GO:0043409

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Name negative regulation of MAPK cascade
Categary Process
Go Slim No
Go Link GO:0043409
Unique Molecular Interactions 304
Total Molecular Interactions 417
Total Single Events 3486
Pain Genes Associated 24

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of MAPK cascade. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of MAPK cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT227157 Binding of PEBP1 and Gpm6a 1 0.00 1.28 5.52
2 INT143946 Binding of Pebp1 and Mastl 1 0.00 2.04 3.82
3 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
4 INT8734 Pebp1 Positive_regulation of Oprd1 1 0.01 0 1.54
5 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
6 INT42482 Binding of Cpe and Pebp1 1 0.02 0 0.95
7 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
8 INT305406 Binding of CAV3 and ST8SIA2 1 0.16 0 0.86
9 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
10 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82
11 INT195778 Binding of APC and PROCR 7 0.19 3.78 0.73
12 INT281241 Positive_regulation of P2RX7 Negative_regulation of Gene_expression of P2rx3 1 0.03 0.79 0.71
13 INT263236 DAG1 Positive_regulation of Prkcg 2 0.01 0.31 0.7
14 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7
15 INT48032 Binding of Avp and Pebp1 1 0.00 0 0.68
16 INT48031 Binding of Oxt and Pebp1 1 0.01 0 0.68
17 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67
18 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67
19 INT169217 Binding of Pebp1 and Coc 1 0.00 0.22 0.67
20 INT65256 Pebp1 Regulation of Gene_expression of Basp1 1 0.00 0.05 0.64
21 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
22 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56
23 INT282821 TACR1 Regulation of P2RX7 1 0.01 2.06 0.54
24 INT185490 Atp5o Negative_regulation of Gene_expression of P2rx7 1 0.01 0.87 0.53
25 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
26 INT278122 Negative_regulation of P2rx7 Negative_regulation of Binding of P2RX7 1 0.03 0 0.51
27 INT278105 Negative_regulation of TP63 Negative_regulation of Binding of P2RX7 1 0.00 0 0.51
28 INT182150 Binding of APC and DCPS 1 0.02 1.14 0.48
29 INT114297 Apc Negative_regulation of Gene_expression of Fcer2a 1 0.03 0.96 0.48
30 INT321045 Anpep Positive_regulation of Protein_catabolism of Ptpn6 1 0.01 0.22 0.48
31 INT352892 Binding of CAV1 and ITGA2 1 0.20 1.61 0.47
32 INT151485 Negative_regulation of Binding of Ptpn6 and Oprd1 1 0.00 0 0.47
33 INT151484 Binding of Ptpn6 and Oprd1 1 0.00 0 0.47
34 INT92743 Binding of NF2 and LMOD1 1 0.00 0.08 0.46
35 INT69637 Binding of CAV1 and Zfp354a 1 0.00 0 0.46
36 INT146276 Binding of P2RX4 and P2RX7 1 0.38 0.38 0.43
37 INT169859 P2rx7 Regulation of Gene_expression of Grin1 1 0.17 0 0.43
38 INT321047 Anpep Regulation of Negative_regulation of Ptpn6 1 0.01 0.25 0.43
39 INT92744 Binding of ADRB2 and NF2 1 0.00 0.1 0.41
40 INT223829 Binding of GSTM1 and GSTP1 2 0.41 2.78 0.39
41 INT50624 Binding of Pebp1 and Opcml 2 0.13 0 0.38
42 INT84887 APC Negative_regulation of Gene_expression of PPARD 1 0.36 0.55 0.37
43 INT322015 Binding of IL1B and P2RX7 1 0.07 1 0.37
44 INT205704 P2rx7 Regulation of Localization of Il18 1 0.09 0.67 0.35
45 INT191128 Positive_regulation of P2RX7 Positive_regulation of Localization of Il1b 1 0.02 0.71 0.34
46 INT217041 TNF Positive_regulation of Gene_expression of P2RX7 1 0.50 0.81 0.34
47 INT205713 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8 1 0.03 0.77 0.33
48 INT217025 P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
49 INT217024 Regulation of P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
50 INT205703 P2rx7 Regulation of Positive_regulation of Casp1 1 0.11 0.66 0.33
51 INT205711 P2rx7 Regulation of Localization of IL8 1 0.02 0.92 0.33
52 INT195665 APC Negative_regulation of F8 1 0.04 1.53 0.32
53 INT242164 Wnt2 Positive_regulation of Localization of Apc 1 0.13 1.53 0.32
54 INT191616 Binding of Cbln1 and Nf1 1 0.01 0.2 0.32
55 INT191620 Binding of Nf1 and Gopc 1 0.08 0.2 0.32
56 INT145682 Binding of P2rx4 and P2rx7 2 0.25 0.36 0.31
57 INT195664 APC Negative_regulation of F5 1 0.08 1.51 0.31
58 INT191611 Nf1 Regulation of ras 1 0.26 0.18 0.3
59 INT229635 SPINK5 Positive_regulation of NF1 1 0.01 2.17 0.3
60 INT63122 Binding of APC and Man2a2 1 0.01 0.15 0.3
61 INT224131 Binding of CAV1 and Agtr1a 1 0.00 0.08 0.3
62 INT215789 Fig4 Positive_regulation of Localization of P2rx7 1 0.03 0.53 0.29
63 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
64 INT141870 Binding of Slc2a4 and Cav1 1 0.36 0.38 0.28
65 INT350813 Binding of Apc and Crp 1 0.18 1.12 0.27
66 INT205701 P2rx7 Positive_regulation of Il1 1 0.04 0.8 0.25
67 INT130056 PPARG Positive_regulation of CAV1 1 0.02 0.53 0.25
68 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24
69 INT250536 Ghrh Positive_regulation of Negative_regulation of Ptpn6 1 0.09 0 0.24
70 INT235974 Negative_regulation of Binding of APC and Trav6-3 1 0.00 1.15 0.24
71 INT185489 Atp5o Negative_regulation of P2rx7 1 0.01 0.29 0.24
72 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24
73 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24
74 INT189670 CHKB Negative_regulation of Gene_expression of DAG1 1 0.11 0 0.24
75 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23
76 INT216911 Positive_regulation of P2rx7 Positive_regulation of Localization of Plg 1 0.02 0.13 0.23
77 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
78 INT165637 Ptpn6 Negative_regulation of Positive_regulation of Nfkb1 1 0.02 0.57 0.23
79 INT250782 APC Negative_regulation of F2 1 0.00 0.86 0.23
80 INT316111 APC Negative_regulation of SAE1 1 0.04 1.21 0.22
81 INT288582 Binding of Cav1 and Kcnma1 1 0.11 0 0.22
82 INT220528 Ugt1a6b Positive_regulation of Cav1 1 0.01 1.31 0.22
83 INT195663 APC Negative_regulation of Gene_expression of IL6 1 0.16 1.18 0.22
84 INT335464 Binding of DAG1 and PRKCA 1 0.03 0 0.22
85 INT107219 Binding of P2rx7 and Atp5o 1 0.03 0.07 0.21
86 INT216946 P2rx7 Regulation of Il10 1 0.28 0.17 0.21
87 INT223828 Binding of GSTP1 and MAPK8 1 0.06 1.8 0.21
88 INT107223 APEH Negative_regulation of P2rx7 1 0.00 0.13 0.21
89 INT322011 BSG Regulation of P2RX7 1 0.00 0.48 0.21
90 INT165636 Ptpn6 Regulation of Nfkb1 1 0.01 0.36 0.2
91 INT316110 Binding of APC and SAE1 1 0.03 1.16 0.2
92 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2
93 INT205710 CAMP Positive_regulation of P2rx7 1 0.02 0.47 0.19
94 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18
95 INT103197 Nf1 Negative_regulation of ras 1 0.04 1.19 0.17
96 INT220520 Ugt1a6b Positive_regulation of Gene_expression of Cav1 1 0.01 0.81 0.17
97 INT334106 APC Negative_regulation of NFKB1 1 0.25 1.37 0.17
98 INT191615 Binding of Nf1 and Flna 1 0.08 0.53 0.17
99 INT334108 APC Negative_regulation of TNF 1 0.13 1.36 0.17
100 INT191621 Binding of Drd3 and Nf1 1 0.32 0.53 0.17
101 INT172674 Ptpn6 Negative_regulation of Gene_expression of Plat 1 0.02 1.3 0.16
102 INT168941 Irs2 Regulation of Gene_expression of Igf1r 1 0.39 0.91 0.16
103 INT103198 NF1 Negative_regulation of ras 1 0.05 1.19 0.16
104 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
105 INT155644 Binding of CAV1 and HSD11B1 1 0.39 0.77 0.15
106 INT145055 Pebp1 Negative_regulation of Localization of Nr1i3 1 0.14 0.33 0.14
107 INT315030 Binding of Cav1 and Tmie 1 0.03 0.25 0.14
108 INT315032 Binding of Cav1 and Ryr1 1 0.27 0.2 0.14
109 INT289956 Binding of APC and ICAM1 1 0.04 0.5 0.13
110 INT242163 Wnt2 Positive_regulation of Regulation of Apc 1 0.13 0.71 0.13
111 INT136880 Pebp1 Positive_regulation of Localization of Ncoa6 1 0.33 0.06 0.13
112 INT270827 P2rx7 Positive_regulation of Localization of Panx1 1 0.41 0.18 0.13
113 INT184603 APC Negative_regulation of Gene_expression of TNF 1 0.09 0.97 0.13
114 INT136883 Pebp1 Regulation of Localization of Casr 1 0.51 0 0.12
115 INT68802 Sp1 Regulation of Gene_expression of Pebp1 1 0.24 0 0.12
116 INT316190 Apc Negative_regulation of Positive_regulation of Mapk1 1 0.33 0.66 0.12
117 INT182481 Binding of Cav1 and Ighg2b 1 0.10 0 0.12
118 INT216945 Positive_regulation of P2rx7 Positive_regulation of Positive_regulation of Casp1 1 0.14 0.18 0.12
119 INT322037 Binding of P2RX7 and Myh1 1 0.06 0 0.12
120 INT182482 Binding of Cav1 and Cxcl16 1 0.07 0 0.12
121 INT184608 APC Regulation of Gene_expression of Nppa 1 0.06 1.11 0.12
122 INT299754 Binding of APC and CTLA4 2 0.08 0.97 0.11
123 INT311871 Cav1 Regulation of Mch 1 0.01 0.24 0.11
124 INT74504 Binding of P2rx7 and Rp2 1 0.02 0.19 0.11
125 INT352763 Sms Regulation of Gene_expression of DAG1 1 0.08 0.64 0.11
126 INT191612 Nf1 Positive_regulation of ras 1 0.25 2.6 0.11
127 INT243996 Binding of Dag1 and Dmd 1 0.04 0.08 0.11
128 INT220517 Negative_regulation of Ugt1a6b Positive_regulation of Cav1 1 0.01 0.35 0.1
129 INT223827 MAPK8 Positive_regulation of Gene_expression of GSTP1 1 0.12 0.88 0.1
130 INT262255 Binding of APC and F2R 1 0.05 3 0.1
131 INT205708 Binding of Icam1 and P2rx7 1 0.08 1.03 0.09
132 INT302977 Binding of Cav1 and Smpd2 1 0.08 0.71 0.09
133 INT217036 IRF6 Positive_regulation of Gene_expression of P2rx7 1 0.02 0 0.09
134 INT270824 Binding of P2rx7 and Panx1 1 0.34 0.15 0.09
135 INT220511 Cav1 Negative_regulation of Transcription of Ccnd1 1 0.03 0.83 0.09
136 INT304464 Binding of P2rx7 and P2rx6 1 0.05 0 0.09
137 INT191617 Binding of Nf1 and Rtcd1 1 0.01 0.95 0.08
138 INT270203 Binding of CD28 and Apc 1 0.04 0.58 0.08
139 INT243156 Positive_regulation of P2rx7 Positive_regulation of NOS1 1 0.00 0.08 0.08
140 INT309159 Binding of Cav1 and Positive_regulation of Localization of Esr1 1 0.04 0 0.08
141 INT244027 Binding of Dag1 and Helt 1 0.00 0.05 0.08
142 INT270197 Binding of Apc and Cd86 1 0.02 0.58 0.08
143 INT270829 P2rx7 Positive_regulation of Panx1 1 0.66 0.08 0.08
144 INT340420 Hmmr Regulation of P2rx7 1 0.01 1.12 0.08
145 INT270198 Binding of Apc and Cd80 1 0.02 0.58 0.08
146 INT278164 GSTM1 Positive_regulation of Transcription of GSTP1 1 0.57 0.94 0.07
147 INT283126 Dag1 Positive_regulation of Localization of Aqp4 1 0.47 0.2 0.07
148 INT352766 DAG1 Positive_regulation of Prkd1 1 0.15 0.38 0.07
149 INT270835 Positive_regulation of P2rx7 Positive_regulation of Localization of DPEP1 1 0.04 0.08 0.07
150 INT136875 Pebp1 Regulation of Localization of Ncoa6 1 0.37 0 0.06
151 INT136881 Ncoa6 Regulation of Pebp1 1 0.22 0 0.06
152 INT136879 Ncoa6 Regulation of Localization of Pebp1 1 0.37 0 0.06
153 INT223825 GSTP1 Negative_regulation of MAPK8 1 0.11 1.53 0.06
154 INT183853 Gene_expression of CAV1 Negative_regulation of Positive_regulation of MAPK1 1 0.28 0.25 0.05
155 INT176095 Binding of Apc and EC 1 0.04 0.51 0.05
156 INT352762 DAG1 Regulation of Sms 1 0.03 0.37 0.05
157 INT340427 Positive_regulation of P2rx7 Positive_regulation of Regulation of Pkhd1 1 0.01 1 0.05
158 INT120574 Binding of Apc and Egfr 1 0.27 1.02 0.05
159 INT334107 Binding of APC and APCS 1 0.16 1.52 0.04
160 INT270825 P2rx7 Positive_regulation of Slc37a4 1 0.01 0 0.04
161 INT225230 Ad Positive_regulation of Nf2 1 0.04 1.37 0.04
162 INT352764 DAG1 Positive_regulation of Sms 1 0.06 0.11 0.03
163 INT220512 Cav1 Regulation of Positive_regulation of Cdkn1b 1 0.06 0.85 0.03
164 INT191613 Binding of Nf1 and Rasa1 1 0.06 0.88 0.03
165 INT183896 Gene_expression of CAV1 Negative_regulation of Positive_regulation of Racgap1 1 0.01 0.64 0.03
166 INT314397 Binding of Ptpn6 and Slc17a7 1 0.05 0 0
167 INT351167 CAV1 Negative_regulation of Ppp2r1a 1 0.08 1.5 0
168 INT213034 Hdl1 Positive_regulation of Apc 1 0.08 1.21 0
169 INT288584 Cav1 Regulation of Gene_expression of Kcnma1 1 0.14 0 0
170 INT288594 Regulation of Binding of CAV1 and Kcnma1 1 0.01 0 0
171 INT288588 Binding of Cav1 and Neu3 1 0.01 0 0
172 INT314393 Ptpn6 Regulation of 1190002H23Rik 1 0.01 0 0
173 INT183895 CAV1 Regulation of Positive_regulation of Racgap1 1 0.01 0.37 0
174 INT341502 Negative_regulation of Binding of Apc and Pdcd1 1 0.00 0.53 0
175 INT280960 Binding of Cav3 and Fig4 1 0.08 0 0
176 INT351166 Gtf3a Positive_regulation of Gene_expression of CAV1 1 0.01 0.79 0
177 INT191096 Negative_regulation of Binding of Apc and Esr1 1 0.05 1.07 0
178 INT351156 VEGFA Positive_regulation of Gene_expression of CAV1 1 0.07 0.79 0
179 INT301675 Binding of APC and HLA-E 1 0.01 1.48 0
180 INT280961 Binding of Cav1 and Cpox 1 0.04 0 0
181 INT314402 Positive_regulation of Ptpn6 Regulation of 1190002H23Rik 1 0.02 0 0
182 INT217031 Binding of P2rx7 and Positive_regulation of Casp1 1 0.02 0 0
183 INT280969 Binding of Cav3 and Mgst1 1 0.01 0 0
184 INT286112 Binding of Apc and Afap1 1 0.05 0.71 0
185 INT230762 Binding of DAG1 and Tbx15 1 0.00 0.21 0
186 INT288587 Cav1 Regulation of Binding of Kcnma1 1 0.14 0 0
187 INT288597 Binding of CAV1 and Kcnma1 1 0.01 0.17 0
188 INT236528 Binding of Cav1 and Flna 1 0.06 0.09 0
189 INT314403 Ptpn6 Positive_regulation of Gpsm2 1 0.12 0.07 0
190 INT288596 Positive_regulation of Binding of CAV1 and Kcnma1 1 0.01 0.1 0
191 INT288590 Binding of Cav1 and Abhd14a 1 0.00 0 0
192 INT183857 CAV1 Positive_regulation of RHOC 1 0.46 0.21 0
193 INT183861 Binding of CAV1 and CDC42EP5 1 0.03 3.21 0
194 INT288593 Cav1 Positive_regulation of Binding of Kcnma1 1 0.15 0 0
195 INT314398 Ptpn6 Regulation of Gene_expression of Ctbs 1 0.03 0 0
196 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0
197 INT213007 Hdl1 Regulation of Regulation of Apc 1 0.08 1.24 0
198 INT183864 Gene_expression of CAV1 Negative_regulation of Positive_regulation of RHOC 1 0.39 0.95 0
199 INT217032 Binding of P2rx7 and Positive_regulation of Il1 1 0.02 0 0
200 INT301674 Binding of APC and CD80 1 0.01 0.53 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of MAPK cascade. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of MAPK cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
2 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
3 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
4 INT127046 Gene_expression of P2RX7 65 0.78 34.28 14.76
5 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
6 INT86698 Gene_expression of Cav1 38 0.78 16.37 11.75
7 INT137980 Positive_regulation of P2RX7 30 0.67 22.49 10
8 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
9 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
10 INT168096 Transcription of Cav3 1 0.72 7.23 8.58
11 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
12 INT18736 Gene_expression of Ptpn6 19 0.59 4.44 8.06
13 INT9491 Positive_regulation of Ptpn6 11 0.51 2.33 7.32
14 INT85764 Binding of PEBP1 9 0.44 4.52 7.2
15 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11
16 INT33781 Binding of Pebp1 11 0.44 1.76 6.61
17 INT1280 Negative_regulation of Pebp1 7 0.28 2.12 6.45
18 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25
19 INT94608 Regulation of P2rx7 19 0.23 8.06 6.19
20 INT68882 Binding of P2rx7 16 0.23 4.33 6.17
21 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02
22 INT50975 Localization of Ptpn6 8 0.65 2.64 5.7
23 INT9325 Gene_expression of Igf1r 14 0.77 8.74 5.48
24 INT145680 Regulation of P2rx7 22 0.61 11.92 5.42
25 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22
26 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08
27 INT68216 Binding of NF1 40 0.48 51.24 4.59
28 INT185484 Positive_regulation of Gene_expression of P2rx7 8 0.31 7.44 4.28
29 INT141443 Phosphorylation of Cav1 6 0.82 4.39 4.03
30 INT127047 Negative_regulation of P2RX7 10 0.39 7.17 4.01
31 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92
32 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91
33 INT153666 Gene_expression of CAV1 156 0.77 120.99 3.9
34 INT63121 Binding of APC 29 0.41 23.02 3.8
35 INT6339 Negative_regulation of Ptpn6 6 0.14 0.71 3.44
36 INT129441 Regulation of Gene_expression of P2rx7 8 0.24 4.29 3.32
37 INT21572 Gene_expression of Pebp1 9 0.71 2.52 3.3
38 INT64 Regulation of Ptpn6 12 0.14 2.45 3.17
39 INT144828 Binding of P2rx7 19 0.47 7.84 3.16
40 INT191120 Regulation of P2RX7 8 0.41 5.29 2.96
41 INT137978 Localization of P2RX7 6 0.73 5.04 2.84
42 INT86703 Positive_regulation of Gene_expression of Cav1 7 0.70 3.58 2.73
43 INT321018 Protein_catabolism of Ptpn6 1 0.14 0.52 2.73
44 INT107216 Negative_regulation of Gene_expression of P2rx7 10 0.56 3.39 2.61
45 INT144274 Gene_expression of Cav3 28 0.78 3.21 2.47
46 INT61434 Regulation of Nf1 3 0.26 1.39 2.4
47 INT64700 Binding of Nf1 14 0.45 15.24 2.29
48 INT136614 Positive_regulation of Cav1 5 0.46 2.28 2.23
49 INT168959 Gene_expression of CAV3 5 0.65 0.7 2.2
50 INT147417 Positive_regulation of Gene_expression of Igf1r 3 0.46 1.69 2.2
51 INT137972 Binding of P2RX7 12 0.36 8.01 2.18
52 INT227153 Negative_regulation of PEBP1 1 0.12 0.51 2.17
53 INT137629 Binding of Ptpn6 10 0.30 0.42 2.15
54 INT321023 Positive_regulation of Localization of Ptpn6 1 0.07 0.27 2.15
55 INT144829 Localization of P2rx7 12 0.79 2.92 2.12
56 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97
57 INT84510 Positive_regulation of Nf1 8 0.69 9.52 1.93
58 INT9336 Negative_regulation of Gene_expression of Igf1r 4 0.42 3.53 1.92
59 INT68181 Binding of Nf1 6 0.48 8.14 1.88
60 INT13707 Positive_regulation of Pebp1 3 0.41 0.24 1.88
61 INT216936 Negative_regulation of Gene_expression of P2rx7 5 0.42 2.59 1.84
62 INT135077 Binding of GSTP1 11 0.48 7.03 1.8
63 INT4188 Binding of NF2 7 0.46 3.52 1.79
64 INT141385 Positive_regulation of Gene_expression of P2RX7 7 0.62 3.95 1.73
65 INT1347 Localization of Pebp1 2 0.48 0.17 1.69
66 INT141444 Positive_regulation of Phosphorylation of Cav1 1 0.70 1.76 1.69
67 INT3818 Regulation of Apc 13 0.39 12.52 1.68
68 INT168964 Negative_regulation of Gene_expression of CAV3 1 0.47 0 1.68
69 INT135955 Positive_regulation of Cav1 17 0.48 7.73 1.61
70 INT23786 Positive_regulation of Positive_regulation of P2rx7 5 0.44 2.21 1.58
71 INT125735 Transcription of P2rx7 3 0.62 1.34 1.58
72 INT29856 Negative_regulation of Positive_regulation of Ptpn6 3 0.38 1.24 1.47
73 INT215757 Transcription of P2rx7 3 0.21 1.84 1.45
74 INT205691 Regulation of Gene_expression of P2rx7 5 0.44 3.25 1.42
75 INT220177 Binding of Apc 21 0.37 15.34 1.37
76 INT173328 Positive_regulation of DAG1 6 0.31 1.74 1.36
77 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3
78 INT202817 Gene_expression of Dag1 16 0.75 7.82 1.3
79 INT205690 Positive_regulation of Positive_regulation of P2rx7 14 0.68 6.26 1.3
80 INT85765 Localization of PEBP1 3 0.73 0.83 1.3
81 INT13705 Regulation of Pebp1 2 0.26 0.85 1.3
82 INT141862 Binding of Cav1 11 0.36 1.32 1.25
83 INT131645 Negative_regulation of Nf1 10 0.58 8.12 1.24
84 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23
85 INT9323 Transcription of Igf1r 2 0.63 1.08 1.23
86 INT168095 Positive_regulation of Transcription of Cav3 1 0.47 0.91 1.2
87 INT102073 Regulation of Gene_expression of APC 5 0.45 6.09 1.15
88 INT314388 Positive_regulation of Gene_expression of Ptpn6 3 0.11 0.05 1.15
89 INT321016 Regulation of Positive_regulation of Ptpn6 1 0.05 0.05 1.15
90 INT139764 Negative_regulation of CAV1 10 0.58 6.57 1.14
91 INT189771 Gene_expression of DAG1 5 0.27 4.14 1.12
92 INT321020 Regulation of Protein_catabolism of Ptpn6 1 0.06 0.05 1.12
93 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1
94 INT147416 Positive_regulation of Transcription of Igf1r 1 0.46 0.72 1.1
95 INT147415 Positive_regulation of Igf1r 2 0.43 0.97 1.09
96 INT211095 Negative_regulation of Dag1 14 0.57 7.18 1.07
97 INT168957 Positive_regulation of CAV3 1 0.40 0 1.06
98 INT168960 Binding of CAV3 1 0.30 0 1.05
99 INT216661 Regulation of Positive_regulation of P2rx7 1 0.07 0 1
100 INT191121 Regulation of Gene_expression of P2RX7 3 0.36 3.69 0.99
101 INT136613 Negative_regulation of Cav1 2 0.57 2.28 0.96
102 INT113887 Positive_regulation of Negative_regulation of P2rx7 1 0.22 1.02 0.96
103 INT149903 Localization of Cav3 3 0.80 1.1 0.93
104 INT215567 Positive_regulation of Positive_regulation of P2RX7 2 0.45 0.07 0.93
105 INT153670 Positive_regulation of Gene_expression of CAV1 26 0.69 44.27 0.92
106 INT242134 Localization of Apc 8 0.74 4.83 0.88
107 INT64044 Localization of DAG1 3 0.59 0.27 0.87
108 INT141442 Negative_regulation of Phosphorylation of Cav1 1 0.59 0.94 0.87
109 INT151776 Positive_regulation of Transcription of P2rx7 1 0.03 0.53 0.86
110 INT225221 Negative_regulation of Nf2 1 0.57 18.06 0.83
111 INT149905 Negative_regulation of Cav3 2 0.43 0.98 0.82
112 INT102262 Localization of NF2 1 0.14 0.6 0.79
113 INT112090 Negative_regulation of Gene_expression of Cav1 8 0.57 3.5 0.78
114 INT271589 Regulation of Transcription of P2rx7 1 0.05 0.5 0.78
115 INT130057 Positive_regulation of CAV1 12 0.65 8.96 0.77
116 INT278119 Positive_regulation of Localization of P2RX7 2 0.45 1.14 0.77
117 INT112088 Regulation of Cav1 2 0.44 0.51 0.73
118 INT57062 Regulation of APC 24 0.58 14.3 0.7
119 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69
120 INT153667 Localization of CAV1 15 0.76 11.92 0.68
121 INT68179 Gene_expression of Nf1 9 0.78 8.87 0.68
122 INT179133 Localization of Nf1 2 0.80 2.18 0.68
123 INT49650 Gene_expression of Nf1 4 0.76 3.38 0.67
124 INT125734 Negative_regulation of Transcription of P2rx7 1 0.38 0.81 0.67
125 INT283119 Regulation of Dag1 4 0.44 1.98 0.65
126 INT202848 Gene_expression of Nf2 5 0.59 4.93 0.63
127 INT321017 Negative_regulation of Protein_catabolism of Ptpn6 1 0.08 0.19 0.63
128 INT6168 Negative_regulation of Regulation of Ptpn6 1 0.15 0 0.62
129 INT168963 Negative_regulation of Binding of CAV3 1 0.30 0 0.62
130 INT168962 Positive_regulation of Localization of CAV3 1 0.40 0 0.62
131 INT60057 Negative_regulation of Localization of Ptpn6 1 0.31 0.39 0.62
132 INT185485 Negative_regulation of Localization of P2rx7 1 0.26 0.95 0.62
133 INT168953 Localization of CAV3 1 0.60 0 0.62
134 INT86700 Regulation of Cav1 7 0.54 0.92 0.61
135 INT283110 Localization of Dag1 5 0.73 3.14 0.61
136 INT131001 Regulation of CAV1 6 0.44 3.77 0.59
137 INT141863 Negative_regulation of Gene_expression of Cav1 4 0.49 1.77 0.58
138 INT168955 Phosphorylation of CAV3 1 0.56 0 0.58
139 INT106022 Negative_regulation of GSTP1 5 0.59 2.12 0.55
140 INT145859 Regulation of Gene_expression of Igf1r 1 0.59 1.58 0.55
141 INT72869 Regulation of Negative_regulation of APC 2 0.36 1.7 0.54
142 INT120762 Regulation of GSTP1 2 0.45 3.66 0.54
143 INT61992 Positive_regulation of Gene_expression of NF1 3 0.50 4.47 0.51
144 INT153099 Negative_regulation of Positive_regulation of P2rx7 1 0.42 0.25 0.5
145 INT215732 Negative_regulation of Binding of P2rx7 1 0.11 0.74 0.49
146 INT86702 Localization of Cav1 8 0.69 0.76 0.47
147 INT316933 Transcription of Nf1 1 0.18 0.49 0.47
148 INT316939 Positive_regulation of Transcription of Nf1 1 0.16 0.49 0.47
149 INT151720 Negative_regulation of Positive_regulation of Apc 3 0.37 2.15 0.46
150 INT153672 Negative_regulation of Negative_regulation of CAV1 1 0.25 0.2 0.46
151 INT151482 Negative_regulation of Binding of Ptpn6 1 0.00 0 0.46
152 INT278114 Negative_regulation of Negative_regulation of P2rx7 1 0.21 0 0.45
153 INT15900 Gene_expression of PEBP1 5 0.61 2.57 0.44
154 INT230265 Binding of Cav3 2 0.42 0.74 0.44
155 INT220504 Positive_regulation of Gene_expression of Cav1 11 0.39 6.26 0.43
156 INT166240 Regulation of Gene_expression of Cav1 3 0.51 1.03 0.43
157 INT215741 Positive_regulation of Transcription of P2rx7 1 0.15 1.15 0.43
158 INT321009 Regulation of Gene_expression of Ptpn6 1 0.05 0.3 0.43
159 INT152151 Regulation of Gene_expression of Apc 4 0.44 3.87 0.42
160 INT161281 Negative_regulation of Positive_regulation of Pebp1 1 0.07 0 0.41
161 INT168952 Positive_regulation of Gene_expression of CAV3 1 0.49 0 0.4
162 INT18646 Transcription of Pebp1 1 0.50 0.39 0.4
163 INT217017 Transcription of P2RX7 1 0.27 0.36 0.39
164 INT220506 Binding of Cav1 13 0.45 5.46 0.38
165 INT283120 Regulation of Gene_expression of Dag1 4 0.52 1.32 0.38
166 INT168940 Phosphorylation of Igf1r 1 0.77 2.18 0.38
167 INT135953 Negative_regulation of Positive_regulation of Cav1 2 0.37 1.09 0.37
168 INT284325 Positive_regulation of Gene_expression of DAG1 3 0.13 1.08 0.36
169 INT163277 Negative_regulation of Gene_expression of CAV1 17 0.56 10.77 0.35
170 INT87406 Gene_expression of GSTP1 16 0.77 11.37 0.35
171 INT220170 Regulation of Positive_regulation of Apc 1 0.10 0.46 0.35
172 INT149904 Regulation of Gene_expression of Cav3 1 0.27 0.35 0.35
173 INT149906 Regulation of Localization of Cav3 1 0.61 0.41 0.35
174 INT112334 Regulation of NF1 18 0.52 15.85 0.34
175 INT118243 Transcription of APC 4 0.45 3.33 0.33
176 INT184605 Positive_regulation of Transcription of APC 2 0.19 2.39 0.33
177 INT225667 Transcription of Apc 3 0.52 3.73 0.32
178 INT121239 Regulation of Positive_regulation of P2rx7 2 0.61 1.32 0.32
179 INT210766 Gene_expression of Igf1r 6 0.65 2.15 0.31
180 INT195672 Localization of APC 7 0.74 3.76 0.3
181 INT141867 Positive_regulation of Transcription of Cav1 2 0.52 0.46 0.29
182 INT141868 Transcription of Cav1 2 0.54 1.48 0.29
183 INT141861 Negative_regulation of Binding of Cav1 1 0.44 0.4 0.29
184 INT216937 Regulation of Binding of P2rx7 1 0.44 0.08 0.29
185 INT225219 Positive_regulation of Gene_expression of Nf2 1 0.43 1.27 0.27
186 INT146278 Negative_regulation of Gene_expression of P2RX7 2 0.42 0.21 0.25
187 INT278169 Regulation of Regulation of GSTP1 1 0.45 1.1 0.25
188 INT322030 Regulation of Positive_regulation of P2RX7 1 0.41 0.55 0.24
189 INT216938 Negative_regulation of Localization of P2rx7 1 0.37 0.25 0.24
190 INT129342 Positive_regulation of Positive_regulation of Nf1 1 0.50 0.79 0.23
191 INT135956 Phosphorylation of Cav1 5 0.64 2.24 0.22
192 INT68180 Regulation of Nf1 2 0.27 2.02 0.22
193 INT286203 Protein_catabolism of Dag1 2 0.26 1.56 0.22
194 INT135954 Positive_regulation of Phosphorylation of Cav1 2 0.40 0.64 0.22
195 INT225666 Regulation of Transcription of Apc 1 0.29 0.33 0.22
196 INT141860 Regulation of Localization of Cav1 1 0.20 0.2 0.22
197 INT250517 Phosphorylation of Igf1r 5 0.79 1.21 0.21
198 INT316917 Negative_regulation of Protein_catabolism of Dag1 1 0.12 0.44 0.21
199 INT283102 Positive_regulation of Dag1 1 0.49 1.31 0.21
200 INT177938 Negative_regulation of NF1 9 0.43 10.3 0.2
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