GO:0043407

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Name negative regulation of MAP kinase activity
Categary Process
Go Slim No
Go Link GO:0043407
Unique Molecular Interactions 996
Total Molecular Interactions 1433
Total Single Events 10382
Pain Genes Associated 54

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of MAP kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of MAP kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
2 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
3 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
4 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
5 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
6 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
7 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
8 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
9 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
10 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
11 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
12 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
13 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
14 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
15 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
16 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
17 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
18 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
19 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
20 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
21 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
22 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
23 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
24 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
25 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
26 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1 0.48 1.69 1.5
27 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
28 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
29 INT202910 Uchl1 Positive_regulation of Gene_expression of Tacr1 1 0.05 1.65 1.42
30 INT202912 Uchl1 Positive_regulation of Gene_expression of Ntrk2 1 0.08 1.64 1.42
31 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
32 INT116827 Binding of UCHL1 and TRPV1 1 0.41 0.88 1.39
33 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
34 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
35 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
36 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
37 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28
38 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27
39 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
40 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
41 INT70039 IL1B Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
42 INT70038 IL1B Regulation of PRF1 1 0.05 1.42 1.21
43 INT70031 IL1B Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
44 INT70030 IL1B Regulation of IL10 1 0.07 1.42 1.21
45 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
46 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2
47 INT83428 Binding of ADIPOQ and FRTS 3 0.18 2.02 1.19
48 INT146352 Binding of Rgs14 and Mors1 1 0.23 0.27 1.17
49 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
50 INT94502 Il1b Positive_regulation of Gene_expression of Avp 1 0.28 1.97 1.15
51 INT94509 Il1b Positive_regulation of Gene_expression of AVP 1 0.36 1.96 1.15
52 INT66767 Il1b Positive_regulation of Pla2g10 1 0.05 0.47 1.13
53 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
54 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
55 INT66907 Il1b Positive_regulation of Localization of Oxt 2 0.78 0.18 1.12
56 INT167428 Il1b Positive_regulation of Localization of Gpt 1 0.43 1.31 1.11
57 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
58 INT107562 Penk Positive_regulation of Localization of Il1b 1 0.20 0.09 1.09
59 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
60 INT74939 IL1B Positive_regulation of Gene_expression of HGF 1 0.58 0.72 1.09
61 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
62 INT76396 Il10 Negative_regulation of Il1b 2 0.65 1.89 1.08
63 INT107567 Hps4 Positive_regulation of Localization of Il1b 1 0.01 0.09 1.08
64 INT107564 Hps4 Regulation of Localization of Il1b 1 0.01 0.1 1.07
65 INT107560 Penk Regulation of Localization of Il1b 1 0.18 0.1 1.07
66 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
67 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
68 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
69 INT128297 Il1b Positive_regulation of CRH 1 0.02 0.27 1.03
70 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01
71 INT102690 IL1B Positive_regulation of ITGAL 1 0.05 0.87 0.99
72 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98
73 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98
74 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
75 INT159111 Il1a Regulation of Gene_expression of Il1b 1 0.49 0.38 0.97
76 INT240123 MIR885 Negative_regulation of IL1B 1 0.01 1.57 0.96
77 INT130722 Binding of IL1B and Nfkb1 1 0.28 1.23 0.95
78 INT165941 Bmp7 Positive_regulation of Penk 1 0.28 0.43 0.95
79 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 1 0.29 0.43 0.95
80 INT165940 Bmp7 Positive_regulation of Pomc 1 0.29 0.43 0.95
81 INT130725 Binding of IL1B and Il1rn 1 0.01 1.16 0.93
82 INT81919 Binding of HSF1 and IL1B 1 0.42 0.77 0.93
83 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
84 INT161655 Gsr Regulation of Gene_expression of Il1b 1 0.20 1.84 0.9
85 INT63943 Il1b Positive_regulation of Localization of Calca 2 0.46 0.98 0.88
86 INT136349 Il1b Positive_regulation of Positive_regulation of Oprl1 1 0.22 0.27 0.88
87 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
88 INT297332 Apoe Negative_regulation of Gene_expression of Mpz 1 0.02 1.09 0.87
89 INT224585 IL1B Positive_regulation of IL1RN 1 0.02 1.3 0.87
90 INT305406 Binding of CAV3 and ST8SIA2 1 0.16 0 0.86
91 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84
92 INT149628 Il1b Regulation of Gene_expression of Ptgs2 1 0.30 0.84 0.84
93 INT150733 Negative_regulation of Tlr3 Negative_regulation of Positive_regulation of Il1b 1 0.48 1.34 0.83
94 INT10275 Il1b Positive_regulation of Gene_expression of Penk 1 0.49 0.75 0.83
95 INT149626 Il1b Regulation of Gene_expression of Tnf 1 0.41 0.83 0.83
96 INT84717 Il1b Regulation of Cpox 1 0.00 0.37 0.83
97 INT65011 IL1B Positive_regulation of PTGER2 4 0.08 0.92 0.82
98 INT102201 Tnf Regulation of Il1b 3 0.39 2.57 0.82
99 INT83094 IL1B Positive_regulation of Positive_regulation of BDKRB1 1 0.45 0.2 0.81
100 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78
101 INT208354 Binding of Apoe and Hdl1 12 0.13 8.37 0.77
102 INT161485 Il1b Regulation of Gene_expression of TGFB1 1 0.47 1.21 0.77
103 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
104 INT161481 Slc7a12 Regulation of Gene_expression of Il1b 1 0.14 1.21 0.77
105 INT173112 IL1B Positive_regulation of Gene_expression of VCAM1 2 0.43 1.34 0.76
106 INT161482 Il1b Negative_regulation of TGFB1 1 0.45 1.17 0.76
107 INT135180 IL1B Positive_regulation of Gene_expression of TNFSF11 2 0.76 1.73 0.75
108 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
109 INT144299 Il1b Positive_regulation of Oprm1 1 0.42 0.4 0.74
110 INT161484 Binding of TGFB1 and Il1b 1 0.37 1.16 0.73
111 INT150993 Sfpq Positive_regulation of Gene_expression of Il1b 1 0.04 0.7 0.72
112 INT126304 Binding of Rgs2 and Pag1 1 0.16 0.41 0.72
113 INT74941 IL1B Positive_regulation of Gene_expression of PTGER2 1 0.08 0.48 0.72
114 INT65985 IL1B Positive_regulation of Gene_expression of PTGS2 3 0.23 2.62 0.71
115 INT73822 TAC1 Positive_regulation of Localization of IL1B 1 0.04 0.56 0.71
116 INT73824 TFF2 Positive_regulation of Localization of IL1B 1 0.02 0.56 0.71
117 INT83838 Binding of CEACAM6 and Il1b 1 0.05 0 0.71
118 INT113500 IL1B Positive_regulation of Gene_expression of BHLHE23 1 0.18 0.1 0.71
119 INT95148 CEL Regulation of IL1B 1 0.24 0.88 0.7
120 INT334395 IL1B Positive_regulation of Tnf 1 0.11 2.83 0.69
121 INT250932 IL1B Regulation of Gene_expression of BDNF 1 0.06 0.24 0.69
122 INT346233 PREP Regulation of IL1B 1 0.05 1.44 0.69
123 INT172142 IL10 Positive_regulation of Protein_catabolism of IL1B 2 0.03 1.69 0.68
124 INT172132 IL4 Positive_regulation of Protein_catabolism of IL1B 2 0.02 1.69 0.68
125 INT66537 IL1B Positive_regulation of Gene_expression of Fos 1 0.02 0 0.68
126 INT74728 Binding of Slc6a4 and Ptprj 1 0.01 0.48 0.68
127 INT70998 IL1B Regulation of Gene_expression of Icam1 1 0.44 0.95 0.67
128 INT150994 Sfpq Negative_regulation of Gene_expression of Il1b 1 0.03 0.69 0.66
129 INT88194 ZAK Positive_regulation of Gene_expression of IL1B 1 0.07 0.94 0.66
130 INT152111 IL1B Negative_regulation of Ltp 1 0.03 0.85 0.66
131 INT74729 Binding of Mpz and Ptprj 1 0.06 0.15 0.66
132 INT270763 IL1B Negative_regulation of IKBKB 1 0.04 1.13 0.66
133 INT116441 IL1B Positive_regulation of Gene_expression of CCL2 2 0.04 0.62 0.65
134 INT184193 HRAS Negative_regulation of Gene_expression of IL1B 1 0.00 1.12 0.65
135 INT97508 Negative_regulation of Il1b Positive_regulation of Crh 1 0.31 0.89 0.65
136 INT58229 Il1b Regulation of Gene_expression of Fam166a 1 0.01 0 0.64
137 INT172139 IL4 Negative_regulation of IL1B 1 0.02 0.85 0.63
138 INT60328 Il1b Positive_regulation of Tnf 2 0.29 1.84 0.62
139 INT71526 Regulation of Il1b Positive_regulation of Il6 1 0.17 0.14 0.62
140 INT176475 IL1B Positive_regulation of Gene_expression of ICAM1 1 0.02 0.56 0.62
141 INT61826 Tnf Negative_regulation of Il1b 1 0.39 0.89 0.62
142 INT220155 IL1RN Regulation of IL1B 2 0.50 0.93 0.61
143 INT103214 Binding of Il1b and Pnoc 1 0.40 0.23 0.61
144 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61
145 INT132731 Positive_regulation of Binding of Il1b and Il6 1 0.46 1.2 0.61
146 INT128814 Ephb1 Negative_regulation of Gene_expression of Il1b 1 0.02 0.37 0.61
147 INT297344 Apoe Regulation of Binding of Alms1 1 0.08 1.1 0.61
148 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
149 INT66768 Il1b Positive_regulation of Transcription of Pla2g10 1 0.05 0.22 0.6
150 INT83424 Binding of CD40LG and ADIPOQ 2 0.13 1 0.59
151 INT83426 ADIPOQ Negative_regulation of Binding of CD40LG 2 0.21 1 0.59
152 INT105848 Il1b Positive_regulation of Gene_expression of Cpox 1 0.12 0.41 0.59
153 INT81915 HSF1 Negative_regulation of IL1B 1 0.51 0.65 0.59
154 INT81917 HSF1 Positive_regulation of IL1B 1 0.41 0.65 0.59
155 INT128810 Il1b Positive_regulation of Gene_expression of Nos2 1 0.04 0.31 0.59
156 INT96240 Il13 Negative_regulation of Il1b 1 0.17 0.6 0.59
157 INT96242 Il13 Negative_regulation of Gene_expression of Il1b 1 0.15 0.67 0.59
158 INT261372 Gsk3b Regulation of Gene_expression of Ifi205 1 0.00 0.24 0.58
159 INT128603 Il1b Positive_regulation of Gene_expression of Fos 1 0.50 0.59 0.58
160 INT58342 Calca Negative_regulation of Localization of IL1B 1 0.00 0.6 0.58
161 INT54620 IL1B Positive_regulation of Crh 1 0.01 0.39 0.58
162 INT176471 TNF Positive_regulation of Gene_expression of IL1B 1 0.02 0.61 0.57
163 INT297331 Apoe Negative_regulation of Gene_expression of Il6 1 0.14 0.61 0.57
164 INT108387 IL1B Positive_regulation of Localization of MMP1 1 0.27 0.3 0.57
165 INT143938 Il1rn Negative_regulation of Il1b 1 0.04 0.52 0.57
166 INT60665 Il1b Regulation of Oprd1 1 0.05 0 0.57
167 INT58805 Il1b Negative_regulation of LH 1 0.24 0 0.56
168 INT146112 Binding of Il1b and Tnf 1 0.32 1.19 0.56
169 INT94745 Tlr4 Positive_regulation of Transcription of Il1b 1 0.15 0.48 0.56
170 INT80752 Binding of Il1b and El4 1 0.49 0.08 0.54
171 INT134488 Il1b Regulation of Oxt 1 0.30 0.08 0.54
172 INT80751 Negative_regulation of Binding of Il1b and El4 1 0.60 0.08 0.54
173 INT204087 IL1B Positive_regulation of Gene_expression of LEP 1 0.09 2.6 0.54
174 INT59601 Il1b Regulation of Localization of LH 1 0.18 0 0.54
175 INT66769 Negative_regulation of Il1b Positive_regulation of Pla2g10 1 0.04 0.25 0.53
176 INT254761 Igh-Dex Positive_regulation of Apoe 1 0.00 0.08 0.52
177 INT310531 IL6 Regulation of Regulation of ADIPOQ 1 0.19 0.73 0.52
178 INT120383 PRKCD Positive_regulation of Localization of EPHB2 1 0.29 0.42 0.52
179 INT117203 Binding of IL1B and IL6 2 0.20 1.4 0.51
180 INT105849 Il1b Positive_regulation of Positive_regulation of Ptgs1 1 0.07 0.38 0.51
181 INT120384 PRKCD Positive_regulation of Localization of HSPG2 1 0.29 0.42 0.51
182 INT254356 Binding of IFNG and IL1B 1 0.00 1.87 0.51
183 INT254357 Binding of IFNA1 and IL1B 1 0.00 1.88 0.51
184 INT207394 IL1B Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.95 0.51
185 INT120382 PRKCD Positive_regulation of Localization of DYT10 1 0.29 0.42 0.51
186 INT58804 Il1b Negative_regulation of Negative_regulation of LH 1 0.24 0 0.51
187 INT250933 IL1B Positive_regulation of Gene_expression of BDNF 1 0.10 0.27 0.5
188 INT64720 Regulation of IL1B Positive_regulation of IL6 1 0.36 0.65 0.5
189 INT116862 Apoe Positive_regulation of Il10 1 0.30 0.69 0.5
190 INT116863 Apoe Negative_regulation of Hand1 1 0.37 0.69 0.5
191 INT169400 Negative_regulation of IRF6 Positive_regulation of Gene_expression of Il1b 1 0.50 0.62 0.5
192 INT20546 IL1B Regulation of Gene_expression of SGCG 1 0.65 0.14 0.5
193 INT106074 IL1B Positive_regulation of Gene_expression of A2M 1 0.03 0.75 0.49
194 INT254768 DNMT1 Positive_regulation of Gene_expression of Apoe 1 0.02 0.05 0.49
195 INT225025 IL1B Positive_regulation of Positive_regulation of Cxcl1 1 0.04 0.32 0.49
196 INT138151 Tgfb1 Regulation of IL1B 1 0.01 0.29 0.49
197 INT143939 Il1b Regulation of Gene_expression of Fos 1 0.10 0.44 0.49
198 INT10277 Il1b Positive_regulation of Transcription of Penk 1 0.46 0.26 0.49
199 INT94262 IL1B Positive_regulation of Localization of PTGER2 1 0.22 0.8 0.49
200 INT155621 Tnf Regulation of Transcription of Il1b 1 0.51 0.77 0.49

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of MAP kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of MAP kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
2 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
3 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
4 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35
5 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
6 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
7 INT6849 Localization of IL1B 229 0.81 112.56 69.63
8 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
9 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
10 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48
11 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
12 INT6484 Binding of IL1B 122 0.47 75.84 35.07
13 INT9347 Localization of Il1b 58 0.81 26.13 31.53
14 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29
15 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26
16 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
17 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
18 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24
19 INT51029 Negative_regulation of Il1b 34 0.57 29.34 23.62
20 INT48081 Localization of Il1b 46 0.80 21.59 22.4
21 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34
22 INT36054 Transcription of IL1B 53 0.72 32.64 17.31
23 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58
24 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
25 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46
26 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
27 INT25266 Positive_regulation of Localization of IL1B 38 0.69 15.89 14.35
28 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68
29 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63
30 INT101147 Gene_expression of Uchl1 31 0.76 14.73 13.22
31 INT58226 Negative_regulation of Gene_expression of Il1b 24 0.57 18.09 12.68
32 INT51028 Regulation of Il1b 28 0.60 21.15 12.47
33 INT117502 Positive_regulation of Adipoq 70 0.63 40.43 12.03
34 INT86698 Gene_expression of Cav1 38 0.78 16.37 11.75
35 INT148639 Gene_expression of Uchl1 30 0.59 16.76 11.54
36 INT50196 Transcription of Il1b 25 0.69 19.08 10.43
37 INT48078 Regulation of Gene_expression of Il1b 15 0.62 14.78 9.53
38 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28
39 INT168096 Transcription of Cav3 1 0.72 7.23 8.58
40 INT18736 Gene_expression of Ptpn6 19 0.59 4.44 8.06
41 INT66926 Transcription of Il1b 15 0.69 13.16 7.81
42 INT48077 Positive_regulation of Localization of Il1b 17 0.69 8.8 7.68
43 INT50195 Positive_regulation of Positive_regulation of Il1b 12 0.67 7.41 7.64
44 INT182750 Gene_expression of Hmgcr 61 0.58 17.23 7.4
45 INT9491 Positive_regulation of Ptpn6 11 0.51 2.33 7.32
46 INT11378 Negative_regulation of Positive_regulation of IL1B 23 0.59 10.28 7.26
47 INT125136 Regulation of Adipoq 24 0.56 16.82 7.23
48 INT197493 Localization of Apoe 61 0.79 27.48 7.06
49 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94
50 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84
51 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72
52 INT48076 Negative_regulation of Localization of Il1b 10 0.59 3.46 6.58
53 INT48954 Positive_regulation of Localization of Il1b 13 0.53 8.16 6.44
54 INT67130 Negative_regulation of Localization of Il1b 7 0.57 1.36 6.42
55 INT84716 Negative_regulation of Positive_regulation of Il1b 9 0.57 5.34 6.27
56 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2
57 INT146043 Positive_regulation of Gene_expression of Adipoq 39 0.67 29.93 6.12
58 INT80750 Binding of Il1b 11 0.47 7.97 5.95
59 INT63042 Binding of Apoe 59 0.48 31.23 5.88
60 INT50975 Localization of Ptpn6 8 0.65 2.64 5.7
61 INT55578 Regulation of Gene_expression of Il1b 7 0.62 4.74 5.55
62 INT10705 Binding of Il1b 9 0.36 2.8 5.53
63 INT50197 Positive_regulation of Transcription of Il1b 11 0.50 8.95 5.41
64 INT124370 Positive_regulation of Gene_expression of Gsk3b 47 0.67 24.56 5.4
65 INT171033 Localization of SMPD1 15 0.16 11.92 5.16
66 INT171019 Gene_expression of SMPD1 26 0.27 12.08 5.08
67 INT117499 Negative_regulation of Adipoq 28 0.56 24.15 5.07
68 INT135374 Binding of Gsk3b 46 0.48 24.36 4.75
69 INT55758 Positive_regulation of Apoe 15 0.70 11.71 4.69
70 INT16047 Negative_regulation of Positive_regulation of Il1b 11 0.57 5.27 4.66
71 INT68216 Binding of NF1 40 0.48 51.24 4.59
72 INT26787 Localization of Uchl1 10 0.60 5.9 4.48
73 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27
74 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21
75 INT48080 Positive_regulation of Positive_regulation of Il1b 5 0.50 4.3 4.19
76 INT19190 Regulation of Localization of IL1B 14 0.50 8.71 4.12
77 INT70801 Gene_expression of Hmgcr 12 0.42 3.08 4.1
78 INT141443 Phosphorylation of Cav1 6 0.82 4.39 4.03
79 INT84430 Negative_regulation of Smpd1 22 0.59 10.33 3.95
80 INT83431 Binding of ADIPOQ 35 0.48 33.63 3.83
81 INT116642 Negative_regulation of Gsk3b 13 0.57 7.16 3.83
82 INT146350 Phosphorylation of Rgs14 1 0.80 0.79 3.77
83 INT15033 Gene_expression of Apoe 18 0.78 14.97 3.75
84 INT146946 Gene_expression of Lyn 16 0.76 8.9 3.75
85 INT104624 Negative_regulation of Apoe 26 0.59 19.25 3.71
86 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67
87 INT28021 Positive_regulation of Adipoq 42 0.67 30.79 3.58
88 INT27466 Negative_regulation of Kng1 7 0.10 7.79 3.56
89 INT36142 Negative_regulation of Hmgcr 33 0.46 15.91 3.54
90 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53
91 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52
92 INT141148 Gene_expression of BMP7 24 0.71 14.34 3.44
93 INT6339 Negative_regulation of Ptpn6 6 0.14 0.71 3.44
94 INT100295 Gene_expression of Bmp7 27 0.78 14.34 3.3
95 INT72141 Binding of Apoe 11 0.37 10.91 3.27
96 INT36115 Transcription of Uchl1 7 0.60 3.24 3.25
97 INT97710 Localization of Apoe 1 0.79 7.18 3.2
98 INT64 Regulation of Ptpn6 12 0.14 2.45 3.17
99 INT66922 Positive_regulation of Transcription of Il1b 7 0.49 6.58 3.14
100 INT70596 Regulation of Uchl1 5 0.39 3.87 3.11
101 INT117501 Positive_regulation of Gene_expression of Adipoq 24 0.63 12.99 3.1
102 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07
103 INT15157 Gene_expression of INPP5K 30 0.67 15.49 2.85
104 INT93777 Negative_regulation of Rgs2 3 0.43 2.5 2.81
105 INT6479 Negative_regulation of Binding of IL1B 10 0.43 5.1 2.78
106 INT112147 Positive_regulation of Negative_regulation of Il1b 3 0.49 3.42 2.77
107 INT171013 Regulation of SMPD1 4 0.11 4.84 2.74
108 INT86703 Positive_regulation of Gene_expression of Cav1 7 0.70 3.58 2.73
109 INT321018 Protein_catabolism of Ptpn6 1 0.14 0.52 2.73
110 INT10350 Negative_regulation of Regulation of Il1b 3 0.41 0.58 2.69
111 INT50080 Binding of APOE 38 0.45 29.61 2.67
112 INT204340 Localization of ADIPOQ 20 0.75 25.18 2.64
113 INT11379 Positive_regulation of Negative_regulation of IL1B 9 0.49 7.2 2.64
114 INT67618 Positive_regulation of Inpp5k 3 0.45 0.77 2.64
115 INT26974 Negative_regulation of Adipoq 27 0.52 26.01 2.59
116 INT15144 Protein_catabolism of IL1B 11 0.92 4.67 2.58
117 INT171032 Positive_regulation of SMPD1 9 0.12 8.94 2.52
118 INT97713 Negative_regulation of Apoe 4 0.59 4.57 2.52
119 INT144274 Gene_expression of Cav3 28 0.78 3.21 2.47
120 INT111451 Regulation of ADIPOQ 24 0.56 18.81 2.47
121 INT61434 Regulation of Nf1 3 0.26 1.39 2.4
122 INT64700 Binding of Nf1 14 0.45 15.24 2.29
123 INT208344 Positive_regulation of Localization of Apoe 22 0.48 9.6 2.27
124 INT122561 Negative_regulation of Gene_expression of Adipoq 12 0.56 14.02 2.26
125 INT146945 Positive_regulation of Lyn 6 0.49 2.81 2.25
126 INT135451 Positive_regulation of Positive_regulation of Adipoq 3 0.40 2.06 2.24
127 INT142265 Regulation of Apoe 20 0.60 9.52 2.23
128 INT136614 Positive_regulation of Cav1 5 0.46 2.28 2.23
129 INT36055 Positive_regulation of Transcription of IL1B 9 0.49 6.24 2.21
130 INT168959 Gene_expression of CAV3 5 0.65 0.7 2.2
131 INT137629 Binding of Ptpn6 10 0.30 0.42 2.15
132 INT321023 Positive_regulation of Localization of Ptpn6 1 0.07 0.27 2.15
133 INT159645 Negative_regulation of Uchl1 8 0.31 6.84 2.14
134 INT145196 Gene_expression of Irak3 5 0.23 4.23 2.13
135 INT8237 Positive_regulation of Kng1 16 0.69 4.41 2.12
136 INT145195 Positive_regulation of Irak3 4 0.15 3.65 2.12
137 INT73906 Regulation of Transcription of IL1B 5 0.56 3.46 2.1
138 INT84060 Regulation of Apoe 4 0.62 3.33 2.05
139 INT138029 Binding of Adipoq 10 0.40 6.81 2.04
140 INT134633 Localization of Adipoq 9 0.60 6.39 2.03
141 INT55035 Negative_regulation of Negative_regulation of Il1b 4 0.43 1.46 2.02
142 INT168275 Phosphorylation of Il1b 1 0.79 2.39 2.01
143 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97
144 INT171323 Phosphorylation of IL1B 5 0.57 4.13 1.94
145 INT116033 Negative_regulation of Transcription of Il1b 4 0.42 2.05 1.94
146 INT84510 Positive_regulation of Nf1 8 0.69 9.52 1.93
147 INT68181 Binding of Nf1 6 0.48 8.14 1.88
148 INT204018 Localization of Gsk3b 27 0.71 13.67 1.87
149 INT101148 Gene_expression of UCHL1 20 0.70 9.61 1.8
150 INT135077 Binding of GSTP1 11 0.48 7.03 1.8
151 INT14246 Regulation of Positive_regulation of IL1B 7 0.44 3.04 1.77
152 INT86914 Positive_regulation of Smpd1 11 0.43 4.73 1.74
153 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
154 INT227273 Localization of Adipoq 22 0.72 18.04 1.72
155 INT116498 Negative_regulation of Negative_regulation of IL1B 7 0.41 3.08 1.7
156 INT141444 Positive_regulation of Phosphorylation of Cav1 1 0.70 1.76 1.69
157 INT168964 Negative_regulation of Gene_expression of CAV3 1 0.47 0 1.68
158 INT126276 Regulation of Rgs14 1 0.39 0.71 1.63
159 INT135955 Positive_regulation of Cav1 17 0.48 7.73 1.61
160 INT96814 Negative_regulation of APOE 13 0.59 10.64 1.61
161 INT73901 Negative_regulation of Transcription of IL1B 3 0.53 0.46 1.57
162 INT214123 Negative_regulation of Gene_expression of Uchl1 3 0.06 4.52 1.52
163 INT141455 Negative_regulation of Inpp5k 2 0.36 1.09 1.51
164 INT188241 Negative_regulation of ADIPOQ 16 0.43 22.16 1.47
165 INT29856 Negative_regulation of Positive_regulation of Ptpn6 3 0.38 1.24 1.47
166 INT217388 Negative_regulation of Gene_expression of Apoe 11 0.59 6.07 1.4
167 INT20233 Negative_regulation of SMPD1 8 0.51 4.19 1.4
168 INT32625 Positive_regulation of Uchl1 2 0.49 1.39 1.4
169 INT165538 Binding of Bmp7 5 0.37 1.87 1.39
170 INT287241 Positive_regulation of BMP7 10 0.43 2.68 1.38
171 INT97716 Transcription of Apoe 3 0.53 2.61 1.36
172 INT113777 Binding of Hmgcr 3 0.09 2.29 1.35
173 INT26786 Positive_regulation of Uchl1 7 0.34 1.37 1.32
174 INT125296 Regulation of Inpp5k 1 0.22 0 1.32
175 INT116903 Negative_regulation of Hmgcr 32 0.43 10.71 1.3
176 INT53252 Gene_expression of Kng1 7 0.67 2.18 1.27
177 INT94744 Regulation of Transcription of Il1b 3 0.44 2.83 1.26
178 INT141862 Binding of Cav1 11 0.36 1.32 1.25
179 INT131645 Negative_regulation of Nf1 10 0.58 8.12 1.24
180 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23
181 INT97715 Regulation of Gene_expression of Apoe 3 0.62 1.98 1.23
182 INT113336 Positive_regulation of Gene_expression of Apoe 3 0.70 1.79 1.23
183 INT146351 Positive_regulation of Phosphorylation of Rgs14 1 0.45 0.27 1.23
184 INT173114 Positive_regulation of Binding of IL1B 6 0.49 2.56 1.22
185 INT168095 Positive_regulation of Transcription of Cav3 1 0.47 0.91 1.2
186 INT143846 Positive_regulation of INPP5K 5 0.40 6.4 1.17
187 INT167283 Negative_regulation of Phosphorylation of Gsk3b 12 0.59 7.94 1.16
188 INT227275 Negative_regulation of Gene_expression of Adipoq 19 0.53 19.51 1.15
189 INT134036 Regulation of Gsk3b 4 0.60 1.42 1.15
190 INT314388 Positive_regulation of Gene_expression of Ptpn6 3 0.11 0.05 1.15
191 INT321016 Regulation of Positive_regulation of Ptpn6 1 0.05 0.05 1.15
192 INT213277 Positive_regulation of Gene_expression of ADIPOQ 14 0.50 17.7 1.14
193 INT236163 Localization of Hmgcr 6 0.64 0.66 1.12
194 INT163914 Positive_regulation of Prkcd 1 0.67 1.43 1.12
195 INT321020 Regulation of Protein_catabolism of Ptpn6 1 0.06 0.05 1.12
196 INT32545 Localization of Gsk3b 9 0.07 2.88 1.11
197 INT208536 Positive_regulation of Positive_regulation of Gsk3b 6 0.30 4.83 1.11
198 INT98975 Positive_regulation of Hmgcr 7 0.16 3.4 1.06
199 INT168957 Positive_regulation of CAV3 1 0.40 0 1.06
200 INT217390 Negative_regulation of Positive_regulation of Apoe 3 0.37 1.95 1.05
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