GO:0043395

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Name heparan sulfate proteoglycan binding
Categary Function
Go Slim No
Go Link GO:0043395
Unique Molecular Interactions 103
Total Molecular Interactions 138
Total Single Events 1822
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for heparan sulfate proteoglycan binding. They are ordered first by their pain relevance and then by number of times they were reported for heparan sulfate proteoglycan binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT280949 Binding of Fst and Inhbe 3 0.01 2.51 1.15
2 INT167819 IFNA1 Positive_regulation of Fst 1 0.39 0 1.07
3 INT146897 Binding of Fst and OR13H1 1 0.01 0 1.05
4 INT272984 Il6 Positive_regulation of Gene_expression of Itgam 1 0.24 0.78 0.96
5 INT140920 Btnl2 Negative_regulation of Itgam 1 0.02 0.88 0.79
6 INT137102 Fst Regulation of Sec22b 1 0.07 0 0.67
7 INT137101 Fst Regulation of Htr1a 1 0.24 0 0.67
8 INT144320 Binding of Fst and Rbm39 1 0.04 0 0.59
9 INT305744 Fst Positive_regulation of Creb1 1 0.12 0.33 0.57
10 INT126153 GPC3 Regulation of CEBPZ 1 0.18 0.13 0.56
11 INT266376 Binding of Ager and Itgam 1 0.00 2.31 0.54
12 INT126154 GPC3 Positive_regulation of CDNF 1 0.02 0.26 0.43
13 INT126151 GPC3 Positive_regulation of CEBPZ 1 0.31 0.26 0.43
14 INT200469 Binding of COL7A1 and COMP 1 0.04 0.91 0.38
15 INT161009 Binding of Cpe and Itgam 1 0.03 0.53 0.37
16 INT161006 Itgam Regulation of Cpb2 1 0.07 0.52 0.37
17 INT161003 Binding of Itgam and Cpb2 1 0.10 0.52 0.37
18 INT161001 Itgam Regulation of Gfap 1 0.13 0.52 0.37
19 INT161002 Binding of Itgam and St13 1 0.11 0.52 0.37
20 INT161008 Itgam Regulation of St13 1 0.08 0.52 0.37
21 INT118743 Tlr4 Positive_regulation of Itgam 1 0.39 0.41 0.35
22 INT61266 Nfkb1 Regulation of Gene_expression of Itgam 1 0.23 0.65 0.32
23 INT212568 Fst Regulation of Gene_expression of Il2 1 0.30 0.07 0.24
24 INT173405 Binding of FCGR3B and Itgam 1 0.06 0.65 0.23
25 INT224454 TNF Positive_regulation of Gene_expression of Itgam 1 0.27 0.35 0.22
26 INT224445 Il1 Positive_regulation of Gene_expression of Itgam 1 0.21 0.35 0.22
27 INT236362 Binding of Gfap and Itgam 1 0.23 2.31 0.2
28 INT137569 Comp Negative_regulation of Positive_regulation of Prl 1 0.23 0 0.2
29 INT279107 Binding of COMP and MATN3 1 0.41 1.43 0.2
30 INT137568 Comp Negative_regulation of Regulation of Prl 1 0.17 0 0.2
31 INT137570 Comp Negative_regulation of Prl 1 0.17 0 0.2
32 INT180560 Binding of COMP and CYP27A1 1 0.12 0.47 0.18
33 INT314534 Ptger2 Regulation of Gene_expression of Itgam 1 0.02 1 0.17
34 INT281302 Binding of Itgam and Fgg 1 0.00 0.62 0.15
35 INT180566 Binding of COMP and DMD 1 0.02 0.72 0.15
36 INT304169 Il33 Positive_regulation of Gene_expression of Itgam 1 0.02 1.18 0.15
37 INT281315 Binding of Gp1bb and Itgam 1 0.00 0.62 0.15
38 INT344710 Lipc Positive_regulation of Positive_regulation of Hdl1 1 0.04 0.87 0.14
39 INT173404 GPER Regulation of Itgam 1 0.02 0.41 0.13
40 INT298548 Itgam Regulation of Fig4 1 0.08 0.05 0.12
41 INT289793 Binding of Comp and Ecm1 1 0.05 2.5 0.12
42 INT289790 Binding of Col7a1 and Comp 1 0.14 1.2 0.12
43 INT289794 Binding of Comp and Fn1 1 0.07 2.59 0.12
44 INT277984 Negative_regulation of Epo Positive_regulation of Localization of Ptprc 1 0.02 0.77 0.12
45 INT234058 Nes Positive_regulation of Itgam 1 0.50 0.08 0.11
46 INT171791 GPER Negative_regulation of Gene_expression of Itgam 1 0.02 0.46 0.11
47 INT266373 Itgam Positive_regulation of Ager 1 0.01 0.84 0.1
48 INT260099 Binding of COMP and IL4 1 0.00 0.18 0.09
49 INT253300 Itgam Positive_regulation of Gene_expression of Ptprc 1 0.19 0.11 0.09
50 INT222511 Il1a Positive_regulation of Gene_expression of Fst 1 0.01 0.32 0.08
51 INT231507 Binding of Ptprc and Tlr4 2 0.21 1.22 0.06
52 INT222431 Tlr4 Positive_regulation of Gene_expression of Fst 1 0.01 0.29 0.06
53 INT173400 Negative_regulation of Binding of GPER and Itgam 1 0.01 0.19 0.06
54 INT236363 Regulation of Binding of Ptprc and Tlr4 1 0.25 1.23 0.06
55 INT173407 Binding of GPER and Itgam 1 0.01 0.26 0.06
56 INT222463 Inhba Positive_regulation of Gene_expression of Fst 1 0.01 0 0.05
57 INT222520 Mzb1 Positive_regulation of Gene_expression of Fst 1 0.04 0 0.05
58 INT222476 Gnrh1 Negative_regulation of Gene_expression of Fst 1 0.04 0 0.05
59 INT173379 Binding of Itgam and Ns5atp9 1 0.01 0.18 0.04
60 INT254390 Binding of FCGR2A and Itgam 1 0.24 0.63 0.04
61 INT173403 GPER Negative_regulation of Binding of Itgam 1 0.01 0.15 0.04
62 INT340558 Gene_expression of Fst Positive_regulation of Akt1 1 0.09 0.41 0.03
63 INT288199 Binding of Ptprc and Trav6-3 1 0.00 0.05 0.03
64 INT289789 Comp Positive_regulation of Gene_expression of Rer1 1 0.55 0.8 0.03
65 INT312289 Binding of Col9a1 and Comp 1 0.09 1.38 0
66 INT279110 COMP Regulation of Localization of MATN3 1 0.59 0.45 0
67 INT104540 FOXG1 Regulation of Lipc 1 0.02 0 0
68 INT325284 Binding of COMP and MCL1 1 0.01 1.69 0
69 INT239325 Eef1a2 Negative_regulation of Lipc 1 0.11 0.84 0
70 INT314537 Il10 Positive_regulation of Gene_expression of Itgam 1 0.21 1.23 0
71 INT281314 Positive_regulation of Stx2 Positive_regulation of Gene_expression of Itgam 1 0.08 0.21 0
72 INT307306 Gene_expression of COMP Positive_regulation of CALR 1 0.27 0.99 0
73 INT296211 Binding of Ptprc and Tg(CAG-EGFP)D4Nagy 1 0.01 0.13 0
74 INT307305 Gene_expression of COMP Positive_regulation of Positive_regulation of CALR 1 0.27 0.41 0
75 INT173380 Ns5atp9 Positive_regulation of Binding of Itgam 1 0.01 0.43 0
76 INT279106 MATN3 Regulation of COMP 1 0.44 0.67 0
77 INT344229 Itgam Regulation of Transcription of Tlr4 1 0.03 0.06 0
78 INT279108 MATN3 Regulation of Localization of COMP 1 0.44 0.67 0
79 INT314374 Binding of Ptprc and Thy1 1 0.04 0.85 0
80 INT228288 Binding of ENG and Ptprc 1 0.06 0.25 0
81 INT344220 Itgam Regulation of Transcription of Tlr2 1 0.03 0.06 0
82 INT249850 Binding of Ptprc and Cd34 1 0.13 0.48 0
83 INT307307 COMP Positive_regulation of EREG 1 0.01 0.46 0
84 INT228285 Binding of Ptprc and Nt5e 1 0.06 0.25 0
85 INT245865 Binding of Cd34 and Ptprc 1 0.04 0 0
86 INT325285 COMP Positive_regulation of UBR5 1 0.00 2.9 0
87 INT289791 Comp Regulation of Gene_expression of Col7a1 1 0.20 0.21 0
88 INT191933 Itgam Positive_regulation of Cpox 1 0.07 0.36 0
89 INT295572 Binding of Fst and Mstn 1 0.13 0.38 0
90 INT173398 GPER Regulation of Binding of Itgam 1 0.01 0 0
91 INT231510 Binding of Ptprc and Gopc 1 0.07 0.17 0
92 INT173381 Binding of Itgam and Mfi2 1 0.01 0 0
93 INT289795 Binding of COMP and Comp 1 0.02 0.99 0
94 INT307310 Binding of CALR and COMP 1 0.28 0.82 0
95 INT302586 Binding of Lipc and Apoa5 1 0.26 0.63 0
96 INT289788 Binding of Comp and Scn8a 1 0.16 1.37 0
97 INT314372 Binding of Eng and Ptprc 1 0.04 0.84 0
98 INT312291 Binding of Comp and Matn3 1 0.06 1.37 0
99 INT307308 Binding of COMP and EREG 1 0.01 0.41 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for heparan sulfate proteoglycan binding. They are ordered first by their pain relevance and then by number of times they were reported in heparan sulfate proteoglycan binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26
2 INT66025 Gene_expression of Itgam 61 0.78 31.26 26.08
3 INT66023 Positive_regulation of Gene_expression of Itgam 25 0.64 12.65 16.56
4 INT65277 Negative_regulation of Fst 20 0.43 4.61 11.83
5 INT15172 Positive_regulation of Itgam 45 0.67 23.54 10.3
6 INT82829 Gene_expression of COMP 104 0.78 57 9.81
7 INT108098 Positive_regulation of Itgam 19 0.70 8.09 8.86
8 INT70572 Gene_expression of Fst 33 0.78 5.22 8.24
9 INT60931 Negative_regulation of Fst 15 0.57 5.44 7.21
10 INT76120 Gene_expression of Ptprc 102 0.59 30.42 7.02
11 INT86060 Positive_regulation of Fst 13 0.64 3.04 6.33
12 INT82828 Positive_regulation of COMP 45 0.61 35.12 6.2
13 INT13170 Gene_expression of Comp 25 0.74 8.68 5.62
14 INT15173 Positive_regulation of Gene_expression of Itgam 59 0.49 21.89 5.43
15 INT65276 Gene_expression of Fst 12 0.65 4.99 5.05
16 INT61252 Negative_regulation of Gene_expression of Itgam 38 0.54 16.48 5.01
17 INT66024 Negative_regulation of Gene_expression of Itgam 9 0.59 5.5 4.38
18 INT118740 Transcription of Itgam 5 0.70 5.11 4.14
19 INT162258 Negative_regulation of Gene_expression of COMP 35 0.58 19.14 3.55
20 INT118095 Regulation of COMP 7 0.43 9.69 3.33
21 INT119769 Binding of Itgam 27 0.36 6.57 3.29
22 INT61259 Negative_regulation of Itgam 16 0.47 11.11 3.27
23 INT279122 Regulation of Gene_expression of COMP 3 0.39 8.82 3.19
24 INT118735 Positive_regulation of Transcription of Itgam 2 0.49 4.24 3.11
25 INT33237 Regulation of Fst 10 0.39 1.3 3
26 INT200470 Positive_regulation of Gene_expression of COMP 13 0.69 13.73 2.93
27 INT73836 Regulation of Comp 4 0.19 4.2 2.79
28 INT171117 Binding of Itgam 35 0.36 14.87 2.76
29 INT187454 Binding of Ptprc 34 0.38 9.66 2.54
30 INT324955 Phosphorylation of Itgam 1 0.37 1.96 2.4
31 INT71273 Positive_regulation of Comp 8 0.42 3.8 2.32
32 INT8052 Negative_regulation of COMP 46 0.58 13.73 2.22
33 INT184305 Gene_expression of Comp 53 0.77 31.66 2.2
34 INT289775 Negative_regulation of Comp 4 0.41 5.69 2.2
35 INT163580 Positive_regulation of Fst 4 0.19 2.85 2.17
36 INT27437 Negative_regulation of Comp 5 0.24 2.8 2.15
37 INT173395 Regulation of Itgam 3 0.25 1.23 2.13
38 INT138316 Regulation of Fst 5 0.44 1.15 1.99
39 INT118201 Negative_regulation of Itgam 3 0.22 3.41 1.99
40 INT61262 Negative_regulation of Positive_regulation of Itgam 5 0.57 4.25 1.95
41 INT94117 Regulation of Gene_expression of Itgam 13 0.36 5.9 1.87
42 INT210709 Regulation of Itgam 8 0.28 9.21 1.76
43 INT175535 Gene_expression of GPC3 5 0.29 4.17 1.74
44 INT280933 Binding of Fst 4 0.12 3.53 1.63
45 INT206528 Negative_regulation of Gene_expression of Ptprc 8 0.34 3.91 1.61
46 INT22329 Gene_expression of Ptprc 36 0.66 15.84 1.59
47 INT128478 Positive_regulation of Ptprc 26 0.44 8.1 1.45
48 INT152885 Localization of Itgam 16 0.73 7.62 1.43
49 INT118097 Localization of COMP 18 0.70 9.99 1.42
50 INT90771 Positive_regulation of Ptprc 20 0.48 8.43 1.27
51 INT184313 Positive_regulation of Comp 4 0.55 4.23 1.24
52 INT97909 Binding of COMP 13 0.37 5.98 1.22
53 INT206515 Regulation of Gene_expression of Ptprc 6 0.39 3.4 1.22
54 INT333999 Protein_catabolism of Comp 1 0.72 1.77 1.19
55 INT119767 Positive_regulation of Binding of Itgam 4 0.49 1.42 1.09
56 INT147464 Binding of Ptprc 13 0.36 15.18 0.98
57 INT173394 Regulation of Gene_expression of Itgam 2 0.11 1.05 0.91
58 INT280942 Localization of Fst 2 0.22 2.13 0.91
59 INT118098 Protein_catabolism of COMP 5 0.66 2.76 0.9
60 INT289785 Negative_regulation of Gene_expression of Comp 4 0.37 3.14 0.88
61 INT108099 Positive_regulation of Positive_regulation of Itgam 1 0.49 0.23 0.83
62 INT315767 Regulation of GPC3 1 0.16 0.34 0.74
63 INT279130 Negative_regulation of Localization of COMP 5 0.51 3.75 0.69
64 INT103484 Binding of Comp 1 0.19 0.36 0.68
65 INT156967 Localization of Fst 2 0.66 0.1 0.66
66 INT15171 Positive_regulation of Positive_regulation of Itgam 4 0.49 1.13 0.64
67 INT156968 Negative_regulation of Localization of Fst 1 0.37 0.1 0.64
68 INT27435 Negative_regulation of Gene_expression of Comp 1 0.15 0.27 0.63
69 INT27436 Regulation of Gene_expression of Comp 1 0.10 0.28 0.63
70 INT184307 Positive_regulation of Gene_expression of Comp 6 0.50 2.48 0.59
71 INT109505 Regulation of Ptprc 3 0.32 2.45 0.58
72 INT45724 Positive_regulation of Lipc 2 0.08 0.84 0.58
73 INT253299 Positive_regulation of Localization of Itgam 4 0.29 3.04 0.55
74 INT349703 Positive_regulation of Transcription of Fst 1 0.46 0.14 0.53
75 INT349725 Transcription of Fst 1 0.63 0.13 0.53
76 INT143131 Regulation of Ptprc 4 0.27 2.56 0.5
77 INT315768 Positive_regulation of GPC3 1 0.29 0.15 0.44
78 INT187463 Positive_regulation of Gene_expression of Ptprc 9 0.44 2.8 0.42
79 INT184310 Regulation of Comp 2 0.49 1.81 0.41
80 INT173393 Negative_regulation of Binding of Itgam 5 0.24 1.03 0.39
81 INT192858 Phosphorylation of Itgam 4 0.47 1.71 0.38
82 INT317694 Negative_regulation of Localization of Fst 1 0.12 0.79 0.36
83 INT197038 Negative_regulation of Positive_regulation of Comp 1 0.23 1.39 0.35
84 INT13168 Localization of Comp 2 0.34 0.31 0.34
85 INT288541 Negative_regulation of Gene_expression of Fst 2 0.23 1.18 0.34
86 INT101540 Positive_regulation of Positive_regulation of COMP 2 0.39 0.77 0.33
87 INT231497 Negative_regulation of Binding of Ptprc 2 0.34 0.99 0.33
88 INT349714 Binding of Fst 1 0.34 0.19 0.32
89 INT147463 Positive_regulation of Binding of Ptprc 2 0.35 0.95 0.3
90 INT236352 Positive_regulation of Binding of Itgam 4 0.36 2.92 0.29
91 INT229586 Localization of Itgam 2 0.38 0.7 0.27
92 INT80059 Negative_regulation of Ptprc 8 0.41 1.85 0.25
93 INT187465 Localization of Ptprc 8 0.62 3.71 0.25
94 INT152888 Transcription of Itgam 4 0.44 1.29 0.25
95 INT187460 Transcription of Ptprc 2 0.44 0.51 0.25
96 INT112142 Transcription of Comp 1 0.26 0.35 0.25
97 INT355260 Positive_regulation of Phosphorylation of Itgam 1 0.09 1.03 0.18
98 INT221002 Transcription of COMP 2 0.60 1.79 0.16
99 INT280906 Negative_regulation of Ptprc 2 0.15 2.26 0.16
100 INT187456 Regulation of Binding of Ptprc 1 0.29 0.51 0.15
101 INT222654 Regulation of Gene_expression of Fst 1 0.09 0 0.15
102 INT118096 Regulation of Negative_regulation of COMP 1 0.23 0.29 0.14
103 INT175046 Negative_regulation of Gene_expression of Ptprc 2 0.30 0.8 0.13
104 INT184306 Localization of Comp 2 0.69 5.1 0.12
105 INT93878 Positive_regulation of Lipc 4 0.47 3.09 0.11
106 INT231491 Regulation of Positive_regulation of Ptprc 1 0.35 0.18 0.1
107 INT175042 Localization of Ptprc 2 0.53 1.41 0.09
108 INT231493 Positive_regulation of Binding of Ptprc 1 0.39 0.19 0.09
109 INT173389 Regulation of Binding of Itgam 1 0.15 0.22 0.08
110 INT46943 Binding of Lipc 2 0.31 1.92 0.06
111 INT13169 Positive_regulation of Gene_expression of Comp 2 0.48 0.24 0.06
112 INT231501 Negative_regulation of Positive_regulation of Ptprc 1 0.34 0.38 0.06
113 INT175044 Positive_regulation of Gene_expression of Ptprc 1 0.35 3.61 0.06
114 INT211537 Localization of Lipc 1 0.61 0.15 0.05
115 INT211555 Gene_expression of Lipc 1 0.52 0.16 0.05
116 INT222593 Negative_regulation of Gene_expression of Fst 1 0.07 0 0.05
117 INT340535 Positive_regulation of Gene_expression of Fst 1 0.26 0.4 0.03
118 INT340540 Regulation of Gene_expression of Fst 1 0.17 0.42 0.03
119 INT222613 Positive_regulation of Gene_expression of Fst 4 0.42 0.25 0
120 INT135479 Negative_regulation of Positive_regulation of Itgam 2 0.59 0.19 0
121 INT231500 Phosphorylation of Ptprc 2 0.33 0.16 0
122 INT175043 Regulation of Gene_expression of Ptprc 1 0.36 0.27 0
123 INT174763 Gene_expression of Lipc 1 0.56 0.72 0
124 INT231492 Protein_catabolism of Ptprc 1 0.52 0.1 0
125 INT174765 Transcription of Lipc 1 0.57 0.61 0
126 INT174764 Negative_regulation of Lipc 1 0.35 0.5 0
127 INT289779 Regulation of Localization of Comp 1 0.39 1.29 0
128 INT259807 Transcription of Ptprc 1 0.04 0.67 0
129 INT289781 Regulation of Gene_expression of Comp 1 0.39 0.39 0
130 INT307329 Negative_regulation of Positive_regulation of COMP 1 0.38 0.12 0
131 INT289777 Transcription of Comp 1 0.53 0 0
132 INT175045 Positive_regulation of Positive_regulation of Ptprc 1 0.35 1.35 0
133 INT312284 Binding of Comp 1 0.30 3.08 0
134 INT191932 Negative_regulation of Binding of Itgam 1 0.17 0.48 0
135 INT211559 Regulation of Lipc 1 0.20 0.22 0
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