_regulation of Akt1 1 0.00 1.59 0.4
88 INT121853 Gene_expression of ROS1 Negative_regulation of AKT1 1 0.25 0.49 0.4
89 INT322409 Positive_regulation of OPRM1 Positive_regulation of Phosphorylation of Akt1 1 0.04 0 0.4
90 INT166155 Ccr9 Positive_regulation of Akt1 1 0.58 2.14 0.39
91 INT310600 Tbxa2r Positive_regulation of PLEK 1 0.53 0.45 0.38
92 INT139566 Binding of PLEK and Tbxa2r 1 0.01 1.14 0.38
93 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37
94 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
95 INT299288 AKT1 Positive_regulation of RPTOR 1 0.34 0.05 0.36
96 INT148243 Binding of Akt1 and Kit 1 0.03 0.44 0.35
97 INT122758 Positive_regulation of Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
98 INT288208 Binding of Mapk14 and Positive_regulation of Akt1 1 0.01 0.42 0.35
99 INT176135 AKT1 Regulation of Localization of CYCS 1 0.43 2.16 0.35
100 INT122756 Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
101 INT309118 Dlat Positive_regulation of Positive_regulation of Akt1 1 0.03 0.32 0.34
102 INT249019 Gabrg1 Positive_regulation of Akt1 1 0.02 0 0.34
103 INT196820 Negative_regulation of Ppp1cc Positive_regulation of Akt1 1 0.00 0 0.34
104 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
105 INT214377 Akt1 Regulation of Amph 1 0.15 0 0.33
106 INT165580 Binding of Akt1 and Grin2b 1 0.02 0.2 0.32
107 INT337410 AKT3 Negative_regulation of AKT1 1 0.09 0.49 0.32
108 INT337414 AKT2 Negative_regulation of AKT1 1 0.10 0.5 0.32
109 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
110 INT303063 Akt1 Negative_regulation of Gene_expression of Syn1 1 0.09 0.45 0.31
111 INT165921 Tlr4 Positive_regulation of Akt1 1 0.16 0.75 0.31
112 INT165920 Negative_regulation of Tlr4 Positive_regulation of Akt1 1 0.13 0.75 0.31
113 INT299307 AKT1 Positive_regulation of Positive_regulation of AKT1S1 1 0.10 0 0.3
114 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
115 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29
116 INT291202 Positive_regulation of INS Positive_regulation of AKT1 1 0.01 0.76 0.29
117 INT132367 Lgals1 Positive_regulation of Akt1 1 0.22 0.13 0.28
118 INT317533 Akt1 Positive_regulation of Nos1 1 0.43 0 0.28
119 INT149322 Amph Positive_regulation of Akt1 1 0.39 0 0.27
120 INT223930 Binding of Akt1 and Pik3cb 1 0.07 0.35 0.26
121 INT223929 Negative_regulation of Binding of Akt1 and Pik3cb 1 0.08 0.36 0.26
122 INT303082 Akt1 Negative_regulation of Gene_expression of Mafk 1 0.20 0.37 0.26
123 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25
124 INT314047 THL Negative_regulation of Phosphorylation of Akt1 1 0.14 0.71 0.25
125 INT326094 Akt1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.49 0.24
126 INT326092 Gene_expression of Akt1 Negative_regulation of Gopc 1 0.03 0.55 0.24
127 INT326093 Akt1 Positive_regulation of Gopc 1 0.03 0.43 0.23
128 INT265886 IGF1 Positive_regulation of AKT1 1 0.11 3.06 0.23
129 INT323173 THRA Positive_regulation of Phosphorylation of Akt1 1 0.00 0 0.22
130 INT260844 NRP2 Positive_regulation of Akt1 1 0.00 0.73 0.22
131 INT116467 Vegfa Positive_regulation of Akt1 1 0.33 1.41 0.21
132 INT323174 DBT Positive_regulation of Phosphorylation of Akt1 1 0.01 0 0.21
133 INT120716 Binding of AKT1 and TEP1 1 0.05 0.46 0.21
134 INT116468 VEGFA Positive_regulation of Akt1 1 0.04 1.39 0.21
135 INT289356 Binding of Akt1 and Fgf2 1 0.03 0.82 0.21
136 INT309661 C5 Positive_regulation of Phosphorylation of Akt1 1 0.51 0.45 0.21
137 INT221237 Prkca Regulation of Phosphorylation of Akt1 1 0.01 0.28 0.2
138 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
139 INT139565 Negative_regulation of Binding of PLEK and Tbxa2r 1 0.01 0.57 0.19
140 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18
141 INT303058 Akt1 Negative_regulation of Gene_expression of Syt1 1 0.21 0.43 0.18
142 INT221231 Pdpk1 Positive_regulation of Akt1 1 0.09 0.13 0.18
143 INT221244 Pdpk1 Positive_regulation of Phosphorylation of Akt1 1 0.09 0.13 0.18
144 INT298192 EGFR Positive_regulation of AKT1 1 0.10 0.65 0.18
145 INT121582 AKT1 Regulation of Gene_expression of GDF15 1 0.21 0.4 0.18
146 INT318324 Binding of AKT1 and PRKCA 1 0.03 0.63 0.18
147 INT253129 Ins1 Regulation of Phosphorylation of Akt1 3 0.11 1.66 0.17
148 INT176133 AKT1 Regulation of BCL2 2 0.12 1.84 0.17
149 INT179841 Il11 Regulation of Positive_regulation of Akt1 1 0.08 0.07 0.17
150 INT105334 PTGER1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.66 0.17
151 INT282858 Bpifa2 Negative_regulation of Akt1 1 0.05 0.91 0.17
152 INT176134 AKT1 Regulation of Gene_expression of BIRC3 1 0.08 1.09 0.17
153 INT226209 Pik3cb Positive_regulation of Phosphorylation of Akt1 1 0.10 1.16 0.17
154 INT282861 Bpifa2 Negative_regulation of Phosphorylation of Akt1 1 0.05 0.91 0.17
155 INT218937 Akt1 Positive_regulation of Parn 1 0.01 0.65 0.16
156 INT316484 Akt1 Positive_regulation of Positive_regulation of Stat3 1 0.01 0.87 0.16
157 INT343475 Epo Regulation of Akt1 1 0.18 0.41 0.16
158 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
159 INT343478 Epo Regulation of Gene_expression of Akt1 1 0.40 0.41 0.16
160 INT218930 Akt1 Positive_regulation of Xiap 1 0.06 0.64 0.16
161 INT224697 TNF Positive_regulation of Akt1 1 0.01 0 0.15
162 INT293698 Positive_regulation of Binding of Akt1 and Plek 1 0.05 0.12 0.15
163 INT292750 Akt1 Positive_regulation of Bcl2 1 0.01 1.67 0.15
164 INT293695 Binding of Akt1 and Plek 1 0.03 0.12 0.15
165 INT292749 Akt1 Positive_regulation of Ctnnd2 1 0.09 1.73 0.15
166 INT231844 Pcdh8 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.63 0.15
167 INT224694 Il1 Positive_regulation of Akt1 1 0.01 0 0.15
168 INT293699 Regulation of Binding of Akt1 and Plek 1 0.04 0.12 0.15
169 INT292748 Akt1 Negative_regulation of Positive_regulation of Casp3 1 0.01 1.81 0.15
170 INT213005 Hdl1 Positive_regulation of Akt1 3 0.19 3.81 0.14
171 INT253122 Ins1 Positive_regulation of Akt1 2 0.15 1.81 0.14
172 INT231274 Nrg1 Regulation of Gene_expression of Akt1 1 0.19 0 0.14
173 INT226205 Negative_regulation of Akt1 Positive_regulation of Casp3 1 0.04 0.71 0.14
174 INT249829 CHI3L1 Positive_regulation of AKT1 1 0.47 0.69 0.14
175 INT298639 GDE1 Negative_regulation of AKT1 1 0.00 1.14 0.14
176 INT355226 VEGFA Positive_regulation of Akt1 1 0.04 0.27 0.14
177 INT293697 Dock2 Positive_regulation of Akt1 1 0.14 0.08 0.13
178 INT252336 Il2 Positive_regulation of Akt1 1 0.01 0 0.13
179 INT263321 Akt1 Regulation of Bad 1 0.00 0.74 0.13
180 INT282862 Bpifa2 Negative_regulation of Positive_regulation of Akt1 1 0.05 0.75 0.13
181 INT182478 Binding of Akt1 and Cx3cr1 1 0.11 0.12 0.13
182 INT320765 Dsg2 Positive_regulation of Akt1 1 0.48 0.74 0.13
183 INT263318 Akt1 Regulation of Gsk3b 1 0.02 0.75 0.13
184 INT293696 Mthfd1 Positive_regulation of Akt1 1 0.05 0.08 0.13
185 INT302156 AKT1 Positive_regulation of E2F2 1 0.02 0.88 0.13
186 INT224685 L1cam Positive_regulation of Positive_regulation of Akt1 1 0.01 0.34 0.13
187 INT182477 Binding of Akt1 and Cxcr4 1 0.10 0.12 0.13
188 INT221254 Binding of KNG1 and Akt1 1 0.00 0.13 0.13
189 INT182483 Cxcr6 Positive_regulation of Akt1 1 0.22 0.12 0.12
190 INT299310 RPTOR Positive_regulation of AKT1 1 0.30 0 0.12
191 INT317891 Binding of Akt1 and Mtf1 1 0.21 1.04 0.11
192 INT256544 Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
193 INT105338 Prkaca Positive_regulation of AKT1 1 0.04 0.93 0.11
194 INT303085 Akt1 Regulation of Gene_expression of Mafk 1 0.12 0.33 0.11
195 INT289765 Akt1 Regulation of Phosphorylation of Gsk3a 1 0.05 0.45 0.11
196 INT240941 Binding of Akt1 and Ins1 1 0.06 0.75 0.11
197 INT163817 Lep Positive_regulation of Phosphorylation of Akt1 1 0.33 0.31 0.11
198 INT289768 Akt1 Regulation of Phosphorylation of Gsk3b 1 0.04 0.45 0.11
199 INT317898 Binding of Akt1 and Eef1a1 1 0.01 1.04 0.11
200 INT265919 Binding of PLEK and Adp 1 0.01 0.38 0.11

Single Events

The table below shows the top 100 pain related interactions that have been reported for phosphatidylinositol-3,4-bisphosphate binding. They are ordered first by their pain relevance and then by number of times they were reported in phosphatidylinositol-3,4-bisphosphate binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
2 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
3 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
4 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
5 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
6 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
7 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52
8 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
9 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
10 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
11 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
12 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
13 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
14 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
15 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
16 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47
17 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
18 INT18412 Binding of PLEK 49 0.47 17.82 10.72
19 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
20 INT3366 Localization of PLEK 44 0.78 15.83 9.55
21 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
22 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
23 INT10969 Positive_regulation of PLEK 33 0.67 16.96 8.35
24 INT12975 Regulation of PLEK 21 0.60 13.62 8.28
25 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83
26 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39
27 INT126748 Positive_regulation of Positive_regulation of Akt1 26 0.55 11.15 7.08
28 INT117721 Positive_regulation of Gene_expression of Akt1 22 0.69 6.26 6.08
29 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06
30 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
31 INT134657 Localization of Akt1 37 0.68 11.58 4.62
32 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44
33 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
34 INT75136 Binding of Akt1 27 0.27 8.81 4.15
35 INT139898 Negative_regulation of Positive_regulation of Akt1 15 0.42 4.66 4.06
36 INT132223 Negative_regulation of Negative_regulation of Akt1 6 0.42 2.75 3.66
37 INT136692 Localization of Akt1 12 0.78 2.14 3.65
38 INT157687 Regulation of Gene_expression of Akt1 9 0.62 4.96 3.27
39 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19
40 INT117720 Negative_regulation of Gene_expression of Akt1 11 0.37 2.33 3.08
41 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02
42 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8
43 INT117715 Regulation of Phosphorylation of Akt1 15 0.51 3.23 2.78
44 INT214355 Binding of Akt1 13 0.36 3.72 2.59
45 INT30001 Negative_regulation of Gene_expression of PLEK 8 0.57 3.31 2.47
46 INT118791 Binding of AKT1 32 0.48 15.51 2.25
47 INT138286 Regulation of Positive_regulation of Akt1 13 0.45 4.93 2.22
48 INT101866 Positive_regulation of Gene_expression of AKT1 49 0.52 17.47 2.14
49 INT123130 Positive_regulation of Positive_regulation of AKT1 22 0.49 11.77 1.83
50 INT142236 Regulation of Phosphorylation of Akt1 13 0.61 5.02 1.75
51 INT165332 Negative_regulation of Negative_regulation of Akt1 5 0.42 3.27 1.7
52 INT33393 Positive_regulation of Gene_expression of PLEK 9 0.67 7.35 1.65
53 INT117714 Regulation of Positive_regulation of Akt1 3 0.61 0.44 1.61
54 INT80086 Regulation of Gene_expression of PLEK 5 0.60 2.79 1.29
55 INT167409 Regulation of Gene_expression of AKT1 8 0.56 4.86 1.23
56 INT135556 Localization of AKT1 38 0.69 12.78 1.17
57 INT118792 Regulation of Positive_regulation of AKT1 8 0.61 3.73 1.15
58 INT176147 Regulation of Phosphorylation of AKT1 14 0.41 6.41 1.13
59 INT30002 Negative_regulation of Negative_regulation of PLEK 3 0.42 0.76 1.12
60 INT207203 Transcription of Akt1 6 0.67 3.73 1.1
61 INT191050 Positive_regulation of Negative_regulation of Akt1 6 0.31 1.82 1.03
62 INT134660 Positive_regulation of Localization of Akt1 10 0.32 6.33 0.94
63 INT163508 Regulation of Gene_expression of Akt1 3 0.45 1.65 0.92
64 INT81220 Negative_regulation of Binding of PLEK 5 0.42 2.03 0.84
65 INT36881 Regulation of Positive_regulation of PLEK 2 0.44 1.77 0.84
66 INT18413 Positive_regulation of Binding of PLEK 3 0.49 1.06 0.77
67 INT3368 Positive_regulation of Localization of PLEK 3 0.45 0.51 0.77
68 INT151170 Regulation of Regulation of Akt1 2 0.45 3.28 0.73
69 INT299338 Negative_regulation of Regulation of AKT1 2 0.31 2.32 0.68
70 INT207204 Regulation of Transcription of Akt1 3 0.35 1.41 0.66
71 INT166024 Protein_catabolism of AKT1 5 0.46 2.6 0.64
72 INT281466 Negative_regulation of Regulation of Akt1 1 0.33 0.31 0.63
73 INT42121 Negative_regulation of Localization of PLEK 4 0.42 1.92 0.61
74 INT123131 Negative_regulation of Negative_regulation of AKT1 6 0.42 3.23 0.58
75 INT45916 Regulation of Negative_regulation of PLEK 1 0.44 0 0.54
76 INT218900 Regulation of Negative_regulation of Akt1 3 0.15 1.73 0.53
77 INT3367 Regulation of Localization of PLEK 1 0.44 0.34 0.52
78 INT276189 Regulation of Localization of Akt1 1 0.43 0.2 0.5
79 INT182136 Regulation of Regulation of PLEK 1 0.44 0.4 0.44
80 INT323021 Positive_regulation of Regulation of PLEK 1 0.49 0.58 0.37
81 INT44345 Positive_regulation of Negative_regulation of PLEK 1 0.45 0.05 0.35
82 INT321348 Positive_regulation of Localization of Akt1 1 0.30 0.08 0.32
83 INT19700 Positive_regulation of Protein_catabolism of PLEK 1 0.49 0.59 0.3
84 INT19699 Protein_catabolism of PLEK 1 0.86 0.58 0.29
85 INT239464 Regulation of Negative_regulation of Akt1 3 0.31 0.37 0.25
86 INT42592 Negative_regulation of Transcription of PLEK 1 0.41 0 0.21
87 INT200666 Transcription of AKT1 8 0.66 4.23 0.2
88 INT230483 Protein_catabolism of Akt1 2 0.10 1.11 0.2
89 INT42593 Transcription of PLEK 1 0.67 0 0.2
90 INT276192 Transcription of Akt1 1 0.66 0.47 0.18
91 INT108192 Regulation of Binding of PLEK 1 0.60 0.17 0.17
92 INT176153 Regulation of Negative_regulation of AKT1 3 0.39 2.13 0.16
93 INT135557 Positive_regulation of Localization of AKT1 3 0.46 0.49 0.15
94 INT226185 Protein_catabolism of Akt1 7 0.53 2.43 0.14
95 INT302248 Negative_regulation of Binding of AKT1 2 0.25 1 0.14
96 INT16719 Positive_regulation of Positive_regulation of PLEK 1 0.45 0.13 0.14
97 INT285902 Positive_regulation of Transcription of AKT1 1 0.06 0.6 0.13
98 INT214360 Negative_regulation of Binding of Akt1 2 0.41 0.09 0.12
99 INT355216 Positive_regulation of Binding of Akt1 1 0.37 0.35 0.12
100 INT199082 Positive_regulation of Binding of Akt1 4 0.17 1.25 0.11
101 INT192239 Positive_regulation of Binding of AKT1 2 0.26 0.91 0.08
102 INT307475 Positive_regulation of Negative_regulation of Akt1 1 0.12 0.12 0.07
103 INT182302 Negative_regulation of Localization of AKT1 5 0.39 3.52 0.06
104 INT300989 Positive_regulation of Negative_regulation of AKT1 2 0.41 1.27 0.03
105 INT288183 Positive_regulation of Regulation of Akt1 1 0.05 0.06 0.03
106 INT268244 Negative_regulation of Localization of Akt1 2 0.28 2 0
107 INT293479 Positive_regulation of Protein_catabolism of Akt1 1 0.26 0.53 0
108 INT180099 Binding of Plek 1 0.02 0 0
109 INT340543 Regulation of Binding of Akt1 1 0.23 0.18 0
110 INT230480 Positive_regulation of Protein_catabolism of Akt1 1 0.06 0.75 0
111 INT198028 Regulation of Regulation of AKT1 1 0.22 1.08 0
112 INT223603 Regulation of Localization of AKT1 1 0.23 0.65 0
113 INT200688 Negative_regulation of Transcription of AKT1 1 0.54 1.53 0
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