GO:0043388

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Name positive regulation of DNA binding
Categary Process
Go Slim No
Go Link GO:0043388
Unique Molecular Interactions 1142
Total Molecular Interactions 1714
Total Single Events 8897
Pain Genes Associated 34

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of DNA binding. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of DNA binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
2 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
3 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
4 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
5 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
6 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
7 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17
8 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
9 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
10 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
11 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
12 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
13 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
14 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
15 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
16 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
17 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29
18 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
19 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
20 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
21 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
22 INT220751 EGF Regulation of GOPC 1 0.08 0 1.18
23 INT220752 Negative_regulation of EGF Regulation of NAV1 1 0.26 0 1.18
24 INT220753 Negative_regulation of EGF Regulation of GOPC 1 0.08 0 1.18
25 INT220748 EGF Regulation of NAV1 1 0.28 0 1.17
26 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
27 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
28 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
29 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
30 INT136989 EGF Negative_regulation of Positive_regulation of KCNJ2 1 0.04 1.09 1.1
31 INT167426 Tlr4 Positive_regulation of Localization of Gpt 1 0.25 1.26 1.1
32 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
33 INT130657 Negative_regulation of Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
34 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
35 INT136988 EGF Negative_regulation of KCNJ2 1 0.04 1.09 1.04
36 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03
37 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
38 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
39 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
40 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
41 INT145163 Tlr4 Positive_regulation of Localization of Nsfl1c 1 0.02 0.43 0.94
42 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
43 INT336017 Vip Regulation of Tlr4 1 0.22 1.23 0.93
44 INT72386 Egf Positive_regulation of Phosphorylation of Shc1 1 0.09 0.18 0.93
45 INT306327 Binding of Ly96 and Tlr4 1 0.10 1.83 0.91
46 INT343909 IgG Positive_regulation of Gene_expression of TLR4 1 0.04 3.49 0.91
47 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
48 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9
49 INT220744 EGF Positive_regulation of Gene_expression of KRT20 1 0.01 1.26 0.9
50 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
51 INT168281 Tlr4 Positive_regulation of Phosphorylation of Mapk4 1 0.06 1.05 0.89
52 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
53 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
54 INT244323 Csf2 Positive_regulation of Gene_expression of Tlr4 1 0.23 1.93 0.85
55 INT100283 TXN Negative_regulation of Gene_expression of POMC 1 0.54 0.5 0.85
56 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83
57 INT220739 EGF Positive_regulation of Transcription of NAV1 1 0.31 0.16 0.83
58 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
59 INT84039 EGF Positive_regulation of Gene_expression of CPOX 2 0.11 1.88 0.8
60 INT84040 EGF Positive_regulation of CPOX 2 0.07 1.91 0.8
61 INT220747 Binding of PCa and EGF 1 0.05 1.42 0.8
62 INT42797 Egf Regulation of Gene_expression of Penk 1 0.21 0.07 0.8
63 INT108331 EGF Positive_regulation of Phosphorylation of BAD 1 0.49 6.72 0.8
64 INT223753 Tlr4 Positive_regulation of Gene_expression of Il10 4 0.32 1.93 0.78
65 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
66 INT339495 Tlr4 Positive_regulation of Eif2ak2 1 0.21 0.58 0.77
67 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
68 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76
69 INT231031 Egf Positive_regulation of Sec22b 1 0.03 0.05 0.76
70 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
71 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
72 INT266408 Binding of HMGB1 and Ager 1 0.01 2.57 0.76
73 INT284306 Tlr4 Positive_regulation of Adrb3 1 0.00 1.19 0.74
74 INT220746 EGF Positive_regulation of Gene_expression of GOPC 1 0.13 0 0.72
75 INT222432 Binding of Tlr4 and Cd14 1 0.02 0.74 0.71
76 INT89936 Tlr4 Positive_regulation of Il6 3 0.49 0.95 0.7
77 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69
78 INT215098 Tlr4 Positive_regulation of Localization of Il6 3 0.18 1.18 0.69
79 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69
80 INT280951 Tlr4 Positive_regulation of Localization of S100a8 1 0.01 1.09 0.69
81 INT253759 Hmgb1 Positive_regulation of Apex1 1 0.09 4.53 0.69
82 INT215093 Tlr4 Positive_regulation of Localization of Hmgb1 1 0.32 2.9 0.68
83 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
84 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66
85 INT306020 Binding of LBP and Tlr4 1 0.13 0.34 0.66
86 INT120144 Negative_regulation of Tlr4 Positive_regulation of Tnf 1 0.18 0.91 0.66
87 INT343851 Positive_regulation of Binding of IRF6 and TLR4 1 0.07 1.96 0.66
88 INT45369 IGF1 Regulation of GH1 1 0.04 1.12 0.65
89 INT244320 Tlr4 Positive_regulation of Aliq1 3 0.04 4.51 0.64
90 INT122823 ERCC2 Regulation of Negative_regulation of OPRM1 1 0.23 0.17 0.63
91 INT339393 Tlr4 Positive_regulation of Nfkb1 1 0.24 2.06 0.61
92 INT169287 EGF Positive_regulation of Localization of IL8 1 0.15 0.13 0.61
93 INT169294 EGF Positive_regulation of Localization of IL6 1 0.18 0.13 0.61
94 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6
95 INT276603 Il10 Positive_regulation of Gene_expression of Tlr4 1 0.12 0.49 0.6
96 INT140264 Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
97 INT140263 Negative_regulation of Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
98 INT275552 Tlr4 Positive_regulation of Gene_expression of Il1 1 0.00 1.28 0.59
99 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 0.10 3.53 0.58
100 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
101 INT100225 Binding of Egf and Src 1 0.01 0.67 0.58
102 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
103 INT212813 Tlr4 Positive_regulation of Nos2 3 0.34 0.89 0.57
104 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
105 INT199976 EGF Regulation of ITGB3BP 1 0.02 0.77 0.57
106 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
107 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 0.01 1.17 0.57
108 INT306330 Cd14 Positive_regulation of Gene_expression of Tlr4 1 0.48 0.54 0.57
109 INT192291 OR5A1 Positive_regulation of Gene_expression of IGF1 1 0.02 0.93 0.57
110 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
111 INT146871 Tlr4 Positive_regulation of Gene_expression of ROS1 2 0.00 1.16 0.56
112 INT141362 EP300 Negative_regulation of Transcription of IL2 1 0.17 0 0.56
113 INT81303 Tlr4 Positive_regulation of Gene_expression of Hmox1 1 0.03 0.55 0.56
114 INT94745 Tlr4 Positive_regulation of Transcription of Il1b 1 0.15 0.48 0.56
115 INT175323 Tlr4 Positive_regulation of Gene_expression of TLR2 1 0.02 0.31 0.56
116 INT150291 Grk1 Positive_regulation of Gene_expression of Igf1 1 0.16 0.98 0.55
117 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
118 INT121993 Binding of EGF and SGCG 1 0.40 0 0.55
119 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
120 INT323611 Il1 Regulation of Hmgb1 1 0.17 2.36 0.55
121 INT167651 Binding of Oprd1 and Ep300 1 0.02 0.09 0.55
122 INT120143 Tlr4 Negative_regulation of Gene_expression of Tnf 1 0.18 0.76 0.55
123 INT243056 Binding of LBP and Tlr4 1 0.00 1.11 0.55
124 INT215101 Hmgb1 Positive_regulation of Localization of Il6 4 0.16 1.18 0.54
125 INT310767 Tlr4 Regulation of Gene_expression of S100a8 1 0.02 0.7 0.54
126 INT210934 Gene_expression of Tlr4 Negative_regulation of Ccl2 1 0.47 0.69 0.54
127 INT354367 Binding of FGFR1 and Tlr4 1 0.01 1.23 0.53
128 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52
129 INT179503 Cd14 Regulation of Positive_regulation of Tlr4 1 0.38 0.58 0.52
130 INT220745 EGF Positive_regulation of Positive_regulation of PCa 1 0.05 0.79 0.52
131 INT142882 IGF1 Positive_regulation of Gene_expression of TRPV1 1 0.06 0.57 0.52
132 INT343838 EDA Positive_regulation of TLR4 1 0.11 0.87 0.51
133 INT285911 Binding of TLR4 and Cd14 1 0.05 1.13 0.51
134 INT324523 Tlr4 Regulation of Gene_expression of PGE 1 0.23 1.98 0.51
135 INT167652 Binding of Ep300 and Ngf 1 0.09 0.06 0.51
136 INT167655 Binding of Polr2f and Ep300 1 0.01 0.06 0.51
137 INT98735 Src Negative_regulation of Egf 1 0.26 0.15 0.5
138 INT179507 Tlr4 Positive_regulation of Tlr2 2 0.17 1.07 0.49
139 INT306019 Binding of Tlr4 and LY96 1 0.06 0.91 0.49
140 INT254119 Binding of Bcl2a1a and Tlr4 1 0.01 1.34 0.49
141 INT98734 Egf Negative_regulation of Tk1 1 0.13 0.15 0.49
142 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 0.08 0.71 0.49
143 INT295708 Binding of EGF and CCL2 1 0.01 0.79 0.49
144 INT108329 EGF Positive_regulation of Phosphorylation of EPHB2 4 0.48 3.96 0.48
145 INT108568 Calca Positive_regulation of Igf1 1 0.51 0.08 0.48
146 INT210160 Binding of TNFRSF8 and TXN 1 0.47 4.16 0.48
147 INT209046 Slc11a1 Positive_regulation of Regulation of Tlr4 1 0.07 0.09 0.48
148 INT244319 Csf2 Positive_regulation of Positive_regulation of Tlr4 1 0.23 1.03 0.48
149 INT322264 Binding of MPZ and TLR4 1 0.18 1.68 0.47
150 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
151 INT233527 Tlr4 Positive_regulation of ADORA1 1 0.00 0.45 0.47
152 INT134045 Jak2 Regulation of Stat3 1 0.26 0.13 0.47
153 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
154 INT173475 Bcar1 Regulation of Isl1 1 0.01 0 0.47
155 INT233503 Tlr4 Positive_regulation of Adora2b 1 0.06 0.45 0.47
156 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
157 INT284300 Tlr4 Positive_regulation of Gene_expression of Mir155 1 0.18 0.91 0.47
158 INT134050 Positive_regulation of Jak2 Regulation of Stat3 1 0.44 0.13 0.47
159 INT246938 Binding of Tlr4 and Tlr2 3 0.39 2.88 0.46
160 INT207141 Tlr4 Positive_regulation of Positive_regulation of Pawr 1 0.05 0.79 0.46
161 INT233508 Tlr4 Regulation of Gene_expression of Gpr18 1 0.04 0.45 0.46
162 INT310769 Pam Regulation of Tlr4 1 0.01 0.69 0.46
163 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45
164 INT195552 Binding of Rela and Ep300 1 0.03 0.2 0.45
165 INT195554 Binding of Nfkb1 and Ep300 1 0.08 0.2 0.45
166 INT335850 Snrpc Negative_regulation of Gene_expression of Isl1 1 0.00 1.51 0.45
167 INT264295 Binding of DMD and IGF1 1 0.07 1.38 0.44
168 INT69163 Tlr4 Positive_regulation of Ptgs1 1 0.02 0.08 0.44
169 INT295406 Egf Regulation of Gene_expression of Oprk1 1 0.01 0.72 0.43
170 INT311590 EGF Regulation of Gene_expression of CXCL10 1 0.23 0.51 0.43
171 INT311589 EGF Regulation of Gene_expression of VEGFA 1 0.18 0.51 0.43
172 INT212810 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.03 0.74 0.43
173 INT100282 TXN Negative_regulation of Transcription of POMC 1 0.54 0.39 0.43
174 INT311591 CXCL10 Regulation of Gene_expression of EGF 1 0.23 0.51 0.43
175 INT13281 Egf Regulation of Ngf 1 0.66 0.12 0.42
176 INT247599 Tlr4 Positive_regulation of Gene_expression of App 1 0.17 0.39 0.42
177 INT308696 Binding of Tlr4 and Tlr4 1 0.00 0.34 0.42
178 INT13279 Ngf Regulation of Egf 1 0.49 0.12 0.42
179 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41
180 INT336926 Mir341 Regulation of Tlr4 1 0.02 1.57 0.41
181 INT13283 Egf Regulation of Fgf2 1 0.49 0.11 0.41
182 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 0.16 2.19 0.41
183 INT13284 Fgf2 Regulation of Egf 1 0.49 0.11 0.41
184 INT348790 Binding of MYD88 and Tlr4 1 0.35 1.84 0.4
185 INT303650 Binding of IGF1 and SSTR1 1 0.12 2.17 0.4
186 INT238384 Tlr4 Positive_regulation of Prkca 1 0.06 0.81 0.4
187 INT295478 IRF6 Positive_regulation of Positive_regulation of TLR4 2 0.20 0.78 0.39
188 INT222418 Tlr4 Positive_regulation of Gene_expression of Il1a 1 0.00 0.31 0.39
189 INT152238 Mapk14 Positive_regulation of Localization of Tlr4 1 0.29 0.13 0.39
190 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
191 INT152237 Mapk1 Positive_regulation of Localization of Tlr4 1 0.33 0.13 0.39
192 INT81300 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.02 0.38 0.39
193 INT99304 Igf1 Positive_regulation of Gh1 1 0.44 0.39 0.39
194 INT90807 EGF Positive_regulation of Oprd1 1 0.00 0.39 0.39
195 INT310697 Tlr4 Positive_regulation of Gene_expression of Ptger2 2 0.03 1.34 0.38
196 INT339504 Binding of Irak1 and Tlr4 1 0.08 0.12 0.38
197 INT283840 Binding of Egf and hb 1 0.21 1.34 0.38
198 INT204893 Regulation of Tlr4 Positive_regulation of gr 1 0.11 0.9 0.38
199 INT260746 Binding of TLR4 and Ecm1 1 0.02 0.44 0.38
200 INT147969 Binding of Ly86 and Tlr4 1 0.30 0.37 0.38

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of DNA binding. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of DNA binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
2 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
3 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07
4 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
5 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
6 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
7 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
8 INT56809 Binding of Tlr4 184 0.48 106.02 31.18
9 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47
10 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19
11 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36
12 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
13 INT114362 Localization of Hmgb1 127 0.78 120.28 23.26
14 INT134651 Binding of TLR4 89 0.48 66.96 23.19
15 INT78057 Localization of Tlr4 140 0.77 67.75 21.72
16 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37
17 INT11157 Binding of EGF 88 0.48 53.73 21.25
18 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9
19 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33
20 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47
21 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49
22 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6
23 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
24 INT151120 Negative_regulation of Tlr4 18 0.59 21.09 14.46
25 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68
26 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
27 INT13823 Gene_expression of Egf 97 0.78 39.99 12.99
28 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9
29 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32
30 INT39553 Gene_expression of Hmgb1 50 0.75 51.18 12.21
31 INT118742 Positive_regulation of Tlr4 32 0.69 27.55 11.09
32 INT2036 Localization of EGF 42 0.77 21.5 9.74
33 INT11729 Regulation of IGF1 71 0.61 44.58 9.71
34 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42
35 INT152668 Negative_regulation of EP300 13 0.38 7.78 9.03
36 INT146991 Positive_regulation of Gene_expression of Tlr4 21 0.69 20.76 8.69
37 INT22771 Positive_regulation of Egf 44 0.70 16.45 8.64
38 INT34777 Localization of IGF1 82 0.80 42.68 8.62
39 INT114363 Positive_regulation of Hmgb1 50 0.67 48.92 8.15
40 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
41 INT212758 Binding of Hmgb1 40 0.44 35.6 7.41
42 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41
43 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14
44 INT295467 Negative_regulation of Gene_expression of Tlr4 11 0.58 7.94 6.83
45 INT2037 Negative_regulation of EGF 30 0.59 15.05 6.81
46 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
47 INT13822 Localization of Egf 30 0.81 13.79 6.4
48 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
49 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
50 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
51 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
52 INT97797 Localization of TLR4 18 0.77 13.78 6
53 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95
54 INT8916 Regulation of Igf1 45 0.60 13.06 5.81
55 INT151032 Localization of Igf1 49 0.76 26.32 5.71
56 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69
57 INT190520 Negative_regulation of Hmgb1 24 0.53 20.08 5.6
58 INT168279 Regulation of Tlr4 17 0.54 8.97 5.5
59 INT103899 Gene_expression of ERCC2 14 0.65 7.85 5.49
60 INT145767 Negative_regulation of TLR4 18 0.43 11.03 5.25
61 INT37227 Regulation of EGF 19 0.45 11.16 5.17
62 INT157622 Positive_regulation of Localization of Tlr4 34 0.48 22.63 5.09
63 INT21901 Negative_regulation of Egf 25 0.58 10.46 4.99
64 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
65 INT203443 Gene_expression of Isl1 27 0.67 11.12 4.65
66 INT184269 Gene_expression of HMGB1 51 0.77 42.96 4.55
67 INT29326 Gene_expression of Calm1 17 0.67 3.71 4.53
68 INT2213 Regulation of EP300 10 0.54 4.72 4.5
69 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45
70 INT49360 Localization of Igf1 22 0.76 6.96 4.26
71 INT138698 Gene_expression of Txn1 15 0.77 11.71 4.24
72 INT65926 Positive_regulation of Gene_expression of Egf 26 0.70 12.91 4.18
73 INT215071 Positive_regulation of Localization of Hmgb1 34 0.63 22.03 4.15
74 INT215085 Positive_regulation of Gene_expression of Hmgb1 17 0.63 16.81 4.13
75 INT23653 Binding of Egf 22 0.36 11.34 4.12
76 INT138701 Positive_regulation of Gene_expression of Txn1 10 0.50 9.16 4.03
77 INT215074 Negative_regulation of Localization of Hmgb1 28 0.57 15.09 4
78 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
79 INT41878 Positive_regulation of EP300 13 0.61 5.24 3.95
80 INT184288 Localization of HMGB1 20 0.61 14.5 3.84
81 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77
82 INT186808 Transcription of TLR4 22 0.69 12.77 3.73
83 INT31758 Positive_regulation of Egf 32 0.66 19.42 3.64
84 INT18920 Binding of Egf 24 0.48 9.43 3.57
85 INT143159 Regulation of Gene_expression of TLR4 28 0.62 15.08 3.54
86 INT8096 Positive_regulation of Gene_expression of EGF 21 0.69 13.43 3.47
87 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23
88 INT178711 Protein_catabolism of Tlr4 15 0.84 6.75 3.19
89 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05
90 INT145768 Regulation of TLR4 19 0.45 8.31 2.96
91 INT16130 Binding of IGF1 67 0.48 27.43 2.95
92 INT31757 Negative_regulation of Egf 18 0.41 9.7 2.94
93 INT185315 Transcription of Tlr4 24 0.69 8.65 2.93
94 INT117785 Regulation of Gene_expression of EGF 7 0.44 4.22 2.87
95 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
96 INT28878 Negative_regulation of Localization of Egf 6 0.49 10.34 2.57
97 INT77636 Phosphorylation of Egf 11 0.61 1.69 2.56
98 INT184272 Binding of HMGB1 14 0.37 8.78 2.49
99 INT139735 Positive_regulation of Transcription of Igf1 4 0.53 1.93 2.49
100 INT100086 Negative_regulation of Localization of Tlr4 15 0.37 5.92 2.47
101 INT66544 Binding of Igf1 23 0.46 8.33 2.44
102 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
103 INT171511 Gene_expression of EP300 14 0.53 4.17 2.29
104 INT82226 Negative_regulation of Gene_expression of EGF 11 0.58 6.36 2.13
105 INT108335 Phosphorylation of EGF 17 0.80 7.3 2.09
106 INT26123 Regulation of Ep300 6 0.23 1.22 2.03
107 INT69703 Gene_expression of TXN 20 0.71 3.57 2.01
108 INT171514 Binding of EP300 13 0.32 4.32 2.01
109 INT222609 Binding of Tlr4 8 0.43 4.03 1.98
110 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
111 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95
112 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95
113 INT326816 Negative_regulation of Positive_regulation of Tlr4 2 0.59 3.96 1.95
114 INT132971 Negative_regulation of Localization of IGF1 5 0.42 3.98 1.94
115 INT26124 Negative_regulation of Ep300 5 0.37 1.25 1.94
116 INT295469 Localization of Tlr4 3 0.75 2.22 1.88
117 INT121869 Negative_regulation of Calm1 2 0.57 0 1.83
118 INT172961 Localization of Egf 26 0.71 16.74 1.81
119 INT253755 Regulation of Hmgb1 7 0.55 6.23 1.8
120 INT73721 Negative_regulation of Gene_expression of Egf 5 0.43 2.28 1.8
121 INT103900 Positive_regulation of ERCC2 7 0.58 3.47 1.78
122 INT90800 Negative_regulation of Positive_regulation of EGF 5 0.40 2.78 1.77
123 INT301954 Regulation of Negative_regulation of Tlr4 1 0.45 2.46 1.77
124 INT191862 Phosphorylation of Tlr4 17 0.79 6.89 1.74
125 INT172622 Localization of EP300 8 0.65 2.56 1.72
126 INT19747 Regulation of Egf 14 0.46 4.67 1.68
127 INT66709 Transcription of IGF1 13 0.71 5.65 1.64
128 INT188584 Positive_regulation of Positive_regulation of TLR4 8 0.65 5.98 1.64
129 INT198663 Positive_regulation of HMGB1 14 0.52 11.41 1.58
130 INT184271 Positive_regulation of Gene_expression of HMGB1 7 0.41 6.17 1.53
131 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
132 INT114525 Negative_regulation of Positive_regulation of Egf 4 0.35 2.93 1.5
133 INT49361 Regulation of Positive_regulation of Igf1 2 0.45 2.15 1.49
134 INT100286 Localization of TXN 21 0.73 5.13 1.48
135 INT86382 Negative_regulation of Localization of EGF 5 0.43 1.75 1.44
136 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41
137 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
138 INT90491 Binding of Igf1 25 0.44 9.75 1.36
139 INT179497 Positive_regulation of Binding of Tlr4 12 0.50 6.49 1.27
140 INT27108 Positive_regulation of Localization of Egf 5 0.50 2.91 1.21
141 INT70821 Positive_regulation of Ep300 4 0.25 1.47 1.2
142 INT200838 Positive_regulation of Isl1 6 0.60 0.73 1.19
143 INT142616 Negative_regulation of Positive_regulation of Igf1 5 0.43 1.56 1.16
144 INT219168 Positive_regulation of Localization of HMGB1 5 0.36 4 1.16
145 INT58311 Regulation of Localization of EGF 3 0.54 1.06 1.16
146 INT162124 Positive_regulation of Phosphorylation of Egf 3 0.45 0.77 1.14
147 INT142950 Protein_catabolism of ERCC2 2 0.25 1.45 1.14
148 INT172809 Gene_expression of ISL1 33 0.40 21.63 1.12
149 INT152225 Regulation of Positive_regulation of Tlr4 8 0.53 2.5 1.12
150 INT22770 Regulation of Gene_expression of Egf 5 0.44 2.56 1.12
151 INT28949 Negative_regulation of Positive_regulation of IGF1 11 0.42 5.03 1.11
152 INT37207 Positive_regulation of Positive_regulation of Egf 4 0.50 0.76 1.07
153 INT13817 Protein_catabolism of EGF 3 1.00 1.44 1.06
154 INT72129 Positive_regulation of Positive_regulation of IGF1 11 0.50 4.61 1.05
155 INT105860 Positive_regulation of Positive_regulation of EGF 6 0.64 2.37 1.05
156 INT215077 Negative_regulation of Positive_regulation of Hmgb1 3 0.42 5.09 1.05
157 INT205912 Negative_regulation of Gene_expression of Jak2 8 0.42 5.1 1.04
158 INT169407 Phosphorylation of IGF1 4 0.63 0.83 1.01
159 INT118738 Transcription of Tlr4 4 0.70 1.39 1
160 INT167650 Binding of Ep300 1 0.09 0.14 1
161 INT184240 Positive_regulation of Localization of Egf 2 0.27 3.58 0.99
162 INT215078 Negative_regulation of Gene_expression of Hmgb1 4 0.41 4.3 0.96
163 INT169336 Binding of Jak2 2 0.42 1.31 0.93
164 INT134040 Regulation of Jak2 3 0.41 1.07 0.92
165 INT69705 Positive_regulation of TXN 8 0.63 2.35 0.89
166 INT295466 Positive_regulation of Regulation of Tlr4 2 0.44 1.33 0.89
167 INT168278 Positive_regulation of Phosphorylation of Tlr4 1 0.48 1.05 0.88
168 INT168277 Phosphorylation of Tlr4 1 0.78 1.05 0.88
169 INT184027 Phosphorylation of Jak2 6 0.82 2.58 0.87
170 INT118290 Regulation of Phosphorylation of EGF 1 0.32 0.72 0.87
171 INT208243 Positive_regulation of Phosphorylation of Tlr4 5 0.31 3.74 0.86
172 INT134037 Positive_regulation of Phosphorylation of Jak2 1 0.46 0.25 0.86
173 INT171372 Positive_regulation of Gene_expression of Egf 16 0.66 9.82 0.84
174 INT173472 Positive_regulation of Isl1 1 0.03 0.2 0.83
175 INT202241 Positive_regulation of Negative_regulation of IGF1 5 0.48 1.56 0.82
176 INT224958 Negative_regulation of Transcription of Igf1 5 0.56 1.37 0.81
177 INT237408 Positive_regulation of Positive_regulation of Jak2 1 0.28 1.56 0.79
178 INT210193 Binding of TXN 31 0.44 6.88 0.78
179 INT31759 Negative_regulation of Gene_expression of Egf 6 0.53 5.33 0.77
180 INT188582 Positive_regulation of Transcription of TLR4 2 0.50 4.07 0.77
181 INT190522 Regulation of Gene_expression of Hmgb1 1 0.39 1.47 0.77
182 INT295465 Regulation of Positive_regulation of Tlr4 2 0.39 1.28 0.75
183 INT151128 Positive_regulation of Negative_regulation of Tlr4 2 0.46 1 0.75
184 INT74097 Gene_expression of Ep300 6 0.52 1.89 0.73
185 INT115293 Regulation of Gene_expression of TXN 2 0.19 0.78 0.73
186 INT254115 Negative_regulation of Phosphorylation of Tlr4 5 0.27 3.91 0.71
187 INT22772 Positive_regulation of Negative_regulation of Egf 1 0.50 1.48 0.71
188 INT70652 Negative_regulation of Binding of EGF 7 0.43 4.23 0.7
189 INT161529 Regulation of Gene_expression of Tlr4 3 0.45 2.7 0.69
190 INT243779 Negative_regulation of Gene_expression of Isl1 2 0.30 2.62 0.68
191 INT228042 Positive_regulation of Txn1 1 0.14 0.65 0.68
192 INT138697 Negative_regulation of Gene_expression of Txn1 1 0.41 0.93 0.68
193 INT110854 Phosphorylation of Egf 8 0.75 5.62 0.67
194 INT186800 Positive_regulation of Binding of TLR4 2 0.47 1.31 0.67
195 INT236785 Regulation of Positive_regulation of TLR4 1 0.32 1.28 0.66
196 INT228279 Regulation of Gene_expression of Egf 7 0.43 6.64 0.65
197 INT264709 Gene_expression of Hes1 24 0.76 7.04 0.63
198 INT124211 Protein_catabolism of IGF1 2 1.00 1.29 0.63
199 INT160948 Negative_regulation of Gene_expression of Calm1 1 0.15 0.99 0.62
200 INT226838 Transcription of Isl1 2 0.28 0.36 0.6
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