GO:0043408

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Name regulation of MAPK cascade
Categary Process
Go Slim No
Go Link GO:0043408
Unique Molecular Interactions 394
Total Molecular Interactions 560
Total Single Events 7339
Pain Genes Associated 27

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of MAPK cascade. They are ordered first by their pain relevance and then by number of times they were reported for regulation of MAPK cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33
2 INT131249 Binding of Bdnf and Ntrk2 11 0.41 4 6.25
3 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
4 INT136514 Binding of Grm1 and Grm5 4 0.12 1.8 3.9
5 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
6 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
7 INT106560 Binding of Ntf3 and Ntrk2 3 0.14 2.47 2.84
8 INT67663 Ins1 Positive_regulation of Ntrk2 1 0.00 0.19 2.59
9 INT251147 Binding of Grin2b and Dlg2 1 0.33 2.75 2.43
10 INT107578 Kitl Negative_regulation of Grin2b 1 0.12 2.05 2.36
11 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28
12 INT161190 CRX Regulation of Gene_expression of Ntrk2 1 0.04 3.05 2.06
13 INT161187 NMS Regulation of Gene_expression of Ntrk2 1 0.43 3.05 2.06
14 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
15 INT168608 Binding of Grin2b and Mmp9 1 0.22 0.41 1.57
16 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
17 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
18 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
19 INT246519 Positive_regulation of Grin2b Positive_regulation of Positive_regulation of Ltp 1 0.25 0.08 1.42
20 INT202912 Uchl1 Positive_regulation of Gene_expression of Ntrk2 1 0.08 1.64 1.42
21 INT293200 Positive_regulation of Grin1 Positive_regulation of Phosphorylation of Grin2b 1 0.24 0.4 1.39
22 INT107104 Positive_regulation of Binding of Bdnf and Ntrk2 1 0.42 1.86 1.34
23 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
24 INT154518 Binding of Ephb6 and Grin2b 1 0.21 0.24 1.28
25 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
26 INT287104 Binding of Ntrk2 and T 1 0.20 3.29 1.26
27 INT112105 Negative_regulation of Dlg2 Negative_regulation of Gene_expression of Grin2b 2 0.40 0.89 1.2
28 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
29 INT256295 Binding of Creb1 and Grin2b 1 0.11 1.21 1.19
30 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
31 INT122267 Prkcg Positive_regulation of Grin2b 1 0.26 0.61 1.14
32 INT242624 Binding of Ngf and Ntrk2 5 0.24 0.48 1.11
33 INT122268 Binding of Grin2b and Grm5 1 0.40 0.52 1.1
34 INT256294 Binding of Grin2b and Ephb1 1 0.28 1.11 1.08
35 INT291966 Pag1 Positive_regulation of Gene_expression of Grin2b 1 0.19 1.91 1.06
36 INT256293 Binding of Grin2b and Insrr 1 0.01 1.06 1.05
37 INT291964 Phex Regulation of Gene_expression of Grin2b 1 0.08 1.39 1.04
38 INT346835 Gene_expression of Efnb2 Positive_regulation of Phosphorylation of Grin2b 1 0.27 1.07 1.03
39 INT353690 Binding of Grin2b and Ca2 1 0.14 1.17 1.01
40 INT30135 S100A9 Positive_regulation of REN 1 0.32 0.32 1
41 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1
42 INT344389 Ephb2 Positive_regulation of Phosphorylation of Grin2b 1 0.16 1.46 0.98
43 INT187111 TIMP2 Regulation of MMP9 1 0.23 1.47 0.97
44 INT132610 Bdnf Positive_regulation of Ntrk2 4 0.46 1.09 0.93
45 INT344381 Olfr360 Negative_regulation of Gene_expression of Grin2b 1 0.01 1.17 0.93
46 INT344390 Olfr360 Negative_regulation of Phosphorylation of Grin2b 1 0.01 1.17 0.93
47 INT344388 Efnb1 Positive_regulation of Phosphorylation of Grin2b 1 0.40 1.45 0.92
48 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
49 INT251152 Dlg2 Positive_regulation of Localization of Grin2b 1 0.43 0.6 0.92
50 INT291962 Pag1 Negative_regulation of Gene_expression of Grin2b 1 0.17 1.56 0.92
51 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
52 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
53 INT108438 Grin2b Regulation of Pdyn 1 0.16 0.25 0.9
54 INT298289 Runx1 Negative_regulation of Ntrk2 1 0.60 1.09 0.87
55 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
56 INT311612 Binding of Drd2 and Sert1 1 0.12 0.65 0.86
57 INT36008 Negative_regulation of Binding of Drd2 and Prl 1 0.01 2.11 0.85
58 INT212290 Binding of Grin2a and Grin2b 2 0.20 1.36 0.82
59 INT245564 Runx3 Negative_regulation of Ntrk2 3 0.61 1.61 0.79
60 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77
61 INT334833 Binding of Drd2 and Ncs1 1 0.05 1.11 0.76
62 INT151339 Positive_regulation of Binding of Drd2 and P9Ehs1 1 0.11 0.22 0.76
63 INT151340 Binding of Drd2 and P9Ehs1 1 0.09 0.22 0.75
64 INT327702 Binding of Comt and Drd2 1 0.28 0.27 0.74
65 INT39091 Negative_regulation of Penk Positive_regulation of Localization of Ren 1 0.30 0 0.74
66 INT39095 Negative_regulation of Agt Positive_regulation of Localization of Ren 1 0.38 0 0.73
67 INT296285 Binding of Car1 and Grin2b 1 0.14 0.32 0.72
68 INT186160 Negative_regulation of Grin2b Negative_regulation of Grin1 1 0.37 0.5 0.72
69 INT296282 Grin2b Regulation of Negative_regulation of Kcnip3 1 0.30 0.3 0.72
70 INT296295 Binding of Grin1 and Grin2b 1 0.16 0.31 0.71
71 INT296298 Grin2b Regulation of Negative_regulation of Hmmr 1 0.03 0.29 0.71
72 INT196526 Binding of TIMP1 and TIMP2 1 0.45 1.49 0.71
73 INT351375 Mir470 Negative_regulation of Ntrk2 1 0.01 1.54 0.7
74 INT335596 Positive_regulation of Grin2b Positive_regulation of Positive_regulation of Car2 1 0.12 0.19 0.69
75 INT282139 Grm1 Regulation of Grip2 1 0.00 0.62 0.69
76 INT249485 Trib3 Negative_regulation of Phosphorylation of Grin2b 1 0.02 0.64 0.68
77 INT161186 Bdnf Regulation of Gene_expression of Ntrk2 1 0.44 1.05 0.68
78 INT142244 Positive_regulation of Ntrk2 Positive_regulation of Tcrg-C1 1 0.77 0 0.67
79 INT142243 Ntrk2 Positive_regulation of Tcrg-C1 1 0.77 0 0.67
80 INT161184 NMS Positive_regulation of Gene_expression of Ntrk2 1 0.55 1.3 0.67
81 INT250084 Negative_regulation of Grin2b Negative_regulation of Positive_regulation of Ltp 1 0.18 0.07 0.66
82 INT249489 Src Negative_regulation of Phosphorylation of Grin2b 1 0.20 0.63 0.66
83 INT250078 Negative_regulation of Grin2b Negative_regulation of Ltp 1 0.18 0.07 0.66
84 INT224693 Timp2 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65
85 INT302441 Binding of GRIN1 and Grin2b 1 0.10 1.27 0.63
86 INT186159 Grin2d Negative_regulation of Grin2b 1 0.21 0.82 0.62
87 INT209131 Binding of Bcl2a1a and Drd2 1 0.22 0.45 0.62
88 INT249484 Trib3 Positive_regulation of Phosphorylation of Grin2b 1 0.01 0.57 0.61
89 INT90119 Ntrk2 Regulation of Gene_expression of Nfkb1 1 0.01 0.27 0.6
90 INT79740 Ntf3 Regulation of Positive_regulation of Ntrk2 1 0.28 0 0.6
91 INT342619 Mmp2 Negative_regulation of Timp2 1 0.42 1.48 0.57
92 INT90115 Ntrk2 Regulation of Jun 1 0.01 0.27 0.57
93 INT282142 Grm1 Positive_regulation of Positive_regulation of Trib3 1 0.01 0.27 0.57
94 INT342621 VEGFA Negative_regulation of Timp2 1 0.09 1.53 0.57
95 INT298271 Proc Negative_regulation of Gene_expression of Ntrk2 1 0.01 0.79 0.56
96 INT298278 Runx1 Negative_regulation of Gene_expression of Ntrk2 1 0.44 0.8 0.56
97 INT261481 Positive_regulation of Binding of Bdnf and Ntrk2 1 0.02 0.21 0.56
98 INT45258 SLAMF6 Positive_regulation of Drd2 1 0.00 0 0.55
99 INT215644 Binding of Drd2 and Adora2a 1 0.03 0.23 0.55
100 INT271889 Binding of DRD2 and ANKK1 1 0.23 0.36 0.55
101 INT251141 Binding of Dlg4 and Grin2b 1 0.14 0.32 0.55
102 INT271888 Binding of DRD2 and DNAJC7 1 0.14 0.36 0.55
103 INT251143 Binding of Grin2b and Dlg3 1 0.22 0.32 0.55
104 INT303653 Binding of DRD2 and SST 1 0.18 0.45 0.54
105 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
106 INT249497 Efnb2 Positive_regulation of Phosphorylation of Grin2b 1 0.02 0.51 0.54
107 INT249479 Binding of Ephb1 and Grin2b 1 0.29 0.37 0.54
108 INT25414 Positive_regulation of Drd2 Positive_regulation of Penk 1 0.38 0 0.53
109 INT150795 ZNF398 Positive_regulation of Localization of TIMP2 1 0.06 0.51 0.53
110 INT150791 THBS1 Negative_regulation of TIMP2 1 0.17 0.5 0.52
111 INT165045 Drd2 Regulation of Cpe 1 0.07 0 0.52
112 INT165042 Drd2 Regulation of Tac1 1 0.22 0 0.52
113 INT345308 Binding of ABCA1 and TIMP2 1 0.00 0.21 0.52
114 INT150798 THBS3 Negative_regulation of TIMP2 1 0.18 0.49 0.52
115 INT196521 Binding of MMP2 and TIMP2 1 0.30 0.68 0.52
116 INT193554 Ntrk2 Positive_regulation of Positive_regulation of Ephb1 1 0.01 0.73 0.52
117 INT165043 Drd2 Regulation of Cck 1 0.20 0 0.52
118 INT208121 Binding of Grin2a and Grin2b 3 0.35 0.06 0.51
119 INT20580 Drd2 Regulation of Akr1d1 1 0.02 0.26 0.51
120 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 0.13 0.97 0.51
121 INT187114 TIMP2 Negative_regulation of ABCA1 1 0.02 0.28 0.51
122 INT150799 ZNF398 Positive_regulation of TIMP2 1 0.09 0.49 0.51
123 INT187116 TIMP2 Negative_regulation of MMP9 1 0.36 1.37 0.5
124 INT134533 Binding of Ntrk2 and Psds1 1 0.01 0 0.5
125 INT135751 Pomc Positive_regulation of Positive_regulation of Id1 1 0.19 0 0.5
126 INT135753 Pomc Positive_regulation of Gene_expression of Id1 1 0.17 0 0.5
127 INT135754 Pomc Positive_regulation of Id1 1 0.17 0 0.5
128 INT250080 Grin2b Positive_regulation of Ltp 1 0.22 0.19 0.49
129 INT208119 Grin2b Positive_regulation of Positive_regulation of Ltp 1 0.16 0.21 0.49
130 INT345306 Binding of MMP14 and TIMP2 1 0.04 0.21 0.48
131 INT249486 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Grin2b 1 0.33 0.4 0.46
132 INT39142 ras Positive_regulation of REN 1 0.01 1.34 0.45
133 INT128043 Positive_regulation of Ntrk2 Positive_regulation of Phosphorylation of Trib3 1 0.07 0.34 0.45
134 INT39143 ras Positive_regulation of Gene_expression of REN 1 0.01 1.35 0.45
135 INT154592 Binding of Ntrk2 and Positive_regulation of Gene_expression of Kcna3 1 0.11 0.16 0.44
136 INT16586 Binding of Drd2 and Nts 1 0.12 0 0.43
137 INT89666 Binding of Adora2a and Drd2 1 0.54 0.4 0.42
138 INT36009 Binding of Drd2 and Prl 1 0.01 1.05 0.42
139 INT105733 Grin2b Negative_regulation of Gene_expression of Grin2a 1 0.22 0.09 0.41
140 INT296296 Binding of Grin2b and Kcnip3 1 0.24 0 0.4
141 INT279620 Negative_regulation of Binding of Grin2a and Grin2b 1 0.18 0.99 0.4
142 INT55588 Drd2 Regulation of Transcription of Gad1 1 0.15 0.07 0.4
143 INT55589 Drd2 Regulation of Gad1 1 0.15 0.07 0.4
144 INT324802 Binding of Cd24a and Siglecg 1 0.03 1.34 0.4
145 INT298296 Gene_expression of Runx1 Negative_regulation of Gene_expression of Ntrk2 1 0.44 0.33 0.39
146 INT128018 Binding of Grm1 and Chi3l4 1 0.01 0.08 0.38
147 INT201485 Ntrk2 Positive_regulation of Prkcg 1 0.01 0.73 0.38
148 INT334835 Negative_regulation of Binding of Drd2 and Ncs1 1 0.04 0.56 0.38
149 INT175016 Binding of REN and S100A6 2 0.11 1.13 0.37
150 INT39093 Negative_regulation of Prss12 Positive_regulation of Localization of Ren 1 0.10 0 0.37
151 INT353391 Binding of DRD4 and GRB2 1 0.37 0.62 0.37
152 INT39094 Negative_regulation of Nts Positive_regulation of Localization of Ren 1 0.16 0 0.37
153 INT39096 Prss12 Negative_regulation of Ren 1 0.12 0 0.37
154 INT37247 Binding of Drd1a and Drd2 1 0.20 0 0.37
155 INT327708 Binding of Drd1a and Drd2 1 0.12 0.12 0.37
156 INT39092 Agt Negative_regulation of Ren 1 0.39 0 0.37
157 INT150196 Grm5 Regulation of Grin2b 1 0.45 0 0.36
158 INT249492 Trib3 Regulation of Phosphorylation of Grin2b 1 0.01 0.23 0.35
159 INT127887 SLC6A3 Regulation of Drd2 1 0.34 0.68 0.34
160 INT27848 Calca Positive_regulation of Localization of Ren 1 0.39 0.06 0.34
161 INT236006 HTR1A Regulation of Grin2b 1 0.00 0 0.33
162 INT53127 Binding of Ntrk2 and Ntf4 1 0.12 0 0.33
163 INT334836 Ncs1 Regulation of Drd2 1 0.02 0.48 0.33
164 INT109894 Drd2 Positive_regulation of FOS 1 0.01 0 0.33
165 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
166 INT165580 Binding of Akt1 and Grin2b 1 0.02 0.2 0.32
167 INT206208 MRO Negative_regulation of CD24 1 0.02 1.87 0.32
168 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31
169 INT318323 Binding of GRB2 and HSPA5 1 0.34 0.28 0.31
170 INT99843 Edn3 Negative_regulation of Localization of Ren 1 0.25 0.42 0.31
171 INT40219 Ang Negative_regulation of REN 1 0.00 0 0.3
172 INT187102 Negative_regulation of Binding of MMP9 and TIMP2 1 0.36 0.69 0.3
173 INT187106 Binding of MMP9 and TIMP2 1 0.30 0.69 0.3
174 INT263749 Binding of Grin2b and Neto1 1 0.38 0 0.3
175 INT39033 Hrh1 Positive_regulation of Localization of Ren 1 0.00 0.29 0.3
176 INT175017 Negative_regulation of Binding of REN and S100A6 1 0.13 0.45 0.29
177 INT187110 Binding of TIMP2 and GOPC 1 0.07 0.64 0.29
178 INT187105 TIMP2 Negative_regulation of Positive_regulation of MMP9 1 0.36 0.36 0.29
179 INT250079 Grin2b Regulation of Ltp 1 0.18 0.31 0.29
180 INT175018 Positive_regulation of Binding of REN and S100A6 1 0.15 0.45 0.29
181 INT273130 Negative_regulation of Binding of Drd2 and Hp 1 0.05 0 0.28
182 INT273129 Binding of Drd2 and Hp 1 0.04 0 0.28
183 INT97594 Penk Regulation of Gene_expression of Drd2 1 0.15 0.1 0.28
184 INT187107 Binding of IGHG3 and TIMP2 1 0.01 0.62 0.28
185 INT191497 Binding of REN and NLRP3 1 0.02 0.55 0.27
186 INT131357 Agtr2 Regulation of Ren 1 0.04 0.88 0.27
187 INT249493 Binding of Grin2b and Src 1 0.17 0.15 0.26
188 INT258757 Binding of Drd2 and Rends1 1 0.00 1.26 0.25
189 INT298297 Pou4f1 Positive_regulation of Gene_expression of Ntrk2 1 0.50 0.36 0.24
190 INT287103 Binding of FL and Ntrk2 1 0.28 0.67 0.24
191 INT14642 PENK Positive_regulation of REN 1 0.72 0.19 0.23
192 INT14643 PENK Positive_regulation of Positive_regulation of REN 1 0.48 0.19 0.23
193 INT298290 Pou4f1 Regulation of Gene_expression of Ntrk2 1 0.29 0.48 0.23
194 INT154591 Binding of Ntrk2 and Positive_regulation of Kcna3 1 0.11 0.08 0.22
195 INT187117 Negative_regulation of TIMP2 Negative_regulation of MMP9 1 0.36 0.6 0.22
196 INT273237 Cdk5 Positive_regulation of Protein_catabolism of Grin2b 1 0.45 1.31 0.22
197 INT164136 Binding of DRD2 and Prl 1 0.09 0 0.22
198 INT164135 Binding of Drd2 and Prl 1 0.04 0 0.22
199 INT208123 Hpcal1 Regulation of Grin2b 1 0.10 0 0.21
200 INT308650 Binding of nt and Ntrk2 1 0.01 0.41 0.21

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of MAPK cascade. They are ordered first by their pain relevance and then by number of times they were reported in regulation of MAPK cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT104000 Phosphorylation of Grin2b 73 0.82 48.34 93.48
2 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91
3 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42
4 INT46 Localization of Ren 233 0.81 46.15 62.44
5 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56
6 INT654 Localization of REN 250 0.81 75.12 47.86
7 INT375 Positive_regulation of REN 293 0.70 152.46 47.55
8 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68
9 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52
10 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43
11 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
12 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14
13 INT103998 Positive_regulation of Phosphorylation of Grin2b 33 0.69 19.08 36.08
14 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62
15 INT13501 Binding of Drd2 65 0.48 23.76 35.6
16 INT130479 Phosphorylation of Grin2b 28 0.77 34.82 34.97
17 INT1116 Regulation of Ren 103 0.62 27.66 33.26
18 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
19 INT93451 Positive_regulation of Gene_expression of Grin2b 43 0.70 29.09 31.89
20 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
21 INT50 Negative_regulation of Localization of Ren 87 0.59 14.94 30.22
22 INT660 Negative_regulation of REN 194 0.59 82.06 29.46
23 INT93033 Negative_regulation of Grin2b 48 0.58 20.94 28.54
24 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
25 INT107577 Negative_regulation of Grin2b 32 0.59 12.35 24.88
26 INT12484 Binding of Drd2 45 0.48 15.17 24.72
27 INT2140 Regulation of REN 104 0.62 28.24 24.49
28 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
29 INT102281 Positive_regulation of Gene_expression of Grin2b 27 0.70 10.38 20.84
30 INT49774 Binding of DRD2 48 0.48 17.42 20.73
31 INT47689 Positive_regulation of Ntrk2 44 0.68 16.84 19.59
32 INT48 Positive_regulation of Localization of Ren 69 0.70 12.47 18.03
33 INT66039 Positive_regulation of Ntrk2 53 0.69 15.87 17.23
34 INT48055 Gene_expression of Grm1 27 0.78 14.29 17.01
35 INT93037 Regulation of Grin2b 26 0.57 11.9 16.92
36 INT92514 Regulation of Grin2b 22 0.50 11.07 16.92
37 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7
38 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
39 INT655 Positive_regulation of Localization of REN 86 0.70 32.41 13.56
40 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
41 INT65172 Negative_regulation of Ntrk2 35 0.59 9.89 13.08
42 INT103996 Negative_regulation of Phosphorylation of Grin2b 11 0.58 7.81 12.85
43 INT122117 Negative_regulation of Gene_expression of Grin2b 20 0.59 11.3 12.55
44 INT481 Regulation of Localization of Ren 37 0.62 5.95 11.61
45 INT100919 Positive_regulation of Grm1 21 0.70 7.82 11.55
46 INT661 Gene_expression of REN 100 0.78 48.21 11.36
47 INT130475 Positive_regulation of Phosphorylation of Grin2b 8 0.47 11.52 10.96
48 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
49 INT1180 Gene_expression of Ren 63 0.77 27.33 10.51
50 INT82769 Positive_regulation of Grm1 20 0.00 7.78 9.82
51 INT1372 Regulation of Localization of REN 50 0.62 5.76 9.81
52 INT80006 Regulation of Gene_expression of Grin2b 8 0.57 3.75 9.62
53 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
54 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
55 INT95342 Gene_expression of GRIN2B 21 0.75 4.99 9.32
56 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
57 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
58 INT6499 Localization of Ntrk2 44 0.79 11.78 8.75
59 INT47682 Transcription of Ntrk2 19 0.69 6.32 8.6
60 INT112104 Binding of Grin2b 21 0.44 6.78 8.16
61 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
62 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
63 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
64 INT93664 Gene_expression of TIMP2 33 0.67 36.67 7.14
65 INT47691 Positive_regulation of Gene_expression of Ntrk2 17 0.62 13.64 6.96
66 INT94649 Gene_expression of Grm1 19 0.77 5.11 6.58
67 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
68 INT24460 Localization of Drd2 12 0.73 2.96 6.46
69 INT47681 Regulation of Ntrk2 17 0.62 3.61 6.31
70 INT44163 Gene_expression of Ren1 69 0.78 97.75 6.27
71 INT15775 Positive_regulation of Ren1 50 0.69 22.38 6.19
72 INT86772 Localization of Drd2 14 0.80 1.93 6.17
73 INT100658 Negative_regulation of Positive_regulation of Grin2b 7 0.41 1.39 6.17
74 INT74593 Transcription of Grin2b 10 0.66 1.21 5.98
75 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
76 INT6681 Positive_regulation of Gene_expression of Drd2 10 0.65 1.78 5.78
77 INT130472 Negative_regulation of Phosphorylation of Grin2b 4 0.40 4.4 5.78
78 INT2613 Negative_regulation of Positive_regulation of Ren 16 0.59 8.2 5.62
79 INT106552 Positive_regulation of Gene_expression of Ntrk2 19 0.68 9.72 5.51
80 INT157802 Negative_regulation of Timp2 7 0.54 5.75 5.51
81 INT113153 Regulation of Grm1 6 0.44 4.11 5.41
82 INT127353 Regulation of Phosphorylation of Grin2b 5 0.45 1.6 5.29
83 INT107103 Negative_regulation of Ntrk2 21 0.59 10.38 5.28
84 INT130478 Localization of Grin2b 11 0.75 2.49 5.28
85 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19
86 INT92541 Localization of Grin2b 11 0.75 2.85 5.14
87 INT106555 Binding of Ntrk2 15 0.48 6.31 5.05
88 INT19993 Negative_regulation of Ren1 43 0.58 20.89 5.04
89 INT100920 Positive_regulation of Gene_expression of Grm1 7 0.70 5.88 4.87
90 INT91055 Negative_regulation of Grm1 7 0.45 5.14 4.87
91 INT94433 Negative_regulation of TIMP2 16 0.55 9.38 4.78
92 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78
93 INT79505 Binding of Grin2b 9 0.36 1.43 4.61
94 INT100520 Regulation of Grm1 8 0.44 1.3 4.48
95 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
96 INT65056 Binding of Ntrk2 20 0.36 3.72 4.42
97 INT3097 Binding of Ren 12 0.48 3.15 4.4
98 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36
99 INT55743 Gene_expression of Timp2 25 0.31 8.95 4.3
100 INT122882 Regulation of Ntrk2 13 0.62 9.7 4.3
101 INT170348 Regulation of Gene_expression of Grin2b 8 0.60 2.29 4.25
102 INT112100 Negative_regulation of Gene_expression of Grin2b 6 0.42 3.71 4.24
103 INT47686 Regulation of Gene_expression of Ntrk2 5 0.44 5.24 4.14
104 INT74814 Binding of Grm1 5 0.45 2.69 4.1
105 INT200047 Negative_regulation of Gene_expression of Ntrk2 8 0.56 10.78 3.95
106 INT163500 Transcription of Grin2b 3 0.67 3.63 3.8
107 INT139646 Positive_regulation of Positive_regulation of Grin2b 4 0.42 3.89 3.74
108 INT134527 Phosphorylation of Ntrk2 7 0.69 3.72 3.65
109 INT228465 Positive_regulation of Timp2 4 0.64 6.29 3.54
110 INT111482 Gene_expression of Cd24a 23 0.72 13.74 3.37
111 INT191807 Gene_expression of CD24 75 0.78 53.92 3.34
112 INT95785 Positive_regulation of Positive_regulation of Grm1 6 0.49 3.59 3.3
113 INT4479 Negative_regulation of Positive_regulation of REN 17 0.56 6.1 3.27
114 INT102209 Negative_regulation of Gene_expression of Drd2 5 0.59 0.46 3.17
115 INT179338 Gene_expression of Timp2 7 0.55 5.75 3.13
116 INT1177 Positive_regulation of Positive_regulation of Ren 16 0.70 6.11 3
117 INT142237 Phosphorylation of Ntrk2 8 0.82 2.24 2.82
118 INT280459 Regulation of Gene_expression of Ntrk2 13 0.62 8.48 2.71
119 INT11283 Negative_regulation of Grm1 5 0.57 0.8 2.63
120 INT108468 Negative_regulation of Gene_expression of Drd2 3 0.41 0.67 2.58
121 INT1815 Positive_regulation of Negative_regulation of Ren 6 0.47 1.32 2.54
122 INT67621 Negative_regulation of Gene_expression of Ntrk2 7 0.41 2.71 2.52
123 INT101055 Regulation of GRIN2B 4 0.61 1.39 2.5
124 INT104733 Positive_regulation of Gene_expression of Ren1 24 0.67 43.87 2.47
125 INT1178 Positive_regulation of Gene_expression of Ren 16 0.60 7.71 2.41
126 INT39394 Regulation of Ren1 13 0.45 4.83 2.4
127 INT27835 Regulation of Positive_regulation of Ren 10 0.44 2.27 2.38
128 INT4588 Positive_regulation of Regulation of Ren 4 0.47 1.24 2.26
129 INT47687 Positive_regulation of Transcription of Ntrk2 5 0.45 2.42 2.24
130 INT120109 Negative_regulation of Timp2 8 0.33 3.28 2.23
131 INT107102 Negative_regulation of Positive_regulation of Ntrk2 6 0.54 1.61 2.21
132 INT103881 Positive_regulation of Binding of DRD2 4 0.69 2.01 2.18
133 INT3533 Binding of REN 24 0.37 10.84 2.16
134 INT27989 Positive_regulation of Gene_expression of REN 18 0.55 12.69 2.11
135 INT2844 Positive_regulation of ID1 6 0.70 3.92 2.03
136 INT135744 Positive_regulation of Id1 4 0.49 3.08 2.02
137 INT101912 Regulation of TIMP2 8 0.44 5.55 2
138 INT246518 Regulation of Negative_regulation of Grin2b 1 0.38 0.07 1.99
139 INT25411 Positive_regulation of Positive_regulation of Drd2 2 0.48 0.5 1.98
140 INT98927 Localization of Grm1 4 0.71 0.42 1.97
141 INT52508 Positive_regulation of TIMP2 7 0.43 8.1 1.96
142 INT67237 Binding of Grm1 7 0.00 1.49 1.94
143 INT151942 Regulation of Negative_regulation of Grin2b 2 0.41 0.41 1.92
144 INT17399 Positive_regulation of Positive_regulation of REN 13 0.69 7.05 1.9
145 INT187128 Binding of TIMP2 11 0.41 6.43 1.9
146 INT74594 Regulation of Transcription of Grin2b 1 0.42 0.17 1.8
147 INT130440 Phosphorylation of GRIN2B 2 0.79 2.93 1.79
148 INT1500 Negative_regulation of Gene_expression of Ren 10 0.43 4.44 1.68
149 INT3084 Negative_regulation of Negative_regulation of REN 6 0.42 2.2 1.68
150 INT215928 Binding of Timp2 1 0.23 0.79 1.66
151 INT44164 Localization of Ren1 18 0.49 10.53 1.49
152 INT107379 Localization of GRIN2B 2 0.73 0.86 1.48
153 INT326192 Negative_regulation of Binding of Ntrk2 1 0.10 1 1.47
154 INT4336 Negative_regulation of Gene_expression of REN 13 0.58 7.22 1.43
155 INT150809 Localization of TIMP2 7 0.65 2.6 1.43
156 INT206244 Binding of CD24 7 0.48 5.71 1.43
157 INT142241 Positive_regulation of Positive_regulation of Ntrk2 3 0.66 0.87 1.43
158 INT75062 Regulation of Transcription of Drd2 1 0.51 0 1.41
159 INT296265 Regulation of Phosphorylation of Grin2b 2 0.44 1.06 1.4
160 INT152371 Regulation of Gene_expression of Grm1 2 0.42 0.54 1.4
161 INT26658 Localization of ID1 1 0.32 0.18 1.33
162 INT245544 Localization of Ntrk2 7 0.77 4.52 1.32
163 INT109272 Negative_regulation of Binding of DRD2 2 0.36 0.76 1.26
164 INT191804 Transcription of CD24 10 0.72 12.43 1.25
165 INT15663 Regulation of Transcription of Drd2 2 0.26 0.1 1.25
166 INT47 Negative_regulation of Negative_regulation of Ren 2 0.59 0.34 1.25
167 INT100921 Positive_regulation of Positive_regulation of Grm1 2 0.47 1.01 1.24
168 INT249527 Positive_regulation of Positive_regulation of Grin2b 2 0.37 1.12 1.22
169 INT123839 Positive_regulation of Timp2 6 0.15 4.69 1.21
170 INT77216 Localization of DRD2 3 0.75 0 1.19
171 INT95347 Negative_regulation of GRIN2B 1 0.57 0 1.19
172 INT143091 Positive_regulation of Negative_regulation of Grin2b 2 0.44 0.9 1.09
173 INT291961 Negative_regulation of Regulation of Grin2b 1 0.30 1.65 1.09
174 INT40249 Regulation of Regulation of Ren 4 0.36 0.83 1.05
175 INT202579 Regulation of Gene_expression of DRD2 4 0.41 1.11 0.99
176 INT187026 Positive_regulation of Gene_expression of TIMP2 3 0.47 2.05 0.96
177 INT214113 Transcription of Ntrk2 2 0.72 1.84 0.96
178 INT77054 Regulation of Gene_expression of Timp2 2 0.05 0.7 0.96
179 INT138941 Regulation of Transcription of Ntrk2 2 0.47 0.76 0.95
180 INT101913 Regulation of Gene_expression of TIMP2 2 0.44 1.2 0.93
181 INT2482 Regulation of Positive_regulation of REN 4 0.59 2.62 0.91
182 INT101056 Positive_regulation of GRIN2B 1 0.23 0.32 0.9
183 INT23756 Regulation of Negative_regulation of REN 5 0.44 0.77 0.87
184 INT186168 Negative_regulation of Negative_regulation of Grin2b 2 0.35 0.54 0.85
185 INT228443 Regulation of Positive_regulation of Ntrk2 3 0.22 0.81 0.84
186 INT11086 Regulation of Positive_regulation of Drd2 2 0.45 1.22 0.84
187 INT44300 Negative_regulation of Regulation of Ren 1 0.42 0.1 0.84
188 INT223641 Transcription of Grm1 3 0.69 1.4 0.83
189 INT143092 Negative_regulation of Negative_regulation of Grin2b 1 0.27 0.33 0.83
190 INT99723 Binding of Ren1 7 0.27 3.98 0.82
191 INT93665 Negative_regulation of Gene_expression of TIMP2 4 0.37 2.47 0.82
192 INT55742 Positive_regulation of Gene_expression of Timp2 2 0.08 1.81 0.82
193 INT40053 Positive_regulation of Positive_regulation of Ren1 4 0.54 4.41 0.81
194 INT342616 Regulation of Timp2 1 0.56 1.75 0.81
195 INT340843 Binding of Cd24a 1 0.02 0.24 0.8
196 INT191806 Positive_regulation of Gene_expression of CD24 13 0.70 9.94 0.79
197 INT9206 Negative_regulation of ID1 5 0.59 2.41 0.79
198 INT13692 Negative_regulation of Positive_regulation of Drd2 1 0.01 0 0.79
199 INT103879 Regulation of Binding of DRD2 1 0.23 0.13 0.79
200 INT16434 Regulation of Positive_regulation of Drd2 1 0.30 0 0.78
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