GO:0043393

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Name regulation of protein binding
Categary Process
Go Slim No
Go Link GO:0043393
Unique Molecular Interactions 84
Total Molecular Interactions 105
Total Single Events 987
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of protein binding. They are ordered first by their pain relevance and then by number of times they were reported for regulation of protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
2 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
3 INT306258 HDAC4 Negative_regulation of Gene_expression of TNF 1 0.09 0.89 0.78
4 INT161951 Positive_regulation of TGFBR1 Positive_regulation of Gene_expression of Ngf 1 0.27 0.99 0.76
5 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
6 INT161950 TGFBR1 Negative_regulation of Localization of Ngf 1 0.23 1.01 0.72
7 INT302644 ARSA Positive_regulation of Gene_expression of TGFBR1 1 0.04 0.29 0.51
8 INT302647 ARSA Positive_regulation of TGFBR1 1 0.03 0.29 0.51
9 INT75488 Binding of TGFB1 and Tgfbr1 1 0.23 0.78 0.41
10 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
11 INT311918 Insrr Negative_regulation of Tgfbr1 1 0.00 0.87 0.26
12 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26
13 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
14 INT311911 Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
15 INT355103 Binding of Ins2 and Ins1 1 0.12 2 0.21
16 INT257218 Camk1 Negative_regulation of Nos1 1 0.04 0.09 0.19
17 INT245332 ATR Regulation of IL6 1 0.03 0.35 0.17
18 INT191355 HDAC4 Positive_regulation of Gene_expression of Shc1 1 0.02 1.07 0.16
19 INT191354 Negative_regulation of HDAC4 Positive_regulation of Gene_expression of Shc1 1 0.02 1.07 0.16
20 INT347638 Negative_regulation of Binding of Atp9a and Hdac4 1 0.01 0.97 0.14
21 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
22 INT245333 ATR Negative_regulation of Protein_catabolism of DCD 1 0.10 0.93 0.14
23 INT347639 Binding of Atp9a and Hdac4 1 0.01 0.97 0.14
24 INT314859 Binding of Cdkn2b and Tgfbr3 1 0.33 1.16 0.14
25 INT138195 Binding of HDAC4 and Creb1 1 0.03 0.17 0.13
26 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
27 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
28 INT337888 Ins1 Positive_regulation of Gene_expression of Ldlrap1 1 0.06 0 0.08
29 INT311917 Gene_expression of Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.31 0.08
30 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
31 INT337889 Binding of Ins1 and Ldlrap1 1 0.06 0.27 0.08
32 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
33 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
34 INT311915 Tgfbr1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
35 INT245329 ATR Negative_regulation of DCD 1 0.10 0.91 0.05
36 INT245331 ATR Regulation of IL1B 1 0.03 0.91 0.05
37 INT245330 ATR Regulation of TNF 1 0.04 0.9 0.05
38 INT193967 Binding of PSEN1 and Psen1 1 0.41 1.2 0.05
39 INT193970 Binding of PSEN1 and Psen2 1 0.36 2.06 0.05
40 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
41 INT331477 PSEN2 Regulation of Gene_expression of Psen1 1 0.00 0.15 0.03
42 INT284916 IL1RN Negative_regulation of HDAC4 1 0.00 1.66 0.03
43 INT265347 Binding of Ocln and Tgfbr1 1 0.18 0.06 0.03
44 INT265345 Binding of Tgfbr1 and Tjp1 1 0.09 0.06 0.03
45 INT331478 Psen1 Regulation of Gene_expression of PSEN2 1 0.00 0.15 0.03
46 INT265343 Positive_regulation of Binding of Tgfbr1 and Tjp1 1 0.12 0.06 0.03
47 INT265348 Positive_regulation of Binding of Ocln and Tgfbr1 1 0.25 0.06 0.03
48 INT126180 Camk1 Positive_regulation of Camkk1 1 0.16 0 0
49 INT314869 Binding of Gdf11 and Tgfbr3 1 0.29 0.14 0
50 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
51 INT265231 Binding of FKBP1A and TGFBR1 1 0.11 0.35 0
52 INT200647 HDAC4 Positive_regulation of CASP9 1 0.10 0.93 0
53 INT193962 Binding of Psen1 and Ncstn 1 0.13 0.08 0
54 INT334644 Binding of PSEN1 and TTN 1 0.01 0 0
55 INT314871 Binding of Tgfbr3 and Atoh7 1 0.33 0.09 0
56 INT337915 Tgfbr1 Positive_regulation of Negative_regulation of Smad2 1 0.05 0.15 0
57 INT265344 sb Negative_regulation of Tgfbr1 1 0.00 0.06 0
58 INT271996 Binding of Plk1 and Tsc1 1 0.09 0.32 0
59 INT193955 Binding of Psen1 and Psen2 1 0.37 1.64 0
60 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0
61 INT286331 Binding of Psen1 and Ror1 1 0.27 0 0
62 INT193968 Binding of PSEN1 and Ps 1 0.07 0.66 0
63 INT262712 Psen1 Regulation of Gene_expression of Bace1 1 0.22 0.07 0
64 INT217400 Binding of Psen1 and Bace1 1 0.17 1.43 0
65 INT286337 PSENEN Regulation of Psen1 1 0.07 0.37 0
66 INT193958 Binding of Pld1 and Psen1 1 0.17 0 0
67 INT277610 Binding of Runx2 and Hdac4 1 0.32 0.78 0
68 INT271997 Binding of Cdk1 and Plk1 1 0.03 0.3 0
69 INT105017 Binding of Slc25a31 and Atr 1 0.16 0.13 0
70 INT200650 HDAC4 Regulation of Gene_expression of AKT1 1 0.16 0.66 0
71 INT193953 Binding of Bcl2l1 and Psen1 1 0.07 0.66 0
72 INT193956 Binding of Psen1 and Rab6a 1 0.15 0 0
73 INT310192 Tgfbr1 Positive_regulation of Regulation of Acvrl1 1 0.01 0 0
74 INT331479 Binding of PSEN2 and Psen1 1 0.00 0.07 0
75 INT200644 HDAC4 Positive_regulation of CASP8 1 0.07 0.92 0
76 INT234221 Negative_regulation of PSEN1 Negative_regulation of Gene_expression of APP 1 0.33 0.32 0
77 INT249822 Foxm1 Positive_regulation of Transcription of Plk1 1 0.50 0.12 0
78 INT337917 Binding of sb and Tgfbr1 1 0.00 1.06 0
79 INT277611 Binding of Mef2c and Hdac4 1 0.34 1.12 0
80 INT314853 Binding of Cdc7 and Tgfbr3 1 0.24 0.09 0
81 INT334645 Binding of PSEN1 and HM13 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of protein binding. They are ordered first by their pain relevance and then by number of times they were reported in regulation of protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
2 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
3 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
4 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42
5 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
6 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
7 INT75484 Gene_expression of Tgfbr1 21 0.64 13.36 3.15
8 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
9 INT163544 Binding of Psen1 40 0.36 15.28 2.42
10 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
11 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
12 INT277591 Gene_expression of Hdac4 22 0.77 7.77 1.79
13 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
14 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
15 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
16 INT277581 Positive_regulation of Hdac4 4 0.50 1.47 1.25
17 INT310164 Negative_regulation of Gene_expression of Tgfbr1 9 0.40 6.11 1.17
18 INT234473 Gene_expression of HDAC4 8 0.18 6.28 0.99
19 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
20 INT265313 Positive_regulation of Tgfbr1 8 0.66 2.95 0.87
21 INT167833 Positive_regulation of Ins2 4 0.50 6.52 0.82
22 INT237406 Positive_regulation of Binding of Psen1 1 0.29 0 0.8
23 INT286313 Transcription of Psen1 9 0.70 2.26 0.76
24 INT161947 Positive_regulation of TGFBR1 2 0.52 1.6 0.76
25 INT312830 Regulation of Ins2 2 0.39 1.45 0.66
26 INT220662 Gene_expression of Camk1 3 0.66 3.17 0.58
27 INT144922 Gene_expression of TGFBR1 4 0.72 0.19 0.57
28 INT291268 Gene_expression of Atr 1 0.06 1.48 0.57
29 INT217394 Regulation of Binding of PSEN1 1 0.44 1.58 0.53
30 INT114450 Gene_expression of Camk1 4 0.03 1.17 0.52
31 INT333910 Positive_regulation of Gene_expression of HDAC4 2 0.07 1.5 0.49
32 INT179685 Positive_regulation of HDAC4 3 0.24 4.09 0.48
33 INT312821 Binding of Ins2 2 0.37 2.13 0.46
34 INT53667 Gene_expression of Ins2 10 0.65 5.65 0.44
35 INT234249 Regulation of PSEN1 6 0.37 2.21 0.43
36 INT114447 Negative_regulation of Regulation of Camk1 1 0.00 0.72 0.43
37 INT114453 Regulation of Camk1 1 0.01 0.72 0.43
38 INT234257 Regulation of Gene_expression of PSEN1 6 0.44 1.98 0.42
39 INT193856 Localization of Psen1 19 0.73 9.79 0.41
40 INT312829 Positive_regulation of Positive_regulation of Ins2 1 0.50 1.73 0.4
41 INT292484 Negative_regulation of TGFBR1 3 0.19 0.75 0.39
42 INT277579 Binding of Hdac4 1 0.37 3.84 0.38
43 INT277604 Negative_regulation of Hdac4 4 0.51 2.89 0.36
44 INT177773 Localization of PSEN1 4 0.73 0.89 0.36
45 INT277598 Regulation of Gene_expression of Hdac4 1 0.45 0.91 0.36
46 INT243089 Gene_expression of Ldlrap1 2 0.65 0.14 0.35
47 INT254816 Negative_regulation of Tgfbr1 20 0.55 9.24 0.34
48 INT114448 Regulation of Gene_expression of Camk1 1 0.01 0.52 0.3
49 INT245337 Gene_expression of ATR 3 0.27 2.06 0.29
50 INT311881 Regulation of Positive_regulation of Tgfbr1 1 0.22 0.97 0.29
51 INT124568 Regulation of HDAC4 5 0.24 3.03 0.27
52 INT316045 Negative_regulation of Negative_regulation of Psen1 1 0.42 1.58 0.27
53 INT261676 Negative_regulation of Positive_regulation of PSEN1 1 0.36 1.59 0.25
54 INT114452 Regulation of Regulation of Camk1 1 0.00 0.38 0.22
55 INT277584 Negative_regulation of Gene_expression of Hdac4 1 0.43 0.85 0.21
56 INT277594 Positive_regulation of Localization of Hdac4 1 0.50 1.71 0.21
57 INT181508 Regulation of Regulation of Psen1 2 0.33 0.51 0.2
58 INT277593 Localization of Hdac4 1 0.75 2.07 0.2
59 INT277600 Positive_regulation of Gene_expression of Hdac4 1 0.60 0.48 0.2
60 INT311886 Phosphorylation of Tgfbr1 1 0.40 0.7 0.19
61 INT312822 Regulation of Transcription of Ins2 1 0.45 0.71 0.18
62 INT312825 Transcription of Ins2 1 0.69 0.7 0.18
63 INT191155 Binding of HDAC4 5 0.08 2.79 0.17
64 INT286317 Positive_regulation of Transcription of Psen1 1 0.37 0.32 0.17
65 INT277601 Positive_regulation of Positive_regulation of Hdac4 1 0.50 0.18 0.16
66 INT105012 Negative_regulation of Atr 1 0.34 0.35 0.16
67 INT277582 Regulation of Hdac4 1 0.45 0.36 0.14
68 INT114451 Negative_regulation of Camk1 1 0.00 0.35 0.14
69 INT245341 Regulation of Gene_expression of ATR 1 0.18 0.94 0.14
70 INT243075 Regulation of Gene_expression of Ldlrap1 2 0.44 0.15 0.13
71 INT336359 Positive_regulation of Phosphorylation of Psen1 1 0.33 0.4 0.13
72 INT114449 Negative_regulation of Gene_expression of Camk1 1 0.00 0.34 0.13
73 INT302662 Negative_regulation of Negative_regulation of TGFBR1 1 0.14 0 0.13
74 INT336361 Phosphorylation of Psen1 1 0.54 0.34 0.13
75 INT337866 Binding of Ldlrap1 1 0.18 0.56 0.12
76 INT312828 Negative_regulation of Gene_expression of Ins2 1 0.37 0.8 0.12
77 INT234460 Negative_regulation of Gene_expression of HDAC4 2 0.04 1.55 0.11
78 INT245339 Regulation of ATR 1 0.18 0.92 0.11
79 INT234465 Regulation of Negative_regulation of HDAC4 1 0.04 0.74 0.11
80 INT201694 Negative_regulation of Gene_expression of PSEN1 3 0.41 2.31 0.1
81 INT355099 Localization of Ins2 1 0.44 0.83 0.09
82 INT273285 Negative_regulation of Localization of Psen1 1 0.36 0.99 0.09
83 INT312832 Negative_regulation of Ins2 1 0.37 0.64 0.09
84 INT254819 Regulation of Negative_regulation of Tgfbr1 1 0.15 1.2 0.09
85 INT193862 Positive_regulation of Positive_regulation of Psen1 3 0.49 0.9 0.08
86 INT193872 Positive_regulation of Localization of Psen1 3 0.49 1.39 0.08
87 INT261678 Positive_regulation of Positive_regulation of PSEN1 1 0.42 0.62 0.08
88 INT193890 Regulation of Positive_regulation of Psen1 1 0.44 0.66 0.08
89 INT193938 Phosphorylation of PSEN1 5 0.79 1.6 0.07
90 INT311885 Positive_regulation of Gene_expression of Tgfbr1 2 0.44 0.35 0.06
91 INT193859 Negative_regulation of Binding of Psen1 3 0.42 1.85 0.05
92 INT331406 Negative_regulation of Regulation of Psen1 1 0.04 0.09 0.05
93 INT277599 Phosphorylation of Hdac4 1 0.82 3.24 0.05
94 INT193865 Protein_catabolism of Psen1 10 0.97 0.37 0.04
95 INT297867 Positive_regulation of Gene_expression of Ins2 1 0.48 2.86 0.04
96 INT259662 Positive_regulation of Regulation of HDAC4 1 0.03 0.77 0.03
97 INT332926 Localization of HDAC4 1 0.10 0.11 0.03
98 INT237226 Gene_expression of Plk1 3 0.59 0.78 0
99 INT208213 Localization of ATR 2 0.50 0.19 0
100 INT265316 Binding of Tgfbr1 2 0.35 0.59 0
101 INT249774 Positive_regulation of Plk1 2 0.41 0.25 0
102 INT265326 Regulation of Tgfbr1 2 0.43 0.17 0
103 INT200682 Phosphorylation of HDAC4 2 0.44 1.24 0
104 INT286327 Regulation of Binding of Psen1 1 0.33 0.16 0
105 INT234250 Positive_regulation of Negative_regulation of PSEN1 1 0.41 0 0
106 INT315214 Negative_regulation of Regulation of Tgfbr1 1 0.41 0 0
107 INT268388 Positive_regulation of Positive_regulation of TGFBR1 1 0.35 0.61 0
108 INT193886 Regulation of Protein_catabolism of Psen1 1 0.44 0.06 0
109 INT271928 Binding of Plk1 1 0.07 0.29 0
110 INT193934 Positive_regulation of Binding of PSEN1 1 0.49 0.92 0
111 INT277580 Regulation of Localization of Hdac4 1 0.39 0 0
112 INT332370 Regulation of Plk1 1 0.21 0.13 0
113 INT331407 Negative_regulation of Transcription of Psen1 1 0.04 0.08 0
114 INT200668 Regulation of Phosphorylation of HDAC4 1 0.24 0.71 0
115 INT332346 Phosphorylation of Plk1 1 0.62 0 0
116 INT177774 Transcription of PSEN1 1 0.33 0.09 0
117 INT272228 Localization of TGFBR1 1 0.34 0.74 0
118 INT249761 Transcription of Plk1 1 0.60 0.12 0
119 INT277577 Transcription of Hdac4 1 0.69 0 0
120 INT235140 Binding of Atr 1 0.00 1.28 0
121 INT314839 Binding of Tgfbr3 1 0.42 0.09 0
122 INT265319 Positive_regulation of Negative_regulation of Tgfbr1 1 0.47 0.53 0
123 INT249770 Positive_regulation of Gene_expression of Plk1 1 0.44 0.12 0
124 INT144920 Positive_regulation of Gene_expression of TGFBR1 1 0.65 0 0
125 INT239368 Negative_regulation of Binding of HDAC4 1 0.06 1.44 0
126 INT298752 Negative_regulation of Camk1 1 0.37 0.74 0
127 INT338233 Regulation of Gene_expression of HDAC4 1 0.03 0.18 0
128 INT332343 Positive_regulation of Phosphorylation of Plk1 1 0.38 0 0
129 INT193844 Positive_regulation of Protein_catabolism of Psen1 1 0.49 0.05 0
130 INT314836 Gene_expression of Tgfbr3 1 0.59 0.09 0
131 INT310176 Localization of Tgfbr1 1 0.11 0.83 0
132 INT271923 Regulation of Binding of Plk1 1 0.09 0.29 0
133 INT252554 Positive_regulation of ATR 1 0.13 0 0
134 INT353775 Negative_regulation of Ldlrap1 1 0.02 1 0
135 INT277603 Negative_regulation of Phosphorylation of Hdac4 1 0.43 0.39 0
136 INT237227 Negative_regulation of Gene_expression of Plk1 1 0.08 0.54 0
137 INT243095 Positive_regulation of Ldlrap1 1 0.49 0.18 0
138 INT234258 Negative_regulation of Phosphorylation of PSEN1 1 0.35 0.49 0
139 INT310179 Positive_regulation of Positive_regulation of Tgfbr1 1 0.08 0 0
140 INT243072 Transcription of Ldlrap1 1 0.67 0 0
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