GO:0043406

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Name positive regulation of MAP kinase activity
Categary Process
Go Slim No
Go Link GO:0043406
Unique Molecular Interactions 3300
Total Molecular Interactions 4821
Total Single Events 40510
Pain Genes Associated 86

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of MAP kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of MAP kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT254001 Binding of Cxcr4 and Mif 1 0.52 14.17 7.18
2 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62
3 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
4 INT140935 Binding of Cd40lg and Cd40 1 0.30 6.34 5.61
5 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
6 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01
7 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
8 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
9 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
10 INT13729 GHRH Positive_regulation of Localization of GH1 13 0.62 0.59 3.2
11 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
12 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
13 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
14 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
15 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
16 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
17 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
18 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
19 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
20 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
21 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
22 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
23 INT107578 Kitl Negative_regulation of Grin2b 1 0.12 2.05 2.36
24 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
25 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
26 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
27 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
28 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
29 INT140019 Avp Positive_regulation of Localization of Kitl 1 0.00 1 2.13
30 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
31 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
32 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
33 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
34 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
35 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
36 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
37 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
38 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
39 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
40 INT16891 GHRH Regulation of GH1 5 0.37 1.94 1.82
41 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
42 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
43 INT203149 Binding of Mif and Osm 1 0.02 2.93 1.78
44 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76
45 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 3 0.38 4.29 1.71
46 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
47 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
48 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
49 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
50 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
51 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 0.03 1.11 1.67
52 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 0.47 1.01 1.63
53 INT140023 Avp Positive_regulation of Gene_expression of Kitl 1 0.00 0.76 1.62
54 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
55 INT167202 TNF Regulation of Gene_expression of Ngf 1 0.10 1.47 1.6
56 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
57 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59
58 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
59 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
60 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
61 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
62 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
63 INT167201 Gtf3a Regulation of TNF 1 0.01 1.39 1.52
64 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
65 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
66 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
67 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
68 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
69 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45
70 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42
71 INT151514 Olfr155 Negative_regulation of Gene_expression of VEGFA 1 0.00 1.8 1.42
72 INT189299 Atp6v1e1 Positive_regulation of Htr2a 1 0.01 1.01 1.41
73 INT225019 PDGFB Positive_regulation of Gene_expression of Cxcl1 1 0.27 0.54 1.4
74 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
75 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
76 INT351205 VEGFA Positive_regulation of Binding of MRGPRX1 1 0.08 0.65 1.35
77 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
78 INT264327 IL-17 Positive_regulation of Gene_expression of Tnfsf11 1 0.07 3.19 1.33
79 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
80 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
81 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
82 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
83 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
84 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29
85 INT48117 GH1 Positive_regulation of CGA 1 0.10 0 1.28
86 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
87 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26
88 INT296796 Tbrs1 Positive_regulation of Gene_expression of TNF 1 0.00 1.58 1.26
89 INT271602 Binding of Pdgfa and Pdgfrl 1 0.02 0.86 1.25
90 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
91 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
92 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
93 INT253999 Binding of Cxcl12 and Mif 1 0.41 2.26 1.22
94 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
95 INT260833 Binding of NRP2 and Flt1 1 0.00 3.61 1.22
96 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
97 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 0.32 2.09 1.22
98 INT70035 TNF Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
99 INT70032 TNF Regulation of PRF1 1 0.05 1.42 1.21
100 INT70040 TNF Regulation of Negative_regulation of IL10 1 0.09 1.42 1.21
101 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
102 INT62019 CSF2 Regulation of ELANE 1 0.03 0.47 1.21
103 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2
104 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
105 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
106 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
107 INT75483 Binding of SGCG and TGFB1 1 0.52 2.27 1.19
108 INT142077 TGFB1 Negative_regulation of Binding of IDO1 1 0.15 2.07 1.19
109 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
110 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18
111 INT220751 EGF Regulation of GOPC 1 0.08 0 1.18
112 INT107579 Kitl Negative_regulation of Grin2a 1 0.10 1.02 1.18
113 INT220752 Negative_regulation of EGF Regulation of NAV1 1 0.26 0 1.18
114 INT220753 Negative_regulation of EGF Regulation of GOPC 1 0.08 0 1.18
115 INT220748 EGF Regulation of NAV1 1 0.28 0 1.17
116 INT353338 F2r Positive_regulation of Localization of Mif 1 0.68 1.25 1.16
117 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
118 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
119 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
120 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
121 INT99577 Binding of KITLG and Kit 3 0.34 2.33 1.11
122 INT99691 Pdpk1 Positive_regulation of Positive_regulation of VEGFA 1 0.01 0.72 1.11
123 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1
124 INT107264 Binding of TNF and NCR3 1 0.30 1.42 1.1
125 INT136989 EGF Negative_regulation of Positive_regulation of KCNJ2 1 0.04 1.09 1.1
126 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
127 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1
128 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1
129 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
130 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
131 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
132 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
133 INT19887 GHRH Positive_regulation of Positive_regulation of GH1 2 0.56 0.3 1.08
134 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
135 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
136 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07
137 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
138 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
139 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
140 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
141 INT131853 CD40 Negative_regulation of Gene_expression of CD40LG 1 0.09 1.54 1.05
142 INT312097 ELANE Regulation of ALOX5 1 0.08 1.75 1.05
143 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
144 INT136988 EGF Negative_regulation of KCNJ2 1 0.04 1.09 1.04
145 INT152504 Binding of CR1 and Tnf 1 0.00 0.49 1.04
146 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
147 INT133650 Epo Negative_regulation of TNF 1 0.35 2.7 1.04
148 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
149 INT81545 Tnf Positive_regulation of Gtf3a 2 0.03 1.41 1.02
150 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
151 INT53844 Penk Regulation of Kitl 1 0.00 0.9 1
152 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
153 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
154 INT53845 Positive_regulation of Penk Regulation of Kitl 1 0.00 0.9 1
155 INT35157 GH1 Regulation of GHRH 3 0.17 0.5 0.99
156 INT308804 Pld1 Positive_regulation of TNF 1 0.05 2.42 0.99
157 INT143915 Src Regulation of Rbm39 1 0.03 0.18 0.99
158 INT274895 Positive_regulation of Cbr2 Negative_regulation of Gene_expression of TNF 1 0.06 1.21 0.99
159 INT129216 Negative_regulation of RYBP Positive_regulation of Tnf 1 0.01 1.24 0.98
160 INT62017 ELANE Positive_regulation of Localization of ACOT1 1 0.05 0.35 0.98
161 INT41658 IL31RA Regulation of GH1 1 0.09 1.07 0.98
162 INT140934 Binding of Cd40 and Ean5 1 0.09 1.03 0.98
163 INT182022 TNF Positive_regulation of Gene_expression of Tnfrsf11b 1 0.06 1.56 0.98
164 INT209852 TNF Negative_regulation of Gene_expression of CD36 1 0.43 0.61 0.98
165 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
166 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
167 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
168 INT140068 Binding of GH1 and Ghsr 1 0.00 0.47 0.97
169 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 0.48 1.26 0.96
170 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
171 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
172 INT133652 Epo Negative_regulation of Gene_expression of TNF 1 0.35 2.64 0.96
173 INT171264 TNF Positive_regulation of MMP1 2 0.10 2.05 0.95
174 INT188805 TNF Positive_regulation of Gene_expression of Crp 1 0.15 2.96 0.95
175 INT161231 Positive_regulation of Htr1a Positive_regulation of Gene_expression of VEGFA 1 0.67 0.16 0.95
176 INT127263 Adra2a Regulation of Gene_expression of Jun 1 0.07 1.1 0.95
177 INT129206 RYBP Positive_regulation of Gene_expression of TGFB1 1 0.00 1.04 0.95
178 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
179 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
180 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94
181 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
182 INT137922 VEGFA Positive_regulation of Oprm1 1 0.06 0 0.94
183 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
184 INT129211 RYBP Positive_regulation of Gene_expression of Tnf 1 0.01 1.04 0.94
185 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
186 INT137921 VEGFA Positive_regulation of Ephb2 1 0.03 0 0.93
187 INT155259 RUNX1 Negative_regulation of Tnf 1 0.00 1.48 0.93
188 INT72386 Egf Positive_regulation of Phosphorylation of Shc1 1 0.09 0.18 0.93
189 INT13193 FPR1 Positive_regulation of ELANE 3 0.44 1.22 0.92
190 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
191 INT161455 Mmp7 Positive_regulation of Egfr 1 0.03 0.19 0.92
192 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
193 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91
194 INT169469 Binding of Egfr and Tgfa 1 0.19 1.87 0.91
195 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
196 INT271601 Pdgfa Positive_regulation of Pdgfrl 1 0.03 0.83 0.91
197 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
198 INT256646 Tnf Positive_regulation of Positive_regulation of Nfkb1 1 0.22 1.83 0.9
199 INT48113 GH1 Positive_regulation of Localization of CGA 1 0.07 0 0.9
200 INT220744 EGF Positive_regulation of Gene_expression of KRT20 1 0.01 1.26 0.9

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of MAP kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of MAP kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
3 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
4 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
5 INT6852 Localization of TNF 883 0.81 705.95 270.84
6 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2
7 INT6481 Binding of TNF 624 0.48 510.2 214.82
8 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
9 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
10 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
11 INT9660 Regulation of TNF 363 0.62 312.94 139.99
12 INT252 Localization of GH1 529 0.80 227.4 122.05
13 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
14 INT10166 Localization of Tnf 237 0.81 153.95 88.64
15 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91
16 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65
17 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
18 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
19 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
20 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73
21 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
22 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
23 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18
24 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
25 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
26 INT921 Regulation of GH1 172 0.60 52.88 51.04
27 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
28 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
29 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
30 INT531 Gene_expression of GH1 376 0.75 193.45 46.24
31 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
32 INT1726 Positive_regulation of Kitl 65 0.70 38.81 44.85
33 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53
34 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
35 INT13354 Transcription of TNF 108 0.72 85.81 42.32
36 INT101992 Localization of VEGFA 413 0.81 258.23 36.15
37 INT255 Regulation of Localization of GH1 89 0.62 18.71 35.3
38 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
39 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
40 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
41 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66
42 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92
43 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39
44 INT35406 Localization of Tnf 94 0.81 64.63 31.65
45 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52
46 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1
47 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47
48 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
49 INT116737 Localization of Mif 63 0.81 52.97 28.11
50 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
51 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94
52 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
53 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
54 INT2609 Localization of ELANE 111 0.81 50.22 26.63
55 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
56 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
57 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
58 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
59 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67
60 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
61 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23
62 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2
63 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
64 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15
65 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09
66 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03
67 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79
68 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7
69 INT48692 Binding of VEGFA 345 0.48 210.3 21.31
70 INT11157 Binding of EGF 88 0.48 53.73 21.25
71 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63
72 INT40750 Gene_expression of Mif 61 0.78 34.59 20.28
73 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14
74 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09
75 INT3030 Gene_expression of Adra2a 37 0.68 5.58 19.76
76 INT53574 Regulation of Tnf 45 0.62 40.68 19.71
77 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
78 INT66751 Negative_regulation of Localization of Tnf 48 0.59 26 19.36
79 INT5048 Binding of Edn1 55 0.47 18.86 19.16
80 INT66755 Transcription of Tnf 45 0.72 37.1 19.11
81 INT7000 Positive_regulation of Htr2a 42 0.67 9.48 18.7
82 INT14114 Binding of Adra2a 30 0.48 4.24 18.53
83 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86
84 INT12081 Localization of TGFB1 64 0.81 35.4 17.47
85 INT12875 Regulation of Adra2a 26 0.45 7.51 17.35
86 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03
87 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
88 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75
89 INT109110 Positive_regulation of Pde5a 29 0.63 11.16 16.65
90 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51
91 INT209 Positive_regulation of Pde5a 30 0.21 2.54 16.31
92 INT49986 Transcription of Tnf 25 0.72 18.3 16.22
93 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
94 INT96775 Gene_expression of Pdgfa 42 0.54 29.78 15.46
95 INT116736 Positive_regulation of Mif 40 0.70 31.93 15.37
96 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17
97 INT5674 Gene_expression of Adra2a 34 0.77 6.14 15.13
98 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89
99 INT9191 Localization of EDN1 94 0.81 57.01 14.78
100 INT5324 Binding of Htr2a 23 0.47 7.14 14.66
101 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53
102 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
103 INT10173 Binding of Tnf 45 0.48 35.6 14.32
104 INT20071 Positive_regulation of HTR2A 33 0.67 10.89 14
105 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
106 INT22272 Negative_regulation of HTR2A 28 0.57 7.62 13.87
107 INT6365 Localization of Edn1 56 0.81 18.84 13.83
108 INT133156 Binding of Cd40 77 0.48 45.92 13.77
109 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74
110 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68
111 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
112 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31
113 INT94861 Gene_expression of Pde5a 40 0.69 14.73 13.27
114 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
115 INT13823 Gene_expression of Egf 97 0.78 39.99 12.99
116 INT9678 Positive_regulation of Positive_regulation of GH1 32 0.68 8.14 12.97
117 INT30961 Binding of HTR2A 33 0.47 11.44 12.86
118 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71
119 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
120 INT6322 Gene_expression of Ceacam1 46 0.75 32.13 12.46
121 INT72949 Binding of Mif 31 0.46 23.12 11.65
122 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
123 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07
124 INT27258 Regulation of Htr2a 18 0.60 6.37 11.06
125 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75
126 INT11669 Gene_expression of Htr2a 17 0.75 6.78 10.75
127 INT60434 Negative_regulation of Positive_regulation of Tnf 20 0.46 10.01 10.64
128 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53
129 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34
130 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28
131 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14
132 INT12455 Negative_regulation of Adra2a 30 0.54 5.63 10.14
133 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
134 INT35835 Positive_regulation of Htr2a 17 0.67 10.68 9.81
135 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78
136 INT2036 Localization of EGF 42 0.77 21.5 9.74
137 INT6361 Localization of Edn1 30 0.81 19.09 9.7
138 INT16580 Negative_regulation of Htr2a 18 0.57 3.8 9.63
139 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42
140 INT58841 Gene_expression of HTR2A 33 0.75 9.01 9.07
141 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01
142 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
143 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
144 INT48860 Regulation of Localization of Tnf 25 0.61 20.68 8.78
145 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66
146 INT22771 Positive_regulation of Egf 44 0.70 16.45 8.64
147 INT53573 Negative_regulation of Localization of Tnf 19 0.59 11.57 8.54
148 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
149 INT10237 Binding of EDN1 40 0.48 16 8.48
150 INT70896 Gene_expression of PDGFB 48 0.65 33.55 8.39
151 INT12292 Negative_regulation of Positive_regulation of GH1 22 0.58 5.02 8.28
152 INT59276 Transcription of Htr2a 12 0.69 10.47 8.25
153 INT27785 Regulation of HTR2A 11 0.44 8 8.18
154 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89
155 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8
156 INT32210 Gene_expression of Mif 13 0.75 28.48 7.79
157 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
158 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
159 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58
160 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56
161 INT68299 Binding of Tnf 17 0.39 12.55 7.49
162 INT1664 Gene_expression of Kitl 30 0.65 13.63 7.47
163 INT119729 Binding of Tnfsf11 31 0.35 24.02 7.45
164 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41
165 INT104207 Positive_regulation of Gene_expression of Tnfsf11 43 0.69 25.8 7.35
166 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
167 INT134624 Gene_expression of Flt1 77 0.66 48.86 7.27
168 INT66752 Positive_regulation of Transcription of Tnf 15 0.68 10.86 7.26
169 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
170 INT6576 Localization of Adra2a 11 0.71 1.49 7.18
171 INT93003 Binding of CD40 28 0.47 20.25 7.13
172 INT2605 Regulation of ELANE 39 0.61 18.22 7.11
173 INT83531 Gene_expression of KITLG 54 0.65 26 7.07
174 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93
175 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9
176 INT2037 Negative_regulation of EGF 30 0.59 15.05 6.81
177 INT21138 Binding of ADRA2A 16 0.48 5.57 6.8
178 INT43721 Gene_expression of Vegfa 49 0.77 36.18 6.63
179 INT517 Regulation of Mif 16 0.62 5.43 6.55
180 INT13822 Localization of Egf 30 0.81 13.79 6.4
181 INT64052 Positive_regulation of FGFR1 26 0.52 28.47 6.36
182 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31
183 INT11154 Binding of EGFR 149 0.48 96.23 6.29
184 INT136555 Negative_regulation of Tnfsf11 31 0.55 22.23 6.23
185 INT9118 Gene_expression of Ceacam1 37 0.75 17.19 6.12
186 INT35452 Gene_expression of Htr2a 11 0.65 5.11 6.1
187 INT516 Negative_regulation of Mif 13 0.59 6.69 6.08
188 INT13352 Regulation of Kitl 11 0.45 3.91 6.07
189 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06
190 INT9683 Binding of GH1 57 0.47 21.14 5.99
191 INT111545 Phosphorylation of VEGFA 50 0.76 22.19 5.88
192 INT67060 Negative_regulation of Transcription of TNF 17 0.59 12.94 5.88
193 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
194 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78
195 INT6487 Positive_regulation of Positive_regulation of Tnf 21 0.56 16.06 5.64
196 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61
197 INT48201 Localization of Tgfb1 27 0.59 13.65 5.54
198 INT142607 Positive_regulation of Gene_expression of Cd40 41 0.62 13.85 5.51
199 INT7524 Localization of Kitl 9 0.74 3.45 5.49
200 INT58145 Positive_regulation of Localization of Tnf 20 0.67 13.33 5.44
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